Sodium channel protein type 5 subunit alpha

A sodium channel protein type 5 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14524]

Synonyms

Sodium channel protein cardiac muscle subunit alpha;
Sodium channel protein type V subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.5;
hH1

Research

Bioassay Publications (31)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (3.23)	18.2507
2000's	5 (16.13)	29.6817
2010's	21 (67.74)	24.3611
2020's	4 (12.90)	2.80

Compounds (87)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phenytoin	Homo sapiens (human)	IC50	74.5000	2	2
5-(n,n-hexamethylene)amiloride	Homo sapiens (human)	IC50	30.0000	1	1
alfuzosin	Homo sapiens (human)	IC50	892.2080	2	2
amiodarone	Homo sapiens (human)	IC50	4.8000	1	1
amitriptyline	Homo sapiens (human)	IC50	10.8000	2	2
bepridil	Homo sapiens (human)	IC50	3.7000	1	1
verapamil	Homo sapiens (human)	IC50	41.5000	1	1
chlorpromazine	Homo sapiens (human)	IC50	4.3000	1	1
cifenline	Homo sapiens (human)	IC50	7.8000	1	1
cisapride	Homo sapiens (human)	IC50	14.7000	1	1
desipramine	Homo sapiens (human)	IC50	1.5200	1	1
diphenhydramine	Homo sapiens (human)	IC50	41.0000	1	1
flecainide	Homo sapiens (human)	IC50	6.5000	1	1
haloperidol	Homo sapiens (human)	IC50	7.0000	1	1
lidocaine	Homo sapiens (human)	IC50	108.0000	1	1
imipramine	Homo sapiens (human)	IC50	3.6000	1	1
lamotrigine	Homo sapiens (human)	IC50	67.2702	3	3
loperamide	Homo sapiens (human)	IC50	0.2390	1	1
mexiletine	Homo sapiens (human)	IC50	107.4000	5	5
nifedipine	Homo sapiens (human)	IC50	37.0000	1	1
nitrendipine	Homo sapiens (human)	IC50	36.0000	1	1
propafenone	Homo sapiens (human)	IC50	3.1633	3	3
propranolol	Homo sapiens (human)	IC50	2.1000	1	1
quetiapine	Homo sapiens (human)	IC50	16.9000	1	1
risperidone	Homo sapiens (human)	IC50	102.0000	1	1
terfenadine	Homo sapiens (human)	IC50	0.9710	1	1
tetracaine	Homo sapiens (human)	IC50	0.5075	4	4
thioridazine	Homo sapiens (human)	IC50	1.8300	1	1
prenylamine	Homo sapiens (human)	IC50	2.5200	1	1
amiloride	Homo sapiens (human)	IC50	30.0000	1	1
pimozide	Homo sapiens (human)	IC50	0.0540	1	1
mexiletine hydrochloride	Homo sapiens (human)	IC50	7.8000	1	1
diltiazem	Homo sapiens (human)	IC50	9.0000	1	1
lidamidine	Homo sapiens (human)	IC50	30.0000	1	1
ranolazine	Homo sapiens (human)	IC50	147.2333	3	1
sertindole	Homo sapiens (human)	IC50	2.3000	1	1
mibefradil	Homo sapiens (human)	IC50	0.7400	2	2
duloxetine	Homo sapiens (human)	IC50	11.8961	2	2
nelfinavir	Homo sapiens (human)	IC50	290.3099	2	2
tedisamil	Homo sapiens (human)	IC50	20.0000	1	1
nebivolol	Homo sapiens (human)	IC50	7.1264	2	2
uk 68798	Homo sapiens (human)	IC50	386.7962	4	4
doripenem	Homo sapiens (human)	IC50	1,584.8900	1	1
tadalafil	Homo sapiens (human)	IC50	142.1910	2	2
paliperidone	Homo sapiens (human)	IC50	91.8040	2	2
desvenlafaxine	Homo sapiens (human)	IC50	257.8770	2	2
moxifloxacin	Homo sapiens (human)	IC50	145.4998	2	2
solifenacin	Homo sapiens (human)	IC50	6.3096	1	1
telbivudine	Homo sapiens (human)	IC50	3,162.2800	1	1
etravirine	Homo sapiens (human)	IC50	2,241.1285	2	2
lapatinib	Homo sapiens (human)	IC50	3,162.2800	1	1
darunavir	Homo sapiens (human)	IC50	69.9054	2	2
deferasirox	Homo sapiens (human)	IC50	290.3099	2	2
lacosamide	Homo sapiens (human)	IC50	501.1870	1	1
quinidine	Homo sapiens (human)	IC50	11.7500	2	2
tolterodine	Homo sapiens (human)	IC50	18.9662	2	2
darifenacin	Homo sapiens (human)	IC50	1.5849	1	1
s 1033	Homo sapiens (human)	IC50	3,005.9350	2	2
ica-121431	Homo sapiens (human)	IC50	9.6000	2	2
maraviroc	Homo sapiens (human)	IC50	815.4785	2	2
3-hydroxymexiletine	Homo sapiens (human)	IC50	102.0000	2	2
dasatinib	Homo sapiens (human)	IC50	249.0535	2	2
sitagliptin	Homo sapiens (human)	IC50	712.6425	2	2
silodosin	Homo sapiens (human)	IC50	63.0957	1	1
fluvoxamine	Homo sapiens (human)	IC50	39.4000	1	1
su 11248	Homo sapiens (human)	IC50	27.8298	2	2
alvimopan anhydrous	Homo sapiens (human)	IC50	251.1890	1	1
palonosetron	Homo sapiens (human)	IC50	19.9526	1	1
everolimus	Homo sapiens (human)	IC50	415.2415	2	2
lu 208075	Homo sapiens (human)	IC50	1,129.4650	2	2
n-demethylloperamide	Homo sapiens (human)	IC50	0.4830	1	1
tetrodotoxin	Homo sapiens (human)	IC50	0.5150	2	2
a 803467	Homo sapiens (human)	IC50	12.4000	4	4
cnv1014802	Homo sapiens (human)	IC50	84.0000	1	1
zetekitoxin ab	Homo sapiens (human)	IC50	0.0003	1	1
mk-3102	Homo sapiens (human)	IC50	30.0000	1	1
n-dodecyl-l-lysine amide	Homo sapiens (human)	IC50	33.1131	1	1
raltegravir	Homo sapiens (human)	IC50	950.5590	2	2
mk-8825	Homo sapiens (human)	IC50	20.0000	1	1
saxitoxin	Homo sapiens (human)	IC50	0.2100	1	1
gs-458967	Homo sapiens (human)	IC50	2.7832	5	5
trv130	Homo sapiens (human)	IC50	10.6000	2	2
ajmaline	Homo sapiens (human)	IC50	8.2000	1	1
sildenafil	Homo sapiens (human)	IC50	880.0585	2	2
vardenafil	Homo sapiens (human)	IC50	1,355.7080	2	2
amg531	Homo sapiens (human)	IC50	237.3585	2	2
thiamet g	Homo sapiens (human)	IC50	30.0000	1	1

Enables

This protein enables 17 target(s):

Target	Category	Definition
voltage-gated sodium channel activity	molecular function	Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
fibroblast growth factor binding	molecular function	Binding to a fibroblast growth factor. [PMID:9806903]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
protein domain specific binding	molecular function	Binding to a specific domain of a protein. [GOC:go_curators]
ankyrin binding	molecular function	Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
transmembrane transporter binding	molecular function	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
nitric-oxide synthase binding	molecular function	Binding to nitric-oxide synthase. [GOC:ai]
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	molecular function	Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
voltage-gated sodium channel activity involved in AV node cell action potential	molecular function	Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
voltage-gated sodium channel activity involved in bundle of His cell action potential	molecular function	Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
voltage-gated sodium channel activity involved in Purkinje myocyte action potential	molecular function	Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
voltage-gated sodium channel activity involved in SA node cell action potential	molecular function	Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
scaffold protein binding	molecular function	Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]

Located In

This protein is located in 13 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nucleolus	cellular component	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
caveola	cellular component	A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
intercalated disc	cellular component	A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. [GOC:mtg_muscle, PMID:11732910]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
lateral plasma membrane	cellular component	The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr]
Z disc	cellular component	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194]
T-tubule	cellular component	Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194]
sarcolemma	cellular component	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated sodium channel complex	cellular component	A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732]

Involved In

This protein is involved in 37 target(s):

Target	Category	Definition
regulation of heart rate	biological process	Any process that modulates the frequency or rate of heart contraction. [GOC:dph, GOC:tb, PMID:10358008]
cardiac conduction system development	biological process	The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. [GOC:mtg_heart]
cardiac ventricle development	biological process	The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]
brainstem development	biological process	The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. [GOC:dph]
sodium ion transport	biological process	The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
positive regulation of sodium ion transport	biological process	Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]
response to denervation involved in regulation of muscle adaptation	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation. [GOC:mtg_muscle]
telencephalon development	biological process	The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
cerebellum development	biological process	The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
sodium ion transmembrane transport	biological process	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
odontogenesis of dentin-containing tooth	biological process	The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]
positive regulation of action potential	biological process	Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:go_curators]
positive regulation of epithelial cell proliferation	biological process	Any process that activates or increases the rate or extent of epithelial cell proliferation. [GOC:ai]
membrane depolarization	biological process	The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dh, Wikipedia:Depolarization]
cardiac muscle contraction	biological process	Muscle contraction of cardiac muscle tissue. [GOC:dph]
regulation of ventricular cardiac muscle cell membrane repolarization	biological process	Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
regulation of atrial cardiac muscle cell membrane depolarization	biological process	Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb]
regulation of atrial cardiac muscle cell membrane repolarization	biological process	Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb]
regulation of ventricular cardiac muscle cell membrane depolarization	biological process	Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte. [GOC:dph, GOC:tb]
cellular response to calcium ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:mah]
cardiac muscle cell action potential involved in contraction	biological process	An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
regulation of cardiac muscle cell contraction	biological process	Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
ventricular cardiac muscle cell action potential	biological process	An action potential that occurs in a ventricular cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during action potential	biological process	The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during cardiac muscle cell action potential	biological process	The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
atrial cardiac muscle cell action potential	biological process	An action potential that occurs in an atrial cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
SA node cell action potential	biological process	An action potential that occurs in a sinoatrial node cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
AV node cell action potential	biological process	An action potential that occurs in an atrioventricular node cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
bundle of His cell action potential	biological process	An action potential that occurs in a bundle of His cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during AV node cell action potential	biological process	The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during SA node cell action potential	biological process	The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during Purkinje myocyte cell action potential	biological process	The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during bundle of His cell action potential	biological process	The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
AV node cell to bundle of His cell communication	biological process	The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
regulation of heart rate by cardiac conduction	biological process	A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during atrial cardiac muscle cell action potential	biological process	The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
regulation of sodium ion transmembrane transport	biological process	Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]