Proteins > Neuronal acetylcholine receptor subunit alpha-7
Page last updated: 2024-08-07 16:35:30
Neuronal acetylcholine receptor subunit alpha-7
A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36544]
Synonyms
Research
Bioassay Publications (68)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (7.35) | 18.2507 |
| 2000's | 19 (27.94) | 29.6817 |
| 2010's | 37 (54.41) | 24.3611 |
| 2020's | 7 (10.29) | 2.80 |
Compounds (60)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.Journal of natural products, , 04-27, Volume: 81, Issue:4, 2018
Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain.Bioorganic & medicinal chemistry, , Oct-01, Volume: 20, Issue:19, 2012
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.Journal of agricultural and food chemistry, , Volume: 48, Issue:12, 2000
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 15, Issue:22, 2005
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
[no title available]Journal of medicinal chemistry, , 02-28, Volume: 62, Issue:4, 2019
Neonicotinic analogues: selective antagonists for α4β2 nicotinic acetylcholine receptors.Bioorganic & medicinal chemistry, , May-15, Volume: 21, Issue:10, 2013
Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 23, Issue:13, 2013
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.Journal of medicinal chemistry, , Nov-08, Volume: 55, Issue:21, 2012
Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.Bioorganic & medicinal chemistry, , Oct-15, Volume: 19, Issue:20, 2011
Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.Journal of medicinal chemistry, , Oct-14, Volume: 53, Issue:19, 2010
A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.Journal of medicinal chemistry, , Jul-23, Volume: 52, Issue:14, 2009
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.Journal of medicinal chemistry, , Sep-20, Volume: 50, Issue:19, 2007
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 15, Issue:22, 2005
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.Bioorganic & medicinal chemistry letters, , Feb-12, Volume: 11, Issue:3, 2001
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.Journal of agricultural and food chemistry, , Volume: 48, Issue:12, 2000
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.Journal of medicinal chemistry, , Jan-31, Volume: 40, Issue:3, 1997
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.Journal of medicinal chemistry, , Jan-31, Volume: 40, Issue:3, 1997
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.Journal of medicinal chemistry, , Jan-31, Volume: 40, Issue:3, 1997
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
[no title available]Journal of medicinal chemistry, , 08-26, Volume: 64, Issue:16, 2021
Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: a new target for a privileged structure.European journal of medicinal chemistry, , Oct-30, Volume: 86, 2014
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Discovery and development of α7 nicotinic acetylcholine receptor modulators.Journal of medicinal chemistry, , Dec-08, Volume: 54, Issue:23, 2011
Designed multiple ligands. An emerging drug discovery paradigm.Journal of medicinal chemistry, , Oct-20, Volume: 48, Issue:21, 2005
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.Bioorganic & medicinal chemistry letters, , Feb-12, Volume: 11, Issue:3, 2001
Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.Journal of medicinal chemistry, , May-22, Volume: 57, Issue:10, 2014
Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.Journal of medicinal chemistry, , Jun-17, Volume: 42, Issue:12, 1999
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Feb-12, Volume: 41, Issue:4, 1998
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Discovery and development of α7 nicotinic acetylcholine receptor modulators.Journal of medicinal chemistry, , Dec-08, Volume: 54, Issue:23, 2011
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding.Journal of medicinal chemistry, , Oct-23, Volume: 51, Issue:20, 2008
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.European journal of medicinal chemistry, , Dec-05, Volume: 160, 2018
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding.Journal of medicinal chemistry, , Oct-23, Volume: 51, Issue:20, 2008
From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue.Journal of medicinal chemistry, , 07-28, Volume: 65, Issue:14, 2022
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.Journal of medicinal chemistry, , 12-13, Volume: 61, Issue:23, 2018
Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Discovery and development of α7 nicotinic acetylcholine receptor modulators.Journal of medicinal chemistry, , Dec-08, Volume: 54, Issue:23, 2011
Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.Journal of medicinal chemistry, , Oct-14, Volume: 53, Issue:19, 2010
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors.Bioorganic & medicinal chemistry, , May-01, Volume: 21, Issue:9, 2013
Discovery and development of α7 nicotinic acetylcholine receptor modulators.Journal of medicinal chemistry, , Dec-08, Volume: 54, Issue:23, 2011
Exploring α7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB.ACS medicinal chemistry letters, , Nov-11, Volume: 1, Issue:8, 2010
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021
[no title available]Journal of medicinal chemistry, , 02-13, Volume: 63, Issue:3, 2020
Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: a new target for a privileged structure.European journal of medicinal chemistry, , Oct-30, Volume: 86, 2014
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.Journal of medicinal chemistry, , May-28, Volume: 52, Issue:10, 2009
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.Journal of medicinal chemistry, , Jul-23, Volume: 52, Issue:14, 2009
Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.European journal of medicinal chemistry, , Dec-05, Volume: 160, 2018
Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists.European journal of medicinal chemistry, , Jun-10, Volume: 115, 2016
Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Discovery and development of α7 nicotinic acetylcholine receptor modulators.Journal of medicinal chemistry, , Dec-08, Volume: 54, Issue:23, 2011
Enables
This protein enables 10 target(s):
| Target | Category | Definition |
|---|
| amyloid-beta binding | molecular function | Binding to an amyloid-beta peptide/protein. [GOC:hjd] |
| monoatomic ion channel activity | molecular function | Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] |
| calcium channel activity | molecular function | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| acetylcholine receptor activity | molecular function | Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling] |
| toxic substance binding | molecular function | Binding to a toxic substance, a poisonous substance that causes damage to biological systems. [GOC:bf, GOC:curators, GOC:jl, GOC:pr] |
| chloride channel regulator activity | molecular function | Binds to and modulates the activity of a chloride channel. [GOC:mah] |
| acetylcholine-gated monoatomic cation-selective channel activity | molecular function | Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. [GOC:mah, PMID:2466967] |
| acetylcholine binding | molecular function | Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| plasma membrane raft | cellular component | A membrane raft that is part of the plasma membrane. [GOC:jl] |
| postsynaptic membrane | cellular component | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732] |
| postsynapse | cellular component | The part of a synapse that is part of the post-synaptic cell. [GOC:dos] |
Active In
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| neuron projection | cellular component | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| acetylcholine-gated channel complex | cellular component | A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462] |
Involved In
This protein is involved in 38 target(s):
| Target | Category | Definition |
|---|
| response to hypoxia | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd] |
| positive regulation of protein phosphorylation | biological process | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd] |
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| calcium ion transport | biological process | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| intracellular calcium ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah] |
| signal transduction | biological process | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] |
| synaptic transmission, cholinergic | biological process | The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, Wikipedia:Cholinergic] |
| learning or memory | biological process | The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125] |
| memory | biological process | The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). [GOC:curators, ISBN:0582227089] |
| short-term memory | biological process | The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] |
| positive regulation of cell population proliferation | biological process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
| negative regulation of tumor necrosis factor production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120] |
| monoatomic ion transmembrane transport | biological process | A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah] |
| response to nicotine | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089] |
| positive regulation of MAPK cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators] |
| positive regulation of angiogenesis | biological process | Any process that activates or increases angiogenesis. [GOC:go_curators] |
| synapse organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai, GOC:pr] |
| cognition | biological process | The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. [ISBN:0721619908] |
| sensory processing | biological process | Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect. [GOC:dph, ISBN:0721662544] |
| positive regulation of protein metabolic process | biological process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai] |
| excitatory postsynaptic potential | biological process | A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef] |
| positive regulation of ERK1 and ERK2 cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |
| acetylcholine receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. [GOC:mah] |
| dendritic spine organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. [GOC:BHF, PMID:20410104] |
| modulation of excitatory postsynaptic potential | biological process | Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dos] |
| dendrite arborization | biological process | The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches. [GOC:aruk, GOC:bc, PMID:23270857] |
| positive regulation of long-term synaptic potentiation | biological process | Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie] |
| positive regulation of amyloid-beta formation | biological process | Any process that activates or increases the frequency, rate or extent of amyloid-beta formation. [GOC:dph, GOC:TermGenie, PMID:17098871] |
| negative regulation of amyloid-beta formation | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation. [GOC:hjd, GOC:TermGenie, PMID:22992957] |
| regulation of amyloid precursor protein catabolic process | biological process | Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793] |
| response to amyloid-beta | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824] |
| response to acetylcholine | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497] |
| regulation of amyloid fibril formation | biological process | Any process that modulates the frequency, rate or extent of amyloid fibril formation. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396] |
| positive regulation of CoA-transferase activity | biological process | Any process that activates or increases the frequency, rate or extent of CoA-transferase activity. [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] |
| positive regulation of excitatory postsynaptic potential | biological process | Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:bf, GOC:BHF] |
| regulation of membrane potential | biological process | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |