Proteins > Tyrosine-protein phosphatase non-receptor type 1
Page last updated: 2024-08-07 16:04:24
Tyrosine-protein phosphatase non-receptor type 1
A tyrosine-protein phosphatase non-receptor type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18031]
Synonyms
EC 3.1.3.48;
Protein-tyrosine phosphatase 1B;
PTP-1B
Research
Bioassay Publications (162)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (1.23) | 18.2507 |
| 2000's | 50 (30.86) | 29.6817 |
| 2010's | 94 (58.02) | 24.3611 |
| 2020's | 16 (9.88) | 2.80 |
Compounds (200)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| salicylic acid | Homo sapiens (human) | Ki | 19,400.0000 | 1 | 1 |
| 4-hydroxyphenylglyoxylic acid | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| palmitic acid | Homo sapiens (human) | IC50 | 8.8000 | 1 | 1 |
| 5-iodo-2-(oxaloamino)benzoic acid | Homo sapiens (human) | Ki | 23,816,533,342.7085 | 3 | 3 |
| benzbromarone | Homo sapiens (human) | IC50 | 53.8000 | 2 | 0 |
| berberine | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |
| chromone-2-carboxylic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| fluorescite | Homo sapiens (human) | IC50 | 600.0000 | 1 | 1 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| pioglitazone | Homo sapiens (human) | IC50 | 220.0000 | 1 | 1 |
| stearic acid | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| suramin | Homo sapiens (human) | IC50 | 9.7600 | 1 | 1 |
| troglitazone | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| cantharidin | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| bromoacetate | Homo sapiens (human) | Ki | 77,000.0000 | 1 | 1 |
| phenacyl bromide | Homo sapiens (human) | Ki | 81.0000 | 1 | 1 |
| trypan blue | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| peracetic acid | Homo sapiens (human) | Ki | 17,000.0000 | 1 | 1 |
| 9,10-phenanthrenequinone | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| 1-hydroxy-2-naphthoic acid | Homo sapiens (human) | IC50 | 850.0000 | 1 | 1 |
| 4-phenylphenol | Homo sapiens (human) | IC50 | 162,181.0000 | 1 | 1 |
| 3-hydroxy-2-naphthoic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| sulfosalicylic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 3-hydroxybenzoic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alpha-resorcylic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| pamoic acid | Homo sapiens (human) | IC50 | 310.0000 | 1 | 1 |
| 3-phenylsalicylic acid | Homo sapiens (human) | IC50 | 859.0000 | 1 | 1 |
| evans blue | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| lithocholic acid | Homo sapiens (human) | IC50 | 7.7250 | 2 | 2 |
| glycyrrhetinic acid | Homo sapiens (human) | IC50 | 32.9000 | 2 | 2 |
| oxanilic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| arachidic acid | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| oleanolic acid | Homo sapiens (human) | IC50 | 54.4403 | 46 | 47 |
| oleanolic acid | Homo sapiens (human) | Ki | 6.0000 | 2 | 2 |
| 1,2-naphthoquinone | Homo sapiens (human) | IC50 | 1.6400 | 1 | 1 |
| phthalonic acid | Homo sapiens (human) | IC50 | 1,500.0000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2-naphthylacetic acid | Homo sapiens (human) | IC50 | 3,500.0000 | 1 | 1 |
| mandelic acid, (r)-isomer | Homo sapiens (human) | IC50 | 5,500.0000 | 1 | 1 |
| phenylglyoxylic acid | Homo sapiens (human) | IC50 | 2,700.0000 | 1 | 1 |
| carmine | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| glycyrrhizic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| palmatine | Homo sapiens (human) | IC50 | 234.0000 | 1 | 1 |
| alpha-tocopherol succinate | Homo sapiens (human) | IC50 | 32.4175 | 4 | 4 |
| allura red ac dye | Homo sapiens (human) | IC50 | 33.0000 | 1 | 1 |
| vanadates | Homo sapiens (human) | IC50 | 16.9288 | 2 | 4 |
| ursolic acid | Homo sapiens (human) | IC50 | 6.6839 | 38 | 38 |
| ursolic acid | Homo sapiens (human) | Ki | 4.9000 | 2 | 2 |
| betulinic acid | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| 2-bromo-4'-nitroacetophenone | Homo sapiens (human) | Ki | 195.0000 | 1 | 1 |
| 5,5'-methylenedisalicylic acid | Homo sapiens (human) | IC50 | 3,600.0000 | 1 | 1 |
| 5-fluorosalicylic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| atranorin | Homo sapiens (human) | IC50 | 63.5000 | 1 | 1 |
| avarol | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| kaurenoic acid | Homo sapiens (human) | IC50 | 20.2000 | 1 | 1 |
| beta-amyrin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| lobaric acid | Homo sapiens (human) | IC50 | 0.8350 | 2 | 2 |
| alpha-amyrin | Homo sapiens (human) | IC50 | 19.2600 | 1 | 1 |
| sigmoidin a | Homo sapiens (human) | IC50 | 14.4000 | 1 | 1 |
| madecassic acid | Homo sapiens (human) | IC50 | 12.3800 | 1 | 1 |
| maslinic acid | Homo sapiens (human) | IC50 | 5.9300 | 1 | 1 |
| methyl orsellinate | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| rosiglitazone | Homo sapiens (human) | IC50 | 215.0000 | 2 | 2 |
| benzylphosphonic acid | Homo sapiens (human) | Ki | 3,000.0000 | 1 | 1 |
| 3-bromo-4,5-dihydroxybenzaldehyde | Homo sapiens (human) | IC50 | 354.2000 | 1 | 1 |
| prunin protein, prunus | Homo sapiens (human) | IC50 | 17.5000 | 1 | 1 |
| uvaol | Homo sapiens (human) | IC50 | 15.6000 | 1 | 1 |
| osajin | Homo sapiens (human) | IC50 | 23.6000 | 1 | 1 |
| osajin | Homo sapiens (human) | Ki | 29.9000 | 1 | 1 |
| 6,7-dichloroquinoline-5,8-dione | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| erythrodiol | Homo sapiens (human) | IC50 | 14.8000 | 2 | 2 |
| geniposide | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| 4-methoxymandelic acid | Homo sapiens (human) | IC50 | 5,700.0000 | 1 | 1 |
| liquiritigenin | Homo sapiens (human) | IC50 | 70.0000 | 3 | 3 |
| asiatic acid | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| phaseollidin | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| celastrol | Homo sapiens (human) | IC50 | 6.7000 | 3 | 3 |
| glabridin | Homo sapiens (human) | IC50 | 73.4000 | 1 | 1 |
| oleanolic acid 3-acetate | Homo sapiens (human) | IC50 | 21.5000 | 1 | 1 |
| moracin c | Homo sapiens (human) | IC50 | 10.2000 | 1 | 1 |
| ertiprotafib | Homo sapiens (human) | IC50 | 1.1798 | 11 | 11 |
| ertiprotafib | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| cryptotanshinone | Homo sapiens (human) | IC50 | 33.5000 | 1 | 1 |
| boswellic acid | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Chromone-3-carboxylic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| cyperin | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| procurcumenol | Homo sapiens (human) | IC50 | 45.6000 | 1 | 1 |
| pinocembrin | Homo sapiens (human) | IC50 | 36.7300 | 1 | 1 |
| benzarone | Homo sapiens (human) | IC50 | 150.0000 | 2 | 0 |
| 5-methoxycanthin-6-one | Homo sapiens (human) | IC50 | 20.3000 | 1 | 1 |
| 5-methoxycanthin-6-one | Homo sapiens (human) | Ki | 10.3300 | 1 | 1 |
| nsc-89199 | Homo sapiens (human) | IC50 | 62.4000 | 1 | 1 |
| lupeol | Homo sapiens (human) | IC50 | 2.1200 | 2 | 2 |
| o-iodoxybenzoic acid | Homo sapiens (human) | IC50 | 1,160.0000 | 1 | 1 |
| nsc 663284 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| nsc668394 | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
| pomolic acid | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| naringenin | Homo sapiens (human) | IC50 | 130.1000 | 1 | 1 |
| mandelic acid, (s)-isomer | Homo sapiens (human) | IC50 | 4,900.0000 | 1 | 1 |
| Tautomycin | Homo sapiens (human) | IC50 | 0.0007 | 1 | 1 |
| abyssinone v | Homo sapiens (human) | IC50 | 31.1500 | 2 | 2 |
| genipin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| naringin | Homo sapiens (human) | IC50 | 75.9000 | 2 | 2 |
| isonaringin | Homo sapiens (human) | IC50 | 56.5000 | 1 | 1 |
| syringaresinol | Homo sapiens (human) | IC50 | 15.0100 | 1 | 1 |
| yangambin | Homo sapiens (human) | IC50 | 16.8200 | 1 | 1 |
| 2-(oxaloamino)benzoic acid | Homo sapiens (human) | Ki | 14,483,666,681.9696 | 3 | 3 |
| resveratrol | Homo sapiens (human) | IC50 | 525.0000 | 2 | 2 |
| cyanoginosin lr | Homo sapiens (human) | IC50 | 0.0012 | 1 | 1 |
| palmitoleic acid | Homo sapiens (human) | IC50 | 6.4000 | 1 | 1 |
| oleic acid | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
| okadaic acid | Homo sapiens (human) | IC50 | 0.4537 | 3 | 3 |
| (+)-usnic acid | Homo sapiens (human) | IC50 | 16.4000 | 1 | 1 |
| shikonin | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| gancaonin I | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| 6,8-diprenylgenistein | Homo sapiens (human) | IC50 | 5.8000 | 2 | 2 |
| 6,8-diprenylgenistein | Homo sapiens (human) | Ki | 9.6000 | 1 | 1 |
| licoricidin | Homo sapiens (human) | IC50 | 5.9000 | 1 | 1 |
| Euchrestaflavanone A | Homo sapiens (human) | IC50 | 32.2500 | 2 | 2 |
| moronic acid | Homo sapiens (human) | IC50 | 13.2000 | 2 | 2 |
| moronic acid | Homo sapiens (human) | Ki | 8.0000 | 1 | 1 |
| morolic acid | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| morolic acid | Homo sapiens (human) | Ki | 7.1000 | 1 | 1 |
| 4-phenyl-4-oxo-2-hydroxybuten-2-oic acid | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| licocoumarone | Homo sapiens (human) | IC50 | 71.2000 | 1 | 1 |
| Methyl Haematommate | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | IC50 | 137.7400 | 1 | 1 |
| trans-4-coumaric acid | Homo sapiens (human) | IC50 | 168.4000 | 1 | 1 |
| isoliquiritigenin | Homo sapiens (human) | IC50 | 55.0000 | 2 | 2 |
| cefsulodin | Homo sapiens (human) | IC50 | 190.0000 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | IC50 | 3.0600 | 1 | 1 |
| 2-aminochromone-3-carboxaldehyde | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| chlorogenic acid | Homo sapiens (human) | IC50 | 5.6000 | 2 | 2 |
| chlorogenic acid | Homo sapiens (human) | Ki | 4,107.5500 | 2 | 2 |
| tocopherylquinone | Homo sapiens (human) | IC50 | 3.8500 | 1 | 1 |
| nsc 117199 | Homo sapiens (human) | IC50 | 96.7000 | 1 | 1 |
| alizarin red s | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 23.3000 | 2 | 2 |
| trans-phytol | Homo sapiens (human) | IC50 | 32.6000 | 1 | 1 |
| 5'-o-caffeoylquinic acid | Homo sapiens (human) | IC50 | 31.6000 | 1 | 1 |
| isobavachalcone | Homo sapiens (human) | IC50 | 27.3000 | 1 | 1 |
| eupatoriopicrine | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| amentoflavone | Homo sapiens (human) | IC50 | 7.4000 | 1 | 1 |
| amentoflavone | Homo sapiens (human) | Ki | 7.8000 | 1 | 1 |
| cupressuflavone | Homo sapiens (human) | IC50 | 9.6000 | 1 | 1 |
| cupressuflavone | Homo sapiens (human) | Ki | 10.7000 | 1 | 1 |
| euxanthone | Homo sapiens (human) | IC50 | 149.9000 | 1 | 1 |
| mangostin | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| mangostin | Homo sapiens (human) | Ki | 3.2000 | 1 | 1 |
| morusin | Homo sapiens (human) | IC50 | 16.2100 | 2 | 2 |
| robustaflavone | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
| robustaflavone | Homo sapiens (human) | Ki | 6.8000 | 1 | 1 |
| trans-2,3',4,5'-tetrahydroxystilbene | Homo sapiens (human) | IC50 | 27.1300 | 1 | 1 |
| chicoric acid | Homo sapiens (human) | Ki | 1,400.0000 | 1 | 1 |
| 3,4-di-o-caffeoylquinic acid | Homo sapiens (human) | IC50 | 41.5000 | 1 | 1 |
| calyculin a | Homo sapiens (human) | IC50 | 0.0008 | 2 | 2 |
| eurycarpin b | Homo sapiens (human) | IC50 | 66.3000 | 1 | 1 |
| glycycoumarin | Homo sapiens (human) | IC50 | 183.9000 | 1 | 1 |
| licochalcone a | Homo sapiens (human) | IC50 | 19.1000 | 3 | 3 |
| Licoflavone A | Homo sapiens (human) | IC50 | 54.5000 | 1 | 1 |
| muromonab-cd3 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| caulerpin | Homo sapiens (human) | IC50 | 3.7700 | 1 | 1 |
| auriculasin | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| auriculasin | Homo sapiens (human) | Ki | 4.4000 | 1 | 1 |
| 2-amino-6-chloropurine | Homo sapiens (human) | IC50 | 75.9400 | 1 | 5 |
| grifolin | Homo sapiens (human) | IC50 | 5.7000 | 1 | 1 |
| gamma-mangostin | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| gamma-mangostin | Homo sapiens (human) | Ki | 2.7000 | 1 | 1 |
| Norartocarpetin | Homo sapiens (human) | IC50 | 5.1800 | 1 | 1 |
| alpinumisoflavone | Homo sapiens (human) | IC50 | 41.5000 | 1 | 1 |
| 4-hydroxylonchocarpin | Homo sapiens (human) | IC50 | 74.1000 | 1 | 1 |
| broussochalcone a | Homo sapiens (human) | IC50 | 29.1500 | 2 | 2 |
| calyculin c | Homo sapiens (human) | IC50 | 0.0015 | 1 | 1 |
| 4,5-di-O-caffeoylquinic acid | Homo sapiens (human) | IC50 | 59.4000 | 1 | 1 |
| indigo carmine | Homo sapiens (human) | IC50 | 37.9000 | 1 | 1 |
| corosolic acid | Homo sapiens (human) | IC50 | 6.2450 | 2 | 2 |
| licochalcone c | Homo sapiens (human) | IC50 | 43.9500 | 2 | 2 |
| 11-keto-boswellic acid | Homo sapiens (human) | IC50 | 8.0400 | 1 | 1 |
| gambogic acid | Homo sapiens (human) | IC50 | 0.4700 | 1 | 1 |
| gambogic acid | Homo sapiens (human) | Ki | 0.3445 | 2 | 2 |
| msi 1436 | Homo sapiens (human) | IC50 | 1.0600 | 5 | 5 |
| methyl 3,5-di-o-caffeoyl quinate | Homo sapiens (human) | IC50 | 42.7000 | 1 | 1 |
| thonningianin a | Homo sapiens (human) | IC50 | 4.4000 | 1 | 1 |
| biapigenin | Homo sapiens (human) | IC50 | 4.5000 | 1 | 1 |
| biapigenin | Homo sapiens (human) | Ki | 4.6000 | 1 | 1 |
| Kanzonol B | Homo sapiens (human) | IC50 | 44.3000 | 1 | 1 |
| protopanaxadiol, (3beta,12beta)-isomer | Homo sapiens (human) | IC50 | 23.6000 | 1 | 1 |
| malbrancheamide | Homo sapiens (human) | IC50 | 14.5000 | 1 | 1 |
| glabrol | Homo sapiens (human) | IC50 | 14.2700 | 3 | 3 |
| 3-epioleanolic acid | Homo sapiens (human) | IC50 | 5.0500 | 1 | 1 |
| oleanonic acid | Homo sapiens (human) | IC50 | 4.4100 | 2 | 2 |
| rutundic acid | Homo sapiens (human) | IC50 | 20.1000 | 1 | 1 |
| odoratin | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
| 23-hydroxyursolic acid | Homo sapiens (human) | IC50 | 7.4000 | 2 | 2 |
| Moracin P | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| augustic acid | Homo sapiens (human) | IC50 | 4.9300 | 1 | 1 |
| isoangustone a | Homo sapiens (human) | IC50 | 5.3500 | 2 | 2 |
| cudraflavanone a | Homo sapiens (human) | IC50 | 4.3100 | 1 | 1 |
| zedoarondiol | Homo sapiens (human) | IC50 | 35.1000 | 1 | 1 |
| 3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid | Homo sapiens (human) | IC50 | 14.3000 | 1 | 1 |
| epi-maslinic acid | Homo sapiens (human) | IC50 | 14.3300 | 1 | 1 |
| 3beta,6beta-dihydroxyolean-12-en-27-oic acid | Homo sapiens (human) | IC50 | 12.8000 | 1 | 1 |
| taiwaniaflavone | Homo sapiens (human) | IC50 | 5.4000 | 1 | 1 |
| taiwaniaflavone | Homo sapiens (human) | Ki | 4.5000 | 1 | 1 |
| formylchromone | Homo sapiens (human) | Ki | 27.6500 | 2 | 2 |
| licochalcone e | Homo sapiens (human) | IC50 | 12.3500 | 2 | 2 |
| rk 682 | Homo sapiens (human) | IC50 | 6.3674 | 21 | 21 |
| variabilin | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| rk 682 | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| imbricatolic acid | Homo sapiens (human) | IC50 | 8.8000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 20, Issue:6, 2012
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Structure-based discovery of small molecule inhibitors targeted to protein tyrosine phosphatase 1B.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: Hologram QSAR for OBA and BBB analogues.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 20, Issue:11, 2010
Molecular docking and 3D-QSAR on 2-(oxalylamino) benzoic acid and its analogues as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 15, Issue:24, 2005
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
Fragment Linking Strategies for Structure-Based Drug Design.Journal of medicinal chemistry, , 10-22, Volume: 63, Issue:20, 2020
Fragment-based drug discovery.Journal of medicinal chemistry, , Jul-01, Volume: 47, Issue:14, 2004
Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.Journal of medicinal chemistry, , Jul-31, Volume: 46, Issue:16, 2003
Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
[no title available]Journal of natural products, , 08-27, Volume: 84, Issue:8, 2021
Germacrane sesquiterpenes from leaves of Eupatorium chinense inhibit protein tyrosine phosphatase.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 53, 2021
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 30, Issue:11, 2020
Spirobiflavonoid stereoisomers from the endangered conifer Glyptostrobus pensilis and their protein tyrosine phosphatase 1B inhibitory activity.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 30, Issue:4, 2020
Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B).Bioorganic & medicinal chemistry letters, , 08-15, Volume: 29, Issue:16, 2019
Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 29, Issue:10, 2019
Protein Tyrosine Phosphatase 1B Inhibitory Iridoids from Journal of natural products, , 10-25, Volume: 82, Issue:10, 2019
Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.European journal of medicinal chemistry, , Jun-15, Volume: 172, 2019
[no title available]Journal of natural products, , 12-27, Volume: 82, Issue:12, 2019
Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense.Journal of natural products, , 08-24, Volume: 81, Issue:8, 2018
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 27, Issue:5, 2017
Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. Marine Sponge.Journal of natural products, , 09-22, Volume: 80, Issue:9, 2017
Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 27, Issue:23, 2017
Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 27, Issue:4, 2017
Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana.Journal of natural products, , 11-22, Volume: 80, Issue:11, 2017
Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.European journal of medicinal chemistry, , Oct-21, Volume: 122, 2016
Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.European journal of medicinal chemistry, , Aug-08, Volume: 118, 2016
Eucarobustols A-I, Conjugates of Sesquiterpenoids and Acylphloroglucinols from Eucalyptus robusta.Journal of natural products, , 05-27, Volume: 79, Issue:5, 2016
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against protein tyrosine phosphatase 1B.Chemical biology & drug design, , Volume: 86, Issue:5, 2015
Bioactive constituents from the green alga Caulerpa racemosa.Bioorganic & medicinal chemistry, , Jan-01, Volume: 23, Issue:1, 2015
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Two new protein tyrosine phosphatase 1B inhibitors, hyattellactones A and B, from the Indonesian marine sponge Hyattella sp.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 25, Issue:4, 2015
Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10, 2015
Structures and Biological Evaluations of Agelasines Isolated from the Okinawan Marine Sponge Agelas nakamurai.Journal of natural products, , Jun-26, Volume: 78, Issue:6, 2015
Strongylophorines, new protein tyrosine phosphatase 1B inhibitors, from the marine sponge Strongylophora strongilata collected at Iriomote Island.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an Indonesian ascidian-derived Penicillium verruculosum.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 23, Issue:18, 2013
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.European journal of medicinal chemistry, , Volume: 69, 2013
Euryspongins A-C, three new unique sesquiterpenes from a marine sponge Euryspongia sp.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 23, Issue:7, 2013
Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 23, Issue:5, 2013
Structure and bioassay of triterpenoids and steroids isolated from Sinocalamus affinis.Journal of natural products, , Jun-22, Volume: 75, Issue:6, 2012
Cucurbitane glucosides from the root of Machilus yaoshansis.Journal of natural products, , Nov-28, Volume: 74, Issue:11, 2011
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Chemical Constituents of the Roots of Euphorbia micractina.Journal of natural products, , Volume: 72, Issue:9, 2009
Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.Journal of natural products, , Volume: 71, Issue:10, 2008
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 16, Issue:12, 2006
Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of Journal of natural products, , 02-28, Volume: 83, Issue:2, 2020
[no title available]Journal of natural products, , 04-24, Volume: 83, Issue:4, 2020
Hydroxy-Journal of natural products, , 07-24, Volume: 83, Issue:7, 2020
[no title available]Journal of natural products, , 03-27, Volume: 83, Issue:3, 2020
Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Dihydrochalcone Glucosides from the Subaerial Parts of Thonningia sanguinea and Their in Vitro PTP1B Inhibitory Activities.Journal of natural products, , 09-28, Volume: 81, Issue:9, 2018
Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 28, Issue:7, 2018
Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Structure-related protein tyrosine phosphatase 1B inhibition by naringenin derivatives.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 27, Issue:11, 2017
[no title available]Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds.Journal of natural products, , 02-24, Volume: 80, Issue:2, 2017
Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.Journal of natural products, , Feb-26, Volume: 79, Issue:2, 2016
Insulin-mimetic selaginellins from Selaginella tamariscina with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.Journal of natural products, , Jan-23, Volume: 78, Issue:1, 2015
Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity.Journal of natural products, , Nov-22, Volume: 76, Issue:11, 2013
Sesquiterpenes from the rhizomes of Curcuma heyneana.Journal of natural products, , Feb-22, Volume: 76, Issue:2, 2013
New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae.Bioorganic & medicinal chemistry, , Nov-01, Volume: 20, Issue:21, 2012
New diterpene furanoids from the Antarctic lichen Huea sp.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 22, Issue:24, 2012
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 22, Issue:19, 2012
Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009
Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.Journal of natural products, , Volume: 71, Issue:10, 2008
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Flavanones from the stem bark of Erythrina abyssinica.Bioorganic & medicinal chemistry, , Dec-15, Volume: 16, Issue:24, 2008
Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.Journal of natural products, , Volume: 70, Issue:6, 2007
Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.Journal of natural products, , Volume: 69, Issue:11, 2006
Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum.Journal of natural products, , 06-22, Volume: 81, Issue:6, 2018
Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.Bioorganic & medicinal chemistry, , Jan-15, Volume: 20, Issue:2, 2012
Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.Journal of natural products, , Volume: 69, Issue:11, 2006
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.Journal of medicinal chemistry, , 12-27, Volume: 61, Issue:24, 2018
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from Journal of natural products, , 09-24, Volume: 84, Issue:9, 2021
PTP1B-Inhibiting Branched-Chain Fatty Acid Dimers from Journal of natural products, , 05-22, Volume: 83, Issue:5, 2020
Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.European journal of medicinal chemistry, , Oct-21, Volume: 122, 2016
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Bioorganic & medicinal chemistry, , Jun-15, Volume: 23, Issue:12, 2015
Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.Bioorganic & medicinal chemistry, , Jan-15, Volume: 20, Issue:2, 2012
Using small molecules to target protein phosphatases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009
Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:8, 2009
Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta).Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 17, Issue:19, 2007
Pyrrolo[1,2-a]quinoxal-5-inium salts and 4,5-dihydropyrrolo[1,2-a]quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana.Journal of natural products, , 11-22, Volume: 80, Issue:11, 2017
Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: Hologram QSAR for OBA and BBB analogues.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 20, Issue:11, 2010
Molecular docking and 3D-QSAR on 2-(oxalylamino) benzoic acid and its analogues as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 15, Issue:24, 2005
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of Journal of natural products, , 02-28, Volume: 83, Issue:2, 2020
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
The first two cantharidin analogues displaying PP1 selectivity.Bioorganic & medicinal chemistry letters, , Feb-11, Volume: 12, Issue:3, 2002
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.Journal of medicinal chemistry, , Sep-26, Volume: 40, Issue:20, 1997
[no title available]Journal of natural products, , 04-24, Volume: 83, Issue:4, 2020
Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
[no title available]Journal of natural products, , 04-24, Volume: 83, Issue:4, 2020
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 23, Issue:21, 2013
In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Pyrrolo[1,2-a]quinoxal-5-inium salts and 4,5-dihydropyrrolo[1,2-a]quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 28, Issue:7, 2018
Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid.Biochemistry, , Jan-10, Volume: 56, Issue:1, 2017
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 17, Issue:7, 2009
Natural PTP1B inhibitors from Broussonetia papyrifera.Bioorganic & medicinal chemistry letters, , Dec-02, Volume: 12, Issue:23, 2002
The first two cantharidin analogues displaying PP1 selectivity.Bioorganic & medicinal chemistry letters, , Feb-11, Volume: 12, Issue:3, 2002
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.Journal of medicinal chemistry, , Sep-26, Volume: 40, Issue:20, 1997
Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 22, Issue:19, 2012
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 23, Issue:21, 2013
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from Journal of natural products, , 09-24, Volume: 84, Issue:9, 2021
PTP1B-Inhibiting Branched-Chain Fatty Acid Dimers from Journal of natural products, , 05-22, Volume: 83, Issue:5, 2020
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Bioorganic & medicinal chemistry, , Jun-15, Volume: 23, Issue:12, 2015
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Using small molecules to target protein phosphatases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.Journal of natural products, , 02-24, Volume: 80, Issue:2, 2017
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 23, Issue:21, 2013
Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR.Journal of natural products, , Apr-22, Volume: 79, Issue:4, 2016
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 22, Issue:19, 2012
[no title available]Journal of natural products, , 04-24, Volume: 83, Issue:4, 2020
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.Journal of natural products, , Feb-26, Volume: 79, Issue:2, 2016
Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
PTP1B-Inhibiting Branched-Chain Fatty Acid Dimers from Journal of natural products, , 05-22, Volume: 83, Issue:5, 2020
[no title available]Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR.Journal of natural products, , Apr-22, Volume: 79, Issue:4, 2016
Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , May-01, Volume: 25, Issue:9, 2015
Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 23, Issue:21, 2013
Sesquiterpenes from the rhizomes of Curcuma heyneana.Journal of natural products, , Feb-22, Volume: 76, Issue:2, 2013
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 22, Issue:19, 2012
Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.Journal of natural products, , Volume: 71, Issue:10, 2008
Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum.Journal of natural products, , Volume: 71, Issue:4, 2008
Flavanones from the stem bark of Erythrina abyssinica.Bioorganic & medicinal chemistry, , Dec-15, Volume: 16, Issue:24, 2008
Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.Journal of natural products, , Volume: 70, Issue:6, 2007
Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 17, Issue:16, 2007
Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.Journal of natural products, , Volume: 69, Issue:11, 2006
Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 16, Issue:12, 2006
Protein tyrosine phosphatase 1B inhibitors from Morus root bark.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 16, Issue:5, 2006
Enables
This protein enables 12 target(s):
| Target | Category | Definition |
|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| insulin receptor binding | molecular function | Binding to an insulin receptor. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| enzyme binding | molecular function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| receptor tyrosine kinase binding | molecular function | Binding to a receptor that possesses protein tyrosine kinase activity. [GOC:mah] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
| ephrin receptor binding | molecular function | Binding to an ephrin receptor. [GOC:ai] |
| protein phosphatase 2A binding | molecular function | Binding to protein phosphatase 2A. [GOC:ai] |
| non-membrane spanning protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48] |
Located In
This protein is located in 9 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
| early endosome | cellular component | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| mitochondrial crista | cellular component | Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria. [ISBN:0198506732] |
| endosome lumen | cellular component | The volume enclosed by the membrane of an endosome. [GOC:mah] |
| sorting endosome | cellular component | A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles. [NIF_Subcellular:sao1028571114] |
| cytoplasmic side of endoplasmic reticulum membrane | cellular component | The side (leaflet) of the plasma membrane that faces the cytoplasm. [GOC:ab, GOC:dos] |
Active In
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| early endosome | cellular component | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| protein-containing complex | cellular component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
Involved In
This protein is involved in 26 target(s):
| Target | Category | Definition |
|---|
| protein dephosphorylation | biological process | The process of removing one or more phosphoric residues from a protein. [GOC:hb] |
| insulin receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. [GOC:ceb] |
| regulation of signal transduction | biological process | Any process that modulates the frequency, rate or extent of signal transduction. [GOC:sm] |
| negative regulation of signal transduction | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. [GOC:sm] |
| actin cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah] |
| regulation of endocytosis | biological process | Any process that modulates the frequency, rate or extent of endocytosis. [GOC:go_curators] |
| negative regulation of vascular endothelial growth factor receptor signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. [GOC:dgh] |
| endoplasmic reticulum unfolded protein response | biological process | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. [GOC:mah, PMID:12042763] |
| regulation of intracellular protein transport | biological process | Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. [GOC:mah] |
| cellular response to unfolded protein | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. [GOC:mah] |
| peptidyl-tyrosine dephosphorylation | biological process | The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf] |
| platelet-derived growth factor receptor-beta signaling pathway | biological process | The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961] |
| IRE1-mediated unfolded protein response | biological process | The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. [GOC:bf, GOC:PARL, PMID:22013210] |
| insulin receptor recycling | biological process | The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. [GOC:bf, GOC:signaling, PMID:3907718] |
| negative regulation of MAP kinase activity | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators] |
| negative regulation of insulin receptor signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. [GOC:bf] |
| regulation of type I interferon-mediated signaling pathway | biological process | Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph] |
| growth hormone receptor signaling pathway via JAK-STAT | biological process | The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. [GOC:BHF, GOC:dph, PMID:11445442] |
| positive regulation of protein tyrosine kinase activity | biological process | Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb] |
| negative regulation of ERK1 and ERK2 cascade | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986] |
| regulation of hepatocyte growth factor receptor signaling pathway | biological process | Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. [GOC:TermGenie, PMID:18819921] |
| negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] |
| positive regulation of IRE1-mediated unfolded protein response | biological process | Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] |
| negative regulation of PERK-mediated unfolded protein response | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] |
| peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity | biological process | Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity. [PMID:7501024] |
| positive regulation of receptor catabolic process | biological process | Any process that activates or increases the frequency, rate or extent of receptor catabolic process. [GOC:BHF] |