Proteins > Hydroxycarboxylic acid receptor 3
Page last updated: 2024-08-07 13:19:17
Hydroxycarboxylic acid receptor 3
A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49019]
Synonyms
G-protein coupled receptor 109B;
G-protein coupled receptor HM74;
G-protein coupled receptor HM74B;
Niacin receptor 2;
Nicotinic acid receptor 2
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| acifran | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
Drugs with Activation Measurements
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.ACS medicinal chemistry letters, , Jan-12, Volume: 3, Issue:1, 2012
Discovery of a potent nicotinic Acid receptor agonist for the treatment of dyslipidemia.ACS medicinal chemistry letters, , Feb-10, Volume: 2, Issue:2, 2011
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 17, Issue:20, 2007
Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists.Bioorganic & medicinal chemistry, , Jul-15, Volume: 23, Issue:14, 2015
5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Nicotinic acid receptor agonists.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| nicotinic acid receptor activity | molecular function | Combining with nicotinic acid to initiate a change in cell activity. [GOC:mah, PMID:12522134] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell junction | cellular component | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |