Sphingosine kinase 2

A sphingosine kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRA0]

Synonyms

SK 2;
SPK 2;
EC 2.7.1.91

Research

Bioassay Publications (25)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (8.00)	29.6817
2010's	14 (56.00)	24.3611
2020's	9 (36.00)	2.80

Compounds (9)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol	Homo sapiens (human)	IC50	20.0000	2	2
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol	Homo sapiens (human)	Ki	19.7571	7	7
sphingosine	Homo sapiens (human)	IC50	1.5600	1	1
n,n-dimethylsphingenine	Homo sapiens (human)	IC50	42.0967	3	3
n,n-dimethylsphingenine	Homo sapiens (human)	Ki	12.8333	3	3
es-285	Homo sapiens (human)	IC50	766.0000	1	1
3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	Homo sapiens (human)	IC50	60.0000	1	1
3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	Homo sapiens (human)	Ki	9.8429	14	14
bml 258	Homo sapiens (human)	IC50	10.0000	1	1
bml 258	Homo sapiens (human)	Ki	100.0000	1	1
pf-543	Homo sapiens (human)	IC50	6.6395	8	8
pf-543	Homo sapiens (human)	Ki	0.0036	1	1
rome	Homo sapiens (human)	IC50	27.0000	1	1
rome	Homo sapiens (human)	Ki	18.6000	5	5

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
fingolimod hydrochloride	Homo sapiens (human)	Km	23.7000	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
lipid kinase activity	molecular function	Catalysis of the phosphorylation of a simple or complex lipid. [GOC:hjd]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
sphinganine kinase activity	molecular function	Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. [EC:2.7.1.91]
D-erythro-sphingosine kinase activity	molecular function	Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. [MetaCyc:RXN3DJ-11417]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]
sphingosine-1-phosphate receptor activity	molecular function	Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, PMID:12728273, Wikipedia:S1PR1]
histone binding	molecular function	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]

Located In

This protein is located in 9 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
nucleosome	cellular component	A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:elh]

Involved In

This protein is involved in 27 target(s):

Target	Category	Definition
blood vessel development	biological process	The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. [GOC:hjd, UBERON:0001981]
positive regulation of cytokine production involved in immune response	biological process	Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. [GOC:add]
sphingosine-1-phosphate receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186, Reactome:R-HSA-419428]
sphinganine-1-phosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. [GOC:ai]
sphingosine metabolic process	biological process	The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. [GOC:ma, ISBN:0198506732]
brain development	biological process	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
cell population proliferation	biological process	The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
sphingolipid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732]
negative regulation of cell growth	biological process	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
positive regulation of interleukin-13 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. [GOC:mah]
positive regulation of interleukin-6 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
positive regulation of tumor necrosis factor production	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
positive regulation of mast cell activation involved in immune response	biological process	Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. [GOC:mah]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
regulation of canonical NF-kappaB signal transduction	biological process	Any process that modulates the canonical NF-kappaB signaling cascade. [GOC:jl, PMID:12773372]
positive regulation of mast cell degranulation	biological process	Any process that activates or increases the frequency, rate or extent of mast cell degranulation. [ISBN:0781735149]
transcription initiation-coupled chromatin remodeling	biological process	An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. [PMID:34414474]
sphingosine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. [GOC:ma, ISBN:0198506732]
positive regulation of protein kinase C signaling	biological process	Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. [GOC:dph, GOC:tb]
positive regulation of calcium ion import	biological process	Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]
regulation of reactive oxygen species biosynthetic process	biological process	Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
cellular response to phorbol 13-acetate 12-myristate	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:2200903]
regulation of cytochrome-c oxidase activity	biological process	Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity. [GO_REF:0000059, GOC:TermGenie, PMID:26734017]
positive regulation of ceramide biosynthetic process	biological process	Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process. [GOC:dph]
regulation of ATP biosynthetic process	biological process	Any process that modulates the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]
phosphorylation	biological process	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732]