Compounds > renieramycin m
Page last updated: 2024-11-12

renieramycin m

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

renieramycin M: from the Thai sponge Xestospongia sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10483239
CHEMBL ID451147
SCHEMBL ID21357942
MeSH IDM0462101

Synonyms (4)

Synonym
renieramycin m
CHEMBL451147
SCHEMBL21357942
[(1r,2s,10r,12r,13s)-12-cyano-7,18-dimethoxy-6,17,21-trimethyl-5,8,16,19-tetraoxo-11,21-diazapentacyclo[11.7.1.02,11.04,9.015,20]henicosa-4(9),6,15(20),17-tetraen-10-yl]methyl (z)-2-methylbut-2-enoate

Research Excerpts

Effects

ExcerptReferenceRelevance
"Renieramycin M, has been shown to exhibit promising anticancer activity against some cancer cell lines; however, the underlying mechanism remains unknown."( Anticancer and antimetastatic activities of Renieramycin M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells.
Chanvorachote, P; Chunhacha, P; Halim, H; Suwanborirux, K, 2011)		2.07

Treatment

ExcerptReferenceRelevance
"Renieramycin M treatment caused p53 activation, which subsequently down-regulated anti-apoptotic MCL-1 and BCL-2 proteins, while the level of pro-apoptotic BAX protein was not altered. "( Anticancer and antimetastatic activities of Renieramycin M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells.
Chanvorachote, P; Chunhacha, P; Halim, H; Suwanborirux, K, 2011)		2.07
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID762953Cytotoxicity against human H23 cells assessed as cell viability after 24 hrs by MTT assay2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID1871290Cytotoxicity against human ASPC1 cells assessed as cell growth inhibition2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID762949Induction of accidental necrosis in human H23 cells assessed as loss of membrane integrity at 5 to 20 uM after 24 hrs by trypan blue exclusion assay2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID1871270Growth inhibition of human DU-145 cells2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID1871284Cytotoxicity against human DLD-1 cells assessed as cell growth inhibition2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID356601Cytotoxicity against human QG56 cells after 4 days2003Journal of natural products, Nov, Volume: 66, Issue:11
Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
AID762950Induction of apoptosis in human H23 cells assessed as accumulation of sub-G0 fraction after 24 hrs by propidium iodide staining-based flow cytometry2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID356602Cytotoxicity against human NCI-H460 cells after 4 days2003Journal of natural products, Nov, Volume: 66, Issue:11
Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
AID1871287Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition by MTT colorimetric assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID1871286Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition by MTT colorimetric assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID762943Induction of intracellular H2O2 generation in human H23 cells at 20 uM after 6 hrs by DCFH2-DA staining based fluorescence assay in presence of sodium pyruvate2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID1871276Cytotoxicity against human U373 MG cells assessed as cell growth inhibition incubated for 4 to 72 hrs by MTT assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID356603Cytotoxicity against human DLD1 cells after 4 days2003Journal of natural products, Nov, Volume: 66, Issue:11
Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
AID762941Induction of intracellular superoxide anion generation in human H23 cells at 20 uM after 6 hrs by DCFH2-DA staining based fluorescence assay in presence of dihydroethidium relative to control2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID762945Induction of intracellular ROS generation in human H23 cells at 20 uM after 6 hrs by DCFH2-DA staining based fluorescence assay2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID1871283Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID427235Cytotoxicity against human HCT116 cells after 3 days by MTT assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Chemistry of renieramycins. Part 8: synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues.
AID762946Induction of ROS generation in human H23 cells assessed as apoptotic cells at 20 uM after 24 hrs by Hoechst 33342/propidium iodide staining-based fluorescence microscopy in presence of N-acetylcysteine2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID762947Induction of ROS generation in human H23 cells assessed as accidental necrotic cells at 20 uM after 24 hrs by Hoechst 33342/propidium iodide staining-based fluorescence microscopy in presence of N-acetylcysteine2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID762944Induction of intracellular ROS generation in human H23 cells at 20 uM after 6 hrs by DCFH2-DA staining based fluorescence assay in presence of N-acetylcysteine2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID402913Cytotoxicity against human QG56 cells after 4 days2004Journal of natural products, Jun, Volume: 67, Issue:6
Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide.
AID1871282Cytotoxicity against human QG-56 cells assessed as cell growth inhibition2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID402912Cytotoxicity against human HCT116 cells after 4 days2004Journal of natural products, Jun, Volume: 67, Issue:6
Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide.
AID762948Induction of ROS generation in human H23 cells assessed as cell viability at 20 uM after 24 hrs by Hoechst 33342/propidium iodide staining-based fluorescence microscopy in presence of N-acetylcysteine2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID762952Induction of apoptosis in human H23 cells at 1 to 20 uM after 24 hrs by Hoechst 33342/propidium iodide staining-based fluorescence microscopy2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID356600Cytotoxicity against human HCT116 cells after 4 days2003Journal of natural products, Nov, Volume: 66, Issue:11
Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
AID1871269Growth inhibition of human HCT-116 cells2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID1871296Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 4 days by Cell counting kit-8 assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID762942Induction of intracellular hydroxyl radical generation in human H23 cells at 20 uM after 6 hrs by DCFH2-DA staining based fluorescence assay in presence of HPF2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID1871281Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID1871288Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID427236Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Chemistry of renieramycins. Part 8: synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues.
AID762939Toxicity in human HK2 cells assessed as induction of accidental necrosis at 20 uM after 24 hrs by propidium iodide staining2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID762951Toxicity in human H23 cells assessed as induction of accidental necrosis at 1 to 20 uM after 24 hrs by Hoechst 33342/propidium iodide staining-based fluorescence microscopy2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
AID1871268Growth inhibition of human QG-56 cells2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID1871285Cytotoxicity against human T47D cells assessed as cell growth inhibition2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
AID1871297Cytotoxicity against human QG-56 cells assessed as cell growth inhibition incubated for 4 days by Cell counting kit-8 assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (26.32)29.6817
2010's9 (47.37)24.3611
2020's5 (26.32)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.85 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.84 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycine
[no description available]		7.3110alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		2.5820monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
potassium cyanide
[no description available]		2.0110cyanide salt;
one-carbon compound;
potassium salt		EC 1.15.1.1 (superoxide dismutase) inhibitor;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
neurotoxin
aziridine
[no description available]		7.0510azacycloalkane;
aziridines;
saturated organic heteromonocyclic parent		alkylating agent
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.0810acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
saframycin a
saframycin A: structure given in first source		2.0110
bortezomib
[no description available]		3.4110amino acid amide;
L-phenylalanine derivative;
pyrazines		antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor
doxorubicin hydrochloride
[no description available]		3.4110anthracycline
jorumycin
jorumycin: structure in first source		8.8730
ecteinascidin 770
ecteinascidin 770: fom the Thai tunicate Ecteinascidia thurstoni; structure in first source		2.0110
jorunnamycin a
jorunnamycin A: structure in first source		2.830isoquinolines
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		07.520
Carcinoma, Anaplastic
[description not available]		02.0510
Cancer of Colon
[description not available]		02.0510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.520
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0510
Cancer of Lung
[description not available]		03.7590
Lung Neoplasms
Tumors or cancer of the LUNG.		03.7590
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		07.0810
Benign Neoplasms
[description not available]		03.2310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.2310
Carcinoma, Non-Small Cell Lung
[description not available]		03.2350
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		03.2350