A cytochrome P450 4F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78329]
EC 1.14.14.1;
20-hydroxyeicosatetraenoic acid synthase;
20-HETE synthase;
Arachidonic acid omega-hydroxylase;
CYPIVF2;
Cytochrome P450-LTB-omega;
Docosahexaenoic acid omega-hydroxylase;
1.14.14.79;
Leukotriene-B(4) 20-mono
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 4 (66.67) | 24.3611 |
2020's | 2 (33.33) | 2.80 |
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
17-octadecynoic acid | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
ketoconazole | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
tranylcypromine | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
proadifen hydrochloride | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
pirlindole | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
kaf156 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
This protein enables 15 target(s):
Target | Category | Definition |
---|---|---|
monooxygenase activity | molecular function | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732] |
iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
arachidonic acid epoxygenase activity | molecular function | Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, PMID:18952572] |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | molecular function | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah] |
alkane 1-monooxygenase activity | molecular function | Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. [EC:1.14.15.3] |
heme binding | molecular function | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai] |
leukotriene-B4 20-monooxygenase activity | molecular function | Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [PMID:11461919, PMID:15364545, PMID:8486631, PMID:9675028, RHEA:22176] |
arachidonic acid omega-hydroxylase activity | molecular function | Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid. [KEGG_REACTION:R07041] |
alpha-tocopherol omega-hydroxylase activity | molecular function | Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O . [MetaCyc:RXN-11003] |
tocotrienol omega-hydroxylase activity | molecular function | Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O . [MetaCyc:RXN-11003] |
aromatase activity | molecular function | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. [GOC:cb] |
20-hydroxy-leukotriene B4 omega oxidase activity | molecular function | Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]. [GOC:mw, PMID:2836406, PMID:9675028, RHEA:48668] |
20-aldehyde-leukotriene B4 20-monooxygenase activity | molecular function | Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [GOC:mw, PMID:2549038, PMID:2836406, PMID:9675028, RHEA:48672] |
long-chain fatty acid omega-hydroxylase activity | molecular function | Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:krc, PMID:18544608, RHEA:56748] |
This protein is located in 4 target(s):
Target | Category | Definition |
---|---|---|
cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
This protein is involved in 21 target(s):
Target | Category | Definition |
---|---|---|
very long-chain fatty acid metabolic process | biological process | The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. [GOC:hjd] |
long-chain fatty acid metabolic process | biological process | The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ajp] |
renal water homeostasis | biological process | Renal process involved in the maintenance of an internal steady state of water in the body. [GOC:mtg_cardio] |
pressure natriuresis | biological process | The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis). [GOC:mtg_cardio] |
icosanoid metabolic process | biological process | The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. [GOC:ma] |
leukotriene metabolic process | biological process | The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:ma] |
xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
blood coagulation | biological process | The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128] |
regulation of blood pressure | biological process | Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949] |
fatty acid omega-oxidation | biological process | A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation. [MetaCyc:PWY-2724, PMID:16404574] |
arachidonic acid metabolic process | biological process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732] |
epoxygenase P450 pathway | biological process | The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. [GOC:mah, PMID:17979511] |
negative regulation of icosanoid secretion | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell. [GOC:mah] |
positive regulation of icosanoid secretion | biological process | Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell. [GOC:mah] |
leukotriene B4 catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. [GOC:yaf, PMID:9799565] |
vitamin E metabolic process | biological process | The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. [GOC:jl, ISBN:0198506732] |
menaquinone catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] |
phylloquinone catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] |
vitamin K catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] |
sodium ion homeostasis | biological process | Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah] |
omega-hydroxylase P450 pathway | biological process | The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. [GOC:mw, PMID:10681399] |