An aspartyl/asparaginyl beta-hydroxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12797]
EC 1.14.11.16;
Aspartate beta-hydroxylase;
ASP beta-hydroxylase;
Peptide-aspartate beta-dioxygenase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gossypol | Homo sapiens (human) | IC50 | 0.2725 | 4 | 4 |
| 2,4-pyridinedicarboxylic acid | Homo sapiens (human) | IC50 | 0.0425 | 4 | 4 |
| bleomycin | Homo sapiens (human) | IC50 | 2.2300 | 4 | 4 |
| tubacin | Homo sapiens (human) | IC50 | 4.5725 | 4 | 4 |
| belinostat | Homo sapiens (human) | IC50 | 6.6400 | 4 | 4 |
| midostaurin | Homo sapiens (human) | IC50 | 8.7825 | 4 | 4 |
| abt-737 | Homo sapiens (human) | IC50 | 3.4400 | 4 | 4 |
| navitoclax | Homo sapiens (human) | IC50 | 1.0925 | 4 | 4 |
| plx4032 | Homo sapiens (human) | IC50 | 13.8500 | 4 | 4 |
| abt-199 | Homo sapiens (human) | IC50 | 1.4450 | 4 | 4 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| structural molecule activity | molecular function | The action of a molecule that contributes to the structural integrity of a complex. [GOC:mah, GOC:vw] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| structural constituent of muscle | molecular function | The action of a molecule that contributes to the structural integrity of a muscle fiber. [GOC:mah] |
| electron transfer activity | molecular function | A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer] |
| peptidyl-aspartic acid 3-dioxygenase activity | molecular function | Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2. [PMID:1378441, PMID:1856229, RHEA:11508] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cortical endoplasmic reticulum | cellular component | A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. [GOC:se, PMID:10931860, PMID:17686782] |
| sarcoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the sarcoplasmic reticulum. [GOC:rph] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
This protein is involved in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| muscle contraction | biological process | A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] |
| pattern specification process | biological process | Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] |
| cell population proliferation | biological process | The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb] |
| negative regulation of cell population proliferation | biological process | Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators] |
| regulation of protein stability | biological process | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. [GOC:dph, GOC:mah, GOC:tb] |
| limb morphogenesis | biological process | The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping. [UBERON:0002101] |
| positive regulation of proteolysis | biological process | Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators] |
| roof of mouth development | biological process | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. [GOC:dph, ISBN:0721662544] |
| face morphogenesis | biological process | The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. [GOC:dph] |
| activation of cysteine-type endopeptidase activity | biological process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. [GOC:mtg_apoptosis, PMID:21726810] |
| regulation of protein depolymerization | biological process | Any process that modulates the frequency, rate or extent of protein depolymerization. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] |
| peptidyl-aspartic acid hydroxylation | biological process | The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid. [GOC:mah] |