Page last updated: 2024-08-07 23:55:30
Mitogen-activated protein kinase kinase kinase 19
A mitogen-activated protein kinase kinase kinase 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q56UN5]
Synonyms
EC 2.7.11.1;
Regulated in COPD, protein kinase;
SPS1/STE20-related protein kinase YSK4
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (70)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| staurosporine | Homo sapiens (human) | IC50 | 0.0087 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| imatinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| staurosporine | Homo sapiens (human) | Kd | 0.0009 | 1 | 1 |
| gefitinib | Homo sapiens (human) | Kd | 0.2400 | 1 | 1 |
| lestaurtinib | Homo sapiens (human) | Kd | 0.0005 | 2 | 2 |
| vatalanib | Homo sapiens (human) | Kd | 1.9000 | 1 | 1 |
| ruboxistaurin | Homo sapiens (human) | Kd | 0.0480 | 1 | 1 |
| canertinib | Homo sapiens (human) | Kd | 0.7000 | 1 | 1 |
| birb 796 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| sb 203580 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| enzastaurin | Homo sapiens (human) | Kd | 1.6000 | 1 | 1 |
| erlotinib | Homo sapiens (human) | Kd | 0.0250 | 1 | 1 |
| lapatinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| sorafenib | Homo sapiens (human) | Kd | 0.0990 | 2 | 2 |
| pd 173955 | Homo sapiens (human) | Kd | 0.2400 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tg 003 | Homo sapiens (human) | Kd | 0.2900 | 1 | 1 |
| bms 387032 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tandutinib | Homo sapiens (human) | Kd | 7.9500 | 2 | 2 |
| vx-745 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| dasatinib | Homo sapiens (human) | Kd | 0.0790 | 1 | 1 |
| zd 6474 | Homo sapiens (human) | Kd | 0.9800 | 1 | 1 |
| alvocidib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bosutinib | Homo sapiens (human) | Kd | 0.0160 | 1 | 1 |
| su 11248 | Homo sapiens (human) | Kd | 0.0170 | 2 | 2 |
| vx680 | Homo sapiens (human) | Kd | 0.0510 | 1 | 1 |
| axitinib | Homo sapiens (human) | Kd | 0.2700 | 1 | 1 |
| pd 184352 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bms345541 | Homo sapiens (human) | Kd | 0.2600 | 1 | 1 |
| midostaurin | Homo sapiens (human) | Kd | 0.0150 | 2 | 2 |
| ki 20227 | Homo sapiens (human) | Kd | 2.4000 | 1 | 1 |
| pi103 | Homo sapiens (human) | Kd | 0.9300 | 1 | 1 |
| hki 272 | Homo sapiens (human) | Kd | 0.0160 | 1 | 1 |
| tofacitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| cediranib | Homo sapiens (human) | Kd | 0.2500 | 1 | 1 |
| masitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pazopanib | Homo sapiens (human) | Kd | 0.9400 | 1 | 1 |
| azd 6244 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| su 14813 | Homo sapiens (human) | Kd | 0.0120 | 1 | 1 |
| bibw 2992 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tg100-115 | Homo sapiens (human) | Kd | 4.0000 | 1 | 1 |
| pha 665752 | Homo sapiens (human) | Kd | 0.0780 | 1 | 1 |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Homo sapiens (human) | Kd | 0.0670 | 1 | 1 |
| brivanib | Homo sapiens (human) | Kd | 0.5000 | 1 | 1 |
| at 7519 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bi 2536 | Homo sapiens (human) | Kd | 0.4800 | 1 | 1 |
| nvp-ast487 | Homo sapiens (human) | Kd | 0.1200 | 1 | 1 |
| kw 2449 | Homo sapiens (human) | Kd | 0.0052 | 1 | 1 |
| abt 869 | Homo sapiens (human) | Kd | 0.2500 | 1 | 1 |
| gw 2580 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| crizotinib | Homo sapiens (human) | Kd | 0.9800 | 1 | 1 |
| chir-265 | Homo sapiens (human) | Kd | 0.0540 | 1 | 1 |
| motesanib | Homo sapiens (human) | Kd | 0.2000 | 1 | 1 |
| mln8054 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| GDC-0879 | Homo sapiens (human) | Kd | 0.9100 | 1 | 1 |
| gsk 461364 | Homo sapiens (human) | Kd | 2.8000 | 1 | 1 |
| azd 1152-hqpa | Homo sapiens (human) | Kd | 2.4000 | 1 | 1 |
| nvp-tae684 | Homo sapiens (human) | Kd | 2.8000 | 1 | 1 |
| fedratinib | Homo sapiens (human) | Kd | 0.0190 | 1 | 1 |
| gsk690693 | Homo sapiens (human) | Kd | 0.0330 | 1 | 1 |
| gdc 0941 | Homo sapiens (human) | Kd | 4.0000 | 1 | 1 |
| plx 4720 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| sgx 523 | Homo sapiens (human) | Kd | 6.4000 | 1 | 1 |
| quizartinib | Homo sapiens (human) | Kd | 2.0000 | 2 | 2 |
| incb-018424 | Homo sapiens (human) | Kd | 0.2700 | 1 | 1 |
| gsk 1838705a | Homo sapiens (human) | Kd | 0.1900 | 1 | 1 |
| gsk 1363089 | Homo sapiens (human) | Kd | 0.0055 | 1 | 1 |
| chir 258 | Homo sapiens (human) | Kd | 0.0120 | 1 | 1 |
| nintedanib | Homo sapiens (human) | Kd | 0.0052 | 1 | 1 |
| pp242 | Homo sapiens (human) | Kd | 0.0051 | 1 | 1 |
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein serine/threonine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| protein serine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989] |