Growth hormone secretagogue receptor type 1

A growth hormone secretagogue receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92847]

Synonyms

GHS-R;
GH-releasing peptide receptor;
GHRP;
Ghrelin receptor

Research

Bioassay Publications (24)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (8.33)	18.2507
2000's	12 (50.00)	29.6817
2010's	8 (33.33)	24.3611
2020's	2 (8.33)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
l 692429	Homo sapiens (human)	IC50	2.8000	1	1
l 692429	Homo sapiens (human)	Ki	0.0630	1	1
l 163191	Homo sapiens (human)	IC50	0.0423	7	8
l 163191	Homo sapiens (human)	Ki	0.0404	2	8
cp 424391	Homo sapiens (human)	IC50	1.0140	2	3
cp 424391	Homo sapiens (human)	Ki	0.0070	1	1
hexarelin	Homo sapiens (human)	IC50	0.0170	2	2
sm 130686	Homo sapiens (human)	IC50	0.0016	2	2
macimorelin	Homo sapiens (human)	IC50	0.0730	2	2
sk&f 110679	Homo sapiens (human)	IC50	2.0032	3	2
sk&f 110679	Homo sapiens (human)	Ki	0.0060	1	1
yil 781	Homo sapiens (human)	Ki	0.0040	1	1
nitd 609	Homo sapiens (human)	IC50	30.0000	1	1
gsk 2334470	Homo sapiens (human)	IC50	24.9050	1	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
substance p	Homo sapiens (human)	EC50	0.0660	1	1
l 163191	Homo sapiens (human)	EC50	0.0008	4	6
l 163191	Homo sapiens (human)	Kd	0.0001	1	1
cp 424391	Homo sapiens (human)	EC50	0.0009	1	2
tabimorelin	Homo sapiens (human)	EC50	0.0030	2	4
l 162752	Homo sapiens (human)	EC50	0.0141	2	4
ulimorelin	Homo sapiens (human)	EC50	0.0110	3	1
n-(3-fluorophenyl)-1-((4-(((3s)-3-methyl-1-piperazinyl)methyl)phenyl)acetyl)-4-piperidinamine	Homo sapiens (human)	EC50	1.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
l 163191	Homo sapiens (human)	Activity	0.0003	1	1
ulimorelin	Homo sapiens (human)	DC50	0.0320	1	0
yil 781	Homo sapiens (human)	Kbapp	0.0110	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
growth hormone secretagogue receptor activity	molecular function	Combining with ghrelin to initiate a change in cell activity. [GOC:mah, PMID:17983853]
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
growth hormone-releasing hormone receptor activity	molecular function	Combining with growth hormone-releasing hormone to initiate a change in cell activity. [PMID:12529933]
peptide hormone binding	molecular function	Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]

Located In

This protein is located in 8 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
membrane raft	cellular component	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]
synaptic membrane	cellular component	A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:BHF, PMID:20410104]
Schaffer collateral - CA1 synapse	cellular component	A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689]
postsynapse	cellular component	The part of a synapse that is part of the post-synaptic cell. [GOC:dos]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 47 target(s):

Target	Category	Definition
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
spermatogenesis	biological process	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
learning or memory	biological process	The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125]
actin polymerization or depolymerization	biological process	Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. [GOC:mah]
adult feeding behavior	biological process	Feeding behavior in a fully developed and mature organism. [GOC:mah]
response to hormone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:jl]
hormone-mediated signaling pathway	biological process	The series of molecular signals mediated by the detection of a hormone. [GOC:sm]
negative regulation of norepinephrine secretion	biological process	Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. [GOC:dph, GOC:tb]
growth hormone secretion	biological process	The regulated release of growth hormone from secretory granules into the blood. [GOC:mah]
response to food	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. [GOC:add, ISBN:0721601464]
negative regulation of appetite	biological process	Any process that reduces appetite. [GOC:add]
positive regulation of appetite	biological process	Any process that increases appetite. [GOC:add]
response to follicle-stimulating hormone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]
response to estradiol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]
negative regulation of interleukin-1 beta production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]
negative regulation of interleukin-6 production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
negative regulation of tumor necrosis factor production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120]
cellular response to insulin stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
ghrelin secretion	biological process	The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone. [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin]
positive regulation of multicellular organism growth	biological process	Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. [GOC:dph, GOC:go_curators, GOC:tb]
regulation of hindgut contraction	biological process	Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. [GOC:jl, UBERON:0001046]
positive regulation of insulin-like growth factor receptor signaling pathway	biological process	Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]
positive regulation of fatty acid metabolic process	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]
negative regulation of insulin secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. [GOC:ai]
decidualization	biological process	The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. [ISBN:0721662544, PMID:11133685]
insulin-like growth factor receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
negative regulation of inflammatory response	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]
regulation of synapse assembly	biological process	Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]
regulation of transmission of nerve impulse	biological process	Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]
regulation of growth hormone secretion	biological process	Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. [GOC:dph]
response to growth hormone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. [GOC:BHF, GOC:dph]
cellular response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
response to dexamethasone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. [GOC:mah, GOC:yaf]
negative regulation of locomotion involved in locomotory behavior	biological process	Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. [GOC:dph, GOC:kmv, GOC:tb]
cellular response to thyroid hormone stimulus	biological process	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. [GOC:sjw, PMID:9916872]
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. [GOC:dos]
postsynaptic modulation of chemical synaptic transmission	biological process	Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. [GOC:dos]
regulation of postsynapse organization	biological process	Any process that modulates the physical form of a postsynapse. [GOC:ai, GOC:dph, GOC:tb]
positive regulation of small intestinal transit	biological process	Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine. [GOC:sl, PMID:15890336]
response to L-glutamate	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus. [GOC:TermGenie, PMID:23574009]
positive regulation of sprouting angiogenesis	biological process	Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958]
positive regulation of eating behavior	biological process	Any process that activates or increases the frequency, rate or extent of eating behavior. [GO_REF:0000058, GOC:TermGenie, PMID:11961051]
positive regulation of small intestine smooth muscle contraction	biological process	Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
regulation of gastric motility	biological process	Any process that modulates the frequency, rate or extent of gastric motility. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:9924029]
positive regulation of vascular endothelial cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
cellular response to insulin-like growth factor stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. [PMID:20042609]
negative regulation of macrophage apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]