aristolochic acid i has been researched along with Necrosis in 4 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The rats of Radix Aristolochice showed serious toxic responses of renal tubule atrophy and necrosis, meanwhile, the levels of BUN, Cr and NAG were increased obviously." | 1.34 | [Nephrotoxicity of Radix Aristolochice and it's substitution material Radix Inulae in rats]. ( Li, LD; Liu, YY; Qiao, HX; Wu, LM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shaohua, Z | 1 |
| Ananda, S | 1 |
| Ruxia, Y | 1 |
| Liang, R | 1 |
| Xiaorui, C | 1 |
| Liang, L | 1 |
| Li, Y | 1 |
| Liu, Z | 1 |
| Guo, X | 1 |
| Shu, J | 1 |
| Chen, Z | 1 |
| Li, L | 1 |
| Rossiello, MR | 1 |
| Laconi, E | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Sarma, DS | 1 |
| Qiao, HX | 1 |
| Liu, YY | 1 |
| Wu, LM | 1 |
| Li, LD | 1 |
4 other studies available for aristolochic acid i and Necrosis
| Article | Year |
|---|---|
Fatal renal failure due to the Chinese herb "GuanMu Tong" (Aristolochia manshuriensis): autopsy findings and review of literature.
Topics: Acute Kidney Injury; Adult; Aristolochia; Aristolochic Acids; Drugs, Chinese Herbal; Epithelial Cell | 2010 |
Aristolochic acid I-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro.
Topics: Animals; Apoptosis; Aristolochic Acids; Carcinogens; Cell Cycle; Cell Nucleus; Comet Assay; DNA Dama | 2006 |
Induction of hepatic nodules in the rat by aristolochic acid.
Topics: Animals; Aristolochic Acids; Carcinogens; Cell Division; Cocarcinogenesis; Hepatectomy; Liver; Liver | 1993 |
[Nephrotoxicity of Radix Aristolochice and it's substitution material Radix Inulae in rats].
Topics: Acetylglucosaminidase; Animals; Aristolochia; Blood Urea Nitrogen; Creatinine; Drugs, Chinese Herbal | 2007 |