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Dihydrofolate reductase
A protein that is a translation product of the folA gene in Staphylococcus aureus. [PRO:DNx, UniProtKB:P0A017]
Synonyms
DHFR;
EC 1.5.1.3
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.Cell chemical biology, , Dec-22, Volume: 23, Issue:12, 2016
Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.Journal of medicinal chemistry, , 07-14, Volume: 59, Issue:13, 2016
Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.ACS medicinal chemistry letters, , Jul-14, Volume: 7, Issue:7, 2016
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.Journal of medicinal chemistry, , Feb-13, Volume: 57, Issue:3, 2014
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:9, 2010
In vitro and in vivo properties of dihydrophthalazine antifolates, a novel family of antibacterial drugs.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:9, 2009
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase.Journal of medicinal chemistry, , Sep-06, Volume: 50, Issue:18, 2007
Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 13, Issue:23, 2003
Antifolate and antibacterial activities of 5-substituted 2,4-diaminoquinazolines.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.ACS medicinal chemistry letters, , Jul-14, Volume: 7, Issue:7, 2016
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.Journal of medicinal chemistry, , Feb-13, Volume: 57, Issue:3, 2014
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.Journal of medicinal chemistry, , Feb-13, Volume: 57, Issue:3, 2014
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:9, 2010
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 13, Issue:23, 2003