An ELAV-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15717]
| Target | Category | Definition |
|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| double-stranded RNA binding | molecular function | Binding to double-stranded RNA. [GOC:jl] |
| mRNA binding | molecular function | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234] |
| mRNA 3'-UTR binding | molecular function | Binding to a 3' untranslated region of an mRNA molecule. [GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| miRNA binding | molecular function | Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. [PMID:15066283] |
| mRNA 3'-UTR AU-rich region binding | molecular function | Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| lncRNA binding | molecular function | Binding to a long noncoding RNA (lncRNA). [PMID:25578728] |
| Target | Category | Definition |
|---|
| P-body | cellular component | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. [GOC:clt, PMID:12730603] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cytoplasmic stress granule | cellular component | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| sarcoplasm | cellular component | The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. [ISBN:0198547684] |
| cytoplasmic vesicle | cellular component | A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles] |
| postsynapse | cellular component | The part of a synapse that is part of the post-synaptic cell. [GOC:dos] |
| glutamatergic synapse | cellular component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
| Target | Category | Definition |
|---|
| protein import into nucleus | biological process | The directed movement of a protein from the cytoplasm to the nucleus. [GOC:jl] |
| post-transcriptional gene silencing | biological process | The inactivation of gene expression that occurs after transcription. [GOC:mah, PMID:15020054] |
| positive regulation of superoxide anion generation | biological process | Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell. [GOC:mah] |
| mRNA stabilization | biological process | Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules. [GOC:jid] |
| protein homooligomerization | biological process | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai] |
| negative regulation of miRNA-mediated gene silencing | biological process | A process that decreases the rate, frequency, or extent of gene silencing by a microRNA (miRNA). [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604] |
| mRNA destabilization | biological process | Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns. [GOC:dph, GOC:jh] |
| 3'-UTR-mediated mRNA stabilization | biological process | An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. [GOC:mah, PMID:19029303] |
| regulation of stem cell population maintenance | biological process | Any process that modulates the frequency, rate or extent of stem cell population maintenance. [GOC:obol] |