Proteins > Carboxylic ester hydrolase
Page last updated: 2024-08-07 17:27:13
Carboxylic ester hydrolase
[no definition available]
Synonyms
Research
Bioassay Publications (29)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 8 (27.59) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| naringenin | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| tacrine | Rattus norvegicus (Norway rat) | IC50 | 0.0995 | 9 | 9 |
| benextramine | Rattus norvegicus (Norway rat) | IC50 | 6.1659 | 1 | 1 |
| donepezil | Rattus norvegicus (Norway rat) | IC50 | 18.1114 | 12 | 12 |
| methoctramine | Rattus norvegicus (Norway rat) | IC50 | 0.9772 | 1 | 1 |
| donepezil hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 7.1380 | 1 | 1 |
| physostigmine | Rattus norvegicus (Norway rat) | IC50 | 0.0180 | 3 | 3 |
| bambuterol | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| rivastigmine | Rattus norvegicus (Norway rat) | IC50 | 7.3825 | 4 | 4 |
| huperzine a | Rattus norvegicus (Norway rat) | IC50 | 49.0767 | 3 | 3 |
| tacrine hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.0920 | 1 | 1 |
| apigenin | Rattus norvegicus (Norway rat) | IC50 | 275.0000 | 2 | 2 |
| genistein | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| huperzine b | Rattus norvegicus (Norway rat) | IC50 | 227.0000 | 1 | 1 |
| bis(7)-tacrine | Rattus norvegicus (Norway rat) | IC50 | 0.1675 | 5 | 5 |
| caproctamine | Rattus norvegicus (Norway rat) | IC50 | 11.7490 | 1 | 1 |
| xanthostigmine | Rattus norvegicus (Norway rat) | IC50 | 0.0480 | 1 | 1 |
| apremilast | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| histamine | Rattus norvegicus (Norway rat) | KA | 32.7000 | 2 | 2 |
| tacrine | Rattus norvegicus (Norway rat) | INH | 0.0810 | 1 | 1 |
| histidine methyl ester | Rattus norvegicus (Norway rat) | KA | 0.8950 | 2 | 2 |
Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.
Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice.
European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Pyridine alkaloids with activity in the central nervous system.
Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters, , Sep-20, Volume: 14, Issue:18, 2004
Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.
Journal of medicinal chemistry, , Mar-27, Volume: 46, Issue:7, 2003
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-16, Volume: 9, Issue:16, 1999
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Pyridine alkaloids with activity in the central nervous system.
Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters, , Sep-20, Volume: 14, Issue:18, 2004
Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.
Journal of medicinal chemistry, , Mar-27, Volume: 46, Issue:7, 2003
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-16, Volume: 9, Issue:16, 1999
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.
European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.
Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice.
European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Pyridine alkaloids with activity in the central nervous system.
Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.
Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice.
European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Pyridine alkaloids with activity in the central nervous system.
Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.
Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.
Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.
European journal of medicinal chemistry, , Oct-05, Volume: 240, 2022
European journal of medicinal chemistry, , Oct-05, Volume: 240, 2022
Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.
Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Pyridine alkaloids with activity in the central nervous system.
Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.
Journal of medicinal chemistry, , Feb-10, Volume: 48, Issue:3, 2005
Journal of medicinal chemistry, , Feb-10, Volume: 48, Issue:3, 2005
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors.
European journal of medicinal chemistry, , Volume: 63, 2013
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-16, Volume: 9, Issue:16, 1999
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors.
European journal of medicinal chemistry, , Volume: 63, 2013
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Bioorganic & medicinal chemistry letters, , Aug-16, Volume: 9, Issue:16, 1999
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.
Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.
Journal of medicinal chemistry, , Mar-26, Volume: 52, Issue:6, 2009
Journal of medicinal chemistry, , Mar-26, Volume: 52, Issue:6, 2009