A coagulation factor VII that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08709]
EC 3.4.21.21;
Proconvertin;
Serum prothrombin conversion accelerator;
SPCA
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 11 (68.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| niacinamide | Homo sapiens (human) | Ki | 8,000.0000 | 1 | 1 |
| benzamide | Homo sapiens (human) | Ki | 49,000.0000 | 2 | 2 |
| benzamidine | Homo sapiens (human) | Ki | 240.0000 | 1 | 1 |
| diazoxide | Homo sapiens (human) | IC50 | 740.0000 | 1 | 1 |
| isocarbostyril | Homo sapiens (human) | Ki | 19,000.0000 | 1 | 1 |
| dichlorobenzyl alcohol | Homo sapiens (human) | Ki | 13,000.0000 | 1 | 1 |
| mifepristone | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| 1-aminoisoquinoline | Homo sapiens (human) | Ki | 4,000.0000 | 1 | 1 |
| 5-chloroindole-2-carboxylate | Homo sapiens (human) | Ki | 3,500.0000 | 1 | 1 |
| 5-chloroindole | Homo sapiens (human) | Ki | 4,300.0000 | 1 | 1 |
| melagatran | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| razaxaban | Homo sapiens (human) | Ki | 6.9315 | 5 | 14 |
| trichostatin a | Homo sapiens (human) | IC50 | 0.0340 | 1 | 1 |
| arachidonic acid | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| palmitoleic acid | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| oleic acid | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| eicosapentaenoic acid | Homo sapiens (human) | IC50 | 78.0000 | 1 | 1 |
| linoleic acid | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| 8,11,14-eicosatrienoic acid | Homo sapiens (human) | IC50 | 52.5000 | 1 | 2 |
| gamma-linolenic acid | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| alpha-linolenic acid | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| ginkgolic acid | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| 11,14,17-eicosatrienoate | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| eicosa-11,14-dienoic acid, (z,z)-isomer | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| bms 740808 | Homo sapiens (human) | Ki | 2.8000 | 1 | 1 |
| dpc 423 | Homo sapiens (human) | Ki | 5.4744 | 2 | 7 |
| l-873724 | Homo sapiens (human) | IC50 | 0.0002 | 1 | 1 |
| anabaenopeptin b | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| dysinosin a | Homo sapiens (human) | Ki | 0.1090 | 2 | 2 |
| nn 414 | Homo sapiens (human) | IC50 | 696.0000 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| signaling receptor binding | molecular function | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| serine-type peptidase activity | molecular function | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| endoplasmic reticulum lumen | cellular component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
| Golgi lumen | cellular component | The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. [GOC:mah] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| vesicle | cellular component | Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles] |
| collagen-containing extracellular matrix | cellular component | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| serine-type peptidase complex | cellular component | A protein complex which is capable of serine-type peptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18640965] |
This protein is involved in 23 target(s):
| Target | Category | Definition |
|---|---|---|
| response to hypoxia | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd] |
| positive regulation of leukocyte chemotaxis | biological process | Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add] |
| blood coagulation | biological process | The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128] |
| circadian rhythm | biological process | Any biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:bf, GOC:go_curators] |
| response to carbon dioxide | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. [GOC:sm] |
| positive regulation of platelet-derived growth factor receptor signaling pathway | biological process | Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb] |
| protein processing | biological process | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg] |
| positive regulation of blood coagulation | biological process | Any process that activates or increases the frequency, rate or extent of blood coagulation. [GOC:mah] |
| positive regulation of cell migration | biological process | Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators] |
| animal organ regeneration | biological process | The regrowth of a lost or destroyed animal organ. [GOC:mah] |
| positive regulation of TOR signaling | biological process | Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah] |
| response to estradiol | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123] |
| response to vitamin K | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus. [GOC:sl] |
| response to genistein | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus. [GOC:mah] |
| response to estrogen | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:jl, ISBN:0198506732] |
| positive regulation of positive chemotaxis | biological process | Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai] |
| response to growth hormone | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. [GOC:BHF, GOC:dph] |
| response to cholesterol | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. [GOC:BHF, GOC:vk] |
| response to thyroxine | biological process | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. [GOC:sjw, PMID:9916872] |
| response to Thyroid stimulating hormone | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:11238928] |
| response to 2,3,7,8-tetrachlorodibenzodioxine | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670] |
| response to astaxanthin | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22309505] |
| response to thyrotropin-releasing hormone | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:21382270] |