quercetin

Research Excerpts

Overview

Quercetin (Que) is a flavonoid abundant in fruits and vegetables that exhibits anti-oxidant activity. It is a plant-derived metabolite belonging to the flavonoids class which presents a range of beneficial effects including anti-inflammatory, cardioprotective and anti-obesity. QuercetIn is a natural compound capable of antagonizing esophagus carcinoma.

Excerpt	Reference	Relevance
"Quercetin is a flavonoid natural product, that is, found in many foods and has been found to have a wide range of medicinal effects. "	( Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins. Chen, J; Hunt, CR; Taylor, JS; Wang, RE, 2011)	2.18
"Quercetin is a plant-derived flavonoid and its cytotoxic properties have been widely reported. "	( Delineation of the role of glycosylation in the cytotoxic properties of quercetin using novel assays in living vertebrates. Jung, DW; Kim, AR; Kim, HJ; Kim, KK; Park, SH; Shen, H; Shin, BA; Tyagi, N; Williams, DR; Yim, SH, 2014)	2.08
"Quercetin (Que) is a flavonoid abundant in fruits and vegetables that exhibits anti-oxidant activity."	( Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN/PI3K/AKT in grass carp hepatocytes. Miao, Z; Shi, X; Wang, S; Xu, S, 2021)	2.79
"Quercetin is a flavonoid with anti-oxidant, anti-cancer, anti-bacterial and anti-viral activities."	( Quercetin as an antiviral agent inhibits the Pseudorabies virus in vitro and in vivo. He, Q; Jiang, J; Li, C; Li, Z; Shangguan, A; Sun, Y; Zeng, W; Zhang, S, 2021)	2.79
"Quercetin (Que) is a natural compound capable of antagonizing esophagus carcinoma (EC)."	( Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis. Chen, X; Li, J; Wang, Y; Xia, C, 2022)	2.89
"Quercetin (QCT) is an effective antioxidant, antifibrotic and wound healing agent. "	( Quercetin loaded silver nanoparticles in hydrogel matrices for diabetic wound healing. Badhwar, R; Khanna, K; Mangla, B; Neupane, YR; Popli, H, 2021)	3.51
"Quercetin is a plant-derived metabolite belonging to the flavonoids class which presents a range of beneficial effects including anti-inflammatory, cardioprotective, anti-oxidant, anti-obesity, anti-carcinogenic, anti-atherosclerotic, anti-diabetic, anti-hypercholesterolemic, and anti-apoptotic activities."	( Quercetin and its role in modulating endoplasmic reticulum stress: A review. Eisvand, F; Seidel, V; Shakeri, A; Tabeshpour, J; Tajbakhsh, A; Zirak, MR, 2022)	2.89
"Quercetin is a flavonoid compound rich in many natural plants with a wide range of pharmacological effects and nutritional value. "	( Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2. Gong, M; Guan, Y; Li, B; Song, L; Wang, J; Wang, Y; Wu, X, 2021)	3.51
"Quercetin (Q) is a potent flavonol that has neuroprotective effects on AD derangements."	( Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer's disease rat model. Elfiky, AM; Elreedy, HA; Ghazy, MA; Ibrahim, KS; Mahmoud, AA, 2021)	2.79
"Quercetin (Que) is a promising flavonoid with broad-spectrum anti-tumor activity against various cancers, including MM; however, the underlying mechanism is not yet understood."	( Quercetin inhibits the proliferation of multiple myeloma cells by upregulating PTPRR expression. Cheng, T; Li, J; Li, L; Ma, R; Shi, J; Wang, H; Wang, Y; Wu, H; Yu, D; Zhai, H; Zhang, H, 2021)	2.79
"Quercetin is a natural flavonoid, which widely exists in nature, such as tea, coffee, apples, and onions. "	( A review on pharmacological activities and synergistic effect of quercetin with small molecule agents. Kamaraj, R; Pavek, P; Ye, H; Zhang, J; Zhang, T; Zou, H, 2021)	2.3
"Quercetin is a flavonoid found in a great variety of foods such as vegetables and fruits. "	( Morphological and mechanical changes induced by quercetin in human T24 bladder cancer cells. Adami, BS; de Oliveira, JR; Diz, FM; Dutra, AP; Morrone, FB; Oliveira Gonçalves, GP; Papaléo, RM; Reghelin, CK; Scherer, M; Wieck, A; Xavier, LL, 2021)	2.32
"Quercetin is a dietary flavonoid that can affect the balance between anti-oxidant defense system and oxidative stress. "	( The roles of quercetin in diabetes mellitus and related metabolic disorders; special focus on the modulation of gut microbiota: A comprehensive review. Askari, SF; Ayati, MH; Fazelian, S; Namazi, N; Roshanravan, N, 2023)	2.72
"Quercetin is a flavonoid with described antitumoral effect in different types of cancer cell lines that could be a possible option in GCTB treatment."	( Ultrastructural changes in giant cell tumor of bone cultured cells exposed to quercetin. Delgado-Cedillo, A; Estrada-Villaseñor, E; Hernández-Pérez, A; Hidalgo-Bravo, A; Landa Solís, C; Meneses, A; Olivos Meza, A; Santamaría, M, 2021)	1.57
"Quercetin is a naturally occurring phytochemical with good bioactivity, which mainly exists in the form of glycoside in vegetables, fruits, tea, and wine and exhibits beneficial health effects. "	( [Research progress on therapeutic potential of quercetin]. Feng, YL; Li, H; Liu, J; Ruan, Z; Zhai, GY, 2021)	2.32
"Quercetin is a flavonol that modifies many cellular processes. "	( Quercetin and HSC70 coregulate the anti-inflammatory action of the ubiquitin-like protein MNSFβ. Fukuma, Y; Kono, M; Nakamura, M; Notsu, K, 2022)	3.61
"Quercetin (QUE) is a flavonol reported with anti-inflammatory and antioxidant activities, and previous results from the group of this study have demonstrated its neuroprotective effect against lipopolysaccharide-induced neuropsychiatric injuries. "	( Protective effect of quercetin against the metabolic dysfunction of glucose and lipids and its associated learning and memory impairments in NAFLD rats. Chen, Z; Fang, K; Gao, XR; Ge, JF; Xu, JX, 2021)	2.38
"Quercetin is a polyphenolic molecule with a broad spectrum of biological activities derived from its antioxidant property. "	( Quercetin induces lipid domain-dependent permeability. Alvares, DS; Cabrera, MPDS; Leite, NB; Martins, DB, 2022)	3.61
"Quercetin is a flavonoid that is widely found in food species and has anti-inflammatory, antioxidant, and anticancer activities."	( Quercetin Prevents Radiation-Induced Oral Mucositis by Upregulating BMI-1. Dong, Q; Dong, X; Feng, Y; Hong, Y; Jiang, Z; Li, H; Liu, H; Liuyang, Z; Tao, J; Wang, G; Wang, Y; Xie, A; Zhang, J, 2021)	2.79
"Quercetin (Qct) is a flavonoid that belongs to the group of the most bioactive polyphenolic compounds. "	( Cardioprotective and nephroprotective effects of Quercetin against different toxic agents. Alasmari, AF, 2021)	2.32
"Quercetin is a flavonol compound that exerts a control effect on plant virus diseases, but its poor solubility and stability limit the control efficiency."	( Field application of nanoliposomes delivered quercetin by inhibiting specific hsp70 gene expression against plant virus disease. Hao, K; Shen, L; Su, C; Wang, F; Wang, J; Yang, J; Yu, F, 2022)	1.7
"Quercetin is a flavonoid in vegetables and fruits that has shown hepatoprotective potential, but little is known about its effects on HSCs activation."	( Effect of Quercetin on the fructose-activated human hepatic stellate cells, LX-2, an in-vitro study. Afarin, R; Akbari, R; Mohammadtaghvaei, N; Shakerian, E, 2022)	1.85
"Quercetin is a natural flavonoid that is known to have numerous pharmacological activities such as antioxidative, anti-inflammatory, and neuroprotective effects against various neurological disorders. "	( Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish. Kapil, L; Sahu, K; Singh, A; Singh, C; Singh, S, 2022)	3.61
"Quercetin is a bioactive flavonoid in O."	( Quercetin promotes cutaneous wound healing in mice through Wnt/β-catenin signaling pathway. Hu, P; Lu, S; Ma, X; Mi, Y; Pan, Y; Wei, Z; Yan, B; Yang, G; Zhong, L, 2022)	2.89
"Quercetin is a bioflavonoid compound with therapeutic benefits in metabolic diseases."	( Quercetin attenuates the proliferation, inflammation, and oxidative stress of high glucose-induced human mesangial cells by regulating the miR-485-5p/YAP1 pathway. Chen, S; Chen, X; Li, X; Pan, Q; Wan, H; Wang, Y; Yao, W, )	2.3
"Quercetin, a flavonoid, is an anti-oxidative, anti-allergic, antiviral, anti-inflammatory, and anticancer compound."	( Quercetin and Glioma: Which Signaling Pathways are Involved? Aschner, M; Barati, E; Mirzaei, H; Razavi, ZS; Razzaghi, N; Tamtaji, OR, 2022)	2.89
"Quercetin is a polyphenol found in plant and has neuroprotective effects against neurodegenerative diseases."	( Quercetin ameliorates glutamate toxicity-induced neuronal cell death by controlling calcium-binding protein parvalbumin. Kang, JB; Koh, PO; Park, DJ; Shah, MA, 2022)	2.89
"Quercetin is a pharmacologically active polyphenol found in quinoa."	( Quinoa Soluble Fiber and Quercetin Alter the Composition of the Gut Microbiome and Improve Brush Border Membrane Morphology In Vivo ( Agarwal, N; Even, C; Khen, N; Kolba, N; Koren, O; Tako, E; Turjeman, S, 2022)	1.75
"Quercetin is a plant-derived polyphenol flavonoid that has been proven to be effective for many diseases. "	( The potential biological effects of quercetin based on pharmacokinetics and multi-targeted mechanism Amuti, S; Chen, D; Fu, J; Han, P; Jiang, JD; Keranmu, A; Liu, YF; Ma, SR; Pan, LB; Wang, MS; Wang, Y; Xing, NZ; Xu, H; Yang, FY; Yu, H; Zhang, ZW, 2022)	2.44
"Quercetin is a polyphenolic flavonoid plant secondary metabolite with a well-characterized antioxidant activity."	( A Comprehensive View on the Quercetin Impact on Colorectal Cancer. Alaya, A; Maghiar, AM; Maghiar, TA; Mathe, E; Neamtu, AA; Neamtu, C; Olah, NK; Pelea, D; Totolici, BD; Turcus, V, 2022)	1.74
"Quercetin is a flavonoid abundantly present in plant-based foods, with a possible impact on cardiovascular health."	( Quercetin Mitigates Endothelial Activation in a Novel Intestinal-Endothelial-Monocyte/Macrophage Coculture Setup. Boon, N; De Munck, J; Grootaert, C; Raes, K; Smagghe, G; Van Camp, J; Vissenaekens, H, 2022)	2.89
"Quercetin is a natural flavonoid present in many vegetables and fruits and has immunomodulatory, anti-inflammatory, and antioxidant properties."	( Quercetin-Ameliorated, Multi-Walled Carbon Nanotubes-Induced Immunotoxic, Inflammatory, and Oxidative Effects in Mice. Abou El-Fotoh, MF; Ahmed, MM; Alshahrani, MY; El-Magd, MA; Ghamry, HI; Magdy, A; Sallam, AA, 2022)	2.89
"Quercetin is a natural product with antioxidative, anti-inflammatory, and antiproliferative properties."	( Quercetin attenuates the proliferation of arsenic-related lung cancer cells via a caspase-dependent DNA damage signaling. Li, X; Wen, Q; Yang, P; Zhao, X, 2022)	2.89
"Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals."	( Health Benefits of Quercetin in Age-Related Diseases. Maurya, PK, 2022)	1.77
"Quercetin (Quer) is a natural polyphenolic compound widely used in traditional Chinese medicine."	( Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav-1 signaling. Chen, B; Chen, J; Yang, Y; Zhang, H, 2022)	2.89
"Quercetin is a flavonoid present in the human diet with multiple health benefits. "	( Structural, dynamic, and hydration properties of quercetin and its aggregates in solution. Campo, MG; Corral, GM, 2022)	2.42
"Quercetin is a potent anti-oxidative bioflavonoid."	( Quercetin ameliorates oxidative stress‑induced cell apoptosis of seminal vesicles via activating Nrf2 in type 1 diabetic rats. Chen, J; Chen, ZS; Dong, B; Dong, Y; Han, C; Shi, Z; Wu, W; Wu, ZX, 2022)	2.89
"Quercetin is a phytochemical that has strong antioxidant properties and pro-apoptotic effects and has been investigated for many years."	( Senescence-mediated anticancer effects of quercetin. Becer, E; Özsoy Gökbilen, S; Vatansever, HS, 2022)	1.71
"Quercetin is a flavonol compound that can be found in dietary fruits and vegetables."	( Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway. Chang, YC; Cheng, HC; Chou, WC; Huang, YT; Ou, HC; Tsai, KL; Wang, SH, 2022)	2.89
"Quercetin is a natural flavonoid exhibiting antiviral activity against CMV by a mechanism distinct from GCV, but is poorly soluble, limiting its use as a therapeutic."	( Poloxamer 188 - quercetin formulations amplify in vitro ganciclovir antiviral activity against cytomegalovirus. Britt, DW; Kjar, A; Vargis, E; Wadsworth, I, 2022)	1.79
"Quercetin is a flavonoid that is widely found in fruits and vegetables. "	( Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs. Itou, H; Takeda, M; Toyota, R, 2022)	2.52
"Quercetin is a potent, naturally occurring GLP-1 secretagogue."	( Novel luciferase-based glucagon-like peptide 1 reporter assay reveals naturally occurring secretagogues. Alexandru, PR; Anghel, SA; Badea, RA; Chiritoiu, G; Patriche, DS; Pena, F, 2022)	1.44
"Quercetin is a flavonoid with a wide range of pharmacological activities, including anticancer, antioxidant, and anti-inflammatory effects. "	( Quercetin Reduces the Development of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Cleft Palate in Mice by Suppressing CYP1A1 via the Aryl Hydrocarbon Receptor. Ishii, T; Morikawa, T; Nishii, Y; Sakamoto, T; Satake, K, 2022)	3.61
"Quercetin is a kind of flavonoid with important bioactivities, such as hypoglycemic, antioxidant, anti-inflammatory, and anti-allergic properties. "	( Anti-Allergic Effects of Quercetin and Quercetin Liposomes in RBL-2H3 Cells. Guan, R; Huang, H; Zhang, Y, 2023)	2.66
"Quercetin (QUE) is a natural flavonoid that is ubiquitous in fruits and vegetables."	( Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis. Ji, B; Li, F; Peng, W; Tang, M; Xie, X; Yang, Y; Zeng, Y, 2022)	1.72
"Quercetin (QUR) is a natural compound of flavonoids found in a variety of foods and medicinal plants."	( Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review. Chen, T; Jia, F; Liu, X; Wang, C; Yu, Y; Zhang, N; Zhang, W; Zhu, S, 2022)	1.78
"Quercetin is a polyphenolic bioactive compound highly enriched in dietary fruits, vegetables, nuts, and berries. "	( Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies. Kumar, V; Prakash, C; Rabidas, SS; Sharma, D; Tyagi, J, 2023)	2.66
"Quercetin is a privileged molecule that is known to interfere at different levels of inflammatory response."	( Quercetin against Emerging RNA Viral Diseases: Potential and Challenges for Translation. Subudhi, BB; Swain, RP, 2023)	3.07
"Quercetin (QT) is an effective apoptosis inhibitor and antioxidant flavonoid, but its water solubility is poor and has no targeting."	( A Water-Soluble Quercetin Conjugate with Triple Targeting Exerts Neuron-Protective Effect on Cerebral Ischemia by Mitophagy Activation. Cen, J; Cui, J; Duan, S; Guo, Y; Zhang, C; Zhang, R; Zhang, X; Zhao, K; Zhao, T, 2022)	1.79
"Quercetin (QUE) is a well-known natural product that can exert beneficial properties on human health. "	( Comparative Interaction Studies of Quercetin with 2-Hydroxyl-propyl-β-cyclodextrin and 2,6-Methylated-β-cyclodextrin. Cournia, Z; Diamantis, DA; Georgiou, N; Javornik, U; Mauromoustakos, T; Papadourakis, M; Papakyriakopoulou, P; Plavec, J; Tzakos, AG; Tzeli, D; Vakali, V; Valsami, G; Zoupanou, N, 2022)	2.44
"Quercetin (QT) is a flavonoid that exhibits anti-oxidant and chemo-preventive activity. "	( Development of surface modified bilosomes for the oral delivery of quercetin: optimization, characterization in-vitro antioxidant, antimicrobial, and cytotoxicity study. Alnomasy, SF; Alomar, FA; Alquraini, A; Alruwaili, NK; Alsaidan, OA; Mostafa, EM; Rawaf, A; Yasir, M; Zafar, A, 2022)	2.4
"Quercetin is a flavonoid widely found in numerous vegetables, fruits, and foods and is thought to have antioxidant and anti-inflammatory properties, which may be associated with improvement of chemotherapy sensitivity during pancreatic cancer treatment."	( Quercetin improves pancreatic cancer chemo-sensitivity by regulating oxidative-inflammatory networks. Hu, Y; Jin, J; Li, R; Ma, R; Wang, Y, 2022)	2.89
"Quercetin (Qu) is a bioflavonoid with striking biological activities."	( Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities. Al Sberi, H; Albrakati, A; Alharthi, F; Alhazmi, A; Alsharif, KF; Althagafi, HA; Elhefny, MA; Gewaily, MS; Habotta, OA; Hassan, AA; Hawsawi, YM; Kassab, RB; Khafaga, AF; Lokman, MS; Mufti, AH; Theyab, A, 2023)	1.95
"Quercetin is a widely distributed, bioactive flavonoid compound, which displays potential to inhibit fibrosis in several diseases. "	( Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy. Jiang, D; Li, X; Ma, Z; Wang, F; Wang, Q, 2023)	3.8
"Quercetin is an organic flavonoid present in several fruits and vegetables. "	( Sub-chronic oral toxicity screening of quercetin in mice. Aladhami, A; Chatzistamou, I; Cunningham, P; Enos, RT; Fan, D; Madero, S; Murphy, EA; Patton, E; Unger, C; VanderVeen, BN; Velázquez, KT, 2022)	2.43
"Quercetin is a flavonol ubiquitously present in fruits and vegetables that shows a potential therapeutic use in non-transmissible chronic diseases, such as cancer and diabetes. "	( Cytotoxicity of quercetin is related to mitochondrial respiration impairment in Saccharomyces cerevisiae. Arvizu-Medrano, SM; Canizal-Garcia, M; Carrillo-Garmendia, A; González-Hernández, JC; Gracida, J; Madrigal-Perez, LA; Martinez-Ortiz, C; Regalado-Gonzalez, C, 2022)	2.51
"Quercetin (Que) is a natural bioflavonoid compound with anti-inflammatory and antioxidative properties that reportedly inhibits the NLRP3 inflammasome in sepsis-induced organ dysfunctions such as ALI."	( Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation. Chen, LL; Dai, MH; Han, DD; Li, W; Li, Y; Lin, FY; Pan, PH; Song, C; Zhang, Y; Zhao, YH, 2022)	2.89
"Quercetin is a flavonol-type antioxidant that may be found in many foods."	( Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial. Amidi, F; Amini, N; Moini, A; Parivr, K; Rudbari, NH; Vaez, S, 2023)	3.07
"Quercetin (Qu) is a dietary antioxidant and a member of flavonoids in the plant polyphenol family. "	( Anti-Inflammatory, Antioxidative, and Nitric Oxide-Scavenging Activities of a Quercetin Nanosuspension with Polyethylene Glycol in LPS-Induced RAW 264.7 Macrophages. Do, GS; Kang, SG; Kwon, JB; Lee, GB; Oh, SY; Singh, M; Vinayagam, R; Yang, SJ, 2022)	2.39
"Quercetin is a naturally occurring bioactive flavonoid abundant in many plants and fruits. "	( Neuropharmacological interventions of quercetin and its derivatives in neurological and psychological disorders. Agrawal, K; Arfin, S; Chakraborty, P; Das, SS; Dewanjee, S; Dey, A; Jafari, SM; Jha, NK; Jha, SK; Kumar, D; Mishra, PC; Moustafa, M, 2023)	2.62
"Quercetin is a natural polyphenol, considered as nutraceutical agent which produce antioxidant effects."	( Quercetin impact against psychological disturbances induced by fat rich diet. Arshad, M; Farhan, M; Rafi, H; Rafiq, H; Rehman, S, 2022)	2.89
"Quercetin is a natural polyphenol, which protects neurodegeneration, remarkably by suppressing oxidative stress and inflammation."	( Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1. Bayazid, AB; Lim, BO, 2022)	2.89
"Quercetin is a flavonoid that reduces MMP-2 activity and ameliorates hypertrophic vascular remodeling of hypertension."	( Quercetin decreases cardiac hypertrophic mediators and maladaptive coronary arterial remodeling in renovascular hypertensive rats without improving cardiac function. Bertozi, G; Castro, MM; da Rocha, EV; de Mello, MMB; Falchetti, F; Gomes, BQ; Nogueira, RC; Parente, JM; Pernomian, L; Sanches-Lopes, JM; Tanus-Santos, JE, 2023)	3.07
"Quercetin (QT) is a multipurposed drug with reported bone-conserving properties."	( Development and evaluation of local regenerative biomimetic bone-extracellular matrix scaffold loaded with nano-formulated quercetin for orthopedic fractures. Abdallah, OY; Ali, MM; Aly, RG; Heikal, LA; Kamal, NH, 2023)	1.84
"Quercetin (Que) is a potent anti-inflammatory and antioxidant flavonoid with cardioprotective potential. "	( Quercetin alleviates diastolic dysfunction and suppresses adverse pro-hypertrophic signaling in diabetic rats. Bartekova, M; Bartosova, L; Duris-Adameova, A; Ferenczyova, K; Galis, P; Horvath, C; Kalocayova, B; Rajtik, T; Szobi, A, 2022)	3.61
"Quercetin (QCT) is a naturally occurring phenolic flavonoid compound with inbuilt characteristics of antioxidant, anti-inflammatory, and immune protection. "	( Protective role of engineered extracellular vesicles loaded quercetin nanoparticles as anti-viral therapy against SARS-CoV-2 infection: A prospective review. Agarwal, S; Giri, R; Jeong, GB; Kala, S; Raghav, A, 2022)	2.41
"Quercetin is a natural flavonoid that exhibits anti-inflammatory and antioxidant properties, and its antioxidant activity is correlated with POI."	( Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells. Chen, B; Chen, Y; Miao, C; Wang, R; Yang, L; Zhang, Q; Zhao, Y, 2022)	2.89
"Quercetin is a popular flavonoid with lower adverse effects and has anti-tumor properties."	( Quercetin Effects on Cell Cycle Arrest and Apoptosis and Doxorubicin Activity in T47D Cancer Stem Cells. Atashpour, S; Azizi, E; Barzegar, E; Fouladdel, S; Ghahremani, MH; Komeili Movahhed, T; Modaresi, F; Ostad, SN, 2022)	2.89
"Quercetin is a key ingredient of anti-HCC activity in Xihuang Pills by regulating macrophage polarization and promoting autophagy via the NF-κB pathway."	( Quercetin, the Ingredient of Xihuang Pills, Inhibits Hepatocellular Carcinoma by Regulating Autophagy and Macrophage Polarization. Chen, J; Tian, S; Tian, X; Wang, Y; Wu, R; Xiong, J; Zhang, Z; Zhou, T, 2022)	3.61
"Quercetin is a kind of polyphenolic flavonoid compounds which has perfect antioxidant properties. "	( Synthesis of Quercetin-Acid Esters and Its Reduction of H Hui, AL; Li, JW; Li, SN; Lin, YT; Liu, H; Liu, QS; Wang, YC; Wu, ZY; Zhang, WC, 2023)	2.72
"Quercetin is a natural flavonoid, can be present in natural foods and plants."	( Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway. El-Shaer, NO; Hegazy, AM; Muhammad, MH, 2023)	1.95
"Quercetin is a natural flavonoid found in common food species, with the characteristics of antioxidative, anti-inflammatory, and anti-cancerous activity."	( Quercetin Mitigates Radiation-Induced Intestinal Injury and Promotes Intestinal Regeneration via Nrf2-Mediated Antioxidant Pathway1. Li, J; Li, Y; Liu, Y; Wu, L; Xu, Y; Yang, M; Yu, Z; Yue, L; Zhang, B; Zhang, Y; Zhou, X; Zhu, X, 2023)	3.07
"Quercetin is a natural flavonoid compound found in many kinds of plants and foods."	( Quercetin Induces Cell Cycle Arrest and Apoptosis in YD10B and YD38 Oral Squamous Cell Carcinoma Cells. Kim, D; Son, HK, 2023)	3.07
"Quercetin is a flavonoid with anti-inflammatory and antioxidant properties as well as neuroprotective effects."	( Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress. Amini-Khoei, H; Korani, MS; Lorigooini, Z; Rahimi-Madiseh, M; Tahmasebi Dehkordi, H; Tavakoli, Z, 2023)	1.93
"Quercetin is a flavonoid that can be found in a variety of foods, including fruits and vegetables."	( Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions. Chowdhury, MAH; Hossain, KH; Nisa, FY; Rahman, MA; Saha, S; Shorobi, FM; Srisuphanunt, M, 2023)	3.07
"Quercetin is a cheap and easily accessible therapeutic option for COVID-19 patients."	( Quercetin for the treatment of COVID-19 patients: A systematic review and meta-analysis. Awan, RU; Cheema, HA; Chinnam, S; Fatima, A; Nashwan, AJ; Shahid, A; Shahzil, M; Sohail, A; Ur Rehman, ME, 2023)	3.07
"Quercetin is a flavonoid with various cytoprotective effects. "	( Decrease in cholesterol in the cell membrane is essential for Nrf2 activation by quercetin. Hashimoto, N; Kawabe, T; Kusatsugu, Y; Matsushima, M; Nose, H; Ohdachi, T; Sato, M; Takekoshi, M; Taniguchi, H; Tsuzuki, H, 2023)	2.58
"Quercetin is a naturally sourced flavonoid with anti-inflammatory and antioxidant activities."	( Quercetin Reprograms Immunometabolism of Macrophages via the SIRT1/PGC-1α Signaling Pathway to Ameliorate Lipopolysaccharide-Induced Oxidative Damage. Cui, D; Hao, B; He, J; Li, H; Liu, Y; Lv, Y; Peng, J; Pu, W; Shang, R; Wang, S; Wang, X; Yang, Z; Zhang, H, 2023)	3.07
"Quercetin is a polyphenol flavonoid compound from natural plants with anti-inflammatory and antioxidant functions."	( Quercetin alleviates gliotoxin-induced duckling tissue injury by inhibiting oxidative stress, inflammation and increasing heterophil extracellular traps release. Chen, M; Gao, X; Hong, H; Jiang, L; Jiang, Y; Jin, Q; Jin, Z; Liu, Q; Liu, W; Qian, Y; Wei, Z; Xu, J, 2023)	3.07
"Quercetin is a bioflavonoid with antioxidant, anti-inflammatory, anti-aging and anti-cancer properties."	( Protective Effects of Querectin against MPP Alimujiang, A; Huang, D; Jiang, Y; Xie, G; Xie, H; Yang, W; Yin, F, 2023)	1.63
"Quercetin is a naturally existing plant pigment belonging to the flavonoid group; it is contained in a wide range of vegetables and fruits. "	( Quercetin as a Dietary Supplementary Flavonoid Alleviates the Oxidative Stress Induced by Lead Toxicity in Male Wistar Rats. Abd-Elwahab, MM; Al-Doaiss, AA; Al-Eissa, MS; Al-Zharani, M; Mubarak, M; Rudayni, HA, 2023)	3.8
"Quercetin is a well-known plant flavanol that exhibits multiple biological activities, including antioxidant, anti-inflammatory and anticancer activities. "	( The significance of quercetin-loaded advanced nanoformulations for the management of diabetic wounds. Chaudhary, A; Imran, M; Mohammed, Y; Panthi, VK; Paudel, KR, 2023)	2.68
"Quercetin (QT) is a very effective anticancer drug in combating breast cancer. "	( Delivery of quercetin for breast cancer and targeting potentiation via hyaluronic nano-micelles. Li, M; Lin, K; Liu, Z; Sun, J; Wang, W; Wang, Z; Zhang, S; Zhao, Y; Zhen, Y, 2023)	2.73
"Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. "	( The therapeutic potential of quercetin for cigarette smoking-induced chronic obstructive pulmonary disease: a narrative review. Chen, J; Ding, K; Jia, H; Jiang, W; Lei, M; Wang, Y; Xiong, C; Zhan, W, )	1.87
"Quercetin is a plant flavonoid with a molecular formula C"	( Dietary quercetin protects Cherax quadricarinatus against white spot syndrome virus infection. Gong, J; Pan, X; Zhou, X; Zhu, F, 2023)	2.79
"Quercetin is a plant flavonoid, mostly used as a constituent in dietary products."	( Quercetin abrogates lipopolysaccharide-induced depressive-like symptoms by inhibiting neuroinflammation via microglial NLRP3/NFκB/iNOS signaling pathway. Abubakar, B; Adeniyi, FR; Adeoluwa, GO; Adeoluwa, OA; Akinluyi, ET; Edem, EE; Eduviere, AT; Fafure, A; Nebo, K; Olayinka, JN, 2023)	3.07
"Quercetin is an essential flavonoid mostly found in herbal plants, fruits, and vegetables, which exhibits anti-hypertension properties. "	( Quercetin attenuates angiotensin II-induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo. Ali, F; Cheng, Y; Chu, J; Peng, J; Saleem, MZ; Shen, A; Wang, D; Wei, L; Wu, M; Xie, Y; Yan, M; Yang, Y, )	3.02
"Quercetin (Que) is a hydrophobic flavanol that has the potential to prevent colon diseases. "	( Preparation of core-shell hordein/pectin nanoparticles as quercetin delivery matrices: Physicochemical properties and colon-specific release analyses. Luo, T; Sun, Y; Wei, Z; Xue, C; Zhang, X, 2023)	2.6
"Quercetin (QT) is a natural dietary flavonoid with good safety and multifaceted pharmacological activities against inflammation."	( Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease. Chen, H; Fang, Y; Huang, Y; Jing, S; Liu, E; Muhitdinov, B; Shen, H; Zeng, F; Zhang, M, 2023)	1.86
"Quercetin is a flavonol widely distributed in plants and has various described biological functions. "	( Dopaminergic modulation by quercetin: In silico and in vivo evidence using Caenorhabditis elegans as a model. Aschner, M; Ávila, DS; Carrazoni, T; Dal Belo, CA; Martins, CF; Mori, MA; Müller, RU; Paula, FR; Rios-Anjos, RM; Salgueiro, WG; Soares, MV, 2023)	2.65
"Quercetin (QUE) is a plant polyphenol with anti-inflammatory and antioxidant properties."	( Quercetin Alleviates Deoxynivalenol-Induced Intestinal Damage by Suppressing Inflammation and Ferroptosis in Mice. Chen, Y; Fu, Y; Hong, X; Jiang, M; Sun, Y; Wang, J; Wang, X; Wu, H; Yang, Z; Ye, Y; Zhou, E, 2023)	3.07
"Quercetin (Qu) is a powerful flavanol antioxidant that is naturally found in plants and is part of the flavonoid family. "	( Neuroprotective effect of quercetin and nano-quercetin against cyclophosphamide-induced oxidative stress in the rat brain: Role of Nrf2/ HO-1/Keap-1 signaling pathway. Abass, HI; AbdElrazek, DA; Farroh, KY; Hassan, NH; Hassanen, EI; Ibrahim, MA, 2023)	2.65
"Quercetin is a natural flavonoid widely found in natural fruits and vegetables. "	( Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury. Gu, J; Lu, G; Tang, Y; Zhang, X, 2023)	2.62
"Quercetin is a flavonoid compound, which has anti-inflammatory and antioxidant roles."	( Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice. Ge, C; Lei, L; Wang, S; Wu, X, 2023)	3.07
"Quercetin (QUE) is a natural polyphenol known to have numerous pharmacological properties against infectious and non-infectious diseases. "	( Quercetin inhibits Toxoplasma gondii tachyzoite proliferation and acts synergically with azithromycin. Abugri, DA; Ayariga, JA; Napier, A; Robertson, BK; Sharma, HN; Wijerathne, SVT, 2023)	3.8
"Quercetin (Que) is a natural compound that has demonstrated chemopreventive effects against different types of tumors."	( Potential Therapeutic Targets of Quercetin in the Cutaneous Melanoma Model and Its Cellular Regulation Pathways: A Systematic Review. Fernandes E Silva, E; Lopes, AC; Nascimento, MAD; Paiva, LS; Salgado, MTSF; Votto, APS, 2023)	1.91
"Quercetin (QUER) is a natural polyphenolic compound endowed with beneficial properties for human health, with anti-aging effects. "	( Sir2 and Glycerol Underlie the Pro-Longevity Effect of Quercetin during Yeast Chronological Aging. Abbiati, F; Garagnani, SA; Orlandi, I; Vai, M, 2023)	2.6
"Quercetin (QT) is a dietary flavonoid known for its anti-inflammatory effects and safe use in humans."	( Cyclodextrin-Coordinated Liposome-in-Gel for Transcutaneous Quercetin Delivery for Psoriasis Treatment. Chen, R; Gao, N; Gong, S; Huang, Y; Liu, E; Liu, L; Pan, L; Shen, H; Zhang, Y, 2023)	1.87
"Quercetin is a vital flavonoid widely occurring in fruits and vegetables and has received significant interest as a prospective anti-inflammatory antioxidant."	( Quercetin Alleviates Lipopolysaccharide-Induced Cell Oxidative Stress and Inflammatory Responses via Regulation of the TLR4-NF-κB Signaling Pathway in Bovine Rumen Epithelial Cells. Huang, Y; Jiang, M; Wang, K; Yang, T; Zhan, K; Zhang, X; Zhao, G, 2023)	3.07
"Quercetin is a bioactive flavonoid, but the effect of it on cardiometabolic factors has remained uncertain and previous findings from meta-analyses have been controversial."	( The effects of Quercetin supplementation on cardiometabolic outcomes: An umbrella review of meta-analyses of randomized controlled trials. Arabi, SM; Bahrami, LS; Chambari, M; Maleki, M; Sahebkar, A; Shahraki Jazinaki, M; Sukhorukov, VN, 2023)	2.71
"Quercetin is an important source of free radical scavengers."	( Investigation of the combined cytotoxicity induced by sodium butyrate and a flavonoid quercetin treatment on MCF-7 breast cancer cells. Aksoy, O; Alimudin, J; Aydin, D; Betts, Z; Deveci Ozkan, A; Yanar, S; Yuksel, B, 2023)	1.85
"Quercetin is a naturally occurring flavonoid, with numerous pharmaceutical activities like anti-oxidant, anti-inflammatory, and anti-tumor effects."	( Anti-Inflammatory and Antioxidant Activity of Titanium Dioxide Nanotubes Conjugated with Quercetin. Gulla, S; Lomada, D; Reddy, MC, 2023)	1.85
"Quercetin (QC) is a naturally occurring flavonoid found in abundance in fruits and vegetables. "	( Quercetin-loaded solid lipid nanoparticles exhibit antitumor activity and suppress the proliferation of triple-negative MDA-MB 231 breast cancer cells: implications for invasive breast cancer treatment. Hatami, M; Kheirollah, A; Khorsandi, L; Kouchak, M; Rashidi, M, 2023)	3.8
"Quercetin (Que) is a flavonol compound found in plants, which has a variety of biological activities. "	( Quercetin Ameliorates Deoxynivalenol-Induced Intestinal Injury and Barrier Dysfunction Associated with Inhibiting Necroptosis Signaling Pathway in Weaned Pigs. Chen, S; Guo, J; Liu, J; Liu, Y; Lv, Q; Qin, X; Xiao, K; Xu, Q; Xu, X; Zhao, J; Zhou, M, 2023)	3.8
"Quercetin is a flavonol belonging to the flavonoid group of polyphenols. "	( Quercetin induces pathogen resistance through the increase of salicylic acid biosynthesis in An, J; Bahk, S; Chung, WS; Hong, JC; Kim, SH; Le Anh Pham, M; Lee, J; Park, J; Ramadany, Z, 2023)	3.8
"The quercetin acts as an enzyme inducer by renewing the glutathione peroxidase activity and inhibiting the oxidation of proteins and hence decreases the oxidative stress. "	( Extraction and Identification of Two Flavonoids in Phlomoides hyoscyamoides as an Endemic Plant of Iran: The Role of Quercetin in the Activation of the Glutathione Peroxidase, the Improvement of the Hydroxyproline and Protein Oxidation in Bile Duct-Ligate Doustimotlagh, AH; Eftekhari, M; Mansourian, M; Taheri, S, 2020)	1.33
"Quercetin is a bioflavonoid with well-known antidiabetic and antifibrotic properties."	( Quercetin Mitigates Hepatic Insulin Resistance in Rats with Bile Duct Ligation Through Modulation of the STAT3/SOCS3/IRS1 Signaling Pathway. Eshaghian, A; Khodarahmi, A; Moradi, A; Safari, F, 2019)	2.68
"Quercetin is a widely used bioflavonoid found in onions, grapes, berries and citrus fruits. "	( Quercetin-induced inactivation and conformational alterations of alpha-2-macroglobulin: multi-spectroscopic and calorimetric study. Ahsan, H; Khan, FH; Siddiqui, T; Zia, MK, 2020)	3.44
"Quercetin is a hydrophobic flavonoid with high antioxidant activity. "	( Preparation and Characterization of Quercetin-Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability. Barreras-Urbina, CG; Carvajal-Millan, E; Castro-Enríquez, DD; Del-Toro-Sánchez, CL; Javier Cinco-Moroyoqui, F; Juárez, J; López-Ahumada, GA; Rodríguez-Félix, F; Ruiz-Cruz, S; Tapia-Hernández, JA, 2019)	2.23
"Quercetin is a plant-derived chemical belonging to the family of flavonoids."	( Autophagy as a molecular target of quercetin underlying its protective effects in human diseases. Ahmadi, Z; Ashrafizadeh, M; Farkhondeh, T; Samarghandian, S, 2022)	1.72
"Quercetin is a flavonoid extract of Ginkgo biloba leaves."	( Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology. Chen, C; Mao, W; Wu, XJ; Zhou, XB, 2019)	1.53
"Quercetin is a natural flavonoid with important biological properties (anti-inflammatory, antihistamine and anti-oxidative actions)."	( Supplementary prevention and management of asthma with quercetin phytosome: a pilot registry. Belcaro, G; Cesarone, MR; Cotellese, R; Dugall, M; Feragalli, B; Hosoi, M; Hu, S; Ledda, A; Maione, C, 2019)	1.48
"Quercetin is a flavonoid that is abundant in apples, grapes, red raspberry, and onions and has been reported to inhibit RAGE."	( Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells. Chen, SY; Kuo, CW; Lan, CY; Lu, CC; Yen, GC, 2019)	2.68
"Quercetin is a plant flavonoid with great potential for the prevention and treatment of disease. "	( Quercetin-Amino Acid Conjugates are Promising Anti-Cancer Agents in Drug Discovery Projects. Atamaniuk, VP; Dobrydnev, AV; Popova, MV; Tkachuk, TM, 2020)	3.44
"Quercetin is a bioactive flavonoid and has been shown to protect against HCC through its antioxidant activity."	( Beyond its antioxidant properties: Quercetin targets multiple signalling pathways in hepatocellular carcinoma in rats. Abdel-Rahman, N; El Gayyar, AM; El-Karef, A; Salama, YA, 2019)	1.51
"Quercetin is a flavonol polyphenol widely found in many vegetables, grains, and fruits. "	( Quercetin depletes intracellular Ca Chan, P; Chen, CY; Hour, MJ; Leung, YM; Shiao, LR; So, EC; Wong, KL, 2020)	3.44
"Quercetin is a flavonoid and is abundant in the plant kingdom. "	( Green Synthetic Nanoarchitectonics of Gold and Silver Nanoparticles Prepared Using Quercetin and Their Cytotoxicity and Catalytic Applications. Lee, YJ; Park, Y, 2020)	2.23
"Quercetin is a naturally occurring polyphenol present in various fruits and vegetables. "	( Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. Byun, S; Hong, S; Lee, JS; Lim, TG; Shin, EJ, 2019)	3.4
"Quercetin is a type of flavonoid compound that influences antioxidant and anti-inflammatory activities have protective and therapeutic effects for treating various diseases including diabetes mellitus and neuro-degenerative diseases."	( The protective effect of quercetin in the alcohol-induced liver and lymphoid tissue injuries in newborns. Ince, E, 2020)	1.58
"Quercetin is a flavonoid that presents several biological activities, including anti-hRSV role."	( Quercetin pentaacetate inhibits in vitro human respiratory syncytial virus adhesion. Caruso, IP; da Costa, MF; da Silva, TF; de Araujo, GC; de Oliveira, J; de Souza, FP; Desideri, A; Falconi, M; Genova Ribeiro, A; Iacovelli, F; Kubo, LH; Lima, CS; Lopes, BRP; Regasini, LO; Toledo, KA, 2020)	2.72
"Quercetin is a kind of flavonoid compounds that comes from nature and is widely existed in the daily diet. "	( Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Deng, XT; Ge, XX; Li, QP; Miao, L; Tang, SM; Zhou, J, 2020)	2.27
"Quercetin is a flavonoid present in fruits, vegetables and plants with antioxidant, anti-inflammatory and anticancer properties. "	( Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review. Fernández-Palanca, P; Fondevila, F; González-Gallego, J; Mauriz, JL; Méndez-Blanco, C; Tuñón, MJ, 2019)	2.28
"Quercetin is a flavonoid that exhibits potential pharmacological activity on mental diseases."	( Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation. Anggreini, P; Ardianto, C; Khotib, J; Rahmadi, M, 2019)	2.68
"Quercetin is a bioactive flavonoid which abundantly exists in vegetables and fruits. "	( Quercetin Attenuates Decrease of Thioredoxin Expression Following Focal Cerebral Ischemia and Glutamate-induced Neuronal Cell Damage. Jin, YB; Kang, JB; Koh, PO; Park, DJ; Shah, FA, 2020)	3.44
"Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. "	( Neuroprotective Effects of Quercetin in Alzheimer's Disease. Akkol, EK; Aschner, M; Cheang, WS; Khan, H; Ullah, H, 2019)	2.25
"Quercetin is a kind of distinctive bioactive flavonoid that has potent anti-oxidant, anti-inflammatory and anti-diabetic properties. "	( Quercetin attenuates high glucose-induced injury in human retinal pigment epithelial cell line ARPE-19 by up-regulation of miR-29b. Li, H; Shi, J; Wang, H; Wang, X, 2020)	3.44
"Quercetin is a natural flavonoid with potential anti-cancer properties without significant cytotoxicity in normal tissues."	( Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway. Cai, Y; He, GQ; Jin, J; Li, SH; Li, Y; Wang, J; Wang, Z; Zhu, SX, 2020)	2.72
"Quercetin is a flavonoid which has potent anti-inflammatory, antibacterial, and antioxidant effect. "	( Quercetin Decreased Alveolar Bone Loss and Apoptosis in Experimentally Induced Periodontitis Model in Wistar Rats. Gevrek, F; Taskan, MM, 2020)	3.44
"Quercetin is an herbal bioactive flavonoid commonly used for the treatment of metabolic and inflammatory disorders."	( Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review. Alizadeh, M; Hajizadeh-Sharafabad, F; Jafari-Vayghan, H; Maleki, V; Pourteymour Fard Tabrizi, F; Vaezi, M, 2020)	2.72
"Quercetin is a natural product that has been shown to induce tumor apoptosis and necrosis through multiple mechanisms. "	( Quercetin promotes the survival of granulocytic myeloid-derived suppressor cells via the ESR2/STAT3 signaling pathway. Hu, C; Ma, Z; Xia, Y; Yi, H; Yu, M, 2020)	3.44
"Quercetin is a flavonoid possessing neuroprotective effects."	( Quercetin is protective against short-term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice. Chen, LH; Li, RY; Shen, QL; Wan, Z; Wang, G; Yang, S; Zhang, XJ; Zhang, YH; Zhong, XH; Zhou, H, 2020)	2.72
"Quercetin is a plant flavonoid and has potent antioxidant and anti-inflammatory properties. "	( Randomised clinical trial to determine the safety of quercetin supplementation in patients with chronic obstructive pulmonary disease. Barreto, TA; Comstock, AT; Han, MK; Martinez, FJ; Sajjan, US, 2020)	2.25
"Quercetin is a plant flavonoid and has antioxidative properties. "	( Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway. Hou, Q; Hu, Z; Ma, W; Tian, Z; Zang, L; Zhao, P, 2020)	3.44
"Quercetin is a flavonoid belonging to phytoestrogens family and may be useful in treatment of reproductive disorders."	( Ameliorative effects of quercetin on the preimplantation embryos development in diabetic pregnant mice. Alaee, S; Bolouki, A; Zal, F, 2020)	1.59
"Quercetin (QCT) is a natural polyphenolic compound enriched in human food, mainly in vegetables, fruits and berries. "	( Potential Implications of Quercetin and its Derivatives in Cardioprotection. Bartekova, M; Ferenczyova, K; Kalocayova, B, 2020)	2.3
"Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration."	( Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review. Al-Karaki, R; Nasr, M, 2020)	1.51
"Quercetin is a flavonol from the flavonoid group of polyphenols, which positively affects human health due to its anti-cancer, anti-inflammatory, anti-microbial and cardioprotective effects. "	( Quercetin-Mediated Apoptosis and Cellular Senescence in Human Colon Cancer. Becer, E; Kabadayı, H; Özsoy, S; Vatansever, HS; Yücecan, S, 2020)	3.44
"Quercetin (Que) is a kind of flavonoid that can protect many tissues from the toxic effect of heavy metals."	( Protective effect of quercetin on rat testes against cadmium toxicity by alleviating oxidative stress and autophagy. Liu, Z; Wang, J; Wang, K; Yang, Z; Zhu, H, 2020)	1.6
"Quercetin is a dietary antioxidant with strong redox modulating capacities that is suggested to exert part of its antioxidative effects via activation of the redox-sensitive transcription factor Nrf2 that regulates endogenous antioxidant levels."	( The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice. Albrecht, C; Bartholome, R; Bast, A; Boots, AW; Claessen, SMH; Drittij, MJ; Jonkers, L; Rosenbruch, M; Schins, RPF; van Schooten, FJ; Veith, C, 2020)	1.59
"Quercetin is a flavonoid with high anti-tumour activity against different cancers that can be used with cisplatin to enhance its efficacy and also are seen to sensitise cancer cells into chemotherapy."	( Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review. Ashrafizadeh, M; Najafi, M; Tavakol, S; Zarrabi, A, 2022)	1.81
"Quercetin is a part of natural flavonoids in plant polyphenols."	( Quercetin for myocardial ischemia reperfusion injury: A protocol for systematic review and meta-analysis. Kong, Y; Li, L; Lu, L; Ma, X; Wang, J; Yang, W; Zheng, J, 2020)	2.72
"Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies."	( Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Berrill, M; Catravas, JD; Colunga Biancatelli, RML; Marik, PE, 2020)	2.72
"Quercetin is a flavonoid commonly found in vegetables and fruits and has been reported to exert numerous pharmacological activities such as enhancing antioxidant capacity or suppressing inflammation."	( Dietary Quercetin Alleviated DSS-induced Colitis in Mice Through Several Possible Pathways by Transcriptome Analysis. Dong, Y; Lei, J; Zhang, B, 2020)	1.71
"Quercetin is a potent antioxidant flavonoid widely distributed in fruits and vegetables and has shown protective effects against dexamethasone-induced skeletal muscle atrophy."	( Effect of Quercetin on Dexamethasone-Induced C2C12 Skeletal Muscle Cell Injury. Chen, C; Chen, FA; Chen, HC; Chiu, YJ; Chung, MI; Lu, CC; Wu, YT; Yang, JS, 2020)	1.68
"Quercetin is a flavonoid, its glycosides and aglycone are found in significant amounts in several plants and dietary supplements. "	( Inhibitory Effects of Quercetin and Its Main Methyl, Sulfate, and Glucuronic Acid Conjugates on Cytochrome P450 Enzymes, and on OATP, BCRP and MRP2 Transporters. Fliszár-Nyúl, E; Kroon, PA; Kuffa, K; Mohos, V; Needs, PW; Özvegy-Laczka, C; Poór, M; Telbisz, Á; Ungvári, O, 2020)	2.32
"Quercetin is a plant-derived flavonoid suggested to have potent anticancer properties."	( Quercetin Inhibits Proliferation and Induces Apoptosis of B16 Melanoma Cells Berry, IM; Kumari, D; Moore, TC; Soll, F; Ternent, C, )	2.3
"Quercetin is a phytoestrogen reported to accelerate skin wound healing, but its effect on EpSCs is unknown."	( Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway. Feng, J; Fu, Y; Hou, R; Jin, G; Ju, J; Le, Y; Liu, J; Su, H; Wan, D; Wang, Z; Zhang, G; Zhang, P; Zhao, Q, 2020)	2.72
"Quercetin is a flavonoid contained in subarctic trees with freeze resistance and is known to be a strong antioxidant."	( Effect of quercetin on the motility of cryopreserved canine spermatozoa. Harakawa, S; Kawasaki, Y; Sakurai, D; Suzuki, H; Tsuchida, M; Yoshihara, T, 2020)	1.68
"Quercetin is a yellow pigment that is found in many common dietary plants, and that protects against oxidative stress, inflammation, and arteriosclerosis. "	( Quercetin enhances motility in aged and heat-stressed Caenorhabditis elegans nematodes by modulating both HSF-1 activity, and insulin-like and p38-MAPK signalling. Sakamoto, K; Sugawara, T, 2020)	3.44
"Quercetin is a kind of typical flavonoid, mainly found in various vegetables, fruits and Chinese herbs that are consumed daily, with the functions of anti-oxidation, anti-tumor, prevention and treatment of cardiovascular and cerebrovascular diseases. "	( [Research progress on antitumor activity of quercetin derivatives]. Feng, YL; Lu, LP; Zhai, GY, 2020)	2.26
"Quercetin is a flavonoid abundantly found in fruits and vegetables. "	( Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence. Chin, KY; Ima-Nirwana, S; Wong, SK, 2020)	3.44
"Quercetin is a natural flavonoid that occurs in fruits and vegetables. "	( The protective effect of quercetin on retinal inflammation in mice: the involvement of tumor necrosis factor/nuclear factor-κB signaling pathways. Ho, TY; Hsiang, CY; Liao, YF; Lin, KA; Liu, IC; Lo, HY; Lo, YC, 2020)	2.3
"Quercetin (Que) is a flavonoid associated with high oxygen radical scavenging activity and potential neuroprotective activity against Alzheimer's disease. "	( Preparation and Biophysical Characterization of Quercetin Inclusion Complexes with β-Cyclodextrin Derivatives to be Formulated as Possible Nose-to-Brain Quercetin Delivery Systems. Andreadelis, I; Athanasiadou, I; Banella, S; Chatziathanasiadou, MV; Chountoulesi, M; Colombo, G; Dallas, P; Demetzos, C; Diamantis, DA; Javornik, U; Manta, K; Mavromoustakos, T; Moschovou, K; Naziris, N; Papakyriakopoulou, P; Plavec, J; Rekkas, DM; Spaneas, D; Tzakos, AG; Vakali, V; Valsami, G, 2020)	2.26
"Quercetin is a natural flavonoid which has been reported to be analgesic in different animal models of pain. "	( Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin. Cao, Y; Liang, Y; Pang, J; Wu, X; Xu, Z; Zhou, P, 2020)	2.22
"Quercetin is a flavonol that is known to have numerous beneficial biological effects such as an anti-fibrotic effect. "	( Suppressive effect of quercetin against bleomycin-induced epithelial-mesenchymal transition in alveolar epithelial cells. Deguchi, J; Izumi, M; Kawami, M; Senoo, S; Takano, M; Yumoto, R, 2020)	2.32
"Quercetin is a flavonoid produced as a defense by plants. "	( Effects of Quercetin on the Growth and Expression of Immune-Pathway-Related Genes in Silkworm (Lepidoptera: Bombycidae). Guo, P; Kang, Z; Ren, F; Shi, G; Zhou, Y, 2020)	2.39
"Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases."	( Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke. Araújo, NPS; Bezerra, FS; Cangussú, SD; Castro, TF; Costa, GP; Machado-Junior, PA; Matos, NA; Oliveira, M; Souza, ABF; Talvani, A; Vieira, PMA, 2020)	1.59
"Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement."	( Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury. Diniz, LRL; Duarte, ABS; Sousa, DP; Souza, MTS, 2020)	1.53
"Quercetin is a flavonoid exclusively found in different vegetables, herbs, and fruits."	( Quercetin in Attenuation of Ischemic/Reperfusion Injury: A Review. Ashrafizadeh, M; Entezari, M; Esmaeili, H; Hushmandi, K; Najafi, M; Raei, M; Saleki, H; Samarghandian, S; Shahinozzaman, M; Zabolian, A; Zarrabi, A, 2021)	2.79
"Quercetin is a bioflavonoid with potential antioxidant properties. "	( Protective Effect of Quercetin against H Cheng, X; Hu, Y; Peng, W; Tong, X; Yang, J; Yi, M; Yi, P; Zhang, Z, 2020)	2.32
"Quercetin is a compound belonging to the flavonols class and has shown therapeutic effects against influenza virus."	( Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus. Ghavami, S; Hudy, D; Markowski, J; Mehrbod, P; Shyntum, D; Łos, MJ, 2020)	2.72
"Quercetin is a polyhydroxy flavone compound with activities such as anti-cancer, anti-inflammatory, antibacterial, antiviral, hypoglycemic and anti-hypertensive, immunomodulation and cardiovascular protection."	( [Interaction between quercetin and DNA]. Wang, Y, 2020)	1.6
"Quercetin is a plant-derived flavonoid with several pharmacological activities."	( Enlightening the neuroprotective effect of quercetin in epilepsy: From mechanism to therapeutic opportunities. Akyuz, E; Angelopoulou, E; Dundar, HE; Paudel, YN; Polat, AK, 2021)	1.61
"Quercetin is a flavonoid compound widely present in plants and exhibits a variety of biological activities. "	( Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine. Li, P; Long, M; Wang, T; Yang, D, 2020)	3.44
"Quercetin is a natural flavonol antioxidant found in various plant sources and food samples. "	( The therapeutic use of quercetin in ophthalmology: recent applications. Du, X; Wang, H; Zhao, L, 2021)	2.37
"Quercetin is a natural flavonoid with beneficial effects in the diabetic animal model, but data related to its effect on histological change and adiponectin system in the placenta of GDM are limited."	( Quercetin improved histological structure and upregulated adiponectin and adiponectin receptors in the placenta of rats with gestational diabetes mellitus. Khazaeel, K; Mahabady, MK; Ranjbar, R; Shamsi, MM; Tabandeh, MR, 2021)	2.79
"Quercetin (QC) is a flavonoid with antioxidant activity, however, high liposolubility makes it difficult to remain in the viable skin layer."	( A topical formulation containing quercetin-loaded microcapsules protects against oxidative and inflammatory skin alterations triggered by UVB irradiation: enhancement of activity by microencapsulation. Baracat, MM; Casagrande, R; da Rocha, C; Georgetti, SR; Lopez, RFV; Martinez, RM; Medeiros, DC; Sfeir, N; Vale, DL; Verri, WA; Vicentini, FTMC, 2021)	1.62
"Quercetin is a polyphenolic flavonoid that has reported to block the binding of adenosine to A1 receptors at central nervous system and increase calcium release from the sarcoplasmic reticulum at skeletal muscle. "	( Quercetin ingestion modifies human motor unit firing patterns and muscle contractile properties. Holobar, A; Watanabe, K, 2021)	3.51
"Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. "	( Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5- Barker, D; Fedrizzi, B; Leung, E; Lo, S, 2021)	2.06
"Quercetin is a well-known antioxidant and a plant polyphenolic of flavonoid group found in many fruits, leaves, and vegetables. "	( Inhibitory Effect of Quercetin on Propionibacterium acnes-induced Skin Inflammation. Jeon, YD; Jin, JS; Kang, SH; Lim, HJ; Song, YJ, 2021)	2.38
"Quercetin (QC) is a dietary bioflavonoid that can be conjugated with nanoparticles to facilitate its brain bioavailability. "	( Quercetin‑conjugated superparamagnetic iron oxide nanoparticles modulate glucose metabolism-related genes and miR-29 family in the hippocampus of diabetic rats. Dehghanian, F; Dini, S; Ebrahimpour, S; Esmaeili, A; Zakeri, M, 2021)	3.51
"Quercetin is an inhibitor of the PI3K pathway; however, its protective effects against chemotherapy-induced follicle loss in mice have not been established."	( Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice. Cong, Y; Gao, H; Kuang, Y; Li, J; Long, H; Lyu, Q; Yu, S, 2021)	2.79
"Quercetin is a flavonoid present in a wide variety of plant resources. "	( Design and optimization of quercetin-based functional foods. Lai, WF; Wong, WT, 2022)	2.46
"Quercetin is a well-known plant flavonoid with neuroprotective properties. "	( Quercetin relieves D-amphetamine-induced manic-like behaviour through activating TREK-1 potassium channels in mice. Bai, Z; Guo, B; Li, R; Liu, H; Mao, H; Ren, K; Wang, W; Wu, S; Xue, Q; Yao, H, 2021)	3.51
"Quercetin is a member of the flavonoid group of compounds, which is abundantly present in various dietary sources. "	( Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration. Abruzzese, V; Bisaccia, F; Carmosino, M; Koshal, P; Martinelli, F; Matera, I; Milella, L; Ostuni, A, 2021)	2.47
"Quercetin (QCT) is a substance with preventive effects in treatment of cardiovascular diseases and diabetes."	( Matrix Metalloproteinases and Their Role in Mechanisms Underlying Effects of Quercetin on Heart Function in Aged Zucker Diabetic Fatty Rats. Barančík, M; Barteková, M; Boťanská, B; Ferenczyová, K; Fogarassyová, M; Kindernay, L, 2021)	1.57
"Quercetin is a well-studied natural product with multiple pharmacological properties. "	( Dual effects of quercetin on protein digestion and absorption in the digestive tract. Chen, D; Cheng, Y; Huang, M; Liao, CK; Lin, H; Liu, Y; Xu, P; Yu, S; Zhou, Y, 2021)	2.41
"Quercetin is a natural flavonoid compound that can be found in many foods."	( Quercetin inhibits invasion and angiogenesis of esophageal cancer cells. Cheng, D; Li, CL; Liu, KD; Liu, Y; Sun, ZQ; Xu, QQ, 2021)	2.79
"Quercetin (Que) is a major active flavonoid component isolated from HT and is one of the quality control indexes of HT."	( Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis. Ba, X; Chen, Z; Han, L; Huang, Y; Lin, W; Qin, K; Shen, P; Tu, S, 2021)	2.79
"Quercetin is a flavonoid with significant pharmacological effects and promising therapeutic potential."	( Mechanistic insights and perspectives involved in neuroprotective action of quercetin. Abdel-Daim, MM; Akhtar, MF; Albadrani, GM; Grewal, AK; Kamel, M; Najda, A; Rahman, MH; Saleem, A; Sharma, D; Sharma, V; Singh, M; Singh, TG; Walasek-Janusz, M, 2021)	1.57
"Quercetin is a poorly water-soluble flavonoid with many benefits to human health. "	( Solid Lipid Nanoparticles Produced via a Coacervation Method as Promising Carriers for Controlled Release of Quercetin. Consumi, M; Leone, G; Magnani, A; Talarico, L; Tamasi, G, 2021)	2.28
"Quercetin is a powerful antioxidant, so it potently provides plant tolerance against several biotic and abiotic stresses."	( The role of quercetin in plants. Arif, Y; Bajguz, A; Hayat, S; Singh, P, 2021)	1.72
"Quercetin (QCT) is a dietary flavonoid with many beneficial effects (e.g., antioxidant, antiaging, antidiabetic, antifungal effects, and regulation of gastrointestinal motor activity in human); furthermore, it induces apoptosis, cell cycle arrest, and differentiation."	( Is Quercetin Beneficial for Colon Cancer? A Cell Culture Study, Using the Apoptosis Pathways. Armağan, İ; Bayram, D; Özgöçmen, M; Şenol, N; Sevimli, M; Türel, GY, 2022)	2.79
"Quercetin is a flavonoid existing in different herbs, fruits, seeds, nuts and tea. "	( The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways. Ayatollahi, SA; Ghafouri-Fard, S; Khanbabapour Sasi, A; Shoorei, H; Taheri, M, 2021)	2.33
"Quercetin is a flavonoid compound with a variety of biological properties that is widely distributed throughout the plant kingdom. "	( Toxicity of thioacetamide and protective effects of quercetin in zebrafish (Danio rerio) larvae. Cheng, B; Deng, Y; Guo, J; Huang, Y; Liu, Y; Lu, H; Meng, Y; Wang, K; Xiong, G; Zhang, J; Zhong, K, 2021)	2.31
"Quercetin is a natural flavonoid that is widely present in fruits, herbs, and vegetables."	( Potential Implications of Quercetin in Autoimmune Diseases. Ba, X; Chen, Z; Deng, X; Han, L; Huang, Y; Lin, W; Qin, K; Shen, P; Tu, S, 2021)	1.64
"Quercetin is a polyphenolic flavonoid occurring in leaves, stems, flowers and fruits of many plants. "	( Quercetin affects uterine smooth muscle contractile activity in gilts. Burmańczuk, A; Grabowski, T; Jaroszewski, JJ; Markiewicz, W; Vyniarska, A; Zygmuntowicz, A, 2021)	3.51
"Quercetin is a flavonoid agent detected in fruits and vegetables with anti-inflammatory, antioxidant, and anticancer effects. "	( Emerging impact of quercetin in the treatment of prostate cancer. Abak, A; Basiri, A; Ghafouri-Fard, S; Karimi, A; Shabestari, FA; Shoorei, H; Taheri, M; Vaezi, S, 2021)	2.39
"Quercetin is a polyphenolic compound, the effects of which raise scientists' doubts. "	( Advantageous/Unfavorable Effect of Quercetin on the Membranes of SK-N-SH Neuroblastoma Cells. Barbasz, A; Dyba, B; Kreczmer, B; Rudolphi-Szydło, E, 2021)	2.34
"Quercetin is a natural product that is sold as a supplement in health food stores. "	( Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). Denslow, ND; Laurence Souders, C; Martyniuk, CJ; Zhang, JL, 2017)	3.34
"Quercetin is a typical flavonol with atheroprotective effects, but the effect of quercetin on dendritic cell (DC) maturation in relation to atherosclerosis has not yet been clearly defined. "	( Quercetin protects against atherosclerosis by inhibiting dendritic cell activation. Lin, W; Ling, W; Wang, D; Wang, W, 2017)	3.34
"Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties."	( Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative. Alrushaid, S; Anderson, HD; Chaboyer, K; Davies, NM; El-Kadi, AOS; Forrest, ML; Maayah, ZH; Sayre, CL; Senadheera, SN; Zhao, Y, 2017)	1.18
"Quercetin is a bioactive compound with anti-inflammatory, antioxidant and anticancer properties. "	( Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression. Devaraj, H; Devaraj, SN; Kasinathan, NK; Murali, MR; P, A; Raja, SB; Rajendiran, V; Venkatabalasubramanian, S, 2017)	2.17
"Quercetin (QC) is a dietary flavonoid abundant in many natural plants. "	( Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway. Chen, H; Han, L; Liu, H; Lu, C; Wang, M; Yan, Y; Zhao, H, 2017)	3.34
"Quercetin is a flavonoid that has been shown to have anti-oxidation, anti-inflammation, anti-allergic, anti-viral, and anti-cancer activities. "	( Effects of quercetin on proliferation and migration of human glioblastoma U251 cells. Li, CL; Lin, Y; Liu, Y; Lv, W; Qu, XG; Tang, ZG; Wang, GB, 2017)	2.29
"Quercetin is an abundant flavonoid in fruits, vegetables such as onion, tea leaves, cranberry, radish leaves etc. "	( Solvent effect in the synthesis of hydrophobic drug-loaded polymer nanoparticles. Pal, S; Saha, C, 2017)	1.9
"Quercetin is a flavonoid with many beneficial uses."	( A Study of the Modulating Action of Quercetin on Biochemical and Histological Alterations Induced by Lead Exposure in the Liver and Kidney of Rats. Elsawy, H; Mohammed, GM; Sedky, A, 2017)	1.45
"Quercetin is a bioflavonoid found ubiquitously in fruits and vegetables, and has antioxidative activity."	( Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells. Bao, D; Liu, H; Pang, X; Wang, J, 2017)	1.5
"Quercetin is a redox-active plant-derived flavonoid with potential anticancer effects, stemming largely from its interaction with a number of proteins, and in particular from inhibition of pro-life kinases. "	( Potential anti-cancer activity of 7-O-pentyl quercetin: Efficient, membrane-targeted kinase inhibition and pro-oxidant effect. Biasutto, L; Espina, V; Liotta, L; Mattarei, A; Paradisi, C; Sassi, N; Zoratti, M, 2017)	2.16
"Quercetin is a flavonoid widely studied as a chemopreventive agent in different types of cancer. "	( Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis. Baltiérrez-Hoyos, R; Carrasco-Torres, G; Martínez-Guerra, AA; Monroy-Ramírez, HC; Romero-Tlalolini, MLÁ; Sánchez-Chino, X; Vásquez-Garzón, VR; Villa-Treviño, S, 2017)	3.34
"Quercetin is a flavonoid that exhibits powerful antioxidant activity."	( Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice. Dong, F; Fan, H; Jiang, J; Qu, X; Wang, S; Wang, Y; Wu, D; Yang, X; Yao, R, 2017)	2.62
"Quercetin is a flavonoid with antioxidant properties."	( Effects of ciprofloxacin on fetal rat liver during pregnancy and protective effects of quercetin. Cetin, A; Demirtas, S; Dogan, Z; Elbe, H; Soysal, H; Taslidere, E, 2017)	1.4
"Quercetin is a fragile bioactive compound. "	( Fluorescence Lifetime and UV-Vis Spectroscopy to Evaluate the Interactions Between Quercetin and Its Yeast Microcapsule. Pham-Hoang, BN; Waché, Y; Winckler, P, 2018)	2.15
"Quercetin is a vital dietary flavonoid that has been shown to have a variety of anticancer effects, as it induces cell cycle arrest, apoptosis, and differentiation and is involved in cell adhesion, metastasis and angiogenesis."	( Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells. Bai, B; Fan, P; Hong, W; Lan, H; Qian, D; Zhu, J, 2017)	2.62
"Quercetin is a major dietary flavonoid that has been shown to induce cell growth inhibition and apoptosis in human lung cancer cell lines."	( Interactions of quercetin with receptor tyrosine kinases associated with human lung carcinoma. Antony, P; Baby, B; Vijayan, R, 2018)	1.55
"Quercetin is a flavonoid with high antioxidant activity that provides benefits to health."	( Production of Cornstarch Granules Enriched with Quercetin Liposomes by Aggregation of Particulate Binary Mixtures Using High Shear Process. Dacanal, GC; Galeskas, H; Pinho, SC; Toniazzo, T, 2017)	1.43
"Quercetin is a common flavonoid which is found in many fruits and red wine."	( Quercetin-Induced AMP-Activated Protein Kinase Activation Attenuates Vasoconstriction Through LKB1-AMPK Signaling Pathway. Choi, HC; Kim, JR; Kim, SG, 2018)	2.64
"Quercetin (Q1) is a flavonoid widely present in plants and endowed with several pharmacological properties mostly due to its antioxidant potential. "	( New insights for the use of quercetin analogs in cancer treatment. Caruso, A; Ceramella, J; Grande, F; Iacopetta, D; Mordocco, RA; Muià, N; Plutino, MR; Puoci, F; Rosano, C; Saturnino, C; Scrivano, L; Sinicropi, MS, 2017)	2.19
"Quercetin is a flavonoid that has roles in both cytoprotection and cytotoxicity. "	( Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells. Matsumoto, R; Nakagawa, H; Nishimura, K; Yonezawa, Y, 2017)	2.3
"Isoquercetin is a glycoside derivative with antihistamine properties of quercetin, a natural polyphenol flavonoid found in many plants."	( Use of Isoquercetin in the Treatment of Prurigo Nodularis. Basak, SA; Marks, AG; Neely, J; Pennesi, CM, 2017)	1.37
"Quercetin is a polyphenol found in food that has numerous health benefits. "	( Quercetin metabolism by fecal microbiota from healthy elderly human subjects. Hoshi, C; Kobori, M; Nishihira, J; Nishimura, M; Takahashi, S; Tamura, M; Tomita, J, 2017)	3.34
"Quercetin is a flavonoid presenting cytotoxicity against different cancer cell lines. "	( Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation. Bellou, S; Chatziathanasiadou, MV; Geromichalos, GD; Geromichalou, EG; Katsikoudi, A; Sayyad, N; Stylos, E; Tzakos, AG; Vrettos, EI, 2018)	2.18
"Quercetin (QUE) is a naturally occurring flavonoid compound."	( Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells. He, F; Li, S; Luo, T; Shen, XY; Ting, OY; Wang, HQ; Xu, J, 2018)	2.64
"Quercetin is a polyphenol that has been reported to be an active oxygen scavenger as well as a functional adenosine monophosphate-activated protein kinase (AMPK) activator."	( Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease. Azam, A; Barnes, PJ; Ito, K; Mercado, N; Mitani, A; Vuppusetty, C, )	2.3
"Quercetin (QCT) is a flavonol present in many vegetables, it is proved to show chemo preventive effect against lung, cervical, prostate, breast and colon cancer due to its anti-inflammatory, anti-tumor and anti-oxidant property. "	( Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways. Liu, H; Zhou, M, 2017)	2.22
"Quercetin is a member of flavonoid with strong antioxidant properties, and our results indicate that the use of ciprofloxacin in pregnancy can result damage to fetal brain tissue."	( Effects of ciprofloxacin and quercetin on fetal brain development: a biochemical and histopathological study. Cetin, A; Dogan, Z; Elibol, E; Turkoz, Y; Vardi, N, 2019)	1.53
"Quercetin is a dietary flavonoid which has an effect on inflammation, angiogenesis and vascular inflammation. "	( Quercetin decrease somatic cells count in mastitis of dairy cows. Burmańczuk, A; Grabowski, T; Hola, P; Kowalski, C; Milczak, A; Piech, T; Wojciechowska, B, 2018)	3.37
"Quercetin is a flavonoid with antioxidant, antiangiogenic, and chemoprotective properties but the mitochondrial effects are less characterized."	( Quercetin exerts an inhibitory effect on cellular bioenergetics of the B164A5 murine melanoma cell line. Ancușa, S; Danciu, C; Dehelean, C; Duicu, O; Muntean, D; Pavel, I; Sturza, A, 2018)	2.64
"Quercetin is a ubiquitous flavonoid found in many plants. "	( Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain. Mashayekhi, FJ; Owji, AA; Rahvar, M, 2018)	2.33
"As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling."	( Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension. Belo, VA; Castro, MM; Ceron, CS; do Vale, GT; Gonzaga, NA; Mendes, AS; Parente, JM; Pereira, SC; Tanus-Santos, JE; Tirapelli, CR, 2018)	2.44
"Quercetin is a typical flavonoid that is commonly found in fruits and vegetables and has versatile biological effects."	( Quercetin and iron metabolism: What we know and what we need to know. Luo, G; Tang, Y; Xiao, L; Yao, P, 2018)	2.64
"Quercetin is a well-known flavonoid naturally occurring in most of the plant foods and is often found in the human diet. "	( MicroRNAs as molecular targets of quercetin and its derivatives underlying their biological effects: A preclinical strategy. Li, D; Li, F; Sun-Waterhouse, D; Wang, D; Xin, L, 2019)	2.24
"Quercetin is a major flavonoid in various plants. "	( Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish. Muthuraman, A; Rishitha, N, 2018)	2.17
"Quercetin is a flavonoid with strong antioxidant and antiinflammatory activities considered as a potential drug candidate for skin exogenous supplementation. "	( Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin. Bégu, S; Devoisselle, JM; Hatahet, T; Hommoss, A; Morille, M; Müller, RH, 2018)	2.15
"Quercetin is a flavonoid compound that is abundant in vegetables and fruits."	( Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model. Koh, PO; Park, DJ; Shah, FA, 2018)	2.64
"Quercetin is a major flavonoid, present as its glycosidic forms in plant foods. "	( Lymphatic metabolites of quercetin after intestinal administration of quercetin-3-glucoside and its aglycone in rats. Hamada, M; Ikushiro, S; Kato, Y; Kinjo, C; Murota, K; Nakajima, N; Nakamura, T; Nakamura, Y; Nishikawa, M, 2018)	2.23
"Quercetin is a plant polyphenol from the flavonoid group that plays a fundamental role in controlling homeostasis due to its potent antioxidant properties. "	( Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines. Aghapour, F; Barari, L; Kani, SNM; Kazemi, S; Moghadamnia, AA; Morakabati, P; Nicolini, A; Rezazadeh, L, 2018)	3.37
"Quercetin is a flavonoid that has anti‑inflammatory, anti‑oxidant and lipid metabolic effects. "	( Quercetin protects against ox‑LDL‑induced injury via regulation of ABCAl, LXR‑α and PCSK9 in RAW264.7 macrophages. Cao, H; Chen, C; Jia, Q; Li, S; Shen, D; Xing, SL, 2018)	3.37
"Quercetin is a bioflavonoid substance that acts an antioxidant agent and exerts a neuroprotective effect against cerebral ischemia."	( Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach. Koh, PO; Park, DJ; Shah, FA, 2018)	1.45
"Quercetin is a potential antioxidant and free radical scavenger that is widely found in fruits, vegetables, and leaves."	( Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro. Gao, Q; Jin, H; Lv, C; Qian, X; Wang, J; Xu, J; Zhu, H, 2018)	2.64
"Quercetin is a flavonoid found in a variety of herbs with anti-fibrosis function."	( Quercetin ameliorates pulmonary fibrosis by inhibiting SphK1/S1P signaling. Cai, Y; Chen, X; Zhang, W; Zhang, X, 2018)	2.64
"Quercetin is a bioactive flavonoid in the class of polyphenols with a free-radical scavenging ability and anti-inflammatory activity."	( Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation. Chai, G; Liu, S; Tian, L; Wang, B; Wen, B, 2018)	1.49
"Quercetin is a flavonoid compound that is widely present in food and drink. "	( Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. Huang, X; Liu, Y; Shi, S; Wan, J; Yang, C; Yang, T; Zhang, R; Zhang, Y; Zhou, J, 2018)	3.37
"Quercetin is a naturally-occurring flavonoid claimed to exert many beneficial health effects. "	( The effect of quercetin on the electrical properties of model lipid membranes and human glioblastoma cells. Cechowska-Pasko, M; Gál, M; Kotyńska, J; Krętowski, R; Kruszewski, M; Kusaczuk, M; Naumowicz, M, 2018)	2.28
"Quercetin (Que) is a polyphenolic compound that shows good anti-cancer, anti-inflammation and anti-oxidation effects."	( Effects of Quercetin on Proliferation and H₂O₂-Induced Apoptosis of Intestinal Porcine Enterocyte Cells. Chen, H; Chen, Z; Lei, H; Su, J; Xu, G; Yuan, Q, 2018)	1.59
"Quercetin (QCT) is a flavonoid, abundantly present in plants and has gained considerable interest for its antioxidant property and chemo preventive activity. "	( In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. Baksi, R; Borse, SP; Nivsarkar, M; Rana, R; Sharma, V; Singh, DP, 2018)	2.17
"Quercetin is a flavonoid with many physiological effects. "	( Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin. Hara, H; Ikushiro, S; Nishikawa, M; Oyama, M; Tanaka, S, 2018)	2.11
"Quercetin is a dietary flavonoid that exerts anti-oxidant, anti-inflammatory, and anti-cancer properties."	( Quercetin preferentially induces apoptosis in KRAS-mutant colorectal cancer cells via JNK signaling pathways. Chen, D; Liao, S; Ma, Q; Wang, T; Wang, Y; Yang, Y; Zhang, J; Zheng, Y, 2019)	2.68
"Both quercetin, which is a phosphoinositide 3-kinase inhibitor, and the phospholipase C inhibitor U-73122 reduced oxytocin-induced elevation of intracellular calcium concentration."	( Projection length stimulated by oxytocin is modulated by the inhibition of calcium signaling in U-87MG cells. Alanazi, M; Bacova, Z; Bakos, J; Castejon, AM; Kiss, A; Lestanova, Z; Ostatnikova, D; Puerta, F; Reichova, A; Zatkova, M, 2018)	0.94
"Quercetin is a phenolic compound occurring in many food plants and agricultural crops. "	( Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids. Almeda, RA; Reyes, CT; Rodriguez, EB; Vidallon, MLP, 2019)	2.21
"Quercetin (QR) is a multipotent flavonoid that functions as an antioxidant and protects against inflammation and neurodegeneration."	( Protective effects of quercetin against brain injury in a rat model of lipopolysaccharide-induced fetal brain injury. Liu, C; Wang, Q, 2018)	1.52
"Quercetin (Que) is an effective antioxidant and free radical scavenger against oxidative/nitrosative stress."	( Protective effects of quercetin from oxidative/nitrosative stress under intermittent hypobaric hypoxia exposure in the rat's heart. Baltaru, D; Chiş, IC; Coseriu, A; Dumitrovici, A; Moldovan, R; Mureşan, A; Radu, BC, 2018)	1.52
"Quercetin (Qu), is a flavonoid known to have anti-diabetic effects owing to its antioxidant property, thus promoting regeneration of the pancreatic islets, ultimately increasing insulin secretion. "	( Design, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment. Ajmal, G; Mishra, B; Mittal, P; Singh, J; Vasant Bonde, G, 2018)	2.16
"Quercetin (QC) is a phyto-derived bioactive flavone with numerous beneficial activities."	( Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats. Beheshti, S; Ebrahimpour, S; Esmaeili, A, 2018)	1.6
"Quercetin is a flavonoid widely found in plants and marketed to the public as a supplement. "	( Quercetin Attenuates Neuropathic Pain in Rats with Spared Nerve Injury. Arakawa, K; Kaku, R; Kurita, M; Matsuoka, Y; Morimatsu, H; Muto, N; Omiya, H; Taniguchi, A, 2018)	3.37
"Quercetin (Q) is a natural polyphenol with high radical scavenging capacity, but low in vivo bioavailability. "	( Effects of conjugation metabolism on radical scavenging and transport properties of quercetin - In silico study. Amić, A; Lučić, B; Marković, Z; Matić, S; Milenković, D; Stepanić, V, 2019)	2.18
"Quercetin is a well-known plant flavonoid that is reported to have anticancer actions in vitro and in vivo."	( Potential of the Flavonoid Quercetin to Prevent and Treat Cancer - Current Status of Research. Břetislav, G; Jana, N; Pavel, S; Pavla, U, )	1.15
"Quercetin is a direct inhibitor of mTOR but did not influence the activity of Akt at the tested concentration range."	( Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin. Cai, J; Chen, Y; Goldfine, H; Huang, Y; Shaw, AM; Tian, J, 2018)	1.43
"Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects."	( An Overview, Advantages and Therapeutic Potential of Nonpeptide Positive Allosteric Modulators of Glucagon-Like Peptide-1 Receptor. Anastasijevic, M; Anderluh, M; Jukic, M; Kocic, G; Lazarevic, J; Smelcerovic, A; Tomovic, K, 2019)	1.24
"Quercetin (Que) is a flavonoid that possesses anti-oxidative activities, exerts myocardial protection."	( Quercetin protects cardiomyocytes against doxorubicin-induced toxicity by suppressing oxidative stress and improving mitochondrial function via 14-3-3γ. Chen, X; He, H; He, M; Luo, Y; Peng, X; Xu, Q; Yin, D; You, J, 2019)	2.68
"Quercetin is a flavonoid present in fruits and vegetables which possess anticancer properties."	( Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line. Elayapillai, SP; Jagadeesan, A; Teekaraman, D; Viswanathan, MP, 2019)	2.68
"Quercetin is a flavonoid polyphenolic compound present in fruits and vegetables that has proven anti-inflammatory activity. "	( Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-α-activated retinal pigment epithelial cells. Cheng, CY; Cheng, SC; Huang, TH; Huang, WC; Pang, JS; Wu, YH, 2019)	2.25
"Quercetin is a plant polyphenol with biological activities such as anti-inflammatory, anticancer, antidiabetic, neuroprotective and anti-allergic. "	( Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies. Abdollahi, M; Abdurahman, A; Amini, M; Bule, M; Nikfar, S, 2019)	2.27
"Quercetin is a polyphenolic flavonoid, which is frequently found in fruits and vegetables. "	( Application of quercetin in neurological disorders: from nutrition to nanomedicine. Amanzadeh, E; Esmaeili, A; Nourbakhshnia, M; Rahgozar, S, 2019)	2.31
"Quercetin is a member of the flavonoid family and has antioxidant and anti-inflammatory properties in degenerative diseases."	( Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model. Chen, Z; Feng, K; Pengcheng, L; Wang, X; Zhang, S, 2019)	2.68
"Quercetin is a flavonoid compound widely found in vegetables, fruits, and medicinal plants. "	( ESI-TOF MS analysis of complexes formed between quercetin and five metal ions in hot water and a study into their DNA cleavage activity. Liang, P; Lixia, H; Manman, H; Min, C; Weilan, C; Zhimin, L, 2019)	2.21
"Quercetin is a bioactive compound that is widely used in botanical medicine and traditional Chinese medicine due to its potent antioxidant activity. "	( Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Cui, YL; Hu, MJ; Wang, YQ; Xu, D, 2019)	2.26
"Quercetin is a common Chinese herbal medicine and has been reported to inhibit TGF‑β signaling pathway activation."	( Quercetin suppresses glomerulosclerosis and TGF‑β signaling in a rat model. Dai, E; Liu, Y; Yang, J, 2019)	2.68
"Quercetin is a dietary bioflavonoid used widely as a food supplement and is generally recognized as safe. "	( Dietary bioflavonoid quercetin modulates porcine ovarian granulosa cell functions Galik, B; Halenar, M; Klinerova, B; Kolesarova, A; Kopcekova, J; Michalcova, K; Mnahoncakova, E; Packova, D; Roychoudhury, S, 2019)	2.28
"Quercetin is a well-known flavonoid abundant in vegetables, fruits, grains, leaves, and red onions."	( Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1. Li, S; Liu, F; Pei, Y; Wang, W; Zhang, X; Zheng, K, 2019)	2.68
"Quercetin (QE) is an attractive natural compound for cancer prevention due to its beneficial anti-oxidative and anti-proliferative effects. "	( Size-Dependent Biological Effects of Quercetin Nanocrystals. Gao, J; Liu, Q; Sun, J; Yang, X; Yu, F; Zhang, H; Zheng, A, 2019)	2.23
"Quercetin (QE) is an antioxidant, anti-inflammatory, flavonoid compound. "	( Quercetin Enhances the Function and Reduces Apoptosis of Mouse Islets. Jang, HJ; Kim, SS; Oh, MY, 2019)	3.4
"Quercetin is a polyphenolic flavonoid with approved anti-tumor effect."	( Synthesis and biological evaluation of quercetin-zinc (II) complex for anti-cancer and anti-metastasis of human bladder cancer cells. Lee, YH; Tuyet, PT, 2019)	1.5
"Quercetin is a plant flavonoid that has anti-oxidant, anti-inflammatory, anti-cancer, and anti-ischemic properties. "	( Quercetin alleviates the injury-induced decrease of protein phosphatase 2A subunit B in cerebral ischemic animal model and glutamate-exposed HT22 cells. Kang, JB; Koh, PO; Park, DJ; Shah, MA, 2019)	3.4
"Quercetin is a bioflavonoid which has anti-oxidant and reno-protective abilities."	( Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME. Ma, Y; Shi, X; Song, L; Yang, S; Zhao, N, 2019)	1.5
"Quercetin is an abundant flavonoid in nature and is used in several dietary supplements. "	( Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme. Fliszár-Nyúl, E; Hetényi, C; Kroon, PA; Mladěnka, P; Mohos, V; Needs, PW; Pánovics, A; Pethő, G; Poór, M; Schilli, G, 2019)	2.27
"Quercetin (Qc) is a flavonoid found in fruits and vegetables that has several biological properties."	( Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model. Angelica Maria, SG; Gloria Patricia, CG; Luis, CH; Paula, PC, 2019)	1.55
"Quercetin is a phytochemical with disease prevention and health promotion activities that has attracted significant research attention. "	( Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables. Dai, Y; Row, KH, 2019)	2.19
"Quercetin is a natural bioflavonoid present in fruits, vegetables, seeds, berries, and tea."	( Quercetin Loaded Nanoparticles in Targeting Cancer: Recent Development. Maurya, AK; Vinayak, M, 2019)	2.68
"Quercetin is a polyphenol of great interest given its antioxidant activity and involvement in the immune response. "	( Genome-wide localization of the polyphenol quercetin in human monocytes. Atrahimovich, D; Barsheshet, Y; Khatib, S; Reuveni, E; Samson, AO; Vaya, J, 2019)	2.22
"Quercetin is an abundant dietary flavonoid that selectively clears inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis."	( Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin. Ahmed, L; Chen, X; Hickson, LJ; Jiang, K; Kim, SR; Kirkland, JL; Lerman, LO; Lohmeier, H; Ogrodnik, M; Tang, H; Tchkonia, T; Zhu, XY, 2019)	1.46
"Quercetin can acts as a prooxidant at high intake levels."	( Quercetin reduces serum homocysteine level in rats fed a methionine-enriched diet. Gao, W; Guo, C; Meng, B; Pu, L; Wei, J; Wu, J; Yang, J, 2013)	2.55
"So, quercetin appears to be a semi-specific fluorescent probe for the activity of ryanodine receptors, which in our Jurkat (clone E6.1) cell preparations probably reports the type 3 RyR activity."	( Quercetin as a fluorescent probe for the ryanodine receptor activity in Jurkat cells. Baran, I; Ganea, C; Katona, E, 2013)	2.31
"Quercetin (Qu) is a principal flavonoid compound and an excellent free-radical-scavenging antioxidant that promotes apoptosis."	( Reappraisal of the anticancer efficacy of quercetin in oral cancer cells. Chang, YC; Chen, SF; Lin, YS; Liu, CL; Nien, S; Wu, CH, 2013)	1.38
"Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. "	( Bioavailability of quercetin: problems and promises. Cai, X; Dou, J; Fang, Z; Yu, A; Zhai, G, 2013)	2.16
"Quercetin is a natural polyphenolic flavonoid that displays anti-diabetic properties in vivo. "	( Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells. Bardy, G; Bertrand, G; Cros, G; Dalle, S; Magous, R; Oiry, C; Quignard, JF; Ravier, MA; Richard, S; Virsolvy, A, 2013)	3.28
"Quercetin is an effective antioxidant and free radical scavenger against oxidative stress."	( Quercetin potentially attenuates cadmium induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats. Milton Prabu, S; Muthumani, M; Shagirtha, K, 2013)	2.55
"Quercetin is a plant-derived flavonoid that can induce apoptosis in prostate cancer cells."	( Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells. Song, L; Wang, G; Wang, H; Xing, N, 2013)	2.55
"Quercetin is an important flavonoid with antioxidant and anti-inflammatory activity."	( Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: effect on low grade inflammation. El Bassossy, HM; Fahmy, A; Hassan, NA; Mahmoud, MF, 2013)	2.55
"Quercetin is a major bioflavonoid widely present in fruits and vegetables. "	( Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells. Cho, JY; Endale, M; Kim, S; Kim, SH; Park, SC; Rhee, MH; Yang, Y, 2013)	3.28
"Quercetin is a common flavonoid polyphenol which has been shown to exert neuroprotective actions in vitro and in vivo. "	( Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection? Cole, TB; Costa, LG; Dao, K; de Laat, R; Furlong, CE; Giordano, G; Pellacani, C; Tait, L, 2013)	2.07
"Quercetin is a ubiquitous flavonoid found in vegetable foods. "	( The effects of quercetin protect cardiomyocytes from A/R injury is related to its capability to increasing expression and activity of PKCε protein. He, M; Liu, Y; Luo, Y; Peng, Y; Tang, L; Xu, T; Yi, X; Yin, D, 2013)	2.19
"Quercetin is a naturally derived PDE4-selective inhibitor found in fruits, vegetables, and tea."	( Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4. Emala, CW; Townsend, EA, 2013)	2.55
"Quercetin is a promising chemopreventive agent against cancer that inhibits tumor progression by inducing cell cycle arrest and promoting apoptotic cell death. "	( Regulation of Wnt signaling activity for growth suppression induced by quercetin in 4T1 murine mammary cancer cells. Ganbold, B; Kang, YH; Kim, H; Lee, SS; Nam, JS; Park, J; Seo, EM; Sharma, AR; Sharma, G; Song, DK, 2013)	2.07
"Quercetin is a natural flavonoid widely distributed in plants that acts as a neuroprotective agent and modulates the activity of different synaptic receptors and ion channels, including the ionotropic GABA receptors. "	( Quercetin antagonism of GABAAρ₁ receptors is prevented by ascorbic acid through a redox-independent mechanism. Alvarez, S; Beltrán González, AN; Calero, CI; Calvo, DJ; Evelson, P; Gasulla, J, 2013)	3.28
"Quercetin is a major flavonoid compound found in red wine at a much higher concentration than the phytoalexin resveratrol. "	( Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase. Chung, MY; Jang, TS; Kang, NJ; Lee, HJ; Lee, KW; Seo, SG; Song, NR, 2014)	3.29
"Quercetin is a flavonoid possessing potential chemopreventive properties."	( Quercetin: a pleiotropic kinase inhibitor against cancer. Bilotto, S; Iannitti, R; Palumbo, R; Russo, GL; Russo, M; Spagnuolo, C; Tedesco, I, 2014)	2.57
"Quercetin (QU) is a kind of natural flavonoids, with lipid-lowering, anti-inflammatory and other pharmacological activities, and minor toxic side effects."	( Quercetin: a potential natural drug for adjuvant treatment of rheumatoid arthritis. Diao, YP; Huang, SS; Ji, JJ; Li, K; Lin, Y; Zhang, HL, 2013)	2.55
"Quercetin is a widely distributed flavonoid in edible plants which prevented atherosclerosis in an animal model."	( Quercetin-3-O-glucuronide induces ABCA1 expression by LXRα activation in murine macrophages. Ohara, K; Shindo, K; Taniguchi, Y; Wakabayashi, H; Yajima, H; Yoshida, A, 2013)	2.55
"Quercetin (QT) is a potential chemotherapeutic drug with low solubility that seriously limits its clinical use. "	( Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma. Jafarian, A; Salehi, G; Varshosaz, J; Zolfaghari, B, 2014)	2.07
"Quercetin is a plant-based antioxidant traditionally used as a treatment for hepatic injury, but its poor solubility affects its bioavailability."	( Protective effects of quercetin and quercetin-5',8-disulfonate against carbon tetrachloride-caused oxidative liver injury in mice. Cui, Y; Han, Y; Sun, Y; Yang, X; Zhao, Y, 2013)	1.43
"Quercetin is a dietary flavonoid with known antitumor effects against several types of cancers by promoting apoptotic cell death and inducing cell cycle arrest. "	( Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. Ahn, KS; Cho, SK; Kim, H; Moon, JY, 2013)	3.28
"Quercetin is a dietary flavonoid with potential chemoprotective effects, but has low bioavailability because of poor aqueous solubility and low intestinal absorption. "	( Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability. Bruno, RS; Guo, Y; Lu, X; Song, D; Tran, TH, 2014)	3.29
"Quercetin is a natural flavonoid that exhibits antioxidant properties."	( Quercetin enhances exercise-mediated neuroprotective effects in brain ischemic rats. Chang, HC; Wang, PS; Wang, RY; Yang, YR, 2014)	2.57
"Quercetin (QE) is a flavonoid that can eliminate reactive oxygen species (ROS) and elicit anti-inflammatory and anti-apoptotic effects."	( Regulatory effect of quercetin on hazardous microcystin-LR-induced apoptosis of Carassius auratus lymphocytes in vitro. Fang, W; Wang, D; Wu, Y; Zhang, H, 2014)	1.44
"Quercetin is a flavonoid, which acts on estrogen receptors and causes the development of estrogen-related diseases."	( Effects of quercetin on CYP450 and cytokines in Aroclor 1254 injured endometrial cells of the pregnant rats. Lu, L; Ma, Y; Qin, J; Sun, L; Xu, L; Zhong, X, 2014)	1.51
"Quercetin is a natural flavonoid found in high quantities in fruits and vegetables, and may be a potential antioxidant and free radical scavenger."	( Anti-apoptotic and anti-oxidative roles of quercetin after traumatic brain injury. Cheng, L; Gu, JW; Kong, B; Kuang, YQ; Shu, HF; Xia, X; Yang, T; Yang, WT, 2014)	1.39
"Quercetin is an effective Hsp27 inhibitor and has been reported to facilitate tumor cell apoptosis. "	( Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27. Lan, Q; Li, RJ; Sang, DP, 2014)	3.29
"Quercetin (QUE) is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when orally administered."	( Chitosan-xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin. Caddeo, C; Díez-Sales, O; Fadda, AM; Manconi, M; Merino-Sanjuán, M; Nácher, A, 2014)	2.06
"Quercetin is a plant-derived flavonoid that is widely distributed in nature. "	( Quercetin prevents pyrrolizidine alkaloid clivorine-induced liver injury in mice by elevating body defense capacity. Cai, Z; Ji, L; Ma, Y; Pang, C; Wang, Z, 2014)	3.29
"Quercetin is a natural polyphenolic flavonoid and acts as a quencher for reactive oxygen species generated by any physical or chemical action. "	( Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice. Alam, MM; Meerza, D; Naseem, I, 2014)	2.16
"Quercetin is an abundant dietary flavonoid with well-known radical scavenging properties being often used as a reference compound in many antioxidant tests."	( Dependence of DPPH radical scavenging activity of dietary flavonoid quercetin on reaction environment. Sak, K, 2014)	1.36
"Quercetin is a potential chemopreventive agent."	( Cytotoxicity comparison of quercetin and its metabolites from in vitro fermentation of several gut bacteria. Liu, L; Ou, S; Peng, X; Wang, Y; Zhang, N; Zhang, Z, 2014)	1.42
"Quercetin is a flavonoid, of the subclass flavonols, possessing potential anticancer properties. "	( The pleiotropic flavonoid quercetin: from its metabolism to the inhibition of protein kinases in chronic lymphocytic leukemia. Russo, GL; Russo, M; Spagnuolo, C, 2014)	2.15
"Quercetin is a plant-derived bioflavonoid that was recently shown to have multiple anticancer activities in various solid tumors. "	( Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft. Chang, JL; Cheng, CW; Chien, MH; Chow, JM; Hsiao, M; Lee, LM; Lee, WJ; Lin, KH; Lin, YW; Liu, CC; Tseng, TH; Yang, SF, 2015)	3.3
"Quercetin is a kind of antioxidant that has neuroprotective effects and potent7ial pro-oxidant effects as well."	( Differential effects of quercetin on hippocampus-dependent learning and memory in mice fed with different diets related with oxidative stress. Cheng, XR; Le, GW; Li, LR; Qiao, Y; Shi, YH; Tang, X; Xia, SF; Xie, ZX, 2015)	1.45
"Quercetin is a dietary flavonoid which exerts vasodilator, antiplatelet and antiproliferative effects and reduces blood pressure, oxidative status and end-organ damage in humans and animal models of systemic hypertension. "	( The flavonoid quercetin reverses pulmonary hypertension in rats. Barreira, B; Cogolludo, A; Duarte, J; Galindo, P; Jimenez, R; Menendez, C; Moral-Sanz, J; Morales-Cano, D; Moreno, E; Moreno, L; Pandolfi, R; Perez-Vizcaino, F, 2014)	2.21
"Quercetin is a dietary flavonol that has poor and highly variable bioavailability. "	( Endogenous and exogenous mediators of quercetin bioavailability. Bruno, RS; Guo, Y, 2015)	2.13
"Quercetin is a flavonol shown to have anti-carcinogenic actions."	( Dose-dependent benefits of quercetin on tumorigenesis in the C3(1)/SV40Tag transgenic mouse model of breast cancer. Altomare, D; Carson, J; Creek, K; Davis, J; Enos, R; Fayad, R; McClellan, J; Murphy, E; Nagarkatti, M; Nagarkatti, P; Steiner, J, 2014)	1.42
"Quercetin is a polyphenol of growing interest that is present in many foods. "	( Comparison of methods for rapid analysis of quercetin. Lage-Yusty, MA; Lago-Crespo, M; López-Hernández, J; Pardo-Barrela, J, 2015)	2.12
"Quercetin is a flavonol with anti-inflammatory and antioxidant effects and is also an activator of peroxisome proliferator-activated receptor γ coactivator 1α capable of antioxidant upregulation, mitochondrial biogenesis and prevention of cardiac complications."	( Histological and biochemical outcomes of cardiac pathology in mdx mice with dietary quercetin enrichment. Amin, R; Ballmann, C; Hollinger, K; Quindry, JC; Selsby, JT, 2015)	1.36
"Quercetin is a plant flavonoid phytochemical exhibiting a broad spectrum of properties i.a. "	( [Health--promoting effect of quercetin in human diet]. Janas, KM; Kobylińska, A, 2015)	2.15
"Quercetin is a typical flavonoid ubiquitously contained in vegetables and fruits with several biological effects demonstrated in vitro and in vivo including antioxidative, anti-inflammatory, anticancer, and antidiabetic activities."	( Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability. Ishisaka, A; Kawabata, K; Mukai, R, 2015)	2.58
"Quercetin is a natural flavonoid compound that has attracted increased interest and attention due to its anticancer activity."	( Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review). Song, L; Wang, H; Wang, J; Xing, N; Xu, Z; Yang, F, 2015)	2.58
"Quercetin is a promising food component, which can prevent lifestyle related diseases. "	( Estimated daily intake and seasonal food sources of quercetin in Japan. Akasaka, H; Ippoushi, K; Kobori, M; Matsunaga, I; Nagata, T; Naito, S; Nishimuro, H; Ohnishi, H; Ohnishi-Kameyama, M; Oike, H; Saitoh, S; Sato, M; Shimamoto, K, 2015)	2.11
"Quercetin is an antioxidant belongs to flavonoid group."	( Beneficial effects of quercetin on renal injury and oxidative stress caused by ciprofloxacin in rats: A histological and biochemical study. Cetin, A; Dogan, Z; Elbe, H; Taslidere, E; Turkoz, Y, 2016)	1.47
"Quercetin is a dietary flavonoid that exerts anti-metastatic effect in various types of cancer including melanoma."	( Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Cao, HH; Cheng, CY; Fu, XQ; Guo, H; Kwan, HY; Li, T; Su, T; Tse, AK; Yu, H; Yu, ZL, 2015)	2.58
"Quercetin is a plant flavonol that is available from both daily diet and nutraceuticals. "	( The Influence of Single-Dose and Short-Term Administration of Quercetin on the Pharmacokinetics of Midazolam in Humans. Langguth, P; Nguyen, MA; Staubach, P; Wolffram, S, 2015)	2.1
"Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. "	( Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Eo, SK; Lee, JH; Moon, JH; Park, SY, 2015)	3.3
"Quercetin is a bioflavonoid known for antioxidation and antiproliferation activities. "	( Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression. Hur, GY; In, KH; Kang, KH; Kim, JH; Lee, EJ; Lee, SH; Lee, SY; Min, KH; Shim, JJ; Shin, C, 2015)	3.3
"Quercetin is a bioflavonoid with antiproliferative and proapoptotic activity in various cancer cells. "	( Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression. Hur, GY; In, KH; Kang, KH; Kim, JH; Lee, EJ; Lee, SH; Lee, SY; Min, KH; Shim, JJ; Shin, C, 2015)	3.3
"Quercetin (QT) is a potential bioflavonol and antioxidant with poor bioavailability and very low distribution in the brain. "	( Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats. Bagad, M; Khan, ZA, 2015)	2.1
"Quercetin is a classic flavonoid that inhibits the epithelial-mesenchymal transition (EMT) of tumor cells. "	( Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy. Ji, XJ; Liu, YQ; Lu, Q; Yao, XQ; Yin, XX; Zhang, F; Zhou, YX, 2015)	3.3
"Quercetin is a ubiquitous flavonoid present in beverages, food and plants that has been demonstrated to have a role in the prevention of neurodegenerative and cerebrovascular diseases. "	( Quercetin in brain diseases: Potential and limits. Abin-Carriquiry, JA; Arredondo, F; Blasina, F; Dajas, F; Echeverry, C; Martínez, M; Rivera, F; Vaamonde, L, 2015)	3.3
"Quercetin is a competitive inhibitor of MMP-9 and could downregulate the expression of MMP-9 and TGF-β1, which plays an important role in A549 apoptosis."	( [Mechanisms for quercetin in prevention of lung cancer cell growth and metastasis]. Zhang, J; Zhao, X, 2015)	2.21
"Quercetin is a flavonoid found in fruits, vegetables, leaves and grains. "	( The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling. Hwang, JH; Kim, KJ; Lee, BY; Lee, YJ; Seo, MJ, 2015)	2.16
"Quercetin (Que) is a member of flavonoids with anti-oxidant effects."	( Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells. Chen, X; Gao, P; Hu, J; Ji, J; Jiang, Z; Ren, Y; Shao, S; Yan, M; Yu, Q; Zhang, L; Zhao, F, 2015)	1.5
"Quercetin (QUE) is a naturally occurring dietary flavonoid having antioxidant properties."	( Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Maurya, AK; Vinayak, M, 2015)	1.44
"Quercetin is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when administered orally. "	( Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin. Caddeo, C; Carbone, C; Díez-Sales, O; Ennas, G; Fadda, AM; Manconi, M; Pons, R; Puglisi, G, 2016)	2.11
"Quercetin is a dietary flavonoid which exerts anti-oxidant, anti-inflammatory and anti-cancer properties. "	( Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells. Halagowder, D; Ranganathan, S; Sivasithambaram, ND, 2015)	3.3
"Quercetin is a flavonol believed to have beneficial effects on human health. "	( Isolation and characterization of human intestinal Enterococcus avium EFEL009 converting rutin to quercetin. Han, NS; Kim, TJ; Lee, YB; Li, L; Moon, JS; Shin, NR; Shin, SY, 2016)	2.09
"Quercetin is a member of the flavonoids family reported to have better cytoprotective abilities, stronger inhibition of lipopolysaccharide-induced nitric oxide production, and better chemoprevention than rutin. "	( Isolation and characterization of human intestinal Enterococcus avium EFEL009 converting rutin to quercetin. Han, NS; Kim, TJ; Lee, YB; Li, L; Moon, JS; Shin, NR; Shin, SY, 2016)	2.09
"Quercetin is a free radical scavenger and antioxidant."	( Quercetin protection against ciprofloxacin induced liver damage in rats. Cetin, A; Dogan, Z; Elbe, H; Taslidere, E; Turkoz, Y; Vardi, N, 2016)	2.6
"Quercetin is a dietary flavonoid whose role in the regulation of the activity of insulin remains controversial. "	( Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation. Huang, F; Kou, J; Li, J; Liu, B; Liu, K; Mei, F; Qi, LW; Wang, Y; Xiao, N; Yang, L, 2016)	3.32
"Quercetin is a flavonoid compound that widely exists in the nature."	( Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo. Jiang, X; Mei, Z; Song, L; Wang, H; Xing, N; Xu, Z; Yang, F, 2016)	2.6
"Quercetin is a natural plant flavonoid that has been reported to possess a wide range of beneficial health effects, including anti-cancer and anti-inflammatory activities. "	( The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1/MAPK/NF-κB signaling pathway. Choi, JW; Lee, J; Pandey, RP; Park, YI; Sohng, JK, 2016)	2.16
"Quercetin is an important flavonoid that is ubiquitously present in the diet in a variety of fruits and vegetables. "	( Quercetin and the mitochondria: A mechanistic view. Ahmed, T; Braidy, N; de Oliveira, MR; Nabavi, SF; Nabavi, SM; Setzer, WN, )	3.02
"Quercetin is a major constituent of various dietary products and recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in vitro and in vivo."	( Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine. Chakraborty, C; Lee, SS; Nam, JS; Nguyen, LT; Sharma, AR; Sharma, G, 2016)	1.46
"Quercetin (Quer) is a polyphenol present in berries and other commodities which exhibits these effects."	( Role of quercetin on Caco-2 cells against cytotoxic effects of alternariol and alternariol monomethyl ether. Fernández-Blanco, C; Font, G; Ruiz, MJ, 2016)	1.59
"Quercetin (QCT) is a natural flavonoid compound that has attracted increasing interest due to its anticancer activity."	( Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo. Cheng, Q; Duan, X; Huo, S; Liang, XJ; Liu, J; Ma, X; Wei, T; Zhang, C; Zhang, Y; Zhao, J, 2016)	2.6
"Quercetin (QU) is a polyphenol that has an antioxidant effect in vitro, but due to its high lipophilicity, it has low bioavailability in vivo."	( Protective role of free and quercetin-loaded nanoemulsion against damage induced by intracerebral haemorrhage in rats. Antunes, MF; Barros, DM; Cordeiro, MF; Dora, CL; Galho, AR; Hädrich, G; Horn, AP; Lima, JV; Luz, DC; Marques, MS; Muccillo-Baisch, AL; Ribeiro, SA, 2016)	1.45
"Quercetin is a major flavonoid that has anti-oxidant, anti-cancer and anti-inflammatory properties."	( Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons. He, F; Jiang, W; Li, S; Luo, T; Shen, XY; Wang, HQ; Xu, J; Zhou, Y, 2016)	2.6
"Quercetin is a major dietary flavonoid in fruits and vegetables. "	( Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice. Fujikura, Y; Hirasaka, K; Horikawa, M; Hou, DX; Iwasa, K; Kanzaki, N; Matsui, N; Matsumoto, N; Mukai, R; Nikawa, T; Shibata, H; Terao, J, 2016)	2.17
"Quercetin is a flavonoid known for its neuroprotective and antioxidant effects."	( Ameliorative Effect of Quercetin on Neurochemical and Behavioral Deficits in Rotenone Rat Model of Parkinson's Disease: Modulating Autophagy (Quercetin on Experimental Parkinson's Disease). El-Horany, HE; El-Latif, RN; ElBatsh, MM; Emam, MN, 2016)	1.47
"Quercetin (QUE) is a natural flavonol-type flavonoid with antibacterial, anti-inflammatory and anti-aggregatory properties. "	( Protective Effects of Quercetin on Selected Oxidative Biomarkers in Bovine Spermatozoa Subjected to Ferrous Ascorbate. Kováčik, A; Libová, Ľ; Lukáč, N; Paál, D; Tušimová, E; Tvrdá, E, 2016)	2.19
"Quercetin is a plant flavonoid having hepatoprotective and antioxidative potential and the ability to reduce liver lipid accumulation in monogastric animals."	( Effects of a six-week intraduodenal supplementation with quercetin on liver lipid metabolism and oxidative stress in peripartal dairy cows. Esatbeyoglu, T; Metges, CC; Mielenz, M; Nürnberg, G; Rimbach, G; Sauerwein, H; Starke, A; Stoldt, AK; Wagner, AE; Wolffram, S, 2016)	1.4
"Quercetin (QT) is a natural flavonoid with various biological activities and pharmacological actions. "	( Development of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats. Chen, X; Gu, L; Hu, G; Jia, J; Liu, Z; Zhang, K; Zhang, M; Zhang, Y, 2016)	2.23
"Quercetin is a natural compound that has several biological activities including anticancer activity. "	( Oral Delivery of a High Quercetin Payload Nanosized Emulsion: In Vitro and In Vivo Activity Against B16-F10 Melanoma. Assreuy, J; Baischl, AL; Dora, CL; Fernandes, D; Lemos-Senna, E; Maioral, MF; Mazzarino, L; Pacheco, LK; Santos-Silva, MC; Silva, LF; Siqueira, JM, 2016)	2.18
"Quercetin is a flavonoid reported as anti-allergic, anti-inflammatory, antiplatelet, anti-microbial, antioxidant, antineurodegenerative and antitumoral. "	( Bovine Serum Albumin Nanoparticles Containing Quercetin: Characterization and Antioxidant Activity. Antônio, E; Khalil, NM; Mainardes, RM, 2016)	2.14
"Quercetin (Quer) is a naturally occurring flavonol present in many commonly consumed food items."	( Molecular mechanisms of action of quercetin in cancer: recent advances. Kashyap, D; Mittal, S; Sak, K; Singhal, P; Tuli, HS, 2016)	1.43
"Quercetin is an important dietary flavonoid present in fruits and vegetables and has attracted attention because of its anti-inflammatory and anti-oxidative properties. "	( Protective Effect of Quercetin on Posttraumatic Cardiac Injury. Bi, Y; Cao, T; Chen, X; Jing, Z; Li, S; Li, X; Wang, Z; Yu, D; Zhou, J; Zhu, L, 2016)	2.2
"Quercetin is a known antioxidant and protein kinase C (PKC) inhibitor. "	( Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice. Acco, A; Andreatini, R; Barcaro, IMR; Dos Reis Lívero, FA; Hocayen, PAS; Kanazawa, LKS; Stipp, MC; Vecchia, DD; Wendler, EM, 2016)	3.32
"Quercetin is a flavonoid occurring in many plant foods commonly consumed as part of a regular diet."	( Neuroprotective Effects of Quercetin: From Chemistry to Medicine. Barreca, D; Bellocco, E; D'Onofrio, G; Daglia, M; Nabavi, SF; Nabavi, SM; Rastrelli, L, 2016)	1.45
"Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. "	( Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets. Bartosch, B; Bautista, JD; Clement, S; Del Campo, JA; García-Valdecasas, M; Gil-Gómez, A; Lemasson, M; Negro, F; Ranchal, I; Rojas, Á; Romero-Gómez, M; Rosenberg, AR, 2016)	2.28
"Quercetin is a flavonoid with very pronounced effective antioxidant and antiinflammatory activities, and thus a candidate of first choice for such skin supplementation."	( Quercetin topical application, from conventional dosage forms to nanodosage forms. Bégu, S; Devoisselle, JM; Hatahet, T; Hommoss, A; Morille, M; Müller, RH, 2016)	2.6
"Quercetin (QR), is a polyphenolic flavonoid compound which is found in large amounts in certain foods, and protects against oxidative stress. "	( Hepatoprotective effect of Quercetin supplementation against Acrylamide-induced DNA damage in wistar rats. Abudawood, M; Ansar, S; Ganaie, MA; Siddiqi, NJ; Zargar, S, 2016)	2.17
"Quercetin is a potent cancer therapeutic agent presented in fruit and vegetables, preventing tumor proliferation, and is a well known cancer therapeutic agent and autophagy mediator."	( Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo. Feng, FQ; Ji, PG; Li, BF; Liu, JH; Lou, M; Wang, L; Yang, C; Zhang, LN, 2016)	2.6
"Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits."	( Role of Quercetin Benefits in Neurodegeneration. Elumalai, P; Lakshmi, S, 2016)	1.59
"Quercetin (Que) is an abundant flavonoid in the human diet and high-concentration food supplement with reported pro- and anti-carcinogenic activities. "	( Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements. Aqaqe, N; Biechonski, S; Elad, D; Gourevich, D; Grisaru, D; Jaffa, AJ; Milyavsky, M; Olender, L; Rall, M; Raz, Y; Trakhtenbrot, L; Wiesmuller, L; Yassin, M; Zipin-Roitman, A, 2017)	3.34
"Quercetin is considered to be an anti-oxidant with healing effects on many experimental toxic injuries."	( Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats. Alkushi, AGR; Elsawy, NAM, 2017)	2.62
"Quercetin is a major dietary flavonoid found in a various fruits, vegetables, and grains. "	( Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability. Han, YH; Hong, SH; Jeong, MY; Kee, JY; Kim, DS; Mun, JG; Park, J; Um, JY, 2016)	2.2
"Quercetin is a naturally occurring compound with strong antioxidant action and can successfully scavenge free radicals."	( Protective effects of quercetin on UVB irradiation‑induced cytotoxicity through ROS clearance in keratinocyte cells. Chen, H; Ding, L; Li, N; Shi, X; Wang, Y; Yu, Y; Zhu, X, 2017)	1.49
"Quercetin is a flavonol which inhibits some virus infectivity and replication."	( Biophysical characterization of the interaction between M2-1 protein of hRSV and quercetin. Caruso, ÍP; Fossey, MA; Lopes, BR; Regasini, LO; Souza, FP; Teixeira, TS; Toledo, KA, 2017)	1.4
"Quercetin (QCT) is a dietary flavonoid and has been demonstrated to be antifungal against C."	( Quercetin Assists Fluconazole to Inhibit Biofilm Formations of Fluconazole-Resistant Candida Albicans in In Vitro and In Vivo Antifungal Managements of Vulvovaginal Candidiasis. Gao, M; Wang, H; Zhu, L, 2016)	2.6
"Quercetin is a dietary flavonoid compound extracted from various plants, such as apple and onions. "	( Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway. Lu, XL; Yao, XL; Zhang, H; Zhao, CH, 2017)	3.34
"Quercetin (Q) is a bioactive flavonol with potential to benefit human health. "	( Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro. Arca, HC; Edgar, KJ; Gilley, AD; Mosquera-Giraldo, LI; Neilson, AP; Nichols, BLB; Taylor, LS, 2017)	2.14
"Quercetin is an anti‑diabetic and cardiovascular protective agent that has previously been demonstrated to reduce ER stress in human umbilical vein endothelial cells (HUVECs)."	( Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine. Bao, L; Cai, X; Dai, X; Ding, Y; Li, Y; Zhang, Z, 2017)	2.62
"Quercetin is a polyphenol, which is a derivative of plants, and has been shown"	( Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 Diabetes. Chen, S; Fang, J; Jiang, H; Wu, X, 2016)	1.47
"Quercetin is a plant flavonoid with strong antioxidant and antiinflammatory properties interesting for skin protection. "	( Dermal quercetin lipid nanocapsules: Influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide. Aubert-Pouëssel, A; Bégu, S; Devoisselle, JM; Hatahet, T; Morille, M; Shamseddin, A, 2017)	2.35
"Quercetin is a dietary antioxidant."	( Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1. Lv, H; Pan, F; Pei, C; Zhu, L, 2016)	2.6
"Quercetin is a common flavonol that has been shown to have potent antioxidant, anti-inflammatory, and anti-fibrotic activities both in vitro and in vivo in various tissues."	( Quercetin and the ocular surface: What we know and where we are going. Karamichos, D; McKay, TB, 2017)	2.62
"Quercetin is an ubiquitous bioactive antioxidant rich in vegetables and beverages."	( Quercetin Attenuates Cell Survival, Inflammation, and Angiogenesis via Modulation of AKT Signaling in Murine T-Cell Lymphoma. Maurya, AK; Vinayak, M, 2017)	2.62
"Quercetin is a bioactive compound exerting therapeutic effects on in vivo animal models of neurodegeneration or neurotoxicity. "	( Quercetin-3-O-glucuronide promotes the proliferation and migration of neural stem cells. Baral, S; Kim, J; Lee, HS; Pariyar, R; Seo, J, 2017)	3.34
"Quercetin is a flavonoid with antifibrotic, and hepatoprotective properties."	( Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats. Eskandari-Nasab, E; Ghoreshi, ZA; Kabirifar, R; Karimollah, A; Moradi, A; Safari, F, 2017)	2.62
"Quercetin is a dietary flavonoid which has anti-inflammatory effects. "	( Effects of Quercetin Treatment on Epithelium-derived Cytokines and Epithelial Cell Apoptosis in Allergic Airway Inflammation Mice Model. Anal, O; Arikan Ayyildiz, Z; Bagriyanik, A; Caglayan Sozmen, S; Cilaker Micili, S; Isik, S; Karaman, M; Karaman, O; Uzuner, N, 2016)	2.27
"Quercetin (Q) is a flavonoid widely distributed in the plant kingdom and well-known for its ability to exert antioxidant, prooxidant and anticarcinogenic activities in several tumor cells. "	( Quercetin derivatives as potent inducers of selective cytotoxicity in glioma cells. Dell'Albani, P; Di Marco, B; Foti, MC; Grasso, S; Rocco, C, 2017)	3.34
"Quercetin is a well-known flavonoid, has pharmacokinetic interaction with ester drugs due to its capability of esterase inhibition in the gut and liver. "	( Enhancement of oral bioavailability of rivastigmine with quercetin nanoparticles by inhibiting CYP3A4 and esterases. Neerati, P; Palle, S, 2017)	2.14
"Quercetin is a major component of the plant Glycyrrhiza uralensis, which is largely used as a traditional medicine in Asia. "	( The anti-HSV-1 effect of quercetin is dependent on the suppression of TLR-3 in Raw 264.7 cells. Cho, H; Kang, H; Lee, HH; Lee, S; Shin, YS, 2017)	2.2
"Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. "	( Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells. Han, XW; Li, YH; Li, ZM; Lu, HB; Ren, JZ; Ren, KW; Wu, G, 2017)	3.34
"Quercetin is a potent antioxidant compound."	( Protective Effect of Quercetin Against Oxidative Stress-induced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue. Dogan, Z; Erdemli, E; Kocahan, S; Taskin, E, 2017)	1.5
"Quercetin is a most promising compound for disease prevention and therapy; however, many of the effects still need confirmation by human intervention trials."	( Quercetin: potentials in the prevention and therapy of disease. Bischoff, SC, 2008)	3.23
"Quercetin is a flavonoid found ubiquitously in nature. "	( Quercetin is able to demethylate the p16INK4a gene promoter. Cui, Y; Lu, C; Ma, X; Shi, X; Tan, S; Wang, C; Zhao, B, 2009)	3.24
"Quercetin is a herbal flavonoid derived from various foods of plant origin and widely used as a major constituent of nutritional supplements. "	( Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways. Chen, L; Cheng, D; Fan, H; Hu, X; Liu, D; Lu, X; Song, X; Wang, T; Wei, Y; Wen, F; Xu, D; Yang, T; Ying, B, 2009)	3.24
"Quercetin is a flavonoid present in many vegetables, fruits, and beverages. "	( Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. An, JY; Jeong, JH; Kwon, YT; Lee, YJ; Rhee, JG, 2009)	2.12
"Quercetin is a natural flavonoid with many important therapeutic properties. "	( Fluorescence quenching study of quercetin interaction with bovine milk xanthine oxidase. Jabary, HN; Naseri, A; Rashidi, MR; Rasoulzadeh, F, 2009)	2.08
"Quercetin is a natural flavonoid with pro-apoptotic and antiproliferative properties. "	( Different sensitivity of neurons and neuroblastoma cells to quercetin treatment. Gawron, A; Glowniak, K; Jakubowicz-Gil, J; Piersiak, T; Rzeski, W; Weiksza, K; Zdzisińska, B, 2008)	2.03
"Quercetin is a flavonoid with anti-carcinogenic and antioxidant properties."	( Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism. Aparicio-Rautista, DI; Arellanes-Robledo, J; García-Román, R; Vásquez-Garzón, VR; Villa-Treviño, S, 2009)	1.31
"Quercetin (Qu) is a dietary flavonoid and a known inhibitor of PI3K."	( Stabilization of quercetin paradoxically reduces its proapoptotic effect on UVB-irradiated human keratinocytes. Bowden, GT; Dong, Z; Melton, T; Olson, ER, 2008)	1.41
"Quercetin is a well-investigated antioxidant known to protect cells against oxidative nuclear DNA damage. "	( Effect of quercetin on oxidative nuclear and mitochondrial DNA damage. Calcabrini, C; Cucchiarini, L; Dachà, M; De Bellis, R; Mancini, U; Potenza, L, 2008)	2.19
"Quercetin is a major dietary flavonoid found in onions and other vegetables, and potentially has beneficial effects on disease prevention. "	( Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice. Inakuma, T; Kato, S; Kawai, Y; Mizuha, Y; Sato, T; Takeda, E; Taketani, Y; Terao, J; Tsuji, M; Yamamoto, H, 2009)	2.23
"Quercetin is a food component that may ameliorate the diabetic symptoms. "	( Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice. Akimoto, Y; Kobori, M; Masumoto, S; Takahashi, Y, 2009)	2.23
"Quercetin is a flavonoid of interest because of its proposed health-promoting effects."	( The flavonoid quercetin protects and prevents against potassium dichromate-induced systemic peroxidation of lipids and diminution in renal clearance of para-aminohippuric acid and inulin in the rat. Becerra-Torres, SL; Jaramillo-Juárez, F; Medina-Ramírez, IE; Rodríguez-Vázquez, ML, 2009)	1.43
"Quercetin (QC) is a poorly water-soluble and degradation-prone bioflavonoid."	( Production and characterization of a spray-dried hydroxypropyl-beta-cyclodextrin/quercetin complex. Chow, AH; Zheng, Y, 2009)	2.02
"Quercetin is a major natural polyphenol that is known to protect cells from UVA-induced damage."	( Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Ishii, T; Ishii, Y; Itoh, K; Kawachi, Y; Kimura, S; Ma, D; Warabi, E; Yanagawa, T, 2009)	1.31
"Quercetin is a flavonoid compound found in a number of medicinal plants that are often prescribed in Chinese clinics for the treatment of cardiovascular diseases. "	( Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons. Han, DD; Yang, Z; Yao, Y; Zhang, T, 2010)	3.25
"Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. "	( Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Kroon, PA; Mithen, RF; Radreau, P; Rhodes, JD; Sanderson, J, 2009)	2.04
"Quercetin is a bioflavonoid abundant in onions, apples, tea and red wine and one of the most studied flavonoids. "	( Flavonoid quercetin protects against swimming stress-induced changes in oxidative biomarkers in the hypothalamus of rats. Haleagrahara, N; Kumar, P; Lee, N; Radhakrishnan, A, 2009)	2.2
"Quercetin is a plant-derived flavonoid widely known by its anti-oxidant and anti-inflammatory properties, but its oral bioavailability is very poor and this becomes difficult to assess its therapeutic potential. "	( Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Andrade, EL; Calixto, JB; Chaves, JS; Dora, CL; Lemos-Senna, E; Rogerio, AP; Silva, LF, 2010)	2.1
"Quercetin is a flavonoid found in many foods including apples, onions and tea."	( Inhibitory effect of quercetin on periodontal pathogens in vitro. Geoghegan, F; Rabie, AB; Wong, RW, 2010)	1.4
"Quercetin is a major flavonoid that contributes to the reduced risk of cardiovascular disease associated with dietary ingestion of fruits and vegetables. "	( Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Hughes, DA; Kroon, PA; Liu, XH; Needs, PW; Rayment, S; Suri, S; Taylor, MA; Tribolo, S; Wilson, VG, 2010)	3.25
"Quercetin is a naturally occurring flavonoid with anti-oxidant and anti-inflammatory properties. "	( Effect of quercetin supplementation on maximal oxygen uptake in men and women. Armstrong, LE; Ballard, KD; Ganio, MS; Johnson, EC; Kaushik, D; Klau, JF; Maresh, CM; Michniak-Kohn, B, 2010)	2.21
"Quercetin (QR) is a strong antioxidant and has been shown to reduce oxidative stress in the long-term treatment of streptozotocin (STZ)-induced diabetes in animal models. "	( Beneficial effects of quercetin on sperm parameters in streptozotocin-induced diabetic male rats. Ahmadi, P; Fathiazad, F; Khaki, A; Khamnei, HJ; Maleki, NA; Nouri, M, 2010)	2.12
"Quercetin is a potent antioxidant and has been extensively used as a therapy intervention to prevent age-associated diseases. "	( Quercetin-induced H(2)O(2) mediates the pathogen resistance against Pseudomonas syringae pv. Tomato DC3000 in Arabidopsis thaliana. Dong, H; Gou, Z; Jia, Z; Ma, H; Qiu, J; Song, S; Wang, X; Zou, B, 2010)	3.25
"Quercetin is a bioflavonoid reported to produce variety of behavioral effects like anxiolytic, antidepressant, etc. "	( Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice. Bansod, K; Bhutada, P; Mundhada, D; Mundhada, Y; Quazi, M; Ubgade, A; Umathe, S, 2010)	2.18
"Quercetin is a naturally occurring dietary flavonol and several reports have shown that quercetin substantially affects cognitive function in disease models, which suggests that quercetin might be a useful agent for treatment of memory dysfunction. "	( Quercetin impairs learning and memory in normal mice via suppression of hippocampal phosphorylated cyclic AMP response element-binding protein expression. Jung, WY; Kim, DH; Kim, JM; Park, DH; Park, SJ; Ryu, JH, 2010)	3.25
"Quercetin is a potential chemopreventive and chemotherapeutic agent for pancreatic and other cancers. "	( Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts. Angst, E; Dawson, DW; Eibl, G; Go, VL; Hines, OJ; Lu, QY; Moro, A; Park, JL; Reber, HA; Zhang, L, 2010)	3.25
"Quercetin is an excellent antioxidant that has a variety of side effects. "	( Quercetin accumulation by chronic administration causes the caspase-3 activation in liver and brain of mice. Choi, EJ; Kim, GH, )	3.02
"Quercetin is a plant derived flavonoid and popular nutritional supplement proposed to prevent memory loss and altitude sickness among other ailments, although its precise mechanism(s) of action has been unclear. "	( Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission. Braun, JE; Gibbs, S; Johnson, JN; Proft, J; Syed, N; Winkfein, B; Xu, F, 2010)	3.25
"Quercetin is a plant-derived bioflavonoid with potentially beneficial effects on the cardiovascular system. "	( Acute treatment with polyphenol quercetin improves postischemic recovery of isolated perfused rat hearts after global ischemia. Barteková, M; Breier, A; Carnická, S; Ondrejcáková, M; Pancza, D; Ravingerová, T, 2010)	2.09
"Quercetin is a unique dietary polyphenol because it can exert biphasic dose-responses on cells depending on its concentration. "	( Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. Burd, R; Vargas, AJ, 2010)	2.06
"Quercetin is a flavonoid naturally present in food and beverages belonging to the large class of phytochemicals with potential anti-cancer properties. "	( Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients. Mupo, A; Russo, GL; Russo, M; Spagnuolo, C; Tedesco, I; Volpe, S, 2010)	3.25
"Quercetin is a low molecular weight flavonoid found in dietary fruits and vegetables. "	( Effects of quercetin on human α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated ion currents. Choi, SH; Han, YS; Hwang, SH; Kim, BR; Kim, HC; Lee, BH; Lee, JH; Lee, SM; Nah, SY; Park, JH; Pyo, MK; Rhim, H; Shin, TJ, 2010)	2.19
"Quercetin is a useful therapeutic agent for the treatment of colitis and gastric ulcer."	( Management of aphthous ulceration with topical quercetin: a randomized clinical trial. Hamdy, AA; Ibrahem, MA, 2010)	1.34
"Quercetin is a safe, well-tolerated, and highly effective promising new, adjunctive treatment for healing common aphthous ulcers."	( Management of aphthous ulceration with topical quercetin: a randomized clinical trial. Hamdy, AA; Ibrahem, MA, 2010)	2.06
"Quercetin is a flavonoid with anticancer properties. "	( The flavonoid quercetin transiently inhibits the activity of taxol and nocodazole through interference with the cell cycle. Fadlalla, K; Samuel, T; Turner, T; Yehualaeshet, TE, 2010)	2.16
"Quercetin is a flavonoid with a wide variety of cytoprotective and modulatory functions. "	( Attenuation of transforming growth factor-β-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1. Hasegawa, Y; Hashimoto, N; Hayashi, Y; Imaizumi, K; Kawabe, T; Matsushima, M; Nakamura, T; Shibasaki, M; Shimokata, K, 2011)	2.03
"Quercetin is an antioxidant flavonoid, found ubiquitously in nature and extensively used in herbal medicines and food additives. "	( Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats. Gupta, C; Jena, GB; Ramarao, P; Tripathi, DN; Vikram, A, 2011)	3.25
"Quercetin is a potent dietary antioxidant that also displays anti-inflammatory activities."	( Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Bast, A; Boots, AW; de Boer, VC; Drent, M; Haenen, GR, 2011)	2.53
"Quercetin is a flavonoid found in plant foods and herbal medicines. "	( Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria. Hara, A; Ishisaka, A; Kawabata, K; Kawai, Y; Sakakibara, H; Terao, J; Tokumura, A; Yoshino, S, )	1.98
"Quercetin acts as an anti-oxidant to protect retinal pigment epithelial cells (RPE) from damaged by oxidative stress, but its effect on formation of choroidal neovascularization (CNV) in AMD is unclear."	( Effect of quercetin on formation of choroidal neovascularization (CNV) in age-related macular degeneration(AMD). Chiou, GC; Lin, BQ; Shen, Y; Zhang, WY; Zhuang, P, 2011)	1.49
"Quercetin (Que) is a flavonoid widely distributed in vegetables and fruits and exhibits strong antioxidant activity, but the poor stability of Que limits its function and application. "	( Bovine serum albumin nanoparticle promotes the stability of quercetin in simulated intestinal fluid. Fang, R; Hao, R; Jing, H; Leng, X; Li, Q; Wu, X, 2011)	2.05
"Quercetin, a flavonoid, is an inhibitor of P-glycoprotein-mediated efflux transport, and its oxidative metabolism is catalyzed by CYP enzymes. "	( Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin. Choi, JS; Kang, KW; Piao, YJ, 2011)	2.2
"Quercetin is a dietary flavonoid purported to improve human endurance exercise capacity. "	( Quercetin and endurance exercise capacity: a systematic review and meta-analysis. Kressler, J; Millard-Stafford, M; Warren, GL, 2011)	3.25
"Quercetin is a flavonoids that recently has raised many issues and shown evidence about its action as a potential drug to allergy."	( Quercetin as a potential anti-allergic drug: which perspectives? Chirumbolo, S, 2011)	2.53
"Quercetin, a flavonoid is a safe and potent neuroprotective antioxidant."	( Polychlorinated biphenyl (PCBs)-induced oxidative stress plays a critical role on cerebellar dopaminergic receptor expression: ameliorative role of quercetin. Arunakaran, J; Bavithra, S; Krishnamoorthy, G; Pratheepa Kumari, R; Selvakumar, K; Venkataraman, P, 2012)	1.3
"Quercetin is a ubiquitous plant-derived flavonoid with well documented anti-inflammatory properties, in part, a consequence of its capacity to downmodulate the NF-κB signal transduction pathway."	( Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts. Weitzmann, MN; Yamaguchi, M, 2011)	2.53
"Quercetin is a typical anti-oxidative flavonoid ubiquitously distributed in vegetables. "	( Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo. Kawai, Y; Murota, K; Terao, J, 2011)	2.2
"Quercetin is a major flavonoid in the human diet and the most commonly used in studies of biological activity. "	( Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans. Cabello, J; Dueñas, M; Gómez-Orte, E; González-Manzano, S; González-Paramás, AM; Santos-Buelga, C; Surco-Laos, F, 2011)	2.08
"Quercetin is a flavonol modifying a number of cell processes in different cell lines. "	( Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells. Alexaki, VI; Castanas, E; Kampa, M; Nifli, AP; Notas, G; Pelekanou, V; Theodoropoulos, P; Vercauteren, J, 2012)	3.26
"Quercetin is a major flavonoid that is found in most plants; it can intercalate with DNA. "	( 125I-labeled quercetin as a novel DNA-targeted radiotracer. Hosseinimehr, SJ; Stenerlöw, B; Tolmachev, V, 2011)	2.18
"Quercetin is an active constituent of Hippophae rhamnoides L. "	( Modulatory effects of quercetin on hypobaric hypoxic rats. Gao, Y; Zeng, S; Zhou, J; Zhou, S, 2012)	2.14
"Quercetin is a mixed inhibitor, whereas quercitrin and isoquercitrin are uncompetitive inhibitors of L."	( The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase. da Silva, ER; Magalhães, PP; Maquiaveli, Cdo C, 2012)	1.39
"Quercetin is a proven antioxidant that might have decreased the oxidative stress produced by chronic alcoholism."	( Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Bodhankar, SL; Ghosh, P; Ghule, AE; Kandhare, AD; Raygude, KS, 2012)	1.37
"Quercetin is a flavonol that appears to be protective against several cancers, but its possible role in prevention of colorectal cancer is not yet well studied. "	( Association of dietary quercetin with reduced risk of proximal colon cancer. Djuric, Z; Kato, I; Severson, RK, 2012)	2.13
"Quercetin is a natural compound that has shown several biological activities. "	( Poly(ethylene glycol) hydroxystearate-based nanosized emulsions: effect of surfactant concentration on their formation and ability to solubilize quercetin. Borsali, R; Dora, CL; Lemos-Senna, E; Nishiyama, Y; Pignot-Paintrand, I; Putaux, JL; Silva, LF, 2012)	2.02
"Quercetin is a popular flavonoid in plant foods, herbs, and dietary supplement. "	( Hydroxyl radical scavenging mechanism of human erythrocytes by quercetin-germanium (IV) complex. Cai, HH; Cai, JY; Li, SP; Xie, WL; Yang, PH, 2012)	2.06
"Quercetin (QU) is a potent anti-inflammatory agent; however, its poor water solubility restricts its clinical application."	( Treating acute cystitis with biodegradable micelle-encapsulated quercetin. Gao, X; Gou, ML; Huang, MJ; Huang, N; Men, K; Qian, ZY; Qiu, J; Wang, BL; Wei, YQ; Yang, B; Zhao, X, 2012)	1.34
"Quercetin is a P-gp inhibitor and may be an inhibitor of CYP3A4."	( Pharmacokinetic interaction study between quercetin and valsartan in rats and in vitro models. Babu, PR; Challa, SR; Challa, VR; Johnson, B; Maheswari, C, 2013)	1.38
"Quercetin is a potent anti-inflammatory flavonoid, but its capacity to modulate insulin sensitivity in obese insulin resistant conditions is unknown. "	( Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes. Anhê, FF; Anhê, GF; Bordin, S; Hirabara, SM; Kinote, A; Lellis-Santos, C; Lima, GA; Machado, UF; Okamoto, MM; Sollon, C; Velloso, LA, 2012)	3.26
"Quercetin is a plant-derived flavonoid known to possess anti-inflammatory property, but its use as a chemopreventive substance has been reviewed quite recently. "	( Quercetin in cancer prevention and therapy. Chirumbolo, S, 2013)	3.28
"Quercetin was observed to be a more potent antioxidative and anti-inflammatory agent."	( Quercetin as a prophylactic measure against high altitude cerebral edema. Bansal, A; Mathew, T; Patir, H; Sarada, SK; Singh, B; Singh, S, 2012)	2.54
"Quercetin is an inhibitor of CYP3A4 and P-gp."	( Influence of quercetin on the pharmacokinetics of ranolazine in rats and in vitro models. Babu, KN; Babu, PJ; Babu, PR; Peter, PL; Rajesh, K, 2013)	1.48
"Quercetin is a ubiquitous flavonoid that is present in numerous plants that are utilized in many different cultures for their nervous system and anticancer effects. "	( Life or death: neuroprotective and anticancer effects of quercetin. Dajas, F, 2012)	2.07
"Quercetin is a bioflavonoid that exhibits several biological functions in vitro and in vivo. "	( Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway. Chen, CY; Hsu, HY; Huang, LH; Li, CJ; Lin, CN; Tsai, CH; Tseng, HL, 2012)	3.26
"Quercetin is a major flavonoid in a wide range of fruits and vegetables. "	( Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK. Croft, KD; Hodgson, JM; Kyle, R; Lee, IL; Shen, Y; Stocker, R; Wang, Y; Ward, NC, 2012)	3.26
"Quercetin (Q) is a bioactive compound with excellent antioxidant activity. "	( Competition between ascorbate and glutathione for the oxidized form of methylated quercetin metabolites and analogues: tamarixetin, 4'O-methylquercetin, has the lowest thiol reactivity. Bast, A; Haenen, GR; Moalin, M; van Strijdonck, GP, 2012)	2.05
"Quercetin is a well known aglycone flavonoid that is widely found in different food sources."	( Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain. Habtemariam, S; Latifi, AM; Mirzaei, M; Moghaddam, AH; Nabavi, SF; Nabavi, SM, 2012)	2.15
"Quercetin is a naturally occurring flavonoid that is known to form complexes with metals; a process that reduces the environmental availability of toxic metals such as chromium. "	( Reduction of hexavalent chromium using naturally-derived flavonoids. Chong, J; Doetschman, D; Knipfing, MT; Mwilu, S; Noah, N; Okello, VA; Sadik, OA; Zhou, A, 2012)	1.82
"Quercetin is a member of the flavonoid family and has been previously shown to have a variety of anti-cancer activities. "	( Rapid dimerization of quercetin through an oxidative mechanism in the presence of serum albumin decreases its ability to induce cytotoxicity in MDA-MB-231 cells. Bortolazzo, A; Pham, A; White, JB, 2012)	2.14
"Quercetin is a naturally occurring flavonol with antioxidant, anticancer and anti-ageing properties. "	( Quercetin protects Saccharomyces cerevisiae against oxidative stress by inducing trehalose biosynthesis and the cell wall integrity pathway. Amorim, MA; Carreto, L; Costa, V; de Freitas, V; Mateus, N; Mendes, MV; Mendes, V; Moradas-Ferreira, P; Vilaça, R, 2012)	3.26
"Quercetin (QU) is a hydrophobic agent with potential anticancer activity."	( Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Gao, X; Gou, M; Guo, G; Huang, M; Huang, N; Men, K; Qian, Z; Wang, B; Wei, X; Wei, Y; Zheng, F; Zheng, Y; Zhou, Y, 2012)	1.34
"Quercetin is a natural flavonoid possessing a number of health beneficial effects. "	( Vitamin C inhibits staphylococcus aureus growth and enhances the inhibitory effect of quercetin on growth of Escherichia coli in vitro. Jaakkola, M; Kallio, J; Kilpeläinen, P; Mäki, M; Virtanen, V, 2012)	2.04
"Quercetin is a well-known antioxidant. "	( Quercetin improves baroreflex sensitivity in spontaneously hypertensive rats. Alves, NF; Braga, VA; França-Silva, MS; Monteiro, MM; Porpino, SK, 2012)	3.26
"Quercetin is a natural flavonoid that has been shown to have the highest anti-radical activity, along with the ability to act as a scavenger of free radicals and an inhibitor of lipid peroxidation."	( Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems. Bose, S; Du, Y; Michniak-Kohn, B; Takhistov, P, 2013)	1.37
"Quercetin is an abundant micronutrient in our daily diet. "	( Inhibition of mTOR signaling by quercetin in cancer treatment and prevention. Bruning, A, 2013)	2.12
"Quercetin (1) is an anti-inflammatory and antioxidant flavonoid. "	( Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanisms. Baracat, MM; Casagrande, R; Colombo, BB; Fattori, V; Georgetti, SR; Guazelli, CF; Verri, WA; Vicentini, FT, 2013)	3.28
"Quercetin is a plant-derived flavonoid found in fruits or vegetables that has antioxidant properties and acts as a free radical scavenger. "	( Quercetin improves the in vitro development of porcine oocytes by decreasing reactive oxygen species levels. Jang, G; Kang, JT; Kim, SJ; Koo, OJ; Kwon, DK; Lee, BC; Moon, JH; Park, SJ, 2013)	3.28
"Quercetin is an inhibitor of CYP3A4 and a modulator of Pgp."	( Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Chao, PD; Hou, YC; Hsiu, SL; Su, SF; Tsao, CW; Wang, YH, 2002)	2.48
"Quercetin is a potent inhibitor of apomorphine sulfation and may inhibit the sulfation of apomorphine in human brain in vivo."	( Quercetin inhibits the sulfation of r(-)-apomorphine in human brain. Cantini, R; Pacifici, GM; Vaglini, F; Vietri, M, 2003)	2.48
"Quercetin is a naturally occurring L-type Ca(2+) channel agonist. "	( Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena. Fusi, F; Gorelli, B; Pessina, F; Saponara, S; Sgaragli, G, 2003)	2.15
"Quercetin is a flavonoid molecule ubiquitous in nature and functions as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. "	( Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage. Bok, SH; Cho, SY; Choi, WY; Do, SH; Jeong, KS; Jeong, TS; Jeong, WI; Kwon, MJ; Lee, CS; Park, SJ; Ryu, SY; Song, JC, 2003)	3.2
"Quercetin is a bioflavonoid with strong antioxidant properties."	( Reversal of haloperidol-induced orofacial dyskinesia by quercetin, a bioflavonoid. Kulkarni, SK; Naidu, PS; Singh, A, 2003)	1.29
"Quercetin is a naturally occurring flavonoid that exerts multiple pharmacological effects. "	( The study of the quercetin action on human erythrocyte membranes. Gawron, A; Gruszecki, WI; Misiak, LE; Pawlikowska-Pawlega, B, 2003)	2.1
"Quercetin is a typical flavonoid ubiquitously present in fruits and vegetables, and its antioxidant effect is implied to be helpful for human health. "	( Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Murota, K; Terao, J, 2003)	2.07
"Quercetin is a bioflavonoid with strong antioxidant properties."	( Reversal of reserpine-induced orofacial dyskinesia and cognitive dysfunction by quercetin. Kulkarni, SK; Naidu, PS; Singh, A, 2004)	1.27
"Quercetin is an ubiquitous antioxidant flavonoid."	( Lethal quercetin-digoxin interaction in pigs. Chao, PD; Hou, YC; Hsiu, SL; Wang, YH; Wen, KC, 2004)	1.5
"Quercetin is a bioflavonoid with strong antioxidant properties."	( Reversal of aging and chronic ethanol-induced cognitive dysfunction by quercetin a bioflavonoid. Kulkarni, SK; Naidu, PS; Singh, A, 2003)	1.27
"Quercetin is a typical antioxidative flavonoid found in vegetables, which is more commonly present as its glucosides, quercetin-3-glucoside (Q3G) and quercetin-4'-glucoside (Q4'G). "	( Quercetin-4'-glucoside is more potent than quercetin-3-glucoside in protection of rat intestinal mucosa homogenates against iron ion-induced lipid peroxidation. Ichikawa, M; Mitsukuni, Y; Miyamoto, S; Murota, K; Terao, J; Tsushida, T, 2004)	3.21
"Quercetin is an important dietary flavonoid with putative beneficial effects in the prevention of cancer and CVD. "	( The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Arts, IC; Faassen-Peters, M; Hollman, PC; Sesink, AL, 2004)	1.97
"Quercetin is a major dietary flavonoid consumed with a diet rich in onions, tea, and apples."	( Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Daniel, H; Herzog, A; Kuntz, S; Wenzel, U, 2004)	1.29
"Quercetin is a flavonoid that can inhibit proliferation of tumor cells and reduce the number of aberrant crypt foci, although increase of number of colon tumors was also reported."	( Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Aarts, JM; Roepman, P; Stierum, RH; van Bladeren, PJ; van der Lende, TR; van Erk, MJ; van Ommen, B, 2005)	1.29
"Quercetin is a dietary anticancer chemical that is capable of inducing apoptosis in tumor cells. "	( Selective effects of quercetin on the cell growth and antioxidant defense system in normal versus transformed mouse hepatic cell lines. Jang, YS; Jeon, YM; Kim, JG; Kook, SH; Lee, JC; Lee, KY; Son, YO, 2004)	2.09
"Quercetin is an important dietary flavonoid with in vitro antioxidant activity. "	( Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin. Janisch, KM; Needs, P; Plumb, GW; Williamson, G, 2004)	2.13
"Quercetin is a common antioxidant flavonoid found in vegetables, which is usually present in glycosylated forms, such as quercitrin (3-rhamnosylquercetin). "	( In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway. Ballester, I; Camuesco, D; Comalada, M; Gálvez, J; Sierra, S; Xaus, J; Zarzuelo, A, 2005)	2.01
"Quercetin is a bioactive flavonoid widely used as a health supplement. "	( Physicochemical and structural characterization of quercetin-beta-cyclodextrin complexes. Chow, AH; Chow, MS; Haworth, IS; Zheng, Y; Zuo, Z, 2005)	2.02
"Quercetin-4'-glucoside is a major flavonol in onions, and this study investigated the absorption and fate of radiolabeled quercetin-4'-glucoside in rats. "	( Disposition and metabolism of [2-14C]quercetin-4'-glucoside in rats. Caldwell, ST; Crozier, A; Duthie, GG; Edwards, CA; Graf, BA; Hartley, RC; Lean, ME; Mullen, W, 2005)	2.04
"Quercetin is an abundant flavonoid in the human diet with numerous biological activities, which may contribute to the prevention of human disease but also may be potentially harmful. "	( Covalent binding of the flavonoid quercetin to human serum albumin. Kaldas, MI; McMillan, JM; van der Woude, H; Walle, T; Walle, UK, 2005)	2.05
"Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. "	( Tissue distribution of quercetin in rats and pigs. Alink, GM; Arts, IC; de Boer, VC; Dihal, AA; Hollman, PC; Keijer, J; Rietjens, IM; van der Woude, H; Wolffram, S, 2005)	2.08
"Quercetin is a novel antitumor and antioxidant, whose molecular mechanism involved in cell cycle arrest in androgen independent prostate cancer cells remains unclear."	( Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression. Aruldhas, MM; Arunakaran, J; Arunkumar, A; Ilangovan, R; Kanagaraj, P; Vijayababu, MR, 2005)	2.49
"Quercetin is a major flavonoid in plant foods and potentially has beneficial effects on disease prevention. "	( Quercetin appears in the lymph of unanesthetized rats as its phase II metabolites after administered into the stomach. Murota, K; Terao, J, 2005)	3.21
"Quercetin is a potent oxygen free radical scavenger and a metal chelator."	( Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Jerkic, M; López-Novoa, JM; Morales, AI; Pérez-Barriocanal, F; Sánchez-González, PD; Santiago, JM; Vicente-Sánchez, C, 2006)	1.46
"Quercetin is a widely distributed plant flavonoid possessing a variety of chemical and biological activities, including chelation, free-radical scavenging, and antioxidant activity. "	( Quercetin reduces chromosome aberrations induced by atrazine in the Allium cepa test. Bolle, P; Carratù, MR; Evandri, MG; Mastrangelo, S; Tomassetti, M, 2006)	3.22
"Quercetin is a herbal flavonoid derived from various foods of plant origin and plays a role in anti-inflammation. "	( The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils. He, T; He, Y; Li, J; Li, X; Liu, J; Yue, Y, 2005)	2.07
"Quercetin is a kind of flavonoid which has been proved to exhibit anti-tumor activity. "	( Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA. Sun, H; Tang, Y; Xiang, J; Xu, G; Xu, L; Zhang, H; Zhang, Y, 2006)	2.03
"Quercetin is a flavonoid and widely used as an antioxidant and recent studies have revealed its pleiotropic anticancer and antiproliferative capabilities."	( Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Arunakaran, J; Arunkumar, A; Kanagaraj, P; Krishnamoorthy, G; Venkataraman, P; Vijayababu, MR, 2006)	2.5
"Quercetin is a potent chemotherapeutic drug. "	( Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Chen, LJ; Diao, P; Du, XB; Fan, LY; Tang, MH; Wang, GQ; Wang, R; Wei, YQ; Wu, HB; Yang, GL; Yang, HS; Yao, WX; Ye, B; Yuan, ZP; Zhang, W; Zhao, QM; Zhao, X, 2006)	2.18
"Quercetin is a potent oxygen free radicals scavenger and a metal chelator."	( Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Arévalo, MA; Egido, J; Fernández-Tagarro, M; López-Novoa, JM; Mayoral, P; Morales, AI; Pérez-Barriocanal, F; Sandoval, JM; Vicente-Sánchez, C, 2006)	1.37
"Quercetin is a potential chemotherapeutic drug with many biological activities. "	( [Nanoliposomal quercetin inhibits formation of malignant ascites of hepatocellular carcinoma]. Chen, LJ; Fan, LY; Tang, MH; Wei, YQ; Yang, GL; Yuan, ZP, 2006)	2.13
"Quercetin is a typical flavonol-type flavonoid and is present in a variety of vegetables, and their antioxidant effect implies their possible role in the prevention of oxidative stress related chronic diseases. "	( Effects of quercetin and quercetin 3-glucuronide on the expression of bone sialoprotein gene. Arai, M; Araki, S; Kawai, Y; Kim, DS; Mezawa, M; Murota, K; Ogata, Y; Takai, H; Terao, J, 2007)	2.17
"Quercetin is a flavonoid ubiquitously found in nature. "	( Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). Jia, P; Li, X; Liu, H; Liu, X; Mu, C; Yan, Z, 2007)	3.23
"Quercetin is a naturally occurring flavonoid that has a lot of beneficial properties to human health. "	( Modification of membranes by quercetin, a naturally occurring flavonoid, via its incorporation in the polar head group. Gawron, A; Gruszecki, WI; Misiak, L; Paduch, R; Pawelec, J; Pawlikowska-Pawlega, B; Piersiak, T; Zarzyka, B, 2007)	2.07
"Quercetin is a substance of low molecular weight found in vascular plants with a wide range of biological activities including antioxidative and anti-inflammatory activities. "	( Quercetin subunit specifically reduces GlyR-mediated current in rat hippocampal neurons. Cheng, XP; Jiang, P; Sun, H; You-Ye, Z; Zhou, JN, 2007)	3.23
"Quercetin is a naturally-occurring flavonol (a member of the flavonoid family of compounds) that has a long history of consumption as part of the normal human diet. "	( A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Borzelleca, JF; Danielewska-Nikiel, B; Flamm, GW; Harwood, M; Lines, TC; Williams, GM, 2007)	2.03
"Quercetin is a major dietary flavonoid found in onions and other vegetables. "	( Antioxidant capacity of albumin-bound quercetin metabolites after onion consumption in humans. Hayashi, H; Hotta, A; Ido, H; Inakuma, T; Kawai, Y; Moon, JH; Murota, K; Sekido, K; Terao, J, 2007)	2.05
"Quercetin is a well-investigated antioxidant and known to be able to protect against cellular oxidative DNA damage."	( Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro. Briedé, JJ; Kleinjans, JC; Moonen, EJ; Wilms, LC, 2008)	1.3
"Quercetin was shown to be a strong radical scavenger possibly explaining the observed down-regulation of mitochondrial manganese superoxide dismutase by a reduced need for this antioxidant enzyme for maintenance of cellular redox homeostasis."	( Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Chovolou, Y; Kampkötter, A; Proksch, P; Ruhl, S; Timpel, C; Wätjen, W; Zurawski, RF, 2008)	1.3
"Quercetin is an important member of dietary flavonoid family and widely present in red wine and Mediterranean diet. "	( Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment. Dernek, S; Erkasap, N; Ikizler, M; Kaygisiz, Z; Kural, T, 2007)	2.11
"Quercetin is a natural substance found abundantly in grapes, red wine and other food products. "	( Quercetin inhibits choroidal and retinal angiogenesis in vitro. Cao, XG; Chen, Y; Li, XX; Xing, NZ, 2008)	3.23
"Quercetin is a bioflavonoid found in red wine, grapefruit, onions, apples, black tea, and, in lesser amounts, in leafy green vegetables and beans."	( Role of quercetin (a natural herbal compound) in allergy and inflammation. Caraffa, A; Castellani, ML; Cerulli, G; Conti, F; De Lutiis, MA; Madhappan, B; Perrella, A; Salini, V; Shaik, YB; Tete, S; Vecchiet, J, )	1.29
"Quercetin is a flavonoid compound that has been demonstrated to be a potent antioxidant in vitro. "	( Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Dibarnardi, A; Dumke, CL; Henson, DA; Hosick, PA; Hudson, MH; McAnulty, LS; McAnulty, SR; Milne, GL; Morrow, JD; Nieman, DC; Quindry, JC; Still, L; Triplett, NT; Utter, AC, 2008)	2.22
"Quercetin is a flavonoid reported to have health-promoting properties. "	( Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation. Aarts, JM; Lee-Hilz, YY; Rietjens, IM; Stolaki, M; van Berkel, WJ, 2008)	2.04
"Quercetin is a flavonol, also a phytoestrogen, available commonly in onions and apples. "	( Effect of quercetin on bone formation. Rabie, AB; Wong, RW, 2008)	2.19
"Quercetin is a flavonoid and a well-known AhR antagonist, while onion contains many flavonoids, including quercetin."	( Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles. Aizawa, K; Inakuma, T; Izawa, H; Kohara, M; Sagai, M; Suganuma, H; Taya, K; Watanabe, G, 2008)	1.38
"Quercetin is an anti-oxidative flavonoid widely distributed in the plant kingdom. "	( Multitargeted cancer prevention by quercetin. Ashida, H; Murakami, A; Terao, J, 2008)	2.07
"Quercetin is a popular flavonoid compound that is biosynthesized by plants; it is suggested to modulate a variety of inflammatory responses of macrophages and T lymphocytes. "	( Regulatory mechanisms of IL-2 and IFNgamma suppression by quercetin in T helper cells. An, SY; Hong, JH; Hwang, ES; Min, HJ; Won, HY; Yu, ES, 2008)	2.03
"Quercetin is a naturally occurring flavonoid, chemically related to cromolyn. "	( Quercetin inhibition of the induction and function of cytotoxic T lymphocytes. Middleton, E; Schwartz, A; Sutton, SL, 1982)	3.15
"Quercetin is a dietary antioxidant that prevents oxidation of low-density lipoproteins in vitro. "	( Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. de Vries, JH; Hollman, PC; Katan, MB; Mengelers, MJ; van Leeuwen, SD, 1995)	2.05
"Quercetin is a dietary antioxidant that prevents oxidation of low-density lipoproteins in vitro by scavenging to free oxygen radicals. "	( Absorption and disposition kinetics of the dietary antioxidant quercetin in man. de Vries, JH; Hollman, PC; Katan, MB; Mengelers, MJ; van Trijp, JM; vd Gaag, M, 1996)	1.98
"Quercetin is a powerful antioxidant which is widely distributed in edible plants, mainly as glycosides such as rutin. "	( Bioavailability of rutin and quercetin in rats. Demigné, C; Manach, C; Morand, C; Régérat, F; Rémésy, C; Texier, O, 1997)	2.03
"Quercetin is a strong antioxidant and a major dietary flavonoid. "	( Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. Buysman, MN; de Vries, JH; Hollman, PC; Katan, MB; Mengelers, MJ; van der Gaag, MS; van Trijp, JM, 1997)	1.99
"Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells. "	( Effects of quercetin and sunphenon on responses of cancer cells to heat shock damage. Asano, G; Kudo, M; Naito, Z; Yokoyama, M, 1999)	2.14
"Quercetin is a potent antioxidant in vitro, and protection against the oxidative damage to LDL implicated in atherogenesis has been suggested as a possible mechanism."	( The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens. Wiseman, H, 1999)	1.02
"Quercetin is a bioflavonoid with antioxidant and anti-inflammatory activity. "	( Effect of an antioxidant (quercetin) on sodium-lauryl-sulfate-induced skin irritation. Armenaka, M; Davoy, E; Katsarou, A; Theoharides, TC; Xenos, K, 2000)	2.05
"Quercetin is a plant polyphenol which is present in the diet as an aglycone and as sugar conjugates. "	( High-performance liquid chromatographic determination of quercetin and isorhamnetin in rat tissues using beta-glucuronidase and acid hydrolysis. Duthie, GG; Morrice, PC; Wood, SG, 2000)	1.99
"Quercetin-3-rutinoside is an important form of quercetin in foods, but its bioavailability in humans is only 20% of that of quercetin-4'-glucoside."	( Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans. Hollman, PC; Katan, MB; Olthof, MR; Vree, TB, 2000)	1.35
"Quercetin is a flavonoid molecule ubiquitous in nature. "	( Antioxidants and cancer, part 3: quercetin. Brignall, MS; Lamson, DW, 2000)	2.03
"Quercetin is a typical flavonoid present mostly as glycosides in plant foods; it has attracted much attention for its potential beneficial effects in disease prevention. "	( Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women. Inakuma, T; Moon, JH; Nakata, R; Oshima, S; Terao, J, 2000)	2.1
"Quercetin is a flavonoid found in red wine and many other dietary sources. "	( The effect of quercetin, a widely distributed flavonoid in food and drink, on cytosolic aldehyde dehydrogenase: a comparison with the effect of diethylstilboestrol. Kitson, KE; Kitson, TM, 2000)	2.11
"Quercetin is a flavonoid with a wide range of biological activities. "	( Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Alfthan, G; Aro, A; Erlund, I; Kenraali, J; Kosonen, T; Mäenpää, J; Parantainen, J; Perttunen, K, 2000)	2.07
"Quercetin is a very common flavonoid widely distributed in many plants. "	( The effect of quercetin on apoptosis and necrosis induction in human colon adenocarcinoma cell line LS180. Gawron, A; Jakubowicz-Gil, J; Pawlikowska-Pawlega, B; Rzymowska, J, 2001)	2.11
"1. Quercetin is a natural flavonoid present in vegetables, fruit and wine, and is known to inhibit sulphotransferase. "	( Differential inhibition of human liver and duodenum sulphotransferase activities by quercetin, a flavonoid present in vegetables, fruit and wine. De Santi, C; Marchetti, F; Mosca, F; Pacifici, GM; Pietrabissa, A; Spisni, R; Vietri, M, 2001)	1.16
"Quercetin is a naturally occurring chemical found in our daily diet in fruits and vegetables. "	( Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Dunnick, JK; Hailey, JR, 1992)	1.99
"Quercetin is an effective inhibitor of human myeloperoxidase (MPO) activity, both with purified enzyme (IC50 = 3.5 microM) and in a system using stimulated human neutrophils. "	( Human myeloperoxidase activity is inhibited in vitro by quercetin. Comparison with three related compounds. de Bruyn-Dister, M; Deby, C; Goutier, R; Pincemail, J; Thirion, A, 1988)	1.96
"Quercetin was shown to be a potent inhibitor of iron-induced lipid peroxidation with a I50 of 0.2 mM."	( Lipid antioxidant properties of quercetin in vitro. Das, M; Ray, PK, 1988)	1.28
"Quercetin is an equally good inhibitor of xanthine oxidase (type O, oxygen-reducing enzyme) and xanthine dehydrogenase (type D, NAD+-reducing enzyme) activity of a preparation of the xanthine-oxidizing enzyme partially purified from rat liver. "	( Inhibitory action of quercetin on xanthine oxidase and xanthine dehydrogenase activity. Bindoli, A; Cavallini, L; Valente, M, 1985)	2.03

Effects

Quercetin has a variety of biological activities and pharmacological effects. Its clinical application is limited due to its low water solubility, low bioavailability and poor chemical stability. QuercetIn has a potential to modulate P-gp in rodents, but its effects on P-GP modulation in chicken are still unclear.

Isoquercetin (Iso) has been found to have neuroprotective effects against cerebral ischemic stroke. QuercetIn (Que) has anti-tumor activity in addition to its protective effects on various cells.

Excerpt	Reference	Relevance
"Quercetin has a hydrophilic surface region that preferentially establishes donor hydrogen bonds with water molecules with relative frequencies from 0.12 to 0.46 at infinite dilution."	( Structural, dynamic, and hydration properties of quercetin and its aggregates in solution. Campo, MG; Corral, GM, 2022)	1.7
"Quercetin has a wide range of potential health benefits, working as a direct or indirect agent or an adjuvant following different principles. "	( Quercetin as a cancer chemopreventive or chemotherapeutic agent: Where we stand. Boretti, A, 2023)	3.8
"Quercetin has an ideal therapeutic effect on islet function improvement in type 2 diabetes mellitus (T2DM). "	( Controlled SPION-Exosomes Loaded with Quercetin Preserves Pancreatic Beta Cell Survival and Function in Type 2 Diabetes Mellitus. Chen, Y; Lv, X; Qin, D; Rao, L; Xia, H; Xiao, S; Yang, J; Zhu, C; Zhuang, M, 2023)	2.62
"Quercetin has a theoretical, but significant, capability to interfere with SARS-CoV-2 replication, with the results showing this to be the fifth best compound out of 18 candidates."	( A role for quercetin in coronavirus disease 2019 (COVID-19). D'Angelo, A; Derosa, G; Di Pierro, F; Maffioli, P, 2021)	1.73
"Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear."	( Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken. Bhutto, ZA; Guo, T; He, F; Huang, J; Wang, L; Yang, J; Zloh, M, 2018)	1.66
"Quercetin has a variety of biological activities and pharmacological effects, but its clinical application is limited due to its low water solubility, low bioavailability and poor chemical stability. "	( [Research and application of quercetin-loaded nano drug delivery system]. Du, Q; Li, SJ; Liao, YF, 2018)	2.21
"Quercetin has a dose-dependent effect on the fluidity and local order of the lipid membranes, whilst epigallocatechin-3-gallate action is not dose-dependent, the differences being attributable to the hydrophobic/hydrophilic character of the substances."	( Quercetin and epigallocatechin-3-gallate effect on the anisotropy of model membranes with cholesterol. Ganea, C; Iftime, A; Ilie, M; Ionescu, D; Margină, D, 2013)	2.55
"Quercetin has a wide range of biological properties. "	( Isolation and identification of quercetin degrading bacteria from human fecal microbes. Li, S; Peng, X; Wang, Y; Wei, H; Zhang, N; Zhang, Z, 2014)	2.13
"Quercetin has a small beneficial effect for exercise of longer duration (>100 min), but it is unclear whether this benefits athletes."	( Impact of Dietary Antioxidants on Sport Performance: A Review. Braakhuis, AJ; Hopkins, WG, 2015)	1.14
"Quercetin has a substantial anticancer effect on various human cancer cells."	( Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Dong, X; Gu, H; Guo, S; Hisamitsu, T; Liu, Y; Qian, Y; Wang, H; Wang, M; Yang, L, 2016)	2.6
"Quercetin has a strengthening effect on the differentiation of rat bone marrow mesenchymal stem cells into β-cells and increases insulin secretion from the differentiated β-cells in vitro."	( Quercetin potentiates transdifferentiation of bone marrow mesenchymal stem cells into the beta cells in vitro. Khoshdel, Z; Miladpour, B; Mostafavipour, Z; Noorafshan, A; Owji, AA; Rasti, M; Zal, F, 2017)	3.34
"Quercetin has a wide range of biological functions and health-promoting effects."	( Quercetin inhibits human sperm functions by reducing sperm [Ca2+]i and tyrosine phosphorylation. Liang, X; Wang, Y; Xia, Z; Xue, S; Yan, J; Zhang, X, 2016)	2.6
"1) Quercetin has a higher reduction potential compared with curcumin at three different pH settings and is comparable to Trolox at pH 7-9.5; 2) its TAC is 3.5 fold higher than curcumin; 3) it reduced LPS-induced ROS to near normal levels; 4) it reduced LPS-induced NO production. "	( Antioxidant properties of quercetin. Cao, Y; Howell, R; Ju, S; Keng, PC; Liu, C; Okunieff, P; Olek, DJ; Schwartz, L; Swarts, M; Swarts, SG; Tian, Y; Yang, S; Yin, L; Zhang, K; Zhang, L; Zhang, M; Zhang, SB, 2011)	1.29
"Quercetin has an inhibitory effect on Aa and Pg."	( Inhibitory effect of quercetin on periodontal pathogens. Geoghegan, F; Rabie, AB; Tsui, VW; Wong, RW, 2008)	2.11
"Quercetin has an antioxidant and anti-inflammatory activity and prevents cancer."	( Role of quercetin (a natural herbal compound) in allergy and inflammation. Caraffa, A; Castellani, ML; Cerulli, G; Conti, F; De Lutiis, MA; Madhappan, B; Perrella, A; Salini, V; Shaik, YB; Tete, S; Vecchiet, J, )	1.29
"Quercetin has an inhibitory effect on urinary crystal deposit formation."	( Reduction of oxidative stress in cultured renal tubular cells and preventive effects on renal stone formation by the bioflavonoid quercetin. Choi, EY; Jeong, BC; Kim, BS; Kim, HH; Kim, JI; Park, HK; Park, MY; Sung, MK, 2008)	1.99
"Quercetin, which has a better than Ipriflavone water-solubility seems as promising as Ipriflavone in the control of the otosclerotic bone-remodelling disturbance."	( Flavonoids alter bone-remodelling in auditory ossicle organ cultures. Ribári, O; Sziklai, I, 1995)	1.01
"Quercetin, however, has a strong affinity for protein and provides no direct protective effect during LDL oxidation."	( Absorption and antioxidant effects of quercetin from onions, in man. McAnlis, GT; McEneny, J; Pearce, J; Young, IS, 1999)	1.3
"Quercetin has been described as a pro-oxidant that induces the production of reactive oxygen species, which can cause cell death."	( Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes. Almeida-Amaral, EE; Canto-Cavalheiro, MM; Fonseca-Silva, F; Inacio, JD, 2013)	1.38
"Quercetin also has anti-cancer activity, and can be used as an adjuvant to decrease resistance to cancer chemotherapy."	( Quercetin and its role in modulating endoplasmic reticulum stress: A review. Eisvand, F; Seidel, V; Shakeri, A; Tabeshpour, J; Tajbakhsh, A; Zirak, MR, 2022)	2.89
"Quercetin has been extensively studied for its anti-diabetic, anti-hypertensive, anti-Alzheimer's disease, anti-arthritic, anti-influenza virus, anti-microbial infection, anti-aging, autophagy-regulating, and cardiovascular protective effects."	( [Research progress on therapeutic potential of quercetin]. Feng, YL; Li, H; Liu, J; Ruan, Z; Zhai, GY, 2021)	1.6
"Quercetin has been preliminarily proven to serve as a potential agent for the treatment of osteoarthritis (OA). "	( Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis. Ji, Y; Wang, Q; Wei, B; Xu, Y; Ying, L, 2022)	2.55
"Quercetin has demonstrated antioxidant, anti-inflammatory, hypoglycemic, and hypolipidemic activities, suggesting therapeutic potential against type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). "	( Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus. Han, T; Huang, H; Li, L; Sun, K; Zu, G; Zu, X, 2021)	2.43
"Quercetin (Que) has been proved to have various biological activities, including anti-oxidation, anti-inflammation and anti-virus, showing great potential in liver protection. "	( Quercetin loaded liposomes modified with galactosylated chitosan prevent LPS/D-GalN induced acute liver injury. Fan, Y; Liu, H; Nie, H; Wang, L; Wei, X; Xing, Z; Yang, D; Zhao, C, 2021)	3.51
"Quercetin (Que) has been proven to possess strong antioxidant activity, and therefore we investigated whether it had potential protective effect against AC-induced cardiotoxicity."	( Quercetin attenuates the cardiotoxicity of doxorubicin-cyclophosphamide regimen and potentiates its chemotherapeutic effect against triple-negative breast cancer. Li, K; Li, S; Zhang, J; Zhang, P; Zhao, L, 2022)	2.89
"Quercetin (Que) has many pharmacological activities, such as anticancer, antioxidant, cardiovascular protection, antihypertensive and lipid-lowering activities. "	( Encapsulating quercetin in cyclodextrin metal-organic frameworks improved its solubility and bioavailability. Hua, C; Jiang, H; Jiang, Y; Ma, Y; Wang, R; Wang, Z; Wu, Y; Xu, Q; Zhou, F, 2022)	2.52
"Quercetin has been reported to have antitumor activity of a wide range of cancers, including breast, lung, colon, prostate. "	( Quercetin Inhibits Glioblastoma Growth and Prolongs Survival Rate through Inhibiting Glycolytic Metabolism. Ji, S; Liu, Z; Wang, L; Zhao, J, 2022)	3.61
"Quercetin, has many biological effects in the prevention and treatment of cancer."	( Quercetin's effects on colon cancer cells apoptosis and proliferation in a rat model of disease. Abdolazimi, H; Fallah, A; Nazari Robati, F; Talaei, B; Tezerji, S, 2022)	2.89
"Quercetin has been shown to inhibit the growth of different Gram-positive and Gram-negative bacteria as well as fungi and viruses."	( Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle. Bhattacharya, D; Nguyen, TLA, 2022)	1.74
"Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties."	( Health Benefits of Quercetin in Age-Related Diseases. Maurya, PK, 2022)	1.77
"Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity."	( Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications. Asemi, Z; Malakoti, F; Moein, S; Qujeq, D; Vaghari-Tabari, M; Yan, L; Yousefi, B, 2023)	3.07
"Quercetin has a hydrophilic surface region that preferentially establishes donor hydrogen bonds with water molecules with relative frequencies from 0.12 to 0.46 at infinite dilution."	( Structural, dynamic, and hydration properties of quercetin and its aggregates in solution. Campo, MG; Corral, GM, 2022)	1.7
"Quercetin has been proved to exert anti-inflammation in ALI."	( Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways. Li, X; Sang, A; Song, X; Wang, Q; Wang, S; Wang, X; Wang, Y, 2022)	2.89
"Quercetin has been a focal point in recent years due to its versatile health-promoting benefits and high pharmacological values."	( The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy. Chang, W; Chen, X; Wang, M; Yu, F; Zhang, L; Zhang, Y, 2022)	1.72
"Quercetin has anti-inflammation, antioxidant, antifibrosis activity in the CKD cells model. "	( Quercetin prevents chronic kidney disease on mesangial cells model by regulating inflammation, oxidative stress, and TGF-β1/SMADs pathway. Afifah, E; Arumwardana, S; Kusuma, HSW; Maulana, MA; Onggowidjaja, P; Prahastuti, S; Rizal, R; Tjokropranoto, R; Widowati, W, 2022)	3.61
"Quercetin (Que) has been used to treat cardiovascular diseases such as arrhythmias."	( Mechanisms of Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation. Chen, Y; Gao, Q; Geng, J; Kang, P; Li, X; Tan, X; Tang, B; Wang, H; Wang, Q; Xian, W, 2022)	1.8
"Quercetin has been reported to alleviate radiation-induced salivary gland damage, yet the effect of quercetin on SS-caused salivary gland damage remains unclear."	( Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB-R signaling. Chang, L; Chen, P; Guo, Y; Kong, A; Sun, Y; Wang, X; Zhang, J, 2022)	2.89
"Quercetin has multiple protective effects against cardiometabolic diseases, but the biological mechanisms underlying the benefits in diabetic cardiomyopathy (DCM) are unclear. "	( Quercetin ameliorated cardiac injury Chen, L; Gao, C; Jiang, C; Li, D; Liu, Y; Mei, G; Tang, Y; Yang, Y; Yao, P; Zhao, Y, 2022)	3.61
"Quercetin has shown prominent inhibitory effects on the JAK-STAT pathway in terms of anti-inflammatory and antitumor activity, as well as control of neurodegenerative diseases."	( Quercetin as a JAK-STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases. Dana, VG; Farahighasreaboonasr, F; Forghaniesfidvajani, R; Nabi-Afjadi, M; Pakizeh, F; Seif, F; Tavakol, C; Zalpoor, H, 2022)	2.89
"Quercetin has been shown to have a wide range of beneficial effects, such as anti-inflammation, anti-oxidation and immunomodulation. "	( Quercetin protects rat BMSCs from oxidative stress via ferroptosis. Lan, D; Li, X; Liu, H; Qi, S; Wang, D; Wang, Y; Yao, C, 2022)	3.61
"Yet, quercetin has the potential to reduce the side effects of crude oil vapor on the male reproductive system."	( Potential protective effect of quercetin on the male reproductive system against exposure of Wistar rats to crude oil vapor: Genetic, biochemical, and histopathological evidence. Basir, Z; Daaj, SAZ; Khazaeel, K; Sadeghi, A; Tabandeh, MR, 2022)	1.46
"Quercetin has been demonstrated as anti-cancer role in cancer development."	( Quercetin Mediated TET1 Expression Through MicroRNA-17 Induced Cell Apoptosis in Melanoma Cells. Ding, D; Feng, Y; Gao, Y; Hou, R; Li, C; Li, J; Lin, C; Wang, D; Xia, Q; Xue, T, 2023)	3.07
"Quercetin has gained recognition over the years because of its anti-cancer effect with minimal toxicity."	( Quercetin induces autophagy-associated death in HL-60 cells through CaMKKβ/AMPK/mTOR signal pathway. Huang, K; Li, Y; Liu, H; Liu, X; Nie, D; Wang, J; Xiao, J; Xie, S; Yang, W; Yin, S; Zhang, B; Zhang, G, 2022)	2.89
"Quercetin (QCT) has antioxidant, anti-inflammatory, anti-tumor and other important pharmacological activities, but the poor water solubility limits its application. "	( Dual-grafted dextran based nanomicelles: Higher antioxidant, anti-inflammatory and cellular uptake efficiency for quercetin. Chen, S; Chen, Y; He, Z; Huang, G; Li, P; Liu, Y; Song, S; Wang, C; Wang, H; Yang, Z; Zhou, C, 2023)	2.56
"Quercetin has been shown to be preventative against many forms of neuronal cell death resulting from glutamate excitotoxicity, such as oncosis, intrinsic apoptosis, mitochondrial permeability transition, ferroptosis, phagoptosis, lysosomal cell death, parthanatos, and death by reactive oxygen species (ROS)/reactive nitrogen species (RNS) generation."	( Quercetin's Effects on Glutamate Cytotoxicity. Lenard, NR; Riche, K, 2022)	2.89
"Quercetin has a wide range of potential health benefits, working as a direct or indirect agent or an adjuvant following different principles. "	( Quercetin as a cancer chemopreventive or chemotherapeutic agent: Where we stand. Boretti, A, 2023)	3.8
"Quercetin has long been used as a natural medicine but its photoactivity has been neglected."	( Phytochemicals-based edible coating for photodynamic preservation of fresh-cut apples. Du, T; Li, X; Su, Z; Sun, H; Wang, J; Wang, S; Zhang, W, 2023)	1.63
"Quercetin has been proven to be effective for cancer treatment, including nasopharyngeal carcinoma (NPC). "	( Quercetin acts as a novel anti-cancer drug to suppress cancer aggressiveness and cisplatin-resistance in nasopharyngeal carcinoma (NPC) through regulating the yes-associated protein/Hippo signaling pathway. Li, T; Li, Y, 2023)	3.8
"Quercetin has the potential to ameliorate diabetes induced pulmonary dysfunction by targeting NLRP3."	( Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway. El-Shaer, NO; Hegazy, AM; Muhammad, MH, 2023)	1.95
"Quercetin has been reported to be a modulator of proliferation and survival in various types of cancers due to its cytotoxic effects."	( Quercetin Induces Cell Cycle Arrest and Apoptosis in YD10B and YD38 Oral Squamous Cell Carcinoma Cells. Kim, D; Son, HK, 2023)	3.07
"Quercetin has been shown to reduce the loss of striatal neurons, which may enhance motor capabilities and protect against agents that cause the production of reactive oxygen species (ROS)."	( Inhibition of drug induced Parkinsonism by chronic supplementation of quercetin in haloperidol-treated wistars. Arshad, M; Farhan, M; Rafi, H; Rafiq, H; Rehman, S; Shakeel, S, 2022)	1.68
"Quercetin has been studied extensively for its anti-Alzheimer's disease (AD) and anti-aging effects. "	( A Diet Containing Rutin Ameliorates Brain Intracellular Redox Homeostasis in a Mouse Model of Alzheimer's Disease. Benedí, J; Bermejo-Bescós, P; Jiménez-Aliaga, KL; Martín-Aragón, S, 2023)	2.35
"Quercetin has anti-allergic biological activity in AR."	( Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis. Chen, Z; Hong, S; Kang, H; Ke, X; Wang, X, 2023)	3.07
"Quercetin (QC) has been shown to affect CSC viability, but its low bioavailability limits its clinical use."	( Effective inhibition of breast cancer stem cell properties by quercetin-loaded solid lipid nanoparticles via reduction of Smad2/Smad3 phosphorylation and β-catenin signaling pathway in triple-negative breast cancer. Hatami, M; Kheirollah, A; Khorsandi, L; Kouchak, M; Rashidi, M, 2023)	1.87
"Quercetin has potentially beneficial therapeutic effects for several diseases, including cigarette smoking-induced chronic obstructive pulmonary disease (CS-COPD)."	( The therapeutic potential of quercetin for cigarette smoking-induced chronic obstructive pulmonary disease: a narrative review. Chen, J; Ding, K; Jia, H; Jiang, W; Lei, M; Wang, Y; Xiong, C; Zhan, W, )	1.14
"Quercetin (QR) has significant anti-respiratory syncytial virus (RSV) effects. "	( Integrating metabolomics and network pharmacology to assess the effects of quercetin on lung inflammatory injury induced by human respiratory syncytial virus. Hu, CC; Jiang, MC; Li, XM; Sun, YL; Tao, JL; Yuan, B; Zhao, PP; Zhu, CB, 2023)	2.58
"Quercetin has shown beneficial effects on cartilage during OA across animal species. "	( Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies. Bahney, C; Huard, J; Nelson, AL; Nishimura, H; Philippon, MJ; Ravuri, SK; Rutledge, JC; Yamaura, K, 2023)	2.62
"Quercetin has also been demonstrated to exert a striking antiinflammatory effect mainly by inhibiting the production of cytokines, reducing the expression of cyclooxygenase and lipoxygenase, and preserving the integrity of mast cells."	( Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders. Dong, G; Lu, Y; Qian, C; Song, M; Tang, Y; Wang, A; Yang, C; Zhang, T; Zhao, Y; Zheng, W; Zhong, C; Zhou, Y, 2023)	1.9
"Quercetin, a flavonoid, has demonstrated various therapeutic properties, such as antioxidant, anti-diabetic, anti-hypertensive, and anti-carcinogenic activities."	( Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives. Alizadeh, SR; Ebrahimzadeh, MA; Savadkouhi, N, )	1.07
"Quercetin has been studied extensively when used with various nanodelivery systems for enhancing quercetin bioavailability."	( Nano Drug Delivery Strategies for an Oral Bioenhanced Quercetin Formulation. Attar, ES; Chaudhari, VH; Deokar, CG; Devarajan, PV; Dyawanapelly, S, 2023)	1.88
"Quercetin (Que) has been proven to enhance the chemosensitivity of multiple cancers, including colon cancer (CC). "	( Quercetin reverses 5-fluorouracil resistance in colon cancer cells by modulating the NRF2/HO-1 pathway. Chen, Y; Liu, B; Tang, Z; Wang, H; Wang, L; Wang, R; Zhang, S; Zheng, X, 2023)	3.8
"Both quercetin and leucine have been shown to exert moderately beneficial effects in preventing muscle atrophy induced by cancers or chemotherapy. "	( The combination of quercetin and leucine synergistically improves grip strength by attenuating muscle atrophy by multiple mechanisms in mice exposed to cisplatin. Hsu, TH; Huang, CS; Liao, JW; Tai, YA; Wu, TJ; Yeh, SL, 2023)	1.75
"Quercetin has an ideal therapeutic effect on islet function improvement in type 2 diabetes mellitus (T2DM). "	( Controlled SPION-Exosomes Loaded with Quercetin Preserves Pancreatic Beta Cell Survival and Function in Type 2 Diabetes Mellitus. Chen, Y; Lv, X; Qin, D; Rao, L; Xia, H; Xiao, S; Yang, J; Zhu, C; Zhuang, M, 2023)	2.62
"Quercetin has been widely found to exhibit anticancer activity with low toxicity and prevalence in foods. "	( Prediction of new targets and mechanisms for quercetin in the treatment of pancreatic cancer, colon cancer, and rectal cancer. Jiang, C; Jin, H; Liu, Y; Lu, Y; Pang, B; Shao, D; Shi, J; Xu, X; Yang, R, 2019)	2.22
"Quercetin has valuable biological and therapeutic effects such as anti-tumor, antioxidant, anti-inflammatory, anti-diabetic, hepatoprotective, and cardioprotective."	( Autophagy as a molecular target of quercetin underlying its protective effects in human diseases. Ahmadi, Z; Ashrafizadeh, M; Farkhondeh, T; Samarghandian, S, 2022)	1.72
"Quercetin has multiple intracellular targets in a cancer cell."	( Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health. Bhagat, M; Rather, RA, 2020)	2.72
"Quercetin has been shown to inhibit proliferation and invasion of various glioma cells and is regarded as a potential anticancer agent against glioma."	( Quercetin depletes intracellular Ca Chan, P; Chen, CY; Hour, MJ; Leung, YM; Shiao, LR; So, EC; Wong, KL, 2020)	2.72
"Quercetin has pharmacological functions in PD by controlling different molecular pathways."	( The Therapeutic Potential of Quercetin in Parkinson's Disease: Insights into its Molecular and Cellular Regulation. Asemi, Z; Behnam, M; Fallah, M; Hadinezhad, T; Shahmirzadi, AR; Taghizadeh, M; Tamtaji, OR, 2020)	1.57
"Bulk quercetin has low bioavailability and thus, from obtained data we suggest that LA-Q-ORMOSIL nanoparticles provide high therapeutic value in protecting experimental animals against CP-induced liver injury."	( Lactobionic Acid Conjugated Quercetin Loaded Organically Modified Silica Nanoparticles Mitigates Cyclophosphamide Induced Hepatocytotoxicity. Flora, SJ; Naqvi, S; Sharma, H, 2019)	1.26
"Quercetin has excellent antioxidant properties and preventative effects."	( Quercetin Reduces Ischemic Brain Injury by Preventing Ischemia-induced Decreases in the Neuronal Calcium Sensor Protein Hippocalcin. Jeon, SJ; Kang, JB; Koh, PO; Park, DJ, 2020)	2.72
"Quercetin has been certified with the effect on improving diabetes mellitus (DM) and cognitive impairment."	( Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice. Chen, QB; Chen, YB; Hu, T; Liu, XQ; Lu, XY; Shi, JJ; Wang, Q; Zhang, SJ, 2020)	2.72
"Quercetin (Qc) has shown great potential as a chemopreventive agent and has been widely studied for the treatment of diseases such as bladder cancer."	( New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer. Alban, L; Diz, FM; Ligabue, R; Miranda, GM; Monteiro, WF; Morrone, FB; Scheid, CM; Zotti, ER, 2020)	1.84
"Quercetin has been reported to be effective in improving cognitive dysfunction in DE."	( Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mice. Chen, YB; Fang, J; Hu, T; Shi, JJ; Wang, Q; Zhang, SJ, 2020)	2.72
"Quercetin Dihydrate has been studied in cardiovascular disease, but its effect on myocardial fibrosis is not clear."	( Quercetin Dihydrate inhibition of cardiac fibrosis induced by angiotensin II in vivo and in vitro. An, X; Tan, A; Wang, L; Xia, Y; Xie, Y, 2020)	2.72
"Quercetin(Que) has multiple pharmacological properties, and is regarded as a potential protective agent against a variety of organ injuries."	( Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway. Gao, H; Qu, X; Song, Y; Sun, J; Tao, L; Zhai, J; Zhang, J; Zhang, Y, 2020)	2.72
"Quercetin has pleiotropic action like anti-oxidant, regulation cell cycle &vascular integrity, and preventive effect of neuroinflammation."	( Therapeutic investigation of quercetin nanomedicine in a zebrafish model of diabetic retinopathy. Du, S; Wang, S; Wang, W; Zhang, F, 2020)	1.57
"Quercetin has no demonstrable toxicity in humans, further supporting the possibility of using quercetin therapeutically."	( Quercetin Inhibits Proliferation and Induces Apoptosis of B16 Melanoma Cells Berry, IM; Kumari, D; Moore, TC; Soll, F; Ternent, C, )	2.3
"Quercetin has various biological activities, but its poor water solubility and stability limit its applications. "	( Characterization and bacteriostatic effects of β-cyclodextrin/quercetin inclusion compound nanofilms prepared by electrospinning. Li, F; Liu, L; Shen, W; Wang, M; Wang, Z; Zou, W, 2021)	2.3
"Quercetin has a theoretical, but significant, capability to interfere with SARS-CoV-2 replication, with the results showing this to be the fifth best compound out of 18 candidates."	( A role for quercetin in coronavirus disease 2019 (COVID-19). D'Angelo, A; Derosa, G; Di Pierro, F; Maffioli, P, 2021)	1.73
"Quercetin has been in the spotlight over the years because of its high pharmacological values and substantial evidence has demonstrated its anti-proliferative effect against various types of cancers."	( Quercetin and MicroRNA Interplay in Apoptosis Regulation in Ovarian Cancer. Cho, WC; Javed, Z; Khan, K; Luparello, C; Sadia, H; Sharifi-Rad, J, 2021)	2.79
"Quercetin has been proved to have high medicinal value, and as a type of flavonol, has been found in many plants. "	( Borate-modified carbon dots as a probe for quercetin in plants. Gao, M; He, M; Wang, X; Wang, Z; Xing, R, 2021)	2.33
"Quercetin has potential against the Multidrug Resistance (MDR) phenotype, but with low bioavailability. "	( Anti-MDR Effects of Quercetin and its Nanoemulsion in Multidrug-Resistant Human Leukemia Cells. Araújo, GS; Cañedo, AD; Carrett-Dias, M; da Silva Alves, B; da Silva Júnior, FMR; de Oliveira, BS; de Souza Votto, AP; Dora, CL; Fernandes E Silva, E; Filgueira, DMVB; Machado, AP; Marques, MB; Santos, PA, 2021)	2.39
"Quercetin has potential value in treating cardiovascular diseases, but it is not suitable for clinical application due to its own water solubility. "	( Effect of Quercetin-Loaded Mesoporous Silica Nanoparticles on Myocardial Ischemia-Reperfusion Injury in Rats and Its Mechanism. Hu, YM; Liu, CJ; Yao, L; Zhao, BT, 2021)	2.47
"Quercetin has been also reported to modulate the activity of some members of the multidrug-resistance transporters family, such as P-gp, ABCC1, ABCC2, and ABCG2, and the activity of ecto-5'-nucleotidase (NT5E/CD73), a key regulator in some tumor processes such as invasion, migration, and metastasis."	( Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration. Abruzzese, V; Bisaccia, F; Carmosino, M; Koshal, P; Martinelli, F; Matera, I; Milella, L; Ostuni, A, 2021)	1.75
"Quercetin has been shown to have anti-obesity effects, but it is unknown whether these effects can be transmitted from mothers to their progeny. "	( Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet. Matsuyama, H; Sakakibara, H; Tajiri, H; Takashima, M; Tanaka, W, 2021)	2.48
"Quercetin (QUR) has been used as model lipophilic drug in this study."	( Exploring role of polysaccharides present in Ganoderma lucidium extract powder and probiotics as solid carriers in development of liquisolid formulation loaded with quercetin: A novel study. Chellappan, DK; Dua, K; Gulati, M; Gupta, G; Jha, NK; Kapoor, B; Kapoor, DN; Karri, VVSR; Khursheed, R; Mondal, S; Pandey, NK; Pattanayak, P; Sharni, A; Singh, SK; Wadhwa, S, 2021)	1.54
"Quercetin (QUE) has chemo-preventive effect against a variety of cancers."	( Quercetin Inhibits the Epithelial to Mesenchymal Transition through Suppressing Akt Mediated Nuclear Translocation of β-Catenin in Lung Cancer Cell Line. Elumalai, P; Ezhilarasan, D; Raghunandhakumar, S, 2022)	2.89
"Quercetin has been investigated as an agent to treat rheumatoid arthritis. "	( Low dose of quercetin-loaded pectin/casein microparticles reduces the oxidative stress in arthritic rats. Bracht, A; Bracht, L; Carvalho, AS; Comar, JF; Gonçalves, OH; Moreira, LS; Oliveira, BPM; Sá-Nakanishi, AB; Silva, BT; Silva, PS; Souza, KS; Verri, WA; Zanoni, JN, 2021)	2.44
"Quercetin has better cytoprotective effect than SnPP."	( Quercetin and tin protoporphyrin attenuate hepatic ischemia reperfusion injury: role of HO-1. Abdel-Mottaleb, Y; Atef, Y; El-Fayoumi, HM; Mahmoud, MF, 2017)	2.62
"Quercetin (Qu) intake has been associated with reduced incidence and slow development of GC, probably due to its anti-proliferative and apoptotic effects, but it is unclear whether Qu can inhibit the metastatic activity."	( Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-κb, PKC-δ, ERK1/2, and AMPKα. Chen, C; Li, H, 2018)	2.64
"Quercetin has been found to be very efficacious against many different types of cancer cells. "	( Quercetin induces apoptosis and necroptosis in MCF-7 breast cancer cells. Abbaspour, MR; Khodadadi, A; Khorsandi, L; Mansouri, E; Niazvand, F; Orazizadeh, M, )	3.02
"Quercetin (Que) has been confirmed to have a neuro-protective effect during nerve damage processes."	( Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats. Jin, D; Li, G; Li, W; Lin, C; Luo, J; Wang, M; Wang, Y; Zhou, X, 2018)	2.64
"Quercetin has been shown to induce expression of hypoxia-inducible factor, a protein that is known to regulate transcription of the erythropoietin (EPO) gene, and EPO is known to have a cytoprotective effect."	( Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells. Matsumoto, R; Nakagawa, H; Nishimura, K; Yonezawa, Y, 2017)	1.58
"Quercetin (QU) has been shown obvious anti-arthritic property in pre-clinical studies or clinical studies. "	( Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. Wu, X; Xu, M; Yang, Y; Zhang, X; Zhao, C; Zhao, F, 2018)	3.37
"Quercetin has been demonstrated to quench production of intracellular free iron-induced -OH, but the effect of quercetin in ethanol-induced cardiac damage remains unclear."	( Quercetin Attenuates Ethanol-Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II-L-Type Calcium Channel. Chen, M; Dong, Z; Gao, C; Guo, X; Liu, J; Liu, P; Tang, Y; Yao, P; Zeng, H; Zhang, J; Zhou, F; Zhu, X, 2018)	2.64
"Quercetin, a flavonoid, has been reported to ameliorate cardiovascular diseases, such as cardiac hypertrophy. "	( Quercetin Prevents In Vivo and In Vitro Myocardial Hypertrophy Through the Proteasome-GSK-3 Pathway. Chen, K; Li, S; Liu, Y; Luo, J; Rekep, M; Tian, J; Wei, W; Wu, Q; Xiao, Q; Xue, Q; Yi, Q; Zhang, G, 2018)	3.37
"Isoquercetin (Iso) has been found to have neuroprotective effects against cerebral ischemic stroke. "	( Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. Dai, Y; Yan, M; Zhang, H; Zhang, J, 2018)	1.72
"Quercetin (Que) has anti-tumor activity in addition to its protective effects on various cells."	( Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. Li, K; Li, S; Wang, B; Wang, X; Yuan, S; Zhao, Q, 2018)	2.64
"Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear."	( Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken. Bhutto, ZA; Guo, T; He, F; Huang, J; Wang, L; Yang, J; Zloh, M, 2018)	1.66
"Quercetin has been reported to improve the symptoms of CP/CPPS patients."	( Quercetin protects against chronic prostatitis in rat model through NF-κB and MAPK signaling pathways. Chen, D; Chen, DX; Cheng, WL; He, QB; Ma, LX; Meng, LQ; Shi, BK; Wang, MS; Xing, NZ; Yang, FY; Zhou, Q, 2018)	2.64
"Quercetin has specific protective effect on CP/CPPS, which is mediated by anti-inflammation, anti-oxidation, and at least partly through NF-κB and MAPK signaling pathways."	( Quercetin protects against chronic prostatitis in rat model through NF-κB and MAPK signaling pathways. Chen, D; Chen, DX; Cheng, WL; He, QB; Ma, LX; Meng, LQ; Shi, BK; Wang, MS; Xing, NZ; Yang, FY; Zhou, Q, 2018)	3.37
"Quercetin conjugates have been detected in plasma and in urine, but their presence in the small intestine has not been assessed."	( Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers. Augustijns, P; Chalet, C; Duchateau, GS; Rubbens, J; Tack, J, 2018)	1.5
"Quercetin has been reported to exert many beneficial effects on the protection against various diseases, such as diabetes, cancer, and inflammation. "	( The effects of biodegradable poly(lactic-co-glycolic acid)-based microspheres loaded with quercetin on stemness, viability and osteogenic differentiation potential of stem cell spheroids. Jeong, JH; Kim, M; Lee, H; Nguyen, TT; Park, JB, 2018)	2.14
"Quercetin (Que) has consistently been reported to be useful cytotoxic compound in vivo and in vitro, but little is known on its metabolites. "	( Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. Kroon, PA; Needs, PW; Shao, H; Wu, Q; Yang, X, 2018)	2.23
"Quercetin has a variety of biological activities and pharmacological effects, but its clinical application is limited due to its low water solubility, low bioavailability and poor chemical stability. "	( [Research and application of quercetin-loaded nano drug delivery system]. Du, Q; Li, SJ; Liao, YF, 2018)	2.21
"Quercetin (QCT) has been known as a potential therapeutic strategy for gastrointestinal diseases because it contributes to the stabilization of mast cells, the prevention of histamine release and modulation of CaCC chloride channel."	( Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. Choi, JY; Choi, YW; Hong, JT; Hwang, DY; Kim, JE; Kim, KM; Lee, MR; Park, JJ; Son, HJ; Song, BR, 2018)	3.37
"Quercetin has been shown to inhibit PhIP formation by trapping phenylacetaldehyde to form two human beneficial adducts 6-C-(E-phenylethenyl)quercetin (6-CEPQ) and 8-C-(E-phenylethenyl)quercetin (8-CEPQ)."	( A comparison of mutagenic PhIP and beneficial 8-C-(E-phenylethenyl)quercetin and 6-C-(E-phenylethenyl)quercetin formation under microwave and conventional heating. Cheng, KW; Fan, D; Li, L; Wang, M; Wang, Q; Yan, B; Zhang, H; Zhang, N; Zhao, J; Zhao, Y, 2018)	1.44
"Quercetin has important biological activities related to the improvement of the wound healing process."	( Quercetin and its Natural Sources in Wound Healing Management. Aiello, F; Badolato, M; Carullo, G; Perri, F; Polerà, N, 2019)	2.68
"Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent."	( Quercetin in Food: Possible Mechanisms of Its Effect on Memory. Babaei, F; Mirzababaei, M; Nassiri-Asl, M, 2018)	2.64
"Quercetin has attracted considerable attention because of its amazingly high pharmacological value."	( Quercetin-mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer. Attar, R; Farooqi, AA; Jabeen, S; Xu, B; Yaylim, I, 2018)	2.64
"Quercetin has multiple intracellular molecular targets with the potential to reverse treatment resistance and affect pleiotropic signaling processes that are altered in cancer cells."	( Potential of the Flavonoid Quercetin to Prevent and Treat Cancer - Current Status of Research. Břetislav, G; Jana, N; Pavel, S; Pavla, U, )	1.15
"Quercetin has been reported to suppress protein glycation or the formation of advanced glycation end-products (AGEs), but the inhibition mechanism related to protein structure and glycation sites and the influence on physicochemical properties remain unclear. "	( Insights into the Mechanism of Quercetin against BSA-Fructose Glycation by Spectroscopy and High-Resolution Mass Spectrometry: Effect on Physicochemical Properties. Chen, J; Lu, Y; Tu, ZC; Wang, H; Wang, HH; Yang, SH; Ye, YH; Yuan, T; Zhang, L, 2019)	2.24
"Quercetin (Q) has rapid metabolism, which may make it worthwhile to focus on the potential activity of its metabolites. "	( Effects of Quercetin Metabolites on Triglyceride Metabolism of 3T3-L1 Preadipocytes and Mature Adipocytes. Eseberri, I; González-Manzano, S; Lasa, A; Miranda, J; Mosqueda-Solís, A; Portillo, MP; Santos-Buelga, C, 2019)	2.35
"Quercetin has strong binding affinity towards CD4, CD8 and CD28, CD45 receptors and protects the thymocytes and splenocytes against DLM-induced apoptotic signaling pathways."	( Deltamethrin-Induced Immunotoxicity and its Protection by Quercetin: An Experimental Study. Gupta, M; Kumar, A; Sharma, N; Sharma, R, 2020)	2.25
"Quercetin (QCT) has important functions such as antioxidant, anti-inflammatory and anticancer. "	( Self-assembled amphiphilic chitosan nanomicelles to enhance the solubility of quercetin for efficient delivery. Chen, Y; He, Z; Li, P; Li, S; Liu, X; Wang, C; Wang, H; Yang, Z; Zhou, C, 2019)	2.18
"Quercetin (QCT) has been shown to have anticancer activities associated with apoptosis and autophagy induction. "	( Quercetin inhibits growth of hepatocellular carcinoma by apoptosis induction in part via autophagy stimulation in mice. Ji, Y; Li, L; Li, WT; Ma, YX; Wu, MH; Zhou, JR; Zhu, HZ, 2019)	3.4
"Quercetin has been shown to display intensive antioxidant activity against ROS-mediated damage in chilled semen, and the effects and molecular mechanisms of Quercetin on sperm function in the infertile patients with leukocytospermia remain largely unknown."	( In vitro antioxidation effect of Quercetin on sperm function from the infertile patients with leukocytospermia. Cai, X; Diao, R; Duan, YG; Gan, H; Song, X; Tian, F; Zhen, W, 2019)	2.24
"Quercetin has potential pharmacological values in various carcinomas including oral squamous cell carcinoma (OSCC). "	( Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/β-catenin axis. Hao, Y; Liu, P; Sun, Y; Zhang, C, 2019)	3.4
"Quercetin has good anti-inflammatory effects and immunomodulatory activities."	( Quercetin reduces TNF-α-induced mesangial cell proliferation and inhibits PTX3 production: Involvement of NF-κB signaling pathway. Fan, H; Huang, Y; Ji, K; Li, X; Liu, Y; Qi, D; Wang, X; Wang, Y; Xie, H; Yu, C, 2019)	2.68
"Quercetin has a dose-dependent effect on the fluidity and local order of the lipid membranes, whilst epigallocatechin-3-gallate action is not dose-dependent, the differences being attributable to the hydrophobic/hydrophilic character of the substances."	( Quercetin and epigallocatechin-3-gallate effect on the anisotropy of model membranes with cholesterol. Ganea, C; Iftime, A; Ilie, M; Ionescu, D; Margină, D, 2013)	2.55
"Quercetin a flavonoid, has been reported to lower the risk of several cancers."	( Anti-cancer activity of quercetin in neuroblastoma: an in vitro approach. Arunakaran, J; Arunkumar, R; Bavithra, S; Brindha Mercy, A; Elumalai, P; Raja Singh, P; Selvakumar, K; Sugantha Priya, E, 2014)	1.43
"And quercetin has effect on intracellular Ca2+ releasing via IP3 of sarcoplasmic reticulum."	( [Influences of quercetin on contraction of small intestine smooth muscle of rabbits in vitro and its mechanism]. Gao, Y; Shao, ZW; Wang, QY; Zhang, J, 2013)	1.22
"Quercetin has been shown to be a potent antioxidant, acts hepatoprotectively, and affects glucose and lipid metabolism in monogastrics. "	( Influence of 4-week intraduodenal supplementation of quercetin on performance, glucose metabolism, and mRNA abundance of genes related to glucose metabolism and antioxidative status in dairy cows. Gohlke, A; Görs, S; Hammon, HM; Ingelmann, CJ; Metges, CC; Nürnberg, G; Starke, A; Weitzel, JM; Wolffram, S, 2013)	2.08
"Quercetin has been shown to modulate obesity-induced inflammation, but the mechanism of its action remains unclear."	( Quercetin suppresses MIP-1α-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling. Choe, SY; Hong, SM; Kang, JH; Kim, CS; Noh, HJ; Park, JY; Park, T; Yoo, H; Yu, R, 2014)	2.57
"Quercetin has been shown to inhibit intestinal P-glycoprotein-mediated drug efflux. "	( Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans - Implications for the evaluation of transporter-mediated flavonoid-drug interactions. Langguth, P; Nguyen, MA; Staubach, P; Wolffram, S, 2014)	2.09
"Quercetin has been demonstrated to play an important role in altering the progression of ischemic brain injuries and neurodegenerative diseases by protecting against oxidative stress. "	( Protective effect of quercetin against oxidative stress and brain edema in an experimental rat model of subarachnoid hemorrhage. Dong, YS; Feng, DY; Gao, GD; Li, C; Qin, HZ; Wang, JL; Wen, H; Yin, ZM, 2014)	2.16
"Quercetin has the potential as functional feed additive in animal production."	( Effects of dietary supplementation of quercetin on performance, egg quality, cecal microflora populations, and antioxidant status in laying hens. Feng, XA; Hu, LL; Jin, F; Li, Y; Liu, HN; Liu, Y; Suo, YL; Teng, N; Zhang, L, 2014)	1.39
"Quercetin has a wide range of biological properties. "	( Isolation and identification of quercetin degrading bacteria from human fecal microbes. Li, S; Peng, X; Wang, Y; Wei, H; Zhang, N; Zhang, Z, 2014)	2.13
"Quercetin has many pharmaceutical applications, many of which arise from its potent antioxidant properties."	( Intracellular ROS protection efficiency and free radical-scavenging activity of quercetin and quercetin-encapsulated liposomes. Barzegar, A; Eidi, A; Rezaei-Sadabady, R; Zarghami, N, 2016)	1.38
"Quercetin (QUR) has been shown to induce anti-, as well as, pro-oxidant effects depending on the dose and on the redox state of the cell. "	( Dual effects of quercetin in doxorubicin-induced nephrotoxicity in rats and its modulation of the cytotoxic activity of doxorubicin on human carcinoma cells. Heeba, GH; Mahmoud, ME, 2016)	2.22
"Quercetin has been demonstrated to exhibit cytoprotective effects through the induction of heme oxygenase (HO)-1."	( Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury. Hasegawa, Y; Hashimoto, K; Hashimoto, N; Kawabe, T; Matsushima, M; Nose, H; Sato, M; Takashima, K, 2014)	1.38
"Quercetin has been confirmed to possess antihistamine, anti-inflammatory, antiviral, immunomodulatory, and antioxidant properties. "	( Quercetin inhibits proliferation and drug resistance in KB/VCR oral cancer cells and enhances its sensitivity to vincristine. Hu, Z; Huang, Y; Sun, S; Wang, H; Wu, B; Yao, F; Yuan, Z, 2015)	3.3
"Quercetin has several biological effects including antioxidative, anti-inflammatory, and anti-allergic effects."	( Effect of topical application of quercetin-3-O-(2″-gallate)-α-l-rhamnopyranoside on atopic dermatitis in NC/Nga mice. Jeong, MS; Joo, SS; Kim, JY; Lee, MW; Park, EJ; Park, KH; Park, KY; Seo, SJ, 2015)	1.42
"Quercetin has a small beneficial effect for exercise of longer duration (>100 min), but it is unclear whether this benefits athletes."	( Impact of Dietary Antioxidants on Sport Performance: A Review. Braakhuis, AJ; Hopkins, WG, 2015)	1.14
"Quercetin, a flavonoid, has been tried in traditional medicine for treating many disorders and reported to have inhibitory action on PI3 kinase."	( Phosphatidylinositide 3-kinase inhibition: A new potential target for the treatment of polycystic ovarian syndrome. Patel, SS; Shah, KN, 2016)	1.88
"Quercetin has been reported to exhibit a wide range of biological activities related to their antibacterial activity and acetylcholine as a neurotransmitter, which can combine with the receptor on the bacterial cell."	( Investigation of functional selenium nanoparticles as potent antimicrobial agents against superbugs. Chen, Q; Chen, X; Huang, X; Liu, J; Sun, D; Yu, Q, 2016)	1.16
"Quercetin has potent anti-oxidative activities, but poor bioavailability limits its therapeutic application."	( Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway. Ding, SH; Hang, L; Xu, XR; Yang, XW; Yang, Y; Yu, HT, 2016)	2.6
"Quercetin has slightly affected it."	( Phloretin modulates the rate of channel formation by polyenes. Chulkov, EG; Ostroumova, OS, 2016)	1.16
"Quercetin also has known anti-inflammatory effects on lipopolysaccharide-induced macrophages."	( Anti-Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. Kim, YJ; Park, W, 2016)	1.45
"Quercetin has good potential to be applied in oral biological materials."	( [Inhibitory effect of quercetin on the biofilm formation of Streptococcus mutans]. Han, L; Huang, C; Song, FF; Yang, HY; Yue, JX; Zhu, MY, 2016)	1.47
"Quercetin has benefits for liver fibrosis, but the mechanisms are unknown."	( Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells. Fan, F; He, L; Hou, X; Wu, H, 2016)	2.6
"Quercetin has the special ability of scavenging highly reactive species, such as hydrogen peroxide, superoxide anion, and hydroxyl radicals."	( Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update. Abdollahi, M; Bishayee, A; Ismail Hassan, F; Khan, F; Maqbool, F; Nabavi, SM; Nagulapalli Venkata, KC; Niaz, K, 2016)	1.4
"Quercetin has multiple potential to control various cell function keeping our body condition healthy. "	( Quercetin is a Useful Medicinal Compound Showing Various Actions Including Control of Blood Pressure, Neurite Elongation and Epithelial Ion Transport. Hosogi, S; Ikeuchi, Y; Kanamura, N; Kashio, M; Kogiso, H; Marunaka, R; Marunaka, Y; Miyazaki, H; Nakahari, T; Nakajima, KI; Niisato, N; Okui, M; Sun, H; Taruno, A; Yamamoto, T, 2018)	3.37
"Quercetin has been reported to have the activities of antioxidant, anti-inflammatory, anti-virus, anti-cancer and so on. "	( Quercetin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in THP-1 macrophages. Jia, YP; Lu, Y, 2016)	3.32
"Quercetin has a substantial anticancer effect on various human cancer cells."	( Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Dong, X; Gu, H; Guo, S; Hisamitsu, T; Liu, Y; Qian, Y; Wang, H; Wang, M; Yang, L, 2016)	2.6
"Quercetin has also been well reported for its ability to reverse cognitive impairment and memory enhancement during aging."	( Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions. Braidy, N; Devi, KP; Nabavi, SF; Nabavi, SM; Suganthy, N, 2016)	1.47
"Quercetin has been identified as a promising compound with a neuroprotective potential against age-related neurodegenerative diseases such as Alzheimer's disease (AD). "	( Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer's disease. Irache, JM; Moreno, LCGEI; Puerta, E; Ramirez, MJ; Santos-Magalhães, NS; Suárez-Santiago, JE, 2017)	2.15
"Quercetin has a strengthening effect on the differentiation of rat bone marrow mesenchymal stem cells into β-cells and increases insulin secretion from the differentiated β-cells in vitro."	( Quercetin potentiates transdifferentiation of bone marrow mesenchymal stem cells into the beta cells in vitro. Khoshdel, Z; Miladpour, B; Mostafavipour, Z; Noorafshan, A; Owji, AA; Rasti, M; Zal, F, 2017)	3.34
"Quercetin has shown neuroprotective and antidiabetic effects, besides modulating cognition and insulin signaling."	( Quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male Swiss albino mice by attenuating insulin resistance and elevating hippocampal GLUT4 levels independent of insulin receptor expression. Mehta, V; Parashar, A; Sharma, A; Singh, TR; Udayabanu, M, 2017)	2.62
"Quercetin has a wide range of biological functions and health-promoting effects."	( Quercetin inhibits human sperm functions by reducing sperm [Ca2+]i and tyrosine phosphorylation. Liang, X; Wang, Y; Xia, Z; Xue, S; Yan, J; Zhang, X, 2016)	2.6
"Quercetin has been reported to have several biological activities, which include anti-viral and anti-inflammatory effects."	( The anti-HSV-1 effect of quercetin is dependent on the suppression of TLR-3 in Raw 264.7 cells. Cho, H; Kang, H; Lee, HH; Lee, S; Shin, YS, 2017)	1.48
"Quercetin has been shown to have anti-inflammatory properties and can play a role in anti-inflammatory procedure."	( Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways. Chen, L; Cheng, D; Fan, H; Hu, X; Liu, D; Lu, X; Song, X; Wang, T; Wei, Y; Wen, F; Xu, D; Yang, T; Ying, B, 2009)	2.52
"Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation."	( Quercetin regulates Th1/Th2 balance in a murine model of asthma. Ahn, SC; Chang, JH; Choi, IW; Chun, SH; Jeong, YI; Jung, ID; Kim, MJ; Lee, CM; Lee, JS; Park, HJ; Park, YM; Shin, YK; Yeom, SR, 2009)	2.52
"Quercetin has been shown to induce a progressive, dose-dependent and sustained reduction in blood pressure when given chronically in several rat models of hypertension, including spontaneously hypertensive rats, L-NAME-treated rats, DOCA-salt hypertensive rats, two-kidney one-clip Goldblatt rats, rats with aortic constriction and Dahl salt-sensitive hypertensive rats."	( Antihypertensive effects of the flavonoid quercetin. Duarte, J; Jimenez, R; Osuna, A; Perez-Vizcaino, F; Santos-Buelga, C, )	1.12
"Quercetin has strong antioxidant potency. "	( Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Crozier, A; Kawai, Y; Kumazawa, S; Matsui, A; Sakakibara, H; Shimoi, K; Terao, J; Yokoyama, A, 2009)	3.24
"Quercetin has been shown to possess beneficial pharmacological properties in treatment of heart disease, but lack of stability and bioavailability limits its clinical use. "	( 3,3',4',5,7-Pentamethylquercetin reduces angiotensin II-induced cardiac hypertrophy and apoptosis in rats. Du, X; Liang, Y; Mao, Z; Sun, Z, 2009)	2.11
"Quercetin has been shown to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of prostate cancer cells via mechanisms that include upregulation of death receptor (DR) 5, a protein reported to play an important role in sensitizing cancer cells to apoptosis. "	( Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5. Heo, J; Jung, YH; Kim, YH; Kwon, TK; Lee, YJ, 2010)	3.25
"Quercetin has been studied extensively. "	( Changes of metabolic profiles in urine after oral administration of quercetin in rats. An, D; Dong, F; Guo, C; Wei, J; Wu, S; Yan, X; Yang, J; Zhang, Q, 2010)	2.04
"Quercetin has been described as having a wide range of beneficial effects in humans, ranging from anti-carcinogenic properties to reducing the risk of CVD. "	( Quercetin supplementation and its effect on human monocyte gene expression profiles in vivo. Boomgaarden, I; Döring, F; Egert, S; Müller, MJ; Rimbach, G; Wolffram, S, 2010)	3.25
"Quercetin (Qt) has anti-inflammatory properties through its ability to inhibits nitric oxide production and iNOS expression in different cellular types."	( Quercetin tetraacetyl derivative inhibits LPS-induced nitric oxide synthase (iNOS) expression in J774A.1 cells. Cabrera, JL; Chiabrando, GA; Ortega, MG; Saragusti, AC, 2010)	2.52
"Quercetin has antioxidants properties which may increase nitric oxide (NO) bioavailability. "	( Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension. Castro, MM; Ceron, CS; Dias-Junior, CA; Gomes, VA; Kanashiro, A; Montenegro, MF; Neto-Neves, EM; Tanus-Santos, JE, 2010)	3.25
"Quercetin has been reported to be an efficient antioxidant which protects chicken spermatogonial cells from oxidative damage through increasing intracellular antioxidants and decreasing lipid peroxidation. "	( Quercetin protects hamster spermatogenic cells from oxidative damage induced by diethylstilboestrol. Li, G; Ma, A; Shi, W; Zhong, X, 2010)	3.25
"Quercetin has shown a biphasic behavior in basophils at nanomolar doses and hence its action on cells involved in allergic inflammation is here described."	( The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Chirumbolo, S, 2010)	1.46
"Quercetin has attracted much attention recently because of its antioxidant capacity and potential in the prevention of chronic degenerative diseases. "	( Cholesterol metabolism is modulated by quercetin in rats. Gao, W; Guo, C; Wang, Y; Wei, J; Wu, J; Yang, J; Zhao, L, 2011)	2.08
"Quercetin has generated considerable interest as a pharmaceutical compound with a wide range of therapeutic activities."	( Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis. Almeida-Amaral, EE; Canto-Cavalheiro, MM; Fonseca-Silva, F; Inacio, JD, 2011)	1.32
"Quercetin has been described as a pro-oxidant, generating ROS which are responsible for cell death in some cancer cells."	( Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis. Almeida-Amaral, EE; Canto-Cavalheiro, MM; Fonseca-Silva, F; Inacio, JD, 2011)	1.32
"1) Quercetin has a higher reduction potential compared with curcumin at three different pH settings and is comparable to Trolox at pH 7-9.5; 2) its TAC is 3.5 fold higher than curcumin; 3) it reduced LPS-induced ROS to near normal levels; 4) it reduced LPS-induced NO production. "	( Antioxidant properties of quercetin. Cao, Y; Howell, R; Ju, S; Keng, PC; Liu, C; Okunieff, P; Olek, DJ; Schwartz, L; Swarts, M; Swarts, SG; Tian, Y; Yang, S; Yin, L; Zhang, K; Zhang, L; Zhang, M; Zhang, SB, 2011)	1.29
"Quercetin has been shown to be an adenosine-receptor antagonist and may reduce oxidative stress via inhibition of the enzyme xanthine oxidase (XO)."	( Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation. Abbey, EL; Rankin, JW, 2011)	1.49
"Quercetin has potentially beneficial effects on disease prevention, including cancer. "	( The pro-apoptotic effect of quercetin in cancer cell lines requires ERβ-dependent signals. Acconcia, F; Bolli, A; Bulzomi, P; Galluzzo, P; Leone, S; Marino, M, 2012)	2.12
"Quercetin and rutin have been reported to exert numerous pharmacological activities, such as free-radical scavenging, effects on immune and inflammatory cell functions, and could have benefits in Alzheimer's disease (AD) by mitigating cellular damage induced by reactive oxygen species (ROS). "	( Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Benedí, J; Bermejo-Bescós, P; Jiménez-Aliaga, K; Martín-Aragón, S, 2011)	3.25
"Quercetin has an inhibitory effect on Aa and Pg."	( Inhibitory effect of quercetin on periodontal pathogens. Geoghegan, F; Rabie, AB; Tsui, VW; Wong, RW, 2008)	2.11
"Quercetin has been shown to induce apoptosis in a number of cancer cell lines, but a quercetin-loaded nanoliposomal formulation with enhanced antitumor activity in C6 glioma cells and its effect on cancer cell death has not been well studied. "	( Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death. Chen, JY; Du, SM; Feng, JB; Li, DS; Li, RM; Wang, G; Wang, JJ; Yang, GY; Ye, F; Yuan, SH; Zeng, N, 2012)	2.21
"Quercetin has been demonstrated to be effective in increasing physical endurance in mice and humans. "	( Quercetin alters energy metabolism in swimming mice. Gao, W; Guo, C; Pu, L; Wei, J; Wu, J; Yang, J, 2012)	3.26
"Quercetin has renal protective effects partly through reducing NF-κB p65 expression."	( [Effects of quercetin on nuclear factor-κB p65 expression in renal ubiquitin-proteasome system of diabetic rats]. Chen, JB; Chen, P; Chen, WY; Wang, YQ; Xu, XJ; Zheng, QL, 2012)	1.48
"Quercetin has also been shown to undergo oxidation."	( Rapid dimerization of quercetin through an oxidative mechanism in the presence of serum albumin decreases its ability to induce cytotoxicity in MDA-MB-231 cells. Bortolazzo, A; Pham, A; White, JB, 2012)	1.41
"Quercetin has been reported to protect testicular cells from oxidative damage induced by environmental chemicals. "	( Quercetin decreases steroidogenic enzyme activity, NF-κB expression, and oxidative stress in cultured Leydig cells exposed to atrazine. Abarikwu, SO; Farombi, EO; Pant, AB, 2013)	3.28
"Quercetin has therapeutic potential as an anticancer drug, but has poor solubility and low bioavailability."	( Co-encapsulation of biodegradable nanoparticles with silicon quantum dots and quercetin for monitored delivery. Ahire, J; Bao, Y; Chao, Y; Wang, Q, 2013)	1.34
"Quercetin has demonstrated protective effects against Aβ-induced toxicity on both neurons and endothelial cells. "	( Quercetin protects against the Aβ(25-35)-induced amnesic injury: involvement of inactivation of rage-mediated pathway and conservation of the NVU. Bai, XY; Du, GH; Huang, C; Li, L; Liu, R; Meng, FR; Song, JK; Wu, CX; Zhang, TT; Zhou, D; Zhou, WL, 2013)	3.28
"Quercetin has been reported to possess many important biological properties. "	( Quercetin modulates Na(+)/K(+) ATPase and sodium hydrogen exchanger in type 2 diabetic erythrocytes. Mishra, N; Rizvi, SI, 2012)	3.26
"Quercetin has antioxidant, anti-inflammatory, antiproliferative and anticarcinogenic properties. "	( Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase. Arts, IC; Faassen-Peters, M; Hollman, PC; Sesink, AL, 2003)	2.08
"Quercetin has been shown to act as a hyperthermia sensitizer by inhibiting the synthesis of heat shock protein 70 (HSP70) in a variety of tumour cell lines. "	( Quercetin sensitizes cells in a tumour-like low pH environment to hyperthermia. Bhala, A; Bobyock, SB; Burd, R; Leeper, DB; Owen, CS; Rifat, SB; Wachsberger, PR; Wahl, ML, )	3.02
"Quercetin has certain counter-effect against the influence of microgravity."	( [Image analysis of cardiac muscle cytoskeleton under simulated microgravity based on gray-level co-occurrence matrix (GLCM)]. Xiong, JH; Yan, H; Yao, YH, 2003)	1.04
"Quercetin has chemoprotective properties in experimental colon cancer models, and in vitro studies have demonstrated that quercetin inhibits HT-29 colon cancer cell growth. "	( Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. Bang, MH; Cho, HJ; Jung, KC; Kang, NE; Kim, ES; Kim, WK; Park, JH, 2005)	3.21
"Quercetin has been suggested to exert its pharmacological effects, at least in part, via its metabolites, such as glucuronides. "	( Quantitative regioselectivity of glucuronidation of quercetin by recombinant UDP-glucuronosyltransferases 1A9 and 1A3 using enzymatic kinetic parameters. Chen, SQ; Chen, YK; Li, X; Zeng, S, )	1.82
"Quercetin has therapeutic potential as an anti-cancer drug."	( Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells. Chang, YF; Chi, CW; Wang, JJ, 2006)	1.31
"Quercetin has many beneficial effects on the cardiovascular system, but it is unknown whether it provides protection against homocysteine-injured vascular endothelial cells."	( Protective effect of quercetin on the homocysteine-injured human umbilical vein vascular endothelial cell line (ECV304). Ding, C; Gan, W; Lin, R; Liu, J, 2007)	1.38
"Quercetin has provided increased preservation in myocardial recovery in both chronic and acute treatment protocols compared to non-treated group. "	( Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment. Dernek, S; Erkasap, N; Ikizler, M; Kaygisiz, Z; Kural, T, 2007)	2.11
"Quercetin has been shown to act as an anticarcinogen in experimental colorectal cancer (CRC). "	( Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. Alink, GM; Burgers, PC; Charif, H; de Boer, VC; Dekker, LJ; Dihal, AA; Hendriksen, PJ; Ijsselstijn, L; Rietjens, IM; Stierum, RH; van der Woude, H; Woutersen, RA, 2008)	2.03
"Quercetin has an antioxidant and anti-inflammatory activity and prevents cancer."	( Role of quercetin (a natural herbal compound) in allergy and inflammation. Caraffa, A; Castellani, ML; Cerulli, G; Conti, F; De Lutiis, MA; Madhappan, B; Perrella, A; Salini, V; Shaik, YB; Tete, S; Vecchiet, J, )	1.29
"Quercetin has an inhibitory effect on urinary crystal deposit formation."	( Reduction of oxidative stress in cultured renal tubular cells and preventive effects on renal stone formation by the bioflavonoid quercetin. Choi, EY; Jeong, BC; Kim, BS; Kim, HH; Kim, JI; Park, HK; Park, MY; Sung, MK, 2008)	1.99
"Quercetin aglycone has also been shown to modulate several signal transduction pathways involving MEK/ERK and Nrf2/keap1, which are associated with the processes of inflammation and carcinogenesis."	( Multitargeted cancer prevention by quercetin. Ashida, H; Murakami, A; Terao, J, 2008)	1.34
"Quercetin has been shown to inhibit antigen- and mitogen-induced histamine release from rat mast cells and basophils of subjects with hay fever, to increase cyclic adenosine monophosphate (AMP) in Ehrlich ascites tumor cells and to inhibit phosphodiesterase and certain adenosine triphosphatase (ATPase) systems."	( Quercetin inhibition of the induction and function of cytotoxic T lymphocytes. Middleton, E; Schwartz, A; Sutton, SL, 1982)	2.43
"Quercetin, which has a better than Ipriflavone water-solubility seems as promising as Ipriflavone in the control of the otosclerotic bone-remodelling disturbance."	( Flavonoids alter bone-remodelling in auditory ossicle organ cultures. Ribári, O; Sziklai, I, 1995)	1.01
"Quercetin has been the subject of numerous studies on its genetic toxicity and carcinogenicity. "	( On the mechanisms of genotoxicity and metabolism of quercetin. Costa, S; Gaspar, J; Laires, A; Monteiro, C; Monteiro, MJ; Rodrigues, A; Rueff, J; Silva, F, 1994)	1.98
"Quercetin has been shown to induce the translocation of tryptophanyls and tyrosyls from membrane protein inner regions to their surface."	( [Structural rearrangement in leukocyte membranes under the effect of quercetin and linoleic acid hydroxamate]. Lebed', OI; Luĭk, AI; Zhirnov, VV, )	1.09
"Quercetin has antiproliferative activity in vitro and is known to inhibit signal transduction targets including tyrosine kinases, protein kinase C, and phosphatidyl inositol-3 kinase."	( Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Anderson, D; Baker, J; deTakats, PG; Ferry, DR; Fyfe, DW; Kerr, DJ; Malkhandi, J; Smith, A, 1996)	1.28
"Quercetin, however, has a strong affinity for protein and provides no direct protective effect during LDL oxidation."	( Absorption and antioxidant effects of quercetin from onions, in man. McAnlis, GT; McEneny, J; Pearce, J; Young, IS, 1999)	1.3
"Quercetin has radical scavenging effects on both sides of the membrane, because it prevents PC-OOH production by AMVN or AAPH."	( [Effect of antioxidants on radical-initiated peroxidation of retinal homogenate]. Armstrong, D; Chida, M; Higa, A; Kan, K; Koide, R; Matsuishi, M; Suzuki, K; Ueda, T; Yamamoto, Y; Yasuhara, H, 2000)	1.03
"Quercetin has nonspecific effects on normal human T cells, but luteolin appears nontoxic."	( Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Bandyopadhyay, S; Chowdhury, AR; Majumder, HK; Mandal, S; Mittra, B; Mukhopadhyay, S; Pal, C; Saha, A, 2000)	1.03
"Quercetin has been reported to have carcinogenic effects. "	( Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin. Kawanishi, S; Yamashita, N, 2000)	1.99
"Quercetin has been known to have anti-tumor and anti-oxidation activities. "	( Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression. Saiki, I; Xu, Q; Zhang, X, 2000)	3.19
"Quercetin has been reported to be an agent that inhibits hsp70 expression."	( Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells. Deguchi, N; Hirata, R; Iida, M; Nakanoma, T; Ueno, M, 2001)	1.42
"Quercetin has been extensively studied in various short-term assays for genotoxicity. "	( Oxygen species and the genotoxicity of quercetin. Borba, H; Gaspar, J; Laires, A; Rodrigues, A; Rueff, J, 1992)	2
"Quercetin (Q) has been shown to inhibit Ca2+-dependent processes. "	( Selectivity of quercetin inhibition on stimulated amylase release in rat pancreatic acini. Cumella, JC; Lee, PC; Rossi, TM; Shimizu, K, 1988)	2.07

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Quercetin did not cause any significant changes on the plasma TC, TG and liver fat at weeks 4, 7 and 10. It did, however, inhibit ATPase activity of plasma membrane, suggesting that this unidentified ATPase may contribute to the formation of ADP and Pi required for lactate production by the intact cell.

Excerpt	Reference	Relevance
"Quercetin promotes the proliferation of H9C2 cells, while inhibiting inflammation, oxidative stress, and cell apoptosis, and alleviating the structural and functional dysfunction of mitochondria. "	( Quercetin regulates inflammation, oxidative stress, apoptosis, and mitochondrial structure and function in H9C2 cells by promoting PVT1 expression. Chen, H; Li, D; Li, F; Liu, J; Tang, S; Yan, J; Yan, X, 2021)	3.51
"Quercetin can inhibit glycolysis and cell proliferation of oral squamous cell carcinoma, apparently by inhibiting the G3BP1/YWHAZ axis."	( Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma. Chen, L; Hu, M; Song, HY, 2023)	3.07
"Quercetin and OC-20 inhibit airway inflammation response, airway fibrosis, and airway hyperreactivity."	( Quercetin Alleviates Asthma-Induced Airway Inflammation and Remodeling through Downregulating Periostin via Blocking TGF-β1/Smad Pathway. Fang, Y; Guo, Z; Hao, J; Jin, W, 2023)	3.07
"Quercetin plays a protective role in mouse A. "	( Quercetin protects against Aspergillus fumigatus keratitis by reducing fungal load and inhibiting TLR-4 induced inflammatory response. Lin, J; Luan, J; Peng, X; Tian, X; Xu, Q; Zhan, L; Zhang, Y; Zhao, G; Zhu, Y, 2023)	3.8
"Quercetin could inhibit the activity of CYP3A to down-regulate AA metabolites EETs, consequently hampering p-Stat3 and nuclear translocation, thus impeding BC development."	( Quercetin inhibits the metabolism of arachidonic acid by inhibiting the activity of CYP3A4, thereby inhibiting the progression of breast cancer. Fu, Q; Kuang, Y; Peng, B; Tang, H; Wu, W, 2023)	3.8
"Quercetin may lower the death rate from READ by targeting SLCO1B1 and producing enhanced effects from use of this compound, inhibiting cell growth, and inducing apoptosis in tumor cells."	( Prediction of new targets and mechanisms for quercetin in the treatment of pancreatic cancer, colon cancer, and rectal cancer. Jiang, C; Jin, H; Liu, Y; Lu, Y; Pang, B; Shao, D; Shi, J; Xu, X; Yang, R, 2019)	1.49
"Quercetin can inhibit the proliferation of primary leukemia cells in a time-dependent manner. "	( [Efficacy of Quercetin-sensitized Adriamycin for Treatment of Refractory Acute Leukemia]. DU, H; Han, YQ; Shi, YX; Su, XT, 2019)	2.33
"Quercetin can inhibit platelet apoptosis by increasing the ratio of apoptosis-related protein BCL-2/BAX in a concentration-dependent manner."	( [Effect of Quercetin on Apoptosis of Platelets and Its Mechanism]. Chen, XY; Jiang, LX; Jiang, YF; Ouyang, Q; Wu, YQ; Xiao, Q, 2019)	2.35
"Quercetin can inhibit the formation of foam cells induced by ox-LDL and delay senescence. "	( Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. Cao, H; Chen, C; Jia, Q; Shen, D; Xing, S; Yan, L, 2019)	3.4
"Quercetin was found to inhibit both AGEs production and amyloid formation."	( Non-enzymatic glycation of protein induces cancer cell proliferation and its inhibition by quercetin: Spectroscopic, cytotoxicity and molecular docking studies. Al-Okail, MS; AlAjmi, MF; Bhat, SA; Husain, FM; Khan, MS; Rehman, TM; Shaik, GM; Tabrez, S, 2021)	1.56
"Quercetin did not suppress HGF- or TGF-α-induced p38 MAPK phosphorylation."	( Quercetin suppresses the migration of hepatocellular carcinoma cells stimulated by hepatocyte growth factor or transforming growth factor-α: Attenuation of AKT signaling pathway. Kozawa, O; Matsushima-Nishiwaki, R; Yamada, N, 2020)	2.72
"Quercetin could increase the survival rate and proliferation rate of PC12 cells; reduce the levels of LDH, AChE, MDA, and HO-1 protein; and increase the levels of SOD, GSH-Px, CAT, T-AOC, sirtuin1, and Nrf2 protein."	( Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by A Li, Y; Mu, X; Yu, X, 2020)	1.68
"Quercetin can increase the survival rate of PC12 injured by A"	( Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by A Li, Y; Mu, X; Yu, X, 2020)	2.4
"Quercetin was shown to inhibit RANKL-mediated osteoclastogenesis, osteoblast apoptosis, oxidative stress and inflammatory response while promoting osteogenesis, angiogenesis, antioxidant expression, adipocyte apoptosis and osteoclast apoptosis."	( Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence. Chin, KY; Ima-Nirwana, S; Wong, SK, 2020)	2.72
"Quercetin can inhibit the proliferation of EESCs in adenomyosis and reduce their mobility and invasiveness. "	( Quercetin Inhibits Adenomyosis by Attenuating Cell Proliferation, Migration and Invasion of Ectopic Endometrial Stromal Cells. Li, K; Song, Y; Xu, W; Zhang, B; Zhu, X, 2020)	3.44
"Quercetin can inhibit gingipains, hemolytic, hemagglutination activities and biofilm formation at sub-MIC concentrations."	( Quercetin inhibits virulence properties of Porphyromas gingivalis in periodontal disease. Chang, H; He, Z; Li, L; Li, S; Song, Z; Zhang, X; Zhou, W, 2020)	2.72
"Quercetin might enhance the antitumor effect of cisplatin via inhibiting proliferation, migration and invasion and elevating apoptosis through weakening MMP2, ezrin, METTL3 and P-Gp expression of cancer cells."	( Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells. Chen, X; Pan, S; Qian, H; Xie, S; Xu, W; Zhu, X, 2021)	1.73
"Quercetin can increase the antioxidant capacity of PDLCs and reduce OS damage by activating the NRF2 signaling pathway, which alleviates alveolar bone loss in periodontitis."	( Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis. Fu, J; Ma, P; Ren, L; Wei, Y; Wu, J; Wu, W; Yi, Z, 2021)	3.51
"quercetins) from its flower petal."	( Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases. Adhikary, R; Bishayi, B; Sultana, S, 2018)	1.2
"Quercetin could inhibit the proliferation and promote the apoptosis of BIU-87 cells."	( [Mechanism in growth inhibition of quercetin on human bladder cancer cell line]. Liu, XH; Tan, DQ, 2017)	1.45
"Quercetin plays a protective role against intestinal barrier disruption and inflammation in ANP, probably partly by inhibiting TLR4/MyD88/p38 MAPK and ERS activation."	( Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition. Chunlan, H; Hui, X; Junjie, F; Junyuan, Z; Lihong, L; Qixiang, M; Xingpeng, W; Yingying, L; Yue, Z, 2018)	3.37
"Quercetin promotes HOKs proliferation and oral re-epithelialization in vitro."	( Effects of quercetin on human oral keratinocytes during re-epithelialization: An in vitro study. Chi, M; Hujiahemaiti, M; Li, C; Li, X; Lv, H; Qi, M; Sun, X; Zhou, J; Zhou, Y, 2018)	2.31
"Quercetin flavonoids inhibit PDI activity and block platelet accumulation and fibrin generation at the site of a vascular injury in mouse models, but the clinical effect of targeting extracellular PDI in humans has not been studied."	( Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer. Aggarwal, A; Bauer, KA; Caughey, T; Flaumenhaft, R; Furie, B; Hidalgo, M; Kuemmerle, N; Liebman, HA; McLaughlin, M; Neuberg, D; Puligandla, M; Schlechter, BL; Stopa, JD; Wong, E; Wun, T; Zwicker, JI, 2019)	1.48
"Quercetin was found to increase the number of proliferating neural stem/progenitor cells."	( Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus. Bagheri, HS; Ghanadian, M; Karimipour, M; Mahmoudi, J; Rahbarghazi, R; Shimia, M; Tayefi, H, 2019)	2.68
"Quercetin promotes the apoptosis of multiform glioblastoma U87 cells mediated by caspase-3 and influences the feedback balance of MDM2-p53."	( [Effect of quercetin on glioma cell U87 apoptosis and feedback regulation of MDM2-p53]. Chen, Z; Hu, Z; Wang, H; Wu, B; Yao, F; Yuan, Z, 2014)	2.23
"Quercetin also could increase p53 and Caspase-3 expression."	( Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells. Li, W; Tao, B; Zhang, Y; Zhao, Y, 2014)	1.51
"Quercetin could inhibit Hh signaling and its downstream targets in the KBM7 cells. "	( Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells. Li, W; Tao, B; Zhang, Y; Zhao, Y, 2014)	2.23
"Quercetin may inhibit HSP27 expression in PC-3 cell."	( [Effect of quercetin on heat shock protein 27 expression in prostate cancer cells]. Di, YC; Jiang, LL; Yu, F, 2014)	1.51
"Quercetin could activate caspase-3 and promote leukemic cell apoptosis."	( [Quercetin enhances the anti-leukemic effect of adriamycin]. Han, YQ; Hong, Y; Su, XL; Wang, JR, 2014)	2.03
"Quercetin can suppress osteosarcoma cell growth and metastasis. "	( Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA-217-KRAS Axis. Chen, J; Chen, Z; Guo, Q; Zhang, X, 2015)	3.3
"Quercetin also displays a different UV-protective effect depending on its location in the membranes, as the effect is more pronounced at pH 8.4 when it is located at the membrane surface."	( Damage and protection of the photosynthetic apparatus from UV-B radiation. II. Effect of quercetin at different pH. Apostolova, EL; Dobrikova, AG, 2015)	1.36
"Quercetin can inhibit cell viability and induce autophagy of U87 and U251 glioma cells in a dose-dependent manner."	( Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells. Bi, Y; Gao, D; Hou, X; Li, C; Liu, H; Liu, Y; Liu, Z; Peng, F; Shen, C; Shi, C; Wang, K; Wang, X; Wu, J; Zhang, J; Zhao, B; Zhao, S; Zheng, Z; Zhong, C; Zou, H, 2016)	1.43
"Quercetin acts to increase survival in the face of ischemia via an increase of SENP3 expression, the possible inactivation of SENPs 1/2, and via a decrease in KEAP1 levels (thereby increasing Nrf2 stability)."	( Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose. Bernstock, JD; Hallenbeck, JM; Ko, B; Lee, YJ; Nagaraja, N, 2016)	1.39
"Quercetin could inhibit Ang II induced apoptosis of human umbilical vein endothelial cells via the mitochondrial pathway."	( Quercetin inhibits angiotensin II induced apoptosis via mitochondrial pathway in human umbilical vein endothelial cells. Guo, BB; Jia, YP; Lu, Y; Wang, RH, 2016)	3.32
"Quercetin prevented the increase in total plasma cholesterol, but only partially prevented the high cholesterol diet-induced alterations in lipid profile."	( The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies. Borges, K; Carrasco-Pozo, C; Cires, MJ; De La Jara, N; Garcia-Diaz, DF; Llanos, P; Ngo, ST; Reyes-Farias, M; Tan, KN, 2016)	1.4
"Quercetin could increase ABCA1 expression and cholesterol efflux through LXRα pathway to eventually promote RCT in the THP-1 macrophage."	( Quercetin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in THP-1 macrophages. Jia, YP; Lu, Y, 2016)	3.32
"Quercetin (Qe) plays an important role in inflammation, antibacterial, anticancer, and aging. "	( Quercetin loading CdSe/ZnS nanoparticles as efficient antibacterial and anticancer materials. Cai, Y; Li, N; Lin, Y; Mou, Z; Sun, D; Wang, W; Yang, X; Zhang, W; Zhao, Z, 2017)	3.34
"Quercetin did not cause cytotoxicity 24 h after treatment."	( Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells. Habel, A; Rami, A; Reuss, DE; Siegelin, MD; von Deimling, A, 2009)	2.52
"Quercetin can enhance the inhibitory effect of cisplatin on HeLa cell adhesion, migration and invasion."	( [Effects of quercetin and quercetin in combination with cisplatin on adhesion, migration and invasion of HeLa cells]. Chen, XM; Luo, RY; Zhang, FL; Zhang, W, 2008)	1.45
"Quercetin can inhibit breeding of HeLa cells and induce apoptosis of the cells. "	( Effects of quercetin on proliferation, apoptosis, adhesion and migration, and invasion of HeLa cells. Zhang, F; Zhang, W, 2009)	2.19
"Quercetin plays a cardiovascular protective role because of its antioxidant capacity and ability to modulate dyslipidemia. "	( Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cells. Gnoni, GV; Paglialonga, G; Siculella, L, 2009)	3.24
"The quercetin-induced increase and nuclear translocation of HIF-1alpha was reversed by addition of excess iron (100 microM)."	( Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Kroon, PA; Mithen, RF; Radreau, P; Rhodes, JD; Sanderson, J, 2009)	1.08
"Quercetin did not increase reactive oxygen species generation but increased cytosolic Ca(2+) levels and reduced the mitochondrial membrane potential (DeltaPsi(m))."	( Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Chen, DR; Chien, SY; Chung, JG; Kuo, SJ; Lu, HF; Tsou, MF; Wood, WG; Wu, YC; Yang, JS, 2009)	2.52
"Quercetin may allow for dissection of the viral life cycle and has potential therapeutic use to reduce virus production with low associated toxicity."	( The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Arumugaswami, V; Dasgupta, A; Fontanes, V; French, SW; Gonzalez, O; Loo, J; Loo, R; Raychaudhuri, S; Sun, R, 2009)	2.08
"Quercetin was found to enhance the photostability of the two UV filters in a concentration-dependent way."	( Photostabilization effect of quercetin on the UV filter combination, butyl methoxydibenzoylmethane-octyl methoxycinnamate. Mezzena, M; Scalia, S, )	1.14
"Quercetin plays a very important role in ameliorating reproductive toxicity induced by environmental oestrogens."	( Quercetin protects hamster spermatogenic cells from oxidative damage induced by diethylstilboestrol. Li, G; Ma, A; Shi, W; Zhong, X, 2010)	2.52
"Quercetin is known to inhibit tyrosinase activity and melanin production in melanocytes. "	( Quercetin inhibits α-MSH-stimulated melanogenesis in B16F10 melanoma cells. Jeon, YM; Lee, JC; Lee, SA; Son, YO; Yang, YM, 2011)	3.25
"Quercetin can inhibit the proliferation and induce the apoptosis of human PC-3 cells, but its action mechanism remains to be further investigated."	( [Quercetin induces the apoptosis of human PC-3 cells]. Gu, XJ; Hu, R; Huang, WZ; Liu, L; Ma, L; Yuan, L; Zhu, QY, 2011)	2.72
"Quercetin could inhibit the Proliferation of MGC-803 cells. "	( [Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway]. Chen, Y; He, LY; Qin, Y; Wang, WY; Wu, MY; Zhao, XH, 2012)	2.73
"Quercetin was found to inhibit basal and insulin-induced phosphorylation of Akt (Ser473), a downstream target of PI3K, in HT-22 cells, whereas naringenin and curcumin had no effect."	( The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling. Ganjam, GK; Heldmaier, G; Hoggard, N; Koch, CE; Legler, K; Schumacher, D; Steger, J; Stöhr, S; Tups, A, 2013)	1.38
"Quercetin was found to suppress proliferation of human HCC cell lines BEL-7402, HuH-7 and HLE, with peak suppression at 50 micromol/L quercetin. "	( Synergetic anticancer effect of combined quercetin and recombinant adenoviral vector expressing human wild-type p53, GM-CSF and B7-1 genes on hepatocellular carcinoma cells in vitro. Shi, M; Wang, FS; Wu, ZZ, 2003)	2.03
"Quercetin was found to inhibit several important steps of angiogenesis including proliferation, migration, and tube formation of human microvascular dermal endothelial cells in a dose-dependent manner."	( Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Ding, J; Li, MH; Lin, LP; Tan, WF; Tong, YG; Xiao, D; Zhang, YX, 2003)	2.48
"Quercetin was found to inhibit H(2)O(2)- or xanthine (X)/xanthine oxidase (XO)-induced oxidative neuronal cell injury, with an estimated IC(50) of 4-5 micro g/ml."	( Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Cho, J; Dok-Go, H; Jin, C; Kim, HJ; Lee, EH; Lee, J; Lee, KH; Lee, YH; Lee, YS; Song, YS, 2003)	1.29
"4. Quercetin did not inhibit glucose transport into cells but decreased intracellular sequestration of [5-(3)H]glucose under conditions of net glucose release."	( Action of quercetin on glycogen catabolism in the rat liver. Bracht, A; Bracht, L; Constantin, J; Gasparin, FR; Ishii-Iwamoto, EL; Salgueiro-Pagadigorria, CL, 2003)	1.24
"Quercetin can inhibit the growth of transplantation tumor of breast cancer cell line MCF-7 in nude mice."	( [Effects of quercetin on the proliferation and apoptosis in transplantation tumor of breast cancer in nude mice]. He, S; Kong, L; Ma, S; Wu, K; Zhong, X, 2003)	2.14
"Quercetin-induced increase in nociceptive threshold was reversed by naloxone (2 mg/kg i.p.), an opioid receptor antagonist."	( Quercetin, a bioflavonoid, attenuates thermal hyperalgesia in a mouse model of diabetic neuropathic pain. Anjaneyulu, M; Chopra, K, 2003)	2.48
"Quercetin can inhibit the intestinal movement and reduce capillary permeability in the abdominal cavity, which may be the antidiarrheal mechanism of Psidium guajava L extract."	( [Mechanism of quercetin as an antidiarrheal agent]. Chen, BT; Mo, ZX; Wang, CY; Zhang, WJ; Zhu, QH, 2003)	2.12
"Quercetin at lower doses was found to be more effective."	( Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats. Mahesh, T; Menon, VP, 2004)	2.49
"Quercetin (QU) displays antioxidant and cell protective effects in most cell culture models, yet in some studies it is reported that QU shows prooxidant and cytotoxic effects. "	( Coadjustment of quercetin and hydrogen peroxide: the role of ROS in the cytotoxicity of quercetin. Chen, J; Da, WM; Kang, JH; Ou, YX, 2004)	2.11
"Quercetin inhibited the increase of tartrate-resistant acid phosphatase (TRAP) activity of mononuclear preosteoclasts (pOCs) induced by receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL) in both MD and RAW cell cultures."	( Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Hagiwara, H; Lee, IS; Nagai, K; Nakagawa, H; Notoya, M; Ohnishi, M; Udagawa, N; Woo, JT; Yonezawa, T, 2004)	2.49
"Quercetin can enhance acyclovir intestinal absorption by inhibiting the function of P-gp."	( [Effect of quercetin on the acyclovir intestinal absorption]. Li, XD; Lv, WL; Meng, H; Yang, ZG; Zhang, Q; Zhang, X, 2004)	2.16
"Quercetin induces an increase followed by a decrease in |DeltaPsim| value depending on its concentration."	( Spontaneous mitochondrial membrane potential change during apoptotic induction by quercetin in K562 and K562/adr cells. Dechsupa, S; Kothan, S; Leger, G; Mankhetkorn, S; Moretti, JL; Vergote, J, 2004)	1.27
"Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3'-sulfate had no effect."	( Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Chen, CP; Chen, JC; Ho, FM; Hsu, HB; Jeng, KC; Lee, ST; Lin, WW, 2005)	1.32
"Quercetin did not activate transcription through p53-binding sites in HeLa cells, although it up-regulated gadd45 in p53-inactivated tumor cells."	( Quercetin induces gadd45 expression through a p53-independent pathway. Horinaka, M; Maeda, A; Nakata, S; Sakai, T; Shiraishi, T; Wakada, M; Yogosawa, S; Yoshida, T, 2005)	2.49
"Quercetin can inhibit the growth and induce apoptosis of MGC-803 cells in a dose- and time-dependent manner. "	( [Quercetin inhibits growth and induces apoptosis of human gastric carcinoma cells]. Chen, Y; Cheng, CL; Guo, LM; He, LY; Wang, HY; Wu, MY; Zhao, XH, 2006)	2.69
"Quercetin was found to increase osteogenic differentiation in a dose-dependent manner."	( Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Bae, YC; Jung, JS; Kim, YJ; Suh, KT, 2006)	2.5
"Quercetin-induced increase in cAMP-stimulated progesterone secretion was reversed by ICI 182,780, an estrogen receptor (ER) antagonist."	( Effects of genistein, resveratrol, and quercetin on steroidogenesis and proliferation of MA-10 mouse Leydig tumor cells. Chen, YC; Lin, T; Nagpal, ML; Stocco, DM, 2007)	1.33
"Quercetin did not inhibit and rather enhanced 0.1 mM H2O2-induced cell death."	( Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation. Horie, S; Kashiwayanagi, M; Murayama, T; Nakamura, H; Saito, T; Sasaki, M; Tsuchiya, S, 2007)	2.5
"Quercetinases catalyze the 2,4-dioxygenolytic cleavage of 3,5,7,3',4'-pentahydroxyflavone to 2-protocatechuoylphloroglucinol carboxylic acid and carbon monoxide."	( A new monocupin quercetinase of Streptomyces sp. FLA: identification and heterologous expression of the queD gene and activity of the recombinant enzyme towards different flavonols. Fetzner, S; Merkens, H; Rose, K; Sielker, S, 2007)	1.41
"Quercetin was shown to produce hydrogen peroxide in aqueous solutions at pH 7.5, this resulting in the oxidation of the cysteine residues of the enzyme."	( Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase. Firuzi, O; Muronetz, VI; Saso, L; Schmalhausen, EV; Shalova, IN; Zhlobek, EB, 2007)	1.33
"Quercetin was able to inhibit the ecto-5'-NT/CD73 activity and modulate its expression."	( Ecto-5'-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line. Battastini, AM; Bernardi, A; Braganhol, E; Tamajusuku, AS; Wink, MR, 2007)	1.33
"Quercetin was found to inhibit HSP expression depleting heat shock factor 1 (HSF1) cellular stores."	( Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing's sarcoma cell lines. Bisaro, B; Carta, F; Crescenzio, N; di Montezemolo, LC; Doria, A; Foglia, L; Giribaldi, G; Mandili, G; Timeus, F; Turrini, F; Zanini, C, 2007)	1.31
"Quercetin did not increase reactive oxygen species (ROS) generation and the quercetin-induced cell death was also not affected by antioxidants, suggesting that ROS generation is not involved in loss of cell viability."	( Underlying mechanism of quercetin-induced cell death in human glioma cells. Choi, CH; Kang, SK; Kim, EJ; Kim, YK; Park, JY, 2008)	1.37
"Quercetin can activate the expression of Caspase-3 and induce the apoptosis of HEN1 cells through mitochondrion-depended pathway."	( [Effect of quercetin on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells]. Cao, P; Cui, Y; Zhang, F, 2007)	2.17
"Quercetin seems to inhibit the transcription by interaction with the enzyme."	( Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. Nose, K, 1984)	0.99
"Quercetin was found to inhibit hsp70 synthesis for a period of 3-6 h after PGA1 treatment."	( Modulation of prostaglandin A1-induced thermotolerance by quercetin in human leukemic cells: role of heat shock protein 70. Amici, C; Elia, G; Rossi, A; Santoro, MG, 1996)	1.26
"The quercetin-induced increase in Isc was inhibited by the Cl- channel blocker 5-nitro-2-(3-phenylpropylamino)-benzoic acid."	( Dietary flavonol quercetin induces chloride secretion in rat colon. Cermak, R; Föllmer, U; Wolffram, S, 1998)	1.12
"Quercetin induced an increase in short-circuit current (Isc), which was largely independent of submucosal neurons, as it was not affected by the neurotoxin tetrodotoxin."	( The secretory response of the rat colon to the flavonol quercetin is dependent on Ca2+-calmodulin. Cermak, R; Kuhn, G; Vujicic, Z; Wolffram, S, 2000)	1.27
"Quercetin failed to increase Luc activity in cells transfected with a reporter vector containing a mutated ARE."	( Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Kepa, JK; Pickwell, GV; Quattrochi, LC; Valerio, LG, 2001)	1.25
"Quercetin and tamoxifen inhibit melanoma cell growth."	( Quercetin and tamoxifen sensitize human melanoma cells to hyperthermia. Castrilli, G; Larocca, LM; Maggiano, N; Natali, PG; Piantelli, M; Ranelletti, FO; Savini, F; Tatone, D, 2001)	2.47
"Quercetin inhibited an increase of hsp70 expression after heat treatment and increased the number of subG1 cells with lower levels of hsp70 in JCA-1 and LNcap cells."	( Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells. Deguchi, N; Hirata, R; Iida, M; Nakanoma, T; Ueno, M, 2001)	1.42
"Quercetin did not cause tumors at other sites."	( Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Dunnick, JK; Hailey, JR, 1992)	1.27
"Quercetin did not increase the thermosensitivity of non-tolerant cells."	( Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line. Abe, M; Hiraoka, M; Hirayoshi, K; Hosokawa, N; Koishi, M; Nagata, K; Nakai, A; Sato, M, 1992)	2.45
"Quercetin did not cause any significant changes on the plasma TC, TG and liver fat at weeks 4, 7 and 10."	( Effects of polyphenolic natural products on the lipid profiles of rats fed high fat diets. Das, NP; Tan, BK; Teh, M; Yugarani, T, 1992)	1
"Quercetin may inhibit the promotive effect of the NP on histamine release and the secretion of the NP while ketotifen and isoproterenol have no influence on this promotive effect."	( [Effects of neutrophils on histamine release from mast cells]. Bian, RL; Wang, YC; Zhou, HL, 1990)	1
"Quercetin did, however, inhibit ATPase activity of plasma membrane, suggesting that this unidentified ATPase may contribute to the formation of ADP and Pi required for lactate production by the intact cell."	( Motility, heat, and lactate production in ejaculated bovine sperm. Hammerstedt, RH; Racker, E; Volonté, C, 1988)	1

Treatment

Quercetin pretreatment could antagonize such machinery to protect the kidney against DEP. QuercetIn and vitamin E treatment reversed these effects, suggestive of their anti-apoptotic effect.

Excerpt	Reference	Relevance
"Quercetin pretreatment could antagonize such machinery to protect the kidney against DEP."	( The biomechanistic aspects of renal cortical injury induced by diesel exhaust particles in rats and the renoprotective contribution of quercetin pretreatment: Histological and biochemical study. Alasmari, WA; Faruk, EM; Fouad, H; Morsi, AA, 2022)	1.65
"Quercetin pretreatment attenuated the acquisition and reinstatement. "	( Evaluation of the effects of quercetin on the rewarding property of ethanol in mice. Yunusoğlu, O, 2022)	2.46
"Quercetin pretreatment alleviated reactive oxygen species generation, NF-"	( Quercetin Prevents Radiation-Induced Oral Mucositis by Upregulating BMI-1. Dong, Q; Dong, X; Feng, Y; Hong, Y; Jiang, Z; Li, H; Liu, H; Liuyang, Z; Tao, J; Wang, G; Wang, Y; Xie, A; Zhang, J, 2021)	2.79
"Quercetin and vitamin E treatment reversed these effects, suggestive of their anti-apoptotic effect."	( Quercetin and vitamin E ameliorate cardio-apoptotic risks in diabetic rats. Obaidu, IM; Obigade, OC; Ojo, OO; Olorunsogo, OO, 2022)	2.89
"Quercetin treatment helps to prevent oxidative damage and neuroinflammation in LPS treated adult zebrafish."	( Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish. Kapil, L; Sahu, K; Singh, A; Singh, C; Singh, S, 2022)	3.61
"The quercetin-EGCG co-treatment reduced glucose production through targeting FOXO1 and inhibiting the transcription of gluconeogenic enzymes."	( Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96-5p. Guan, H; Jiang, Y; Li, D; Li, F; Liu, H; Sun-Waterhouse, D; Tan, X, 2022)	1.42
"Post quercetin treatment improved liver function parameters in the hepatotoxic Wistar rats by augmenting bilirubin content, SGOT and SGPT activity."	( Nonlinear molecular dynamics of quercetin in Gynocardia odorata and Diospyros malabarica fruits: Its mechanistic role in hepatoprotection. Alkahtani, S; Baishya, D; Ghosh, A; Mishra, R; Mukerjee, N; Patel, H; Sarmah, P; Varma, RS, 2022)	1.46
"Quercetin co-treatment enhanced activities of antioxidant enzymes, inhibited myeloperoxidase (MPO) activity, lowered levels of nitric oxide, interferon-Υ (IFN-Υ), and interleukin-6 (IL-6), and reduced kynurenine concentration as well as IDO/TDO activities."	( Abatement of cyclophosphamide-induced splenic immunosuppressive indoleamine 2, 3-dioxygenase and altered hematological indices in Wister rats by dietary quercetin. Kalu, WO; Olachi Obasi, D; Peter Ebokaiwe, A, 2022)	1.64
"Quercetin treatment decreases NOX expression and thus exerts antioxidant and anti-inflammatory effects in the Achilles tendons of diabetic rats. "	( Quercetin treatment protects the Achilles tendons of rats from oxidative stress induced by hyperglycemia. Inui, A; Kuroda, R; Mifune, Y; Mukohara, S; Nishimoto, H; Shinohara, I; Yamaura, K; Yoshikawa, T, 2022)	3.61
"Quercetin treatment also significantly reduced the increased serum leptin (LP) levels in NOD/Ltj mice."	( Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB-R signaling. Chang, L; Chen, P; Guo, Y; Kong, A; Sun, Y; Wang, X; Zhang, J, 2022)	2.89
"Quercetin pretreatment alleviates seizure-like behaviors and cognitive impairment in KA-induced epileptic mice."	( Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway. Bentley, R; Hu, G; Jiang, X; Lowe, S; Mei, H; Sun, C; Wu, Y; Xie, R; Zhao, W, 2022)	2.89
"Quercetin treatment also restored the increased expression of GFAP and decreased expression of occludin and doublecortin in the frontal cortex and hippocampus of rmTBI mice."	( Involvement of Microbiome Gut-Brain Axis in Neuroprotective Effect of Quercetin in Mouse Model of Repeated Mild Traumatic Brain Injury. Balasubramanian, R; Bazaz, MR; Dandekar, MP; Pasam, T; Samanthula, G; Sharief, N; Velip, L, 2023)	1.87
"Quercetin (40 mg/kg) treated improved some behavioral disorders."	( Preventive effect of quercetin-Loaded nanophytosome against autistic-like damage in maternal separation model: The possible role of Caspase-3, Bax/Bcl-2 and Nrf2. Eslami, A; Hasantabar, V; Jelodar, SK; Moghaddam, AH; Ranjbar, M, 2023)	1.95
"Quercetin-pretreated mice significantly reduced radiation-induced DNA damage and intestinal epithelium cell apoptosis."	( Quercetin Mitigates Radiation-Induced Intestinal Injury and Promotes Intestinal Regeneration via Nrf2-Mediated Antioxidant Pathway1. Li, J; Li, Y; Liu, Y; Wu, L; Xu, Y; Yang, M; Yu, Z; Yue, L; Zhang, B; Zhang, Y; Zhou, X; Zhu, X, 2023)	3.07
"Quercetin-treated groups were treated with intragastric quercetin once a day for 28 days."	( Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades. Gu, J; Hao, B; Hong, W; Jaspers, RT; Lan, H; Li, H; Pathak, JL; Peng, G; Qian, D; Shao, M; Wang, H; Wu, G; Yan, Y; Zeng, J, 2023)	3.07
"Quercetin treatment inhibits MPEs-induced oxidative testicular damage in rats possibly by direct scavenging of free radicals to lower testicular oxidative stress and restore the regulation of the Nrf2 signaling pathway."	( [Mechanisms mediating the inhibitory effects of quercetin against phthalates-induced testicular oxidative damage in rats]. Deng, R; Gao, H; Lin, M; Liu, L; Xia, L; Zhou, W, 2023)	2.61
"Quercetin treatment reversed the molecular, functional and morphological abnormalities brought on due to letrozole in pathological and physiological setting, particularly the issues of reproduction connected to PCOS. "	( Effect of quercetin on steroidogenesis and folliculogenesis in ovary of mice with experimentally-induced polycystic ovarian syndrome. Al-Jafary, MA; Al-Qhtani, MH; Al-Suhaimi, EA; Ansari, MA; Bashir, SM; Ganie, MA; Homeida, AM; Mir, MA; Rather, GA; Shafi, M; Shah, MZUH; Sheikh, WM; Shrivastva, VK, 2023)	2.76
"Quercetin treatment markedly suppressed amiodarone induced toxicity in the pulmonary tissues."	( Pulmonary Responses Following Quercetin Administration in Rats After Intratracheal Instillation of Amiodarone. Oka, VO; Okon, UE; Osim, EE, 2019)	1.52
"Quercetin treatment is suggested to reduce the risk factors for obesity."	( Quercetin Actions on Lipid Profiles in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis. Gong, X; Guo, W; Li, M, 2019)	2.68
"Quercetin treatment suppressed body weight gains and reduced the extent of atherosclerotic lesions in the aortic sinus."	( Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites. Du, X; Nie, J; Zhang, L; Zhao, G, 2019)	2.68
"Oral quercetin treatment may represent a new approach to mitigating the onset and development of atherosclerosis."	( Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites. Du, X; Nie, J; Zhang, L; Zhao, G, 2019)	2.47
"Quercetin treatment attenuated rotenone- and iron supplement-induced motor deficits and biochemical and neurotransmitter alterations in experimental rats."	( Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement-Induced Parkinson's Disease in Experimental Rats. Raj, K; Sharma, S; Singh, S, 2020)	1.58
"Quercetin treatment alleviated necroptosis of OLs partially by inhibiting M1 macrophages/microglia polarization after SCI. "	( Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats. Chen, X; Chen, Z; Fan, H; Hao, DJ; Huang, DG; Liu, SC; Shan, LQ; Tang, HB; Yang, H; Yang, M; Yin, XH, 2019)	3.4
"Quercetin treatment attenuated the increase of caspase-3."	( Quercetin Reduces Ischemic Brain Injury by Preventing Ischemia-induced Decreases in the Neuronal Calcium Sensor Protein Hippocalcin. Jeon, SJ; Kang, JB; Koh, PO; Park, DJ, 2020)	2.72
"Quercetin treatment led to significantly higher levels of p-PI3K, p-AKT, p-JAK1, and p-STAT3."	( Quercetin protects human oral keratinocytes from lipopolysaccharide-induced injury by downregulating microRNA-22. Ke, Y; Wang, F; Wang, FJ; Yang, L, 2020)	2.72
"Quercetin treatment also resulted in reduced nuclear beta-catenin and reduced Pax2 expression."	( Quercetin treatment reduces the severity of renal dysplasia in a beta-catenin dependent manner. Ask, A; Bridgewater, D; Cunanan, J; Cunanan, K; Deacon, E; Morikawa, L; Todorova, E; Yang, Z, 2020)	2.72
"Quercetin treatment also decreases Bcl-2 and increases Bax protein expression, and increases miR-197 mRNA while reducing IGFBP5 mRNA expression."	( Quercetin induces apoptosis in meningioma cells through the miR-197/IGFBP5 cascade. Cheng, J; Hu, SA; Zhao, HY; Zhao, WH, 2020)	2.72
"Quercetin treatment reversed these effects."	( Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Chen, X; Liu, T; Qin, R; Shan, W; Yang, Q; Zhang, H; Zhang, X, 2020)	2.72
"Quercetin treatment also inhibited the expression of COX-2 and hypoxia-inducible factor 1"	( Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1 Chen, J; Jing, H; Liu, X; Luo, L; Qin, T; Shen, Z; Wang, L; Wu, H; Xiong, L; Yang, N; Zhu, X, 2020)	2.72
"Quercetin treatment increased the expressions of IL-10, VEGF, TGF-β"	( Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors. Jangir, BL; Kant, V; Kumar, V; Nigam, A; Sharma, V, 2020)	2.72
"Quercetin pretreatment ameliorates DMH-induced proliferation, activities of detoxifying enzymes, and putative early markers (mucin depletion and goblet cell disintegration) in colonic tissue."	( Quercetin ameliorates reactive oxygen species generation, inflammation, mucus depletion, goblet disintegration, and tumor multiplicity in colon cancer: Probable role of adenomatous polyposis coli, β-catenin. Islam, J; Shree, A; Sultana, S, 2021)	2.79
"Quercetin-treatment decreased the sharp increase in RNA expression of BAX and MPO in both cisplatin-toxicated testes and after MNU carcinogenesis induction."	( Efficacy of Quercetin-Sensitized Cisplatin against N-Nitroso-NMethylurea Induced Testicular Carcinogenesis in Wistar Rats. El-Diasty, HH; El-Ghaweet, HA; El-Sayyad, H; Refaat, S, 2021)	1.72
"Quercetin treatment at 50 μM and 75 μM concentration inhibit human metastatic ovarian cancer PA-1 cell survival and proliferation via inactivating PI3k/Akt, Ras/Raf pathways and EGFR expression."	( Quercetin attenuates metastatic ability of human metastatic ovarian cancer cells via modulating multiple signaling molecules involved in cell survival, proliferation, migration and adhesion. Arunakaran, J; Dhanaraj, T; Mohan, M, 2021)	2.79
"Quercetin treatment attenuated cortical inflammatory responses and oxidative stress induced by TBI insults."	( Protective effects of quercetin on traumatic brain injury induced inflammation and oxidative stress in cortex through activating Nrf2/HO-1 pathway. Cui, S; Du, G; Gao, X; Liu, B; Song, J; Wu, H; Yang, Z, 2021)	1.66
"Quercetin pretreatment partially alleviated the decrease of cell viability, the increase of apoptosis, and the release of inflammatory cytokines (IL-10, IL-6, and IL-17A) induced by TNF-α."	( Quercetin Efficiently Alleviates TNF-α-Stimulated Injury by Signal Transducer and Activator of Transcription 1 and Mitogen-Activated Protein Kinase Pathway in H9c2 Cells: A Protective Role of Quercetin in Myocarditis. An, Y; Li, S; Yang, B; Zhang, R; Zhao, C; Zheng, CY, 2021)	2.79
"Quercetin treatment significantly reduced cell viability in two GBM cell lines of U87MG and U373MG while keeping 85% of normal astrocytes alive."	( Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway. Choi, YJ; Kim, HI; Kim, MJ; Kim, TY; Ko, SG; Lee, SJ, 2021)	2.79
"All quercetin-treated rats had a daily single dose of 25, 50 or 100 mg/kg intraperitoneally administered quercetin for 21 days, and the last dose was given 30 min before the penicillin injection."	( Chronic effects of different quercetin doses in penicillin-induced focal seizure model. Aygun, H; Sumbul, O, 2021)	1.39
"Quercetin pretreatments of 25, 50 and 100 mg/kg significantly increased the duration of latency (initial spike activity) and decreased spike frequency of the epileptiform activity compared to the control group (p < 0.05). "	( Chronic effects of different quercetin doses in penicillin-induced focal seizure model. Aygun, H; Sumbul, O, 2021)	2.36
"Quercetin treatment increased mitochondrial biogenesis, caused hypertrophy in pancreatic β cells and activated mTOR signaling with a transient change in mitochondrial membrane potential and AMP/ATP."	( Quercetin improves oxidative stress-induced pancreatic beta cell alterations via mTOR-signaling. Dhanya, R; Kartha, CC, 2021)	2.79
"Quercetin treatment in the GBH+Quer group allowed partial or total improvement in behavioral tests (EPM and FST) and in the levels of oxidative stress markers (RS and GSH)."	( A subchronic low-dose exposure of a glyphosate-based herbicide induces depressive and anxious-like behavior in mice: quercetin therapeutic approach. Bicca, DF; Cibin, FWS; Ramalho, JB; Soares, MB; Spiazzi, CC, 2021)	1.55
"Quercetin treatment protects bladder tissue contractility against acute I/R injury by decreasing oxidative stress and apoptosis induced by I/R."	( Antioxidant Agent Quercetin Prevents Impairment of Bladder Tissue Contractility and Apoptosis in a Rat Model of Ischemia/Reperfusion Injury. Cadirci, S; Cetinel, S; Cevik, O; Sener, G; Sener, TE; Tarcan, T; Tinay, I; Toklu, H, 2017)	2.23
"Quercetin treatment reduced aging-induced morphological changes and reactive oxygen species accumulation."	( Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPF activity. Jo, YJ; Kim, NH; Oh, JS; Wang, H, 2017)	2.62
"Quercetin treatment also induced apoptosis via deregulating the expression of apoptotic genes, including Bax and Bcl-2, and arrested cell cycle at G2/M phases."	( Effects of quercetin on proliferation and migration of human glioblastoma U251 cells. Li, CL; Lin, Y; Liu, Y; Lv, W; Qu, XG; Tang, ZG; Wang, GB, 2017)	1.57
"The quercetin treated with the plasma for 20 min showed rapidly increased α-glucosidase inhibitory and radical scavenging activities compared to those of parent quercetin."	( Plasma-Induced Degradation of Quercetin Associated with the Enhancement of Biological Activities. Jo, C; Kim, HJ; Kim, TH; Lee, J, 2017)	1.22
"Quercetin treatment significantly improvement stress-mediated behavior dysfunction as indicated by improved locomotion, lesser immobility time and greater frequency of upward turning in TST and FST and increased transfer latency on the day 2 (short-term memory) and day 5 (long-term memory) in PASD test."	( Quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male Swiss albino mice by modulating hippocampal insulin signaling pathway. Mehta, V; Singh, TR; Udayabanu, M, 2017)	2.62
"Quercetin treatment reduced the lipid peroxidation in the diabetic rats, meanwhile increased the total antioxidant capacity in the pancreas from diabetic rats."	( Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress-mediated oxidative stress. Chatterjee, S; Dornadula, S; Mohanram, RK; Suganya, N, 2018)	2.64
"Quercetin treatment decreased the levels of intracellular signalling proteins in PKD mouse kidneys, including phosphorylated protein kinase B (also known as AKT) and phosphorylated extracellular signal-regulated kinase (ERK), which are upregulated and promote cyst development in ADPKD."	( Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model. Du, L; Guo, H; Sun, Y; Teng, T; Wang, H; Yang, B; Yin, X; Zhu, Y, 2018)	2.64
"Quercetin pretreatment significantly alleviated LPS-induced cardiac abnormalities in mice."	( Quercetin exerts cardiovascular protective effects in LPS-induced dysfunction in vivo by regulating inflammatory cytokine expression, NF-κB phosphorylation, and caspase activity. Li, C; Meng, X; Shen, F; Wei, X; Yang, J; Yuan, Y, 2018)	2.64
"Quercetin treatment at a dose of 10 mg/kg failed to cause any significant changes in the levels of BDNF mRNA CONCLUSION: Our findings suggest that the neuroprotective effects of quercetin may be at least partly due to its inducing effects on the expression levels of the BDNF mRNA (Fig."	( Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain. Mashayekhi, FJ; Owji, AA; Rahvar, M, 2018)	1.6
"Quercetin or rutin co-treatment with SASP significantly reversed organ weights, preserved sperm integrity, restored plasma hormone levels and increased cholesterol levels, 3β-HSD and 17β-HSD activities in testis."	( Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats. Farombi, EO; Osawe, SO, 2018)	2.64
"In quercetin-treated groups, serum AST, ALT, MDA levels, and tissue MDA concentration were decreased as inversely with increasing quercetin dose."	( Quercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: An experimental research. Alataş, İÖ; Şahin, A; Şahintürk, V; Uylaş, MU, 2018)	2.44
"Quercetin treatment improved the wound healing process in I/R lesions by suppressing MAPK pathway."	( Topical application of quercetin improves wound healing in pressure ulcer lesions. Wang, X; Wang, Z; Yin, G, 2018)	1.51
"Quercetin-3-glucoside treatment also alleviated of endoplasmic reticulum stress in the embryos of diabetic mice (P < .05)."	( Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice. Meng, F; Reece, EA; Tan, C; Zhao, Z, 2018)	1.43
"Quercetin-treated model rats had reduced serum levels of parathyroid hormone (PTH), inorganic phosphate, increased urine protein-to-creatinine ratio, increased urine antioxidants, serum lactate dehydrogenase (LDH), and interleukin (IL)-8 when compared with the untreated model group and the control group."	( Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease. Li, R; Liang, YN; Song, Y; Yang, H, 2018)	2.64
"Quercetin treatment significantly attenuated Ox-LDL-induced VSMC calcification, reduced ALP activity, down-regulated the expression levels of Msx2, BMP2 and Osterix, and up-regulated the expressions of vascular smooth muscle contractile proteins SMA and SM22a."	( [Quercetin attenuates Ox-LDL-induced calcification in vascular smooth muscle cells by regulating ROS-TLR4 signaling pathway]. Chen, Y; Li, C; Liang, Q; Lu, L, 2018)	2.11
"Quercetin treatment significantly augmented SOD, GSH, catalase and 5 HT levels."	( A Natural Phenolic Compound Quercetin Showed the Usefulness by Targeting Inflammatory, Oxidative Stress Markers and Augment 5-HT Levels in One of the Animal Models of Depression in Mice. Akhtar, M; Khan, K; Najmi, AK, 2019)	1.53
"Quercetin treatment at 37°C induced mitochondrial fragmentation and decreased membrane potential (ΔΨ"	( Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat-induced skeletal muscle injury. Chen, Y; Deuster, PA; Dohl, J; Gasier, HG; Yu, T, 2019)	1.56
"Quercetin treatment (0-200 μM) for 24h decreases PA-1 cells viability in a dose-dependent manner."	( Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line. Elayapillai, SP; Jagadeesan, A; Teekaraman, D; Viswanathan, MP, 2019)	2.68
"Quercetin cotreatment enhanced activity as well gene expression in F2 generation."	( Cadmium level in brain correlates with memory impairment in F1 and F2 generation mice: improvement with quercetin. Banerjee, BD; Bhattacharya, SK; Chakraborty, S; Halder, S; Kar, R; Mediratta, PK, 2019)	1.45
"Quercetintreated rats exhibited in liver significantly less steatosis without significant changes in inflammation and fibrosis features (S1A1F2; NAS - 2, fibrosis - 2) compared with rats of the 2nd group."	( [Effect of quercetin on morphological changes in nonalcoholic fatty liver disease in high fructose-fed rats]. Kuznetsov, SL; Nikitin, NS, )	1.24
"Quercetin treatment significantly induced the inhibition of root growth and the reduction of H₂O₂ and O₂"	( RNA-Seq Transcriptome Analysis of Rice Primary Roots Reveals the Role of Flavonoids in Regulating the Rice Primary Root Growth. Wang, L; Xu, M; Xu, Y; Zheng, H; Zong, X; Zou, J, 2019)	1.24
"Quercetin treatment was found to significantly reduce anxiety-like behaviors in mTBI-induced mice."	( Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury. Ghorbanihaghjo, A; Kosari-Nasab, M; Mesgari-Abbasi, M; Salari, AA; Shokouhi, G, 2019)	2.68
"Quercetin pretreatment can protect mice against LPSinduced AKI by inhibiting TLR4/NF-κB signaling pathway."	( [Quercetin alleviates lipopolysaccharide-induced acute kidney injury in mice by suppressing TLR4/NF-κB pathway]. He, J; Qin, W; Tan, J; Zhao, L, 2019)	2.87
"Quercetin treatment also increased renal cortical oxygenation and decreased plasma creatinine levels in obese mice, whereas body weight and cholesterol levels were unaltered."	( Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin. Ahmed, L; Chen, X; Hickson, LJ; Jiang, K; Kim, SR; Kirkland, JL; Lerman, LO; Lohmeier, H; Ogrodnik, M; Tang, H; Tchkonia, T; Zhu, XY, 2019)	1.46
"Quercetin treatment in arthritis groups decreased the elevated levels of cytokines in the arthritis control group."	( Effect of quercetin on E-NTPDase/E-ADA activities and cytokine secretion of complete Freund adjuvant-induced arthritic rats. Abdalla, FH; Adefegha, SA; Becker, LV; Casali, EA; Castilhos, LG; Coelho, APV; da Silveira, KL; da Silveira, LL; Leal, DBR; Manzoni, AG; Martins, NMB; Oliveira, JS; Saccol, RDSP, 2019)	1.64
"Quercetin pretreatment blocked the stress-induced corticosterone release and alleviated the brain oxidative stress with the maternal anxiety measures being slightly attenuated, whereas its effects on the offspring immune cell counts were mostly revealed at birth."	( Quercetin alleviates predator stress-induced anxiety-like and brain oxidative signs in pregnant rats and immune count disturbance in their offspring. Baudin, B; Merzoug, S; Tahraoui, A; Toumi, ML, 2013)	2.55
"Quercetin  was pretreated along with Cd for four weeks to assess its cardioprotective effect against Cd intoxication."	( Quercetin potentially attenuates cadmium induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats. Milton Prabu, S; Muthumani, M; Shagirtha, K, 2013)	2.55
"The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane."	( Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats. Baskaran, R; Lalitha, G; Padma, VV; Shirony, NP, 2012)	1.26
"Quercetin treatment suppressed cell growth by inducing G2 arrest and apoptosis in EGFR-overexpressing HSC-3 and TW206 oral cancer cells."	( Quercetin induces growth arrest through activation of FOXO1 transcription factor in EGFR-overexpressing oral cancer cells. Chan, CY; Chou, IT; Huang, CY; Hung, HC; Lee, MF; Lien, CH, 2013)	2.55
"Quercetin treatment reduces levels of inflammatory cytokines and improves lipid peroxidation and IR in NAFLD rats, and its beneficial effects appear to increase with higher dosage."	( [Effects of quercetin on serum levels of resistin and IL-18 and on insulin resistance in nonalcoholic fatty liver disease rats]. Li, SL; Liang, ZQ; Qin, Q; Tang, L; Zhang, MH; Zhou, DS, 2013)	2.21
"The quercetin treatments were administered for eight weeks after model establishment and control groups received simultaneous gavages of isotonic saline, with continuation of the respective diets."	( [Therapeutic efficacy and mechanisms of quercetin in a rat model of nonalcoholic fatty liver disease]. Li, SL; Liang, ZQ; Qin, Q; Zhang, MH; Zhou, DS, 2013)	1.14
"Quercetin treatment may help to delay the progression of NAFLD, possibly by adjusting the balance of inflammatory cytokines."	( [Therapeutic efficacy and mechanisms of quercetin in a rat model of nonalcoholic fatty liver disease]. Li, SL; Liang, ZQ; Qin, Q; Zhang, MH; Zhou, DS, 2013)	1.38
"Quercetin treatment prevented the cadmium-induced increase in NTPDase, 5-nucleotidase, and ADA activities in Cd/ethanol group when compared to saline/ethanol group."	( Neuroprotective effect of quercetin in ectoenzymes and acetylcholinesterase activities in cerebral cortex synaptosomes of cadmium-exposed rats. Abdalla, FH; Cardoso, AM; Fiorenza, AM; Gonçalves, JF; Gutierres, JM; Mazzanti, CM; Morsch, VM; Pereira, LB; Pimentel, VC; Schetinger, MR; Schmatz, R; Serres, JD; Stefanello, N; Vieira, JM; Zanini, D, 2013)	1.41
"Quercetin treatment significantly reduced hind limb contracture, collagen accumulation and expression of TGF-β in irradiated skin."	( Quercetin inhibits radiation-induced skin fibrosis. Chung, EJ; Citrin, D; Gonzalez, F; Horton, JA; Hudak, K; Krausz, K; Li, F; White, A, 2013)	2.55
"Quercetin treatment reduced oxysterol content (P<0.05) after 7 days of refrigerated storage of fresh meat, but did not affect significantly (P>0.05) the level of lipid-derived volatiles in the headspace of the light-exposed stored cooked meat."	( The effect of quercetin dietary supplementation on meat oxidation processes and texture of fattening lambs. Andrés, S; Bodas, R; Giráldez, FJ; Huerga, L; Mateo, J; Morán, L; Prieto, N; Rotolo, L; Tejido, ML, 2014)	1.48
"Quercetin treatment decreased AAA incidence and inhibited the reactive oxygen species generation, nitrotyrosine formation and lipid peroxidation production in the aortic tissue during AAA development."	( Quercetin reduces oxidative stress and inhibits activation of c‑Jun N‑terminal kinase/activator protein‑1 signaling in an experimental mouse model of abdominal aortic aneurysm. Cheng, X; Jing, H; Li, H; Lu, H; Qiu, F; Shen, Y; Wang, B; Wang, L; Wang, Y; Wu, H; Yang, N, 2014)	2.57
"Quercetin pretreatment evidently alleviated mitochondrial oxidative stress by inhibiting glutathione depletion and aconitase inactivation, ROS over-generation, and lipid peroxidation in cardiac mitochondria of intense exercise mice."	( Myocardial mitochondrial oxidative stress and dysfunction in intense exercise: regulatory effects of quercetin. Chen, S; Chen, X; Gao, C; Li, J; Li, Y; Liu, L; Tang, Y; Yao, P; Yu, H, 2014)	1.34
"Quercetin treatment alone and with CdF2 also caused a significant increase in total Hyp and total collagen in mice liver."	( Effect of quercetin on cadmium fluoride-induced alterations in hydroxyproline/collagen content in mice liver. Siddiqi, NJ; Zargar, S, 2014)	1.53
"Quercetin treatment before CCK application exerted no protection on MMP but increased ATP to a normal level, leading to a continuous decrease in the dehydrogenase activity."	( Beneficial effect of the bioflavonoid quercetin on cholecystokinin-induced mitochondrial dysfunction in isolated rat pancreatic acinar cells. Jonas, L; Krüger, B; Wakileh, M; Weber, H, 2014)	1.39
"Quercetin (0.02%) treatment was administered in the food 3 days prior to 5-FU administration and for the duration of the experiment (ie, days -2 to 14)."	( Dietary quercetin reduces chemotherapy-induced fatigue in mice. Davis, JM; Mahoney, SE; McClellan, JL; Murphy, EA; Pena, MM, 2014)	1.56
"Quercetin pre-treatment at 25 and 50 μm had a cytoprotective effect on cells against TUN-induced toxicity. "	( Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells. Bhakkiyalakshmi, E; Paulmurugan, R; Ramkumar, KM; Suganya, N; Suriyanarayanan, S, 2014)	3.29
"Quercetin treatment did not improve treadmill run-time-to-fatigue, hyperglycemia, or hyperlipidemia in cachectic Apc(Min/+) mice."	( Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice. Carson, JA; Davis, JM; Enos, RT; Murphy, EA; Narsale, AA; Puppa, MJ; Velázquez, KT, 2014)	2.57
"Quercetin (50mg/kg) treatment during restraint stress (21 days) markedly decreased escape latency and increased time spent in target quadrant during Morris water maze task."	( Chronic administration of quercetin prevent spatial learning and memory deficits provoked by chronic stress in rats. Abrari, K; Elahdadi Salmani, M; Goudarzi, I; Lashkarbolouki, T; Mohammadi, HS, 2014)	1.42
"Quercetin treatment downregulated USP10 and promoted T-bet degradation in a proteasome dependent way."	( Deubiquitination and stabilization of T-bet by USP10. Chen, C; Chen, Z; Li, B; Li, D; Pan, L; Shi, G; Wan, H; Wang, L, 2014)	1.12
"Quercetin treatment at various concentrations was examined in combination with Cisplatin, taxol, Pirarubicin and 5-Fu in human epithelial ovarian cancer C13* and SKOV3 cells. "	( Low concentration of quercetin antagonizes the cytotoxic effects of anti-neoplastic drugs in ovarian cancer. Chen, G; Li, N; Ma, D; Sun, C; Weng, D; Xing, H; Zhou, B, 2014)	2.16
"Quercetin treatment resulted in an increased cell arrest in G1 phase of the cell cycle, with pronounced decrease in CDK2, CDK6, cyclin D, cyclin E, and cyclin A proteins, decreased Rb phosphorylation and increased p21 and p27 expression."	( Multitarget effects of quercetin in leukemia. Calgarotto, AK; Filho, PL; Franchi, GC; Maso, V; Nowill, AE; Saad, ST; Vassallo, J, 2014)	1.43
"Quercetin treatment down-regulated the expression of the PI3K and p-Akt."	( Quercetin suppresses HeLa cells by blocking PI3K/Akt pathway. Fang, Y; Wang, SX; Xiang, T, 2014)	2.57
"Quercetin treatment caused a reduction in polyuria (~45%) and glycemia (~35%), abolished the hypertriglyceridemia and had significant effects on renal function including, decreased proteinuria and high plasma levels of uric acid, urea and creatinine, which were accompanied by beneficial effects on the structural changes of the kidney including glomerulosclerosis. "	( Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy. Campagnaro, BP; Gomes, IB; Meyrelles, SS; Pereira, TM; Porto, ML; Santos, MC; Vasquez, EC, 2014)	2.08
"Also quercetin treatment resulted in a marked increase in plasma and testicular testosterone concentrations."	( Alleviative effect of quercetin on rat testis against arsenic: a histological and biochemical study. Hussain, I; Iftikhar, N; Jahan, S; Rukh, G; Ullah, H, 2015)	1.19
"Quercetin treatment attenuated the development of AD-like skin lesions."	( Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. Afrin, R; Arumugam, S; Harima, M; Karuppagounder, V; Miyashita, S; Nakamura, M; Nomoto, M; Pitchaimani, V; Sreedhar, R; Suzuki, H; Suzuki, K; Thandavarayan, RA; Watanabe, K, 2015)	1.38
"Quercetin cotreatment significantly improved the testicular antioxidant status, decreased DNA fragmentation and restored the testicular histology, thus demonstrating the protective effect of quercetin in PCBs-treated rats."	( Quercetin ameliorates polychlorinated biphenyls-induced testicular DNA damage in rats. Adedara, IA; Barbisan, F; Costabeber, IB; da Cruz, IB; da Rocha, MI; Dalberto, M; de Oliveira, CR; Lovato, FL; Marroni, NP; Moreira, KL, 2016)	2.6
"Quercetin treatment inhibited cell growth and led to upregulation of Nrf2 at both the mRNA and protein levels without altering the ubiquitination and extending the half-life of the Nrf2 protein."	( Nrf2 Expression and Apoptosis in Quercetin-treated Malignant Mesothelioma Cells. Lee, DM; Lee, SH; Lee, YJ, 2015)	1.42
"Quercetin treatment dose-dependently decreased the p62 protein expression and increased GFP-LC3B."	( Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Eo, SK; Lee, JH; Moon, JH; Park, SY, 2015)	2.58
"Quercetin pretreatment significantly improved the cardiac function of LPS-challenged mice (P<0.05), and attenuated LPS-induced increment in myocardial iNOS expression and decrement in eNOS level. "	( [Quercetin protects against lipopolysaccharide-induced cardiac injury in mice]. Deng, H; Dong, X; Li, J; Yang, F; Zhang, J, 2015)	2.77
"Quercetin pretreatment significantly reduced the ConA-induced elevations in plasma aminotransferase concentrations and liver necrosis, as well as reducing serum concentrations of the pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interferon-γ, and interleukin-4."	( Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway. Li, X; Liu, HC; Tu, CT; Xu, BL; Yao, QY; Zhang, SC, 2016)	2.6
"quercetin-treated group)."	( Modulation of BV-2 microglia functions by novel quercetin pivaloyl ester. Kuniaková, M; Mrvová, N; Račková, L; Škandík, M, 2015)	1.39
"Quercetin treatment did not significantly alter the pharmacokinetic parameters of atorvastatin like AUC(0-24), AUC(0-α) , T(max), C(max) and T(½) in both single dose and multiple dose studies of Atorvastatin Calcium."	( Quercetin does not alter the oral bioavailability of Atorvastatin in rats. Babu, N; Challa, SR; Devi, R; Geddam, LB; Koritala, R; Ragam, SK; Sattenapalli, S; Venkatesh Reddy Challa, VR, 2015)	2.58
"In quercetin treated group an increase in the mitochondrial DNA copy number and mitochondrial content in both the regions of rat brain was observed."	( Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway. Bal, A; Gill, KD; Priyanka, K; Sharma, DR; Sharma, RK; Sunkaria, A; Verma, D; Wani, WY, 2015)	2.37
"Quercetin treatment significantly prevented tissue deposition of arsenic within the testis."	( Ameliorative effect of quercetin against arsenic-induced sperm DNA damage and daily sperm production in adult male rats. Ain, QU; Iqbal, T; Jahan, S; Munawar, A; Rehman, S; Ullah, H, 2016)	1.47
"Quercetin treatment resulted in restoration of spermatogenesis and reversal of histological damage."	( Therapeutic effects of quercetin against bisphenol A induced testicular damage in male Sprague Dawley rats. Ain, QU; Jahan, S; Ullah, H, 2016)	1.47
"Quercetin treatment decreased the levels of Nos2 expression, protein nitrosylation, and protein nitration, alleviating nitrosative stress."	( Amelioration of intracellular stress and reduction of neural tube defects in embryos of diabetic mice by phytochemical quercetin. Cao, L; Liu, P; Meng, F; Reece, EA; Tan, C; Zhao, Z, 2016)	1.36
"Quercetin treatment increased SUMOylation levels in both SHSY5Y cells and rat cortical neurons in a dose and time-dependent manner, possibly via the direct inactivation of certain SENPs (SUMO-specific isopeptidases)."	( Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose. Bernstock, JD; Hallenbeck, JM; Ko, B; Lee, YJ; Nagaraja, N, 2016)	1.39
"Quercetin pretreatment alleviated the stress-induced behavioural and haematological impairments in dams but failed to attenuate the haematological changes in neonates."	( Effects of quercetin on predator stress-related hematological and behavioral alterations in pregnant rats and their offspring. Merzoug, S; Tahraoui, A; Toumi, ML, 2016)	1.55
"Quercetin treatment induced the myocardial expression of Prx-3 but not Prx-5 both in control and STZ rats."	( Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy. Arkat, S; Singh, S; Sitasawad, SL; Umbarkar, P, 2016)	1.16
"Quercetin pretreatment (20 mg/kg i.p.; 0.5 h before trauma) significantly improved posttraumatic cardiomyocyte apoptosis and cardiac dysfunction."	( Protective Effect of Quercetin on Posttraumatic Cardiac Injury. Bi, Y; Cao, T; Chen, X; Jing, Z; Li, S; Li, X; Wang, Z; Yu, D; Zhou, J; Zhu, L, 2016)	1.47
"Quercetin pretreatment showed protective effects on heart by significantly attenuating the ISO-induced oxidative stress, inflammation, protecting heart architecture, and by downregulation of the expression of calpain."	( Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol-induced acute myocardial injury in rats. Bodduluru, LN; Kasala, ER; Kumar, M; Kumar, V; Lahkar, M, 2017)	1.42
"Quercetin treatment resulted in an upregulation of Nrf2 expression and cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD) levels were restored by quercetin treatment."	( Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway. Fan, Y; Gao, Y; Li, L; Li, X; Mao, L; Tang, C; Wang, H; Wen, G; Zhou, M; Zhou, Y, 2016)	1.47
"Quercetin pre-treatment was observed to suppress the expression of Hsp70 as well the protective function of co-enzyme Q10 at 5 h of heat stress."	( Hsp70 expression induced by Co-Enzyme Q10 protected chicken myocardial cells from damage and apoptosis under in vitro heat stress. Bao, E; Song, E; Tang, S; Wu, D; Xu, J; Yin, B, 2017)	1.18
"Quercetin treatment also reduced the expression levels of glucose‑regulated protein 78, phosphorylated protein kinase‑like ER kinase, phosphorylated c‑Jun N‑terminal kinase and C/EBP homologous protein."	( Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine. Bao, L; Cai, X; Dai, X; Ding, Y; Li, Y; Zhang, Z, 2017)	2.62
"Quercetin treatment alleviated memory dysfunction and rescued neurons from CUS-mediated damage."	( Quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male Swiss albino mice by attenuating insulin resistance and elevating hippocampal GLUT4 levels independent of insulin receptor expression. Mehta, V; Parashar, A; Sharma, A; Singh, TR; Udayabanu, M, 2017)	2.62
"Quercetin treatment significantly lowered oxidative and inflammatory stress and prevented neural damage."	( Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress. Mehta, V; Parashar, A; Udayabanu, M, 2017)	2.62
"Quercetin treatment led to lower epithelial thickness, subepithelial smooth muscle thickness, goblet and mast cell numbers compared to untreated  mice with allergic airway inflammation (p<0.05)."	( Effects of Quercetin Treatment on Epithelium-derived Cytokines and Epithelial Cell Apoptosis in Allergic Airway Inflammation Mice Model. Anal, O; Arikan Ayyildiz, Z; Bagriyanik, A; Caglayan Sozmen, S; Cilaker Micili, S; Isik, S; Karaman, M; Karaman, O; Uzuner, N, 2016)	1.55
"Quercetin treatment suppressed the accumulation of malondialdehyde and increased glutathione peroxidase levels during doxorubicin and cyclophosphamide treatment (P <.05) Conclusions."	( Protective Effect of Quercetin Against Oxidative Stress-induced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue. Dogan, Z; Erdemli, E; Kocahan, S; Taskin, E, 2017)	1.5
"Quercetin pretreatment and following UVA exposure resulted in increased reactive oxygen species production and intracellular glutathione level depletion in human dermal fibroblasts."	( The Phototoxic Potential of the Flavonoids, Taxifolin and Quercetin. Kosina, P; Psotová, M; Rajnochová Svobodová, A; Ryšavá, A; Ulrichová, J; Vostálová, J; Zálešák, B, 2017)	1.42
"Quercetin pre-treatment resulted in increased irinotecan C(max) and area under curve (AUC) with a concomitant decrease in t(max), plasma clearance and volume of distribution (p<0.05)."	( Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein. Awasthi, A; Bansal, T; Jaggi, M; Khar, RK; Talegaonkar, S, 2008)	1.28
"Quercetin treatment also significantly reduced hypoxia-induced secretion of VEGF."	( Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis. Lee, DH; Lee, YJ, 2008)	2.51
"and quercetin treatments for 14 days significantly reduced (p=0.000) the serum uric acid levels of hyperuricemic rats in a time-dependent manner."	( Hypouricemic and antioxidant activities of Allium cepa Lilliaceae and quercetin in normal and hyperuricemic rats. Eshraghian, MR; Haidari, F; Keshavarz, SA; Mahboob, SA; Rashidi, MR; Shahi, MM, 2008)	1.06
"Quercetin treatment reduced circulating levels of HMGB1 in animals with established endotoxemia."	( Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. Kang, R; Lotze, MT; Tang, D; Wang, H; Xiao, W; Xiao, X; Zhang, H, 2009)	2.52
"Quercetin pretreatment strongly suppressed UVA-induced apoptosis in human keratinocyte HaCaT cells, markedly increased protein levels of the transcription factor Nrf2, induced the expression of antioxidative genes, and dramatically reduced the production of reactive oxygen species following UVA irradiation."	( Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Ishii, T; Ishii, Y; Itoh, K; Kawachi, Y; Kimura, S; Ma, D; Warabi, E; Yanagawa, T, 2009)	1.31
"Quercetin co-treatment significantly blocked both PCB77 and PCB126 induction of CYP1A1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin and P-selectin."	( Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs. Arzuaga, X; Caraballo, A; Choi, YJ; Hennig, B; Kluemper, CT; Toborek, M, 2010)	2.52
"Quercetin treatment markedly attenuated the Cd-induced biochemical alterations in serum, urine and renal tissue."	( Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Prabu, SM; Renugadevi, J, 2010)	2.52
"Quercetin treatment also caused a measurable increase in the mRNA expression of human 8-oxoguanine DNA glycosylase (hOGG1) at 0 and 4h after H2O2 treatment (measured using RT-PCR)."	( Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells. Ebeler, SE; Min, K, 2009)	2.52
"Quercetin treatment promoted activation of caspase-3, -8 and -9 in MDA-MB-231 cells."	( Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Chen, DR; Chien, SY; Chung, JG; Kuo, SJ; Lu, HF; Tsou, MF; Wood, WG; Wu, YC; Yang, JS, 2009)	2.52
"No quercetin treatment effect was observed for any of the outcome measures in this study."	( Quercetin's effect on cycling efficiency and substrate utilization. Dumke, CL; McAnulty, LS; McAnulty, SR; Nieman, DC; Quindry, JC; Rigby, MD; Triplett, NT; Utter, AC, 2009)	2.31
"Quercetin treatment enhanced TRAIL-induced activation proteins in the caspase pathway, such as poly (ADP-ribose) polymerase (PARP), caspase-3, and caspase-9."	( Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5. Heo, J; Jung, YH; Kim, YH; Kwon, TK; Lee, YJ, 2010)	2.52
"Quercetin pretreatment significantly (P<0.05) lowered ST-segment elevation and decreased the levels of lipid peroxidation products in plasma and heart in isoproterenol treated cardiotoxic rats."	( Pretreatment with quercetin ameliorates lipids, lipoproteins and marker enzymes of lipid metabolism in isoproterenol treated cardiotoxic male Wistar rats. Prince, PS; Sathya, B, 2010)	1.42
"Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium."	( The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Cao, X; Chan, CC; Liu, M; Shen, D; Tuo, J, 2010)	1.43
"The quercetin-treated K562, SNU1, and SNU-C4 cells showed an enhanced susceptibility to NK-92 cells through induction of NKG2D ligands."	( Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70. Bae, JH; Chang, SH; Chung, JS; Kang, CD; Kim, JY; Kim, MJ; Kim, SH; Lee, EY; Park, SJ; Park, YS; Son, CH, 2010)	2.28
"Quercetin treatment induced no significant changes in the hypertensive responses to angiotensin I and angiotensin II, as well in the hypotensive responses to bradykinin (all p>0.05)."	( Chronic treatment with quercetin does not inhibit angiotensin-converting enzyme in vivo or in vitro. Dias-Junior, CA; Kanashiro, A; Montenegro, MF; Neto-Neves, EM; Spiller, F; Tanus-Santos, JE, 2010)	1.39
"Quercetin treatment for 30min enhanced relaxation of rat aortic ring segments."	( Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels. Constance, C; Inoue, T; Khoo, NK; Parks, DA; Patel, RP; Pozzo-Miller, L; White, CR; Zhou, F, 2010)	1.42
"In quercetin-treated animals, MPO activity was significantly decreased in tissue at 12 and 24 h and in serum at 6, 12 and 24 h after injury, compared with saline controls. "	( Quercetin attenuates inflammatory processes after spinal cord injury in an animal model. Griebel, RW; Juurlink, BH; Schültke, E, 2010)	2.42
"Quercetin-treated groups (10, 20, or 40 mg/kg, p.o.) also showed significant memory impairments compared with the control group in the Y-maze task (P < 0.05)."	( Quercetin impairs learning and memory in normal mice via suppression of hippocampal phosphorylated cyclic AMP response element-binding protein expression. Jung, WY; Kim, DH; Kim, JM; Park, DH; Park, SJ; Ryu, JH, 2010)	2.52
"Quercetin pretreatment increased total GSH levels, but did not increase Trx2."	( After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Abin-Carriquiry, JA; Antúnez, K; Arredondo, F; Blasina, F; Dajas, F; Echeverry, C; Go, YM; Jones, DP; Liang, YL, 2010)	1.37
"Quercetin treatment of K-562 cells was accompanied by cell cycle arrest in G2/M and apoptosis with caspase-3 activation."	( Apoptosis and content of mobile lipid domains in human leukemia K-562 cells induced to differentiate by quercetin or dimethyl sulfoxide. Kuyava, LM; Mikhailenko, VM; Philchenkov, AA; Zavelevich, MP, )	1.07
"Quercetin treatment restored plasma nitrite and nitroso species levels to those found in the sham-vehicle group (P < 0.05)."	( Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension. Castro, MM; Ceron, CS; Dias-Junior, CA; Gomes, VA; Kanashiro, A; Montenegro, MF; Neto-Neves, EM; Tanus-Santos, JE, 2010)	2.52
"Quercetin treatment also markedly suppressed the histological changes such as pancreatic edema, inflammatory cell infiltration, acinar cell necrosis, and the expression of TNF-alpha."	( The natural flavonoid quercetin ameliorates cerulein-induced acute pancreatitis in mice. Carvalho, KM; de Andrade, GM; de Castro Brito, GA; de Melo, TS; Morais, TC; Rao, VS; Santos, FA, 2010)	1.4
"Quercetin-treated, elastase/LPS-exposed mice showed improved elastic recoil and decreased alveolar chord length compared to vehicle-treated controls. "	( Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression. Burgess, JR; Chattoraj, A; Chattoraj, SS; Comstock, AT; Curtis, JL; Faris, AN; Ganesan, S; Hershenson, MB; Martinez, FJ; Sajjan, US; Zick, S, 2010)	3.25
"Quercetin treatment markedly reduced ischemia-induced up-regulation of MMP-9 at 24 and 48 h after ischemic injury. "	( Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats. Jang, JW; Kim, HS; Kim, SH; Kwak, HJ; Lee, JK; Piao, MS, 2011)	3.25
"Quercetin treatment (30mg/kg body weight) over 14 consecutive days markedly increased the striatal dopamine and antioxidant enzyme levels compared with similar measurements in the group treated with 6-OHDA alone."	( Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum. Haleagrahara, N; Kumari, M; Mitra, NK; Siew, CJ, 2011)	1.36
"Quercetin pretreated lymphocytes showed a significant protection against the cytotoxic effects inducted by Dimethoate on the studied parameters."	( Protective effect of quercetin against oxidative stress caused by dimethoate in human peripheral blood lymphocytes. Abdallah, FB; Elfekih, A; Gargouri, B; Khaled, H; Lassoued, S; Mansour, RB, 2011)	1.41
"Quercetin treatment caused significant decreases in lipid peroxide levels in the TAA-treated rats, with some changes in antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)."	( Role of quercetin in preventing thioacetamide-induced liver injury in rats. Bona, S; de David, C; González-Gallego, J; Marroni, NP; Meurer, L; Rodrigues, G; Tuñón, MJ, 2011)	1.52
"Quercetin treatment improved viability of P19 neurons exposed to both types of oxidative injury."	( Neuroprotective effect of quercetin against hydrogen peroxide-induced oxidative injury in P19 neurons. Erhardt, J; Jazvinšćak Jembrek, M; Oršolić, N; Puhović, J; Vuković, L, 2012)	1.4
"Quercetin treatment also attenuated RV-induced airway cholinergic hyperresponsiveness."	( Quercetin inhibits rhinovirus replication in vitro and in vivo. Comstock, AT; Faris, AN; Ganesan, S; Hershenson, MB; Nanua, S; Sajjan, US; Wang, Q, 2012)	2.54
"Quercetin treatment reversed the effects of high glucose in a dose-dependent manner."	( Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model. Chen, P; Chen, W; Shi, Q; Wang, H; Wang, Y; Xu, X, 2012)	2.54
"Quercetin treatment improved whole body insulin sensitivity by increasing GLUT4 expression and decreasing JNK phosphorylation, and TNFα and iNOS expression in skeletal muscle."	( Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes. Anhê, FF; Anhê, GF; Bordin, S; Hirabara, SM; Kinote, A; Lellis-Santos, C; Lima, GA; Machado, UF; Okamoto, MM; Sollon, C; Velloso, LA, 2012)	2.54
"Quercetin treatment can improve memory and learning ability as well as cognitive ability in neonates with WMD, suggesting that quercetin protects against WMD resulting from hypoxia-ischemia."	( [Effects of quercetin on the learning and memory ability of neonatal rats with hypoxic-ischemic brain damage]. Huang, JJ; Liu, X; Qi, DS; Wang, XQ; Yang, LH; Yao, RQ, 2012)	2.2
"Quercetin treatment attenuated oedema in a dose-dependent manner and decreased histological signs of acute inflammation in the treated animals. "	( Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat. Chen, J; Huang, J; Li, S; Sun, W; Tao, Y; Wang, S; Zhu, M, 2012)	2.12
"Quercetin treatment induced the apoptosis of A2780S cells associated with activating caspase-3 and caspase-9."	( Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Gao, X; Gou, M; Guo, G; Huang, M; Huang, N; Men, K; Qian, Z; Wang, B; Wei, X; Wei, Y; Zheng, F; Zheng, Y; Zhou, Y, 2012)	1.34
"Quercetin treatment also attenuated the expression of both TNF-alpha (TNF-α) and interleukin-10 (IL-10) and lowered the serum levels of inflammatory cytokine (P < 0.05)."	( Protective roles of quercetin in acute myocardial ischemia and reperfusion injury in rats. Jin, HB; Li, YR; Song, YL; Yang, YB; Zhang, YC, 2012)	1.42
"Quercetin pretreatment reduced the ROS generation stimulated by either CSE or H(2)O(2) in preadipocyte OFs."	( Cigarette smoke extract-induced adipogenesis in Graves' orbital fibroblasts is inhibited by quercetin via reduction in oxidative stress. Chae, MK; Lee, EJ; Lee, HJ; Lee, SY; Yoon, JS, 2013)	1.33
"Quercetin pretreatment ameliorated these alterations."	( Modulatory role of quercetin against gamma radiation-mediated biochemical and morphological alterations of red blood cells. Bhattacharjee, S; Chakraborty, A; Das, DK; Dey, S; Manna, K; Mukherjee, D; Sinha, M, 2013)	1.44
"Quercetin treatment did not improve oocyte nuclear maturation, but significantly higher blastocyst rates (p < 0.05) of parthenogenetically activated oocytes were achieved when the IVM medium was supplemented with an adequate concentration of quercetin (1 µg/mL)."	( Quercetin improves the in vitro development of porcine oocytes by decreasing reactive oxygen species levels. Jang, G; Kang, JT; Kim, SJ; Koo, OJ; Kwon, DK; Lee, BC; Moon, JH; Park, SJ, 2013)	2.55
"Quercetin pre-treatment (88.7 micromol/kg p.o., 45 min; 14.7 micromol/kg i.v., 5 min) significantly potentiated the hypotensive effect of bradykinin (10 nmol/kg i.v.)."	( Inhibition of angiotesin-converting enzyme by quercetin alters the vascular response to brandykinin and angiotensin I. Cuttle, G; Dovichi, SS; Häckl, LP; Lima-Landman, MT; Nicolau, M, 2002)	1.29
"Quercetin treatment raised blood glucose concentrations in normal and diabetic rats, whereas treatment with coenzyme Q(10) did not."	( Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. Coldiron, AD; Sanders, RA; Watkins, JB, 2002)	1.36
"Quercetin-treated strains showed by 13-20% fewer nodules than untreated controls."	( Preincubation of Mesorhizobium ciceri with flavonoids improves its nodule occupancy. Kamboj, DV; Kukreja, K; Sharma, PK; Upadhyay, KK, 2002)	1.04
"Quercetin treatment significantly increased GSH levels and activities of these enzymes when compared to the I/R group (p<0.05, p<0.01, p<0.05, respectively)."	( Protective effect of quercetin on renal ischemia/reperfusion injury in rats. Erkasap, N; Kahraman, A; Köken, T; Serteser, M, )	1.17
"Quercetin treatment did not induce oxidative damage, but protected mouse thymocytes from glucose oxidase (GO)-mediated apoptosis in a dose-dependent manner."	( The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis. Chung, GH; Jang, YS; Kim, J; Lee, JC; Park, JK, 2003)	1.29
"Quercetin treatment reduced the beta-hexosaminidase release response to concanavalin A."	( Effects of water-soluble cigarette smoke extracts upon the release of beta-hexosaminidase from RBL-2H3 basophilic leukaemia cells in response to substance P, compound 48/80, concanavalin A and antigen stimulation. Fowler, CJ; Sandberg, M; Tiger, G, 2003)	1.04
"Quercetin treatment decreased the glutathione concentration and glutathione reductase activity (40 and 34%, respectively) in the liver significantly and to a similar extent in vitamin E-deprived and -undeprived rats."	( Anti- and prooxidant effects of chronic quercetin administration in rats. Chee, KM; Choi, EJ; Lee, BH, 2003)	1.31
"Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCl observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin II, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats."	( Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil. Duarte, J; Galisteo, M; García-Saura, MF; Jiménez, R; Vargas, F; Villar, IC; Wangensteen, R; Zarzuelo, A, 2004)	1.43
"Quercetin treatment attenuated the functional, histological and immunohistochemical alterations induced by cisplatin."	( Protective effect of quercetin on the evolution of cisplatin-induced acute tubular necrosis. Bianchi, Mde L; Coimbra, TM; Costa, RS; Francescato, HD, 2004)	2.09
"Quercetin and verapamil treatments reduced systolic blood pressure of DOCA-salt rats in approximately 67.6 and 63.3% respectively, producing no effect in control animals."	( Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats. Duarte, J; Galisteo, M; García-Saura, MF; Jiménez, R; Vargas, F; Villar, IC; Zarzuelo, A, 2004)	1.37
"Quercetin treatment, by abolishing the NF-kappaB signal transduction pathway, may block the production of noxious mediators involved in the pathogenesis of portal hypertensive gastropathy."	( Quercetin prevents oxidative stress and NF-kappaB activation in gastric mucosa of portal hypertensive rats. Alonso, M; Collado, PS; Fraga, C; González-Gallego, J; Marroni, C; Marroni, N; Moreira, AJ; Zetller, C, 2004)	2.49
"Quercetin treatment of the SW480 human colon cancer cells was found to result in the decreased expression of three proteins and the increased expression of one protein. "	( The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study. Grider, A; Hargrove, JL; Kolli, K; Mouat, MF; Orlando, R, 2005)	2.12
"Quercetin treatment (30 microM, 1.5 month) increased CH(2)/CH(3) ratio by 2.1 fold."	( Analysis of 1H NMR-detectable mobile lipid domains for assessment of apoptosis induced by inhibitors of DNA synthesis and replication. Mikhailenko, VM; Philchenkov, AA; Zavelevich, MP, 2005)	1.05
"Quercetin treatment reduced systolic blood pressure of GB rats, producing no effect in control animals."	( Effects of chronic quercetin treatment in experimental renovascular hypertension. Bermejo, A; Duarte, J; Galisteo, M; García-Saura, MF; Vargas, F; Villar, IC; Zarzuelo, A, 2005)	1.38
"Quercetin and rutin treatment did not influence the echocardiographical and histo logical parameters in normal animals."	( Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats. Annapurna, A; Chalam, CR; Gopal, GS; Krishna, KM; Kumar, VK; Madan, K; Prakash, GJ, 2005)	1.34
"Quercetin pretreatment significantly reversed the decrease in caspase-1, -6, and -8 activities and the antiapoptotic effect of MG132 on IFN-gamma-treated LECs."	( Upregulation of heat shock protein expression by proteasome inhibition: an antiapoptotic mechanism in the lens. Awasthi, N; Wagner, BJ, 2005)	1.05
"In quercetin-treated mice, delayed neuronal damage was significantly decreased compared with vehicle-treated mice."	( Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Cho, JY; Jang, YH; Kim, AR; Kim, IS; Lee, SR, 2006)	1.17
"Quercetin treatment obviously relieved the degree of hepatic fibrosis, significantly reduced the expression of immediate early gene, tissue inhibitor of metalloproteinase 1 (TIMP 1), types I and III collagen compared to the control."	( [Inhibition of quercetin on liver fibrosis due to Schistosoma japonicum infection and on the expression of immediate early gene and metalloproteinase 1 inhibitor in liver tissue of mice]. Han, CR; He, SS; Xu, B, 2006)	1.41
"In quercetin-treated PC-3 cells, an increase in Bax protein expression and a decrease in Bcl-x(L) protein and Bcl-2 protein were observed."	( Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3. Arunakaran, J; Arunkumar, A; Dharmarajan, A; Ilangovan, R; Kanagaraj, P; Vijayababu, MR, 2006)	2.29
"Quercetin pretreatment administered prior to the induction of differentiation also exerted stimulatory effects on the osteogenic differentiation of hADSC."	( Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Bae, YC; Jung, JS; Kim, YJ; Suh, KT, 2006)	2.5
"Quercetin treatment of cells caused a significant time- and dose-dependent increase in the caspase-3 activity."	( Induction of cell apoptosis in 3T3-L1 pre-adipocytes by flavonoids is associated with their antioxidant activity. Hsu, CL; Yen, GC, 2006)	1.06
"Quercetin treatment of hepatoma cells resulted in changes of cell cycle progression."	( Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells. Chang, YF; Chi, CW; Wang, JJ, 2006)	1.31
"Quercetin treatment reduced blood glucose level in diabetic rats."	( Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas. Achike, FI; Machha, A; Mustafa, AM; Mustafa, MR, 2007)	2.5
"Quercetin treatment and HSF1 silencing increased the pro-apoptotic effect of doxorubicin."	( Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing's sarcoma cell lines. Bisaro, B; Carta, F; Crescenzio, N; di Montezemolo, LC; Doria, A; Foglia, L; Giribaldi, G; Mandili, G; Timeus, F; Turrini, F; Zanini, C, 2007)	1.31
"Quercetin treatment reduced the inflammation-induced over-expression of VCAM-1 and ICAM-1 (protein and transcript) in HUVECs."	( Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells. Connor, C; Hughes, DA; Kroon, PA; Lodi, F; Needs, PW; Suri, S; Taylor, MA; Tribolo, S; Wilson, VG, 2008)	1.38
"Quercetin treatment also led to a translocation of the C."	( Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Chovolou, Y; Kampkötter, A; Proksch, P; Ruhl, S; Timpel, C; Wätjen, W; Zurawski, RF, 2008)	1.3
"All quercetin treatment groups produced increases in the GSH:GSSG ratio and decreases in mixed disulfide levels in hepatic tissue."	( Influence of dietary quercetin on glutathione redox status in mice. Meyers, KJ; Mitchell, AE; Rudolf, JL, 2008)	1.15
"Quercetin pretreatment increased AUC(0-infinity) of pioglitazone after oral administration by 75% and AUC(0-infinity) after intravenous administration by 25% suggesting decreased metabolism, which could be due to inhibition of CYP3A by quercetin."	( Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibition. Bansod, KU; Dixit, PV; Kumar, V; Umathe, SN; Wanjari, MM, 2008)	2.51
"Quercetin treatment did not show any notable effect on intracellular levels of glutathione in either used concentration of quercetin."	( The protective effect of quercetin against oxidative stress in the human RPE in vitro. Kampik, A; Kook, D; Neubauer, AS; Priglinger, SG; Welge-Lüssen, UC; Wolf, AH; Yu, AL, 2008)	1.37
"Quercetin treatment (100 microM) also caused a decrease in Ser136 phosphorylation of Bad, which is a downstream target of Akt."	( Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Lee, DH; Lee, YJ; Szczepanski, M, 2008)	1.42
"Quercetin treatment produced differential regulation of Cyp1A1 and Cyp1B1 mRNA expression in a time- and dose-dependent manner."	( Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin. Bhat, HK; Chhabra, J; Mense, SM, 2008)	1.27
"Some quercetin-treated groups showed a significant decrease in the average weight of day-20 foetuses compared with the corresponding control weight."	( Teratogenic potential of quercetin in the rat. Willhite, CC, 1982)	1.02
"Quercetin-treated tumor cells were not induced to show aggregation of HSP70 in the nuclei and nucleolus in response to heat shock, resulting in apoptosis."	( Induction of apoptosis by quercetin: involvement of heat shock protein. Fukata, H; Kariya, Y; Teshigawara, K; Uchida, A; Wei, YQ; Zhao, X, 1994)	1.31
"Quercetin treatments also caused a small but significant reduction (17-18%) in DLP relative gland weights (gland wt/body wt) in T + E2-treated animals."	( In vitro and in vivo inhibition of nuclear type II estrogen binding sites in the dorsolateral prostate of noble rats. Ho, SM; Viccione, T; Yu, M, 1993)	1.01
"Quercetin treatment significantly decreased FI630nm and increased the ratio FI520nm/FI630nm when compared with DMBA-induced lesions."	( Inhibitory effect of dietary flavonol quercetin on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Balasubramanian, S; Govindasamy, S, 1996)	1.29
"Quercetin-treated cells did not show any differentiation but showed 68% apoptosis as compared to 7% in control."	( Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells. Deora, AB; Miranda, MB; Rao, SG, )	0.85
"In quercetin-treated animals, the decrease in nitric oxide concentration was slower, such that substantial amounts (60(20) nmol/l) accumulated during reperfusion."	( Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia-reperfusion injury: an experimental study. Brovkovych, V; Huk, I; Malinski, T; Nanobash Vili, J; Neumayer, C; Partyka, L; Patton, S; Weigel, G, 1998)	1.18
"Quercetin treatment mollified ischaemia-reperfusion injury to skeletal muscle by scavenging destructive superoxide and enhancing the cytoprotective nitric oxide concentration."	( Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia-reperfusion injury: an experimental study. Brovkovych, V; Huk, I; Malinski, T; Nanobash Vili, J; Neumayer, C; Partyka, L; Patton, S; Weigel, G, 1998)	2.11
"Quercetin treated animals did not show increased oxidation of LDL (and VLDL in rabbits) and cholesterol levels were not decreased."	( Probucol selectively increases oxidation of atherogenic lipoproteins in cholesterol-fed mice and in Watanabe heritable hyperlipidemic rabbits. Lauridsen, ST; Mortensen, A, 1999)	1.02
"Quercetin treatment downregulated both PMA- and TNF-alpha-induced surface expression, as well as the ICAM-1 mRNA levels, in ECV cells in a dose-dependent (10-50 microM) manner."	( Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. Kobuchi, H; Nguyen, HG; Packer, L; Roy, S; Sen, CK, 1999)	2.47
"Quercetin-treated RBL-2H3 cells in which expression of G(alphai2) and G(alphai3) is enhanced more than 7-fold respond to the G(i) stimulant compound 48/80 with the activation of PLD, a transient activation of phospholipase C, and enhanced membrane GTPase activity."	( Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins. Beaven, MA; Chahdi, A; Fraundorfer, PF, 2000)	1.03
"Quercetin treatment alone slightly enhanced binding of AP-1 complexes to this site."	( Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer. Pickwell, GV; Quattrochi, LC; Shih, H, 2000)	1.03
"With quercetin treatment, these proteins were significantly reduced."	( Quercetin inhibits c-fos, heat shock protein, and glial fibrillary acidic protein expression in injured astrocytes. Wu, BY; Yu, AC, 2000)	2.2
"Quercetin treatment of diabetic rats reversed only the diabetic effects on brain oxidized glutathione concentration and on hepatic glutathione peroxidase activity."	( Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. Rauscher, FM; Sanders, RA; Watkins, JB, 2001)	1.42
"Quercetin treatment resulted in the accumulation of cells specifically at G2/M phase of the cell cycle."	( Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Choi, JA; Kang, CM; Kim, JY; Kim, TW; Kwon, HJ; Lee, JY; Lee, SJ; Lee, YS; Yoo, YD, 2001)	1.26
"Quercetin pretreatment significantly inhibited NO production in an LPS-stimulated RAW 264.7 murine macrophage cell line."	( The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. Chakravortty, D; Koide, N; Mori, I; Mu, MM; Sugiyama, T; Takahashi, K; Yokochi, T; Yoshida, T, 2001)	1.34
"Quercetin treatment, however, resulted in a moderate increase in Cip1/p21 with no change in Kip1/p27 and a decrease in CDK4 and cyclin D1."	( Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. Agarwal, C; Agarwal, R; Bhatia, N, 2001)	1.26
"Quercetin-treated female medaka had a significantly increased number of atretic ovarian follicles, but no significant differences in the extent of apoptosis in intestine, liver or kidney."	( Increased cellular apoptosis after chronic aqueous exposure to nonylphenol and quercetin in adult medaka (Oryzias latipes). Hwang, GS; Janz, DM; Kiparissis, Y; Metcalfe, CD; Niimi, AJ; Weber, LP, 2002)	1.26
"Quercetin treatment suppressed the JNK activity and ameliorated apoptosis induced by H2O2."	( Inhibition of c-Jun N-terminal kinase ameliorates apoptosis induced by hydrogen peroxide in the kidney tubule epithelial cells (NRK-52E). Araki, I; Matsushita, K; Takeda, M; Wang, L, 2002)	1.04
"Quercetin treatment could decrease JNK activity and ameliorate H2O2-induced apoptosis."	( Inhibition of c-Jun N-terminal kinase ameliorates apoptosis induced by hydrogen peroxide in the kidney tubule epithelial cells (NRK-52E). Araki, I; Matsushita, K; Takeda, M; Wang, L, 2002)	1.04
"Quercetin treatment, which enhanced rather than inhibited motility, depressed heat and lactate production by 50-60%."	( Motility, heat, and lactate production in ejaculated bovine sperm. Hammerstedt, RH; Racker, E; Volonté, C, 1988)	1
"Treatment with quercetin dihydrate promoted the killing activity of T cells on MDA-MB-231 and NCI-H460 cancer cells."	( Quercetin inhibiting the PD-1/PD-L1 interaction for immune-enhancing cancer chemopreventive agent. Diao, A; Jing, L; Li, Y; Lin, J; Liu, Z; Tao, L; Yang, Y; Zhao, Q, 2021)	2.4
"Treatment with quercetin led to an increased in"	( Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles. Chen, YA; Fan, C; Gu, EM; Luo, SB; Xu, RA; Zhou, SC, 2022)	1.46
"Pretreatment with quercetin was effective at attenuating histopathologic changes in hepatic and renal tissues by regulating the immunoexpression of caspase-3 and Bcl-2 to return them to more normal values."	( Gibberellic acid-induced hepatorenal dysfunction and oxidative stress: Mitigation by quercetin through modulation of antioxidant, anti-inflammatory, and antiapoptotic activities. Abdelhadi, AA; Alsanie, WF; Elbadawy, M; Gaber, A; Metwally, MMM; Mohamed, WA; Shukry, M; Soliman, MM, 2022)	1.27
"Treatment with quercetin in vitro increased PON2 protein levels and prevented oxidative stress from different types of stimuli."	( Airway epithelial Paraoxonase-2 in obese asthma. Cooney, R; Holguin, F; Liu, C; Monzon, A; Saal, M; Sharma, S; Vladar, EK; Winnica, DE; Ye, S, 2022)	1.06
"Pretreatment with quercetin, TNF-α antagonist, PP1, U0126, or Bay 11-7082 reduced TNF-α-induced p65 phosphorylation and translocation and p65-Luc activity in a dose- and time-dependent manner."	( Quercetin exerts anti-inflammatory effects Cheng, LC; Chu, MY; Hsieh, HL; Huang, TH; Tsai, MM; Yeh, TS; Yu, MC, 2022)	2.49
"Treatment with quercetin reversed lysosomal dysfunction and promoted autophagosome-lysosome fusion, which restored defective autophagic flux and provoked autophagy."	( Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux. Guan, L; Guo, L; Li, P; Liu, H; Lyu, K; Peng, L; Qiao, Y; Wang, H; Wang, Z; Yan, X; Zhai, Y; Zhang, H; Zhao, J; Zhou, W, 2022)	2.5
"Co-treatment with quercetin and/or curcumin decreased the warfarin-induced CYP3A protein expression."	( Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity Burkina, V; Rasmussen, MK; Zamaratskaia, G, 2022)	1.41
"Co-treatment of quercetin 30 mg/kg/day through oral gavage for 60 days along with rotenone significantly reversed all these adverse effects, suggesting that quercetin could reduce neuroinflammation, and improve memory, and cognitive function."	( Neuroprotective effect of quercetin against rotenone-induced neuroinflammation and alterations in mice behavior. Biswas, P; Hasan, W; Jain, J; Jat, D; Yadav, RS, 2022)	1.36
"Treatment with quercetin abrogated HFrD-induced oxidative stress, along with attenuation of NLRP3 activation in the liver."	( Convergence of Fructose-Induced NLRP3 Activation with Oxidative Stress and ER Stress Leading to Hepatic Steatosis. Ahmad, I; Ahmad, S; Gulzar, F; Guru, B; Kumar, P; Sharma, A; Singh, S; Tamrakar, AK, 2023)	1.25
"Treatment of quercetin efficiently decreased the senescence markers in senescent BMSCs models."	( Bone-targeted delivery of senolytics to eliminate senescent cells increases bone formation in senile osteoporosis. Gao, X; Huang, H; Li, M; Liang, C; Liao, L; Ma, S; Tan, L; Tang, Q; Tian, W; Xing, X; Xu, X; Yang, J; Zou, J, 2023)	1.26
"Treatment with quercetin, a purified product from traditional Chinese medicine (TCM) that shows effective treatment of COVID-19 patients, can significantly inhibit SARS-CoV-2 N protein-induced AKI in diabetic mice with or without underlying DKD."	( Treatment with quercetin inhibits SARS-CoV-2 N protein-induced acute kidney injury by blocking Smad3-dependent G1 cell-cycle arrest. Chen, J; Huang, XR; Lan, HY; Liang, L; Wang, W; Wang, X; Wei, B; Wu, W; Yu, X, 2023)	1.6
"The treatment with quercetin inhibited cell proliferation of colon cancer cells in a dose-dependent manner."	( A Comprehensive Study on the Anti-cancer Effects of Quercetin and Its Epigenetic Modifications in Arresting Progression of Colon Cancer Cell Proliferation. Banerjee, A; Bhatiya, M; Duttaroy, AK; Jothimani, G; Pathak, S, 2023)	1.48
"Treatment with quercetin-incorporated collagen matrix showed a significant decrease in thymidine phosphorylase level compared with the untreated and collagen-treated groups."	( Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand-foot syndrome induced by capecitabine in rats. Abdin, AA; Hedya, SE; Kotb, HM; Mashaly, ME, 2023)	1.5
"A pretreatment with quercetin (1-1000 nM) did not effectively protect Neuroscreen-1 cells from death induced by serum starvation."	( Flavonoid quercetin and its glucuronide and sulfate conjugates bind to 67-kDa laminin receptor and prevent neuronal cell death induced by serum starvation. Aguilar, J; Gopalakrishna, R; Hou, L; Lee, E; Li, A; Mack, WJ; Oh, A, 2023)	1.63
"Treatment with quercetin, naringenin, or rutin increased the expression and interaction of the microRNAs' hsa-miR-34a-5p, hsa-miR-30b-5p, hsa-let-7a-5p, and hsa-miR-26a-1-3p."	( Evaluation of the Possible Pathways Involved in the Protective Effects of Quercetin, Naringenin, and Rutin at the Gene, Protein and miRNA Levels Using In-Silico Multidimensional Data Analysis. Alkahtani, HM; Altwaijry, N; Wani, TA; Zargar, S, 2023)	1.48
"Treatment with quercetin dose- and time-dependently inhibited the proliferation of HSC-T6 cells and significantly increased the total cell apoptosis rate ("	( [Quercetin induces hepatic stellate cell apoptosis by inhibiting the PI3K/Akt signaling pathway Gao, X; Jin, R; Ma, Y; Yan, Y; Zhang, C; Zhao, X, 2023)	2.17
"Treatment with quercetin suppressed UV-induced matrix metalloproteinase-1 (MMP-1) and cyclooxygenase-2 (COX-2) expression and prevented UV-mediated collagen degradation in human skin tissues."	( Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. Byun, S; Hong, S; Lee, JS; Lim, TG; Shin, EJ, 2019)	2.3
"Pre-treatment with quercetin (25 and 50 mg/kg, p.o.), piperine (2.5 mg/kg, p.o.) alone, quercetin (25 mg/kg, p.o.) in combination with piperine (2.5 mg/kg), and ropinirole (0.5 mg/kg, i.p.) was administered for 28 days 1 h prior to rotenone and iron supplement administration."	( Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement-Induced Parkinson's Disease in Experimental Rats. Raj, K; Sharma, S; Singh, S, 2020)	1.18
"Treatment with quercetin increased the adiponectin level and expression of adipoR1 and nesfatin-1 and decreased both the expression of aromatase and the oestradiol level."	( The phytoestrogen, quercetin, in serum, uterus and ovary as a potential treatment for dehydroepiandrosterone-induced polycystic ovary syndrome in the rat. Jafari Khorchani, M; Neisy, A; Zal, F, 2020)	1.23
"Treatment with quercetin 50 mg/kg attenuated the freezing, anxiety-like and depressive-like behaviors."	( Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation. Anggreini, P; Ardianto, C; Khotib, J; Rahmadi, M, 2019)	2.3
"Pretreatment with quercetin did not influence the responses to phenylephrine and tamsulosin, in neither WKY nor SHR. "	( Haemodynamic effects of the flavonoid quercetin in rats revisited. Bast, A; Janssen, BJ; Opperhuizen, A; van Essen, H; Vrolijk, MF, 2020)	1.16
"Co-treatment with quercetin and low dose of radiation significantly reduced the expressions of all five proteins of γ-secretase complex in HT-29 and DLD-1 cells."	( Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway. Cai, Y; He, GQ; Jin, J; Li, SH; Li, Y; Wang, J; Wang, Z; Zhu, SX, 2020)	2.32
"Rats treated with quercetin showed no changes in the protein levels of citrate synthase or cytochrome C oxidase IV or those of sirtuin 1, peroxisome proliferator-activated receptor gamma coactivator-1α or phosphorylated AMPK."	( Effect of Quercetin Treatment on Mitochondrial Biogenesis and Exercise-Induced AMP-Activated Protein Kinase Activation in Rat Skeletal Muscle. Honda, A; Koshinaka, K; Masuda, H; Sato, A, 2020)	1.28
"Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells. "	( Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-β/AKT/mTOR signaling pathway. Chen, A; Huang, G; Liu, G; Luo, L; Qin, C; Wei, P; Xiao, Y; Zhang, T; Zhou, L, 2020)	1.19
"Treatment with quercetin showed a decrease in the inflammatory status and an increase in the oxidative status of adipose cells, thereby exhibiting its anti-inflammatory and anti-oxidative properties."	( Effect of the anti-retroviral drug, rilpivirine, on human subcutaneous adipose cells and its nutritional management using quercetin. Adem, A; Behl, S; Hussain, A; Singh, J, 2020)	1.11
"Co-treatment with quercetin reduces pyruvate concentrations compared to TNFα-only treated controls."	( Anti-Inflammatory Effects of Quercetin on High-Glucose and Pro-Inflammatory Cytokine Challenged Vascular Endothelial Cell Metabolism. Kroon, PA; Le Gall, G; Needs, PW; Ozyel, B, 2021)	1.24
"Treatment with quercetin and/or cisplatin was performed after 2 months of MNU induced testicular carcinogenesis."	( Efficacy of Quercetin-Sensitized Cisplatin against N-Nitroso-NMethylurea Induced Testicular Carcinogenesis in Wistar Rats. El-Diasty, HH; El-Ghaweet, HA; El-Sayyad, H; Refaat, S, 2021)	1.34
"Treatment of quercetin with PA-1 cells also downregulates the tight junctional molecules such as Claudin-4 and Claudin-11 while upregulates the expression of occludin."	( Quercetin attenuates metastatic ability of human metastatic ovarian cancer cells via modulating multiple signaling molecules involved in cell survival, proliferation, migration and adhesion. Arunakaran, J; Dhanaraj, T; Mohan, M, 2021)	2.42
"Treatment with quercetin improved the PCOS related disturbances in estrous cycle, lipid profile, serum levels of testosterone, estradiol and progesterone, and IR."	( Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis. Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L, 2021)	1.26
"Treatment with quercetin markedly reduced ear thickness and swelling."	( Inhibitory Effect of Quercetin on Propionibacterium acnes-induced Skin Inflammation. Jeon, YD; Jin, JS; Kang, SH; Lim, HJ; Song, YJ, 2021)	1.28
"Treatment with quercetin and vitamin E resulted in 34% decrease of apoptogenic cytochrome c release."	( Quercetin and vitamin E attenuate diabetes-induced testicular anomaly in Wistar rats via the mitochondrial-mediated apoptotic pathway. Ojo, OO; Olorunsogo, OO, 2021)	2.4
"Pre-treatment with quercetin and rottlerin, PKCδ signaling inhibitors, significantly suppressed the PMA-induced elevation of glucagon secretion."	( Protein kinase C-δ signaling regulates glucagon secretion from pancreatic islets. Fukui, H; Kobayashi, M; Mizuguchi, H; Sato, Y; Tamaki, M; Tokashiki, N; Yamamoto, K; Yamauchi, A, 2017)	0.77
"Treatment with quercetin was used 15 days after the induction of preneoplastic lesions."	( Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis. Baltiérrez-Hoyos, R; Carrasco-Torres, G; Martínez-Guerra, AA; Monroy-Ramírez, HC; Romero-Tlalolini, MLÁ; Sánchez-Chino, X; Vásquez-Garzón, VR; Villa-Treviño, S, 2017)	2.24
"Treatment with quercetin significantly attenuated cell migration and invasion in HOS and MG63 cells compared with treatment with control medium."	( Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells. Bai, B; Fan, P; Hong, W; Lan, H; Qian, D; Zhu, J, 2017)	2.24
"Pretreatment with quercetin significantly restored LPS-suppressed bone mineralization and the mRNA and protein expression levels of osteoblast-specific genes such as Osterix (OSX), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN) in a dose-dependent manner. "	( Protective Effects of Pretreatment with Quercetin Against Lipopolysaccharide-Induced Apoptosis and the Inhibition of Osteoblast Differentiation via the MAPK and Wnt/β-Catenin Pathways in MC3T3-E1 Cells. Guo, C; Jang, K; Liu, YZ; Yang, RJ; Zhou, XL, 2017)	1.06
"72-h treatment with quercetin induced a dose-dependent decrease of all OCR parameters (basal respiration, proton leak, ATP turnover, maximal respiration, reserve capacity) as well as of ECAR."	( Quercetin exerts an inhibitory effect on cellular bioenergetics of the B164A5 murine melanoma cell line. Ancușa, S; Danciu, C; Dehelean, C; Duicu, O; Muntean, D; Pavel, I; Sturza, A, 2018)	2.24
"Treatment with quercetin resulted in the alleviation of cadmium-induced behavioral and neurochemical alterations."	( Involvement of PKA/DARPP-32/PP1α and β- arrestin/Akt/GSK-3β Signaling in Cadmium-Induced DA-D2 Receptor-Mediated Motor Dysfunctions: Protective Role of Quercetin. Dhuriya, YK; Gupta, R; Khanna, VK; Pandey, A; Pant, AB; Sharma, T; Shukla, RK; Siddiqi, MI; Singh, MP; Srivastava, P, 2018)	1.02
"Treatment with quercetin and green tea induced conversion of LC3-I to LC3-II as well as activation of autophagy proteins, suggesting that quercetin and green tea initiate the autophagic progression."	( Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells. Calgarotto, AK; Filho, PL; Junior, GCF; Maso, V; Nowill, AE; Saad, STO; Vassallo, J, 2018)	1.13
"Treatment with quercetin in the pristane-induced LN mice model was nephroprotective, decreasing proteinuria levels and significantly lowering tissue expression of IL-6, TNF-α, TGF-β1, Bax and TBARS."	( Protective effects of quercetin treatment in a pristane-induced mouse model of lupus nephritis. Bona, SR; Bonomini, F; Dos Santos, M; Favero, G; Marroni, NP; Montanari, CC; Poletti, PT; Rezzani, R; Stacchiotti, A; Veronese, FV, 2018)	1.14
"Treatment with quercetin-3-glucoside (suspended in water) significantly decreased neural tube defect rate and apoptosis in the embryos of diabetic mice, compared with those in the water-treated diabetic group (3.1% vs. "	( Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice. Meng, F; Reece, EA; Tan, C; Zhao, Z, 2018)	1.06
"Treatment with quercetin significantly inhibited ROS generation, inflammation and MMP‑2 protein expression in the rat model CPR."	( Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. Jiang, XM; Liu, XL; Lou, X; Wang, D; Yang, C; Zhang, N, 2018)	2.26
"Treatment with quercetin‑3‑methyl ether alone markedly suppressed the levels of tri‑methyl histone H3 (Lys27), but had no effect on the expression of enhancer of zeste homolog 2."	( Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways. Cao, L; Li, C; Li, J; Liang, T; Lin, B; Yang, Y; Ye, Z; Zeng, J; Zhou, K, 2018)	2.26
"Pretreatment with quercetin, rottlerin, SP600125, or Bay 11-7082 attenuated TNF-α-induced NF-κB (p65) phosphorylation, translocation and RelA/p65-Luc activity."	( Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-α-activated retinal pigment epithelial cells. Cheng, CY; Cheng, SC; Huang, TH; Huang, WC; Pang, JS; Wu, YH, 2019)	1.13
"The treatment of quercetin supplement to aspirin rescued the declined survival rate and weight of pups caused by L-NAME-induced pre-eclampsia."	( Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME. Ma, Y; Shi, X; Song, L; Yang, S; Zhao, N, 2019)	1.11
"Oral treatments of quercetin and αOR at this dosage exhibited no anti-allergic effect, and IQC showed less effect than EMIQ."	( Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice. Kanemaru, M; Makino, T; Mizukami, H; Okuyama, S; Shimizu, R; Tanaka, H, 2013)	0.94
"Co-treatment with quercetin (2.5, 5, and 10 mmol/L) dose-dependently decreased HG-induced caspase-3 activation and apoptosis."	( Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition. Liang, XC; Qu, L; Shi, Y; Sun, Q; Wu, QL; Zhang, H, 2013)	2.16
"Treatment with quercetin prevented the increase in AChE activity when compared to Cd/ethanol group."	( Neuroprotective effect of quercetin in ectoenzymes and acetylcholinesterase activities in cerebral cortex synaptosomes of cadmium-exposed rats. Abdalla, FH; Cardoso, AM; Fiorenza, AM; Gonçalves, JF; Gutierres, JM; Mazzanti, CM; Morsch, VM; Pereira, LB; Pimentel, VC; Schetinger, MR; Schmatz, R; Serres, JD; Stefanello, N; Vieira, JM; Zanini, D, 2013)	1.03
"Treatment with quercetin-containing drugs, particularly, water-soluble corvitin and tableted quertin exerted favourable effect on cardiac hemodynamics, normalized systolic and diastolic function in cardiac remodeling, induced by sustained beta-adrenergic stimulation."	( [Experimental therapy of cardiac remodeling with quercetin-containing drugs]. Dosenko, VE; Kuzmenko, MA; Moybenko, AA; Pavlyuchenko, VB; Tumanovskaya, LV, )	0.73
"Treatment with quercetin rather than cisplatin resulted in a marked elevation of p16 expression in HepG2 cells."	( Synergistic growth-suppressive effects of quercetin and cisplatin on HepG2 human hepatocellular carcinoma cells. Jiao, HJ; Zhao, J; Zhao, JL, 2014)	1.01
"Pre-treatment with quercetin ameliorated ROS and calcium release as well as NF-κB induction and expression."	( Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-κB and COX-2. Krishnaswamy, R; Padma, VV; Ramyaa, P, 2014)	2.16
"Pretreatment with quercetin decreased cell viability only at the highest concentration of 37 microg/mL 2, 24, and 48 h after the treatment. "	( Inhibitive effect on phagocytosis of Candida albicans induced by pretreatment with quercetin via actin cytoskeleton interference. Bo, P; Cui, S; Qian, J, 2013)	0.95
"Pretreatment with quercetin induced an anti-inflammatory effect against Candida albicans infection in macrophages."	( Inhibitive effect on phagocytosis of Candida albicans induced by pretreatment with quercetin via actin cytoskeleton interference. Bo, P; Cui, S; Qian, J, 2013)	0.95
"Treatment with quercetin decreased the number of caspase-3 and TUNEL positive cells."	( The protective effect of quercetin on IMA levels and apoptosis in experimental ovarian ischemia-reperfusion injury. Coşar, E; Demirtaş, S; Gencer, M; Güngör, AN; Hacıvelioğlu, SÖ; Hancı, V; Karaca, T; Korkmaz, F; Turkon, H; Uysal, A, 2014)	1.05
"Co-treatment with quercetin prevented reduction in T-SH, GSH, and GR activities and the rise of GST activity."	( Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na(+),K(+)-ATPase activities. Abdalla, FH; Baldissarelli, J; Barbisan, F; Cardoso, AM; Carvalho, FB; da Cruz, IB; de Oliveira, JS; Dressler, VL; Gonçalves Nunes, MA; Gonçalves, JF; Mazzanti, CM; Morsch, VM; Pereira, LB; Rosa, MM; Rubin, MA; Schetinger, MR; Schmatz, R, 2014)	2.17
"The treatment with quercetin 25 and 50 mg/kg prevented this increase in the ATP and ADP hydrolysis, while the treatment with quercetin 5, 25, and 50 mg/kg prevented the increase in the ADA activity."	( Protective effect of quercetin in ecto-enzymes, cholinesterases, and myeloperoxidase activities in the lymphocytes of rats exposed to cadmium. Abdalla, FH; Baldissarelli, J; Cardoso, AM; da Costa, P; de Oliveira, LS; Gonçalves, JF; Lhamas, CL; Martins, CC; Mazzanti, CM; Morsch, VM; Pereira, LB; Pimentel, VC; Schetinger, MR; Schmatz, R; Zanini, D, 2014)	1.04
"Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST)."	( Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A. Chen, LJ; Chen, XC; Tang, MH; Wan, Y; Wang, YS; Wei, YQ, 2014)	1.03
"Treatment with quercetin reduced AKT phosphorylation, and oxidative/nitrosative stress, inflammation and lipid metabolism-related genes displayed a tendency to normalize in both in vivo and in vitro models."	( Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease. Benet, M; Fernández, A; García-Mediavilla, MV; González-Gallego, J; Jover, R; Martínez-Ferreras, Á; Martínez-Flórez, S; Olcoz, JL; Pisonero-Vaquero, S; Sánchez-Campos, S, 2015)	2.2
"Treatment with quercetin aglycone and PAC DP-9, which exhibited the strongest activity, induced apoptosis, led to caspase-3 activation and PARP deactivation, and increased sensitivity to cisplatin."	( The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Chen, E; Chichester, CO; Han, A; Moore, RG; Singh, AP; Singh, RK; Vorsa, N; Wang, Y, 2015)	1.03
"Pre‑treatment with quercetin (5 or 10 mg/kg orally (p.o.); once daily) induced a dose‑dependent reduction in I/R‑induced hippocampal neuron cell loss, with 10 mg/kg/day being the lowest dose that achieved maximal neuroprotection."	( Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway. Chao, H; Lei, X; Li, F; Li, S; Li, Z; Lv, J; Wei, H; Xue, R; Zhang, Z, 2015)	1.03
"Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice."	( Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice. Barreto, M; Elorza, AA; Jensen, E; Quintanilla, RA; Ruiz, LM; Ruiz, PA; Salazar, C; Tiznado, W, 2015)	2.2
"Treatment with quercetin, quercetin 3-O-glucoside, and quercetin 7-O-glucoside differentially suppressed epidermal growth factor-induced migration activity of human pancreatic cancer cells."	( Quercetin 3-O-glucoside suppresses epidermal growth factor-induced migration by inhibiting EGFR signaling in pancreatic cancer cells. Han, SI; Kim, JH; Lee, J; Yun, JH, 2015)	2.2
"Treatment with quercetin alleviated the decline in renal function, and the progression of renal fibrosis and inhibited mTORC1/p70S6K activation in the diabetic renal cortex."	( Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy. Ji, XJ; Liu, YQ; Lu, Q; Yao, XQ; Yin, XX; Zhang, F; Zhou, YX, 2015)	2.2
"Pretreatment with quercetin or hydroxytyrosol attenuated the phosphorylation of MAPKAPK-2 and cleaved caspase-3 in X/XO-exposed cells (p < 0.01, vs."	( Quercetin and hydroxytyrosol attenuates xanthine/xanthine oxidase-induced toxicity in H9c2 cardiomyocytes by regulation of oxidative stress and stress-sensitive signaling pathways. Bali, EB; Karasu, C; Ozbek, N, 2015)	2.18
"The treatment with quercetin did not modify body weight gain but uterine (296.7 ± 5.11 versus 263.0 ± 8.60 mg) and ovary weights (49.5 ± 1.93 versus 37.8 ± 3.43 mg) were found to be decreased significantly (p <0.05) as compared with the PCOS control group. "	( Phosphatidylinositide 3-kinase inhibition: A new potential target for the treatment of polycystic ovarian syndrome. Patel, SS; Shah, KN, 2016)	0.76
"Co-treatment with quercetin (all doses) also exhibited enhanced acquisition and retention memory compared to control."	( Quercetin Modulates the Effects of Chromium Exposure on Learning, Memory and Antioxidant Enzyme Activity in F1 Generation Mice. Banerjee, BD; Bhattacharya, SK; Halder, S; Kar, R; Mediratta, PK; Mehta, AK, 2016)	2.2
"Treatment of quercetin-3-O-glucoside suppressed the migratory activity induced by TGF-β and VEGF-A even at relatively low dosages in CFPAC-1, but not in bFGF-activated SNU-213 cells."	( Quercetin-3-O-glucoside suppresses pancreatic cancer cell migration induced by tumor-deteriorated growth factors in vitro. Kim, JH; Kim, SJ; Lee, J, 2016)	2.23
"Treatment with quercetin caused DNA damage in HepG2, Hep3B2.1-7, and TFK-1 cell lines."	( New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin. Abrantes, AM; Botelho, MF; Brito, AF; Casalta-Lopes, JE; Gonçalves, AC; Laranjo, M; Mamede, AC; Ribeiro, M; Sarmento-Ribeiro, AB; Tralhão, JG, 2016)	1.01
"Treatment of quercetin with CP (7.5 mg/kg) prevents the CP-induced nephrotoxicity along with enhance the anticancer activity confirmed by the reduction of aberrant crypt foci number."	( Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats. Hu, GR; Li, QC; Liang, Y; Tian, Y, )	0.71
"Treatment with quercetin at 15μM had a similar effect as the RQC combination in the inhibition of BC cell proliferation, apoptosis, and migration."	( Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade. Castillo-Pichardo, L; Dharmawardhane, S; Gerena, Y; Rivera Rivera, A, 2016)	1.06
"Treatment with quercetin did not significantly alter HIF-1α levels, but did reduce AaPO2 as well as lung tissue NF-κB activity, VEGFA gene and protein levels, Akt activity, and angiogenesis."	( Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Chen, Y; Li, X; Liu, A; Shang, G; Wang, L; Zhang, C; Zhang, H; Zhao, Z, 2016)	2.22
"Pretreatment with quercetin (20 μM; 24 h before trauma plasma addition) significantly attenuated trauma-induced viability decreases, TNF-α increases, ROS overproduction and [Ca(2+)]i overload in H9c2 cells."	( Protective Effect of Quercetin on Posttraumatic Cardiac Injury. Bi, Y; Cao, T; Chen, X; Jing, Z; Li, S; Li, X; Wang, Z; Yu, D; Zhou, J; Zhu, L, 2016)	1.08
"Pretreatment with quercetin (3, 10, 30 μmol/L) dose-dependently inhibited excessive histamine release from paclitaxel-stimulated RBL-2H3 cells in vitro, and quercetin administration significantly suppressed the high plasma histamine levels in paclitaxel-treated rats. "	( Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1. Gao, W; Hu, XY; Huang, F; Wang, ZJ; Zan, Y, 2016)	2.21
"Pretreatment with quercetin and simvastatin treatment in the hyperlipidemic groups significantly (P<0.05) increased AChE activity compared with the hyperlipidemic group."	( Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats. Adefegha, SA; Braun, JBS; Castilhos, LG; Coelho, APV; de Andrade, CM; Dornelles, GL; Leal, DBR; Oliveira, JS; Rubin, MA; Ruchel, JB; Signor, C; Trelles, KB, 2017)	1.04
"Treatment with quercetin nanoparticle effectively inhibited the liver cancer cell proliferation, cell migration and colony formation, thus suppressing liver cancer progression."	( Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells. Han, XW; Li, YH; Li, ZM; Lu, HB; Ren, JZ; Ren, KW; Wu, G, 2017)	2.24
"Treatment with quercetin in patients receiving doxorubicin and cyclophosphamide results in therapeutic restoration of homeostatic expression of the antioxidant parameters, reducing oxidative damage to the liver and kidney."	( Protective Effect of Quercetin Against Oxidative Stress-induced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue. Dogan, Z; Erdemli, E; Kocahan, S; Taskin, E, 2017)	1.11
"Treatment with quercetin dose-dependently upregulated the expression of HO-1 mRNA in the bone marrow cells."	( The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats. Bzowska, M; Cierniak, A; Jozkowicz, A; Krzysciak, W; Papiez, MA; Piskula, M; Taha, HM, 2008)	0.94
"Pretreatment with quercetin (20 and 40 mg/kg, i.p.) significantly reversed immobilized stress-induced anxiety and analgesia and reduced locomotor activity."	( Quercetin protects against acute immobilization stress-induced behaviors and biochemical alterations in mice. Goyal, R; Kumar, A, 2008)	2.11
"Upon treatment with quercetin, the protein level of survivin was strongly suppressed in U87-MG, U251, and A172 but not in U373 glioma cells."	( Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells. Habel, A; Rami, A; Reuss, DE; Siegelin, MD; von Deimling, A, 2009)	2.11
"Treatment with quercetin can induce p53 target genes such as PUMA and p21."	( Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. Chung, HY; Jung, YS; Lee, SH; Lee, SJ; Park, BJ, 2009)	0.69
"Pretreatment with quercetin alone and alpha-tocopherol alone showed significant effect in all the biochemical parameters in myocardial infarcted rats."	( Combined effects of quercetin and alpha-tocopherol on lipids and glycoprotein components in isoproterenol induced myocardial infarcted Wistar rats. Prince, PS; Punithavathi, VR, 2009)	1
"Treatment of quercetin (5 mg/kg i.p."	( Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons. Han, DD; Yang, Z; Yao, Y; Zhang, T, 2010)	2.16
"Treatment with Quercetin reduced infectious particle production at nontoxic concentrations."	( The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Arumugaswami, V; Dasgupta, A; Fontanes, V; French, SW; Gonzalez, O; Loo, J; Loo, R; Raychaudhuri, S; Sun, R, 2009)	0.97
"Pretreatment with quercetin resulted in the reduction of arsenite-induced expression of COX-2 and production of PGE(2)."	( Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells. Hwang, MK; Lee, DE; Lee, HJ; Lee, KM; Lee, KW, 2010)	1
"Pretreatment with quercetin (10 micromol/L; 30 minutes) prior to H(2)O(2) prevented the loss of ZO-1 and occludin."	( Protective effect of quercetin on hydrogen peroxide-induced tight junction disruption. Chuenkitiyanon, S; Jianmongkol, S; Pengsuparp, T, 2010)	1
"Treatment with quercetin promoted lymphocyte proliferation and regulated Th1/Th2 cytokine imbalance."	( Dietary quercetin combining intratumoral doxorubicin injection synergistically induces rejection of established breast cancer in mice. Du, G; Han, G; Ji, L; Lin, H; Lu, L; Wang, M; Wu, X; Yang, Y; Yu, L; Zhang, S, 2010)	1.13
"Treatment with quercetin (5-20 mg/kg, p.o., twice daily, 30 days) in streptozotocin-induced diabetic rats prevented the changes in blood glucose, body weight, and performance in Morris water and elevated plus maze tasks."	( Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats. Bansod, K; Bhutada, C; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Tawari, S, 2010)	1.01
"Pretreatment with quercetin or thalidomide significantly attenuated the severity of cerulein-induced acute pancreatitis as evidenced by effective reductions in the pancreatic wet weight/body weight ratio, biochemical indices, proinflammatory cytokines, myeloperoxidase activity, malondialdehyde formation, and an increase in antiinflammatory cytokine IL-10."	( The natural flavonoid quercetin ameliorates cerulein-induced acute pancreatitis in mice. Carvalho, KM; de Andrade, GM; de Castro Brito, GA; de Melo, TS; Morais, TC; Rao, VS; Santos, FA, 2010)	1
"Pretreatment with quercetin offered neuroprotection against 6-OHDA-induced PC12 cell death."	( Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish. Cheang, LC; Lee, SM; Wang, MW; Zhang, ZJ, 2011)	2.14
"Pre-treatment with quercetin significantly reduced the frequency of mitomycin C (MMC) induced MN as well as CA, but no clear correlation between the dose and effect could be observed."	( Role of quercetin on mitomycin C induced genotoxicity: analysis of micronucleus and chromosome aberrations in vivo. Giri, A; Giri, S; Mazumdar, M, 2011)	1.12
"Co-treatment with quercetin partially prevented all the renal effects of cisplatin, whereas it did not impair its anti-tumour activity. "	( Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity. Lopez-Hernandez, FJ; Lopez-Novoa, JM; Morales, AI; Perez-Barriocanal, F; Sanchez-Gonzalez, PD, 2011)	2.15
"Pretreatment with quercetin, rutin or okra extract prevented the reduction in NMDA receptor expression."	( Neuroprotective effects of quercetin, rutin and okra (Abelmoschus esculentus Linn.) in dexamethasone-treated mice. Chantiratikul, P; Govitrapong, P; Kongbuntad, W; Pakdeenarong, N; Ruksee, N; Tongjaroenbuangam, W, 2011)	0.99
"Pretreatment with quercetin (70 mg/kg/day/6 weeks) and its coadministration with acrylonitrile prevented acrylonitrile-induced alterations in hepatic lipid peroxides and enzymatic antioxidants as well as serum aminotransferases and bilirubin."	( Hepatoprotective activity of quercetin against acrylonitrile-induced hepatotoxicity in rats. Abd-Ellah, MF; Abo-Salem, OM; Ghonaim, MM, )	0.75
"Treatment with quercetin improved these parameters except blood glucose."	( Quercetin ameliorates diabetic nephropathy by reducing the expressions of transforming growth factor-β1 and connective tissue growth factor in streptozotocin-induced diabetic rats. Lai, PB; Yang, LY; Zhang, L, 2012)	2.16
"Cotreatment of quercetin along with lindane significantly decreased the lindane induced alteration in histology, serum hepatic and renal markers and MDA and also improved the cellular antioxidant status."	( Quercetin attenuates lindane induced oxidative stress in Wistar rats. Baskaran, R; Padma, VV; Poornima, P; Roopesh, RS, 2012)	2.16
"Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB activation, suggest that the effects of quercetin are partially mediated by NF-κB signaling."	( Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model. Chen, P; Chen, W; Shi, Q; Wang, H; Wang, Y; Xu, X, 2012)	2.16
"The treatment of quercetin and allopurinol regulated renal urate transport-related proteins to reduce hyperuricemia, and lipid metabolism-related genes to alleviate kidney lipid accumulation in STZ-treated rats."	( Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. Kong, LD; Pan, Y; Wang, C; Wang, FM; Zhang, QY, 2012)	2.15
"Mice treated with quercetin exhibited a 32.7% reduction in aortic size compared with vehicle-treated controls."	( Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice. Jing, H; Li, H; Liu, X; Lu, H; Qiu, F; Wang, B; Wang, G; Wang, L; Wu, H; Xiong, L; Xu, Y, 2012)	2.15
"Treatment with quercetin either before or after LPS preserved the vascular function, as blood pressure, heart rate, vascular responsiveness were restored to near normal values, particularly when quercetin was given as a preventive regimen."	( Preventive and therapeutic effects of quercetin on lipopolysaccharide-induced oxidative stress and vascular dysfunction in mice. Donpunha, W; Kukongviriyapan, U; Kukongviriyapan, V; Pannangpetch, P; Sompamit, K, 2012)	0.99
"Treatment with quercetin reduces oxidation and inflammation and also prevents liver fibrosis, through induction of HSC apoptosis and activation of MMPs."	( Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance. Alcántar-Díaz, BE; Armendariz-Borunda, J; Bueno-Topete, M; Hernández-Ortega, LD; Ruiz-Corro, LA; Salazar-Montes, AM; Sandoval-Rodriguez, A, 2012)	2.17
"Co-treatment with quercetin (60 mg/kg bw) and BPA (low dose and high dose) alleviates the changes in body weight, as well as absolute and relative organ weights of mice."	( Testing the efficacy of quercetin in mitigating bisphenol A toxicity in liver and kidney of mice. Sangai, NP; Trivedi, MH; Verma, RJ, 2014)	1.03
"Treatment with quercetin partially reversed these changes."	( Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A. Angel, KA; Comstock, AT; Ganesan, S; Mancuso, P; Martinez, FJ; Sajjan, US; Unger, BL, 2013)	0.73
"Pre-treatment with quercetin for 3weeks suppressed TDI-induced nasal allergy-like symptoms and elevation of H1R mRNA in the nasal mucosa of TDI-sensitized rats."	( Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells. Baba, Y; Fukui, H; Hattori, M; Kitamura, Y; Kobayashi, M; Mizuguchi, H; Nakano, T; Ono, S; Sasaki, Y; Takeda, N; Zhang, Q, 2013)	2.15
"Treatment with quercetin resulted in a significant decrease in prostaglandin E2 and cyclooxygenase-2 levels as well as inducible nitric oxide synthase-mediated nitric oxide production induced by lipopolysaccharide."	( Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression. Byun, EB; Byun, EH; Choi, HG; Sin, SJ; Song, DS; Sung, NY; Yang, MS, 2013)	2.17
"Treatment of quercetin showed potent inhibitory effects on the DNA synthesis of cultured HASMC in the presence of TNF-alpha."	( Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Cho, GO; Gal, SW; Jung, SY; Kim, CH; Kwon, TK; Lee, YC; Madamanchi, NR; Moon, SK, 2003)	2.11
"Pretreatment with quercetin significantly enhanced cell survival (LDH release, 5.4 +/- 2.7% for UW and 8.4 +/- 4.2% for EC) in a concentration dependent manner."	( Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions. Ahlenstiel, T; Burkhardt, G; Köhler, H; Kuhlmann, MK, 2003)	0.64
"Pretreatment by quercetin suppressed the arginase activity in the liver (p < 0.05) and plasma levels of urea (p < 0.01)."	( Role of quercetin on hepatic urea production in acute renal failure. Cvetković, T; Nikolić, J; Sokolović, D, 2003)	1.09
"Treatment with quercetin during 3 weeks improved liver histology and reduced collagen content, iNOS expression, and lipid peroxidation."	( Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. González-Gallego, J; Llesuy, S; Marroni, CA; Marroni, N; Pavanato, A; Sánchez-Campos, S; Tuñón, MJ, 2003)	1.05
"Pretreatment (quercetin 25, 50 and 75 mg/kg body weight for 15 d+co-treatment of ethanol 18%+quercetin for 15 d and ethanol 18% for the 15 d) increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) in comparison to the ethanol group."	( Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Benedi, J; Iglesias, I; Molina, MF; Sanchez-Reus, I, 2003)	2.11
"Pretreatment with quercetin significantly alleviated this increase."	( Effect of quercetin on daunorubicin-induced heart mitochondria changes in rats. Chavková, Z; Dubayová, K; Guzy, J; Kusnír, J; Mareková, M; Mirossay, L; Mojzis, J; Mojzisová, G, 2003)	1.04
"Treatment with quercetin significantly attenuated renal dysfunction and oxidative stress in diabetic rats."	( Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Anjaneyulu, M; Chopra, K, 2004)	2.11
"Pretreatment with quercetin dose-dependently (25-100 mg/kg p.o.) reduced the catalepsy score in haloperidol-treated animals."	( Quercetin, a bioflavonoid, reverses haloperidol-induced catalepsy. Kulkarni, SK; Naidu, PS, 2004)	2.09
"Treatment with Quercetin enhanced cytotoxicity of Topotecan as 1.4-fold in MCF-7 and 1.3-fold in MDA-MB-231 cell line."	( The effect of quercetin on topotecan cytotoxicity in MCF-7 and MDA-MB 231 human breast cancer cells. Akbas, SH; Ozben, T; Timur, M, 2005)	1.03
"Pretreatment with quercetin (10microM, 20min) increased ACh-induced relaxation and decreased PE-induced contraction in diabetic, but did not affect euglycemic rat aortic ring responses."	( Effect of quercetin on altered vascular reactivity in aortas isolated from streptozotocin-induced diabetic rats. Achike, FI; Ajay, M; Mustafa, AM; Mustafa, MR, 2006)	1.06
"Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells."	( Quercetin blocks airway epithelial cell chemokine expression. Andrade, JE; Burgess, JR; Hershenson, MB; Lukacs, NW; Nanua, S; Sajjan, US; Zick, SM, 2006)	2.1
"Mice treated with quercetin showed attenuated brain MMP-9 activity."	( Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Cho, JY; Jang, YH; Kim, AR; Kim, IS; Lee, SR, 2006)	0.98
"Treatment with quercetin attenuated these alterations."	( Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys. Antunes, LM; Behling, EB; Bianchi, Mde L; Costa, RS; Francescato, HD; Sendão, MC, )	0.74
"Treatment with quercetin significantly improved arterial blood pressure and peripheral vascular resistance."	( Protective effects of quercetin against phenylhydrazine-induced vascular dysfunction and oxidative stress in rats. Kukongviriyapan, U; Kukongviriyapan, V; Luangaram, S; Pakdeechote, P; Pannangpetch, P, 2007)	0.99
"Treatment with quercetin and catechin could eliminate reactive oxygen species (ROS) to reduce oxidative stress stimulated by S100B in THP-1 cells."	( Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs. Huang, SM; Wu, CH; Yen, GC, 2006)	0.67
"Treatment with quercetin resulted in a significant decrease in Na+ and Ca2+ and aldose reductase levels and an increase in K+ and protein levels in galactosemic cataractous lenses."	( Defensive role of quercetin against imbalances of calcium, sodium, and potassium in galactosemic cataract. Kumar, VV; Raju, TN; Ramana, BV; Reddy, PU, 2007)	1.01
"Treatment with quercetin and kaempferol prevented the production of peroxides, superoxide anion and nitric oxide induced by CM."	( Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells. Almar, M; Crespo, I; García-Mediavilla, MV; González, P; González-Gallego, J; Sánchez-Campos, S; Tuñón, MJ, 2008)	0.69
"Oral treatment with quercetin protected ABD2F1/Jena mice significantly against intraperitoneal encephalomyocarditis, Col, SK, MM, Mengo M,L and MengoM virus infections, but not against intracerebral challenge with MengoM virus. "	( Mechanism of antiviral action of quercetin against cardiovirus infection in mice. Pusztai, R; Veckenstedt, A, 1981)	0.87
"Treatment with quercetin of K562, Molt-4, Raji, and MCAS tumor cell lines resulted in morphological changes, including propidium iodide-stained condensed nuclei (intact or fragmented), condensation of nuclear chromatin, and nuclear fragmentation."	( Induction of apoptosis by quercetin: involvement of heat shock protein. Fukata, H; Kariya, Y; Teshigawara, K; Uchida, A; Wei, YQ; Zhao, X, 1994)	0.93
"Treatment with quercetin caused a dose-dependent increase in the yield of AOM-induced tumors in the colon from 0.06 +/- 0.04 adenocarcinoma/rat to 0.64 +/- 0.12 and 1.14 +/- 0.17 for the low and high dose groups, respectively."	( Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats. Barnes, LH; Eto, I; Grubbs, CJ; Juliana, M; Kelloff, GJ; Li, H; Lubet, RA; Olson, GR; Pereira, MA; Steele, VE; Whitaker, LM, 1996)	0.89
"Pretreatment with quercetin protected mesangial cells from hydrogen peroxide (H2O2)-induced apoptosis."	( Unexpected protection of glomerular mesangial cells from oxidant-triggered apoptosis by bioflavonoid quercetin. Kitamura, M; Yokoo, T, 1997)	0.84
"Pretreatment with quercetin or curcumin resulted in preservation of histological integrity, with a decrease in tubular damage and interstitial inflammation. "	( Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents. Shoskes, DA, 1998)	0.94
"Treatment by quercetin (5 mg/kg i.v.) of intact and ischemia-reperfusion groups did not significantly change the signal amplitude in the cerebellum, but did double it in the cortex (to 76% of control) for the ischemia-reperfusion group (P < 0.05)."	( Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion. Berthet, F; Girard, P; Henry, Y; Pinard, E; Potier, P; Sercombe, R; Seylaz, J; Shutenko, Z, 1999)	0.95
"Pretreatment with quercetin provided protection from structural and functional cell damage in a concentration-dependent manner (10-100 microM)."	( Inhibition of oxidant-induced lipid peroxidation in cultured renal tubular epithelial cells (LLC-PK1) by quercetin. Burkhardt, G; Horsch, E; Köhler, H; Kuhlmann, MK; Wagner, M, 1998)	0.84
"Pretreatment with quercetin (200 mg x kg(-1)per os) 2 h before LPS injection diminished the shock-induced increases in brain MDA, and NO(x)levels while elevating the reduced brain phospholipids' and serum SH groups' content."	( Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain. Abd El-Gawad, HM; Khalifa, AE, 2001)	2.08
"Post-treatment with quercetin partially inhibited NO production."	( The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. Chakravortty, D; Koide, N; Mori, I; Mu, MM; Sugiyama, T; Takahashi, K; Yokochi, T; Yoshida, T, 2001)	0.93
"Treatment with quercetin alone resulted in an apparent decrease of hsp70-positive cells and an increase of subG1 cells in JCA-1 and LNcap cells. "	( Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells. Deguchi, N; Hirata, R; Iida, M; Nakanoma, T; Ueno, M, 2001)	1.05
"Treatment with quercetin inhibited the binding of HSF to the HSE in whole-cell extracts activated in vivo by heat shock and in cytoplasmic extracts activated in vitro by elevated temperature or by urea."	( Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Aoike, A; Hirayoshi, K; Hosokawa, N; Kawai, K; Kudo, H; Nagata, K; Takechi, H, 1992)	0.62
"Pretreatment with quercetin improved coronary stenosis, removing the second phase (15-60 min) of capacity vessel dilatation reaction (blood deposition)."	( [Role of leukotrienes in shock of immune origin]. Sagach, VF, 1986)	0.59

Toxicity

Quercetin and myricetin, both of which produce superoxide on autoxidation, appeared to be more toxic than kaempferol. Tamarixetin quinone prefers to pass reactivity to the antioxidant network, i.e. rather than adduction to CK.

Excerpt	Reference	Relevance
" At interim evaluations at 6 and 15 months, treatment-related toxic lesions were not observed, but at 2 years toxic and neoplastic lesions were seen in the kidney of male rats, including increased severity of chronic nephropathy, hyperplasia, and neoplasia of the renal tubular epithelium."	( Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Dunnick, JK; Hailey, JR, 1992)	0.55
" In addition, as assessed by trypan blue exclusion, quercetin and myricetin, both of which produce superoxide on autoxidation, appeared to be more toxic than kaempferol."	( The toxicity of flavonoids to guinea pig enterocytes. Canada, AT; Nguyen, TD; Watkins, WD, 1989)	0.53
"Bracken fern (Pteridium aquilinum) causes acute and chronic toxicity in animals and is associated with a high incidence of stomach and esophageal tumors in humans in countries where it is consumed as food, yet the toxic constituent(s) has not been unequivocally identified."	( Genotoxicity studies of quercetin and shikimate in vivo in the bone marrow of mice and gastric mucosal cells of rats. Jones, RS; Ngomuo, AJ, 1996)	0.6
" In in vitro experiments, it was demonstrated that estradiol protects cells against the toxic effects of beta-amyloid, the major component of plaques in brains of AD patients."	( Phytoestrogen kaempferol (3,4',5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity. Hertel, C; Roth, A; Schaffner, W, 1999)	0.3
" Morphological observation by phase contrast microscopy revealed that both crocetin and quercetin caused intense damage only on the malignant (RD) cells, whereas mild toxic effect was seen with cisplatin also on normal (Vero) cells."	( In vitro studies on the selective cytotoxic effect of crocetin and quercetin. Gunasekaran, P; Jagadeeswaran, R; Ramamurty, N; Sakthisekaran, D; Thirunavukkarasu, C, 2000)	0.77
"Amyloid beta protein (Abeta) elicits a toxic effect on neurons in vitro and in vivo."	( The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. Chen, CF; Chi, CW; Lin, YL; Shiao, YJ; Wang, CN, 2001)	0.31
" It is primarily considered as a neurotoxin but its other toxic manifestations are also well documented."	( Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo. Bhattacharya, R; Lakshmana Rao, PV, 2001)	0.31
"Cadmium chloride at concentrations of 10-50mM and acetaldehyde (AA) at 1-5mM showed synergistic toxic effects on V79 cells in vitro."	( Synergistic effect of cadmium chloride and acetaldehyde on cytotoxicity and its prevention by quercetin and glycyrrhizin. Chen, WK; Hu, CC; Lee, YJ; Liao, PH; Yu, WC, 2001)	0.53
" With the exception of 5-O-PN, all the other naringenins showed only weak toxic effects at concentrations below 50 micromol/l."	( Toxicity and cell cycle effects of synthetic 8-prenylnaringenin and derivatives in human cells. Gutzeit, HO; Henker, Y; Metz, P; Schwab, P; Tokalov, SV, 2004)	0.32
" Safety was assessed through concomitant medications, adverse events, laboratory evaluations, and physical examinations."	( A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. Farez, C; Khodabandehlou, T; Le Devehat, C; LeFante, C; Richard, JL; Rosenbloom, RA; Valensi, P, )	0.13
" Eleven patients in the QR-333 group reported 23 adverse events (all mild or moderate); 4 in the placebo group reported 5 events (all moderate)."	( A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. Farez, C; Khodabandehlou, T; Le Devehat, C; LeFante, C; Richard, JL; Rosenbloom, RA; Valensi, P, )	0.13
" These data indicate that heat shock protects cells from the toxic effect of MPP(+) and paraquat."	( Heat shock proteins protect both MPP(+) and paraquat neurotoxicity. Donaire, V; Fuentes, JM; García, L; González-Polo, RA; Morán, JM; Niso, M; Soler, G, 2005)	0.33
" For these agents, normal dietary intake, doses used in clinical trials, efficacious doses in rodents, and where available, toxic doses are compared."	( Putative cancer chemopreventive agents of dietary origin-how safe are they? Gescher, AJ; Steward, WP; Verschoyle, RD, 2007)	0.34
"Diesel exhaust particles (DEPs) are particulate matter from diesel exhaust that contain many toxic compounds, such as polyaromatic hydrocarbons (PAHs)."	( Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles. Aizawa, K; Inakuma, T; Izawa, H; Kohara, M; Sagai, M; Suganuma, H; Taya, K; Watanabe, G, 2008)	0.66
" We detected a time-dependent action of quercetin and distinguished an early protective effect from a late toxic one."	( Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells. Kääräinen, TM; Männistö, PT; Ossola, B; Raasmaja, A, 2008)	0.87
" On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1)."	( Polyphenol cytotoxicity induced by the bacterial toxin pyocyanin: role of NQO1. Muller, M, 2009)	0.35
"Q proved to be toxic and did not exert complete protection against As, and only S was able to protect cells from As-induced oxidative death, which started after 4h with caspase activation and phosphatidylserine exteriorization on the outer cellular membrane."	( Cytoprotective effects of silymarin on epithelial cells against arsenic-induced apoptosis in contrast with quercetin cytotoxicity. Bongiovanni, GA; Eynard, AR; Soria, EA, 2010)	0.57
" Based on the above findings, the no observed adverse effect level (NOAEL) was estimated to be 1% in both sexes (542."	( Fifty-two week chronic toxicity of enzymatically decomposed rutin in Wistar rats. Hayashi, M; Kasahara, H; Kobayashi, S; Kuroda, J; Mitsumori, K; Muto, S; Nagasawa, T; Okuhara, Y; Onozato, T; Tamura, T, )	0.13
" It is obvious that hawthorn, particularly flavonoids constituents with antioxidative activity, reduced the oxidative stress and genotoxicity induced by toxic compounds."	( Protective effect of hawthorn extract against genotoxicity induced by methyl methanesulfonate in human lymphocytes. Azadbakht, M; Hosseinimehr, SJ; Mahmodzadeh, A; Mohammadifar, S; Tanha, M, 2011)	0.37
"Cadmium is a toxic heavy metal that is widely distributed in the environment."	( Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice. Bu, T; Mi, Y; Zeng, W; Zhang, C, 2011)	0.69
" In conclusion, TCDD caused an adverse effect on rat's liver."	( Effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity in rats. Ciftci, O; Ozdemir, I; Vardi, N, 2013)	0.78
" In H2O2 plus quercetin co-treated groups, both 75 and 100 μM quercetin attenuated toxic effect of H2O2 by 15%."	( Quercetin both partially attenuates hydrogen peroxide-induced toxicity and decreases viability of rat glial cells. Durmaz, R; Kabadere, S; Oztopcu-Vatan, P; Uyar, R, 2011)	2.17
" These results suggest that LTC exerts its toxic effect by increasing lipid peroxidation, altering the antioxidant enzyme activities and DNA damage."	( Caffeic acid and quercetin protect erythrocytes against the oxidative stress and the genotoxic effects of lambda-cyhalothrin in vitro. Abdallah, FB; Fakhfakh, F; Fetoui, H; Keskes, L, 2012)	0.72
" In contrast, Q and CH significantly prevented toxic effects of TCDD via increased GSH, CAT, GPx and SOD levels but decreased formation of TBARS."	( Ameliorating effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo- p-dioxin-induced nephrotoxicity in rats. Beytur, A; Ciftci, O; Oguz, F; Ozdemir, I; Vardi, N, 2012)	0.69
"To observe the toxicity of hyperoside in rat embryo-fetal development, in order to provide preference for safe use of drugs during gestation period."	( [Study on toxicity of hyperoside in rat embryo-fetal development]. Ai, G; Huang, Z; Liu, Z; Wang, D, 2012)	0.38
" The study revealed that there were no significant treatment related adverse effects in rats exposed to Longevinex for 28 days and considered safe at the given dose where compared to plain Resveratrol."	( Sub-acute toxicity profile of a modified resveratrol supplement. Sali, VK; Sangeetha, MK; Thanka, J; Vallabi, DE; Vasanthi, HR, 2013)	0.39
"The aim of this study was to investigate the toxic impacts of titanium dioxide nanoparticles (TiO₂-NPs) on rat kidneys and the possible prophylactic role of either quercetin or idebenone."	( Potential impact of quercetin and idebenone against immuno- inflammatory and oxidative renal damage induced in rats by titanium dioxide nanoparticles toxicity. Abdel Baky, NA; Al-Rasheed, NM; Faddah, LM; Mohamed, AM; Mohammad, RA, 2013)	0.91
" These toxic effects were also regulated by high-dose quercetin."	( Effect of quercetin against dichlorvos induced nephrotoxicity in rats. Hou, Y; Li, S; Qi, L; Sun, C; Wang, H; Xu, W; Zeng, Y; Zhao, X, 2014)	1.05
" The adverse effect of Fe2O3 NPs is not so significant at lower doses but at higher doses Fe2O3 NPs causes significant damage to cells."	( Iron oxide nanoparticles mediated cytotoxicity via PI3K/AKT pathway: role of quercetin. Sarkar, A; Sil, PC, 2014)	0.63
" Taken together, potent MDR-modulating activity along with intracellular conversion into the natural flavonoid quercetin warrants development of the quercetin-amino acid conjugates as safe MDR modulators."	( Water-soluble and cleavable quercetin-amino acid conjugates as safe modulators for P-glycoprotein-based multidrug resistance. Chong, Y; Choo, H; Kim, MK, 2014)	0.91
"There is an urgent need to make cisplatin (cDDP) more effective and less toxic in the treatment of ovarian cancer for its systemic side effects and high resistance rate."	( Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling. Chen, G; Gao, Q; Gong, C; Liao, J; Liu, Y; Ma, D; Sun, C; Wei, X; Yang, Z; Zhang, T; Zhou, X, 2015)	1.86
" In conclusion, our present data suggests that HNE is highly toxic to serum-starved ARPE-19 cells but quercetin is able to reverse these adverse effects even when administered after an oxidative insult."	( Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells. Honkakoski, P; Hytti, M; Kaarniranta, K; Kauppinen, A; Piippo, N; Salminen, A, 2015)	2.08
" The As-HAE induced cytotoxicity on PBMCs determined by trypan blue dye exclusion (CC50 = 653 μg/mL) and MTT (CC50 = 588 μg/mL) assays being more toxic than cold extract."	( In Vitro and In Vivo Cytogenotoxic Effects of Hot Aqueous Extract of Achyrocline satureioides (Lam.) DC. Bacchetti, R; Cariddi, LN; Comini, LR; Escobar, FM; Merckis, C; Montironi, I; Núñez Montoya, S; Reinoso, EB; Sabini, LI; Sabini, MC; Zanon, SM, 2015)	0.42
" From the present findings, it can be evaluated that quercetin may protect against adverse effects resulted from multi-organophosphorous pesticides with significant high levels of uptake in man provided."	( Effect of quercetin against mixture of four organophosphate pesticides induced nephrotoxicity in rats. Cao, C; Li, S; Qi, L; Shi, H; Sun, C; Yang, S; Zhao, X, 2016)	1.09
" However, QR administration ameliorated FNT-induced toxic effects."	( Quercetin mitigates fenitrothion-induced testicular toxicity in rats. Abd El-Aziz, RM; Ali, HA; Saber, TM, 2016)	1.88
" Treatment of MGO for 24 h significantly enhanced 3-h OGD-induced HBMEC toxic effect, which was inhibited by pretreatment of isorhamnetin (100 μmol/L)."	( The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation. Chen, Z; Dai, H; He, P; Li, W; Yan, M, 2016)	0.43
" Rats-administered querectin along with ZnONPs showed less toxic effects on all studied reproductive traits and mRNA transcripts."	( Querectin Alleviates Zinc Oxide Nanoreprotoxicity in Male Albino Rats. Ahmed, MM; Ali, HA; Hussein, MM; Saadeldin, IM, 2016)	0.43
"The present study aims to investigate the protective effect of quercetin against the joint toxic action induced by the mixture of four organophosphate pesticides (mixture-OPs) (dimethoate, acephate, dichlorvos, and phorate) at their corresponding no observed adverse effect level (NOAEL) using metabonomics."	( Metabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine. Cao, C; Chen, S; Hu, L; Qi, L; Sun, C; Zhao, X, 2017)	0.95
" Based on a favorable safety profile, it has been confirmed as generally recognized as safe (GRAS) compound by the FDA."	( Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rats. Davis, JP; Hayashi, SM; Jokinen, MP; Koyanagi, M; Maronpot, RR; Nyska, A; Ramot, Y, 2016)	0.43
" Several studies have reported of toxic effects of Q against glioma cell lines."	( Quercetin derivatives as potent inducers of selective cytotoxicity in glioma cells. Dell'Albani, P; Di Marco, B; Foti, MC; Grasso, S; Rocco, C, 2017)	1.9
"Repeated Mn administration induces toxic effects in several rat brain structures and treatment with R and QCT may be a potential therapeutic strategy to attenuate the metal neurotoxicity."	( Manganese neurotoxicity and protective effects of resveratrol and quercetin in preclinical research. Filip, M; Gawlik, M; Gawlik, MB; Smaga, I, 2017)	0.69
" We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy."	( Protective Effect of Quercetin Against Oxidative Stress-induced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue. Dogan, Z; Erdemli, E; Kocahan, S; Taskin, E, 2017)	1.09
" Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI."	( Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells. Andreucci, M; De Sarro, G; Faga, T; Michael, A; Pisani, A; Russo, D; Serra, R, 2018)	1.92
"Doxorubicin (Dox) is an efficient drug for breast cancer chemotherapy, however, its toxic side effects on non-tumor tissues, especially on myocardial cells, sometimes limit its clinical application."	( Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. Li, K; Li, S; Wang, B; Wang, X; Yuan, S; Zhao, Q, 2018)	1.92
" Interestingly, co-administration with low dose QT or different doses of LC succeeded to counteract the negative toxic effects of ATZ on serum oxidative stress indicators, serum testosterone levels, testicular IgA level and improved testicular CYP17A1 mRNA expression."	( Dose- dependent ameliorative effects of quercetin and l-Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats. Abdel Aziz, RL; Abdel-Wahab, A; Abo El-Ela, FI; El-Nahass, ES; Hassan, NEY; Ibrahim, MA; Khalil, AAY, 2018)	0.75
"Recent studies have demonstrated that bisphenol A (BPA) has an adverse or toxic effect on the kidney."	( The ameliorative effect of quercetin on bisphenol A-induced toxicity in mitochondria isolated from rats. Alizadeh, S; Dehghani, MA; Mahdavinia, M; Shirani, M, 2019)	0.81
" As a result, CPF was found to exert a significant toxic effect on BV2 cells that was characterized by rounded cell body, atrophic synapse, poor adhesion, cell aggregation, inflammation, oxidative reaction, and autophagy."	( Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells. Dai, H; Deng, Y; Zhan, J; Zhang, C; Zhao, L; Zhao, M; Zhou, W, 2019)	0.51
" Treatment of TAA intoxicated rats (G4) with MOLE ameliorated the toxic effects of TAA on hepatic tissue structure and function."	( Protective effect of Moringa oleifera leaves ethanolic extract against thioacetamide-induced hepatotoxicity in rats via modulation of cellular antioxidant, apoptotic and inflammatory markers. El Sabagh, HS; El-Gansh, HAI; Eldaim, MAA; Mohamed, MAE; Morsi, AH; Mousa, AA, 2019)	0.51
" There were no toxic chemicals involved during the synthesis."	( Green Synthetic Nanoarchitectonics of Gold and Silver Nanoparticles Prepared Using Quercetin and Their Cytotoxicity and Catalytic Applications. Lee, YJ; Park, Y, 2020)	0.78
"Acute renal failure induced by a toxic dose of acetaminophen (also known as paracetamol, or APAP) is common in both humans and experimental animal models."	( Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin. Abdel Kader, DH; Al-Ani, B; Dallak, M; Dawood, AF; Eid, RA; Haidara, MA; Kamar, SS; Shams Eldeen, AM, 2022)	0.92
"Patients had no study drug-related severe adverse events based on blood tests, which included both complete blood counts and evaluation of comprehensive metabolic panel."	( Randomised clinical trial to determine the safety of quercetin supplementation in patients with chronic obstructive pulmonary disease. Barreto, TA; Comstock, AT; Han, MK; Martinez, FJ; Sajjan, US, 2020)	0.81
" Endosulfan, a highly toxic organochlorine insecticide, causes cytotoxic cell death by inducing oxidative stress."	( Oxidative stress-mediated cytotoxicity of Endosulfan is causally linked to the inhibition of NADH dehydrogenase and Na Carvalho, MS; Murali, M; Shivanandappa, T, 2020)	0.56
" The data reported here support the hypothesis that QUE rescues the toxic effects of DON or 15ADON due to the similar mechanisms of DON and 15ADON toxicity."	( Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis. Jia, BX; Liu, N; Wu, A; Yang, YX; Yu, S, 2020)	0.78
"Cadmium (Cd), a highly toxic heavy metal, adversely affects human and animal health."	( Protective effect of quercetin on rat testes against cadmium toxicity by alleviating oxidative stress and autophagy. Liu, Z; Wang, J; Wang, K; Yang, Z; Zhu, H, 2020)	0.88
" Administration of quercetin is advantageous in reducing the adverse effects of cisplatin without compromising its anti-tumour activity."	( Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review. Ashrafizadeh, M; Najafi, M; Tavakol, S; Zarrabi, A, 2022)	1.42
" In the present study, we examined the toxic effects of lead acetate (Pb) on testicular structure and the possible effect of quercetin on mitigating these effects."	( Protective Effect of Quercetin on Testis Structure and Apoptosis Against Lead Acetate Toxicity: an Stereological Study. Alaee, S; Azarpira, N; Bordbar, H; Dolati, P; Jamhiri, I; Khodabandeh, Z; Mehrabani, D; Zamiri, MJ, 2021)	1.15
"Previous studies have demonstrated the toxic impacts of zinc oxide nanoparticles (ZO-NPs) on male reproductive cells."	( Quercetin ameliorates cytotoxic effects of zinc oxide nanoparticles on sertoli cells by enhancing autophagy and suppressing oxidative stress. Karimi, S; Khorsandi, L; Zeinvand-Lorestani, M, 2021)	2.06
" Thus, GlukvamineTM is a promising effective and safe drug for pharmacological correction of the hepatotoxicity of MTX."	( The hepatoprotective effect of the combination of glucosamine derivatives with quercetin against methotrexate-induced liver toxicity. Sakharova, TS; Vietrova, KV; Zupanets, IA, 2020)	0.79
" Its most common dose-limiting adverse effect is nephrotoxicity."	( Effect of taxifolin/dapagliflozin combination on colistin-induced nephrotoxicity in rats. Kabel, AM; Salama, SA, 2021)	0.62
" The aim of the present study was to examine the toxic effects of lead acetate on fertility in male mice and their offspring, and the potential effect of quercetin on mitigating the likely effects."	( Reproductive and embryological toxicity of lead acetate in male mice and their offspring and mitigation effects of quercetin. Akhlaghi, A; Atashi, H; Dolati, P; Jamhiri, I; Khodabandeh, Z; Mehrabani, D; Zamiri, MJ, 2021)	1.03
" The findings suggest that sub-lethal concentration of cypermethrin is toxic to fish."	( Cassia fistula ameliorates chronic toxicity of cypermethrin in Catla catla. Faggio, C; Jindal, R; Sharma, R, 2021)	0.62
"Cadmium (Cd), an environmental toxic heavy metal, has been reported to cause testicular toxicity, which contributes to the recent decline in male fertility worldwide."	( Quercetin mediated attenuation of cadmium-induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro. Bhardwaj, JK; Panchal, H, 2021)	2.06
"Various natural compounds have been successfully tested for preventing or counteracting the toxic effects of exposure to heavy metals."	( Quercetin Protects Human Thyroid Cells against Cadmium Toxicity. Bulotta, S; Capriglione, F; Celano, M; Damante, G; Maggisano, V; Maiuolo, J; Russo, D, 2021)	2.06
"Lead (Pb) is a common toxic heavy metal pollutant in the environment that seriously endangers the health of animals."	( Quercetin and Allicin Can Alleviate the Hepatotoxicity of Lead (Pb) through the PI3K Signaling Pathway. Bai, Y; Bian, J; Cai, P; Cao, Q; Gu, J; Liu, X; Liu, Z; Yuan, Y; Zhu, Q; Zou, H, 2021)	2.06
" This study aimed to explore the potential of the quercetin (QUR) loaded magnetic nano-micelles for improving drug bioavailability while reducing the drug adverse effects."	( Self-assembled magnetic polymeric micelles for delivery of quercetin: Toxicity evaluation on isolated rat liver mitochondria. Hosseini, MJ; Kermanian, M; Rahmati, MA; Rashidzadeh, H; Sadighian, S, 2022)	1.22
"Doxorubicin combined with cyclophosphamide (AC) is the most commonly used regimen for triple-negative breast cancer (TNBC) chemotherapy; however, its clinical application is severely limited by its serious adverse effect on cardiomyocytes."	( Quercetin attenuates the cardiotoxicity of doxorubicin-cyclophosphamide regimen and potentiates its chemotherapeutic effect against triple-negative breast cancer. Li, K; Li, S; Zhang, J; Zhang, P; Zhao, L, 2022)	2.16
" In our study, first, toxic doses of acrylamide, nontoxic doses of thymoquinone and quercetin in C6 cells for 24 h were determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) colorimetric test."	( The effects of thymoquinone and quercetin on the toxicity of acrylamide in rat glioma cells. Kacar, S; Kutlu, HM; Sahinturk, V; Tomsuk, O, 2022)	1.23
" No serious adverse events or toxicity were reported in the clinical or experimental animal studies we reviewed."	( United States Pharmacopeia comprehensive safety review of Styphnolobium japonicum flower and flower bud. Calderón, AI; Madden, E; McLachlan, C; Oketch-Rabah, H, 2022)	0.72
" Schizophrenia (SZ) is one of the neuropsychiatric disorders in human beings with rapid mortality and intense morbidity which can be treated with antipsychotics, but these commercial drugs exert adverse effects and have less efficacy to treat the full spectrum of SZ."	( Reversal of oxidative stress, cytokine toxicity and DNA fragmentation by quercetin in dizocilpine-induced animal model of Schizophrenia. Afzal, A; Batool, Z; Haider, S; Shahzad, S, 2022)	0.95
" LA could be precisely released in the acidic tumor microenvironment for activating nontoxic QU successfully to produce toxic oxidized quercetin (OQU), and the LA was steady loaded on the LA@ZIF-8 under physiological conditions (pH∼7."	( The safe Laccase@ZIF-8-prodrug system with GSH redox cycle for effective targeted cancer therapy with low off-target toxicity. He, Z; Qi, W; Su, R; Wang, Y; Yan, X; You, S; Zhang, C; Zhang, J; Zhou, Y, 2022)	0.92
" Overall, TEGDMA induces various toxic effects in macrophages, including cytotoxicity, apoptosis, and genotoxicity."	( Protective Effect of Rutin on Triethylene Glycol Dimethacrylate-Induced Toxicity through the Inhibition of Caspase Activation and Reactive Oxygen Species Generation in Macrophages. Chang, YC; Huang, FM; Kuan, YH; Su, NY; Yang, LC; Yeh, KL, 2022)	0.72
" The main purpose of this study was to determine if quercetin has any toxic properties in mice at doses that have shown efficacy in pre-clinical studies regarding cancer, cancer therapy, and their off-target effects."	( Sub-chronic oral toxicity screening of quercetin in mice. Aladhami, A; Chatzistamou, I; Cunningham, P; Enos, RT; Fan, D; Madero, S; Murphy, EA; Patton, E; Unger, C; VanderVeen, BN; Velázquez, KT, 2022)	1.24
"In summary, our study establishes that quercetin is safe for use in both female and male CD2F1 mice when given at ~ 12."	( Sub-chronic oral toxicity screening of quercetin in mice. Aladhami, A; Chatzistamou, I; Cunningham, P; Enos, RT; Fan, D; Madero, S; Murphy, EA; Patton, E; Unger, C; VanderVeen, BN; Velázquez, KT, 2022)	1.26
" Interestingly, quercetin displays toxic properties against phylogenetically distant organisms such as bacteria and eukaryotic cells, suggesting that its molecular target resides on a highly conserved pathway."	( Cytotoxicity of quercetin is related to mitochondrial respiration impairment in Saccharomyces cerevisiae. Arvizu-Medrano, SM; Canizal-Garcia, M; Carrillo-Garmendia, A; González-Hernández, JC; Gracida, J; Madrigal-Perez, LA; Martinez-Ortiz, C; Regalado-Gonzalez, C, 2022)	1.41
" The interactions between QC and nanoparticles caused the nanocomposite pH-responsive behavior that assists in minimizing the side effect of the anticancer agent by controlling the burst release of QC at neutral conditions."	( Development of chitosan/halloysite/graphitic‑carbon nitride nanovehicle for targeted delivery of quercetin to enhance its limitation in cancer therapy: An in vitro cytotoxicity against MCF-7 cells. Khadiv-Parsi, P; Pourmadadi, M; Rashedi, H; Sabzini, M; Yazdian, F, 2023)	1.13
" However, compounds QMJ-2, QMJ-5, and NMJ-1 were cardiotoxic and the concentration needs to be reduced to prevent toxic effects on cardiomyocytes."	( An efficient human stem cells derived cardiotoxicity testing platform for testing oncotherapeutic analogues of quercetin and cinnamic acid. Biswas, S; Gamit, N; Mandal, S; Rao, CM; Sethi, G; Warrier, S, 2022)	0.93
" The addition of dietary polyphenols did not increase adverse events."	( Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials. Chen, Y; Deng, Y; Guo, H; He, Q; Huang, Z; Li, H; Long, Z; Wei, H; Xiang, W; Xiao, W; Yang, K; Yuan, M; Yuan, X; Zeng, L, 2023)	0.91
" Hence, man faces the risk of exposure to ZnO-NPs and the consequent adverse health effects."	( Protective effect of quercetin and thymoquinone against genotoxicity and oxidative stress induced by ZnO nanoparticles in the Wistar rat model. Ahmad, MF; Akbarsha, MA; Ansari, MO; Latif Wani, AB; Parveen, N; Shadab, GGHA, )	0.45

Pharmacokinetics

A nanodroplet formulation was prepared and loaded with a novel class of chemotherapeutic drug. Time to reach Cmax (tmax) was significantly shorter after the quercetin aglycone treatment than after the rutin treatment. The pharmacokinetic model fitted well the observed data of quercetus and its conjugates.

Excerpt	Reference	Relevance
" The median elimination half-life times of hypericin were 24."	( Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. Brockmöller, J; Kerb, R; Ploch, M; Roots, I; Staffeldt, B, 1994)	0.29
"A double-blind, randomized, placebo-controlled parallel-group trial (phase I) was performed to evaluate the central pharmacodynamic effects of two hypericum extracts with different contents of hyperforin (0."	( Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG. Dimpfel, W; Sauer, S; Schellenberg, R, 1998)	0.3
" The pharmacokinetic parameters following intravenous injection were determined in two studies."	( Pharmacokinetics and bioavailability of the flavonol quercetin in humans. Derendorf, H; Graefe, EU; Veit, M, 1999)	0.55
" However, time to reach Cmax (tmax) was significantly shorter after the quercetin aglycone treatment than after the rutin treatment (1."	( Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Alfthan, G; Aro, A; Erlund, I; Kenraali, J; Kosonen, T; Mäenpää, J; Parantainen, J; Perttunen, K, 2000)	0.86
" There was no significant difference in the bioavailability and pharmacokinetic parameters between the onion supplement and quercetin-4'-O-glucoside."	( Pharmacokinetics and bioavailability of quercetin glycosides in humans. Derendorf, H; Drewelow, B; Graefe, EU; Jacobasch, G; Mueller, S; Pforte, H; Riethling, AK; Uehleke, B; Veit, M; Wittig, J, 2001)	0.78
" Pharmacokinetic parameters of camptothecin were assessed using a non-compartmental model."	( Effect of P-glycoprotein modulators on the pharmacokinetics of camptothecin using microdialysis. Lee, CH; Tsai, TH; Yeh, PH, 2001)	0.31
" The present pharmacokinetic study was designed to find out whether the improved water solubility in the presence of procyanidin B2 or hyperoside is correlated to increased plasma levels of hypericin."	( Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats. Butterweck, V; Liefländer-Wulf, U; Nahrstedt, A; Winterhoff, H, 2003)	0.32
" Pharmacokinetic parameters of verapamil and norverapamil were determined after the oral administration of verapamil (10 mg kg(-1)) to rabbits in the presence and absence of quercetin (5."	( The effect of quercetin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rabbits. Choi, JS; Han, HK, 2004)	0.88
"To determine the pharmacokinetics of quercetin and its glucuronide/sulfate conjugates and to develop a pharmacokinetic model to simultaneously describe their disposition after intravenous and oral administration in rats."	( Pharmacokinetics and modeling of quercetin and metabolites. Chen, X; Chow, MS; Yin, OQ; Zuo, Z, 2005)	0.88
" The pharmacokinetic model fitted well the observed data of quercetin and its conjugates."	( Pharmacokinetics and modeling of quercetin and metabolites. Chen, X; Chow, MS; Yin, OQ; Zuo, Z, 2005)	0.85
" The pharmacokinetic model appears to be suitable for describing the absorption and disposition of the quercetin and its conjugates and may be applicable to other flavonoids that undergo similar pharmacokinetic pathways."	( Pharmacokinetics and modeling of quercetin and metabolites. Chen, X; Chow, MS; Yin, OQ; Zuo, Z, 2005)	0.82
" Therefore, the objective of the two open phase I clinical trials was to obtain pharmacokinetic data of these constituents from a hypericum extract containing tablet: hypericin, pseudohypericin, hyperforin, the flavonoid aglycone quercetin, and its methylated form isorhamnetin."	( Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers. Bässler, D; Schulz, HU; Schürer, M; Weiser, D, 2005)	0.73
" In the present study, we have investigated the pharmacokinetic profiles of isorhamnetin after oral application in rats equipped with a jugular catheter."	( Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin. He, J; Jiang, X; Lan, K, 2007)	0.6
"Little is known regarding pharmacokinetic (PK) or pharmacodynamic interactions of flavonoids with each other: this is of significance since multiple flavonoids are present in the diet and in dietary supplements."	( Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Moon, YJ; Morris, ME, )	0.36
" The validated method was successfully applied to pharmacokinetic studies of the two analytes in rat plasma after the oral administration of Hypericum japonicum thunb."	( HPLC analysis and pharmacokinetic study of quercitrin and isoquercitrin in rat plasma after administration of Hypericum japonicum thunb. extract. Bi, KS; Chen, XH; Li, J; Liu, X; Wang, ZW; Zhang, L, 2008)	0.35
"The purpose of this study was to examine the pharmacokinetics of quercetin aglycone as well as its conjugated metabolites and to develop a population pharmacokinetic model for quercetin that incorporates enterohepatic recirculation."	( Quercetin pharmacokinetics in humans. DiCenzo, R; Moon, YJ; Morris, ME; Wang, L, 2008)	2.03
" pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data."	( Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Lombardo, F; Obach, RS; Waters, NJ, 2008)	0.35
" A reliable sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method with UV detection for the pharmacokinetic study of taxifolin in rabbit plasma after enzymatic hydrolysis was developed and validated for the first time."	( Determination and pharmacokinetic study of taxifolin in rabbit plasma by high-performance liquid chromatography. Karlina, MV; Kosman, VM; Makarov, VG; Makarova, MN; Pozharitskaya, ON; Shikov, AN, 2009)	0.35
" Plasma and urinary fexofenadine concentrations were measured, and pharmacokinetic differences between placebo and quercetin phases were assessed."	( Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers. Kim, KA; Park, JY; Park, PW, 2009)	0.88
" The area under the time versus concentration curve (AUC) of plasma fexofenadine was increased by 55% by quercetin (2,005."	( Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers. Kim, KA; Park, JY; Park, PW, 2009)	0.89
" Treatment with rutin significantly decreased the elimination half-life of S-warfarin by 37% as a result of the 69% increase in unbound clearance of the S-enantiomer."	( Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. Chan, E; Chen, X; Hegde, A, 2009)	0.35
"Concurrent rutin administration is likely to reduce the anticoagulant effect of racemic warfarin, reflecting a significant decrease in the elimination half-life of the more potent S-enantiomer."	( Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. Chan, E; Chen, X; Hegde, A, 2009)	0.35
" Pharmacokinetic parameters were calculated using the software WinNonlin Standard Edition Version."	( Lymphatic absorption of quercetin and rutin in rat and their pharmacokinetics in systemic plasma. Chen, IL; Huang, CM; Tsai, TH; Tsai, YJ, 2010)	0.67
"The pharmacokinetic parameters of diazepam and one of its metabolites, N-demethyldiazepam, were compared after oral administration of diazepam (10 mg) in the absence or presence of oral GBE (120 mg bid, for 28 days) in 12 healthy volunteers."	( Effects of Ginkgo biloba extracts on diazepam metabolism: a pharmacokinetic study in healthy Chinese male subjects. Chen, BM; Dai, LL; Jia, SJ; Li, J; Liu, SK; Yang, GP; Yuan, H; Zhang, BK; Zhang, J; Zhou, LY; Zuo, XC, 2010)	0.36
"The 90% confidence intervals (CIs) of the ratios of mean pharmacokinetic parameters of diazepam presence and absence of GBE were well within the 80-125% bioequivalence range, indicating no pharmacokinetic interaction."	( Effects of Ginkgo biloba extracts on diazepam metabolism: a pharmacokinetic study in healthy Chinese male subjects. Chen, BM; Dai, LL; Jia, SJ; Li, J; Liu, SK; Yang, GP; Yuan, H; Zhang, BK; Zhang, J; Zhou, LY; Zuo, XC, 2010)	0.36
"A simple and specific high-performance liquid chromatographic (HPLC) method was developed for the pharmacokinetic study of hyperoside (HP, isolated from the leaves of Crataegus pinnatifida Bge."	( LC determination and pharmacokinetic study of hyperoside in rat plasma after intravenous administration. Kang, TG; Liu, X; Meng, XS; Wang, D; Wang, SY; Ying, XX; Zhang, WJ, 2010)	0.36
" Then we studied the pharmacokinetic characteristics and bioavailability in rats."	( Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. Cai, BC; Cai, H; Chen, HX; Chen, J; Chen, ZP; Liu, D; Sun, J; Xiao, YY, 2010)	0.6
"The chirality of flavonoids has been overlooked in the majority of pharmacokinetic studies of homoeriodictyol, isosakuranetin, and taxifolin."	( Stereospecific pharmacokinetics of racemic homoeriodictyol, isosakuranetin, and taxifolin in rats and their disposition in fruit. Andrews, PK; Davies, NM; Ohgami, Y; Remsberg, CM; Takemoto, JK; Vega-Villa, KR; Yáñez, JA, 2011)	0.37
" To investigate the pharmacokinetic profile of total quercetin after a single oral dose of tartary buckwheat extract in rats, a sensitive, simple, and accurate HPLC-UV method was developed to determine total quercertin following plasma enzyme hydrolysis with glucuronidase/sulfatase."	( Pharmacokinetic profile of total quercetin after single oral dose of tartary buckwheat extracts in rats. Hu, H; Hu, Y; Peng, L; Wang, Z; Zhao, G; Zou, L, 2011)	0.9
" The developed-method was successfully applied for the pharmacokinetic study of PMQ and its metabolite TMQ in dogs following a single oral dose."	( Simultaneous determination of 3,3',4',5,7-pentamethylquercetin and its possible metabolite 3,3',4',7-tetramethylquercetin in dog plasma by liquid chromatography-tandem mass spectrometry and its application to preclinical pharmacokinetic study. Chen, X; Hu, Y; Jin, M; Li, D; Peng, K; Zheng, H; Zhou, L, 2011)	0.62
" The main pharmacokinetic parameters were as follows: T(1/2z) was 92."	( [Study on determination and pharmacokinetics of metabolites from Folium Mori extract in rats]. Jiang, LD; Lou, XF; Xuan, GD; Zhao, L; Zhu, YF, 2011)	0.37
"The method established in this study is accurate, reliable and reproducible, and can be applied for determination of total quercetin, kaempferol and isorhamnetin in rat plasma after oral administration of FME; the pharmacokinetic studies showed that the distribution of drugs is rapid and elimination is very slow."	( [Study on determination and pharmacokinetics of metabolites from Folium Mori extract in rats]. Jiang, LD; Lou, XF; Xuan, GD; Zhao, L; Zhu, YF, 2011)	0.58
" Quercetin significantly increases the plasma concentration of valsartan and peak concentration (70."	( Pharmacokinetic interaction study between quercetin and valsartan in rats and in vitro models. Babu, PR; Challa, SR; Challa, VR; Johnson, B; Maheswari, C, 2013)	1.56
" The results of this study indicated the SD formulations on the improvement of pharmacokinetic properties of isorhamnetin, quercetin and kaempferol in TFH were much better than those of SE formulations."	( Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. Duan, J; Li, G; Lin, G; Luo, H; Xie, Y; Yuan, X; Zhao, G, 2013)	0.8
" Quercetin increased the peak concentration (Cmax) of ranolazine from 254 ± 8."	( Influence of quercetin on the pharmacokinetics of ranolazine in rats and in vitro models. Babu, KN; Babu, PJ; Babu, PR; Peter, PL; Rajesh, K, 2013)	1.67
" Pharmacokinetic parameters were determined by noncompartmental modeling using Kinetica software."	( Comparison of quercetin pharmacokinetics following oral supplementation in humans. Clarkson, PM; Conca, KR; Dunne, CP; Kaushik, D; Michniak-Kohn, B; O'Fallon, K, 2012)	0.74
"In this study, we investigated pharmacokinetic drug interactions of clopidogrel with P-gp inhibitors in rats and dogs."	( Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs. Lee, JH; Lee, YJ; Oh, JH; Shin, YJ, 2012)	0.63
"To establish a method to determine the concentration of formononetin, calycosin and isorhamnetin from Astragalus mongholicus in rats' plasma using LC-MS/MS and calculate their pharmacokinetic parameters."	( [Simultaneous determination of formononetin, calycosin and isorhamnetin from Astragalus mongholicus in rat plasma by LC-MS/MS and application to pharmacokinetic study]. Li, Y; Lin, Q; Tan, XM; Yao, XC, 2013)	0.39
" The pharmacokinetic parameter, t(1/2beta), of formononetin, calycosin and isorhamnetin was (10."	( [Simultaneous determination of formononetin, calycosin and isorhamnetin from Astragalus mongholicus in rat plasma by LC-MS/MS and application to pharmacokinetic study]. Li, Y; Lin, Q; Tan, XM; Yao, XC, 2013)	0.39
"A sensitive, accuracy and suitable LC-MS/MS method for determination of formononetin, calycosin and isorhamnetin is developed and successfully applied to the pharmacokinetic study of 10 g/kg Astragalus mongholicus after oral administration in rats."	( [Simultaneous determination of formononetin, calycosin and isorhamnetin from Astragalus mongholicus in rat plasma by LC-MS/MS and application to pharmacokinetic study]. Li, Y; Lin, Q; Tan, XM; Yao, XC, 2013)	0.39
"6% in 5 subjects and cmax was decreased by 29."	( Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans - Implications for the evaluation of transporter-mediated flavonoid-drug interactions. Langguth, P; Nguyen, MA; Staubach, P; Wolffram, S, 2014)	0.65
" Pharmacokinetic study was investigated in the two groups of rats (n = 6) for pharmacokinetic interactions between the Quercetin and Rutin (2."	( Comparative pharmacokinetic interactions of Quercetin and Rutin in rats after oral administration of European patented formulation containing Hipphophae rhamnoides and Co-administration of Quercetin and Rutin. Agrawal, A; Chintala, J; Dubey, GP; Kaliappan, I; Kammalla, AK; Ramasamy, MK, 2015)	0.89
" The pharmacokinetic results showed that C max of isorhamnetin and quercetin in TFH solid dispersion (TFH-SD) and TFH self-emulsifying (TFH-SE) preparations was significantly enhanced than that in TFH preparations (p < 0."	( A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration. Dang, Y; Duan, J; Li, G; Ma, P; Meng, H; Wang, H; Wu, T; Xie, Y, 2016)	0.67
" In this study, a nanodroplet formulation was prepared and loaded with a novel class of chemotherapeutic drug, ie, quercetin, to observe its pharmacokinetic properties and ultrasonic bioimaging of specific sites, namely the abdominal vein and bladder."	( Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging. Chang, LW; Hou, ML; Hung, SH; Lin, LC; Tsai, TH, 2015)	0.95
" The validated method has been successfully applied to pharmacokinetic studies of the three analytes following intragastric administration of Eupatorium lindleyanum extract at a single dose of 100, 250, and 625mg/kg to Sprague-Dawley rats, respectively."	( Pharmacokinetics of eupalinolide A, eupalinolide B and hyperoside from Eupatorium lindleyanum in rats by LC/MS/MS. Lu, X; Yu, X; Zhang, J; Zhao, F; Zheng, G, 2015)	0.42
" Pretreatment with verapamil increased the peak concentration and area under the concentration-time curve of hyperin, which were significantly higher than the control values."	( Simultaneous quantification of hyperin, reynoutrin and guaijaverin in mice plasma by LC-MS/MS: application to a pharmacokinetic study. Guo, J; Li, Z; Meng, F; Peng, S; Sun, L; Yu, L; Zhang, Y; Zhang, Z, 2016)	0.43
"A rapid and sensitive LC-MS/MS method with good accuracy and precision was developed and validated for the pharmacokinetic study of quercetin-3-O-β-d-glucopyranosyl-7-O-β-d-gentiobioside (QGG) in Sprague-Dawley rats."	( A rapid and sensitive LC-MS/MS method for quantification of quercetin-3-O-β-d-glucopyranosyl-7-O-β-d-gentiobioside in plasma and its application to a pharmacokinetic study. Gao, H; He, X; Li, K; Sun, L; Tao, G; Zhang, Y, 2016)	0.88
"Xiebai in Gualou Xiebai decoction has a remarkable effect on pharmacokinetic character of quercetin in Gualou, it can promote the absorption and distribution and reduce the elimination of quercetin, in vivo, as well as increase the bioavailability of quercetin."	( [Influence of the Compatibility of Gualou and Xiebai on Pharmacokinetics of Quercetin in Gualou]. Chen, XJ; Huang, X; Wei, ML; Yan, HY; Zhang, YH; Zou, CC, 2015)	0.87
" For quercetin, the pharmacokinetic parameter t(½β), AUC(0-∞), MRT(0."	( [Determination of plasma concentration of quercetin, kaempferid and isorhamnetin in Hippophae rhamnoides extract by HPLC-MS/MS and pharmacokinetics in rats]. Liu, Y; Meng, XL; Tuo, YL; Wang, P; Wei, T; Yang, J; Zeng, Y, 2015)	1.2
" The present LC-MS/MS method was successfully applied to pharmacokinetic studies of taxifolin after intravenous administration of taxifolin, oral administration of its physical mixture and nanodispersion."	( UHPLC-MS/MS Determination, Pharmacokinetic, and Bioavailability Study of Taxifolin in Rat Plasma after Oral Administration of its Nanodispersion. Gao, MJ; Kuang, HX; Lv, JN; Meng, YH; Mi, YY; Wang, ZB; Yang, BY; Yang, CJ, 2016)	0.43
" An in vivo pharmacokinetic study demonstrated that Que-LMPMs had higher area under the concentration-time curve and a longer half-life, leading to better bioavailability compared to a free Que injection."	( Development and characterization of self-assembling lecithin-based mixed polymeric micelles containing quercetin in cancer treatment and an in vivo pharmacokinetic study. Chen, LC; Chen, YC; Ho, HO; Hong, CS; Sheu, MT; Su, CY, 2016)	0.65
"The aim of the present study was to evaluate whether quercetin (Que) modulates the mRNA and protein expression levels of drug‑metabolizing enzymes (DMEs) and drug transporters (DTs) in the small intestine and liver, and thus modifies the pharmacokinetic profile of cyclosporine (CsA) in rats."	( Impact of quercetin‑induced changes in drug‑metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats. Liu, Y; Luo, X; Shi, S; Yang, C; Yang, T; Zhou, J, 2016)	1.09
" The difference in outcomes was vivid in pharmacokinetic studies, where nanoparticles, esp."	( Promises of a biocompatible nanocarrier in improved brain delivery of quercetin: Biochemical, pharmacokinetic and biodistribution evidences. Katare, OP; Kumar, P; Kumar, R; Malik, R; Raza, K; Sharma, G; Singh, B, 2016)	0.67
" By considering pharmacokinetic aspects, the present study was undertaken to evaluate the effects of caffeic acid and quercetin on Caco-2 cells permeability, metabolism, CYP1A inhibition in vitro assay systems and a single dose pharmacokinetics of melatonin in vivo rats."	( Effects of Caffeic Acid and Quercetin on In Vitro Permeability, Metabolism and In Vivo Pharmacokinetics of Melatonin in Rats: Potential for Herb-Drug Interaction. Jana, S; Rastogi, H, 2017)	0.96
" Derivatives of imidazole, 1,3-thiazole and pyrimidine proved to be more potent than febuxostat while also displaying/possessing favorable predicted physico-chemical, pharmacokinetic and toxicological properties."	( Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity. Anderluh, M; Jakopin, Ž; Kocić, G; Petronijević, Ž; Šmelcerović, A; Šmelcerović, Ž; Tomašič, T; Tomović, K, 2017)	0.46
" An 8-h pharmacokinetic study was performed."	( Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Chen, TY; Cooper, B; Ferruzzi, MG; Ho, L; Janle, EM; Pasinetti, GM; Simon, JE; Talcott, ST; Todd, G; Wang, J; Wu, QL, 2017)	0.46
" The method was validated and successfully applied to everted sac and pharmacokinetic studies in rats."	( HPLC Estimation, Ex vivo Everted Sac Permeability and In Vivo Pharmacokinetic Studies of Darunavir. Sangave, PC; Suvarna, VM, 2018)	0.48
"To estabish ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for simultaneous determination of quercetin(QCT), isorhamnetin(ISR), kaempferol(KMF), ginkgolide A(GA), ginkgolide B(GB), ginkgolide C(GC) and bilobalide(BB) in rat plasma and investigate the pharmacokinetic process of seven compounds after oral administration of Yindan Xinnaotong Ruanjiaonang, The results indicated that all calibrations curves showed good linearity (r≥0."	( [Simultaneous determination of seven bioactive compounds and pharmacokinetics in rat plasma after oral administration of Yindan Xinnaotong Ruanjiaonang by UPLC-MS/MS]. Gong, LL; Liang, RX; Wang, L; Xu, HY; Yang, HJ; Yin, XJ; Yuan, HJ, 2017)	0.66
" Quercetin altered pharmacokinetic of enrofloxacin by decreasing area under curve, peak concentration, and time to reach peak concentration and by increasing clearance rate."	( Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken. Bhutto, ZA; Guo, T; He, F; Huang, J; Wang, L; Yang, J; Zloh, M, 2018)	1.85
"To study the pharmacokinetic and tissue distribution of quercetin injection and submicron emulsion after intravenous administration in mice."	( [Study on Pharmacokinetics and Tissue Distribution of Quercetin Submicroemulsion in Mice]. Duan, X; Guo, QT; Song, X; Tang, ZS; Wang, CL; Zhao, P, 2016)	0.93
"Quercetin submicron emulsion significantly alters the plasma pharmacokinetic characteristics of quercetin after intravenous administration in mice."	( [Study on Pharmacokinetics and Tissue Distribution of Quercetin Submicroemulsion in Mice]. Duan, X; Guo, QT; Song, X; Tang, ZS; Wang, CL; Zhao, P, 2016)	2.13
"To develop a sensitive and reliable ultra performance liquid chromatography tandem mass spectrometry ( UPLC-MS / MS) method for simultaneous determination and pharmacokinetics of protocatechuic acid, kaempferol biotin glucoside and quercitrin in rat plasma, and study their pharmacokinetic characteristics in rats."	( [Simultaneous Determination of Protocatechuic Acid,Kaempferol Biotin Glucoside and Quercitrin in Rat Plasma and Pharmacokinetics By UPLC-MS/MS]. Chen, SY; Li, YJ; Sun, J; Xiang, WY; Yang, W; Zheng, L, 2016)	0.43
"The established method is specific,rapid,accurate and sensitive,and is proved to meet the requirements of biological sample analyses,and is suitable for the concentration determination of protocatechuic acid, kaempferol biotin glucoside and quercitrin in rat plasma, three compounds are all best fitted to the two-compartment open pharmacokinetic model."	( [Simultaneous Determination of Protocatechuic Acid,Kaempferol Biotin Glucoside and Quercitrin in Rat Plasma and Pharmacokinetics By UPLC-MS/MS]. Chen, SY; Li, YJ; Sun, J; Xiang, WY; Yang, W; Zheng, L, 2016)	0.43
" The current study aimed to investigate the impact of co-administration of pomegranate peel and guava leaves extracts, including their quality markers namely; ellagic acid and quercetin, respectively, on warfarin's in vivo dynamic activity and pharmacokinetic actions, in addition to potential in vitro cytochrome P450 enzymes (CYP) inhibition."	( Critical pharmacokinetic and pharmacodynamic drug-herb interactions in rats between warfarin and pomegranate peel or guava leaves extracts. Alnaqeeb, M; Ghanim, BY; Idkaidek, N; Mallah, EM; Mansor, KA; Qinna, NA, 2019)	0.71
"Influence of mentioned extracts and their key constituents on warfarin pharmacodynamic and kinetic actions and CYP activity were evaluated."	( Critical pharmacokinetic and pharmacodynamic drug-herb interactions in rats between warfarin and pomegranate peel or guava leaves extracts. Alnaqeeb, M; Ghanim, BY; Idkaidek, N; Mallah, EM; Mansor, KA; Qinna, NA, 2019)	0.51
" This developed and validated method was successfully applied in the pharmacokinetic study of CUR, THC, QR, and PF in rats."	( Simultaneous determination of curcumin, tetrahydrocurcumin, quercetin, and paeoniflorin by UHPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. Cai, D; Gan, H; Guan, Y; Jiang, F; Lao, B; Liu, X; Wen, D; Yu, W; Zheng, J; Zhong, G, 2019)	0.76
" The aim of the current study was to characterize pharmacokinetic properties of DOPAC and 3-HPAA after intravenous bolus application in rats."	( Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats. Butterweck, V; Hamburger, M; Oufir, M; Sampath, C; Zabela, V, 2020)	0.56
"To develop and validate a sensitive and reliable ultra-high-performance liquid chromatography- tandem mass spectrometry (UHPLC-MS/MS) method for the quantitative determination of quercitrin levels in rat plasma, and test its application in a pharmacokinetic investigation after the oral administration of Polygoni cuspidati folium capsules (HC)."	( Quantitative Determination of Quercitrin Levels in Rat Plasma Using UHPLC-MS/MS and its Application in a Pharmacokinetic Study after the Oral Administration of Polygoni cuspidati Folium Capsules. Bi, XL; Feng, CT; Ma, ST; Zhang, N; Zhang, XY, 2022)	0.72
" The pharmacokinetic parameters suggested that quercitrin may be present in the peripheral tissues of rats."	( Quantitative Determination of Quercitrin Levels in Rat Plasma Using UHPLC-MS/MS and its Application in a Pharmacokinetic Study after the Oral Administration of Polygoni cuspidati Folium Capsules. Bi, XL; Feng, CT; Ma, ST; Zhang, N; Zhang, XY, 2022)	0.72
"In this study, the pharmacokinetic profiles of the bioactive components in the leaf extract of the medicinal herb, Cudrania tricuspidate, were investigated using an MS/MS-based molecular networking system."	( Molecular networking-guided strategy for the pharmacokinetic study of herbal medicines: Cudrania tricuspidata leaf extracts. Lee, EK; Park, KB; Seo, JI; Yoo, HH; Yu, JS, 2022)	0.72
" Nevertheless, no study has been performed on the exposure differences of the pharmacodynamic material basis in vivo caused by different extraction methods."	( Integrated metabolism, network pharmacology, and pharmacokinetics to explore the exposure differences of the pharmacodynamic material basis in vivo caused by different extraction methods for Saussurea involucrata. Chen, B; Liu, M; Lyu, H; Ma, C; Tu, S; Wu, C; Xu, X; Yang, L; Yiming, A, 2022)	0.72
"Based on the integrated strategy of metabolism, network pharmacology, and pharmacokinetics, we aimed to reveal exposure differences in pharmacodynamic substances caused by different extraction methods."	( Integrated metabolism, network pharmacology, and pharmacokinetics to explore the exposure differences of the pharmacodynamic material basis in vivo caused by different extraction methods for Saussurea involucrata. Chen, B; Liu, M; Lyu, H; Ma, C; Tu, S; Wu, C; Xu, X; Yang, L; Yiming, A, 2022)	0.72
" Twenty-three prototype components were analyzed by network pharmacology, and seven critical active components were selected as representative markers for the pharmacokinetic study."	( Integrated metabolism, network pharmacology, and pharmacokinetics to explore the exposure differences of the pharmacodynamic material basis in vivo caused by different extraction methods for Saussurea involucrata. Chen, B; Liu, M; Lyu, H; Ma, C; Tu, S; Wu, C; Xu, X; Yang, L; Yiming, A, 2022)	0.72
" This research aimed to provide the basis of metabolism in vivo for further studying these pharmacodynamic differences."	( Integrated metabolism, network pharmacology, and pharmacokinetics to explore the exposure differences of the pharmacodynamic material basis in vivo caused by different extraction methods for Saussurea involucrata. Chen, B; Liu, M; Lyu, H; Ma, C; Tu, S; Wu, C; Xu, X; Yang, L; Yiming, A, 2022)	0.72
" This review discusses and reviews the pharmacological activity, pharmacokinetic characteristics, and targeted delivery nanosystems of quercetin in protecting against cerebral ischemic injury, and provides information on various downstream signaling pathways regulated by quercetin, such as PI3k/Akt, MAPK, and Sirt1."	( Protective effects of dietary quercetin on cerebral ischemic injury: pharmacology, pharmacokinetics and bioavailability-enhancing nanoformulations. Fu, K; Gong, L; Li, Y; Ma, C; Peng, C; Wang, C; Xue, X; Zhang, Y; Zhou, H, 2023)	1.4
" The pharmacokinetic characteristics of Hyperoside-2-hydroxypropyl-β-cyclodextrin inclusion complex in rats were evaluated."	( Pharmacokinetic studies of hyperoside-2-hydroxypropyl-β-cyclodextrin inclusion complex and ameliorated DSS-induced colitis in mice. Cao, S; Chu, X; Ding, Y; Fu, X; Li, X; Li, Y; Liu, C; Su, J; Wang, X; Xue, J; Zhang, R; Zhang, X, 2023)	0.91

Compound-Compound Interactions

Quercetin in combination with Testosterone and Estradiol contributed to stabilization of eNOS and nNOs expression already at early observation phases, and reduced the level of iNOS expression with its further disappearance in later observation period.

Excerpt	Reference	Relevance
"The effect of acetylsalicylic acid in combination with quercetin on blood serum biochemiluminescence in the hypoxic syndrome was studied."	( [A biochemiluminescent analysis of the pharmacotherapeutic activity of acetylsalicylic acid in combination with quercetin in a hypoxic syndrome]. Luk'ianchuk, VD; Savchenkova, LV; Semenova, IA, )	0.59
"The effects of the anticancer drug irinotecan combined with ethanolic extract of propolis (EEP), a water-soluble derivate of propolis (WSDP), quercetin and naringin on the growth of Ehrlich ascites tumor (EAT) and the life span of tumor-bearing Swiss albino mice were studied."	( Enhanced antitumor activity of irinotecan combined with propolis and its polyphenolic compounds on Ehrlich ascites tumor in mice. Basic, I; Benkovic, V; Bevanda, M; Brozovic, G; Dikic, D; Horvat Knezevic, A; Knezevic, F; Orsolic, N, 2007)	0.54
"To explore the effects of quercetin and quercetin in combination with cisplatin on adhesion, migration and invasion of HeLa cells."	( [Effects of quercetin and quercetin in combination with cisplatin on adhesion, migration and invasion of HeLa cells]. Chen, XM; Luo, RY; Zhang, FL; Zhang, W, 2008)	1.03
"Adhesion, migration and invasion of HeLa cells treated with quercetin and quercetin in combination with cisplatin were measured by adhesion assay, wound healing assay, and transwell chamber method respectively."	( [Effects of quercetin and quercetin in combination with cisplatin on adhesion, migration and invasion of HeLa cells]. Chen, XM; Luo, RY; Zhang, FL; Zhang, W, 2008)	0.97
"The results showed that quercetin and quercetin in combination with cisplatin could inhibit adhesion, migration and invasion of HeLa cells."	( [Effects of quercetin and quercetin in combination with cisplatin on adhesion, migration and invasion of HeLa cells]. Chen, XM; Luo, RY; Zhang, FL; Zhang, W, 2008)	1.03
"Quercetin and quercetin in combination with cisplatin can inhibit adhesion and migration and invasion of HeLa cells."	( [Effects of quercetin and quercetin in combination with cisplatin on adhesion, migration and invasion of HeLa cells]. Chen, XM; Luo, RY; Zhang, FL; Zhang, W, 2008)	2.17
"The article presents the data about clinical course and treatment of patients with chronic nonalcoholic steatohepatitis in combination with bowel diseases."	( [Clinical and biochemical characteristics of clinical course and management of patients with chronic nonalcoholic steatohepatitis in combination with intestinal diseases]. Kharchenko, VV, )	0.13
" Quercetin also induced polynucleation in aggressive tumor cells, which was maintained in combination with doxorubicin."	( Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells. Idrizi, E; Juillerat-Jeanneret, L; Kenzaoui, BH; Staedler, D, 2011)	1.59
" Thus, we investigated whether quercetin supplementation suppresses the harmful effects of benzo[a]pyrene (BaP) alone or combined with β-carotene in the lungs of Mongolian gerbils."	( Quercetin supplementation suppresses the secretion of pro-inflammatory cytokines in the lungs of Mongolian gerbils and in A549 cells exposed to benzo[a]pyrene alone or in combination with β-carotene: in vivo and ex vivo studies. Chan, ST; Chuang, CH; Liao, JW; Liu, KL; Tseng, MJ; Yeh, CL; Yeh, SL, 2012)	2.11
" The present study was carried out to compare the effect of a novel agent glucosamine alendronate (GA) alone and is combination with dihydroquercetin (DHQ) against the effect of a known drug alendronate (ALN) in the senescence-accelerated OXYS rats as model of osteoporosis."	( Efficacy of glucosamine alendronate alone & in combination with dihydroquercetin for treatment of osteoporosis in animal model. Kolosova, NG; Muraleva, NA; Ofitserov, EN; Tikhonov, VP, 2012)	0.81
"The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions."	( Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR, 2012)	0.38
" In this study the polyphenol flavonoid quercetin (Q) or sodium butyrate (B) suppressed human esophageal 9706 cancer cell growth in dose dependent manner, and Q combined with B (Q+B) could further inhibit Eca9706 cell proliferation than that induced by Q or B alone, compared with untreated control group (C) in MTT assay."	( Aberrant epigenetic alteration in Eca9706 cells modulated by nanoliposomal quercetin combined with butyrate mediated via epigenetic-NF-κB signaling. Wang, JL; Wu, JL; Yang, SL; Zheng, NG, 2014)	0.9
" Apoptotic effects of liposomal quercetin (LQ, with cytomembrane-philia) combined with CD133 antiserum were also detected by CD133 immunocytochemistry combined with TUNEL assay."	( Anti-CSC effects in human esophageal squamous cell carcinomas and Eca109/9706 cells induced by nanoliposomal quercetin alone or combined with CD 133 antiserum. Li, JP; Mo, SJ; Wu, JL; Zheng, NG, 2014)	0.9
" In this study, leaves of Myrcia palustris were investigated by high-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR."	( High-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR: α-Glucosidase inhibitors and acetylated ellagic acid rhamnosides from Myrcia palustris DC. (Myrtaceae). Brighente, IMC; Moresco, HH; Staerk, D; Tahtah, Y; Wubshet, SG, 2015)	0.42
"With the idea that platinum compounds that bind with DNA differently than cisplatin may be better-able to overcome platinum resistance in ovarian tumor, the monofunctional platinum complex tris(imidazo(1,2-α)pyridine) chloroplatinum(II) chloride (coded as LH6) has been synthesized and investigated for its activity, alone and in combination with the phytochemicals curcumin and quercetin, against human ovarian A2780, A2780(cisR) and A2780(ZD0473R) cancer cell lines."	( Monofunctional Platinum-containing Pyridine-based Ligand Acts Synergistically in Combination with the Phytochemicals Curcumin and Quercetin in Human Ovarian Tumour Models. Arzuman, L; Beale, P; Huq, F; Yu, JQ, 2015)	0.79
"The present study was carried out to investigate the influence of dietary quercetin in combination with α-tocopherol on growth performance, antioxidant potential, lipid stability and fatty acid composition in breast meat of birds."	( Lipid stability, antioxidant potential and fatty acid composition of broilers breast meat as influenced by quercetin in combination with α-tocopherol enriched diets. Butt, MS; Shabbir, MA; Shahid, M; Sohaib, M, 2015)	0.86
"Studied oxygen independent reaction and phagocytic activity of macrophage cells of patients with chronic obstructive pulmonary disease (COPD) II-III stage when combined with coronary heart disease (CHD)."	( [EFFICIENCY OF COMBINATION OF ROFLUMILAST AND QUERCETIN FOR CORRECTION OXYGEN- INDEPENDENT MECHANISMS AND PHAGOCYTIC ACTIVITY OF MACROPHAGE CELLS OF PATIENTS WITH ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHEN COMBINED WITH CORONARY HEAR Gerych, P; Yatsyshyn, R, )	0.39
" While the drug-drug interaction potential between flavonoids and co-ingested drugs still remain an issue, opportunities exist for the combination of flavonoids with suitable anti-cancer drugs to enhance the bioavailability of anti-cancer drugs and thereby reduce the dose size of the anti-cancer drugs and improve its therapeutic index."	( Recent trends in preclinical drug-drug interaction studies of flavonoids--Review of case studies, issues and perspectives. Srinivas, NR, 2015)	0.42
"To detect the effects of quercetin (Que) combined with 2-methoxyestradiol (2-ME) on the proliferation of androgen-dependent LNCaP human prostate cancer cells line and androgen-independent PC-3 human prostate cancer cells line, and to evaluate the antitumor effects of different combos of the two drugs."	( [Effect of 2-methoxyestradiol combined with quercetin on prostate cancer in vitro]. Song, LM; Wang, GD; Wang, HP; Xing, NZ, 2016)	1
" T2DM was induced in Wistar rats by intraperitoneal administration of nicotinamide and streptozotocin and combination with high fructose diets for 8 weeks."	( Quercetin-Rich Guava (Psidium guajava) Juice in Combination with Trehalose Reduces Autophagy, Apoptosis and Pyroptosis Formation in the Kidney and Pancreas of Type II Diabetic Rats. Chen, TY; Chien, CT; Kuo, YT; Lin, CF, 2016)	1.88
" Overall, combination with chemometrics and quantitative analysis would provide a useful and simple method for quality control of FCP in the future."	( Combination with Chemometrics and Quantification for Quality Evaluation and Variety Identification of Flos Chimonanthi Praecocis by HPLC. Gu, BR; Su, JH; Sun, L; Xing, YW; Zhang, C, 2016)	0.43
"Previous research found Potentilla fruticosa leaf extracts (PFE) combined with green tea polyphenols (GTP) showed obvious synergistic effects based on chemical mechanisms."	( Synergistic effects and related bioactive mechanisms of Potentilla fruticosa Linn. leaves combined with green tea polyphenols studied with microbial test system (MTS). Ji, X; Li, DW; Liu, ZH; Luo, ZW; Wang, DM, 2018)	0.48
" The aim of our research was the synthesis of a nanocarrier of quercetin combined with temozolomide, to enhance the specificity and efficacy of this anticancer drug commonly used in glioblastoma treatment."	( Novel nanohydrogel of hyaluronic acid loaded with quercetin alone and in combination with temozolomide as new therapeutic tool, CD44 targeted based, of glioblastoma multiforme. Armenia, E; Barbarisi, A; Barbarisi, M; De Sena, G; Iaffaioli, RV; Quagliariello, V; Schiavo, L; Tafuto, S, 2018)	0.97
" Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD."	( Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences. Kumar, P; Singh, S, 2018)	1.68
" The purpose of this study was to investigate the therapeutic effect of quercetin combined with irinotecan/SN-38 in the AGS human gastric cancer cell line in vitro and in vivo."	( Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. Hou, YC; Lei, CS; Lin, MT; Pai, MH; Yeh, SL, 2018)	1.1
" Our findings showed that metformin in combination with quercetin synergistically inhibited the growth, migration and invasion of both PC-3 and LNCaP cells."	( Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway. Gong, F; Liu, P; Miao, Q; Sun, S, 2018)	1.03
" We determined the effects of SR alone or in combination with the antioxidant α-glycosyl isoquercitrin (AGIQ) on hyperlipidemia- and steatosis-related precancerous lesions in high-fat diet (HFD)-fed rats subjected to a two-stage hepatocarcinogenesis model."	( Spironolactone in Combination with α-glycosyl Isoquercitrin Prevents Steatosis-related Early Hepatocarcinogenesis in Rats through the Observed NADPH Oxidase Modulation. Eguchi, A; Hayashi, SM; Kawashima, M; Kimura, M; Koyanagi, M; Makino, E; Maronpot, RR; Mizukami, S; Murayama, H; Nagahara, R; Nakamura, M; Ohtsuka, R; Shibutani, M; Takahashi, N; Yoshida, T, 2018)	0.48
" In contrast to Spasmex, Mirabegron and Quercetin in combination with Testosterone and Estradiol contributed to stabilization of eNOS and nNOs expression already at early observation phases, and reduced the level of iNOS expression with its further disappearance in the later observation period."	( MORPHOLOGICAL ASSESSMENT OF NO-SYNTHASE DISTRIBUTION IN OVERACTIVE BLADDER AND STRESS URINE INCONTINENCE IN ANIMAL MODELS ADMINISTERED WITH EXPERIMENTAL PHARMACOCORRECTION REGIMENS. Iatsyna, O; Kostyev, F; Vernygorodskyi, S, 2018)	0.75
" Therefore, we hypothesized the improved anticancer efficacy of QUE in combination with isoenzyme inhibitors-rottlerin (ROT-PKCδ inhibitor), G0 6983 (PKCα inhibitor), and PI-103 (p110α-class I PI3K inhibitor) in MCF-7 and RAW 264."	( Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. Maurya, AK; Vinayak, M, 2019)	0.78
" The aim: The present study was designed to evaluate the indices of nitric oxide (NO) system in blood serum and a colon tissue supernatant of rats with chronic enterocolitis combined with streptozotocin-induced diabetes."	( The effect of flavonoid quercetine on the indices of nitric oxide system in rats with chronic enterocolitis combined with streptozotocin-induced diabetes. Krynytska, І; Kushynska, M; Marushchak, M; Pavlenko, I, )	0.44
" Herewith more pronounced intensification of nitroxydergic processes was observed in rats with chronic enterocolitis combined with streptozotocin-induced diabetes."	( The effect of flavonoid quercetine on the indices of nitric oxide system in rats with chronic enterocolitis combined with streptozotocin-induced diabetes. Krynytska, І; Kushynska, M; Marushchak, M; Pavlenko, I, )	0.44
" This study was carried out to investigate the effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in liver and intestine of broiler chicken."	( Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens. Mathapati, BS; Modi, CM; Patel, HB; Patel, UD, 2019)	1.06
" Therefore, the present study was designed to evaluate the neuroprotective effect of quercetin in combination with piperine against rotenone- and iron supplement-induced model of PD."	( Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement-Induced Parkinson's Disease in Experimental Rats. Raj, K; Sharma, S; Singh, S, 2020)	1.08
" To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD."	( Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise. Arteaga-Ortiz, R; Calbet, JAL; Dorado, C; Gallego-Selles, A; Galvan-Alvarez, V; Gelabert-Rebato, M; Lopez-Rios, L; Martin-Rincon, M; Martin-Rodriguez, S; Martinez-Canton, M; Morales-Alamo, D; Perez-Regalado, S; Santana, A; Wiebe, JC, 2020)	1
" In this work, we constructed a nano-system using microbubbles to promote the crossing of drugs across the BBB, where microbubbles in combination with focused ultrasound were used to mediate the transient opening of the BBB and delivery of nanomedicines."	( Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain parenchyma and relief of endoplasmic reticulum stress to treat Alzheimer's disease. Chen, X; Gong, Y; Huang, A; Liu, J; Liu, Y; Qin, X; Xie, W; Yuan, X; Zhou, H; Zhu, X, 2020)	0.79
" The synergistic scavenging effect and mechanism of curcumin combined with quercetin on ACR was analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS)."	( Trapping of Acrolein by Curcumin and the Synergistic Inhibition Effect of Curcumin Combined with Quercetin. Jiang, X; Lu, Y; Lv, H; Lv, L, 2021)	1.07
" Therefore, a drug-drug cocrystal of two antithrombotic agents with poor solubility was developed, which exhibited greatly improved solubility, bioavailability and superior stability, indicating a novel method to overcome the shortages of drug combination."	( Cocrystal of Apixaban-Quercetin: Improving Solubility and Bioavailability of Drug Combination of Two Poorly Soluble Drugs. Du, G; Jiao, L; Kong, D; Lu, Y; Song, J; Wang, H; Yang, D; Yang, H; Yang, S; Zhang, L; Zhao, X, 2021)	0.94
" These results indicated that quercetin combined with BmNPV could inhibit the activities of protective enzymes and lead to oxidative damage to silkworm."	( The effects of quercetin combined with nucleopolyhedrovirus on the growth and immune response in the silkworm (Bombyx mori). Kang, Z; Liu, H; Ren, F; Shi, G; Zhou, Y, 2021)	1.26
"In this study, the therapeutic efficacy of quercetin in combination with remdesivir and favipiravir, were evaluated in severe hospitalized COVID-19 patients."	( The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial. Abolnezhadian, F; Alavi, SM; Ghafourian, M; Khodadadi, A; Mahmoudian-Sani, MR; Nashibi, R; Sharhani, A; Shohan, M, 2022)	1.28
"To study the therapeutic effect of lycopene combined with quercetin and curcumin on chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS) in rats and its underlying mechanism."	( [Lycopene combined with quercetin and curcumin for chronic prostatitis/chronic pelvic pain syndrome in rats: Effect and mechanism]. Chen, D; Xing, NZ; Yang, FY; Zhao, QX, 2021)	1.17
" Conclusions: Lycopene combined with quercetin and curcumin is more effective than any of the three drugs used alone in the treatment of CP/CPPS, which may be associated with its alleviation of inflammatory response and oxidative stress by interaction between the NF-κB, MAPKs and Nrf2 signaling pathways."	( [Lycopene combined with quercetin and curcumin for chronic prostatitis/chronic pelvic pain syndrome in rats: Effect and mechanism]. Chen, D; Xing, NZ; Yang, FY; Zhao, QX, 2021)	1.2
" The aim of this study is identifying its possible therapeutic targets and to evaluate the effects of AM in combination with a PARP inhibitor (olaparib) in the treatment of BRCA wild-type ovarian cancer."	( Anticancer Effect of Active Component of Astragalus Membranaceus Combined with Olaparib on Ovarian Cancer Predicted by Network-Based Pharmacology. Guo, Z; Jiang, J; Lang, F; Li, J; Liu, Y, 2023)	0.91
" A collagenase I-induced ICH mice model was established and randomly separated into the model group (Model), quercetin gavage group (Quercetin), MSCs transplantation group (MSCs), and MSCs transplantation combined with IronQ group (MSCs + IronQ) after 24 h."	( Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/syk signaling pathway. Bai, X; Dechsupa, N; Huang, B; Kantapan, J; Mazhar, M; Wang, H; Wang, L; Yang, G; Yang, S; Zou, Y, 2023)	1.12
"In this study, cultured MCF7 and MDA-MB-231 cells were treated with different concentrations of quercetin/fisetin individually and in combination with naringenin."	( Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines. Jalalpour Choupanan, M; Reiisi, S; Shahbazi, S, 2023)	1.41
"Our results indicate that quercetin/fisetin enhances the anti-proliferative and anti-migratory activities in combination with naringenin in MCF7 and MDA-MB-231 human breast cancer cell lines."	( Naringenin in combination with quercetin/fisetin shows synergistic anti-proliferative and migration reduction effects in breast cancer cell lines. Jalalpour Choupanan, M; Reiisi, S; Shahbazi, S, 2023)	1.5
" The present study employed network pharmacology and molecular docking to determine the mechanism of action and the key active components of BYHWD of Tetrandrine in combination with BYHWD for silicosis."	( Unraveling the mechanism of tetrandrine combined with Buyang Huanwu Decoction against silicosis using network pharmacology and molecular docking analyses. He, S; Jiang, H; Li, Y; Lyu, Z; Zhao, Y, 2023)	0.91
"Gleditsiae sinensis fructus Pills (GF) is a famous classical prescription, that is regularly combined with Jujubae fructus (JF) for the treatment of chronic bronchitis (CB) in the clinic."	( Gleditsiae sinensis fructus Pills combined with Jujubae fructus attenuate chronic bronchitis via regulation of AGE-RAGE signaling pathway. Kang, L; Li, HW; Li, K; Peng, X; Wang, CC; Zhou, N; Zuo, BL, 2024)	1.44
"To elucidate the mechanisms of action of Gleditsiae sinensis fructus Pills combined with Jujubae fructus (GF&JF) against CB based on network pharmacology and experimental verification."	( Gleditsiae sinensis fructus Pills combined with Jujubae fructus attenuate chronic bronchitis via regulation of AGE-RAGE signaling pathway. Kang, L; Li, HW; Li, K; Peng, X; Wang, CC; Zhou, N; Zuo, BL, 2024)	1.44

Bioavailability

Quercetin (Q) has low bioavailability due to poor water solubility, low absorption, and rapid excretion from the body. After oral administration of TFH-PC in rats, the bioavailability of isorhamnetin, kaempferol, and quercetins was 223%, 172%, and 242% respectively.

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51
" bioavailability of the dihydropyridine calcium antagonists nifedipine and felodipine."	( Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. Edgar, B; Eriksson, UG; Lundahl, J; Miniscalco, A; Regårdh, CG, 1992)	0.28
"We studied the bioavailability and the plasma transport of flavonols in rats fed quercetin or rutin diets."	( Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. Agullo, G; Demigné, C; Favier, ML; Manach, C; Morand, C; Régérat, F; Rémésy, C; Texier, O, 1995)	1.96
"1 microgram/ml, suggesting that the negative in vivo results may have been due to limited bioavailability of the compound."	( Genotoxicity studies of quercetin and shikimate in vivo in the bone marrow of mice and gastric mucosal cells of rats. Jones, RS; Ngomuo, AJ, 1996)	0.6
" However, flavonoids are poorly absorbed from the gut and are subject to degradation by intestinal micro-organisms."	( Review of the biology of Quercetin and related bioflavonoids. Formica, JV; Regelson, W, 1995)	0.59
" The relative bioavailability of quercetin from apples and rutinoside was one-third of that from onions."	( Bioavailability of the dietary antioxidant flavonol quercetin in man. de Vries, JH; Hollman, PC; Katan, MB; Mengelers, MJ; van Trijp, JM, 1997)	0.83
" Bioavailability of quercetin from apples and of pure quercetin rutinoside was both 30% relative to onions."	( Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. Buysman, MN; de Vries, JH; Hollman, PC; Katan, MB; Mengelers, MJ; van der Gaag, MS; van Trijp, JM, 1997)	0.87
" However, there is limited knowledge on the oral bioavailability of these natural products."	( Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells. Walgren, RA; Walle, T; Walle, UK, 1998)	0.67
"The bioavailability in human subjects of non-nutrient plant factors, including dietary flavonoids and phyto-oestrogens, is of great importance relative to their reported health protective effects."	( The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens. Wiseman, H, 1999)	0.3
" However, in-vivo-data on absorption, bioavailability and metabolism after oral intake are scarce and contradictory."	( Urinary metabolites of flavonoids and hydroxycinnamic acids in humans after application of a crude extract from Equisetum arvense. Graefe, EU; Veit, M, 1999)	0.3
" The bioavailability of the rutinoside was only 20% of that of the glucoside."	( The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Bijsman, MN; Cnossen, EP; de Vries, JH; Hollman, PC; Katan, MB; van Gameren, Y, 1999)	0.3
" It is essential to know the bioavailability of flavonoids involving intestinal absorption, metabolic conversion and urinary excretion, in order to evaluate their in vivo antioxidant activity after intake."	( Dietary flavonoids as antioxidants in vivo: conjugated metabolites of (-)-epicatechin and quercetin participate in antioxidative defense in blood plasma. Terao, J, 1999)	0.52
"Diet-mediated induction of intestinal UGT may be important for the bioavailability of carcinogens and other toxic chemicals as well as therapeutic drugs."	( Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Galijatovic, A; Walle, T; Walle, UK, 2000)	0.54
" The sugar moiety in quercetin glycosides affects their bioavailability in humans."	( Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans. Hollman, PC; Katan, MB; Olthof, MR; Vree, TB, 2000)	0.94
" In the present study, we have investigated the bioavailability of the flavonol quercetin after intravenous and oral application in pigs equipped with a permanent jugular catheter."	( Bioavailability and metabolism of the flavonol quercetin in the pig. Ader, P; Wessmann, A; Wolffram, S, 2000)	0.79
" It is present in the diet, and the hepatic and duodenal sulphation might limit the bioavailability of this compound."	( Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. De Santi, C; Mosca, F; Pacifici, GM; Pietrabissa, A; Spisni, R, 2000)	0.31
" However, the bioavailability of these compounds is questionable."	( Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption. Otake, Y; Walle, T; Walle, UK; Wilson, FA, 2000)	1.75
" Resveratrol is sulphated, and the hepatic and duodenal sulphation might limit the bioavailability of this compound."	( Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. De Santi, C; Mosca, F; Pacifici, GM; Pietrabissa, A; Spisni, R, 2000)	0.31
"In clinical trials, studying the effects of quercetin from rutin, bioavailability must be taken into consideration and plasma quercetin concentrations monitored."	( Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Alfthan, G; Aro, A; Erlund, I; Kenraali, J; Kosonen, T; Mäenpää, J; Parantainen, J; Perttunen, K, 2000)	0.89
" Glucuronidation may reduce the bioavailability of this compound however, flavonoids inhibit resveratrol glucuronidation and such an inhibition might improve the bioavailability of resveratrol."	( Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. de Santi, C; Mosca, F; Pacifici, GM; Pietrabissa, A, 2000)	0.31
" However, data on the bioavailability of flavonols from wine are lacking."	( Red wine is a poor source of bioavailable flavonols in men. de Vries, JH; Hollman, PC; Katan, MB; Olthof, MR; van Amersfoort, I, 2001)	0.31
" We conclude that flavonols are absorbed from tea and that their bioavailability is not affected by addition of milk."	( Addition of milk does not affect the absorption of flavonols from tea in man. Hollman, PC; Katan, MB; Tijburg, LB; Van Het Hof, KH, 2001)	0.31
" However, data on the bioavailability of quercetin after oral intake are scarce and contradictory."	( Pharmacokinetics and bioavailability of quercetin glycosides in humans. Derendorf, H; Drewelow, B; Graefe, EU; Jacobasch, G; Mueller, S; Pforte, H; Riethling, AK; Uehleke, B; Veit, M; Wittig, J, 2001)	0.84
"The grapefruit juice component bergamottin is known to inactivate cytochrome P450 3A4, with grapefruit juice consumption causing increased absorption and enhanced oral bioavailability of many cytochrome P450 3A4 substrates."	( Inhibition of P-glycoprotein transport function by grapefruit juice psoralen. Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ, 2001)	0.31
" Inhibition of P-gp by citrus psoralens could present ways both to enhance bioavailability of therapies without increasing the dose and to diminish drug resistance in refractory cells."	( Inhibition of P-glycoprotein transport function by grapefruit juice psoralen. Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ, 2001)	0.31
"-) generation, thus the bioavailability of (*)NO was increased."	( A flavonoid-rich diet increases nitric oxide production in rat aorta. Benito, S; Buxaderas, S; Lopez, D; Mitjavila, MT; Puig-Parellada, P; Sáiz, MP; Sánchez, J, 2002)	0.31
" On the length basis, the absorption rate of quercetin was colon > ileum > duodenum > jejunum."	( [Study on the absorption of quercetin and rutin at different segments of intestine]. Guo, C; Su, J; Wei, J; Yang, J, 2002)	0.87
" This in vitro study allowed selection of compounds which are able to increase the moxidectin bioavailability in lambs."	( Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin. Alvinerie, M; Dupuy, J; Larrieu, G; Lespine, A; Sutra, JF, 2003)	0.55
" On the other hand, quercetin presented only as glucuronides and sulfates in the blood, indicating negligible bioavailability of quercetin, and the metabolites showed linear pharmacokinetics at the two doses studied."	( Profound difference in pharmacokinetics between morin and its isomer quercetin in rats. Chao, PD; Ho, HJ; Hou, YC; Hsiu, SL; Wen, CC, 2003)	0.88
" Both compounds increased the oral bioavailability of hypericin by ca."	( Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats. Butterweck, V; Liefländer-Wulf, U; Nahrstedt, A; Winterhoff, H, 2003)	0.32
" However, adequate intakes and absorption rate of phenolic compounds are necessary for these beneficial effects."	( Influence of cooking process on phenolic marker compounds of vegetables. Andlauer, W; Fürst, P; Hubert, M; Rings, A; Stumpf, C, 2003)	0.32
" Urinary excretions of major phenols were measured to affirm bioavailability of dietary phenols."	( Effects of phenol-depleted and phenol-rich diets on blood markers of oxidative stress, and urinary excretion of quercetin and kaempferol in healthy volunteers. Kim, HY; Kim, OH; Sung, MK, 2003)	0.53
" The bioavailability of quercetin glycosides should be clarified, because dietary quercetin is mostly present as its glycoside form."	( Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Murota, K; Terao, J, 2003)	0.93
"Recent investigations suggest that the bioavailability of quercetin depends on the glycoside moiety of the quercetin glycosides present in the diet."	( The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors. Cermak, R; Landgraf, S; Wolffram, S, 2003)	0.87
" However, the absolute water insolubility of quercetin is a key step that may limit its bioavailability and, thus, its 'in vivo' employment as a photoprotective agent."	( 'In vitro' antioxidant and photoprotective properties and interaction with model membranes of three new quercetin esters. Bonina, FP; Castelli, F; Messina, C; Nicolosi, G; Pellegrino, ML; Rocco, C; Saija, A; Tita, B; Tomaino, A; Trombetta, D, 2003)	0.79
" The results showed the elimination rate constant k and the absorption rate constant ka of quercetin were slightly more than that of kaempferol; and the absorption half-life (t(1/2a)), the elimination half-life (t(1/2)) and t(max) of quercetin were less than that of kaempferol, the differences were, however, not statistically significant."	( Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets. Wang, FM; Yao, TW; Zeng, S, )	0.7
" These results indicate that co-ingested lipids and emulsifiers could enhance the bioavailability of quercetin glucosides in onion."	( Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats. Azuma, K; Horie, H; Ippoushi, K; Ito, H; Terao, J, 2003)	0.77
" These results, indicating a flow of quercetin from albumin to haemoglobin, and vice versa, are therefore consistent with the possibility that human RBC play a pivotal role in the distribution and bioavailability of circulating flavonoids."	( Human red blood cells as a natural flavonoid reservoir. Accorsi, A; Cantoni, O; Fiorani, M, 2003)	0.59
"The present study investigates the bioavailability of resveratrol and quercetin in humans, mice, and rats after oral ingestion of grape juice preparations or pure aglycones."	( Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. Lee, MJ; Lu, H; Maliakal, P; Meng, X; Yang, CS, 2004)	0.82
"The aim of this study was to investigate the effect of quercetin on the bioavailability of paclitaxel after the oral administration of paclitaxel or a prodrug to rats pretreated with quercetin."	( Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin. Choi, JS; Jo, BW; Kim, YC, 2004)	0.78
" In this study, the influence of dietary fat on oral bioavailability of quercetin was investigated."	( Bioavailability of quercetin in pigs is influenced by the dietary fat content. Cermak, R; Lesser, S; Wolffram, S, 2004)	0.88
" The poor bioavailability of important dietary quercetin glycosides has implications for their in vivo bioactivities."	( The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Arts, IC; Faassen-Peters, M; Hollman, PC; Sesink, AL, 2004)	0.79
" However, there is limited knowledge on the bioavailability of specific phytochemicals from whole fruits and vegetables."	( Uptake of quercetin and quercetin 3-glucoside from whole onion and apple peel extracts by Caco-2 cell monolayers. Boyer, J; Brown, D; Liu, RH, 2004)	0.73
" More in-depth studies on bioavailability should facilitate correlation of mechanisms determined in vitro with in vivo situations, increase our understanding of dose-response relationships, and facilitate extrapolation of results from animal studies to human situations."	( Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Hong, J; Lambert, JD; Liao, J; Yang, CS; Yang, GY, 2005)	0.33
" These compounds have a wide range of potential health benefits, and understanding the bioavailability of flavonoids from foods is becoming increasingly important."	( In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. Boyer, J; Brown, D; Liu, RH, 2005)	0.57
" Despite the loss of quercetin from the digested shallot, the bioavailability of quercetin aglycone to the Caco-2 cells was the same in both the digested and non-digested shallot."	( In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. Boyer, J; Brown, D; Liu, RH, 2005)	0.89
"The increase in quercetin uptake following treatment with lactase suggests that dietary supplementation with lactase may increase quercetin bioavailability in lactose intolerant humans."	( In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. Boyer, J; Brown, D; Liu, RH, 2005)	0.92
" Flavonol-albumin binding is expected to modulate the bioavailability of flavonols."	( Flavonoid-serum albumin complexation: determination of binding constants and binding sites by fluorescence spectroscopy. Dangles, O; Dufour, C, 2005)	0.33
"The objective of these two open phase I clinical trials was the investigation of the bioavailability of five constituents from a hypericum extract containing tablet, which are discussed as the components contributing to the antidepressant action."	( Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. Bässler, D; Schulz, HU; Schürer, M; Weiser, D, 2005)	0.55
" Being sparingly soluble and chemically unstable in aqueous intestinal fluids, quercetin is poorly absorbed orally."	( Physicochemical and structural characterization of quercetin-beta-cyclodextrin complexes. Chow, AH; Chow, MS; Haworth, IS; Zheng, Y; Zuo, Z, 2005)	0.81
"The aim of this study was to investigate the effect of quercetin on the bioavailability of diltiazem after administering diltiazem (15 mg/kg) orally to rabbits either co-administered or pretreated with quercetin (2, 10, 20 mg/kg)."	( Enhanced diltiazem bioavailability after oral administration of diltiazem with quercetin to rabbits. Choi, JS; Li, X, 2005)	0.8
" Great differences emerge as far as ingested doses, bioavailability and liver ability to accumulate the various compounds."	( Dietary antioxidant compounds and liver health. Caporaso, N; Fogliano, V; Morisco, F; Vitaglione, P, 2004)	0.32
" The P-gp type efflux pump might limit the bioavailability of Ginkgo flavonols."	( Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin. Cao, J; Wang, Y; Zeng, S, 2005)	0.55
" The aim of the present study was to bring data on the bioavailability of quercetin and catechin when administered simultaneously."	( Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism. Manach, C; Morand, C; Remesy, C; Scalbert, A; Silberberg, M, 2005)	0.88
" However, the actual bioavailability of these compounds in vivo, especially in the prevalent glycosidic form, remains a controversial point in making an assessment of their biological importance."	( Absorption of quercetin and rutin in rat small intestine. Carbonaro, M; Grant, G, )	0.49
"The bioavailability of quercetin and rutin (quercetin-3-rutinoside) was assessed in vivo, with single-meal experiments with rats and by an in vitro method with ligated loops of rat small intestine."	( Absorption of quercetin and rutin in rat small intestine. Carbonaro, M; Grant, G, )	0.8
" An early protective action by dietary antioxidants in the gastro-intestinal tract is plausible, especially for poorly bioavailable antioxidants such as polyphenols."	( Inhibition of the metmyoglobin-induced peroxidation of linoleic acid by dietary antioxidants: Action in the aqueous vs. lipid phase. Caris-Veyrat, C; Dangles, O; Goupy, P; Vulcain, E, 2005)	0.33
" Factors that influence the bioavailability of this group of polyphenolic compounds are therefore important."	( Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro. Bennett, R; Dragoni, S; Gee, J; Sgaragli, G; Valoti, M, 2006)	0.63
" This study investigated the effect of quercetin, a dual inhibitor of CYP3A4 and P-gp, on the bioavailability and pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, in rats."	( Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats. Choi, JS; Li, X; Shin, SC, 2006)	0.83
" All phytochemicals tend to increase the therapeutic effect by blocking one or more targets of the signal transduction pathway, by increasing the bioavailability of the other drug or, by stabilizing the other drug in the system."	( Potential synergism of natural products in the treatment of cancer. Doble, M; HemaIswarya, S, 2006)	0.33
"Our data indicated that pegylated liposomal quercetin can significantly improve the solubility and bioavailability of quercetin and can be a potential application in the treatment of tumor."	( Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Chen, LJ; Diao, P; Du, XB; Fan, LY; Tang, MH; Wang, GQ; Wang, R; Wei, YQ; Wu, HB; Yang, GL; Yang, HS; Yao, WX; Ye, B; Yuan, ZP; Zhang, W; Zhao, QM; Zhao, X, 2006)	1
" Our previous study reported that quercetin significantly decreased the bioavailability of cyclosporin, a substrate for CYP3A4 and Pgp, in rats and pigs."	( Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats. Chao, PD; Hou, YC; Hsiu, SL; Tsai, SY; Wen, KC; Yang, CY, 2006)	0.61
" In this article, the results of three intervention studies investigating the bioavailability of quercetin from berries are reviewed."	( Bioavailability of quercetin from berries and the diet. Alfthan, G; Erlund, I; Freese, R; Hakala, P; Marniemi, J, 2006)	0.88
" The bioavailability of RGJ polyphenols was assessed in healthy subjects."	( Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Castilla, P; Cerrato, F; Dávalos, A; Echarri, R; Gómez-Coronado, D; Lasunción, MA; Lucas, MF; Ortega, H; Ortuño, J; Teruel, JL, 2006)	0.33
" The bioavailability of flavonoids is influenced by the metabolism of the microflora in the intestine."	( Metabolism of quercetin and rutin by the pig caecal microflora prepared by freeze-preservation. Hein, EM; Humpf, HU; Keppler, K, 2006)	0.69
"It is essential to have a thorough knowledge of the bioavailability and metabolism of dietary flavonols to understand their role in disease prevention."	( Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Crozier, A; Edwards, CA; Mullen, W, 2006)	0.55
" Flavonols at two dosages in oatmeal porridge were rapidly absorbed, and a relatively small amount of sea buckthorn oil added to the porridge seemed to have increased the bioavailability of sea buckthorn flavonols consumed at the higher dose."	( Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. Ahotupa, M; Kallio, H; Suomela, JP; Vasankari, T; Yang, B, 2006)	0.33
"We have shown recently that dietary fat content influences the bioavailability of the flavonol quercetin."	( The fatty acid pattern of dietary fat influences the oral bioavailability of the flavonol quercetin in pigs. Cermak, R; Lesser, S; Wolffram, S, 2006)	0.77
" Such processing techniques may have an impact on the flavonoid structure, resulting in changes of the bioavailability and activity of the flavonoids."	( Thermal degradation of onion quercetin glucosides under roasting conditions. Buchner, N; Driemel, G; Kroh, LW; Rauser, M; Rohn, S, 2007)	0.63
"The elaboration of novel techniques for flavonoid intracellular tracing would elucidate the compounds' absorption and bioavailability and assist molecular and pharmacological approaches, as they are promising candidates for drug development."	( Quercetin exhibits a specific fluorescence in cellular milieu: a valuable tool for the study of its intracellular distribution. Castagnino, C; Castanas, E; Katerinopoulos, HE; Munier, S; Nifli, AP; Roussakis, E; Theodoropoulos, PA; Vercauteren, J, 2007)	1.78
" The advantages of TFH SLNs are the improved oral bioavailability of TFH and the prolonged mean retention time and drug release time."	( Preparation and characterization of solid lipid nanoparticles loaded with total flavones of Hippophae rhamnoides (TFH). Cuia, F; Li, X; Wang, D; Zhao, P, )	0.13
" Such disparity may reflect an inability of semiquantitative assessment to consider how infusion time and addition of milk affect the bioavailability of potentially beneficial antioxidant polyphenols."	( Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea. Duthie, GG; Kyle, JA; McNeill, G; Morrice, PC, 2007)	0.34
" From the present study, it can be concluded that quercetin administration to diabetic rats restores vascular function, probably through enhancement in the bioavailability of endothelium-derived nitric oxide coupled to reduced blood glucose level and oxidative stress."	( Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas. Achike, FI; Machha, A; Mustafa, AM; Mustafa, MR, 2007)	2.04
" We now report the use of quercetin-hamster serum albumin combination to increase the bioavailability of quercetin."	( Albumin-quercetin combination offers a therapeutic advantage in the prevention of reduced survival of erythrocytes in visceral leishmaniasis. Biswas, D; Biswas, T; Ray, M; Sen, G, )	0.87
" In conclusion, various beverages, especially teas, inhibit the function of SULT1A3, and therefore may have the potential to increase the bioavailability of orally administered substrates of SULT1A3, such as beta(2) agonists."	( Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. Hiratsuka, A; Nishimuta, H; Ogura, K; Ohtani, H; Sawada, Y; Tsujimoto, M, 2007)	0.34
" Our objective was to determine the effect of quercetin and (-)-epigallocatechin-3-gallate (EGCG), major flavonoids present in the diet, on the PK and bioavailability of biochanin A, a flavonoid with chemopreventive properties."	( Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Moon, YJ; Morris, ME, )	0.62
" Pectin might thus enhance the bioavailability of quercetin from rutin by altering the metabolic activity of the intestinal flora and/or gut physiological function."	( Effect of pectin enhancement on plasma quercetin and fecal flora in rutin-supplemented mice. Hirayama, K; Itoh, K; Nakagawa, H; Tamura, M; Tsushida, T, 2007)	0.86
" However, the bioavailability of quercetin depends on the food source and type of glycosidic moiety linked to the molecule."	( Influence of dietary quercetin on glutathione redox status in mice. Meyers, KJ; Mitchell, AE; Rudolf, JL, 2008)	0.95
" Our data provide a new insight into the bioavailability of dietary flavonoids and the mechanism for the prevention of cardiovascular diseases."	( Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. Kanayama, M; Kawai, Y; Kobayashi, M; Murota, K; Nishikawa, T; Saito, S; Shiba, Y; Shibata, N; Terao, J; Uchida, K, 2008)	0.65
" We focused on quercetin (3,3',4',5,7- pentahydroxyflavone), a major flavonoid in onion, and its anti-atherosclerotic effect was examined from the aspect of the bioavailability and translocation to the target site."	( Vegetable flavonoids and cardiovascular disease. Kawai, Y; Murota, K; Terao, J, 2008)	0.7
"As the bioavailability of flavonoids is influenced by intestinal metabolism, we have investigated the microbial deconjugation and degradation of several flavonols and flavonol glycosides using the pig cecum in vitro model system developed in our group."	( Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by Fluorescence in situ hybridization (FISH). Friedrich, AW; Hein, EM; Humpf, HU; Rose, K; van't Slot, G, 2008)	0.35
" Hence, it was speculated that quercetin may influence the bioavailability of pioglitazone, which could be particularly crucial, as any increment in its plasma levels may raise safety concerns."	( Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibition. Bansod, KU; Dixit, PV; Kumar, V; Umathe, SN; Wanjari, MM, 2008)	2.07
" Assuming that low bioavailability of quercetin aglycone provided to humans as a pure substance is the result of its low solubility in the digestive tract, we studied its bioavailability from dietary sources in which quercetin was dispersed in the food matrix."	( Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides. Bucinski, A; Honke, J; Piskula, MK; Romaszko, J; Szawara-Nowak, D; Wiczkowski, W; Zielinski, H, 2008)	2.06
" The absolute bioavailability (F) of irinotecan control was 33%, which was increased to 43% (1."	( Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein. Awasthi, A; Bansal, T; Jaggi, M; Khar, RK; Talegaonkar, S, 2008)	0.56
"Although the flavonol quercetin is intensively investigated, our knowledge about its bioavailability and possible target organs is far from being complete."	( Tissue distribution of quercetin in pigs after long-term dietary supplementation. Bieger, J; Blank, R; Cermak, R; de Boer, VC; Hollman, PC; Kamphues, J; Wolffram, S, 2008)	0.97
" It is concluded that quercetin increases the bioavailability of the pro-carcinogen PhIP in rats pointing at a potential adverse effect of this supposed beneficial food ingredient."	( Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats. Alink, GM; Freidig, AP; Groten, JP; Rietjens, IM; Schutte, ME; Spenkelink, B; Vaessen, JC; van de Sandt, JJ, 2008)	2.1
" We have analyzed the vasorelaxant effects and the role on NO bioavailability and endothelial function of quercetin and its conjugated metabolites (quercetin-3-glucuronide, isorhamnetin-3-glucuronide and quercetin-3'-sulfate) in rat aorta."	( Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. Cogolludo, A; Duarte, J; Gonzalez-Paramas, A; Hughes, DA; Jimenez, R; Kroon, PA; Lodi, F; Lopez-Sepulveda, R; Moreno, L; Needs, PW; Perez-Vizcaino, F; Santos-Buelga, C, 2009)	0.81
"Quercetin bioavailability has been underestimated in the past and can be improved by food matrix components or particular delivery forms."	( Quercetin: potentials in the prevention and therapy of disease. Bischoff, SC, 2008)	3.23
" The relative bioavailability of QT-SLNs to quercetin suspension was 571."	( Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. Li, H; Li, L; Lou, H; Ma, Y; Zhai, G; Zhao, X, 2009)	0.87
"85 h) show that oral bioavailability is improved evidently compared with that of quercetin."	( Preparation and prodrug studies of quercetin pentabenzensulfonate. Deng, Z; Peng, Y; Wang, C, 2008)	0.85
" The study reveals that as it passes through the gastrointestinal tract, almost all of the of [2-(14)C]quercetin-4'-glucoside is converted to phenolic acids, compounds not monitored in previous flavonol bioavailability studies with model animal systems, some of which have used exceedingly high doses of the aglycone quercetin (500 mg/kg body weight), which is not a normal dietary component."	( Bioavailability of [2-(14)C]quercetin-4'-glucoside in rats. Auger, C; Caldwell, ST; Crozier, A; Edwards, CA; Hartley, RC; Lean, ME; Mullen, W; Rouanet, JM; Teissèdre, PL, 2008)	0.85
"The use of a high quercetin dose to demonstrate its absorption and bioavailability does not reflect the real dietary situation because quercetin glycosides are usually present in small amounts in the human diet."	( Phenylacetic acids were detected in the plasma and urine of rats administered with low-dose mulberry leaf extract. Cheng, HM; Lee, CY; Sim, SM, 2008)	0.68
" The absolute bioavailability of taxifolin after oral administration of lipid solution was 36%."	( Determination and pharmacokinetic study of taxifolin in rabbit plasma by high-performance liquid chromatography. Karlina, MV; Kosman, VM; Makarov, VG; Makarova, MN; Pozharitskaya, ON; Shikov, AN, 2009)	0.35
" It was concluded that suppression of degrading quercetin aglycone in the large intestine has a major role for increasing alpha G-rutin bioavailability by DFA III and FOS feedings."	( Oligosaccharide promotes bioavailability of a water-soluble flavonoid glycoside, alpha G-rutin, in rats. Chiji, H; Hara, H; Matsukawa, N; Matsumoto, M, 2009)	0.61
"The bioavailability of polyphenols in human and rodents has been discussed regarding their biological activity."	( Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods. Ishisaka, A; Kawai, Y; Murota, K; Nishikawa, T; Saito, S; Terao, J, 2009)	0.67
"The effect of apple pectin (AP) on quercetin and rutin bioavailability was investigated."	( Chronic ingestion of apple pectin can enhance the absorption of quercetin. Iwai, K; Matsue, H; Nishijima, T; Saito, Y; Takida, Y, 2009)	0.87
"01) increased the absolute bioavailability (AB) of etoposide to 12."	( Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats. Choi, JS; Li, X, 2009)	0.74
"The dietary bioavailability of the isoflavone genistein is decreased in older rats compared to young adults."	( The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes. Blumberg, JB; Bolling, BW; Chen, CY; Court, MH, 2010)	0.62
" These results indicated that P-glycoprotein and Multidrug Resistance Protein 2 might play important roles in limiting the bioavailability of those compounds."	( Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp. Gao, LB; Liu, T; Meng, MX; Wang, XD; Xu, Q; Zeng, S, 2009)	0.35
"Epigallocatechin gallate (EGCG), a main anticancer component in green tea, has a poor bioavailability in rats and humans due to oxidation, metabolism and its efflux."	( Studies on the effects of oral administration of nutrient mixture, quercetin and red onions on the bioavailability of epigallocatechin gallate from green tea extract. Gawande, S; Ivanov, V; Kale, A; Kotwal, S; Netke, S; Niedzwiecki, A; Rath, M; Roomi, W, 2010)	0.6
" The data suggest that quercetin acts as a protective agent in mouse corpus cavernosum, increasing the bioavailability of exogenous nitric oxide by protecting it from superoxide anion (O(2)(-))."	( Protective effect of quercetin, a polyphenolic compound, on mouse corpus cavernosum. Ertuğ, PU; Oğülener, N; Olguner, AA; Singirik, E, 2010)	0.99
" In vivo, these effects could result in reduced activation of procarcinogens and/or in drug bioavailability limitation."	( CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells. Dupont, I; Larondelle, Y; Pussemier, L; Schneider, YJ; Scippo, ML; Sergent, T; Van der Heiden, E, 2009)	0.35
"Quercetin has been shown to possess beneficial pharmacological properties in treatment of heart disease, but lack of stability and bioavailability limits its clinical use."	( 3,3',4',5,7-Pentamethylquercetin reduces angiotensin II-induced cardiac hypertrophy and apoptosis in rats. Du, X; Liang, Y; Mao, Z; Sun, Z, 2009)	2.11
" We conclude that chronic ingestion of high doses of the flavonol quercetin will decrease the bioavailability of simvastatin to a significant extent."	( Effects of the flavonol quercetin on the bioavailability of simvastatin in pigs. Cermak, R; Langguth, P; Wein, S; Wolffram, S, 2009)	0.9
"Contribution of intestinal bacterial degradation of quercetin aglycone to the promotive effects of fructooligosaccharides and di-D-fructose anhydride III (DFAIII) on quercetin-3-O-beta-glucoside (Q3G) bioavailability was examined."	( Nondigestible saccharides suppress the bacterial degradation of quercetin aglycone in the large intestine and enhance the bioavailability of quercetin glucoside in rats. Hagio, M; Hara, H; Inoue, R; Matsukawa, N; Matsumoto, M; Shinoki, A, 2009)	0.84
" These results demonstrate the feasibility of developing a diet-based combinatorial approach for CaP prevention and treatment and raise the possibility that serum added to culture medium might affect uptake, bioavailability and biological efficacy of dietary phytochemicals."	( Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin. Hsieh, TC; Wu, JM, 2009)	0.56
"Quercetin is a plant-derived flavonoid widely known by its anti-oxidant and anti-inflammatory properties, but its oral bioavailability is very poor and this becomes difficult to assess its therapeutic potential."	( Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Andrade, EL; Calixto, JB; Chaves, JS; Dora, CL; Lemos-Senna, E; Rogerio, AP; Silva, LF, 2010)	2.1
" However, their bioavailability and, in particular, their intestinal absorption mechanism have not yet been clearly identified."	( Quercetin and naringenin transport across human intestinal Caco-2 cells. Al Ahmad, A; Muller, CD; Nait Chabane, M; Peluso, J; Ubeaud, G, 2009)	1.8
"In our experimental conditions, quercetin and naringenin were poorly absorbed by Caco-2 cells."	( Quercetin and naringenin transport across human intestinal Caco-2 cells. Al Ahmad, A; Muller, CD; Nait Chabane, M; Peluso, J; Ubeaud, G, 2009)	2.08
" However, low oral bioavailability of quercetin due to insolubility in water has limited its use as a food additive or dietary supplement."	( Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats. Kanemaru, M; Makino, T; Mizukami, H; Moriwaki, M; Shimizu, R; Suzuki, Y, 2009)	0.87
"The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated."	( Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet. Bredsdorff, L; Haraldsdóttir, J; Knuthsen, P; Krogholm, KS; Rasmussen, SE, 2010)	0.86
" The relative bioavailability of DHQ after the administration of Flamena D amounted to 159% in comparison to that of the parent substance of DHQ."	( [Comparative pharmacokinetics of dihydroquercetin in rats upon peroral administration of a parent compound and liposomal flamen D]. Gekkiev, BI; Gorlov, VV; Grigor'ev, AM; Kolyvanov, GB; Litvin, AA; Sariev, AK; Viglinskaia, AO; Zherdev, VP, 2010)	0.63
"Although the flavonol quercetin is used as a supplement in commercial dog food, data on quercetin bioavailability in dogs are not available."	( Oral bioavailability of quercetin from different quercetin glycosides in dogs. Abraham, G; Cermak, R; Reinboth, M; Ungemach, FR; Wolffram, S, 2010)	0.98
" Co-effectors in the extract improve the bioavailability of active constituents such as hypericin (1) (pharmacokinetic synergy)."	( Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular). Butterweck, V; Nahrstedt, A, 2010)	0.36
" These results demonstrate that quercetin-mediated stimulation of eNOS phosphorylation increases NO bioavailability in endothelial cells and can thus play a role in the vascular protective effects associated with improved endothelial cell function."	( Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels. Constance, C; Inoue, T; Khoo, NK; Parks, DA; Patel, RP; Pozzo-Miller, L; White, CR; Zhou, F, 2010)	0.98
" Our data show that the regiospecific glucosylation of flavonoids by the quercetin 5-O-glucosyltransferase can greatly affect the overall bioavailability of flavonoids in animals."	( The silkworm Green b locus encodes a quercetin 5-O-glucosyltransferase that produces green cocoons with UV-shielding properties. Daimon, T; Hirayama, C; Kanai, M; Katsuma, S; Kosegawa, E; Meng, Y; Nakamura, M; Ruike, Y; Shimada, T; Tsujimoto, G, 2010)	0.87
" Recently, the clinical use of temozolomide (TMZ) has become the more commonly used analog of DTIC-related oral agents because of its greater bioavailability and ability to cross the blood brain barrier."	( Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73. Burd, R; Limesand, KH; Mendoza, EE; Mitchell, GC; Radhakrishnan, VM; Sittadjody, S; Thangasamy, T, 2010)	1.8
" However, flavonoid bioavailability is often poor probably due to their interaction with plasma proteins."	( Flavonoid binding to human serum albumin. Ascenzi, P; Bolli, A; Fanali, G; Fasano, M; Marino, M; Rimbach, G, 2010)	0.36
" However, bioavailability of quercetin is a concern for such treatment."	( Formulation and evaluation of quercetin polycaprolactone microspheres for the treatment of rheumatoid arthritis. Krithica, N; Madhan, B; Natarajan, V; Sehgal, PK, 2011)	0.95
" We examined the effect of alpha-oligoglucosylation of the sugar moiety of quercetin monoglucoside on its bioavailability in humans."	( alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans. Fujikura, Y; Kashino, Y; Kato, Y; Koda, T; Matsuda, N; Murota, K; Nakamura, T; Okuyama, S; Sekido, K; Shimizu, R; Tanaka, H; Terao, J, 2010)	0.82
" The findings presented in this work provide evidence concerning the bioavailability of almond skin polyphenols considering the effects of both phase II and microbial metabolism."	( Targeted analysis of conjugated and microbial-derived phenolic metabolites in human urine after consumption of an almond skin phenolic extract. Andrés-Lacueva, C; Bartolomé, B; Garrido, I; Gómez-Cordovés, C; Llorach, R; Martín-Alvarez, PJ; Monagas, M; Urpi-Sarda, M, 2010)	0.36
" Since their low bioavailability is a major obstacle to biomedical applications, efforts are being made to improve their absorption and slow down phase II metabolism."	( Determination of quercetin and resveratrol in whole blood--implications for bioavailability studies. Biasutto, L; Garbisa, S; Marotta, E; Paradisi, C; Zoratti, M, 2010)	0.7
"The flavonol quercetin in plants and foods occurs predominantly in the form of glycoside whose sugar moiety affects the bioavailability and the mechanism of its biological activities."	( Transformation of rutin to antiproliferative quercetin-3-glucoside by Aspergillus niger. Ahn, HJ; Ji, GE; You, HJ, 2010)	0.99
" The ATP-binding cassette efflux transporter, breast cancer resistance protein (Bcrp, Abcg2), is involved in the transport of quercetin and represents a possible mechanism for the low bioavailability of quercetin."	( The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. An, G; Gallegos, J; Morris, ME, 2011)	0.8
" Although bioavailability was variable depending on the source, a healthy diet contains amounts of quercetin that might give sufficient amounts in brain to induce, by monoamine oxidase A inhibition, a small decrease in neurotransmitter breakdown."	( Dietary inhibitors of monoamine oxidase A. Dixon Clarke, SE; Ramsay, RR, 2011)	0.59
" The results demonstrated that the tricin-alanine-glutamic acid conjugate exhibited enhanced permeability, stability in MDCK cells, and excellent bioavailability after oral administration in Crl:CD (SD) male rats."	( Increased bioavailability of tricin-amino acid derivatives via a prodrug approach. Koketsu, M; Muto, Y; Ninomiya, M; Tanaka, K; Tsuchida, Y; Watanabe, K, 2011)	0.37
"With the aim to enhance dissolution rate and oral bioavailability of quercetin, a poorly water-soluble drug, quercetin loaded nanosuspension (QT-NS) was fabricated by a tandem of nano-precipitation (NP) and high pressure homogenization (HPH) method."	( Development of nanosuspension formulation for oral delivery of quercetin. Cao, F; Gao, Y; Guo, C; Li, H; Pei, Y; Sun, M; Yu, A; Zhai, G, 2010)	0.83
" Future studies should be designed to account for a disease process in which the pathogenic factors may take place for years before disease manifestations take place, the possibly limited bioavailability of polyphenols, and the potential need to provide combinations or modifications of polyphenols."	( Polyphenols: planting the seeds of treatment for the metabolic syndrome. Cherniack, EP, 2011)	0.37
" Quercetin significantly decreased bioavailability of enrofloxacin and its transformation to ciprofloxacin."	( Pharmacokinetic-pharmacodynamic indices of enrofloxacin in Escherichia coli O78/H12 infected chickens. Haritova, A; Lashev, L; Lutckanov, M; Petrov, V; Urumova, V, 2011)	1.28
" In conclusion, quercetin and rutin decreased the bioavailability of CSP through activating P-gp and CYP3A."	( Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4. Chao, PD; Chen, CT; Hou, YC; Lin, SP; Tsai, SY; Wu, PP; Yu, CP, 2011)	2.16
" The purpose of this study was to investigate the effect of oral quercetin on the bioavailability and pharmacokinetics of orally and intravenously administered doxorubicin in rats."	( Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin. Choi, JS; Kang, KW; Piao, YJ, 2011)	1
" The absorption rate of flavonoid glycoside was lower than that of aglycone; the flavonoids from Abelmoschus manihot flowers could be absorbed in all of the intestinal segments."	( [Absorption of flavonoids from Abelmoschus manihot extract by in situ intestinal perfusion]. Duan, JA; Guo, JM; Qian, DW; Shu, Y; Xue, CF, 2011)	0.37
" The bioavailability of quercetin in humans may be influenced by the food matrix in which it is consumed as well as by its chemical and physical form."	( Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules. Adolphi, B; Bosy-Westphal, A; Egert, S; Hubbermann, EM; Langguth, P; Müller, MJ; Rimbach, G; Schulze, B; Schwarz, K; Wolffram, S, 2012)	0.93
" The cocrystals outperformed QUE dihydrate with increases in bioavailability up to nearly 10-fold."	( Cocrystals of quercetin with improved solubility and oral bioavailability. Kavuru, P; Shytle, RD; Smith, AJ; Wojtas, L; Zaworotko, MJ, 2011)	0.73
"In current study, a self-nanoemulsifying drug delivery system (SNEDDS) of persimmon (Diospyros kaki) leaf extract (PLE) was developed and characterized to compare its in vitro dissolution and relative bioavailability with commercially available tablets (Naoxinqing tablets)."	( Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies. Chen, S; Li, W; Wang, Z; Xie, J; Xin, S; Yi, S; Zhao, C, 2011)	0.37
" In addition, the bioavailability of quercetin to the lens is considered."	( Eye lens in aging and diabetes: effect of quercetin. Karasu, C; Stefek, M, 2011)	0.91
" Antioxidant flavonoids such as quercetin have been reported to be beneficial to human health, but their low water solubility and bioavailability limit their enteric administration."	( Study of quercetin-loaded liposomes as potential drug carriers: in vitro evaluation of human complement activation. Caleiro Seixas Azzolini, AE; Chrysostomo, TN; de Oliveira, CA; Landi-Librandi, AP; Lucisano-Valim, YM; Marzocchi-Machado, CM, 2012)	1.08
" The concurrent targeting of quercetin's multiple bioactivities presents a potent chemopreventative strategy, but because bioavailability of quercetin is poor it will be necessary to develop quercetin analogs to maximize the full chemopreventative potential of the compound."	( Quercetin as a systemic chemopreventative agent: structural and functional mechanisms. Burd, R; Mendoza, EE, 2011)	2.1
" We conclude that NQC with greater bioavailability offers significantly higher potency in downregulating MMP-9 and NOS-2 as well as oxidative stress in blocking ethanol-induced gastric ulcer."	( The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat. Chakraborty, S; Choudhury, ST; Das, N; Ghosh, S; Stalin, S; Swarnakar, S, 2012)	0.72
" The effect of quercetin on bioavailability and metabolism of GTPs was confirmed in vivo."	( Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo. Heber, D; Henning, SM; Wang, P, 2012)	2.17
" Consumption of the OP led to faster absorption, higher concentration, and greater bioavailability as compared to the AP."	( Pharmacokinetics of quercetin absorption from apples and onions in healthy humans. Lee, J; Mitchell, AE, 2012)	0.7
"Our results suggest that the mechanisms through ISQ and extracts of Tropaeolum majus increase diuresis in SHR rats are mainly related to ACE inhibition, increased bioavailability of bradykinin, PGI2, and nitric oxide, besides an inhibitory effect on Na(+)/K(+)-ATPase."	( Mechanisms underlying the diuretic effects of Tropaeolum majus L. extracts and its main component isoquercitrin. Da Silva-Santos, JE; Gasparotto Junior, A; Gasparotto, FM; Kassuya, CA; Leme, Tdos S; Lourenço, EL; Marques, MC; Prando, TB; Rattmann, YD, 2012)	0.38
") bioavailability of glucosamine."	( Absorption and bioavailability of glucosamine in the rat. Aghazadeh-Habashi, A; Gilzad-kohan, MH; Ibrahim, A; Jamali, F, 2012)	0.38
" The bioavailability of isorhamnetin, quercetin and kaempferol in rats remarkably increased after oral administration of TFH SD formulations compared to TFH, but there was no significant increase after oral administration of TFH SE formulations."	( Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. Duan, J; Li, G; Lin, G; Luo, H; Xie, Y; Yuan, X; Zhao, G, 2013)	0.86
"Glycosylation is an important method for the structural modification of various flavonols, resulting in the glycosides with increased solubility, stability and bioavailability compared with the corresponding aglycone."	( Synthesis of flavonol 3-O-glycoside by UGT78D1. Fang, Q; Hou, J; Liu, X; Ren, G; Sun, H; Wang, PG; Zhang, L, 2012)	0.38
"The aim of our study was to enhance the bioavailability of ranolazine by using herbal-bioenhancer quercetin in rats and to study the role of P-glycoprotein (P-gp) in vitro models."	( Influence of quercetin on the pharmacokinetics of ranolazine in rats and in vitro models. Babu, KN; Babu, PJ; Babu, PR; Peter, PL; Rajesh, K, 2013)	0.98
" This is in part due to low bioavailability in plasma and in the brain, as well as the nature of the actual active molecules."	( Life or death: neuroprotective and anticancer effects of quercetin. Dajas, F, 2012)	0.62
" Although quercetin and quercetin-containing plants exhibit potential as therapeutic modalities in neuropathology and in cancer, the data collectively highlight the need to elucidate issues such as bioavailability as well as its correlation with effectiveness at biomarkers in vivo."	( Life or death: neuroprotective and anticancer effects of quercetin. Dajas, F, 2012)	1.03
" High-performance liquid chromatography coupled to time-of-flight mass spectrometry (HPLC-ESI-TOF-MS) was used for the bioavailability study."	( Bioavailability study of a polyphenol-enriched extract from Hibiscus sabdariffa in rats and associated antioxidant status. Barrajón-Catalán, E; Beltrán-Debón, R; Borrás-Linares, I; Fernández-Arroyo, S; Fernández-Gutiérrez, A; Herranz-López, M; Joven, J; Micol, V; Segura-Carretero, A, 2012)	0.38
"The bioavailability of quercetin has been intensively investigated in monogastric species, but knowledge about its bioavailability in ruminants does not exist."	( Bioavailability of the flavonol quercetin in cows after intraruminal application of quercetin aglycone and rutin. Berger, LM; Blank, R; Metges, CC; Wein, S; Wolffram, S, 2012)	0.97
" Direct antioxidant effect of flavonoids in vivo was not apparent probably due to low bioavailability although indirect redox effects through stimulation of the antioxidant response element cannot be excluded."	( Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Duthie, G; Morrice, P, 2012)	0.38
" A single dose of Q aglycone reduces BP in hypertensive men through a mechanism that is independent of changes in ACE activity, ET-1, or nitric oxide bioavailability and without affecting vascular reactivity."	( Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide. Bruno, RS; Guo, Y; Ives, S; Jalili, T; Larson, A; Richardson, RS; Symons, JD; Witman, MA, 2012)	0.83
" The bioavailability and pharmacokinetic properties of quercetin are influenced by the type of sugars attached to the molecule."	( Production of 3-O-xylosyl quercetin in Escherichia coli. Kim, BG; Malla, S; Pandey, RP; Simkhada, D; Sohng, JK, 2013)	0.94
") should be further investigated and be explored to obtain higher bioavailability and better activity for hyperoside."	( Application of microdialysis for elucidating the existing form of hyperoside in rat brain: comparison between intragastric and intraperitoneal administration. Duan, JA; Guo, JM; Lin, P; Qian, DW; Shang, EX; Tang, YP, 2012)	0.38
" In order to maximize the bioavailability of quercetin for its use in efficacy studies, it is important to determine its ideal oral carrier system and route for its delivery."	( Comparison of quercetin pharmacokinetics following oral supplementation in humans. Clarkson, PM; Conca, KR; Dunne, CP; Kaushik, D; Michniak-Kohn, B; O'Fallon, K, 2012)	1
" Following the oral administration of clopidogrel with or without the P-gp inhibitors, quercetin (250 mg/kg), telmisartan (8 mg/kg), and cyclosporine A (10 mg/kg), in rats and dogs, the plasma concentration-time profiles of clopidogrel carboxylic acid, a surrogate marker for the bioavailability of clopidogrel, were determined."	( Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs. Lee, JH; Lee, YJ; Oh, JH; Shin, YJ, 2012)	0.86
"Many bioactive compounds are hydrophobic materials that are crystalline at ambient and body temperatures, which reduces their bioavailability and poses challenges to their successful incorporation into pharmaceuticals and functional foods."	( Encapsulation and release of hydrophobic bioactive components in nanoemulsion-based delivery systems: impact of physical form on quercetin bioaccessibility. McClements, DJ; Mendoza, S; Pool, H; Xiao, H, 2013)	0.59
"Since it is known that dietary fats improve the bioavailability of the flavonol quercetin, we purposed to investigate whether this effect is due to increased lymphatic transport of quercetin."	( Influence of fatty acid patterns on the intestinal absorption pathway of quercetin in thoracic lymph duct-cannulated rats. Cermak, R; Murota, K; Terao, J; Wolffram, S, 2013)	0.85
" Our findings of the effective reduction of amyloid aggregation of lysozyme by polyphenol mixtures in vitro are of the utter physiological relevance considering the bioavailability and low toxicity of tested phenols."	( Amyloid aggregation of lysozyme: the synergy study of red wine polyphenols. Gazova, Z; Kurin, E; Mučaji, P; Nagy, M; Siposova, K, 2013)	0.39
"Epidemiologic evidence supports that dietary quercetin reduces cardiovascular disease (CVD) risk, but its oral bioavailability is paradoxically low."	( Dietary fat increases quercetin bioavailability in overweight adults. Bruno, RS; Chun, OK; Davis, CG; Ferruzzi, MG; Guo, Y; Jalili, T; Mah, E, 2013)	0.96
"Dietary fat improves quercetin bioavailability by increasing its absorption, likely by enhancing its micellarization at the small intestine."	( Dietary fat increases quercetin bioavailability in overweight adults. Bruno, RS; Chun, OK; Davis, CG; Ferruzzi, MG; Guo, Y; Jalili, T; Mah, E, 2013)	1.02
" Furthermore, dietary sugars and flavonoids in fruits and vegetables may modulate Asc bioavailability via inhibition of small intestinal GLUT2 and GLUT8."	( Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. Al-Hasani, H; Corpe, CP; Eck, P; Levine, M; Wang, J, 2013)	0.39
" It has been shown recently that bioavailability of quercetin is low after ruminal administration in cows because of degradation by the ruminal microbiota."	( Bioavailability of quercetin from its aglycone and its glucorhamnoside rutin in lactating dairy cows after intraduodenal administration. Gohlke, A; Ingelmann, CJ; Metges, CC; Nürnberg, G; Starke, A; Wolffram, S, 2013)	0.97
" However, the low water solubility of quercetin limits its bioavailability to exhibit activity in vivo."	( Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice. Kanemaru, M; Makino, T; Mizukami, H; Okuyama, S; Shimizu, R; Tanaka, H, 2013)	0.89
" To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability."	( Bioavailability of quercetin: problems and promises. Cai, X; Dou, J; Fang, Z; Yu, A; Zhai, G, 2013)	0.72
" It was concluded that the inclusion complex could improve the aqueous solubility and bioavailability of ACADFE."	( Encapsulation of a flavonoid-rich Allium cepa L. var. agrogatum don extract in β-cyclodextrin for transdermal drug delivery. Ding, Z; Guo, Q; Wu, M; Yang, X; Zhang, B, 2013)	0.39
" The bioavailability and efficacy of antioxidants in human corneal limbal epithelial (HCLE) cells were measured to determine whether antioxidants might be beneficial constituents of lubricant eye drops."	( Bioavailability of antioxidants applied to stratified human corneal epithelial cells. Koetje, LR; Mitchell, AK; Schotanus, MP; Stoddard, AR; Ubels, JL, 2013)	0.39
"Quercetin (QT) was formulated into a novel self-emulsifying drug delivery system (SEDDS) to improve its oral bioavailability and antioxidant potential compared to free drug."	( Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: implications for drug-induced cardiotoxicity and nephrotoxicity. Jain, AK; Jain, S; Pohekar, M; Thanki, K, 2013)	2.1
" Further studies are needed to determine the bioavailability of these compounds and their possible beneficial health effects when taken by moderate beer consumption."	( Beer and beer compounds: physiological effects on skin health. Becker, T; Chen, W; Qian, F; Ring, J, 2014)	0.4
" Bioflavonoids like quercetin are reported to have poor bioavailability and limited therapeutic potential against stress induced neurological disorders."	( Quercetin along with piperine prevents cognitive dysfunction, oxidative stress and neuro-inflammation associated with mouse model of chronic unpredictable stress. Kumar, A; Rinwa, P, 2017)	2.22
" Finally, the challenges of developing flavonoid delivery systems that improve flavonoid bioavailability and their anticancer therapy potentials were summarized."	( Delivering flavonoids into solid tumors using nanotechnologies. Chen, M; Wang, S; Wang, Y; Zhang, J, 2013)	0.39
" Here, we aimed to estimate the effect of prenylation on the bioavailability of dietary quercetin (Q)."	( Prenylation enhances quercetin uptake and reduces efflux in Caco-2 cells and enhances tissue accumulation in mice fed long-term. Fujikura, Y; Kawamura, T; Matsui, N; Minekawa, S; Mukai, R; Murota, K; Nemoto, H; Terao, J; Uehara, M, 2013)	0.93
" At the same time, higher Caco-2 cell uptake revealed its potential for oral delivery, which was well corroborated with in vivo pharmacokinetics, which suggested ∼ 5-fold and ∼ 3-fold increase in oral bioavailability as compared to the free Tmx citrate and free QT, respectively."	( Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. Jain, AK; Jain, S; Thanki, K, 2013)	0.67
" These effects are associated with improvements in nitric oxide bioavailability and are critically related to arterial induction of HO-1."	( Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1. Croft, KD; Hodgson, JM; Maghzal, GJ; Puddey, IB; Shen, Y; Stocker, R; Wang, Y; Ward, NC; Zhang, D, 2013)	0.82
" These data suggest that the inhibition of SULTs by flavonoids and in vivo flavonoid conjugates may modify the bioavailability of dietary hydroxycinnamic acids by suppressing their conversion to sulfated metabolites."	( Inhibition of hydroxycinnamic acid sulfation by flavonoids and their conjugated metabolites. Williamson, G; Wong, CC, )	0.13
" Quercetin glucosides, which are enzymatically trans-glycosylated isoquercitrin, have high water-solubility and bioavailability compared with quercetin."	( Quercetin glucosides promote ischemia-induced angiogenesis, but do not promote tumor growth. Ohki, T; Sata, M; Shibata, H; Sumi, M; Tateishi, N, 2013)	2.74
"Quercetin (Q), a common dietary flavonoid, has gained research attention in cancer chemo-prevention, but its low level of aqueous solubility, stability, cellular bioavailability has limited its application."	( Quercetin-nanostructured lipid carriers: characteristics and anti-breast cancer activities in vitro. Fan, Z; Nie, S; Pan, X; Sun, M; Wang, S; Zhang, R, 2014)	3.29
"The chemopreventive activity of green tea (GT) is limited by the low bioavailability and extensive methylation of GT polyphenols (GTPs) in vivo."	( Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea. Doan, N; Heber, D; Henning, SM; Magyar, CE; Said, JW; Vadgama, JV; Wang, P, 2014)	0.63
"The biochemical activities of plant flavonoids and stilbenoids point to many health-related applications, hampered however by a low bioavailability associated with rapid metabolic modification."	( Prodrugs of quercetin and resveratrol: a strategy under development. Biasutto, L; Zoratti, M, 2014)	0.78
" More research is needed to overcome the issues of poor water solubility and relatively low bioavailability of quercetin as the major obstacles limiting its clinical use."	( Site-specific anticancer effects of dietary flavonoid quercetin. Sak, K, 2014)	0.86
" However, the generally low solubility, stability, bioavailability and target specificity, together with the side effects seen when used at high levels, have limited their application."	( Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. Moustaid-Moussa, N; Nie, S; Su, R; Sun, M; Wang, S; Wu, D; Zhang, J, 2014)	0.4
"This study aims to improve the drug oral bioavailability by co-administration with flavonoid inhibitors of the CYP2C isozyme and to establish qualitative and quantitative (QSAR) structure-activity relationships (SAR) between flavonoids and CYP2C."	( Dietary flavonoids modulate CYP2C to improve drug oral bioavailability and their qualitative/quantitative structure-activity relationship. Hsiong, CH; Hu, OY; Lee, MS; Pao, LH; Shih, TY; Wang, HJ, 2014)	0.4
" However, poor oral bioavailability of these flavonoids limits the clinical applications of TFH."	( Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. Duan, J; Hong, C; Ji, G; Li, G; Luo, H; Ma, P; Wu, T; Xie, Y; Zhang, T, 2014)	0.65
"The oral bioavailability of isorhamnetin, kaempferol, and quercetin in TFH was enhanced by the co-administration of IP6."	( Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. Duan, J; Hong, C; Ji, G; Li, G; Luo, H; Ma, P; Wu, T; Xie, Y; Zhang, T, 2014)	0.89
"Quercetin is a dietary flavonoid with potential chemoprotective effects, but has low bioavailability because of poor aqueous solubility and low intestinal absorption."	( Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability. Bruno, RS; Guo, Y; Lu, X; Song, D; Tran, TH, 2014)	3.29
" Isorhamnetin was poorly absorbed by both passive diffusion and active transport mechanisms."	( Transport characteristics of isorhamnetin across intestinal Caco-2 cell monolayers and the effects of transporters on it. Duan, J; Li, G; Luo, H; Wu, T; Xie, Y; Zhang, T, 2014)	0.4
"Biological activities of flavonoids in vivo are ultimately dependent on the systemic bioavailability of the aglycones as well as their metabolites."	( A physiologically based kinetic (PBK) model describing plasma concentrations of quercetin and its metabolites in rats. Boonpawa, R; Punt, A; Rietjens, IM; Spenkelink, A, 2014)	0.63
" Our results suggest that polyphenolic compounds might be potential structural bases and source to find and project nature-based, safe, orally bioavailable direct thrombin inhibitors."	( Thrombin inhibitory activity of some polyphenolic compounds. Bijak, M; Krotkiewski, H; Nowak, P; Pawlaczyk, I; Ponczek, M; Saluk, J; Wachowicz, B; Ziewiecki, R, 2014)	0.4
" Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions."	( Isoquercitrin: pharmacology, toxicology, and metabolism. Bancířová, M; Křen, V; Ulrichová, J; Valentová, K; Vrba, J, 2014)	0.66
" These nanocrystalline drugs have enhanced solubility in neutral aqueous medium at room temperature and thus exhibit better bioavailability than their commercially available microcrystalline form."	( A lucid build-up of nanostructured curcumin, quercetin and their interaction with DNA. Annaraj, J; Rajasekaran, M, 2014)	0.66
" The goal of loading quercetin into nanoparticles was to improve its permeation across the blood-brain barrier into the brain, and its bioavailability to reach target cells."	( Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. Badilli, U; Biasi, F; Calfapietra, S; Cavalli, R; Gamba, P; Gargiulo, S; Guina, T; Leonarduzzi, G; Maina, M; Poli, G; Testa, G, 2014)	1
"The current review emphasizes on the herbal bioenhancers which themselves do not possess inherent pharmacological activity of their own but when co-administered with Active Pharmaceutical Ingredients (API), enhances their bioavailability and efficacy."	( Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients. Alexander, A; Kumari, L; Qureshi, A; Saraf, S; Sharma, M; Vaishnav, P, 2014)	0.4
" However, its low bioavailability is a major obstacle for biomedical applications, so the experiment is designed to prepare taxifolin nanoparticles by liquid antisolvent precipitation (LAP) to improve its bioavailability."	( Enhancement of solubility, antioxidant ability and bioavailability of taxifolin nanoparticles by liquid antisolvent precipitation technique. Li, Y; Wang, W; Wu, W; Zhang, Y; Zhao, X; Zhong, C; Zu, Y, 2014)	0.4
" The bioavailability of Quercetin was lowered from the polyherbal formulation when compared with the co-administration, whereas the Rutin bioavailability has increased from the polyherbal formulation when compared with the co-administration."	( Comparative pharmacokinetic interactions of Quercetin and Rutin in rats after oral administration of European patented formulation containing Hipphophae rhamnoides and Co-administration of Quercetin and Rutin. Agrawal, A; Chintala, J; Dubey, GP; Kaliappan, I; Kammalla, AK; Ramasamy, MK, 2015)	0.99
" However, the bioavailability of flavonoids across the blood-brain barrier and the localization in the brain remain controversial."	( Specific localization of quercetin-3-O-glucuronide in human brain. Ishisaka, A; Kawai, Y; Mukai, R; Shibata, N; Terao, J, 2014)	0.71
"Quercetin (QUE) is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when orally administered."	( Chitosan-xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin. Caddeo, C; Díez-Sales, O; Fadda, AM; Manconi, M; Merino-Sanjuán, M; Nácher, A, 2014)	2.06
"To prepare chitosan/xanthan gum microparticles to increase QUE oral bioavailability and optimize its release in the colon."	( Chitosan-xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin. Caddeo, C; Díez-Sales, O; Fadda, AM; Manconi, M; Merino-Sanjuán, M; Nácher, A, 2014)	0.62
"An amphiphilic carboxymethyl chitosan-quercetin (CQ) conjugate was designed and synthesized for oral delivery of paclitaxel (PTX) to improve its oral bioavailability by increasing its water solubility and bypassing the P-gp drug efflux pumps."	( Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel. Chen, Y; Dahmani, FZ; Wang, X; Yao, J; Yin, L; Zhou, J, 2014)	0.95
" Their efficacy has been tested in tumor xenografted mice and considerable experimental findings have stimulated researchers to further improve the bioavailability of these nutraceuticals."	( Targeting cancer with nano-bullets: curcumin, EGCG, resveratrol and quercetin on flying carpets. Aras, A; Farooqi, AA; Hechenleitner, AA; Khokhar, AR; Pineda, EA; Qureshi, MZ; Silva, MF; Sobczak-Kupiec, A, 2014)	0.64
" The present work is aimed to enhance the bioavailability of etoposide by co-administering it with quercetin (a P-gp inhibitor) in dual-loaded polymeric nanoparticle formulation."	( Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations. Fatma, S; Goswami, DG; Iqbal, Z; Negi, LM; Panda, AK; Talegaonkar, S; Tariq, M, 2016)	0.65
" Our data indicated that liposomal quercetin can significantly improve the solubility and bioavailability of quercetin and can be used as an effective antioxidant for ROS protection within the polar cytoplasm, and the nano-sized quercetin encapsulated by liposomes enhanced the cellular uptake (cancer cell human MCF_7)."	( Intracellular ROS protection efficiency and free radical-scavenging activity of quercetin and quercetin-encapsulated liposomes. Barzegar, A; Eidi, A; Rezaei-Sadabady, R; Zarghami, N, 2016)	0.94
" Derivatives are under development with the aim of improving their bioavailability and/or bioefficacy."	( Improving the efficacy of plant polyphenols. Azzolini, M; Biasutto, L; Mattarei, A; Paradisi, C; Romio, M; Sassi, N; Zoratti, M, 2014)	0.4
" Our study highlights a novel mechanism for the regulation of iron bioavailability by dietary polyphenols."	( Quercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro. Balesaria, S; Debnam, ES; Hoque, R; Lesjak, M; Sharp, PA; Skinner, V; Srai, SK, 2014)	1.85
" In this context, we reviewed the sometimes paradoxical antioxidant properties of quercetin and the functional role of its glucuronide and/or sulfate conjugates to discuss the low bioavailability of the molecule measured in vivo."	( The pleiotropic flavonoid quercetin: from its metabolism to the inhibition of protein kinases in chronic lymphocytic leukemia. Russo, GL; Russo, M; Spagnuolo, C, 2014)	0.93
" The knowledge of this process would be useful to understand the bioavailability of these compounds."	( Stability of iron-quercetin complexes in synthetic wine under in vitro digestion conditions. Altamirano, JC; Camargo, AB; Escudero, LB; Fusari, CM; Wuilloud, RG, 2014)	0.74
"Proanthocyanidins (PCs) with poor bioavailability were argued for their health benefits."	( Characterisation of water-soluble proanthocyanidins of Pyracantha fortuneana fruit and their improvement in cell bioavailable antioxidant activity of quercetin. Lei, DJ; Song, GH; Xu, H; Yu, LJ; Zhang, H; Zhao, CF, 2015)	0.62
" Considering the low bioavailability of quercetin, appropriate regulation of MATE1 expression may optimize cellular quercetin concentrations and promote health benefits."	( Multidrug and toxic compound extrusion protein-1 (MATE1/SLC47A1) is a novel flavonoid transporter. Jun, HJ; Kim, Y; Lee, H; Lee, JE; Lee, JH; Lee, SJ, 2014)	0.67
"Quercetin bioavailability exhibits high interindividual variation for reasons that remain unclear."	( Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults. Bruno, RS; Guo, Y; Mah, E, )	3.02
" Greater quercetin absorption and bioavailability may be associated with poor vitamin C status and increased intestinal permeability in healthy adults."	( Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults. Bruno, RS; Guo, Y; Mah, E, )	1.99
"This study selected γ-cyclodextrin (γ-CD) as the inclusion material and prepared inclusion complex of taxifolin-γ-CD by the emulsion solvent evaporation and the freeze drying combination method to achieve the improvement of the solubility and oral bioavailability of taxifolin."	( The high water solubility of inclusion complex of taxifolin-γ-CD prepared and characterized by the emulsion solvent evaporation and the freeze drying combination method. Li, Y; Wu, W; Zhang, Y; Zhao, X; Zhong, C; Zu, Y, 2014)	0.4
" Concurrently, investigations aimed at improvement of the bioavailability of Q and further elucidation of its metabolism after application in combination with anthracyclines are needed."	( The flavonoid quercetin: possible solution for anthracycline-induced cardiotoxicity and multidrug resistance. Czepas, J; Gwoździński, K, 2014)	0.76
" Bioavailability of dietary constituents is a critical mediator of their health benefits."	( Endogenous and exogenous mediators of quercetin bioavailability. Bruno, RS; Guo, Y, 2015)	0.69
" After oral administration of TFH-PC in rats, the bioavailability of isorhamnetin, kaempferol, and quercetin in TFH-PC relative to TFH was 223%, 172%, and 242%, respectively."	( A phospholipid complex to improve the oral bioavailability of flavonoids. Cui, Y; Deng, B; Fu, Q; Li, G; Wang, H; Wu, T; Xie, Y; Yang, J, 2015)	0.63
" In vivo oral bioavailability study was conducted for 1:2 binary amorphous form by using pure RTV as a control."	( Fabrication, solid state characterization and bioavailability assessment of stable binary amorphous phases of Ritonavir with Quercetin. Bhat, K; Dengale, SJ; Gautham Shenoy, G; Hussen, SS; Krishna, BS; Musmade, PB, 2015)	0.62
" These findings suggested that the oral bioavailability of isorhamnetin and quercetin in beagle dogs can be significantly increased in TFH-SD and TFH-SE preparations compared to TFH preparations, which was helpful to explore the new forms for oral administration TFH and explain their in vivo processes."	( A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration. Dang, Y; Duan, J; Li, G; Ma, P; Meng, H; Wang, H; Wu, T; Xie, Y, 2016)	0.66
"Despite their strong role in human health, poor bioavailability of flavonoids limits their biological effects in vivo."	( Antiproliferative activity of long chain acylated esters of quercetin-3-O-glucoside in hepatocellular carcinoma HepG2 cells. Rupasinghe, HV; Sudan, S, 2015)	0.66
"The physiological functions and bioavailability of flavonoids have been widely investigated since their bioactivities were identified about 80 years ago."	( Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability. Ishisaka, A; Kawabata, K; Mukai, R, 2015)	1.86
" The aim of this study was to investigate the oral bioavailability of the flavonol quercetin, applied either as quercetin aglycone (QA) or as its glucorhamnoside rutin (RU), in newborn dairy calves."	( Bioavailability of the flavonol quercetin in neonatal calves after oral administration of quercetin aglycone or rutin. Bruckmaier, RM; Hammon, HM; Kanitz, E; Maciej, J; Schäff, CT; Tuchscherer, A; Wolffram, S, 2015)	0.93
" We conducted a two-period, two-sequence crossover study to compare the bioavailability of quercetin when administered in the form of a fresh red onion meal (naturally glycosylated quercetin) or dietary supplement (aglycone quercetin) under fasting conditions."	( Comparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: a randomized, single-blinded, cross-over study. Shi, Y; Williamson, G, 2015)	0.91
" Therefore, a strategy to improve the solubility of quercetin in water and/or enhance the bioavailability is desired."	( Enhancing the anti-colon cancer activity of quercetin by self-assembled micelles. Gao, X; Gong, D; Gou, H; Huang, N; Ren, L; Shi, H; Xu, G, 2015)	0.93
" In addition, a scope of the new insights concerning quercetin pharmacokinetics, pharmacodynamics and bioavailability are presented."	( Cardiovascular Disease: A Target for the Pharmacological Effects of Quercetin. Gormaz, JG; Quintremil, S; Rodrigo, R, 2015)	0.9
"38-fold increase in relative bioavailability as compared with quercetin suspension (C(max), 369."	( LC-ESI-MS/MS analysis of quercetin in rat plasma after oral administration of biodegradable nanoparticles. Singh, SK; V, DK; Verma, PR; Viswanathan, S, 2015)	0.96
" Integration of these complexes into liposomes may increase their bioavailability and therapeutic effect."	( Integration of Quercetin-Iron Complexes into Phosphatidylcholine or Phosphatidylethanolamine Liposomes. Kim, YA; Kuznetsova, SM; Muzafarov, EN; Tarahovsky, YS; Yagolnik, EA, 2015)	0.77
"Quercetin (QT) is a potential bioflavonol and antioxidant with poor bioavailability and very low distribution in the brain."	( Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats. Bagad, M; Khan, ZA, 2015)	2.1
" These NPs were observed to improve the drugs' oral bioavailability and enhance their transport to the brain."	( Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats. Bagad, M; Khan, ZA, 2015)	0.66
" The blood and brain bioavailability of free quercetin after ingestion is a complex and controversial process that produces final low concentrations, a fact that has led to suggestions that metabolites would be active by themselves and/or as pro-drugs that would release the active aglycone in the brain."	( Quercetin in brain diseases: Potential and limits. Abin-Carriquiry, JA; Arredondo, F; Blasina, F; Dajas, F; Echeverry, C; Martínez, M; Rivera, F; Vaamonde, L, 2015)	2.12
" These polymeric systems can serve as prodrug carriers for the delivery of bioactive compounds which suffer from poor aqueous solubility, low bioavailability and are biologically unstable, such as the antioxidant, quercetin."	( Quercetin conjugated poly(β-amino esters) nanogels for the treatment of cellular oxidative stress. Authimoolam, SP; Dziubla, TD; Gupta, P; Hilt, JZ, 2015)	2.05
" In this study, two kinds of QC-loaded self-aggregates based on O-carboxymethyl chitosan-cholic acid conjugates (CMCA) were developed to improve the drug bioavailability in which glycyrrhetinic acid (GA) modification was utilized in the nanocarrier fabrication (QC-GA-CMCA) or not (QC-CMCA)."	( The role of glycyrrhetinic acid modification on preparation and evaluation of quercetin-loaded chitosan-based self-aggregates. Du, H; Liu, M; Yang, X; Zhai, G, 2015)	0.65
" While the drug-drug interaction potential between flavonoids and co-ingested drugs still remain an issue, opportunities exist for the combination of flavonoids with suitable anti-cancer drugs to enhance the bioavailability of anti-cancer drugs and thereby reduce the dose size of the anti-cancer drugs and improve its therapeutic index."	( Recent trends in preclinical drug-drug interaction studies of flavonoids--Review of case studies, issues and perspectives. Srinivas, NR, 2015)	0.42
" The implications for improved bioavailability of the NP formulations were supported by cytotoxicity results that showed a similar efficacy to free dual drug formulations and even enhanced anti-cancer effects in the recovery condition."	( Dual drug delivery of tamoxifen and quercetin: Regulated metabolism for anticancer treatment with nanosponges. Beezer, DB; Harth, E; Kravitz, A; Lockhart, JN; Stevens, DM, 2015)	0.69
" The bioavailability of flavonoids from fruits and vegetables is frequently affected by the manufacturing process and related conditions."	( Effect of Processed Onions on the Plasma Concentration of Quercetin in Rats and Humans. Hamano, T; Kashino, Y; Matsuda, N; Mukai, R; Murota, K; Terao, J; Tomotake, M, 2015)	0.66
" The present study estimated the effect of food processing on the bioavailability of onion quercetin aglycone and its glucosides provided through the consumption of onion products."	( Effect of Processed Onions on the Plasma Concentration of Quercetin in Rats and Humans. Hamano, T; Kashino, Y; Matsuda, N; Mukai, R; Murota, K; Terao, J; Tomotake, M, 2015)	0.88
"Quercetin is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when administered orally."	( Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin. Caddeo, C; Carbone, C; Díez-Sales, O; Ennas, G; Fadda, AM; Manconi, M; Pons, R; Puglisi, G, 2016)	2.11
" Quercetin does not alter the oral bioavailability of Atorvastatin Calcium in rats."	( Quercetin does not alter the oral bioavailability of Atorvastatin in rats. Babu, N; Challa, SR; Devi, R; Geddam, LB; Koritala, R; Ragam, SK; Sattenapalli, S; Venkatesh Reddy Challa, VR, 2015)	2.77
"Biological activities of flavonoids in vivo ultimately depend on the systemic bioavailability of the aglycones and their metabolites."	( Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites. Boonpawa, R; Moradi, N; Punt, A; Rietjens, IM; Spenkelink, A, 2015)	0.62
" Despite the potential use of Qu in clinical trials, low water solubility, stability problems and the scarcity of cellular bioavailability limit its applications."	( Characterization and Antioxidant Activity of Quercetin/Methyl-β-Cyclodextrin Complexes. Demirel, M; Güleç, K, 2016)	0.69
" However, the oral bioavailability of this compound is very low due to the high pre-systemic metabolism in the colon and liver and its low water solubility."	( Lipid-based nanocarrier for quercetin delivery: system characterization and molecular interactions studies. Bidone, J; de Lima, VR; Dora, CL; Hädrich, G; Monteiro, SO; Muccillo-Baisch, AL; Putaux, JL; Rodrigues, MR; Teixeira, HF, 2016)	0.73
" However, the clinical application of this flavonol is limited by its poor bioavailability and low stability in aqueous medium."	( Quercetin derivatives as novel antihypertensive agents: Synthesis and physiological characterization. Angelone, T; Brancale, A; Cantafio, P; Cerra, MC; Ferla, S; Grande, F; Mordocco, RA; Parisi, OI; Puoci, F; Quintieri, AM; Rocca, C; Saturnino, C; Scrivano, L; Sinicropi, MS, 2016)	1.88
" Quercetin has potent anti-oxidative activities, but poor bioavailability limits its therapeutic application."	( Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway. Ding, SH; Hang, L; Xu, XR; Yang, XW; Yang, Y; Yu, HT, 2016)	2.79
" Problems like low oral bioavailability and poor aqueous solubility make quercetin an unreliable candidate for therapeutic purposes."	( Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine. Chakraborty, C; Lee, SS; Nam, JS; Nguyen, LT; Sharma, AR; Sharma, G, 2016)	0.97
" While senolytic treatment significantly improved vasomotor function (isolated organ chamber baths) in both groups of mice, this was due to increases in nitric oxide bioavailability in aged mice and increases in sensitivity to NO donors in hypercholesterolemic mice."	( Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice. Casaclang-Verzosa, G; Hagler, M; Jurk, D; Kirkland, JL; Miller, JD; Ogrodnik, MB; Palmer, AK; Pirtskhalava, T; Roos, CM; Schafer, MJ; Smith, LA; Tchkonia, T; Thalji, NM; Zhang, B; Zhu, Y, 2016)	0.43
" However, its poor bioavailability and moderate potency hinder its advancement into clinical therapy."	( Synthesis and Anti-Proliferative Effects of Quercetin Derivatives. Al-Jabban, SM; Chen, G; Chen, QH; Mekuria, EA; Rakotondraibe, LH; Zhang, X, 2015)	0.68
" We also briefly discuss the approaches to improve the bioavailability of quercetin."	( Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis. Arumugam, S; Giridharan, VV; Karuppagounder, V; Sreedhar, R; Thandavarayan, RA; Watanabe, K, 2016)	0.98
"A strategy to circumvent the poor polyphenols bioavailability is to load these compounds into liposomes."	( Effect of Quercetin-loaded liposomes on induced oxidative stress in human spermatozoa. Bonechi, C; Collodel, G; Iacoponi, F; Mazzi, L; Moretti, E; Rossi, C; Salvatici, MC, 2016)	0.84
"Xiebai in Gualou Xiebai decoction has a remarkable effect on pharmacokinetic character of quercetin in Gualou, it can promote the absorption and distribution and reduce the elimination of quercetin, in vivo, as well as increase the bioavailability of quercetin."	( [Influence of the Compatibility of Gualou and Xiebai on Pharmacokinetics of Quercetin in Gualou]. Chen, XJ; Huang, X; Wei, ML; Yan, HY; Zhang, YH; Zou, CC, 2015)	0.87
" Quercetin (QU) is a polyphenol that has an antioxidant effect in vitro, but due to its high lipophilicity, it has low bioavailability in vivo."	( Protective role of free and quercetin-loaded nanoemulsion against damage induced by intracerebral haemorrhage in rats. Antunes, MF; Barros, DM; Cordeiro, MF; Dora, CL; Galho, AR; Hädrich, G; Horn, AP; Lima, JV; Luz, DC; Marques, MS; Muccillo-Baisch, AL; Ribeiro, SA, 2016)	1.64
" This review focuses on the physicochemical properties, dietary sources, absorption, bioavailability and metabolism of quercetin, especially main effects of quercetin on inflammation and immune function."	( Quercetin, Inflammation and Immunity. Chaudhry, MT; Han, C; Li, Y; Liu, H; Wang, S; Yang, J; Yao, J; Yin, Y, 2016)	2.09
"The aim of this study was to develop hyperoside (Hyp) nanocrystals to enhance its dissolution rate, oral bioavailability and anti-HBV activity."	( Hyperoside nanocrystals for HBV treatment: process optimization, in vitro and in vivo evaluation. Han, J; Lu, Y; Shen, B; Shen, C; Wang, Y; Wu, N; Wu, W; Wu, Y; Xu, P; Yuan, H; Zhang, F; Zhang, L, 2016)	0.43
" These activities, associated to a good predictive bioavailability and a lack of cytotoxicity, design it as a promising hit for further in vivo investigation."	( Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment. Corvaisier, S; Cresteil, T; Dallemagne, P; El Kihel, L; Jourdan, JP; Lecoutey, C; Legay, R; Malzert-Fréon, A; Rochais, C; Since, M; Sopkova-de Oliveira Santos, J, 2016)	0.43
" The aim of this study was to develop a lecithin-based mixed polymeric micelle (LMPM) delivery system to improve the solubility and bioavailability of Que."	( Development and characterization of self-assembling lecithin-based mixed polymeric micelles containing quercetin in cancer treatment and an in vivo pharmacokinetic study. Chen, LC; Chen, YC; Ho, HO; Hong, CS; Sheu, MT; Su, CY, 2016)	0.65
" Certain flavonoids, in particular quercetin, have been shown to ameliorate endothelial dysfunction and reduce blood pressure (BP), possibly by increasing the bioavailability of the potent vasodilator nitric oxide (NO)."	( Acute effects of quercetin-3-O-glucoside on endothelial function and blood pressure: a randomized dose-response study. Bondonno, CP; Bondonno, NP; Croft, KD; Hodgson, JM; Mas, E; Rich, L; Shinde, S; Ward, NC, 2016)	1.05
" Flavonoid bioavailability and bioactivity depend on structure, conjugation and the cell type to which they are presented."	( Flow Cytometric Method for the Detection of Flavonoids in Cell Lines. Gonzales, GB; Grootaert, C; Raes, K; Smagghe, G; Van Camp, J; Van de Wiele, T; Vissenaekens, H, 2016)	0.43
"Plant polyphenols showed useful biochemical characteristics in vitro; however, the assessments of their clinical applications in vivo are restricted by their limited bioavailability due to their strong resistance to 1st-pass effects during absorption."	( Esterification of Quercetin Increases Its Transport Across Human Caco-2 Cells. Chen, F; Deng, ZY; He, Y; Hu, JN; Zou, XG, 2016)	0.77
"The tranquillizing effects of quercetin on allergic asthma are promising, but its poor water solubility and bioavailability is still a bottleneck."	( Reversion of Asthmatic Complications and Mast Cell Signalling Pathways in BALB/c Mice Model Using Quercetin Nanocrystals. Chaudhari, BP; Das, M; Dwivedi, PD; Gupta, K; Gupta, RK; Kumar, S; Sharma, A; Singh, SP; Stalin, K; Verma, AK, 2016)	0.94
" Hence, in order to enhance the bioavailability of curcumin, we combined it with the bioavailability enhancers like piperine and quercetin."	( Influence of piperine and quercetin on antidiabetic potential of curcumin. Chintamaneni, M; Invally, M; Kaur, G, 2016)	0.94
" Low aqueous solubility of quercetin limits its bioavailability and hence therapeutic effects."	( Development and evaluation of PLGA polymer based nanoparticles of quercetin. Al-Mansoor, MA; Al-Shdefat, R; Ansari, MN; Anwer, MK; Jamil, S; Shakeel, F, 2016)	0.97
" However, poor water solubility as well as less bioavailability has confined its use as a suitable anti-cancer drug."	( Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells. Chowdhury, S; Ghosh, S; Pandey, B; Sarkar, A; Sil, PC, 2016)	0.75
"MSN-FA-Q facilitates higher cellular uptake and allows more drug bioavailability to the breast cancer cells with over-expressed folate receptors."	( Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells. Chowdhury, S; Ghosh, S; Pandey, B; Sarkar, A; Sil, PC, 2016)	0.75
" However, the bioavailability of QT is relatively low due to its low solubility which severely limits its use."	( Development of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats. Chen, X; Gu, L; Hu, G; Jia, J; Liu, Z; Zhang, K; Zhang, M; Zhang, Y, 2016)	0.79
" These results suggest that an improvement in the oral bioavailability of quercetin occurred when this compound was dissolved in the oily phase of a nanosized emulsion, indicating that it might have a potential application in the treatment of melanoma."	( Oral Delivery of a High Quercetin Payload Nanosized Emulsion: In Vitro and In Vivo Activity Against B16-F10 Melanoma. Assreuy, J; Baischl, AL; Dora, CL; Fernandes, D; Lemos-Senna, E; Maioral, MF; Mazzarino, L; Pacheco, LK; Santos-Silva, MC; Silva, LF; Siqueira, JM, 2016)	0.97
" It was demonstrated that Que was able to reduce the bioavailability of CsA following multiple concomitant doses in rats."	( Impact of quercetin‑induced changes in drug‑metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats. Liu, Y; Luo, X; Shi, S; Yang, C; Yang, T; Zhou, J, 2016)	0.84
" To provide a complete picture of QE, its distribution, chemistry, biosynthesis and bioavailability are reported."	( Hepatoprotective effect of quercetin: From chemistry to medicine. Alavian, SM; Daglia, M; Miltonprabu, S; Nabavi, SF; Nabavi, SM; Rastrelli, L; Skalicka-Woźniak, K; Tomczyk, M, 2017)	0.75
"Zein nanoparticles were evaluated as nanocarriers to promote the oral bioavailability of quercetin and, thus, improve its anti-inflammatory effect on a mouse model of induced endotoxemia."	( Zein nanoparticles for oral delivery of quercetin: Pharmacokinetic studies and preventive anti-inflammatory effects in a mouse model of endotoxemia. Esparza, I; Gamazo, C; González-Navarro, CJ; Irache, JM; Penalva, R, 2017)	0.94
" Initial studies suggested poor bioavailability of quercetin."	( The Antidiabetic Potential of Quercetin: Underlying Mechanisms. Eid, HM; Haddad, PS, 2017)	1
" The absorption of quercetin and its in vivo bioavailability were significantly improved by proliposome, which was evidenced by the in situ intestinal absorption and pharmacokinetic study."	( Quercetin-containing self-assemble proliposome preparation and evaluation. Du, Q; Fang, Z; Jiang, L; Ren, J, 2017)	2.23
" To improve bypassing P-gp drug efflux pumps and oral bioavailability of doxorubicin hydrochloride (DOX), Multilayer micro-dispersing system (MMS) was constructed by co-immobilization of DOX loaded chitosan/carboxymethyl chitosan nanogels (DOX:CS/CMCS-NGs), along with quercetin (Qu) in the core of multilayer sodium alginate beads (DOX:NGs/Qu-M-ALG-Beads)."	( Multilayer micro-dispersing system as oral carriers for co-delivery of doxorubicin hydrochloride and P-gp inhibitor. Chen, XG; Cheng, XJ; Feng, C; Kong, M; Li, J; Li, Y; Liu, Y; Mu, Y; Raja, MA, 2017)	0.63
" Quercetin glycosides have also received some attention due to their high bioavailability and activity against various diseases including cancer."	( Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases. Al Halabi, W; Al Homedi, Z; Antony, P; Baby, B; Vijayan, R, 2016)	1.59
" NLCs substantially enhanced the relative bioavailability (approx."	( Promises of a biocompatible nanocarrier in improved brain delivery of quercetin: Biochemical, pharmacokinetic and biodistribution evidences. Katare, OP; Kumar, P; Kumar, R; Malik, R; Raza, K; Sharma, G; Singh, B, 2016)	0.67
" Quercetin and quercetin-rich foods have been reported to have wide range of health promoting effects, especially in the prevention and management of several diseases; however, the subject of its solubility and bioavailability has limited its use."	( Quercetin and Its Role in Chronic Diseases. Ademosun, AO; Oboh, G; Ogunsuyi, OB, 2016)	2.79
" The aim of this work was to evaluate the capability of nanoencapsulated quercetin in zein nanoparticles (NPQ), that significantly improves the oral absorption and bioavailability of the flavonoid, as potential oral treatment for AD."	( Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer's disease. Irache, JM; Moreno, LCGEI; Puerta, E; Ramirez, MJ; Santos-Magalhães, NS; Suárez-Santiago, JE, 2017)	0.94
" However, Q bioavailability is relatively low, due to its poor aqueous solubility and extensive phase-II metabolism."	( Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro. Arca, HC; Edgar, KJ; Gilley, AD; Mosquera-Giraldo, LI; Neilson, AP; Nichols, BLB; Taylor, LS, 2017)	0.7
" The rapid gastrointestinal digestion of quercetin is also a major obstacle for its clinical implementation due to low bioavailability and poor aqueous solubility."	( 3',5-dihydroxy-3,4',7-trimethoxyflavone-induces ER-stress-associated HCT-116 programmed cell death via redox signaling. Han, J; Kang, SC; Singh, MP, 2017)	0.72
"A set of O-substituted quercetin derivatives was prepared with the aim to optimize bioavailability and redox properties of quercetin, a known agent with multiple health beneficial effects."	( Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases. Horakova, L; Prnova, M; Rackova, L; Stefek, M; Zizkova, P, 2017)	1.25
" These results, together with the innate properties of quercetin, contribute to an understanding of the low bioavailability of quercetin."	( Towards an Understanding of the Low Bioavailability of Quercetin: A Study of Its Interaction with Intestinal Lipids. Buchweitz, M; Kroon, PA; Rich, GT; Wilde, PJ; Winterbone, MS, 2017)	0.95
" However, the slow dissolution rate leading to poor bioavailability constitutes a barrier to being further developed for nutritional products."	( Preparation and characterization of quercetin/dietary fiber nanoformulations. Chan, KP; Dong, Y; Khor, CM; Ng, WK, 2017)	0.73
"The results revealed that enhanced bioavailability of rivastigmine might be caused by the combination of their effects due to CYP3A and esterase inhibition, Therefore, concomitant administration of NQC influences the bioavailability of rivastigmine and also has synergetic effect in the treatment of Alzheimer's disease."	( Enhancement of oral bioavailability of rivastigmine with quercetin nanoparticles by inhibiting CYP3A4 and esterases. Neerati, P; Palle, S, 2017)	0.7
" Numerous attempts are taken for improving the bioavailability of polyphenols in order to increase their use in the body."	( Polyphenols in preventing endothelial dysfunction. Biegańska-Hensoldt, S; Rosołowska-Huszcz, D, 2017)	0.46
" However, the optimum intake of flavonoids from supplements or diet has not been clarified yet, because a number of exogenous and endogenous factors modulating their bioavailability affect their vascular function."	( Factors modulating bioavailability of quercetin-related flavonoids and the consequences of their vascular function. Terao, J, 2017)	0.73
" This quercetin nanoparticle with a particle size of around 35 nm significantly improved the bioavailability and metabolic stability of the parent quercetin."	( Quercetin Remodels the Tumor Microenvironment To Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles. Goodwin, TJ; Hu, K; Huang, L; Li, J; Liu, Q; Miao, L, 2017)	2.38
" Different types of formulations have been designed for the improvement of bioavailability of these compounds, nanonization being one of the most notable approaches among them."	( Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective. Abdollahi, M; Bahramsoltani, R; Davatgaran-Taghipour, Y; Farzaei, MH; Karimi-Soureh, Z; Masoomzadeh, S; Rahimi, R, 2017)	0.46
"Quercetin, a dietary flavonol phytoestrogen, has many health benefits but it is poorly absorbed when administered orally."	( Enhanced therapeutic benefit of quercetin-loaded phytosome nanoparticles in ovariectomized rats. Abd El-Fattah, AI; Ali, ZY; El-Garawany, AEA; Fathy, MM; Mohamed, EK, 2017)	2.18
" DoxQ provides a novel therapeutic approach to mitigate the cardiotoxicity and poor oral bioavailability of doxorubicin."	( Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative. Alrushaid, S; Anderson, HD; Chaboyer, K; Davies, NM; El-Kadi, AOS; Forrest, ML; Maayah, ZH; Sayre, CL; Senadheera, SN; Zhao, Y, 2017)	0.46
" Concurrent administration of RES and QUR was able to enhance the bioavailability of RES."	( Co-encapsulated resveratrol and quercetin in chitosan and peg modified chitosan nanoparticles: For efficient intra ocular pressure reduction. Kandasamy, R; Muthusamy, S; Natesan, S; Palanichamy, R; Pandian, S; Ponnusamy, C, 2017)	0.74
"The effect of diabetes on the pharmacokinetics, bioavailability and brain distribution of grape polyphenols and select metabolites was studied in the Zucker diabetic fatty (ZDF) rat model."	( Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Chen, TY; Cooper, B; Ferruzzi, MG; Ho, L; Janle, EM; Pasinetti, GM; Simon, JE; Talcott, ST; Todd, G; Wang, J; Wu, QL, 2017)	0.46
"Diabetes may alter the overall bioavailability of some polyphenols in plasma and brain in part due to higher urinary clearance."	( Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Chen, TY; Cooper, B; Ferruzzi, MG; Ho, L; Janle, EM; Pasinetti, GM; Simon, JE; Talcott, ST; Todd, G; Wang, J; Wu, QL, 2017)	0.46
" To evaluate the extent of bioavailability for QMNE via post-intranasal (i."	( Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia. Abdur Rub, R; Ahmad, FJ; Ahmad, N; Ahmad, R; Alam, MA; Ashafaq, M; Naqvi, AA, 2018)	0.79
" However, a key problem is their short half-life and low bioavailability under in vivo conditions."	( Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy. Benlloch, M; Castellano, G; Dellinger, RW; Estrela, JM; Mena, S; Obrador, E; Salvador, R, 2017)	0.46
" Quite often however their instability, extensive metabolization, low bioavailability and poor solubility limit their application in cancer prevention and therapy."	( Nanoparticle formulations to enhance tumor targeting of poorly soluble polyphenols with potential anticancer properties. Bonferoni, MC; Ferrari, F; Rossi, S; Sandri, G, 2017)	0.46
" However low oral bioavailability and poor cell membrane permeability restrict its therapeutic efficacy."	( Triphenyl phosphonium coated nano-quercetin for oral delivery: Neuroprotective effects in attenuating age related global moderate cerebral ischemia reperfusion injury in rats. Choudhury, ST; Das, N; Ghosh, S; Ghosh, T; Sarkar, S, 2017)	0.73
"We hypothesized that metabolites of dietary flavonoids attenuate impairments in nitric oxide (NO) bioavailability evoked by glucotoxic conditions mimicking Type 1 or 2 diabetes."	( Metabolites of flavonoid compounds preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions. Babu, PVA; Jalili, T; Qian, Y; Symons, JD, 2017)	0.46
"Drug nanosuspension is one of the established methods to improve the bioavailability of poorly soluble drugs."	( Production of drug nanosuspensions: effect of drug physical properties on nanosizing efficiency. Liu, T; Möschwitzer, JP; Müller, RH, 2018)	0.48
" On the other hand, Q1 is poorly soluble in water and unstable in physiological systems, and its bioavailability is very low."	( New insights for the use of quercetin analogs in cancer treatment. Caruso, A; Ceramella, J; Grande, F; Iacopetta, D; Mordocco, RA; Muià, N; Plutino, MR; Puoci, F; Rosano, C; Saturnino, C; Scrivano, L; Sinicropi, MS, 2017)	0.75
"The results showed that the top 5 active compounds with a relatively higher bioavailability that interacted with 23 therapeutic targets were identified in Vernonia anthelmintica (L."	( Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. Chen, H; Chen, HY; Tang, Y; Wang, JY; Wang, XQ; Wang, YY; Zhang, B; Zhang, M, 2017)	0.46
" These biological effects suggest that FA and Qu display outstanding bioavailability and bioactivity and could be used for treatment of some metabolic syndromes, such as inflammatory bowel diseases and obesity."	( Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats. Dong, M; Tang, H; Wang, Y; Zhang, L, 2018)	0.73
" INS-LCNPs demonstrated approximately 20% relative bioavailability compared with subcutaneously administered INS."	( Insulin- and quercetin-loaded liquid crystalline nanoparticles: implications on oral bioavailability, antidiabetic and antioxidant efficacy. Agrawal, AK; Jain, S; Kushwah, V; Singh, S, 2018)	0.85
" Herein, we aimed to formulate marrubiin loaded solid lipid nanoparticles (SLNs) to improve its pharmacokinetics and bioavailability and also to investigate free drug and formulation's protective impact against intracellular reactive oxygen species (ROS) generation in HUVECs."	( Marrubiin-loaded solid lipid nanoparticles' impact on TNF-α treated umbilical vein endothelial cells: A study for cardioprotective effect. Barar, J; Eskandani, M; Garjani, A; Ghafari, S; Nakhlband, A; Omidi, Y; Saeedi, N, 2018)	0.48
" Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin."	( Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken. Bhutto, ZA; Guo, T; He, F; Huang, J; Wang, L; Yang, J; Zloh, M, 2018)	1.13
" Quercetin-3-glucoside, a naturally occurring polyphenol that has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies."	( Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice. Meng, F; Reece, EA; Tan, C; Zhao, Z, 2018)	1.62
" However, their bioavailability is hampered due to their poor aqueous solubility."	( Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus. Chatzigiannis, CM; Degano, I; Diamantis, DA; Galaris, D; Gerogianni, PS; Gerothanassis, IP; Karadima, KE; Mavromoustakos, T; Perikleous, S; Ramesova, S; Rekkas, D; Sokolova, R; Tzakos, AG; Valsami, G, 2018)	0.71
"Quercetin has a variety of biological activities and pharmacological effects, but its clinical application is limited due to its low water solubility, low bioavailability and poor chemical stability."	( [Research and application of quercetin-loaded nano drug delivery system]. Du, Q; Li, SJ; Liao, YF, 2018)	2.21
"5, 5 or 10 mg/kg) for 7 consecutive days reduced the bioavailability of oral CsA."	( Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. Huang, X; Liu, Y; Shi, S; Wan, J; Yang, C; Yang, T; Zhang, R; Zhang, Y; Zhou, J, 2018)	1.92
" Bioavailability of QCT is very low due to its poor aqueous solubility and instability."	( In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. Baksi, R; Borse, SP; Nivsarkar, M; Rana, R; Sharma, V; Singh, DP, 2018)	0.73
" 3-O-(N,N-Dibutylamino)propyl-3',4'-dimethoxyflavonol (42) emerged as the most promising derivative due to its substantially improved potency in cell models, superior bioavailability in rats, and good selectivity of inhibiting prostate cancer cell proliferation over non-neoplastic human epithelial cell proliferation."	( Structure-activity relationship and pharmacokinetic studies of 3-O-substitutedflavonols as anti-prostate cancer agents. Chen, G; Chen, QH; Fong, R; Gonzalez, A; Guo, S; Lee, M; Li, X; Rajaram, P; Wang, G; Zhang, C; Zhang, Q; Zheng, S, 2018)	0.48
"The aim of the present study was to investigate the bioavailability of quercetin from onion bulb (OB) and onion skin (OS) extracts in ruminants."	( Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows. Beyer, B; Blank, RH; Wein, S; Wolffram, S; Zimmermann, BF, 2018)	1.04
" Moreover, folic acid-bovine serum albumin (FA-BSA) conjugates are applied to stabilize the CuS@ZIF-8-QT to promote the bioavailability of quercetin and realize active-targeting drug delivery."	( CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo-Photothermal Therapy. Garg, S; Jiang, W; Li, Z; Luan, Y; Wu, J; Zhai, G; Zhang, H, 2018)	0.98
" However, the low absorption rate of QT, especially through the blood-brain barrier, restricts its bioactivity in the body."	( Using superparamagnetic iron oxide nanoparticles to enhance bioavailability of quercetin in the intact rat brain. Beheshti, S; Enteshari Najafabadi, R; Esmaeili, A; Kazemipour, N; Nazifi, S, 2018)	0.71
"The results of this study confirm that SPION as a targeted drug delivery system enhances the bioavailability of quercetin in the brain about ten folds higher than free quercetin and could be used for the treatment of neurodegenerative disorders."	( Using superparamagnetic iron oxide nanoparticles to enhance bioavailability of quercetin in the intact rat brain. Beheshti, S; Enteshari Najafabadi, R; Esmaeili, A; Kazemipour, N; Nazifi, S, 2018)	0.92
" However, the poor bioavailability of quercetin, due to its low aqueous solubility and its degradation during digestion, limits its nutraceutical applications."	( Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids. Almeda, RA; Reyes, CT; Rodriguez, EB; Vidallon, MLP, 2019)	1.04
"In this study, quercetin-chitosan conjugate (QT-CS) was synthesized for oral delivery of doxorubicin (DOX) to improve its oral bioavailability by increasing its water solubility, opening tight junction and bypassing the P-glycoprotein (P-gp)."	( Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. Chen, X; Feng, C; Fu, Y; Kong, M; Li, J; Li, Y; Mu, Y; Wang, Y; Wu, X; Yu, X; Zhang, K, 2019)	1.21
" But the therapeutic application of Qu is hampered by its low oral bioavailability and its unfavourable physicochemical characteristics."	( Design, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment. Ajmal, G; Mishra, B; Mittal, P; Singh, J; Vasant Bonde, G, 2018)	0.72
" However, its poor stability in the upper gastro-intestinal tract and low bioavailability compromised its benefits."	( A colon-specific delivery system for quercetin with enhanced cancer prevention based on co-axial electrospinning. Hu, TG; Li, L; Wen, P; Wu, H; Zong, MH, 2018)	0.75
" Enzymatically modified IQ (EMIQ) is a mixture of transglycosylated IQs that have better solubility and bioavailability than do quercetin and IQ."	( High-efficiency enzymatic production of α-isoquercitrin glucosides by amylosucrase from Deinococcus geothermalis. Choi, JM; Jung, YS; Kim, DO; Kim, ER; Ko, MJ; Park, CS; Rha, CS; Seo, DH, 2019)	0.72
"5-fold increase in bioavailability of DTX was achieved with improved antitumor efficacy and reduced in vivo toxicity."	( Chemosensitizer and docetaxel-loaded albumin nanoparticle: overcoming drug resistance and improving therapeutic efficacy. Desale, JP; Jain, S; Katiyar, SS; Kushwah, V; Swami, R, 2018)	0.48
" Current studies are focused on nano-formulations to overcome the low bioavailability of natural quercetin, which limits its clinical use as an antitumor agent."	( Potential of the Flavonoid Quercetin to Prevent and Treat Cancer - Current Status of Research. Břetislav, G; Jana, N; Pavel, S; Pavla, U, )	0.65
" However, the instability, low water solubility and low bioavailability of QT remain to be solved."	( Nanoformulations of quercetin and cellulose nanofibers as healthcare supplements with sustained antioxidant activity. Chen, W; Li, X; Liu, Y; Yu, H; Yu, Y, 2019)	0.84
" This work investigated the effects of combined cereal 3-deoxyflavonoids (apigenin, naringenin) and pulse flavonols (quercetin), along with natural extracts, on their bioavailability and underlying mechanisms using Caco-2 monolayer model."	( Combined cereal and pulse flavonoids show enhanced bioavailability by downregulating phase II metabolism and ABC membrane transporter function in Caco-2 model. Agah, S; Awika, J; Kim, H; Ravisankar, S; Talcott, S; Wu, C, 2019)	0.72
" Low bioavailability of quercetin has also led researchers to construct various quercetin-involved nanoparticles."	( Application of quercetin in neurological disorders: from nutrition to nanomedicine. Amanzadeh, E; Esmaeili, A; Nourbakhshnia, M; Rahgozar, S, 2019)	1.17
" However, their bioavailability is low."	( Quercetin and its metabolite isorhamnetin promote glucose uptake through different signalling pathways in myotubes. Ashida, H; Croft, K; Jiang, H; Nakamura, A; Yamashita, Y, 2019)	1.96
" This study aimed to examine: (1) the extent to which quercetin altered the starch digestion and the glycemic potential of the fortified western baked bread as well as oriental steamed bread, (2) the matrix effects of bread on the potential bioaccessibility and bioavailability of quercetin."	( In vitro bioaccessibility and bioavailability of quercetin from the quercetin-fortified bread products with reduced glycemic potential. Leong, LP; Lin, J; Teo, LM; Zhou, W, 2019)	1.02
"Glycosylation is a key modification for most molecules including plant natural products, for example, flavonoids and isoflavonoids, and can enhance the bioactivity and bioavailability of the natural products."	( Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP-β-l-rhamnose and rhamnosylation mechanism. Fei, S; Gao, Y; Li, J; Liu, X; Shen, Y; Wang, X; Yang, X; Zong, G, 2019)	0.51
" However, different preclinical and clinical studies have noted significant shortcomings, such as nonspecific tumor targeting and low bioavailability which limit their usage in therapeutics."	( Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy. Chatterjee, S; Das, J; Ghosh, N; Kundu, M; Manna, P; Sadhukhan, P; Sil, PC, 2019)	0.83
" However, QE is poorly soluble in water and slightly soluble in oil, which results in its low oral bioavailability and limits its application in the clinic."	( Size-Dependent Biological Effects of Quercetin Nanocrystals. Gao, J; Liu, Q; Sun, J; Yang, X; Yu, F; Zhang, H; Zheng, A, 2019)	0.79
" Superparamagnetic iron oxide nanoparticle (SPION) is a novel drug delivery system that enhances the bioavailability of quercetin."	( Quercetin conjugated with superparamagnetic iron oxide nanoparticles improves learning and memory better than free quercetin via interacting with proteins involved in LTP. Abadi, REN; Amanzadeh, E; Beheshti, S; Esmaeili, A; Kazemipour, N; Pahlevanneshan, Z, 2019)	2.16
"To investigate the effects of water-soluble dietary fibers (pectin, soybean fiber, and guar gum) on the bioavailability of quercetin glucoside mixture (Q3GM) comprising quercetin-3-O-glucoside (Q3G, 31."	( Water-soluble dietary fibers enhance bioavailability of quercetin and a fiber derived from soybean is most effective after long-term feeding in rats. Hara, H; Hira, T; Mizuta, E; Tanaka, S; Trakooncharoenvit, A, 2020)	1.01
"Water-soluble dietary fibers, especially soybean fiber, enhanced quercetin bioavailability after chronic feeding and may promote beneficial effects of quercetin on disease prevention."	( Water-soluble dietary fibers enhance bioavailability of quercetin and a fiber derived from soybean is most effective after long-term feeding in rats. Hara, H; Hira, T; Mizuta, E; Tanaka, S; Trakooncharoenvit, A, 2020)	1.04
"The poor water solubility and oral bioavailability of many lipophilic polyphenols can be improved through the use of colloidal delivery systems."	( Encapsulation of Lipophilic Polyphenols into Nanoliposomes Using pH-Driven Method: Advantages and Disadvantages. Liu, C; Liu, W; McClements, DJ; Peng, S; Zhou, W; Zou, L, 2019)	0.51
" Finally, the study of theoretical physicochemical properties, the observation of low toxicity (hemolysis assay), and the evaluation of oral bioavailability of the TP derivative showed that it is a possible anti-inflammatory drug candidate."	( Castro, RI; Morales-Quintana, L; Valenzuela-Riffo, F, 2019)	0.51
" Numerous nanoformulations, including solid lipid nanoparticles, polymeric nanoparticles, micelles, and liposomes, have been formulated to enhance the bioavailability and stability, as well as the therapeutic efficacy of polyphenols."	( Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma. Ashby, CR; Chauhan, H; Heenatigala Palliyage, G; Singh, S; Tiwari, AK, 2019)	0.51
"Quercetin possesses various health beneficial functions, but its poor bioavailability limits these functions."	( Enzymatically modified isoquercitrin promotes energy metabolism through activating AMPKα in male C57BL/6 mice. Ashida, H; Croft, KD; Horiuchi, Y; Jiang, H; Yamashita, Y; Yoshioka, Y; Yuan, S, 2019)	1.96
" Glycosylation is a significant method for the structural modification of various flavanols, resulting in glycosides with increased solubility, stability, and bioavailability compared with the corresponding aglycone."	( Natural Product Glycosylation: Biocatalytic Synthesis of Quercetin-3,4'-O-diglucoside. Cai, R; Chen, K; Chen, L; Jia, H; Li, Y; Sun, P; Yan, M, 2020)	0.8
" Also the ability of each classification system to predict and determine the extent of absorption of the Chinese herbal compound was investigated based on the absolute bioavailability of representative components."	( Establishment of modified biopharmaceutics classification system absorption model for oral Traditional Chinese Medicine (Sanye Tablet). Cao, X; Dou, Z; Li, H; Liu, T; Liu, Y; Ren, X; Wang, M, 2019)	0.51
" Nuciferine is the best of the five components, with absolute bioavailability reaching 61."	( Establishment of modified biopharmaceutics classification system absorption model for oral Traditional Chinese Medicine (Sanye Tablet). Cao, X; Dou, Z; Li, H; Liu, T; Liu, Y; Ren, X; Wang, M, 2019)	0.51
"The five representative components (except for nuciferine) are all class III/IV, which correlates well with the absolute bioavailability results and demonstrates that they are poorly absorbed substances."	( Establishment of modified biopharmaceutics classification system absorption model for oral Traditional Chinese Medicine (Sanye Tablet). Cao, X; Dou, Z; Li, H; Liu, T; Liu, Y; Ren, X; Wang, M, 2019)	0.51
" Thus, the relative oral bioavailability of quercetin when administered as casein nanoparticles (close to 37%) was found to be about 9-times higher than the oral solution of the flavonoid in a mixture of PEG 400 and water."	( Casein nanoparticles in combination with 2-hydroxypropyl-β-cyclodextrin improves the oral bioavailability of quercetin. Esparza, I; González-Navarro, CJ; Irache, JM; Larrañeta, E; Morales-Gracia, J; Peñalva, R, 2019)	0.99
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51
" Herein, we prepared a biodegradable super paramagnetic starch-based hydrogel grafted onto fumaric acid for increasing Quer bioavailability and controlling its release."	( Enhancing quercetin bioavailability by super paramagnetic starch-based hydrogel grafted with fumaric acid: An in vitro and in vivo study. Doosti, M; Hosseini, SH; Mousavi, SN; Rasoulifard, MH; Seyed Dorraji, MS, 2019)	0.92
" Naturally available phyto chemicals like piperine and quercetin as well as some floroquinolones are known to inhibit MDR1 and CYP3A37 activity and increases bioavailability of co-administered drugs."	( Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens. Mathapati, BS; Modi, CM; Patel, HB; Patel, UD, 2019)	1.07
" However, for biological applications, the bioavailability of quercetin is low due to physiological barriers."	( Preparation and Characterization of Quercetin-Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability. Barreras-Urbina, CG; Carvajal-Millan, E; Castro-Enríquez, DD; Del-Toro-Sánchez, CL; Javier Cinco-Moroyoqui, F; Juárez, J; López-Ahumada, GA; Rodríguez-Félix, F; Ruiz-Cruz, S; Tapia-Hernández, JA, 2019)	1.03
" This article aims to review the current literature on the bioavailability of quercetin and kaempferol from food sources and evaluate the potential cardiovascular effects in humans."	( Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Dabeek, WM; Marra, MV, 2019)	1.18
" Nonetheless, their low bioavailability forecasts controversy about mechanisms on their in vivo scavenging activity against reactive oxygen species (ROS)."	( Antioxidant effect of phenolic compounds (PC) at different concentrations in IEC-6 cells: A spectroscopic analysis. Alvarez-Parrilla, E; Barraza-Garza, G; Castillo-Michel, H; Cotte, M; de la Rosa, LA; Martinez-Martinez, A; Pérez-León, JA, 2020)	0.56
"We recently showed that quercetin-conjugated iron oxide nanoparticles (QNPs) promoted the bioavailability of quercetin (Qu) in the brain of rats and improved the learning and memory of diabetic rats."	( The antitoxic effects of quercetin and quercetin-conjugated iron oxide nanoparticles (QNPs) against H Esmaeili, A; Ghaedi, K; Rahgozar, S; Yarjanli, Z; Zarrabi, A, 2019)	1.12
" Bulk quercetin has low bioavailability and thus, from obtained data we suggest that LA-Q-ORMOSIL nanoparticles provide high therapeutic value in protecting experimental animals against CP-induced liver injury."	( Lactobionic Acid Conjugated Quercetin Loaded Organically Modified Silica Nanoparticles Mitigates Cyclophosphamide Induced Hepatocytotoxicity. Flora, SJ; Naqvi, S; Sharma, H, 2019)	1.29
" Enzymatically modified isoquercitrin (EMIQ®) has a bioavailability 17-fold higher than quercetin aglycone and has shown potential CVD moderating effects in animal studies."	( Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease. Bondonno, CP; Bondonno, NP; Croft, KD; Hodgson, JM; Ward, NC; Woodman, RJ, 2020)	0.78
" The strategy plays the solubility advantage of INH to improve the bioavailability of the insoluble QCT, thereby significantly enhancing the QCT's hepatoprotective effects."	( A new cocrystal of isoniazid-quercetin with hepatoprotective effect: The design, structure, and in vitro/in vivo performance evaluation. Li, YT; Liu, F; Wang, LY; Wu, ZY; Yan, CW; Yu, MC, 2020)	0.85
" Its bioavailability is, however, low and, therefore, its metabolites could rather be responsible for this effect."	( A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses. Mladěnka, P; Najmanová, I; Pourová, J, 2020)	0.83
"Quercetin, a pigment (flavonoid) found in many plants and foods, has good effects on protecting liver function but poor solubility and bioavailability in vivo."	( Protective and therapeutic effects of nanoliposomal quercetin on acute liver injury in rats. Hu, Y; Liao, M; Liu, L; Liu, X; Pan, Y; Yang, P; Zhang, Y, 2020)	2.25
" The nanoliposomal quercetin showed high bioactivity and bioavailability in rat liver and markedly attenuated the liver index and pathologic changes in injured liver tissue."	( Protective and therapeutic effects of nanoliposomal quercetin on acute liver injury in rats. Hu, Y; Liao, M; Liu, L; Liu, X; Pan, Y; Yang, P; Zhang, Y, 2020)	1.14
"Liposomal nanoparticles may improve the solubility and bioavailability of quercetin in liver."	( Protective and therapeutic effects of nanoliposomal quercetin on acute liver injury in rats. Hu, Y; Liao, M; Liu, L; Liu, X; Pan, Y; Yang, P; Zhang, Y, 2020)	1.04
" These molecules have poor bioavailability that may remain as the limiting factor in their clinical effects."	( Natural polyphenols in preclinical models of epilepsy. Dhir, A, 2020)	0.56
"05) antioxidant activity of consumers' blood compared to control bread consumption, indicating good bioavailability of flavonols."	( Thermal stability and bioavailability of bioactive compounds after baking of bread enriched with different onion by-products. Bedrníček, J; Jirotková, D; Kadlec, J; Laknerová, I; Samková, E; Smetana, P; Tříska, J; Vrchotová, N, 2020)	0.56
"In this study, whey protein isolate (WPI)-quercetin (Que)-lotus root amylopectin (LRA) hydrogels (WPI-QUE-LRA) was developed to improve the solubility, stability and bioavailability of quercetin."	( The hydrogel of whey protein isolate coated by lotus root amylopectin enhance the stability and bioavailability of quercetin. Li, QM; Liu, K; Luo, JP; Pan, LH; Shen, WD; Zha, XQ, 2020)	1.03
" However, the hydrophobic nature, poor bioavailability and low cellular uptake of most natural agents limit their therapeutic effectiveness."	( Efficient synergistic combination effect of Quercetin with Curcumin on breast cancer cell apoptosis through their loading into Apo ferritin cavity. Alberti, D; Bitonto, V; Geninatti Crich, S; Khoee, S; Mansourizadeh, F; Sepehri, H; Tripepi, M, 2020)	0.82
" Apart from the promising therapeutic activities of QT molecule, their applications have been limited due to some major concerns, including low oral bioavailability and poor aqueous solubility."	( Recent Advances in Liposomal Drug Delivery System of Quercetin for Cancer Targeting: A Mechanistic Approach. Alshehri, S; Altamimi, MA; Das, SS; Hussain, A; Imam, SS; Singh, SK; Verma, PRP, 2020)	0.81
"We evaluated if chronic consumption of quercetin (Q) with green tea extract (GTE) enhances the bioavailability of GT polyphenols (GTPs) and reduces methylation activity as previously observed in mouse xenograft tumors."	( Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer. Aronson, WJ; Grogan, T; Grojean, EM; Heber, D; Henning, SM; Hsu, M; Husari, G; Lee, RP; Li, Z; Ly, A; Trang, A; Wang, P; Yang, J, 2020)	1.04
" Our results showed that Exo-Que improved brain targeting of Que as well as significantly enhanced bioavailability of Que."	( Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles. Guo, L; Jiang, Y; Qi, Y; Shi, Y; Sui, H; Zhao, L, 2020)	0.89
" In conclusion, the results showed that quercetin supplementation increased the bioavailability of NO in the jejunum in euglycemic and mitigate the effects of diabetes on nNOS-IR neurons and VIP-IR varicosities in the myenteric plexus of diabetic rats."	( Quercetin increases bioavailability of nitric oxide in the jejunum of euglycemic and diabetic rats and induces neuronal plasticity in the myenteric plexus. Armani, ALC; Barili, E; Bossolani, GDP; Cecchini, R; de Souza Melo, CG; de Souza Neto, FP; de Souza, SRG; Frez, FCV; Guarnier, FA; Martins-Perles, JVC; Zanoni, JN; Zignani, I, 2020)	2.27
" Besides, considering the low bioavailability of quercetin, great efforts have been made in its drug delivery systems to address the problem of limited application."	( Drug delivery based pharmacological enhancement and current insights of quercetin with therapeutic potential against oral diseases. Li, C; Sun, J; Sun, Y; Tao, B; Wan, Y; Wang, L; Wang, Y, 2020)	1.04
" The low bioavailability and poor solubility of QT have also led researchers to make various QT-involved nanoparticles (NPs) to overcome these limitations."	( Crosstalk between obesity, diabetes, and alzheimer's disease: Introducing quercetin as an effective triple herbal medicine. Ebrahimpour, S; Esmaeili, A; Zakeri, M, 2020)	0.79
"Numerous studies document an increased production of reactive oxygen species (ROS) with a subsequent decrease in nitric oxide (NO) bioavailability in different cardiovascular diseases, including hypertension, atherosclerosis, and heart failure."	( Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System. Cebova, M; Dayar, E; Pechanova, O, 2020)	0.56
" Recent strategies in drug delivery significantly contribute to overcoming the low bioavailability of flavonoids."	( Antiviral Properties of Flavonoids and Delivery Strategies. Antonelli, A; Magnani, M; Ninfali, P; Scarpa, ES, 2020)	0.56
" Due to its low bioavailability and poor water solubility, quercetin has limitations in clinical application."	( [Research progress on antitumor activity of quercetin derivatives]. Feng, YL; Lu, LP; Zhai, GY, 2020)	1.06
" Que's oral bioavailability is limited by its low water solubility and extended peripheral metabolism; thus, nasal administration may be a promising alternative to achieve effective Que concentrations in the brain."	( Preparation and Biophysical Characterization of Quercetin Inclusion Complexes with β-Cyclodextrin Derivatives to be Formulated as Possible Nose-to-Brain Quercetin Delivery Systems. Andreadelis, I; Athanasiadou, I; Banella, S; Chatziathanasiadou, MV; Chountoulesi, M; Colombo, G; Dallas, P; Demetzos, C; Diamantis, DA; Javornik, U; Manta, K; Mavromoustakos, T; Moschovou, K; Naziris, N; Papakyriakopoulou, P; Plavec, J; Rekkas, DM; Spaneas, D; Tzakos, AG; Vakali, V; Valsami, G, 2020)	0.81
" The likely antiviral properties of quercetin are anyway challenged by its very poor oral bioavailability profile and any attempt to overcome this limit should be welcome."	( Quercetin Phytosome® as a potential candidate for managing COVID-19. Bertuccioli, A; Derosa, G; Devrajani, BR; DI Pierro, F; Khan, A; Khan, BA; Khan, S; Maffioli, P; Nigar, R; Ujjan, I, 2021)	2.34
" Guided by the increased bioavailability of quercetin in its encapsulated form, further evaluation of the biological activity of the magnetic as well as non-magnetic core-shell nanoparticles, pertaining to their anti-amyloid and antioxidant potential, revealed interference with the aggregation of β-amyloid peptide (Aβ) in Alzheimer's disease, reduction of Aβ cellular toxicity and minimization of Aβ-induced Reactive Oxygen Species (ROS) generation."	( Modified magnetic core-shell mesoporous silica nano-formulations with encapsulated quercetin exhibit anti-amyloid and antioxidant activity. Boukos, N; Halevas, E; Litsardakis, G; Mavroidi, B; Nday, CM; Pelecanou, M; Salifoglou, A; Smith, GC; Tang, J, 2020)	1.04
" The purpose of the present study was to propose a drug delivery system to enhance the oral bioavailability of combined quercetin and resveratrol."	( Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System. Chusri, S; Jaisamut, P; Limsuwan, S; Wanna, S; Wiwattanapatapee, R; Wiwattanawongsa, K, 2021)	1.06
" However, its bioavailability is poor due to the low absorption and P-gp efflux."	( Natural P-gp inhibitor EGCG improves the acteoside absorption in Caco-2 cell monolayers and increases the oral bioavailability of acteoside in rats. Chen, Q; Huang, W; Liu, X; Lu, B; Peng, J; Wu, L; Xu, T; Zhou, F, 2020)	0.56
" In addition, studies on the bioavailability of quercetin and its capacity to cross the blood-brain barrier and how this capacity and bioavailability can be increased were given."	( Cholinesterase Inhibitory Potential of Quercetin towards Alzheimer's Disease - A Promising Natural Molecule or Fashion of the Day? - A Narrowed Review. Orhan, IE, 2021)	1.15
" Previous treatments existed some limitations of poor bioavailability and targeting the efficiency of drugs."	( Glycyrrhizin mediated liver-targeted alginate nanogels delivers quercetin to relieve acute liver failure. Cui, YL; Wang, GF; Wang, QS; Xu, D; Zhang, HY; Zhao, FQ, 2021)	0.86
" Nanoparticles have been applied for the delivery of quercetin, enhancing its bioavailability and efficacy in the alleviation of I/R injury."	( Quercetin in Attenuation of Ischemic/Reperfusion Injury: A Review. Ashrafizadeh, M; Entezari, M; Esmaeili, H; Hushmandi, K; Najafi, M; Raei, M; Saleki, H; Samarghandian, S; Shahinozzaman, M; Zabolian, A; Zarrabi, A, 2021)	2.31
"Quercetin-loaded microcapsules (QLM) promote controlled release and higher bioavailability of quercetin, an antioxidant and neuroprotective agent."	( Protective effects of quercetin-loaded microcapsules on the enteric nervous system of diabetic rats. Baracat, MM; Blegniski, FP; Bossolani, GDP; Guarnier, FA; Hermes-Uliana, C; Lima, MM; Martins, HA; Perles, JVCM; Sehaber-Sierakowski, CC; Vieira-Frez, FC; Zanoni, JN, 2021)	2.38
"Based on oral bioavailability and drug-likeness, the main active components of Simiao powder were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP)."	( Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Simiao Powder on Knee Osteoarthritis. Huang, Z; Li, X; Mao, J; Shi, X; Wang, P; Wu, P; Xing, R; Zhang, L; Zhang, N, 2020)	0.56
" The increase in the bioavailability can be obtained with nanostructures."	( Anti-MDR Effects of Quercetin and its Nanoemulsion in Multidrug-Resistant Human Leukemia Cells. Araújo, GS; Cañedo, AD; Carrett-Dias, M; da Silva Alves, B; da Silva Júnior, FMR; de Oliveira, BS; de Souza Votto, AP; Dora, CL; Fernandes E Silva, E; Filgueira, DMVB; Machado, AP; Marques, MB; Santos, PA, 2021)	0.94
" PPs have structural diversity which impacts their bioavailability as they accumulate in the large intestine and are extensively metabolized through gut microbiota (GM)."	( Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota. Chelliah, R; Daliri, EB; Javed, A; Oh, DH; Rubab, M; Shabbir, U, 2021)	1.02
" The aim of this work was to study, in rats, the bioavailability and nephroprotective efficacy of a micellar formulation of Pluronic F127-encapsulated quercetin (P-quercetin), with improved hydrosolubility."	( A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity. Casanova, AG; Colino, CI; de Paz, E; Gutiérrez-Millán, C; López-Hernández, FJ; Martín, Á; Morales, AI; Prieto, M; Ruszkowska-Ciastek, B, 2021)	1.12
" In addition, a network pharmacology approach, including bioactive compounds, was used with oral bioavailability (OB) and drug-likeness (DL) evaluation."	( Uncovering the Key miRNAs and Targets of the Liuwei Dihuang Pill in Diabetic Nephropathy-Related Osteoporosis based on Weighted Gene Co-Expression Network and Network Pharmacology Analysis. Cheng, J; Geng, R; Hua, Z; Huang, GC; Liu, MM; Lv, NN; Ma, Y; Xu, HY, 2022)	0.72
" Poor solubility and low bioavailability of Q as a bioflavonoid with potent antioxidant activity, limit its therapeutic application."	( Quercetin-loaded F127 nanomicelles: Antioxidant activity and protection against renal injury induced by gentamicin in rats. Beyzaei, H; Bilal, M; Hasanein, P; Kyzas, GZ; Rahdar, A, 2021)	2.06
" Moreover, in order to enhance quercetin bioavailability and capacity to target the brain, we discuss an innovative drug delivery system."	( The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases. Benameur, T; Porro, C; Soleti, R, 2021)	1.15
"This study examined the effects of a combination of soybean fiber and α-glycosyl-isoquercitrin (AGIQ) on improving quercetin bioavailability and glucose metabolism in rats fed an obesogenic diet."	( Combination of α-Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide-1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet. Hara, H; Hira, T; Trakooncharoenvit, A, 2021)	1.07
" However, the oral bioavailability of nutraceuticals encapsulated in Pickering emulsions was not well established."	( Bioavailability of quercetin in zein-based colloidal particles-stabilized Pickering emulsions investigated by the in vitro digestion coupled with Caco-2 cell monolayer model. Huang, XN; Ma, JJ; Yang, XQ; Yin, SW; Yu, YG, 2021)	0.95
" In this work, novel cocrystals, consisting of two antithrombotic drugs with poor solubility and low bioavailability in vivo, namely, apixaban (Apx) and quercetin (Que), were developed to discover a potential method to improve the poor solubility and internal absorption of the drug combination."	( Cocrystal of Apixaban-Quercetin: Improving Solubility and Bioavailability of Drug Combination of Two Poorly Soluble Drugs. Du, G; Jiao, L; Kong, D; Lu, Y; Song, J; Wang, H; Yang, D; Yang, H; Yang, S; Zhang, L; Zhao, X, 2021)	1.13
" Besides the natural food resources that may provide Quercetin, the interest in delivery systems that could enhance its bioavailability in the human body has seen growth in recent years."	( Solid Lipid Nanoparticles Produced via a Coacervation Method as Promising Carriers for Controlled Release of Quercetin. Consumi, M; Leone, G; Magnani, A; Talarico, L; Tamasi, G, 2021)	1.08
" Moreover, the implications of digestion on the putative benefits of dietary PC against COVID-19 are presented by addressing the bioavailability and biotransformation of PC by the gut microbiota."	( Bioactivity, bioavailability, and gut microbiota transformations of dietary phenolic compounds: implications for COVID-19. Augusti, PR; Bronze, MR; Conterato, GMM; Denardin, CC; Emanuelli, T; Prazeres, ID; Serra, AT, 2021)	0.62
"Flavonoid bioavailability and bioactivity is associated with interindividual variability, which is partially due to differences in health status."	( Intracellular quercetin accumulation and its impact on mitochondrial dysfunction in intestinal Caco-2 cells. Boon, N; Criel, H; De Schutter, K; Goeminne, G; Grootaert, C; Raes, K; Rajkovic, A; Smagghe, G; Van Camp, J; Vissenaekens, H, 2021)	0.98
"Quercetin-loaded nanosuspensions (Que-NSps) added metabolic inhibitors were evaluated as drug delivery system to promote the oral bioavailability of quercetin."	( Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions. Ao, H; Fu, J; Li, H; Li, M; Wang, W; Wang, X, 2021)	2.33
" Problems like poor solubility, bioavailability and stability, short half-life and weak tumor-targeting biodistribution make quercetin an unreliable candidate for cancer therapy."	( Quercetin nanoformulations: a promising strategy for tumor therapy. Chen, X; Cheng, M; Zang, X; Zhang, X, 2021)	2.27
"Hyperoside (HYP) has various potential benefits, however, its low water-solubility and poor bioavailability have restricted its application."	( Fabrication and characterization of zein-tea polyphenols-pectin ternary complex nanoparticles as an effective hyperoside delivery system: Formation mechanism, physicochemical stability, and in vitro release property. Jin, Y; Li, F; Li, M; Liu, F; Lou, X; Peng, F; Wang, J; Wang, X; Xu, H, 2021)	0.62
"Ticagrelor is a first-line clinical drug for the treatment of acute coronary syndrome, but its oral bioavailability is relatively low."	( Untargeted metabolomics reveals the mechanism of quercetin enhancing the bioavailability of ticagrelor. Sun, Y; Tang, Y; Wei, B; Wei, S; Xu, X; Zhang, W, 2021)	0.88
" The discrepancy between the in vitro and in vivo studies was probably due to a poor bioavailability of flavonoids in the intestine."	( Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration. Chen, ZY; Hao, W; He, WS; He, Z; Kwek, E; Li, YM; Liang, N; Liu, J; Ma, KY; Zhao, Y; Zhu, H, 2021)	1.02
" Despite the good characteristics of quercetin, like many flavonoids, it is characterized by reduced bioavailability due to limited absorption."	( Substantiation of attention around antioxidants of plant origin for use in complex pharmacotherapy of diseases of the oral cavity. Chornij, N; Kritsak, M; Pavliuk, B; Prokopovych, O; Stechyshyn, I, 2021)	0.89
" Moreover, another important issue that needs to be resolved in future research is to improve the bioavailability of quercetin."	( The Therapeutic Effects and Mechanisms of Quercetin on Metabolic Diseases: Pharmacological Data and Clinical Evidence. Du, L; Fan, G; Kuang, T; Peng, H; Wu, X; Xu, X; Yi, H; Zhang, J, 2021)	1.09
" Besides, due to the low bioavailability of QUR innovative drug delivery strategies (QUR loaded gel, QUR polymeric micelle, QUR nanoparticles, glucan-QUR conjugate, and QUR loaded mucoadhesive nanoemulsions) have been proposed to improve its bioavailability and providing novel therapeutic approaches."	( Novel extraction, rapid assessment and bioavailability improvement of quercetin: A review. Aadil, RM; Hussain, A; Khan, S; Manzoor, MF; Sahar, A; Sameen, A; Siddique, R; Xu, B, 2021)	0.86
" Two lipophilic drugs, curcumin and quercetin were used in this study due to their dissolution rate limited oral bioavailability and poor permeability."	( Development of mushroom polysaccharide and probiotics based solid self-nanoemulsifying drug delivery system loaded with curcumin and quercetin to improve their dissolution rate and permeability: State of the art. Chellappan, DK; Dua, K; Gowthamarajan, K; Gulati, M; Gupta, G; Gupta, PK; Jain, SK; Jha, NK; Kapoor, B; Khursheed, R; Singh, SK; Wadhwa, S; Zacconi, F, 2021)	1.1
" A marked cell bioavailability increase was demonstrated for the artemetin C-prenylated derivative."	( Effects of quercetin and artemetin prenylation on bioavailability and bioactivity. Bombardelli, E; Khalili, A; Nieddu, M; Pollastro, F; Rosa, A; Salamone, S; Sansaro, A, 2021)	1.01
" This study aimed to explore the potential of the quercetin (QUR) loaded magnetic nano-micelles for improving drug bioavailability while reducing the drug adverse effects."	( Self-assembled magnetic polymeric micelles for delivery of quercetin: Toxicity evaluation on isolated rat liver mitochondria. Hosseini, MJ; Kermanian, M; Rahmati, MA; Rashidzadeh, H; Sadighian, S, 2022)	1.22
" However, the hindrances in their absorption, specificity, and bioavailability can be overcome using nanotechnology."	( Nanoencapsulation of Polyphenols as Drugs and Supplements for Enhancing Therapeutic Profile - A Review. Ansari, MT; Hafiz, AK; Hasnain, MS; Kalam, N; Khatoon, S; Shaikh, MF, 2022)	0.72
", Quercetin (QUR) for improving the bioavailability of the SEL in the brain via the oral route."	( Lipid nanocarrier of selegiline augmented anti-Parkinson's effect via P-gp modulation using quercetin. Ali, A; Ali, J; Ashhar, MU; Baboota, S; Qamar, Z; Qizilibash, FF; Sahoo, PK, 2021)	1.56
", curcumin and quercetin), at specific concentrations, in dosage forms could improve the bioavailability of the BCS Class III and IV drugs that are substrates of CYP3A4 and p-glycoprotein."	( Determination of effective concentrations of drug absorption enhancers using in vitro and ex vivo models. Enslin, GM; Kheoane, PS; Tarirai, C, 2021)	0.97
" However, poor solubility and low bioavailability of QC have also led researchers to make various QC-involved nanoparticles to overcome these limitations."	( Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles. Bardestani, A; Ebrahimpour, S; Esmaeili, A, 2021)	2.06
" The bioavailability of EGCG was higher in the hydrogel beads than those in the double emulsions, while the quercetin bioavailability was not significantly different expect for the ratio of 3:7."	( Co-encapsulation of (-)-epigallocatechin-3-gallate and quercetin in double emulsion hydrogel beads: Microstructures, functional properties, and digestion behaviors. Du, X; Hu, M; Li, Y; Liu, G; Qi, B; Zhang, W, 2022)	1.18
" However, it is poorly absorbed in the upper gastrointestinal tract during oral intake but rather is metabolized by the intestinal microbiota into various phenolic acids."	( 3-(3-Hydroxyphenyl)propionic acid, a microbial metabolite of quercetin, inhibits monocyte binding to endothelial cells via modulating E-selectin expression. Feng, J; Ge, C; Li, R; Li, W, 2022)	0.96
"57-folds increase in bioavailability was observed for curcumin and quercetin respectively, upon loading into SNEDDS pellets."	( Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin induced rats. A, A; Awasthi, A; Chitranshi, N; Corrie, L; Dua, K; Gulati, M; Gupta, PK; Jha, NK; K R, A; Kaur, J; Khursheed, R; Kumar, A; Kumar, B; Kumar, R; Mustafa, G; Singh, SK; Vishwas, S; Wadhwa, S; Zacconi, F, 2022)	1.21
" However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin."	( Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy. Dhanya, R, 2022)	2.38
" However, the low solubility and poor bioavailability of quercetin have limited its applications; therefore, the researchers have tried to design and synthesize many new derivatives of quercetin through different strategies to modify quercetin restrictions and improve its biological activities."	( O-Glycoside quercetin derivatives: Biological activities, mechanisms of action, and structure-activity relationship for drug design, a review. Alizadeh, SR; Ebrahimzadeh, MA, 2022)	1.35
" However, quercetin's low solubility and poor bioavailability have restricted its applicability; as a result, researchers have attempted to design and synthesize numerous novel quercetin derivatives using various methodologies in order to modify quercetin's constraints; the physico-chemical properties of quercetin's molecular scaffold make it appealing for drug development; low molecular mass and chemical groups are two of these characteristics."	( Quercetin derivatives: Drug design, development, and biological activities, a review. Alizadeh, SR; Ebrahimzadeh, MA, 2022)	2.57
" This study provides a new strategy for designing quercetin-loaded nanoparticles based on natural polysaccharides to improve the bioavailability of quercetin."	( Hohenbuehelia serotina polysaccharides self-assembled nanoparticles for delivery of quercetin and their anti-proliferative activities during gastrointestinal digestion in vitro. Feng, R; Li, X; Luo, Z; Wang, L; Zhou, P, 2022)	1.2
"Although quercetin (Que) has many beneficial therapeutic effects on the human body, its oral bioavailability is poor because of its low water solubility."	( Enhanced water dispersibility and Caco-2 cell monolayer permeability of quercetin by complexation with casein hydrolysate. Inada, A; Oshima, T; Sawao, A; Takahashi, K, 2022)	1.37
" In normal and DMH-induced rats, a pharmacokinetic study demonstrated that polyherbal nanoparticles had a typical sustained release profile with a fourfold increase in bioavailability when compared to polyherbal extract."	( Improving gallic acid and quercetin bioavailability by polymeric nanoparticle formulation. Killedar, S; Patil, P, 2021)	0.92
"Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal injection, but its low bioavailability curtails its prospective clinical utility in oral therapy."	( Protective Effect of Quercetin 3- Casanova, AG; González-Paramás, AM; López-Hernández, FJ; Martín, Á; Morales, AI; Muñoz-Reyes, D; Prieto, M; Santos-Buelga, C, 2022)	2.48
" However, the poor gastrointestinal absorption and low bioavailability of quercetin curtail its clinical applications."	( Research Progress of Quercetin Delivery Systems. Deng, Y; Li, Y; Liao, L; Peng, C; Xue, X; Zhao, X; Zhou, M, 2022)	1.27
"The bioavailability of quercetin can be improved through the application of delivery systems technologies, such as microparticle delivery systems, solid dispersions, encapsulation, phospholipid complexes, and hydrogels."	( Research Progress of Quercetin Delivery Systems. Deng, Y; Li, Y; Liao, L; Peng, C; Xue, X; Zhao, X; Zhou, M, 2022)	1.35
"Quercetin (QUE)-loaded poly(lipoic acid) nanoparticles (QUE/pLA) were developed to improve chemical stability in the gastrointestinal (GI) tract, oral bioavailability (BA), and pharmacological properties of QUE."	( Development of Poly(lipoic acid) Nanoparticles with Improved Oral Bioavailability and Hepatoprotective Effects of Quercetin. Banik, S; Onoue, S; Sato, H; Yamada, K, 2022)	2.37
" However, low water solubility and bioavailability are the limitations of quercetin for its clinical applications."	( Therapeutic effect of quercetin polymeric nanoparticles on ischemia/reperfusion-induced acute kidney injury in mice. Chang, Y; Chiang, CK; Ho, FM; Huang, KT; Liu, SH; Wu, CT, 2022)	1.27
" Antioxidants' bioavailability has become one of the main research topics in bio-nanomedicine."	( Plant-Derived Nanoscale-Encapsulated Antioxidants for Oral and Topical Uses: A Brief Review. Kim, SH; Lee, YC, 2022)	0.72
"To improve the water solubility, stability and bioavailability of quercetin, the quercetin (Que)-quinoa protein (QP)-lotus root amylopectin (LRA) nanomicelles (Que-QP-LRA) were constructed via self-assembly in the present study."	( The nanomicelles consisting of lotus root amylopectin and quinoa protein: Construction and encapsulation for quercetin. Li, QM; Liu, K; Luo, JP; Pan, LH; Zha, XQ; Zhang, HL, 2022)	1.17
" This limitation was solved by developing a nanoparticles formulation that improves the solubility and bioavailability of several bioactive compounds."	( Nanoparticles Formulation Improves the Antifibrogenic Effect of Quercetin on an Adenine-Induced Model of Chronic Kidney Disease. Bastidas-Ramírez, BE; Gasca-Lozano, LE; Gurrola-Díaz, CM; Hernández-Ortega, LD; Martínez-Limón, FJ; Mena-Enríquez, M; Salazar-Montes, AM; Sánchez-Jaramillo, EA; Vargas-Guerrero, B; Vera-Cruz, JM, 2022)	0.96
" Therefore, to overcome these challenges, an inhalable quercetin-alginate nanogel (QU-Nanogel) was fabricated, and by this special "material-drug" structure, the solubility and bioavailability of quercetin were significantly enhanced, which could further increase the activity of quercetin and provide a promising therapy for ALI."	( A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury. Chen, YB; Cui, YL; Kaur, P; Wang, YL; Yang, BG; Ye, L; Zhang, YB; Zhu, Y, 2022)	1.3
" Therefore, it is important to urgently find a method to improve the oral bioavailability of TAX."	( Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway. Chen, K; Ding, C; Ding, Q; Liu, S; Liu, W; Liu, X; Sun, S; Zhang, J; Zhang, Y; Zhao, Y, 2022)	0.72
"Herein, we designed novel glycocholic acid (GCA)-functionalized double layer nanoparticles (GCA-NPs), which can act via an endogenous pathway and in a temporally controlled manner in the intestine, to enhance the oral bioavailability of hydrophobic chemotherapeutic drugs such as paclitaxel (PTX)."	( Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs. Chen, L; Gao, Z; Han, Y; Huang, W; Jin, J; Jin, M; Liu, C; Liu, W; Liu, Y; Xin, X; Zhang, X, 2022)	0.72
" Besides, quercetin could serve as a prodrug, and the bioavailability of quercetin is improved through chemical modifications or the utilization of effective drug delivery systems."	( Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease. Li, JY; Lyu, YL; Sun, F; Wang, FX; Yang, J; Zhou, HF, 2022)	1.37
" Driven by the need to enhance quercetin bioavailability and bioactivity through metal ion complexation, synthetic efforts led to a unique ternary Ce(III)-quercetin-(1,10-phenanthroline) (1) compound."	( A unique ternary Ce(III)-quercetin-phenanthroline assembly with antioxidant and anti-inflammatory properties. Geromichalou, E; Halevas, E; Hatzidimitriou, A; Katsipis, G; Litsardakis, G; Matsia, S; Pantazaki, A; Papadopoulos, TA; Salifoglou, A, 2022)	1.31
" In this review, we have discussed the approaches of improving solubilization and bioavailability of QCT with the use of nanoformulations."	( Advances on nanoformulation approaches for delivering plant-derived antioxidants: A case of quercetin. Arya, S; Bahadur, P; Kanike, S; Rathod, S; Shah, SA; Tiwari, S, 2022)	0.94
" However, due to its low solubility its bioavailability is limited."	( Comparative Interaction Studies of Quercetin with 2-Hydroxyl-propyl-β-cyclodextrin and 2,6-Methylated-β-cyclodextrin. Cournia, Z; Diamantis, DA; Georgiou, N; Javornik, U; Mauromoustakos, T; Papadourakis, M; Papakyriakopoulou, P; Plavec, J; Tzakos, AG; Tzeli, D; Vakali, V; Valsami, G; Zoupanou, N, 2022)	1
"Flavonoids are associated with health benefits, but most of them have poor oral bioavailability due to their extremely low aqueous solubility."	( Discovery of a novel phosphotransferase from Bacillus subtilis that phosphorylates a broad spectrum of flavonoids. Chang, CF; Hsu, C; Su, NW; Tsai, HY; Yang, CC, 2023)	0.91
" Combined meals of sweet potato and onion may lower the bioavailability of onion quercetin glucosides."	( Lowering effect of combined sweet potato and onion intake on plasma quercetin concentration and underlying mechanism involving intestinal β-glucosidase activity. Kawabata, K; Mukai, R; Nayama, C; Nishijima, H; Nuka, E; Okitsu, M; Sogawa, R; Takahashi, M; Terao, J, 2022)	1.18
"The simultaneous improvement of quercetin (QUE) processing stability and bioavailability has always presented a technical challenge during food processing."	( Improving effect of oleic acid-mediated sodium caseinate-based encapsulation in an ultrasound field on the thermal stability and bioaccessibility of quercetin. Guo, Z; Li, J; Liu, Y; Wang, S, 2022)	1.2
"Improving bioavailability of orally delivered drugs is still challenging, as conventional drug delivery systems suffer from non-specific drug delivery in the gastrointestinal (GI) tract and limited drug absorption efficiency."	( Microencapsulation of Ionic Liquid by Interfacial Self-Assembly of Metal-Phenolic Network for Efficient Gastric Absorption of Oral Drug Delivery. Chen, Y; Feng, J; Ge, S; Li, J; Li, K; Shen, L; Xu, W; Yang, X; Zhang, Y; Zhao, Y, 2022)	0.72
" This is due to their antioxidant and anti-inflammatory properties, despite their low bioavailability which often limits their use in clinical practice."	( Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration. Ceruti, S; Magni, G; Petroni, K; Riboldi, B, 2022)	0.72
" Quercetin (QUE), a bioflavonoid, may modify the bioavailability of drugs used concurrently by inhibiting CYP3A4, CYP2C8, CYP2C9, CYP1A2, and Pglycoprotein (P-gp)."	( Influence of Quercetin Pretreatment on Pharmacokinetics of Warfarin in Rats. Afzal, H; Ahmad, E; Bano, S; Bukhari, NI; Ismail, MA; Jahangir, M; Shamim, R, 2023)	2.19
"Intravenous route of drug administration has maximum bioavailability, which shows 100% of the drug reaches blood circulation, whereas the oral administration of drugs, are readily undergoing pre-systemic metabolism, which means the poor bioavailability of the drug and limited amount of drug reaches the target site."	( A Recent Review on Bio-availability Enhancement of Poorly Water-soluble Drugs by using Bioenhancer and Nanoparticulate Drug Delivery System. Kumar, A; Kumar, D; Kumar, M; Kumar, S; Mandal, UK, 2022)	0.72
"Bioenhancers are substances having medicinal entities which enhance the bioavailability and efficacy of the active constituents of drugs."	( A Recent Review on Bio-availability Enhancement of Poorly Water-soluble Drugs by using Bioenhancer and Nanoparticulate Drug Delivery System. Kumar, A; Kumar, D; Kumar, M; Kumar, S; Mandal, UK, 2022)	0.72
"Bioenhancers are crucial to amplifying the bioavailability of many synthetic drugs."	( A Recent Review on Bio-availability Enhancement of Poorly Water-soluble Drugs by using Bioenhancer and Nanoparticulate Drug Delivery System. Kumar, A; Kumar, D; Kumar, M; Kumar, S; Mandal, UK, 2022)	0.72
" The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types."	( Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin. Avram, A; Barbu, I; Mocanu, A; Pop, LC; Racz, CP; Racz, LZ; Roman, I; Sárközi, M; Toma, VA; Tomoaia, G; Tomoaia-Cotisel, M, 2022)	0.72
" However, quercetin has low bioavailability due to poor water solubility, low absorption, and rapid excretion from the body."	( Anti-Inflammatory, Antioxidative, and Nitric Oxide-Scavenging Activities of a Quercetin Nanosuspension with Polyethylene Glycol in LPS-Induced RAW 264.7 Macrophages. Do, GS; Kang, SG; Kwon, JB; Lee, GB; Oh, SY; Singh, M; Vinayagam, R; Yang, SJ, 2022)	1.35
" Quercetin's bioavailability may limit its use clinically, however."	( Quercetin's Effects on Glutamate Cytotoxicity. Lenard, NR; Riche, K, 2022)	3.07
" However, low bioavailability and potential side effects of senolytics restrict clinical application."	( Bone-targeted delivery of senolytics to eliminate senescent cells increases bone formation in senile osteoporosis. Gao, X; Huang, H; Li, M; Liang, C; Liao, L; Ma, S; Tan, L; Tang, Q; Tian, W; Xing, X; Xu, X; Yang, J; Zou, J, 2023)	0.91
" The review includes a characterization of the mechanism of action of flavonoids, as well as insight into the physicochemical parameters determining their bioavailability in vitro."	( Why Do Dietary Flavonoids Have a Promising Effect as Enhancers of Anthracyclines? Hydroxyl Substituents, Bioavailability and Biological Activity. Golonko, A; Lewandowski, W; Olichwier, AJ; Swislocka, R; Szczerbinski, L, 2022)	0.72
" These findings indicated that QNP due to its high bioavailability was more effective than quercetin can be reduced autistic-like behavior, oxidative and apoptotic damages in the model of MS rats."	( Preventive effect of quercetin-Loaded nanophytosome against autistic-like damage in maternal separation model: The possible role of Caspase-3, Bax/Bcl-2 and Nrf2. Eslami, A; Hasantabar, V; Jelodar, SK; Moghaddam, AH; Ranjbar, M, 2023)	1.45
" Quercetin may be of benefit in COVID-19 patients, especially if administered in its phytosome formulation which greatly enhances its bioavailability but large-scale RCTs are needed to confirm these findings."	( Quercetin for the treatment of COVID-19 patients: A systematic review and meta-analysis. Awan, RU; Cheema, HA; Chinnam, S; Fatima, A; Nashwan, AJ; Shahid, A; Shahzil, M; Sohail, A; Ur Rehman, ME, 2023)	3.26
" Here, we investigated the beneficial role of QUE and its derivative Q2, which demonstrates improved bioavailability and chemical stability, in cardiac lipotoxicity."	( Quercetin and Its Derivative Counteract Palmitate-Dependent Lipotoxicity by Inhibiting Oxidative Stress and Inflammation in Cardiomyocytes. Angelone, T; Ceramella, J; De Bartolo, A; Granieri, MC; Macchia, PE; Mariconda, A; Nettore, IC; Rago, V; Rocca, C; Romeo, N; Sinicropi, MS; Ungaro, P, 2023)	2.35
" The therapeutic properties of quercetin include antioxidant, antibacterial and anti-cancer potential, but its therapeutic value is limited by its hydrophobic nature, low bioavailability and fast metabolism."	( Improvement of Therapeutic Value of Quercetin with Chitosan Nanoparticle Delivery Systems and Potential Applications. Lawson, MK, 2023)	1.47
" These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food."	( Physicochemical stability, antioxidant activity, and antimicrobial activity of quercetin-loaded zein nanoparticles coated with dextrin-modified anionic polysaccharides. Chen, L; Hu, Y; Ji, H; Jiao, A; Jin, Z; Julian McClements, D; Li, X; Lin, Q; Long, J; Qiu, C; Sang, S; Xu, X; Zhang, Z, 2023)	1.33
" This review also emphasizes the significance of the co-delivery vehicles-based nanoparticles of such bioactive phytochemicals that could improve their bioavailability and reduce their systemic dose."	( Co-administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets. Asoodeh, A; Ghobadi, N, 2023)	0.91
" The components of AM were analyzed using the Traditional Chinese Medicine System Pharmacology (TCMSP) database to screen the active ingredients of AM based on their oral bioavailability and drug similarity index."	( Anticancer Effect of Active Component of Astragalus Membranaceus Combined with Olaparib on Ovarian Cancer Predicted by Network-Based Pharmacology. Guo, Z; Jiang, J; Lang, F; Li, J; Liu, Y, 2023)	0.91
" However, the low bioavailability of quercetin and the presence of the BBB structure limit the therapeutic efficacy."	( Protective effects of dietary quercetin on cerebral ischemic injury: pharmacology, pharmacokinetics and bioavailability-enhancing nanoformulations. Fu, K; Gong, L; Li, Y; Ma, C; Peng, C; Wang, C; Xue, X; Zhang, Y; Zhou, H, 2023)	1.47
"The synergistic effect of epigallocatechin-3-gallate (E) and quercetin (Q) enhances the therapeutic efficacy on related diseases; however, the instability and lower bioavailability of E and Q limited their application."	( The synergistic effect of epigallocatechin-3-gallate and quercetin co-loaded hydrogel beads on inflammatory bowel disease. Du, X; Hu, M; Huang, Y; Li, Y; Liu, G; Qi, B, 2023)	1.4
"An inclusion complex formation with cyclodextrin is a promising method to improve the bioavailability of water-insoluble drugs."	( Pharmacokinetic studies of hyperoside-2-hydroxypropyl-β-cyclodextrin inclusion complex and ameliorated DSS-induced colitis in mice. Cao, S; Chu, X; Ding, Y; Fu, X; Li, X; Li, Y; Liu, C; Su, J; Wang, X; Xue, J; Zhang, R; Zhang, X, 2023)	0.91
" However, the physicochemical properties, such as solubility and permeability, of this compound are low, which ultimately limits its bioavailability on the target site."	( The significance of quercetin-loaded advanced nanoformulations for the management of diabetic wounds. Chaudhary, A; Imran, M; Mohammed, Y; Panthi, VK; Paudel, KR, 2023)	1.23
" Quercetin (QC) has been shown to affect CSC viability, but its low bioavailability limits its clinical use."	( Effective inhibition of breast cancer stem cell properties by quercetin-loaded solid lipid nanoparticles via reduction of Smad2/Smad3 phosphorylation and β-catenin signaling pathway in triple-negative breast cancer. Hatami, M; Kheirollah, A; Khorsandi, L; Kouchak, M; Rashidi, M, 2023)	2.06
"Our findings demonstrate that SLNs improve the cytotoxic effect of QC in MDA-MB231 cells by increasing its bioavailability and inhibiting epithelial-mesenchymal transition (EMT), thereby effectively inhibiting CSC generation."	( Effective inhibition of breast cancer stem cell properties by quercetin-loaded solid lipid nanoparticles via reduction of Smad2/Smad3 phosphorylation and β-catenin signaling pathway in triple-negative breast cancer. Hatami, M; Kheirollah, A; Khorsandi, L; Kouchak, M; Rashidi, M, 2023)	1.15
" However, it has several disadvantages such as poor water solubility, low bioavailability and low targeting, which seriously restrict its clinical application."	( Delivery of quercetin for breast cancer and targeting potentiation via hyaluronic nano-micelles. Li, M; Lin, K; Liu, Z; Sun, J; Wang, W; Wang, Z; Zhang, S; Zhao, Y; Zhen, Y, 2023)	1.29
" Given the importance of the active ingredient, dose selection and the improvement of quercetin's bioavailability remain to be explored."	( Mechanism of action of quercetin in rheumatoid arthritis models: meta-analysis and systematic review of animal studies. Gao, Y; Liu, X; Tao, T; Wang, F; Yao, H; Zheng, H, 2023)	1.44
" In the nutraceutical sector, natural flavonoids low bioavailability and solubility necessitate the application of delivery systems to enhance their efficacy."	( Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review. Abdulabbas, HT; Barbaresi, S; Ghasemian, A; Kareem, AS; Kouhpayeh, SA; Mazarzaei, A; Najafipour, S; Sotoudeh, M; Zarenezhad, E, 2023)	1.2
"In this study, the ability of zein nanospheres (NS) and zein nanocapsules containing wheat germ oil (NC) to enhance the bioavailability and efficacy of quercetin was evaluated."	( Zein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin. Campión, R; Collantes, M; Cristina Martínez-Oharriz, M; Gonzalez-Navarro, CJ; Irache, JM; Luisa Martínez López, A; Matías, C; Peñuelas, I; Sáiz-Abajo, MJ, 2023)	1.33
" However, little is known about the influence of dietary bioactive compounds on the bioavailability of PFOA and HFPO-TA."	( Influence of dietary bioactive compounds on the bioavailability and excretion of PFOA and its alternative HFPO-TA: Mechanism exploration. Chen, Y; Cui, X; Wu, H, 2023)	0.91
" Recent research suggests that using nanoformulations can help quercetin to overcome its hydrophobicity while also enhancing its stability and cellular bioavailability both in vitro and in vivo."	( Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies. Aggarwal, D; Chhabra, RS; Gupta, DS; Gupta, M; Joshi, H; Kaur, G; Ramniwas, S; Saini, AK; Sak, K; Singh, T; Tuli, HS, 2023)	1.47
" The attachment of a glucose unit impacts the stability and solubility of flavonoids and often determines their bioavailability and bioactivity."	( Glycosylation of Quercetin by Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products' Bioactivity. Dymarska, M; Janeczko, T; Kozłowska, E; Piegza, M; Stępień, Ł; Tronina, T; Urbaniak, M; Łużny, M, 2023)	1.25
" However, quercetin's bioavailability is frequently low due to its low water solubility, molecular stability, and absorption characteristics."	( Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives. Alizadeh, SR; Ebrahimzadeh, MA; Savadkouhi, N, )	0.75
") were discussed to improve water solubility and bioavailability of quercetin."	( Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives. Alizadeh, SR; Ebrahimzadeh, MA; Savadkouhi, N, )	0.58
" To enhance its oral bioavailability and efficacy, various quercetin-loaded nanosystems such as nanosuspensions, polymer nanoparticles, metal nanoparticles, emulsions, liposomes or phytosomes, micelles, solid lipid nanoparticles, and other lipid-based nanoparticles have been investigated in in-vitro cells, in-vivo animal models, and humans."	( Nano Drug Delivery Strategies for an Oral Bioenhanced Quercetin Formulation. Attar, ES; Chaudhari, VH; Deokar, CG; Devarajan, PV; Dyawanapelly, S, 2023)	1.4
" All compounds were obtained from the traditional Chinese medicine systems pharmacology (TCMSP) database, and active ingredients were selected by their oral bioavailability and drug-likeness index."	( Active ingredients Isorhamnetin of Croci Srigma inhibit stomach adenocarcinomas progression by MAPK/mTOR signaling pathway. Cai, T; Fu, YD; Li, Y; Liao, ZY; Shi, XF; Wang, KB; Yu, Q; Zhang, S, 2023)	0.91
" However, biomedical applications of Q are limited due to its low bioavailability and hydrophilicity."	( Electrospun fiber-based micro- and nano-system for delivery of high concentrated quercetin to cancer cells. Baranowska-Korczyc, A; Betlej, G; Cieślak, M; Deręgowska, A; Hudecki, A; Hudecki, J; Kęsik-Brodacka, M; Kolano-Burian, A; Krzemiński, P; Lewińska, A; Likus, W; Moskal, A; Rzeszutek, I; Warski, T; Wnuk, M; Wojnarowska-Nowak, R; Łyko-Morawska, D, 2023)	1.14
" This study provides new knowledge about key molecular mechanisms involved in QUE-mediated protection against AFB1 toxicity and encourages in vivo studies to assess QUE's bioavailability and beneficial effects on aflatoxicosis."	( Discovering the Protective Effects of Quercetin on Aflatoxin B1-Induced Toxicity in Bovine Foetal Hepatocyte-Derived Cells (BFH12). Barbarossa, A; Bardhi, A; Bassan, I; Dacasto, M; Giantin, M; Montanucci, L; Pauletto, M; Tolosi, R; Zaghini, A, 2023)	1.18
" Quercetin (QUR), as a flavonoid substance found in plants and fruits, has good anticancer and medicinal effects on brain tumors, but its low stability and bioavailability as well as the blood-brain barrier (BBB), prevent it from reaching brain tumors."	( Co-biopolymer of chitosan/carboxymethyl cellulose hydrogel improved by zinc oxide and graphene quantum dots nanoparticles as pH-sensitive nanocomposite for quercetin delivery to brain cancer treatment. Ostovar, S; Pourmadadi, M; Zaker, MA, 2023)	2.02
" Its anti-cancer and anti-inflammatory properties have been previously demonstrated, but its low bioavailability hampers its clinical use."	( Quercetin-loaded solid lipid nanoparticles exhibit antitumor activity and suppress the proliferation of triple-negative MDA-MB 231 breast cancer cells: implications for invasive breast cancer treatment. Hatami, M; Kheirollah, A; Khorsandi, L; Kouchak, M; Rashidi, M, 2023)	2.35
" Quercetin nanogels in the thermosensitive gel achieved sustained and controlled release of BDNF with non-Fick's diffusion, exhibited rapid brain distribution, and achieved nearly 50-fold enhanced bioavailability compared to oral quercetin."	( Enhanced antidepressant effects of BDNF-quercetin alginate nanogels for depression therapy. Chen, YB; Cui, YL; Dong, QW; Gao, LN; Song, XJ; Wang, Q; Xu, D, 2023)	2.09
" However, the therapeutic benefit of quercetin is hindered by its poor bioavailability and limited concentration in pancreatic islets."	( Controlled SPION-Exosomes Loaded with Quercetin Preserves Pancreatic Beta Cell Survival and Function in Type 2 Diabetes Mellitus. Chen, Y; Lv, X; Qin, D; Rao, L; Xia, H; Xiao, S; Yang, J; Zhu, C; Zhuang, M, 2023)	1.45
" However, the low bioavailability of AR-C17 due to its low water solubility restricts its application."	( Quercetin Enhances the Availability of 5-Heptadecylresorcinol by Inhibiting the Expression of P-gp. Fan, M; Jiang, L; Li, Y; Pan, W; Qian, H; Wang, L; Zhang, K, 2023)	2.35
" Moreover, the number of hydrogen bond acceptors/donors, solubility, polar surface area and bioavailability score of the vanillic acid and three flavonoids were acceptable compared to Lipinski's Rule of Five."	( Antioxidant activity, anti-tyrosinase activity, molecular docking studies, and molecular dynamic simulation of active compounds found in nipa palm vinegar. Chatatikun, M; Chuaijit, S; Klangbud, WK; Mudpan, A; Palachum, W; Pattaranggoon, NC; Pruksaphanrat, S; Sohbenalee, S; Tedasen, A; Yamasaki, K, 2023)	0.91
" Clinical studies investigating the safety and bioavailability of QUE are also discussed."	( Advances in Quercetin for Drug-Resistant Cancer Therapy: Mechanisms, Applications, and Delivery Systems. Kundrapu, DB; Malla, RR, 2023)	1.29

Dosage Studied

Model ApoE KO mice were fed with either a normal chow diet or a high fat diet (HFD) supplemented with or without dosed quercetin for 24 weeks. Concentration/time curves were determined for hypericin, pseudohypericin and hyperforin. Dose-response study suggested 1 μmol/L quercETin for in vivo study.

Excerpt	Relevance	Reference
" The level of kinase induction correlated well with dose-response curves for two characteristic IL-1-induced responses, PGE2 and IL-6 production."	( Evidence that MAP (mitogen-activated protein) kinase activation may be a necessary but not sufficient signal for a restricted subset of responses in IL-1-treated epidermoid cells. Bird, TA; Delaney, PB; Dower, SK; Schule, HD; Sims, JE; Thoma, B, 1992)	0.28
" Dose-response studies indicated that phosphorylation of the 67 kilodalton protein was particularly sensitive to inhibition by quercetin at concentrations that also inhibit neutrophil degranulation and superoxide production."	( The bioflavonoid quercetin inhibits neutrophil degranulation, superoxide production, and the phosphorylation of specific neutrophil proteins. Blackburn, WD; Heck, LW; Wallace, RW, 1987)	0.82
" Dose-response curves for mutagenicity of quercetin with or without AAF (5 micrograms/plate) were examined."	( The effect of quercetin on the mutagenicity of 2-acetylaminofluorene and benzo[alpha]pyrene in Salmonella typhimurium strains. Fukui, S; Hirai, K; Hirayama, T; Nohara, M; Ogawa, S; Tokuda, M, 1985)	0.89
" There were no significant differences between control and treated groups with regard to the number of dead implantations at any dosage level at any stage of the study in mice and rats."	( Studies on germinal effects of quercetin, a naturally occurring flavonoid. Aravindakshan, M; Chauhan, PS; Sundaram, K, 1985)	0.56
" The therapy lasted for 4 weeks; the dosage was 300 mg three times daily."	( Hypericum treatment of mild depressions with somatic symptoms. Hübner, WD; Lande, S; Podzuweit, H, 1994)	0.29
" The dosage was 3 x 300 mg hypericum extract LI 160 or 3 x 25 mg imipramine daily."	( Effectiveness and tolerance of the hypericum extract LI 160 in comparison with imipramine: randomized double-blind study with 135 outpatients. Arnoldt, KH; Hübner, WD; Vorbach, EU, 1994)	0.29
" During long-term dosing (3 x 300 mg/day), a steady-state was reached after 4 days."	( Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. Brockmöller, J; Kerb, R; Ploch, M; Roots, I; Staffeldt, B, 1994)	0.29
" The dosage was typically 300 to 900 mg total extract daily; the therapy duration was 2 to 6 weeks."	( Clinical investigation of the antidepressant effectiveness of hypericum. Harrer, G; Schulz, V, 1994)	0.29
" Many supplements are potent drugs that lack sufficient data on safety, dose-response relationships, drug interactions, and purity."	( Over-the-counter psychotropics: a review of melatonin, St John's wort, valerian, and kava-kava. Guenther, G; Heiligenstein, E, 1998)	0.3
" The dosage schedule was elaborated for the application of identical amounts of hyperforin in both extracts in each dosing group."	( Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG). Dimpfel, W; Mannel, M; Schober, F, 1998)	0.3
" After 3 weeks of treatment, dosage in 128 patients (21."	( St. John's Wort for depressive disorders: results of an outpatient study with the Hypericum preparation HYP 811. Mueller, BM, )	0.13
" After 3 weeks of treatment, the dosage could be reduced to one capsule per day in 35."	( Effects of hypericum extract HYP 811 in patients with psychovegetative disorders. Mueller, BM, )	0.13
" They also received the experimental diets containing one of test compounds (500 ppm) for 5 weeks, starting one week before the first dosing of AOM."	( Inhibition of azoxymethane-induced aberrant crypt foci in rats by natural compounds, caffeine, quercetin and morin. Honjo, S; Kawabata, K; Kohno, H; Matsunaga, K; Murakami, M; Shimada, R; Shimizu, M; Tanaka, T; Yamada, Y, )	0.35
"The observed p53 concentration changes upon stimulation by polyphenols are relatively small, do not follow a uniform pattern in the four cell lines tested, and do not exhibit a dose-response effect."	( Do wine polyphenols modulate p53 gene expression in human cancer cell lines? Diamandis, EP; Goldberg, DM; Grass, L; Levesque, M; Soleas, GJ, 2001)	0.31
" The antioxidant capacity of Gala apples and seven phenolic standards, determined by both ABTS(*)(-) and DPPH(*) scavenging assays, showed a dose-response of the first-order."	( Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. Kim, DO; Lee, CY; Lee, HJ; Lee, KW, 2002)	0.31
" After oral dosing of morin, both the parent form, morin, and its glucuronides and sulfates were present in the bloodstream."	( Profound difference in pharmacokinetics between morin and its isomer quercetin in rats. Chao, PD; Ho, HJ; Hou, YC; Hsiu, SL; Wen, CC, 2003)	0.55
" Inhibition of genotoxicity by spinach and peaches was not caused by any delay in maturation of micronucleated erythrocytes as shown by experiments with sampling times of 24, 48, and 72 h after dosing of BaP."	( Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids. Edenharder, R; Köttgen, V; Krieg, H; Platt, KL, 2003)	0.32
" Dose-response studies indicated that the prenylated flavonoids were effective inhibitors of lipoprotein oxidation with IC50 values <1 microM and had similar inhibitory potency compared to quercetin, but was not directly related to Cu binding."	( Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii. Abegaz, BM; Croft, KD; Dufall, KG; Ngadjui, BT; Simeon, KF, 2003)	0.51
" MRI studies using the relaxation of the T1 proton signal caused by Fe(2+) ions and the dose-dependent reversal of this effect by addition of quercetin in aqueous solution were used to guide us to the dosage of quercetin to be used in animal experimentations."	( Quercetin promotes functional recovery following acute spinal cord injury. Ghong, Z; Griebel, RW; Juurlink, BH; Kamencic, H; Kendall, E; Schültke, E, 2003)	1.96
" Dose-response (D-R) curves and kinetic measurements of GABA rho(1) currents were carried out in the presence or absence of antagonists."	( Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA rho 1 receptor. Calvo, DJ; Goutman, JD, 2004)	0.58
"The current research provides a simplified sample preparation procedure for the accurate estimation of quercetin in pure and in the pharmaceutical dosage form."	( Direct spectrophotometric determination of quercetin in the presence of ascorbic acid. Kuntic, V; Micic, S; Pejic, N; Vujic, Z, 2004)	0.8
" Body weight gain was reduced from week 10 to the end of the experiment in the 5% dosed males as compared to the 0% controls."	( Evaluation of the toxicity of enzymatically decomposed rutin with 13-weeks dietary administration to Wistar rats. Hasumura, M; Hirose, M; Imai, T; Mitsumori, K; Tamura, T; Yasuhara, K, 2004)	0.32
" dosage forms."	( Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin. Choi, JS; Jo, BW; Kim, YC, 2004)	0.54
" After dose-response studies, doses of 80 microM T3, 80 microM T4, 300 microM NA and 175 microM DES, which produced DNA damage but retained good cell viability, were chosen for further experiments with the antioxidant catalase and the flavonoids kaempferol and quercetin."	( Antioxidants modulate thyroid hormone- and noradrenaline-induced DNA damage in human sperm. Anderson, D; Baumgartner, A; Dobrzyńska, MM, 2004)	0.5
" Oral treatment of quercitrin (1 or 5 mg kg(-1) day(-1)) to colitic rats ameliorated the evolution of the inflammatory process induced when administered in a preventative dosing protocol."	( The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression. Camuesco, D; Comalada, M; Concha, A; Gálvez, J; Lorente, MD; Nieto, A; Rodríguez-Cabezas, ME; Zarzuelo, A, 2004)	0.32
" Interestingly, in both prostate and breast cancer cells, a remarkable dose-response parallelism was observed between flavonoid-induced inhibition of fatty acid synthesis, inhibition of cell growth, and induction of apoptosis."	( Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. Brusselmans, K; Swinnen, JV; Verhoeven, G; Vrolix, R, 2005)	0.33
"This paper describes a validated high-performance liquid chromatographic (HPLC) - photodiode array (PDA) detection method to quantitate five flavonol components as markers; rutin, quercitrin, quercetin, kaempferol and isorhamnetin for use in the quality control of Ginkgo biloba dosage forms."	( High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms. Dubber, MJ; Kanfer, I, 2004)	0.51
"A suitable method was developed to identify and quantitate five relevant flavonol marker compounds and was successfully used to assay some commercially available solid oral dosage forms of Ginkgo biloba ."	( High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms. Dubber, MJ; Kanfer, I, 2004)	0.32
" More in-depth studies on bioavailability should facilitate correlation of mechanisms determined in vitro with in vivo situations, increase our understanding of dose-response relationships, and facilitate extrapolation of results from animal studies to human situations."	( Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Hong, J; Lambert, JD; Liao, J; Yang, CS; Yang, GY, 2005)	0.33
" Concentration/time curves were determined for hypericin, pseudohypericin, hyperforin, the flavonoid aglycone quercetin, and its methylated form isorhamnetin for 48 h after single dosing and for 24 h on day 14 at the end of 2 weeks of continuous daily dosing."	( Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. Bässler, D; Schulz, HU; Schürer, M; Weiser, D, 2005)	0.76
" These flavonols suppressed intracellular calcium ion elevations in a dose-response manner, with morin being the weakest; they also inhibited phosphorylation of the calcium-insensitive protein kinase C theta (PKC theta)."	( Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Boucher, W; Cao, J; Cetrulo, CL; Christodoulou, S; Kempuraj, D; Madhappan, B; Papadopoulou, N; Theoharides, TC, 2005)	0.33
" Concentration/time curves were determined for the five constituents, for 48 h after single dosing and for 24 h on day 14 at the end of 2 weeks of continuous daily dosing."	( Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers. Bässler, D; Schulz, HU; Schürer, M; Weiser, D, 2005)	0.55
" Dose-response curves were established for each flavonol in the presence and absence of external metabolizing systems."	( In vitro basal and metabolism-mediated cytotoxicity of flavonoids. Raddi, MS; Soares, VC; Varanda, EA, 2006)	0.33
" There seems to be a need for a better definition of the concept itself and reconsideration of whether all biphasic dose-response curves should be considered representative for hormesis."	( The definition of hormesis and its implications for in vitro to in vivo extrapolation and risk assessment. Alink, GM; Rietjens, IM; van der Woude, H, 2005)	0.33
" In dose-response study, the ENRD activities in kaempferol (0."	( [Effects of kaempferol and quercetin on cytochrome 450 activities in primarily cultured rat hepatocytes]. Shen, XY; Zhang, FF; Zheng, YF; Zhu, HJ; Zhu, XQ, 2006)	0.63
" If the results are further confirmed in the clinical trials, the tamoxifen dosage should be adjusted when tamoxifen is administered with quercetin or quercetin-containing dietary supplements in order to avoid potential drug interactions."	( Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats. Choi, JS; Li, X; Shin, SC, 2006)	0.76
" Finally, QuerVO stimulated the ERK phosphorylation in a dose-response manner and this activation seems to be involved as one of the possible mechanisms for the biological effects of the complex."	( Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes. Barrio, DA; Correa, MJ; Etcheverry, SB; Ferrer, EG; Lezama, L; Naso, L; Rojo, T; Salinas, MV; Williams, PA, 2006)	0.57
"On days 4 and 11, nine blood samples and four peripheral blood mononuclear cell samples were drawn during a steady-state dosing interval."	( Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Chen, A; DiCenzo, R; Frerichs, V; Larppanichpoonphol, P; Morris, M; Predko, L; Reichman, R, 2006)	0.74
" The concentrations required to result in a 50% reduction in cell death (EC(50) value) were calculated from their dose-response curves."	( Free radical scavenging and cytoprotective activities of phenolic antioxidants. Adaim, A; Melton, LD; Skinner, MA; Stanley, RA; Zhang, J, 2006)	0.33
" After oral dosing of isorhamnetin, the mean values (n = 10) of C(max) were 57."	( Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin. He, J; Jiang, X; Lan, K, 2007)	0.6
" In this study quercetin inhibits, in a dose-response manner, tryptase and MCP-1."	( Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Castellani, ML; Conti, P; Frydas, S; Kempuraj, D; Simeonidou, I; Theoharides, TC; Vecchiet, J, 2006)	1.01
"10 g x kg(-1) x d(-1) dosage groups of hyperoside (P<0."	( In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik. Huang, ZM; Liu, HZ; Wu, GX; Wu, LL; Yang, XB, 2007)	0.34
" These 8 matrixes consisted primarily of simple dosage forms (e."	( Evaluation of a method to determine flavonol aglycones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography: collaborative study. Gray, D; LeVanseler, K; Meide, P; Waysek, EH, )	0.13
" The dose-response study showed that the IC50 values for ECG and Q3G on glucose uptake in BLMV were 294+/-89 microM and 357+/-52 microM, respectively."	( Interaction of flavonoids and intestinal facilitated glucose transporters. Chen, CH; Hsu, HJ; Huang, YJ; Lin, CJ, 2007)	0.34
" Optimal dosage of genistein, quercetin and in combination with chemicals for leukemia cells were determined by experiments."	( [Synergistic antileukemic effect of phytoestrogens and chemotherapeutic drugs on leukemic cell lines in vitro]. Chen, CS; Shen, J; Tai, YC; Wong, CH; Xie, Z; Zhang, WJ, 2008)	0.63
" The luc induction was determined in different tissues 8h after dosing the ER-luc male mice intraperitoneally (IP) or 14h after oral dosing."	( Food-associated estrogenic compounds induce estrogen receptor-mediated luciferase gene expression in transgenic male mice. Murk, AJ; Rietjens, IM; Ter Veld, MG; van den Berg, JH; van der Saag, PT; Zawadzka, E, 2008)	0.35
" Administered orally to male rats at dose levels of up to 2000 mg/kg body weight, quercetin did not increase the number of micronucleated polychromatic erythrocytes (MN-PCE) 24 or 48 h following dosing in the micronucleus assay."	( Evaluation of the potential in vivo genotoxicity of quercetin. Broschard, TH; Danielewska-Nikiel, B; Dasenbrock, J; Feige, K; Harwood, M; Lines, TC; Utesch, D, 2008)	0.82
" A dose-response study suggested that quercetin showed protective effects against Abeta(1-42) toxicity by modulating oxidative stress at lower doses, but higher doses were not only non-neuroprotective but also toxic."	( Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease. Abdul, HM; Ansari, MA; Butterfield, DA; Joshi, G; Opii, WO, 2009)	0.94
"45 micromol PhIP/kg bw and 30 micromol quercetin/kg bw significantly increased the blood AUC(0-8h) of PhIP in rats to 131+/-14% of the AUC(0-8h) for rats dosed with PhIP alone."	( Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats. Alink, GM; Freidig, AP; Groten, JP; Rietjens, IM; Schutte, ME; Spenkelink, B; Vaessen, JC; van de Sandt, JJ, 2008)	2.06
" The dosage regimen of etoposide in cancer therapy should take drug interaction into consideration when etoposide is administered with quercetin or dietary supplements containing quercetin."	( Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats. Choi, JS; Li, X, 2009)	0.95
" Further considerations for dose-response relationships, duration of supplementation, and susceptible biomarkers are required."	( Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients. Bae, SC; Jung, WJ; Lee, EJ; Sung, MK; Yu, R, 2009)	0.35
" Since EGb 761 is a composition of various components, it is important to identify which components are responsible for its anticancer effects to reduce the total dosage and to avoid toxicity."	( Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. Kang, JW; Kim, JH; Kim, KS; Kim, SH; Song, K; Yoon, JH, 2010)	0.71
"This study suggests that Ambrotose AO(R) capsules appear to be safe and most effective at a dosage of 4 capsules/day."	( A forced titration study of the antioxidant and immunomodulatory effects of Ambrotose AO supplement. Brooks, L; Cheras, PA; Conellan, P; Morris, C; Myers, SP; O'Connor, J; Rolfe, M; Stevenson, L, 2010)	0.36
" Depending on the duration and dosage of these modulators, 12."	( Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- mice. Garige, M; Gong, M; Lakshman, RM; Leckey, LC; Nagata, T; Spurney, CF; Varatharajalu, R, 2010)	1.8
" On the other side, studied flavonol augmented action of cytostatic drug in case of sensitive tumour cells what suggest, that it might allow to decrease dosage of cytostatic drugs and reduce negative side effects of the treatment."	( Antiproliferative and pro-apoptotic effects of quercetin on human pancreatic carcinoma cell lines EPP85-181P and EPP85-181RDB. Borska, S; Drag-Zalesinska, M; Dumanska, M; Dziegiel, P; Sopel, M; Wysocka, T; Zabel, M, 2010)	0.62
" The implementation of this assay to the screening of a highly diverse academic chemical library of 14,300 molecules yielded, after secondary assays and generation of dose-response curves, the identification of two natural product inhibitors, cyanidin and delphinidin."	( Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme. Haiech, J; Hibert, M; Kellenberger, E; Kuhn, I; Lobstein, A; Muller-Steffner, H; Rognan, D; Said-Hassane, F; Schuber, F; Villa, P, 2010)	0.36
" From this active fraction, seven compounds have been isolated and four compounds (pinosylvin, galangin, quercetin and methyl gallate) have been examined for their dose-response effect on the viability of A549 cells and on TNF-α inhibitory activity."	( Bioactivity guided isolation of anticancer constituents from leaves of Alnus sieboldiana (Betulaceae). Asakawa, Y; Kuzuhara, T; Ludwiczuk, A; Saha, A, 2011)	0.58
" Therefore, it appears that the development of oral doxorubicin preparations is possible, which will be more convenient than the intravenous dosage forms."	( Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin. Choi, JS; Kang, KW; Piao, YJ, 2011)	0.76
" The better results of lowering serum uric acid and protecting against renal failure were at the dosage of Que between 10 and 20 mg/kg."	( [Preventive and therapeutic effects of quercetin on hyperuricemia and renal injury in rats]. Fu, R; He, W; Yao, F; Zhang, R, 2011)	0.64
" Across all studies, subject presupplementation VO(2max) ranged from 41 to 64 mL·kg(-1)·min(-1) (median = 46), and median treatment duration was 11 d with a median dosage of 1000 mg·d(-1)."	( Quercetin and endurance exercise capacity: a systematic review and meta-analysis. Kressler, J; Millard-Stafford, M; Warren, GL, 2011)	1.81
" It is possible that a different dosing regimen, a combination of antioxidants or a different form of quercetin supplementation, may be needed to produce an increase in soldier performance."	( Effects of short-term quercetin supplementation on soldier performance. Hendrickson, NR; McClung, HL; Michniak-Kohn, BB; Nindl, BC; Sharp, MA; Staab, JS, 2012)	0.91
" The observed effect may be beneficial to develop oral valsartan dosage forms using safe P-gp inhibitor (quercetin) to improve its oral bioavailability."	( Pharmacokinetic interaction study between quercetin and valsartan in rats and in vitro models. Babu, PR; Challa, SR; Challa, VR; Johnson, B; Maheswari, C, 2013)	0.87
" DHQ was more effective in restraining soy bean oil oxidation, and a dose-response relationship was observed."	( Extraction of dihydroquercetin from Larix gmelinii with ultrasound-assisted and microwave-assisted alternant digestion. Ma, C; Wang, W; Yang, F; Yang, L; Zhao, C; Zu, Y, 2012)	0.7
" Single and 14-day repeat dosing in rats and dogs had no influence on body weight, feed consumption, blood chemistry, and haematology at any dose level."	( Production, composition and toxicology studies of Enzogenol® Pinus radiata bark extract. Frampton, CM; Frevel, MA; Gilchrist, NL; Grigsby, WJ; Pipingas, A, 2012)	0.38
" Furthermore, the duration of benefit and the influence of different dosing regimens remain unclear."	( Treatment with quercetin and 3',4'-dihydroxyflavonol inhibits platelet function and reduces thrombus formation in vivo. Jackson, DE; Linden, MD; Mosawy, S; Woodman, OL, 2013)	0.74
" The results showed no statistically significant difference in quercetin absorption among groups due to high variability within groups receiving quercetin from same dosage form."	( Comparison of quercetin pharmacokinetics following oral supplementation in humans. Clarkson, PM; Conca, KR; Dunne, CP; Kaushik, D; Michniak-Kohn, B; O'Fallon, K, 2012)	0.98
" We assessed accumulations of polyphenols in the rat brain following oral dosage with a Cabernet Sauvignon red wine and tested brain-targeted polyphenols for potential beneficial AD disease-modifying activities."	( Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease. Chen, TY; Cooper, B; Ferruzzi, MG; Gong, B; Ho, L; Janle, EM; Lobo, J; Pasinetti, GM; Percival, SS; Simon, JE; Talcott, ST; Wang, J; Wu, QL, 2013)	0.64
" These data show that nanocapsulated quercetin possesses the potential bioactivity to reduce the drug dosage frequency, as well as increase patient compliance."	( Co-encapsulation of biodegradable nanoparticles with silicon quantum dots and quercetin for monitored delivery. Ahire, J; Bao, Y; Chao, Y; Wang, Q, 2013)	0.89
" However, the pre-treatment of Quercetin in a dose-response manner prevented these changes and restored the expansion of neurospheres preferably by neutralizing the oxidative conditions and thereby reducing peroxynitrite formation, protein nitration and PK-M2 depletion."	( Quercetin prevents protein nitration and glycolytic block of proliferation in hydrogen peroxide insulted cultured neuronal precursor cells (NPCs): Implications on CNS regeneration. Arora, R; Khan, HA; Sajad, M; Sharma, J; Umar, S; Zargan, J; Zargar, MA, 2013)	2.12
" Oral treatments of quercetin and αOR at this dosage exhibited no anti-allergic effect, and IQC showed less effect than EMIQ."	( Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice. Kanemaru, M; Makino, T; Mizukami, H; Okuyama, S; Shimizu, R; Tanaka, H, 2013)	0.94
" The Cd-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd."	( Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats. Aktas, C; Erboga, M; Kanter, M; Unsal, C, 2015)	0.85
" QUE, specially at the dosage of 50mg/kg, can act as an antioxidant and anti-inflammatory agent, becoming a promising adjuvant in the treatment of diabetes mellitus."	( Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats. Abdala, FH; Costa, MM; Danesi, CC; Duarte, MM; Felin, DV; França, RT; Graça, DL; Lopes, ST; Maciel, RM; Martins, DB; Mazzanti, CM; Paim, FC; Palma, HE; Schetinger, MR; Schmatz, R; Stefanello, N; Zimpel, CK, 2013)	0.65
" This study examines the dose-response of DNA-damage pathway to these compounds in HT1080 cells (a human cell line with wild-type p53) at doses relevant to human exposure."	( Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin. Andersen, ME; Carmichael, PL; Clewell, RA; Dent, M; Ross, SM; Sun, B; Trask, OJ; White, A, 2013)	0.61
" Quercetin was administered by gavage daily for 10 days at dosage 50 mg kg(-1) ."	( Evaluation of the protective effect of quercetin against cisplatin-induced renal and testis tissue damage and sperm parameters in rats. Aldemir, M; Avcı, A; Ener, K; Evirgen, O; Gürleyik, E; Kösemehmetoğlu, K; Okulu, E; Topal, F, 2014)	1.58
" In vivo evaluation and histopatholgical study of the selected QT SNEDDSs were achieved after administration of paracetamol over dosage to albino rats."	( Design and optimization of self-nanoemulsifying delivery system to enhance quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity. Ahmed, OA; Ahmed, TA; Badr, JM; Badr-Eldin, SM; El-Say, KM; Tawfik, MK, 2014)	0.63
"Microparticle tablets represent a promising dosage form for QUE delivery to the colon in the oral therapy of inflammatory-based disorders."	( Chitosan-xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin. Caddeo, C; Díez-Sales, O; Fadda, AM; Manconi, M; Merino-Sanjuán, M; Nácher, A, 2014)	0.62
" A multidisciplinary approach has been employed herein, in an effort to reveal its mode of action including dose-response antiproliferative activity and induced apoptosis effect, biochemical and physicochemical assays, and computational calculations."	( Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity. Briasoulis, E; Chatziathanasiadou, MV; Chi, SW; Gerothanassis, IP; Hatzimichael, E; Karali, E; Kolettas, E; Kostaras, E; Mantzaris, MD; Primikyri, A; Shin, JS; Tzakos, AG, 2014)	0.67
" Our results suggest that rutin may be useful in the management of inflammatory bowel disease in appropriate dosage conditions."	( Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis. Aranda, C; de Medina, FS; Marín, JJ; Martínez-Augustin, O; Mascaraque, C; Monte, MJ; Ocón, B; Suárez, MD; Zarzuelo, A, 2014)	0.4
" In conclusion, QUR protected against DOX-induced nephrotoxicity with a provision to dosage adjustment."	( Dual effects of quercetin in doxorubicin-induced nephrotoxicity in rats and its modulation of the cytotoxic activity of doxorubicin on human carcinoma cells. Heeba, GH; Mahmoud, ME, 2016)	0.78
" Although significant advances have been made in understanding determinants of quercetin bioavailability, additional research in controlled trials is needed to more comprehensively examine dose-response effects, whether its cardioprotective activities improve in response to its greater bioavailability, and if the putative health benefits of quercetin are mediated directly or indirectly from one or more of its metabolites generated during xenobiotic metabolism."	( Endogenous and exogenous mediators of quercetin bioavailability. Bruno, RS; Guo, Y, 2015)	0.92
"The aim of this work was to prepare a combined drug dosage form of famotidine (FAM) and quercetin (QRT) to augment treatment of gastric ulcer."	( Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study. Abourehab, MA; Ahmed, OA; Khaled, KA; Sarhan, HA, 2015)	0.91
" graveolens produced rightward parallel displacement of carbachol dose-response curves and reduced over 35 % of the maximum smooth muscle contraction."	( Relaxant effects of a hydroalcoholic extract of Ruta graveolens on isolated rat tracheal rings. Águila, L; de Campos, RR; Mansilla, K; Ordenes, J; Romero, F; Ruedlinger, J; Salvatici, R, 2015)	0.42
" However, concurrent dosing of these natural products with ADR is limited due to their low solubility, and low oral bioavailability."	( Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. Alani, AWG; Carlson, LJ; Cote, B; Rao, DA, 2015)	0.71
"With increasing dosage of quercetin, significant decrease in proliferation and increase in apoptosis was observed."	( Quercetin reverses tamoxifen resistance in breast cancer cells. Chen, T; Feng, D; Kong, H; Lin, Q; Qi, K; Tao, L; Wang, H; Wei, W; Zhang, H, )	1.87
"Proliferation inhibition and apoptosis in MCF-7Ca/TAM-R cells increase with increasing dosage of quercetin."	( Quercetin reverses tamoxifen resistance in breast cancer cells. Chen, T; Feng, D; Kong, H; Lin, Q; Qi, K; Tao, L; Wang, H; Wei, W; Zhang, H, )	1.79
" On the 30th day, hormonal dosing was performed to confirm hypothyroidism, and the animals were subsequently treated with 10 or 25 mg/kg quercetin for 60 days."	( Hypothyroidism Enhanced Ectonucleotidases and Acetylcholinesterase Activities in Rat Synaptosomes can be Prevented by the Naturally Occurring Polyphenol Quercetin. Abdalla, FH; Baldissarelli, J; Calgaroto, NS; Cardoso, AM; Dias, GR; Loro, VL; Martins, CC; Morsch, VM; Pelinson, LP; Reichert, KP; Santi, A; Schetinger, MR; Schmatz, R, 2017)	0.86
" In conclusion, QPTN could be used as a potential intravenous dosage form for the treatment of liver cancer owing to the enhanced pharmacological effects of QT with increased liver targeting."	( Quercetin-loaded poly (lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer. Deng, S; Gao, D; Gao, M; Guan, X; Liu, H; Lv, L; Tian, Y; Xu, H; Zhang, C, 2016)	1.88
" Oral quercetin supplementation protected respiratory function for 4-6 months during a 12 month dosing regimen."	( Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice. Ballmann, CG; Quindry, JC; Ross, JW; Selsby, JT; Spaulding, HR, 2016)	1.43
"The results indicate that quercetin has not only a positive dose-response on qualitative and quantitative histological characteristics of the compact bone of female rabbits as it would be expected."	( Structural changes in femoral bone microstructure of female rabbits after intramuscular administration of quercetin. Adamkovicova, M; Babosova, R; Capcarova, M; Duranova, H; Grosskopf, B; Kovacova, V; Martiniakova, M; Omelka, R, 2016)	0.95
" The cadmium-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 mL/kg/ day for 30 days, resulting in a dosage of 1 mg/kg cadmium."	( Role of Quercetin in Cadmium-Induced Oxidative Stress, Testicular Damage, and Apoptosis in Rats. Aktas, C; Aktoz, T; Kanter, B; Kanter, M; Ozen, F; Yarali, O, 2016)	0.87
" Dose-response curves were generated to evaluate the protective effect on hair cells."	( Quercetin protects against hair cell loss in the zebrafish lateral line and guinea pig cochlea. Hashimoto, M; Hirose, Y; Kanagawa, E; Sugahara, K; Takemoto, Y; Yamashita, H, 2016)	1.88
" Model ApoE KO mice were fed with either a normal chow diet or a high fat diet (HFD) supplemented with or without dosed quercetin for 24 weeks."	( Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase. Guo, X; Liu, L; Tang, Y; Wang, J; Xiao, L; Yao, P; Zhang, S; Zhou, F, 2017)	2.11
" Intraperitoneal administration of 4-pentenoic acid was performed once daily during seven days, the used dosage was 20mg/kg."	( [ACTION OF L-CARNITINE, CORVITIN AND THEIR COMBINATION ON FUNCTIONAL STATE OF LIVER IN EXPERIMENTAL MODEL OF REYE SYNDROME IN RATS]. Antelava, N; Ghonghadze, M; Liluashvili, K; Okujava, M; Pachkoria, K, 2017)	0.46
" In the subgroup analysis, a significant reducing effect was observed in trials with ⩾500 mg/day dosage (WMD: -0."	( Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. Firoozi, D; Ghorbani, M; Mazloom, Z; Mohammadi-Sartang, M; Sherafatmanesh, S, 2017)	0.74
"(ZDF) rats and their lean controls (LN) were dosed with a Standardized Grape Polyphenol (SGP) Mixture consisting of grape seed extract, Concord grape juice and resveratrol (RES) by oral gavage for 10 days."	( Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Chen, TY; Cooper, B; Ferruzzi, MG; Ho, L; Janle, EM; Pasinetti, GM; Simon, JE; Talcott, ST; Todd, G; Wang, J; Wu, QL, 2017)	0.46
" The mice dosed with tamoxifen were divided into four groups: high‑ or low‑quercetin group, valproic acid (VPA) group and untreated group."	( Quercetin alleviates generalized hyperalgesia in mice with induced adenomyosis. Liu, X; Nie, J, 2017)	2.13
" QU at a dosage of 150 mg/kg was administered orally in collagen-induced arthritis rats and then the clinical symptoms were monitored."	( Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. Wu, X; Xu, M; Yang, Y; Zhang, X; Zhao, C; Zhao, F, 2018)	1.92
" The proposed formulation design can significantly help in reduction of dose and dosing frequency, which ultimately enhance patient compliance with decreased drug toxicity."	( Artesunate-quercetin/luteolin dual drug nanofacilitated synergistic treatment for malaria: A plausible approach to overcome artemisinin combination therapy resistance. Kumar, RS; Puttappa, N; Yamjala, K, 2017)	0.84
"The major objective of this study was to develop and validate a high-performance liquid chromatography (HPLC) method for the determination of TAX in a semisolid dosage forms and then to evaluate ex vivo permeations across porcine vaginal mucosa and human skin."	( Taxifolin: Evaluation Through Ex vivo Permeations on Human Skin and Porcine Vaginal Mucosa. Alves, MC; Bhering, CAP; Brandao, MAF; de Almeida, PA; de O Ferreira, A; Polonini, HC; Raposo, NRB, 2018)	0.48
" dosage highly unlikely to have an effect on nocturia or any other pharmacologically significant effect in humans."	( Investigations on the constituents of SagaPro tablets, a food supplement manufactured from Eyjolfsson, R; Kowal, NM; Olafsdottir, ES, 2017)	0.46
" The results demonstrated accelerated wound-healing with significant decrease in wound closure time compared to conventional dosage form."	( In vitro and In vivo characterization of quercetin loaded multiphase hydrogel for wound healing application. Jangde, R; Singh, D; Singh, MR; Srivastava, S, 2018)	0.75
" Dose-response study suggested 1 μmol/L quercetin for in vivo study."	( Topical application of quercetin improves wound healing in pressure ulcer lesions. Wang, X; Wang, Z; Yin, G, 2018)	1.06
" Despite the lack of effectiveness in preventing bone loss, a significant dose-response trend was observed in the phytochemical-rich diets in bone adipocyte number compared to ovariectomized control rats."	( Synergistic Phytochemicals Fail to Protect Against Ovariectomy Induced Bone Loss in Rats. Ambati, S; Baile, CA; Bass, EF; Della-Fera, MA; Hartzell, DL; Hohos, NM; Kelso, EW; Miller, CN; Rayalam, S; Trunnell, ER; Yang, JY, 2018)	0.48
"We conducted a multicenter phase II trial of sequential dosing cohorts to evaluate the efficacy of targeting PDI with isoquercetin to reduce hypercoagulability in cancer patients at high risk for thrombosis."	( Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer. Aggarwal, A; Bauer, KA; Caughey, T; Flaumenhaft, R; Furie, B; Hidalgo, M; Kuemmerle, N; Liebman, HA; McLaughlin, M; Neuberg, D; Puligandla, M; Schlechter, BL; Stopa, JD; Wong, E; Wun, T; Zwicker, JI, 2019)	0.96
" Naringenin, naringenin chalcone, and quercetin all showed strong antiallergic activity after intravenous dosing (0."	( In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice. Boix Montañés, A; Escribano-Ferrer, E; Garcia-Sala, X; Lamuela-Raventos, RM; Queralt Regué, J, 2019)	1
" At the end of this period, the animals were killed with a high dosage of thiopental anaesthesia (50 mg/kg)."	( The Effect of Taxifolin on Cisplatin-Induced Pulmonary Damage in Rats: A Biochemical and Histopathological Evaluation. Cimen, FK; Kuzucu, M; Olmez, H; Suleyman, Z; Tosun, M; Unver, E, 2019)	0.51
" Co-administration of mRQ with ADR can reduce ADR dosing through chemosensitization while being cardioprotective."	( Chemosensitization and mitigation of Adriamycin-induced cardiotoxicity using combinational polymeric micelles for co-delivery of quercetin/resveratrol and resveratrol/curcumin in ovarian cancer. Alani, AWG; Cote, B; Fatease, AA; LeBlanc, N; Nguyen, DX; Rao, DA; Shah, V, 2019)	0.72
" Admistration of quercetin at the dosage of 15 and 20 mg/kg to septic rats caused significant reduction in the ROS levels."	( Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression. Cui, W; Hu, G; Liu, J; Mu, L; Peng, J; Qiao, L, 2019)	2.3
" The role of UV-B rays in inducing secondary plant metabolites is enhanced by new plastic films, which, as a result of their optical properties, permit the necessary dosage of UV-B to be transmitted into the greenhouse to stimulate such metabolites without altering the harvest."	( Use of greenhouse-covering films with tailored UV-B transmission dose for growing 'medicines' through plants: rocket salad case. Graziani, G; Mormile, P; Rippa, M; Ritieni, A, 2019)	0.51
" However, it is possible that a lower dosage from plant sources could be effective due to of its higher bioavailability compared to the aglycone form."	( Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Dabeek, WM; Marra, MV, 2019)	0.95
" Partial least squares discriminant analysis showed significant differences in chemical content in the dosed rats."	( Plasma metabolomics analysis of endogenous and exogenous metabolites in the rat after administration of Lonicerae Japonicae Flos. Chen, L; Li, L; Ma, S; Wang, D; Wang, X, 2020)	0.56
" The developed quercetin nanorod/MCC formulation could be used for further pharmaceutical dosage or food supplements processing."	( Preparation of quercetin nanorod/microcrystalline cellulose formulation via fluid bed coating crystallization for dissolution enhancement. Cheng, S; Chow, PS; Dong, Y; Guo, L; Hu, J; Sheng, F, 2020)	1.26
" The oral administration of quercetin at the dosage of 25 and 50 mg/kg for 28 days remarkably reduced the level of blood glucose, glycosylated hemoglobin (Hb), and hepatic glycogen but enhanced plasma Hb concentration."	( Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase. Adeyemi, OT; Aiyegoro, OA; Chukwuma, CI; Matsabisa, MG; Nwaogu, G; Oyedemi, SO; Swain, SS, 2020)	2.29
"5, and VPA (800 mg/kg) was administered orally in a single dosage on gestational day 12."	( Quercetin prevents alterations of behavioral parameters, delta-aminolevulinic dehydratase activity, and oxidative damage in brain of rats in a prenatal model of autism. Baldissarelli, J; de Mattos, BDS; de Souza, AA; Gamaro, GD; Pedra, NS; Soares, MSP; Spanevello, RM; Spohr, L; Stefanello, FM; Teixeira, FC, 2020)	2
" Also, rapid gastrointestinal digestion of QT seems to be a key barrier for its clinical translations for oral drug delivery in conventional dosage form."	( Recent Advances in Liposomal Drug Delivery System of Quercetin for Cancer Targeting: A Mechanistic Approach. Alshehri, S; Altamimi, MA; Das, SS; Hussain, A; Imam, SS; Singh, SK; Verma, PRP, 2020)	0.81
" As results, quercetin showed contrasting dose-response to cellular behaviors dependent on the ROS-regulated p53 signaling pathways."	( Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study. Huang, B; Pan, X; Xia, X; Xu, Z; Zhao, D; Zheng, X, 2020)	2.37
" A dose-response curve was generated by the cumulative addition of acetylcholine (ACh) or sodium nitroprusside (SNP)."	( Quercetin improves vascular endothelial function through promotion of autophagy in hypertensive rats. Fan, Y; Han, T; Lin, X; Wang, C; Wang, F; Wu, S, 2020)	2
" The use of NSAIDs together with an overall reduction of their dosage and time of assumption has been reduced as well."	( Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies. Accardi, M; Baietti, MG; Fadin, M; Fratter, A; Nicoletti, MC; Pellizzato, M, 2020)	0.83
" Longer term and especially dose-response studies on mildly insulin resistant participants are required to establish the extent to which (poly)phenols and (poly)phenol-rich foods may improve insulin resistance in compromised groups."	( Effects of Polyphenols on Insulin Resistance. Sheedy, K; Williamson, G, 2020)	0.56
" Dose-response effects showed an L-shaped curve between the total intake of five flavonoids and the risk of the MetS."	( The association of dietary flavonoids, magnesium and their interactions with the metabolic syndrome in Chinese adults: a prospective cohort study. Han, T; Jia, Y; Jin, S; Liu, J; Na, L; Sun, C; Zhao, X, 2021)	0.62
" This may be related to factors such as the population and the dosage and time of taking natural products involved in different studies."	( Natural products: The role and mechanism in low-density lipoprotein oxidation and atherosclerosis. Chen, W; Feng, X; Li, L; Xu, S; Zhang, L; Zhang, S, 2021)	0.62
" A modern pharmacy has proposed a number of dosage forms that improve bioavailability, including dental films or chips, which are intended for topical use and belong to the transdermal therapeutic systems and are applied by application to the mucous membrane of the mouth and periodontium."	( Substantiation of attention around antioxidants of plant origin for use in complex pharmacotherapy of diseases of the oral cavity. Chornij, N; Kritsak, M; Pavliuk, B; Prokopovych, O; Stechyshyn, I, 2021)	0.62
" This paper investigated different concentrations of selected commercially sourced analytical-grade pure chemicals as potential drug absorption enhancers in vitro and ex vivo to determine the lowest effective concentrations for optimizing drug absorption in oral dosage forms."	( Determination of effective concentrations of drug absorption enhancers using in vitro and ex vivo models. Enslin, GM; Kheoane, PS; Tarirai, C, 2021)	0.62
", curcumin and quercetin), at specific concentrations, in dosage forms could improve the bioavailability of the BCS Class III and IV drugs that are substrates of CYP3A4 and p-glycoprotein."	( Determination of effective concentrations of drug absorption enhancers using in vitro and ex vivo models. Enslin, GM; Kheoane, PS; Tarirai, C, 2021)	0.97
" However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin."	( Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy. Dhanya, R, 2022)	2.38
" Orally dosed QUE/pLA (50 mg QUE/kg) in rats exhibited significantly prolonged systemic exposure, possibly due to the sustained release of QUE."	( Development of Poly(lipoic acid) Nanoparticles with Improved Oral Bioavailability and Hepatoprotective Effects of Quercetin. Banik, S; Onoue, S; Sato, H; Yamada, K, 2022)	0.93
" Further investigations based on the results of interaction index and isobologram analysis showed that the antioxidant activity (DPPH, ABTS, and reducing power) of the combination of caffeic acid with SAC presented an increase with the raising of their individual concentrations in their mixture and along with a dose-response manner."	( Antioxidant Interactions between S-allyl-L-cysteine and Polyphenols Using Interaction Index and Isobolographic Analysis. Dong, C; Duan, S; Liu, J; Qiu, F; Tao, L; Wang, B; Wang, S; Zhao, G, 2022)	0.72
" Dose/time-response images predicted a modest association between Qu dosage consumption/administration length and therapeutic efficacy, with the optimal dosage at 90-150 mg/kg/d and administration length ranging from 8 weeks to 12 weeks."	( Effective dose/duration of natural flavonoid quercetin for treatment of diabetic nephropathy: A systematic review and meta-analysis of rodent data. Deng, H; Feng, X; Guo, X; Li, Q; Li, Z; Lu, C; Ma, X; Wang, J; Yan, S; Zeng, J; Zhao, Z, 2022)	0.98
"Seventy-two women with PCOS were randomly allocated to one of two intervention groups, and each received a daily dosage of 500 mg of Quercetin for the intervention group or a placebo for the control group for a period of 40 days from the start of the menstrual cycle until the day of ovulation."	( Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial. Amidi, F; Amini, N; Moini, A; Parivr, K; Rudbari, NH; Vaez, S, 2023)	2.56
" All of the extracts revealed significant antioxidant capacities along a dosage gradient."	( Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells. Almaghrabi, S; Baothman, BK; Hjazi, A; Jamous, YF; Kauts, S; Khan, AA; Minocha, T; Mujalli, A; Obaid, AA; Shabir, S; Singh, MP; Singh, SK; Vamanu, E; Yousuf, S, 2022)	0.72
" The poor water solubility of this flavanonol at ambient conditions inhibits its implementation in clinical practice as an injectable dosage form."	( Solubility Enhancement of Dihydroquercetin via "Green" Phase Modification. Beloborodov, VL; Bogdanov, AG; Davidovich, GN; Dzuban, AV; Ilyasov, IR; Pankov, DI; Saverina, EA; Selivanova, IA; Shilov, GV; Terekhov, RP; Utenyshev, AN; Zhevlakova, AK, 2022)	1
"All participants completed the scheduled drug dosing regimen (108/108 doses) and planned assessments (60/60)."	( Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability. Gelfond, J; Goros, M; Hashmi, S; Justice, J; Kellogg, D; Kirkland, J; Kritchevsky, S; LeBrasseur, N; Limper, A; Masternak, M; Musi, N; Nambiar, A; Pascual, R; Prata, L; Tchkonia, T, 2023)	1.21
" It is suggested that a single dosage of Quercetin have a reno-protective impact in the case of renal I/R injury."	( The Effects of Quercetin on Apoptosis and Antioxidant Activity in a Renal Ischemia/Reperfusion Injury Animal Model. Aria, N; Bagheri, A; Bagheri, Y; Ghiabi, S; Khajenouri, M; Radman, G; Rezaei, F, 2023)	1.53
"Transdermal penetration of therapeutic moieties from topical dosage forms always remains a challenge due to the presence of permeation impeding keratin which should be addressed."	( Exploring the Potent Combination of Quercetin-Boronic Acid, Epalrestat, and Urea Containing Nanoethosomal Keratolytic Gel for the Treatment of Diabetic Neuropathic Pain: In Vitro and In Vivo Studies. Abid, S; Ameer, N; Azeem, M; Danish, Z; Hanif, M; Khan, M; Khurshid, U; Mahmood, K; Pandey, K; Qaiser, M; Razaque, G; Sajid Chughtai, FR; Usman Abid, HM, 2023)	1.19
" From 4-13 months of age, C57BL/6 male and female mice received monthly oral dosing of either 100 mg/kg Fisetin or a 5 mg/kg Dasatinib (D) plus 50 mg/kg Quercetin (Q) cocktail."	( Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment. Bartke, A; Fang, Y; Hascup, ER; Hascup, KN; McFadden, S; Medina, D; Peck, MR; Quinn, K; Stockwell, R, 2023)	1.33
" To investigate the mechanism of action, conducted assays of antioxidant activity, measured the dosage of inflammatory cytokines, quantified mucus, treated with inhibitors (IND, L-NAME, glibenclamide, and yohimbine), performed histopathological analysis, and measured gastric acid secretion."	( Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models. Arunachalam, K; Damazo, AS; Figueiredo, FF; Martins, DTO; Muller, JAI; Oliveira, DM; Serio, BFD; Silva, MJD; Venturini, CL, 2024)	1.44