Sodium/potassium/calcium exchanger 2

A sodium/potassium/calcium exchanger 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UI40]

Synonyms

Na(+)/K(+)/Ca(2+)-exchange protein 2;
Retinal cone Na-Ca+K exchanger;
Solute carrier family 24 member 2

Research

Bioassay Publications (0)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0)	18.7374
1990's	0 (0)	18.2507
2000's	0 (0)	29.6817
2010's	0 (0)	24.3611
2020's	0 (0)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
potassium chloride	Homo sapiens (human)	IC50	280,000.0000	1	0

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
potassium chloride	Homo sapiens (human)	EC50	280,000.0000	1	0

Enables

This protein enables 3 target(s):

Target	Category	Definition
calcium, potassium:sodium antiporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). [TC:2.A.19.4.1]
symporter activity	molecular function	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
calcium channel activity	molecular function	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
photoreceptor inner segment	cellular component	The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. [GOC:add, PMID:12019563]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
learning	biological process	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. [ISBN:0582227089, ISBN:0721662544]
memory	biological process	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). [GOC:curators, ISBN:0582227089]
sodium ion transmembrane transport	biological process	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
establishment of localization in cell	biological process	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
neuron cellular homeostasis	biological process	The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. [GOC:BHF, GOC:mah]
calcium ion import	biological process	The directed movement of calcium ions into a cell or organelle. [GOC:mah]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
calcium ion import across plasma membrane	biological process	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
intracellular calcium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]
long-term synaptic depression	biological process	A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph]
long-term synaptic potentiation	biological process	A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph]