metronidazole has been researched along with Necrosis in 41 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A histological finding on the 15th day indicated the possibility of amoebic enteritis, and the patient was started on metronidazole therapy." | 3.81 | Fulminant amoebic enteritis that developed in the perinatal period. ( Goto, M; Matsuoka, T; Mizushima, Y, 2015) |
| "Twelve patients with extremely severe uveitis and two patients with necrotizing (chorio-)retinitis were treated with a combination of antibiotics consisting of penicillin G, gentamicin and metronidazole." | 3.66 | [High-dosage combination antibiotic treatment in severe therapy-resistant uveitis and necrotizing (chorio)retinitis]. ( Dietze, U; Fricke, HJ; Heydenreich, A; Illéssy, A; Schröder, D, 1983) |
| "We present a case of amoebic colitis, misdiagnosed as inflammatory bowel disease and treated with corticosteroids, leading to severe necrotizing enterocolitis." | 2.50 | Misdiagnosed amoebic colitis leading to severe dysentery and necrotizing colitis--report of a case and review of the literature. ( Christiansen, JJ; Eivindson, MV; Larsen, CS; Mogensen, TH; Tøttrup, A, 2014) |
| "Tetanus is a rare diagnosis in the developed world but sporadic cases do occur." | 1.40 | Cephalic tetanus complicating geriatric fall. ( La Varis, T; Mason, D; McCabe, J, 2014) |
| "Fournier gangrene is a necrotizing fasciitis of the perineal and genital region, which almost exclusively affects men." | 1.33 | [Extensive Fournier gangrene. A dermatologic emergency]. ( Aschoff, R; Baldauf, A; Leike, S; Meurer, M; Wirth, MP, 2006) |
| "A model of colorectal cancer liver metastases in male inbred CBA mice was used." | 1.31 | Interstitial laser hyperthermia for colorectal liver metastases: the effect of thermal sensitization and the use of a cylindrical diffuser tip on tumor necrosis. ( Christophi, C; Malcontenti-Wilson, C; Muralidharan, V, 2002) |
| "Wounds with necrotising fasciitis are often malodorous and produce copious exudate." | 1.31 | Management of a heavily exuding, painful wound with necrotising subcutaneous infection. ( Fairhurst, J; Ovens, N, 2002) |
| "The efficacy of hyperbaric oxygen (HBO) alone and in combination with several antimicrobial agents was evaluated in a lethal model of gas gangrene in mice." | 1.29 | Evaluation of antimicrobials combined with hyperbaric oxygen in a mouse model of clostridial myonecrosis. ( Anderson, LH; Mehm, WJ; Muhvich, KH, 1994) |
| "Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis." | 1.28 | Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992) |
| "Necrotising fasciitis of the genitalia still carries a high risk of mortality and morbidity, frequently necessitating long periods of hospitalisation and repeated surgical procedures." | 1.27 | Fournier's gangrene: necrotising fasciitis of the male genitalia. ( Arndt, TC; Bahlmann, JC; Fourie, IJ, 1983) |
| "The authors described clinicomorphological correlations in the evaluation of the efficacy of preoperative radiotherapy combined with metronidazole (MZ) in laryngeal cancer patients." | 1.27 | [Morphology of laryngeal cancer in radiotherapy combined with the use of metronidazole]. ( Andreev, VG; Lushnikov, EF; Solov'eva, LP, 1985) |
| "Twenty-seven patients with severe acute amebic dysentery were studied at the International Centre for Diarrhoeal Diseases Research Hospital in Dacca, Bangladesh." | 1.26 | Amebic colitis: correlation of proctoscopy before treatment and barium enema after treatment. ( Gilman, RH; Koster, F; Martinez, CR; Rabbani, GH, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (24.39) | 18.7374 |
| 1990's | 11 (26.83) | 18.2507 |
| 2000's | 10 (24.39) | 29.6817 |
| 2010's | 9 (21.95) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Duployez, C | 1 |
| Le Guern, R | 1 |
| Tinez, C | 1 |
| Lejeune, AL | 1 |
| Robriquet, L | 1 |
| Six, S | 1 |
| Loïez, C | 1 |
| Wallet, F | 1 |
| Prieto Herman Reinehr, C | 1 |
| Kalil, CLPV | 1 |
| Bakos, RM | 1 |
| Mogensen, TH | 1 |
| Christiansen, JJ | 1 |
| Eivindson, MV | 1 |
| Larsen, CS | 1 |
| Tøttrup, A | 1 |
| McCabe, J | 1 |
| La Varis, T | 1 |
| Mason, D | 1 |
| Goto, M | 1 |
| Mizushima, Y | 1 |
| Matsuoka, T | 1 |
| George, R | 1 |
| Prasoona, TS | 1 |
| Kandasamy, R | 1 |
| Cherian, R | 1 |
| Celine, T | 1 |
| Jeba, J | 1 |
| Murali, S | 1 |
| Mathew, D | 1 |
| Hussain, A | 1 |
| Mahmood, H | 1 |
| Ansari, T | 1 |
| El-Hasani, S | 1 |
| Le Falher, G | 1 |
| Makinson, A | 1 |
| Eden, A | 1 |
| Lesnik, A | 1 |
| Le Moing, V | 1 |
| Reynes, J | 1 |
| Gomes-Filho, JE | 1 |
| Duarte, PC | 1 |
| de Oliveira, CB | 1 |
| Watanabe, S | 1 |
| Lodi, CS | 1 |
| Cintra, LT | 1 |
| Bernabé, PF | 1 |
| Rebai, W | 1 |
| Makni, A | 1 |
| Azouz, H | 1 |
| Ksantini, R | 1 |
| Kourda, J | 1 |
| Chebbi, F | 1 |
| Daghfous, A | 1 |
| Ayadi, S | 1 |
| Ftériche, F | 1 |
| Bedioui, H | 1 |
| Jouini, M | 1 |
| Kacem, M | 1 |
| Ammous, A | 1 |
| Ben Safta, Z | 1 |
| Ghafoor, M | 1 |
| Halsnad, M | 1 |
| Fowell, C | 1 |
| Millar, BG | 1 |
| Muralidharan, V | 1 |
| Malcontenti-Wilson, C | 1 |
| Christophi, C | 1 |
| Chattopadhyay, A | 1 |
| Bale, S | 1 |
| Tebbie, N | 1 |
| Price, P | 1 |
| Aiken, K | 1 |
| Aschoff, R | 1 |
| Baldauf, A | 1 |
| Leike, S | 1 |
| Wirth, MP | 1 |
| Meurer, M | 1 |
| Gaggl, AJ | 1 |
| Rainer, H | 1 |
| Grund, E | 1 |
| Chiari, FM | 1 |
| West, D | 1 |
| Fricke, HJ | 1 |
| Heydenreich, A | 1 |
| Dietze, U | 1 |
| Illéssy, A | 1 |
| Schröder, D | 1 |
| Bahlmann, JC | 1 |
| Fourie, IJ | 1 |
| Arndt, TC | 1 |
| Martinez, CR | 1 |
| Gilman, RH | 1 |
| Rabbani, GH | 1 |
| Koster, F | 1 |
| Asmussen, T | 1 |
| Beck, H | 1 |
| Greibe, J | 1 |
| Gianotti, L | 1 |
| Munda, R | 1 |
| Gennari, R | 1 |
| Pyles, R | 1 |
| Alexander, JW | 1 |
| Sun, XM | 1 |
| MacKendrick, W | 1 |
| Tien, J | 1 |
| Huang, W | 1 |
| Caplan, MS | 1 |
| Hsueh, W | 1 |
| Muhvich, KH | 1 |
| Anderson, LH | 1 |
| Mehm, WJ | 1 |
| Thom, S | 1 |
| Finlay, IG | 1 |
| West, SD | 1 |
| Brunskill, NJ | 1 |
| Ovens, N | 1 |
| Fairhurst, J | 1 |
| Donaldson, M | 1 |
| Heyneman, D | 1 |
| Dempster, R | 1 |
| Garcia, L | 1 |
| Martínez-Gigena, MP | 1 |
| Shibayama-Salas, M | 1 |
| Tsutsumi, V | 1 |
| Martínez-Palomo, A | 1 |
| Stoykewych, AA | 1 |
| Beecroft, WA | 1 |
| Cogan, AG | 1 |
| McMullen, D | 1 |
| Füllner, G | 1 |
| Müller, W | 1 |
| Mathieson, PW | 1 |
| Thiru, S | 1 |
| Oliveira, DB | 1 |
| Abrosimov, AIu | 1 |
| Skoropad, VIu | 1 |
| Plonka, AJ | 1 |
| Schentag, JJ | 1 |
| Messinger, S | 1 |
| Adelman, MH | 1 |
| Francis, KL | 1 |
| Williams, JS | 1 |
| Giamarellou, H | 1 |
| Kiel, RJ | 1 |
| Crane, LR | 1 |
| Aguilar, J | 1 |
| Palutke, WA | 1 |
| Cowden, JW | 1 |
| Lushnikov, EF | 1 |
| Andreev, VG | 1 |
| Solov'eva, LP | 1 |
| Jansen, GT | 1 |
| Morgan, PN | 1 |
| McQueen, JN | 1 |
| Bennett, WE | 1 |
5 reviews available for metronidazole and Necrosis
| Article | Year |
|---|---|
Misdiagnosed amoebic colitis leading to severe dysentery and necrotizing colitis--report of a case and review of the literature.
Topics: Adrenal Cortex Hormones; Aged; Amebicides; Diagnostic Errors; Dysentery, Amebic; Humans; Immunosuppr | 2014 |
Managing tissue necrosis associated with oral carcinoma.
Topics: Aged; Anti-Infective Agents; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Mouth Neoplasm | 2004 |
A palliative approach to the management of malodour from malignant fungating tumours.
Topics: Adult; Anti-Infective Agents; Anus Neoplasms; Attitude to Health; Bandages; Carcinoma, Squamous Cell | 2007 |
Effect of different regimens of gut decontamination on bacterial translocation and mortality in experimental acute pancreatitis.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Decontamination; Erythromycin; Gram-Negative Bacteria | 1995 |
A role for hyperbaric oxygen in clostridial myonecrosis.
Topics: Animals; Combined Modality Therapy; Gas Gangrene; Hyperbaric Oxygenation; Metronidazole; Mice; Myosi | 1993 |
3 trials available for metronidazole and Necrosis
| Article | Year |
|---|---|
A topical metronidazole gel used to treat malodorous wounds.
Topics: Administration, Cutaneous; Anti-Infective Agents; Attitude of Health Personnel; Attitude to Health; | 2004 |
Local oxygen therapy for treating acute necrotizing periodontal disease in smokers.
Topics: Acute Disease; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin-Po | 2006 |
Effect of different regimens of gut decontamination on bacterial translocation and mortality in experimental acute pancreatitis.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Decontamination; Erythromycin; Gram-Negative Bacteria | 1995 |
34 other studies available for metronidazole and Necrosis
| Article | Year |
|---|---|
Panton-Valentine Leukocidin-Secreting Staphylococcus aureus Pneumonia Complicating COVID-19.
Topics: Adult; Anti-Bacterial Agents; Bacterial Toxins; Betacoronavirus; Cefotaxime; Clindamycin; Clinical L | 2020 |
Unusual case of rosacea fulminans after topical metronidazole application.
Topics: Administration, Cutaneous; Adult; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Isot | 2019 |
Cephalic tetanus complicating geriatric fall.
Topics: Accidental Falls; Aged, 80 and over; Anti-Infective Agents; Debridement; Facial Muscles; Female; For | 2014 |
Fulminant amoebic enteritis that developed in the perinatal period.
Topics: Adult; Antiprotozoal Agents; Colon; Developed Countries; Dysentery, Amebic; Enteritis; Female; Human | 2015 |
Improving malodour management in advanced cancer: a 10-year retrospective study of topical, oral and maintenance metronidazole.
Topics: Administration, Cutaneous; Administration, Oral; Anti-Infective Agents; Female; Head and Neck Neopla | 2017 |
Pneumomediastinum, stomach wall and hepatic portal vein gas secondary to partial necrosis of the stomach wall.
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; A | 2009 |
[Two cases of pulmonary gangrene in HIV-infected patients: favorable outcome without surgery].
Topics: Acetamides; Adult; Alcoholism; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Gangre | 2011 |
Tissue reaction to a triantibiotic paste used for endodontic tissue self-regeneration of nonvital immature permanent teeth.
Topics: Animals; Anti-Bacterial Agents; Apexification; Biocompatible Materials; Calcinosis; Calcium Hydroxid | 2012 |
[Complicated sigmoid tumor: perforated amebiasis].
Topics: Antiprotozoal Agents; Colectomy; Colon, Sigmoid; Dysentery, Amebic; Humans; Intestinal Perforation; | 2010 |
Impetigo presenting as an acute necrotizing swelling of the lower lip in an adult patient.
Topics: Acetamides; Acute Disease; Adult; Anti-Infective Agents; Diagnosis, Differential; Drug Combinations; | 2012 |
Interstitial laser hyperthermia for colorectal liver metastases: the effect of thermal sensitization and the use of a cylindrical diffuser tip on tumor necrosis.
Topics: Animals; Colorectal Neoplasms; Hyperthermia, Induced; Laser Therapy; Liver Neoplasms, Experimental; | 2002 |
Necrotizing amebic colitis: the plea for an early diagnosis.
Topics: Amebicides; Colon; Dysentery, Amebic; Gastrointestinal Hemorrhage; Humans; Infant; Metronidazole; Ne | 2003 |
[Extensive Fournier gangrene. A dermatologic emergency].
Topics: Adult; Cefotaxime; Combined Modality Therapy; Drug Therapy, Combination; Emergencies; Follow-Up Stud | 2006 |
[High-dosage combination antibiotic treatment in severe therapy-resistant uveitis and necrotizing (chorio)retinitis].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Chorioretinitis; Drug Therapy, Combination; Female; Gentam | 1983 |
Fournier's gangrene: necrotising fasciitis of the male genitalia.
Topics: Adult; Aged; Chloramphenicol; Fasciitis; Gangrene; Genital Diseases, Male; Humans; Male; Metronidazo | 1983 |
Amebic colitis: correlation of proctoscopy before treatment and barium enema after treatment.
Topics: Barium Sulfate; Dysentery, Amebic; Enema; Humans; Intestinal Mucosa; Metronidazole; Necrosis; Procto | 1982 |
[Amebic necrosis of the liver].
Topics: Chloroquine; Humans; Liver Abscess, Amebic; Male; Metronidazole; Middle Aged; Necrosis | 1982 |
Endogenous bacterial toxins are required for the injurious action of platelet-activating factor in rats.
Topics: Analysis of Variance; Animals; Bacterial Toxins; Drug Therapy, Combination; Endotoxins; Intestines; | 1995 |
Evaluation of antimicrobials combined with hyperbaric oxygen in a mouse model of clostridial myonecrosis.
Topics: Animals; Clindamycin; Combined Modality Therapy; Disease Models, Animal; Female; Gas Gangrene; Hyper | 1994 |
[An efficient method to reduce odors].
Topics: Administration, Cutaneous; Anti-Infective Agents; Gels; Humans; Metronidazole; Necrosis; Odorants; S | 1999 |
Complications associated with influenza infection.
Topics: Acute Kidney Injury; Alphainfluenzavirus; Drug Therapy, Combination; Humans; Imipenem; Influenza, Hu | 2002 |
Management of a heavily exuding, painful wound with necrotising subcutaneous infection.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasciiti | 2002 |
Epizootic of fatal amebiasis among exhibited snakes: epidemiologic, pathologic, and chemotherapeutic considerations.
Topics: Amebiasis; Animals; Animals, Zoo; Emetine; Entamoebiasis; Enteritis; Gastroenteritis; Inflammation; | 1975 |
Histological changes during healing of experimental amebic liver abscess treated with metronidazole.
Topics: Animals; Cricetinae; Entamoeba histolytica; Granuloma; Liver; Liver Abscess, Amebic; Male; Mesocrice | 1992 |
Fatal necrotizing fasciitis of dental origin.
Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female; | 1992 |
Topical metronidazole. Part II.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Metronidazole; Middle | 1992 |
[The therapy of swimbladder inflammation (renicola sphaerosporosis) of carp].
Topics: Air Sacs; Animals; Antiprotozoal Agents; Carps; Cyclohexanes; Fatty Acids, Unsaturated; Fish Disease | 1992 |
Mercuric chloride-treated brown Norway rats develop widespread tissue injury including necrotizing vasculitis.
Topics: Animals; Autoantibodies; Basement Membrane; Colon; Duodenum; Ivermectin; Kidney Glomerulus; Male; Me | 1992 |
[The morphological characteristics of sarcoma M1 cells before and after irradiation].
Topics: Animals; Cell Death; Dose-Response Relationship, Radiation; Metronidazole; Microscopy, Electron; Nec | 1991 |
Effects of enteral and intravenous antimicrobial treatment on survival following intestinal ischemia in rats.
Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Drug Therapy, Combination; Gentamicins; Gram-Ne | 1989 |
Myonecrosis of the abdominal wall, complicating radical hysterectomy.
Topics: Abdominal Muscles; Amikacin; Bacillus; Cefotaxime; Clindamycin; Drug Therapy, Combination; Escherich | 1987 |
Corneal perforation caused by dysgonic fermenter-2.
Topics: Animals; Animals, Domestic; Bacterial Infections; Cefotaxime; Ceftizoxime; Dogs; Drug Therapy, Combi | 1987 |
[Morphology of laryngeal cancer in radiotherapy combined with the use of metronidazole].
Topics: Adult; Aged; Humans; Laryngeal Neoplasms; Metronidazole; Middle Aged; Necrosis; Radiation Tolerance; | 1985 |
The brown recluse spider bite: controlled evaluation of treatment using the white rabbit as an animal model.
Topics: Animals; Disease Models, Animal; Female; Inflammation; Injections; Injections, Intramuscular; Methyl | 1971 |