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Pepsin A
[no definition available]
Synonyms
EC 3.4.23.1
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| enalkiren | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| cgp 38560a | Sus scrofa (pig) | IC50 | 20.4500 | 2 | 2 |
| ditekiren | Sus scrofa (pig) | IC50 | 6.8000 | 1 | 1 |
| pepstatin | Sus scrofa (pig) | IC50 | 0.0110 | 5 | 5 |
| pepstatin | Sus scrofa (pig) | Ki | 0.0000 | 2 | 2 |
| aliskiren | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
New pepstatin analogues: synthesis and pepsin inhibition.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.Journal of medicinal chemistry, , Volume: 28, Issue:11, 1985
Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985