A mitogen-activated protein kinase kinase kinase 20 that is encoded in the genome of human. [PRO:DNx]
EC 2.7.11.25; This protein enables 11 target(s): This protein is located in 3 target(s): This protein is active in 1 target(s): This protein is involved in 21 target(s):
Human cervical cancer suppressor gene 4 protein;
HCCS-4;
Leucine zipper- and sterile alpha motif-containing kinase;
MLK-like mitogen-activated protein triple kinase;
Mitogen-activated protein kinase kinase kinase MLT;Research
Bioassay Publications (10)
Timeframe Studies on this Protein(%) All Drugs % pre-1990 0 (0.00) 18.7374 1990's 0 (0.00) 18.2507 2000's 4 (40.00) 29.6817 2010's 6 (60.00) 24.3611 2020's 0 (0.00) 2.80 Compounds (238)
Drugs with Inhibition Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) birb 796 Homo sapiens (human) IC50 1.0000 1 1 hts 466284 Homo sapiens (human) IC50 1.4000 1 1 gw-5074 Homo sapiens (human) IC50 1.8900 1 1 ly2090314 Homo sapiens (human) IC50 20.0000 1 1 plx4032 Homo sapiens (human) IC50 0.0272 2 2 ly3009120 Homo sapiens (human) IC50 0.0390 1 1 Drugs with Activation Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) fasudil Homo sapiens (human) Kd 30.0000 1 1 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline Homo sapiens (human) Kd 30.0000 1 1 sb 202190 Homo sapiens (human) Kd 10.0000 1 1 imatinib Homo sapiens (human) Kd 11.7333 3 3 triciribine phosphate Homo sapiens (human) Kd 30.0000 1 1 staurosporine Homo sapiens (human) Kd 10.0000 2 2 picropodophyllin Homo sapiens (human) Kd 30.0000 1 1 gefitinib Homo sapiens (human) Kd 16.6667 3 3 lestaurtinib Homo sapiens (human) Kd 15.5667 3 3 perifosine Homo sapiens (human) Kd 30.0000 1 1 vatalanib Homo sapiens (human) Kd 12.9333 3 3 ruboxistaurin Homo sapiens (human) Kd 16.6667 3 3 canertinib Homo sapiens (human) Kd 1.7397 3 3 birb 796 Homo sapiens (human) Kd 0.8600 2 2 cyc 202 Homo sapiens (human) Kd 20.0000 2 2 sb 203580 Homo sapiens (human) Kd 4.4000 2 2 enzastaurin Homo sapiens (human) Kd 20.0000 2 2 erlotinib Homo sapiens (human) Kd 16.6667 3 3 lapatinib Homo sapiens (human) Kd 20.0000 3 4 sorafenib Homo sapiens (human) Kd 0.1870 4 4 pd 173955 Homo sapiens (human) Kd 0.3000 1 1 s 1033 Homo sapiens (human) Kd 0.5315 2 2 xl147 Homo sapiens (human) Kd 30.0000 1 1 bms 387032 Homo sapiens (human) Kd 16.6667 3 3 sf 2370 Homo sapiens (human) Kd 30.0000 1 1 tandutinib Homo sapiens (human) Kd 15.0000 4 4 vx-745 Homo sapiens (human) Kd 10.0000 2 2 dasatinib Homo sapiens (human) Kd 0.1023 3 3 ha 1100 Homo sapiens (human) Kd 30.0000 1 1 7-epi-hydroxystaurosporine Homo sapiens (human) Kd 30.0000 1 1 zd 6474 Homo sapiens (human) Kd 13.4000 3 3 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide Homo sapiens (human) Kd 10.0000 1 1 imd 0354 Homo sapiens (human) Kd 30.0000 1 1 sirolimus Homo sapiens (human) Kd 30.0000 1 2 alvocidib Homo sapiens (human) Kd 16.6667 3 3 bosutinib Homo sapiens (human) Kd 0.6465 2 2 orantinib Homo sapiens (human) Kd 30.0000 1 1 su 11248 Homo sapiens (human) Kd 15.0000 4 4 palbociclib Homo sapiens (human) Kd 30.0000 1 1 jnj-7706621 Homo sapiens (human) Kd 10.0000 1 1 vx680 Homo sapiens (human) Kd 11.8667 3 3 cyc 116 Homo sapiens (human) Kd 6.8390 1 1 everolimus Homo sapiens (human) Kd 30.0000 1 1 ekb 569 Homo sapiens (human) Kd 1.0375 2 2 axitinib Homo sapiens (human) Kd 3.6075 2 2 temsirolimus Homo sapiens (human) Kd 30.0000 1 1 pd 184352 Homo sapiens (human) Kd 10.0000 1 1 on 01910 Homo sapiens (human) Kd 30.0000 1 1 av 412 Homo sapiens (human) Kd 30.0000 1 1 telatinib Homo sapiens (human) Kd 0.4770 1 1 y-39983 Homo sapiens (human) Kd 30.0000 1 1 cp 547632 Homo sapiens (human) Kd 30.0000 1 1 bms345541 Homo sapiens (human) Kd 10.0000 1 1 lenvatinib Homo sapiens (human) Kd 30.0000 1 1 pd 0325901 Homo sapiens (human) Kd 30.0000 1 1 midostaurin Homo sapiens (human) Kd 15.0000 4 4 px-866 Homo sapiens (human) Kd 30.0000 1 1 ripasudil Homo sapiens (human) Kd 30.0000 1 1 osi 930 Homo sapiens (human) Kd 7.7310 1 1 ki 20227 Homo sapiens (human) Kd 3.3000 1 1 scio-469 Homo sapiens (human) Kd 30.0000 1 1 cp 724714 Homo sapiens (human) Kd 20.0000 2 2 pi103 Homo sapiens (human) Kd 10.0000 2 2 hmn-214 Homo sapiens (human) Kd 30.0000 1 1 tivozanib Homo sapiens (human) Kd 30.0000 1 1 hki 272 Homo sapiens (human) Kd 15.7500 2 2 tofacitinib Homo sapiens (human) Kd 16.6667 3 3 n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide Homo sapiens (human) Kd 10.0000 1 1 cediranib Homo sapiens (human) Kd 23.3333 2 3 masitinib Homo sapiens (human) Kd 15.3850 2 2 ly-2157299 Homo sapiens (human) Kd 30.0000 1 1 pazopanib Homo sapiens (human) Kd 16.6667 3 3 azd 6244 Homo sapiens (human) Kd 20.0000 2 2 su 14813 Homo sapiens (human) Kd 16.6667 3 3 bibw 2992 Homo sapiens (human) Kd 23.3333 2 3 binimetinib Homo sapiens (human) Kd 30.0000 1 1 sotrastaurin Homo sapiens (human) Kd 30.0000 1 1 aee 788 Homo sapiens (human) Kd 13.6380 1 1 saracatinib Homo sapiens (human) Kd 2.9850 1 1 vx 702 Homo sapiens (human) Kd 30.0000 1 1 crenolanib Homo sapiens (human) Kd 30.0000 1 1 tg100-115 Homo sapiens (human) Kd 20.0000 2 2 cc 401 Homo sapiens (human) Kd 30.0000 1 1 bms 599626 Homo sapiens (human) Kd 30.0000 1 1 exel-7647 Homo sapiens (human) Kd 30.0000 1 1 volasertib Homo sapiens (human) Kd 30.0000 1 1 pha 665752 Homo sapiens (human) Kd 10.0000 1 1 azd 7762 Homo sapiens (human) Kd 30.0000 1 1 regorafenib Homo sapiens (human) Kd 0.2740 1 1 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one Homo sapiens (human) Kd 20.0000 2 2 brivanib Homo sapiens (human) Kd 20.0000 2 2 mp470 Homo sapiens (human) Kd 30.0000 1 1 rgb 286638 Homo sapiens (human) Kd 1.1130 1 1 np 031112 Homo sapiens (human) Kd 30.0000 1 1 at 7519 Homo sapiens (human) Kd 20.0000 2 2 bms-690514 Homo sapiens (human) Kd 0.2820 1 1 bi 2536 Homo sapiens (human) Kd 20.0000 2 2 inno-406 Homo sapiens (human) Kd 0.0650 1 1 nvp-ast487 Homo sapiens (human) Kd 0.0023 2 2 kw 2449 Homo sapiens (human) Kd 15.2900 2 2 danusertib Homo sapiens (human) Kd 30.0000 1 1 abt 869 Homo sapiens (human) Kd 16.6667 3 3 azd 8931 Homo sapiens (human) Kd 30.0000 1 1 arq 197 Homo sapiens (human) Kd 30.0000 1 1 azd 1152 Homo sapiens (human) Kd 30.0000 1 1 pf 00299804 Homo sapiens (human) Kd 30.0000 1 1 ridaforolimus Homo sapiens (human) Kd 30.0000 1 1 ch 4987655 Homo sapiens (human) Kd 30.0000 1 1 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamide Homo sapiens (human) Kd 30.0000 1 2 cc-930 Homo sapiens (human) Kd 30.0000 1 1 gw 2580 Homo sapiens (human) Kd 10.0000 2 2 tak 285 Homo sapiens (human) Kd 30.0000 1 1 idelalisib Homo sapiens (human) Kd 30.0000 1 1 crizotinib Homo sapiens (human) Kd 20.0000 2 2 osi 906 Homo sapiens (human) Kd 30.0000 1 1 chir-265 Homo sapiens (human) Kd 10.0420 3 3 motesanib Homo sapiens (human) Kd 0.0443 3 3 fostamatinib Homo sapiens (human) Kd 30.0000 1 1 trametinib Homo sapiens (human) Kd 30.0000 1 1 mln8054 Homo sapiens (human) Kd 16.6667 3 3 pf-562,271 Homo sapiens (human) Kd 30.0000 1 1 GDC-0879 Homo sapiens (human) Kd 10.0000 1 1 jnj-26483327 Homo sapiens (human) Kd 30.0000 1 1 ly2603618 Homo sapiens (human) Kd 30.0000 1 1 tg100801 Homo sapiens (human) Kd 30.0000 1 1 dactolisib Homo sapiens (human) Kd 30.0000 1 1 bgt226 Homo sapiens (human) Kd 30.0000 1 1 gsk 461364 Homo sapiens (human) Kd 20.0000 2 2 azd 1152-hqpa Homo sapiens (human) Kd 11.1333 3 3 nvp-tae684 Homo sapiens (human) Kd 10.0000 1 1 enmd 2076 Homo sapiens (human) Kd 30.0000 1 1 e 7050 Homo sapiens (human) Kd 0.6950 1 1 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone Homo sapiens (human) Kd 30.0000 1 1 tak-901 Homo sapiens (human) Kd 30.0000 1 1 gdc-0973 Homo sapiens (human) Kd 30.0000 1 2 buparlisib Homo sapiens (human) Kd 30.0000 1 1 azd 1480 Homo sapiens (human) Kd 30.0000 1 1 azd8330 Homo sapiens (human) Kd 30.0000 1 1 pha 848125 Homo sapiens (human) Kd 30.0000 1 1 ro5126766 Homo sapiens (human) Kd 30.0000 1 1 fedratinib Homo sapiens (human) Kd 15.3250 2 2 gsk690693 Homo sapiens (human) Kd 20.0000 2 2 14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene Homo sapiens (human) Kd 30.0000 1 1 azd5438 Homo sapiens (human) Kd 30.0000 1 1 pf 04217903 Homo sapiens (human) Kd 30.0000 1 1 gdc 0941 Homo sapiens (human) Kd 20.0000 2 2 icotinib Homo sapiens (human) Kd 30.0000 1 1 ph 797804 Homo sapiens (human) Kd 30.0000 1 1 kx-01 Homo sapiens (human) Kd 30.0000 1 1 plx 4720 Homo sapiens (human) Kd 0.0410 1 1 mk 5108 Homo sapiens (human) Kd 30.0000 1 1 cx 4945 Homo sapiens (human) Kd 30.0000 1 1 cudc 101 Homo sapiens (human) Kd 30.0000 1 1 arry-614 Homo sapiens (human) Kd 1.2540 1 1 tak 593 Homo sapiens (human) Kd 30.0000 1 1 mln 8237 Homo sapiens (human) Kd 30.0000 1 1 sgx 523 Homo sapiens (human) Kd 20.0000 2 2 bms 754807 Homo sapiens (human) Kd 30.0000 1 1 bms 777607 Homo sapiens (human) Kd 30.0000 1 1 sgi 1776 Homo sapiens (human) Kd 30.0000 1 1 pci 32765 Homo sapiens (human) Kd 1.7050 1 1 ponatinib Homo sapiens (human) Kd 0.0410 1 1 amg 900 Homo sapiens (human) Kd 30.0000 1 2 mk-1775 Homo sapiens (human) Kd 30.0000 1 1 AMG-208 Homo sapiens (human) Kd 30.0000 1 1 quizartinib Homo sapiens (human) Kd 16.6667 3 3 at13148 Homo sapiens (human) Kd 30.0000 1 1 tak 733 Homo sapiens (human) Kd 30.0000 1 1 mk 2206 Homo sapiens (human) Kd 30.0000 1 1 sns 314 Homo sapiens (human) Kd 30.0000 1 1 lucitanib Homo sapiens (human) Kd 30.0000 1 1 pf-04691502 Homo sapiens (human) Kd 30.0000 1 1 n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide Homo sapiens (human) Kd 30.0000 1 1 dcc-2036 Homo sapiens (human) Kd 0.3880 1 1 cabozantinib Homo sapiens (human) Kd 30.0000 1 1 defactinib Homo sapiens (human) Kd 30.0000 1 1 ly2584702 Homo sapiens (human) Kd 30.0000 1 1 incb-018424 Homo sapiens (human) Kd 20.0000 2 2 poziotinib Homo sapiens (human) Kd 30.0000 1 1 asp3026 Homo sapiens (human) Kd 30.0000 1 1 entrectinib Homo sapiens (human) Kd 30.0000 1 1 pexidartinib Homo sapiens (human) Kd 30.0000 1 1 TAK-580 Homo sapiens (human) Kd 0.4500 1 1 gsk 2126458 Homo sapiens (human) Kd 30.0000 1 1 emd1214063 Homo sapiens (human) Kd 30.0000 1 1 gsk 1838705a Homo sapiens (human) Kd 10.0000 1 1 pf 3758309 Homo sapiens (human) Kd 30.0000 1 1 gdc 0980 Homo sapiens (human) Kd 30.0000 1 1 azd2014 Homo sapiens (human) Kd 30.0000 1 1 (5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol Homo sapiens (human) Kd 30.0000 1 1 plx4032 Homo sapiens (human) Kd 0.3160 1 1 gsk 1363089 Homo sapiens (human) Kd 0.0490 2 2 arry-334543 Homo sapiens (human) Kd 30.0000 1 1 kin-193 Homo sapiens (human) Kd 30.0000 1 1 mk 2461 Homo sapiens (human) Kd 30.0000 1 1 bay 869766 Homo sapiens (human) Kd 30.0000 1 1 as 703026 Homo sapiens (human) Kd 30.0000 1 1 baricitinib Homo sapiens (human) Kd 30.0000 1 1 dabrafenib Homo sapiens (human) Kd 0.1840 1 1 pki 587 Homo sapiens (human) Kd 30.0000 1 1 n-(3-fluoro-4-((1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5 yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide Homo sapiens (human) Kd 30.0000 1 1 ribociclib Homo sapiens (human) Kd 30.0000 1 1 mk-8033 Homo sapiens (human) Kd 30.0000 1 1 pha 793887 Homo sapiens (human) Kd 30.0000 1 1 sb 1518 Homo sapiens (human) Kd 2.9780 1 1 abemaciclib Homo sapiens (human) Kd 30.0000 1 1 mk-8776 Homo sapiens (human) Kd 30.0000 1 2 afuresertib Homo sapiens (human) Kd 30.0000 1 1 gsk 1070916 Homo sapiens (human) Kd 30.0000 1 1 jnj38877605 Homo sapiens (human) Kd 30.0000 1 2 dinaciclib Homo sapiens (human) Kd 30.0000 1 1 gilteritinib Homo sapiens (human) Kd 30.0000 1 2 alectinib Homo sapiens (human) Kd 30.0000 1 1 glpg0634 Homo sapiens (human) Kd 30.0000 1 1 encorafenib Homo sapiens (human) Kd 0.7850 1 1 bms-911543 Homo sapiens (human) Kd 30.0000 1 1 gsk2141795 Homo sapiens (human) Kd 30.0000 1 1 azd8186 Homo sapiens (human) Kd 30.0000 1 1 byl719 Homo sapiens (human) Kd 30.0000 1 1 cep-32496 Homo sapiens (human) Kd 0.9980 1 1 rociletinib Homo sapiens (human) Kd 30.0000 1 1 ceritinib Homo sapiens (human) Kd 30.0000 1 1 azd1208 Homo sapiens (human) Kd 30.0000 1 1 vx-509 Homo sapiens (human) Kd 30.0000 1 1 debio 1347 Homo sapiens (human) Kd 30.0000 1 1 volitinib Homo sapiens (human) Kd 30.0000 1 1 osimertinib Homo sapiens (human) Kd 30.0000 1 1 at 9283 Homo sapiens (human) Kd 30.0000 1 1 otssp167 Homo sapiens (human) Kd 0.1010 1 1 chir 258 Homo sapiens (human) Kd 16.6667 3 3 osi 027 Homo sapiens (human) Kd 30.0000 1 1 nintedanib Homo sapiens (human) Kd 20.0000 2 2 bay 80-6946 Homo sapiens (human) Kd 30.0000 1 1 pp242 Homo sapiens (human) Kd 1.8000 1 1 Enables
Target Category Definition magnesium ion binding molecular function Binding to a magnesium (Mg) ion. [GOC:ai] RNA binding molecular function Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] protein serine/threonine kinase activity molecular function Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925] JUN kinase kinase kinase activity molecular function Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). [GOC:bf] MAP kinase kinase kinase activity molecular function Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. [PMID:9561267] protein binding molecular function Binding to a protein. [GOC:go_curators] ATP binding molecular function Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] protein kinase activator activity molecular function Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai] ribosome binding molecular function Binding to a ribosome. [GOC:go_curators] small ribosomal subunit rRNA binding molecular function Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. [GOC:elh] protein serine kinase activity molecular function Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989] Located In
Target Category Definition nucleus cellular component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] cytoplasm cellular component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] cytosol cellular component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] Active In
Target Category Definition cytosol cellular component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] Involved In
Target Category Definition DNA damage checkpoint signaling biological process A signal transduction process that contributes to a DNA damage checkpoint. [GOC:mah] MAPK cascade biological process An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267] protein phosphorylation biological process The process of introducing a phosphate group on to a protein. [GOC:hb] inflammatory response biological process The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] cytoskeleton organization biological process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:dph, GOC:jl, GOC:mah] JNK cascade biological process A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. [PMID:11790549, PMID:20811974, PMID:23125017] cell death biological process Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] cell differentiation biological process The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] stress-activated protein kinase signaling cascade biological process The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal. [GOC:mah] p38MAPK cascade biological process A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. [PMID:20811974, PMID:23125017, PMID:32794416] embryonic digit morphogenesis biological process The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. [GOC:bf, GOC:jl, UBERON:0002544] positive regulation of apoptotic process biological process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] protein autophosphorylation biological process The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732] stress-activated MAPK cascade biological process A MAPK cascade that starts with the activation of a stress-activated MAP kinase cascade. [GOC:ai, PMID:15936270] limb development biological process The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. [GOC:dgh, GOC:dph, PMID:11487378] cellular response to gamma radiation biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:mah] cellular response to UV-B biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. [GOC:mah] positive regulation of mitotic DNA damage checkpoint biological process Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501] peptidyl-serine phosphorylation biological process The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037] regulation of mitotic metaphase/anaphase transition biological process Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. [GOC:mah] chromosome segregation biological process The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]