methoxsalen has been researched along with Necrosis in 7 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acitretin is currently used alone or combined with PUVA (psoralen + UVA) or with narrow-band ultraviolet B (NBUVB), to treat moderate and severe psoriasis." | 3.79 | Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen-ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients. ( Bronze-da-Rocha, E; Custódio, JB; Fernandes, JC; Figueiredo, A; Moreiras, A; Oliveira, H; Rocha-Pereira, P; Santos-Silva, A; Silva, FS, 2013) |
| "The effect of erythemic UV irradiation on the phototoxic reactions caused by topical methoxsalen + UVA exposure was studied on normal skin, normal-looking skin of vitiligo patients, and vitiliginous skin." | 3.66 | Photoepicutaneous testing. UV-induced protection against photoxic reactions in normal and vitiliginous skin: a clinical and histological study. ( Niemi, KM; Suhonen, R, 1978) |
| "Post-treatment with methoxsalen must be given early and is only partially effective in mice." | 1.27 | The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice. ( Amouyal, G; Carrion-Pavlov, Y; Degott, C; Descatoire, V; Geneve, J; Labbe, G; Larrey, D; Letteron, P; Pessayre, D; Tinel, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silva, FS | 1 |
| Oliveira, H | 1 |
| Moreiras, A | 1 |
| Fernandes, JC | 1 |
| Bronze-da-Rocha, E | 1 |
| Figueiredo, A | 1 |
| Custódio, JB | 1 |
| Rocha-Pereira, P | 1 |
| Santos-Silva, A | 1 |
| Daniele, N | 1 |
| Del Proposto, G | 1 |
| Cerrone, P | 1 |
| Sinopoli, S | 1 |
| Sansone, L | 1 |
| Gadaleta, DI | 1 |
| Lanti, A | 1 |
| Ferraro, AS | 1 |
| Spurio, S | 1 |
| Scerpa, MC | 1 |
| Zinno, F | 1 |
| Adorno, G | 1 |
| Isacchi, G | 1 |
| Bakkali, F | 1 |
| Averbeck, S | 1 |
| Averbeck, D | 1 |
| Zhiri, A | 1 |
| Baudoux, D | 1 |
| Idaomar, M | 1 |
| Ortonne, JP | 1 |
| Schmitt, D | 1 |
| Alario, A | 1 |
| Thivolet, J | 1 |
| Suhonen, R | 1 |
| Niemi, KM | 1 |
| Oesterwitz, H | 1 |
| Gruner, S | 1 |
| Schneider, W | 1 |
| Labbe, G | 1 |
| Descatoire, V | 1 |
| Letteron, P | 1 |
| Degott, C | 1 |
| Tinel, M | 1 |
| Larrey, D | 1 |
| Carrion-Pavlov, Y | 1 |
| Geneve, J | 1 |
| Amouyal, G | 1 |
| Pessayre, D | 1 |
1 trial available for methoxsalen and Necrosis
| Article | Year |
|---|---|
Evaluation of cell death after treatment with extracorporeal photopheresis.
Topics: Adult; Apoptosis; Female; Graft vs Host Disease; Humans; Leukocytes; Male; Methoxsalen; Middle Aged; | 2012 |
6 other studies available for methoxsalen and Necrosis
| Article | Year |
|---|---|
Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen-ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients.
Topics: Acitretin; Apoptosis; Cell Division; Combined Modality Therapy; Comet Assay; Dose-Response Relations | 2013 |
Antigenotoxic effects of three essential oils in diploid yeast (Saccharomyces cerevisiae) after treatments with UVC radiation, 8-MOP plus UVA and MMS.
Topics: Apoptosis; Artemisia; Cell Survival; Cinnamomum camphora; Cytoplasm; Diploidy; Dose-Response Relatio | 2006 |
Oral photochemotherapy in lichen planus (LP) and mycosis fungoides (MF): ultrastructural modifications of the infiltrating cells.
Topics: Cell Nucleus; Cytoplasm; Humans; Lichen Planus; Methoxsalen; Mycosis Fungoides; Necrosis; Photochemo | 1979 |
Photoepicutaneous testing. UV-induced protection against photoxic reactions in normal and vitiliginous skin: a clinical and histological study.
Topics: Humans; Methoxsalen; Necrosis; Photosensitivity Disorders; Skin; Skin Tests; Ultraviolet Rays; Vitil | 1978 |
[Inhibition of rat heart and kidney allograft rejection by photochemical treatment of the recipient].
Topics: Animals; Graft Rejection; Graft Survival; Heart Transplantation; Kidney Transplantation; Methoxsalen | 1990 |
The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochr | 1987 |