Page last updated: 2024-12-06

chlorodibromomethane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Chlorodibromomethane (CHBr2Cl) is a colorless liquid with a sweet odor. It is primarily used as a solvent and reagent in organic synthesis. While its synthesis can be achieved through various methods, it is typically produced by the reaction of methane with bromine and chlorine. Chlorodibromomethane is known to be a potent greenhouse gas, contributing to climate change, and is also classified as a potential human carcinogen due to its ability to damage DNA. Its use is therefore restricted in many applications, and its impact on the environment is actively studied. The study of chlorodibromomethane is essential to understand its environmental impact and develop safer alternatives for its industrial applications.'

Cross-References

ID SourceID
PubMed CID31296
CHEMBL ID157093
CHEBI ID34627
SCHEMBL ID76438
MeSH IDM0101891

Synonyms (54)

Synonym
BIDD:ER0343
AKOS015848668
dibromo(chloro)methane
ccris 938
methane, chlorodibromo-
einecs 204-704-0
brn 1731046
monochlorodibromomethane
cdbm
nci-c55254
hsdb 2763
methane, dibromochloro-
chlorodibromomethane
dibromochloromethane ,
NCGC00091422-01
124-48-1
inchi=1/chbr2cl/c2-1(3)4/h1
dibromochloromethane, analytical standard
dibromochloromethane, 98%
FT-0666487
CHEMBL157093
dibromo-chloro-methane
chebi:34627 ,
S0643
A805237
bis(bromanyl)-chloranyl-methane
NCGC00091422-02
tox21_200153
cas-124-48-1
dtxsid1020300 ,
dtxcid30300
NCGC00257707-01
4-01-00-00081 (beilstein handbook reference)
unii-3t4ajr1h24
3t4ajr1h24 ,
FT-0623638
chlorodibromomethane [iarc]
chlorodibromomethane [hsdb]
chlorobromoform
chlorodibromomethane [mi]
SCHEMBL76438
dibromomonochloromethane
GATVIKZLVQHOMN-UHFFFAOYSA-N
chclbr2
J-005082
mfcd00000820
dibromochloromethane, analytical standard, amylene stabilized
dibromochloromethane 100 microg/ml in methanol
chlorodibromomethane; dbcm; dibromomonochloromethane; monochlorodibromomethane
dibromochloromethane (stabilized with ethanol)
Q411773
FS-3822
D89312
CS-0315221

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Based on the results of this study, the (LOAEL) lowest observed adverse effect level for DCBM when administered to Sprague-Dawley rats in corn oil gavage was 50 mg."( Ninety-day oral toxicity study of dibromochloromethane in Sprague-Dawley rats.
Condie, LW; Daniel, FB; Robinson, M; York, RG, 1990
)
0.28
" No adverse effects on survival in treated rats were observed."( Toxicity and carcinogenicity of chlorodibromomethane in Fischer 344/N rats and B6C3F1 mice.
Dunnick, JK; Haseman, JK; Lilja, HS; Wyand, S, 1985
)
0.55
" One of the important issues considering ballast water treatment is to determine whether treated ballast water, once discharged, is safe to the aquatic environment."( Acute and chronic toxicity of selected disinfection byproducts to Daphnia magna, Cyprinodon variegatus, and Isochrysis galbana.
Burton, D; Fisher, D; Friedel, E; Yonkos, L; Ziegler, G, 2014
)
0.4

Pharmacokinetics

ExcerptReferenceRelevance
" The metabolic elimination amounts at various exposure concentrations were extrapolated using the estimated pharmacokinetic parameters."( Estimation of absorption of trihalomethanes and carbon tetrachloride in low-level exposure by inhalation pharmacokinetic analysis in rats.
Andoh, K; Fukuhara, M; Yoshida, T, 1999
)
0.3
" The significant increase in blood concentrations of THMs could be a consequence of pharmacokinetic interactions between two or more of the THMs present simultaneously."( Evaluation of the pharmacokinetic interactions between orally administered trihalomethanes in the rat.
Charest-Tardif, G; Da Silva, ML; Krishnan, K; Tardif, R, 2000
)
0.31
" To use biomonitoring data in understanding exposure, physiologically based pharmacokinetic (PBPK) modeling can be used in a reverse dosimetry approach to assess a distribution of exposures possibly associated with specific blood or urine levels of compounds."( Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling.
Clewell, HJ; Liao, KH; Tan, YM, 2007
)
0.34

Bioavailability

ExcerptReferenceRelevance
" Trihalomethanes are well absorbed by the oral route which was selected for this study as being that most relevant to humans."( Assessment of the potential in vivo genotoxicity of three trihalomethanes: chlorodibromomethane, bromodichloromethane and bromoform.
Howard, WR; Proudlock, RJ; Statham, J; Stocker, KJ, 1997
)
0.53

Dosage Studied

ExcerptRelevanceReference
" A dosing accident rendered the number of low-dose male mice inadequate for statistical analysis."( Toxicity and carcinogenicity of chlorodibromomethane in Fischer 344/N rats and B6C3F1 mice.
Dunnick, JK; Haseman, JK; Lilja, HS; Wyand, S, 1985
)
0.55
" The potentiated response observed with acetone plus BrCHCl2 or Br2CHCl was equal to or greater than that observed with acetone plus an approximately equimolar dosage of CHCl3."( Acetone-induced potentiation of trihalomethane toxicity in male rats.
Brown, EM; Hewitt, WR; Plaa, GL, 1983
)
0.27
" This study compares dose-response relationships of gavage-administered chlorinated/brominated trihalomethanes for hepatotoxicity, replicative DNA synthesis, and hepatocarcinogenicity in female B6C3F1 mice."( Regenerative hyperplasia is not required for liver tumor induction in female B6C3F1 mice exposed to trihalomethanes.
Dunnick, JK; Kohn, MC; Leininger, JR; Melnick, RL, 1998
)
0.3
" Suggestive dose-response relationships were also observed between elevated blood TCM or ∑ THMs (sum of TCM, BDCM, DBCM and TBM) concentration and decreased sperm concentration (both p for trend=0."( Baseline blood trihalomethanes, semen parameters and serum total testosterone: a cross-sectional study in China.
Cao, WC; Gu, LJ; Li, M; Li, YF; Liu, AL; Lu, WQ; Xie, SH; Yue, J; Zeng, Q; Zheng, D, 2013
)
0.39
" The association was further confirmed in the cubic spline model, and a linear dose-response relationship was observed."( First-trimester blood concentrations of drinking water trihalomethanes and neonatal neurobehavioral development in a Chinese birth cohort.
Ai, SH; Chen, YJ; Cheng, YH; Huang, LL; Huang, Z; Lei, HS; Li, J; Liu, C; Liu, J; Liu, XY; Liu, YA; Lu, WQ; Pan, A; Sun, L; Wang, X; Wang, YX, 2019
)
0.51
" Additionally, we found positive dose-response relationships between blood BDCM, DBCM, and Br-THM concentrations and serum markers of oxidative stress (i."( Blood Trihalomethane Concentrations and Osteoarthritis among U.S. Population Aged over 50 Years.
Messerlian, C; Mustieles, V; Qian, D; Sun, Y; Wang, YX; Zhang, Y, 2023
)
0.91
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, HADH2 proteinHomo sapiens (human)Potency31.62280.025120.237639.8107AID886
Chain B, HADH2 proteinHomo sapiens (human)Potency31.62280.025120.237639.8107AID886
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.50120.000214.376460.0339AID588532
farnesoid X nuclear receptorHomo sapiens (human)Potency0.00320.375827.485161.6524AID588527
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency15.31250.000323.4451159.6830AID743065; AID743067
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID37562Induction of aneuploidy in Aspergillus nidulans.1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
Molecular similarity matrices and quantitative structure-activity relationships: a case study with methodological implications.
AID19825Partition coefficient (logP)1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
Molecular similarity matrices and quantitative structure-activity relationships: a case study with methodological implications.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (87)

TimeframeStudies, This Drug (%)All Drugs %
pre-199017 (19.54)18.7374
1990's24 (27.59)18.2507
2000's14 (16.09)29.6817
2010's25 (28.74)24.3611
2020's7 (8.05)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 41.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index41.72 (24.57)
Research Supply Index4.51 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index59.85 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (41.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (3.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other87 (96.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]