ukrain profile

ukrain: a phytogenic antineoplastic agent; semisynthetic product from alkaloids of Chelidonium majus L. & thiophosphoric triaciridide acid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Chelidonium	genus	A plant genus in the family PAPAVERACEAE, order Papaverales, subclass Magnoliidae.[MeSH]	Papaveraceae	The poppy plant family of the order Papaverales, subclass Magnoliidae, class Magnoliopsida. These have bisexual, regular, cup-shaped flowers with one superior pistil and many stamens; 2 or 3 conspicuous, separate sepals and a number of separate petals. The fruit is a capsule. Leaves are usually deeply cut or divided into leaflets.[MeSH]
Chelidonium majus	species	[no description available]	Papaveraceae	The poppy plant family of the order Papaverales, subclass Magnoliidae, class Magnoliopsida. These have bisexual, regular, cup-shaped flowers with one superior pistil and many stamens; 2 or 3 conspicuous, separate sepals and a number of separate petals. The fruit is a capsule. Leaves are usually deeply cut or divided into leaflets.[MeSH]

ID Source	ID
PubMed CID	160027
MeSH ID	M0169036

Synonym
ukrain
nsc-631570
uksr-222
ccris 6300
138069-52-0
ukrain compound
unii-6251q9uk1s
6251q9uk1s ,
chelidoninium, 5,5',5''-(phosphinothioylidynetris(imino-2,1-ethanediyl))tris(5-methyl-, trihydroxide
Q502728
[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13,13',13''-[phosphinothioylidynetris(imino-2,1-ethanediyl)]tris[5b,6,7,12b,13,14-hexahydro-6-hydroxy-13-methyl-, hydroxide (1:3), (5br,5'br,5''br,6s,6's,6''s,12bs,12'bs,12''bs)-

Excerpt	Reference	Relevance
"Ukrain (NSC 631570) is a synthetic thiophosphate derivative of alkaloids from the extract of the celandine (Chelidonium majus L.) plant."	( Ukrain (NSC 631570) ameliorates intestinal ischemia-reperfusion-induced acute lung injury by reducing oxidative stress. Akcilar, A; Akcilar, R; Bayat, Z; Bayhan, Z; Kocak, C; Kocak, FE; Savran, B; Zeren, S, 2016)	2.6
"Ukrain (NSC-631570) is a cytostatic and immunomodulating semisynthetic compound of thiophosphate-modified alkaloids of Chelidonium majus L. "	( Comparative investigation of the effect of ukrain on growth of ascites and solid forms of Ehrlich's carcinoma. Liubunya, AV; Pozur, VV; Rudik, MP; Skivka, LM; Susak, YM, 2010)	2.07
"Ukrain is a reaction product of different alkaloids from Chelidoniummajus L."	( Effect of ukrain on cell survival and apoptosis in the androgen-independent prostate cancer cell line PC-3. Govindaraj, S; Jagadeesan, A; Kalimuthu, S; Perumal, E; Ramachandran, A; Velayutham, S; Venkatesh, K, 2011)	1.49
"Ukrain is an anticancer drug based on the extract of the plant Chelidonium majus L. "	( Ukrain - a new cancer cure? A systematic review of randomised clinical trials. Ernst, E; Schmidt, K, 2005)	3.21
"Ukrain turned out to be a potent inducer of apoptosis. "	( Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. Bamberg, M; Belka, C; Cordes, N; Daniel, PT; Eldh, T; Gruber, C; Habermehl, D; Handrick, R; Jendrossek, V; Kammerer, B; Plasswilm, L, 2006)	2.08
"Ukrain is a reaction product of different alkaloids from Chelidonium majus L. "	( NF-kappaB does not influence the induction of apoptosis by Ukrain. Aldana, A; Ceballos, G; Espinosa, M; Gallardo, JC; Maldonado, V; Melendez-Zajgla, J; Mendoza, J; Zamora, R, 2006)	2.02
"Ukrain is a semisynthetic compound consisting of alkaloids from Chelidonium majus L. "	( Modulation of immune effector cell cytolytic activity and tumour growth inhibition in vivo by Ukrain (NSC 631570). Liepins, A; Nowicky, JW, 1996)	1.96
"Ukrain is a new effective drug in the therapy of colorectal cancer."	( Comparison of chemotherapy and X-ray therapy with Ukrain monotherapy for colorectal cancer. Korsh, OB; Kravchenco, OB; Susak, YM; Yaremchuk, OY; Yatsyk, IM; Zemskov, VS, 1996)	1.27
"Ukrain is a semisynthetic drug with immunomodulatory properties derived from Chelidonium majus L. "	( Estimation of direct influence of Ukrain preparation on influenza viruses and the bacteria E. coli and S. aureus. Ciebiada, I; Denys, A; Korczak, E; Nowicky, JW, 1996)	2.02
"Ukrain was proved to be an effective antitumor agent on biological and mathematical models in accordance with standardized instructions for screening."	( Morphometric and kinetic analysis of the growth of experimental sarcoma-45 in the presence of Ukrain. Deneka, ER, 1998)	1.24
"Ukrain is a promising drug proved to be efficient in the treatment of different tumors when used either before, during or after radiation therapy."	( A comparative evaluation of the influence of the complex drug Ukrain and its components on the effects of radiation. Boyko, VN; Zholus, RB, 1998)	1.26
"Ukrain is alleged to be an effective chemotherapeutic drug which causes minimal side-effects as a result of selective toxicity towards malignant cells only. "	( The antimitotic effects of Ukrain, a Chelidonium majus alkaloid derivative, are reversible in vitro. Bianchi, PC; Joubert, AM; Panzer, A; Seegers, JC, 2000)	2.05
"Ukrain is a semisynthetic drug with immunomodulatory properties, derived from Chelidonium majus L. "	( Enhancement of macrophage tumouricidal activity by the alkaloid derivative Ukrain. In vitro and in vivo studies. Liepins, A; Lopez, DM; Rao, K; Sotomayor, EM, 1992)	1.96
"Ukrain is a semisynthetic compound consisting of alkaloids from Chelidonium majus L. "	( Activation of spleen cell lytic activity by the alkaloid thiophosphoric acid derivative: Ukrain. Liepins, A; Nowicky, JW, 1992)	1.95

Excerpt	Reference	Relevance
"Ukrain has been demonstrated to possess antineoplastic and immunomodulatory properties."	( Ukrain (NSC-631570) in experimental and clinical studies: a review. Jagiello-Wójtowicz, E; Kleinrok, Z; Urbanska, EM, 1998)	2.46
"Ukrain(TM) has been described as a semisynthetic Chelidonium majus alkaloid derivative, which exhibits selective toxicity towards malignant cells only. "	( Ukrain(TM), a semisynthetic Chelidonium majus alkaloid derivative, acts by inhibition of tubulin polymerization in normal and malignant cell lines. Bianchi, PC; Hamel, E; Joubert, AM; Panzer, A; Seegers, JC, 2000)	3.19
"Ukrain has been described as a semi-synthetic Chelidonium majus alkaloid derivative, consisting of three chelidonine alkaloids combined to triaziridide. "	( Chemical analyses of Ukrain, a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure. Albrecht, CF; Eloff, JN; Erasmus, E; Joubert, AM; Panzer, A; Seegers, JC, 2000)	2.07
"Ukrain has previously been demonstrated to exert a malignotoxic effect in vivo. "	( Chitotriosidase as a new marker of macrophage stimulation in a tumor model treated with cyclophosphamide and Ukrain. Buzueva, II; Djanayeva, SJ; Falameyeva, OV; Filjushina, EE; Kaledin, VI; Korolenko, TA; Nowicky, J; Sandula, J; Wevers, RA, 2000)	1.96
"(Ukrain) has been produced since 1978 by Nowicky."	( In vitro effects of Chelidonium majus L. alkaloid thiophosphoric acid conjugates (Ukrain) on the phenotype of normal human lymphocytes. Harłozinska, A; Nowicky, JW; Slesak, B, 1992)	1.13

Excerpt	Reference	Relevance
"Ukrain was found to increase the survival rate of mice by 50-60 percent at irradiation doses from 6.00 to 6.75 Gy with no effect at the dose of 7.5 Gy."	( Action of Ukrain, a cytostatic and immunomodulating drug, on effects of irradiation. Boyko, VN; Bubnov, VP; Petrov, AS; Voltchek, IV, 1996)	1.42

Excerpt	Reference	Relevance
"Ukrain treatment was well tolerated. "	( Efficacy of ukrain in the treatment of pancreatic cancer. Hodysh, Y; Nowicky, W; Prokopchuk, O; Susak, Y; Tkachenko, O; Zemskov, S; Zemskov, V, 2002)	2.14
"Ukrain treatment was well tolerated."	( Ukrain (NSC-631570) in the treatment of pancreas cancer. Hodysh, YY; Procopchuk, OL; Susak, YM; Zemskov, SV; Zemskov, VS; Zemskova, MV, 2000)	2.47
"Ukrain treatment was well tolerated by the patient and there were no complications in the postoperative period."	( Ukrain treatment of a patient with retroperitoneal synovial sarcoma. Case report. Prokopchuk, OL; Susak, YM; Zemskov, SV, 2000)	2.47
"Ukrain treatment of LS lymphosarcoma was also followed by increased levels of cystatin C in tumor tissue (4-fold); cyclophosphane plus Ukrain had a similar positive effect."	( Cysteine proteinase inhibitor level in tumor and normal tissues in control and cured mice. Djanayeva, SJ; Falameyeva, OV; Kaledin, VI; Korolenko, TA; Nowicky, JW; Poteryaeva, ON; Sandula, J, 2000)	1.03
"Treatment with Ukrain was without serious negative effects and the number of side effects of IFN in individual therapy was significantly reduced."	( Preliminary results of individual therapy of chronic hepatitis C by Ukrain and interferon-alpha. Belopolskaya, M; Belozyorova, L; Grigoryeva, T; Lamanova, E; Nowicky, JW; Semenyako, N; Sologub, T; Voltchek, I, 2000)	0.88

Excerpt	Reference	Relevance
" Morphological studies of toxic changes in 40 different organs of rats were performed on macro- and microscopic levels."	( Study of acute toxicity of Ukrain in rats after intravenous injection. Deneka, ER; Karmozina, LG; Kulik, GI; Todor, IN, 1998)	0.6
" It was found that the intravenous LD50 was greater than 43 mg active ingredient/kg body weight in the males and 76 mg active ingredient/kg body weight in the females."	( Ukrain: acute toxicity after intravenous, intramuscular and oral administration in rats. Hruby, R, 2000)	1.75

Excerpt	Reference	Relevance
"To carry out comparative investigation of the effect of Ukrain used alone and in combination with pathogen associated molecules (PAM) on mitotic cycle and apoptosis induction in mouse melanoma cell lines with different biological properties."	( The effect of NSC-631570 (ukrain) alone and in combination with pathogen-associated molecules on cell cycle distribution and apoptosis induction of mouse melanoma cells with different biological properties. Bezdenezhnykh, NA; Kudryavets, YI; Skivka, LM; Susak, YM; Trompak, OO, 2010)	0.91

Excerpt	Relevance	Reference
" A clear dose-response effect was found for Ukrain."	( Influence of Ukrain on human xenografts in vitro. Hiesmayr, W; Liepins, A; Nowicky, JW; Nowicky, W, 1996)	0.92
" The interrelation between toxicity (death of animals) and dosage was determined by nonlinear regression method."	( Study of acute toxicity of Ukrain in rats after intravenous injection. Deneka, ER; Karmozina, LG; Kulik, GI; Todor, IN, 1998)	0.6
" The rate of apoptotic cells rose steadily with increased drug concentration in a dose-dependent manner and reached 20% at a dosage of 17."	( Induced apoptosis in human prostate cancer cell line LNCaP by Ukrain. Haake, AR; Ludlow, JW; Polevoda, BV; Roublevskaia, IN, 2000)	0.55
" Dosage range, methods of introduction and duration of administration of the drug vary."	( Comparative investigation of the effect of ukrain on growth of ascites and solid forms of Ehrlich's carcinoma. Liubunya, AV; Pozur, VV; Rudik, MP; Skivka, LM; Susak, YM, 2010)	0.62

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (0.58)	18.7374
1990's	94 (54.65)	18.2507
2000's	52 (30.23)	29.6817
2010's	20 (11.63)	24.3611
2020's	5 (2.91)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	23 (12.64%)	5.53%
Reviews	4 (2.20%)	6.00%
Case Studies	21 (11.54%)	4.05%
Observational	0 (0.00%)	0.25%
Other	134 (73.63%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.38	2	0	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2	1	0	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
succinic acid Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851). succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.	1.99	1	0	alpha,omega-dicarboxylic acid; C4-dicarboxylic acid	anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	2.15	1	0	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
hydroxyindoleacetic acid (5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.	1.98	1	0	indole-3-acetic acids	drug metabolite; human metabolite; mouse metabolite
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	4.34	2	2	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
sanguinarine benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.	7.02	1	0	alkaloid antibiotic; benzophenanthridine alkaloid; botanical anti-fungal agent
thiotepa Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).	2.69	3	0	aziridines
corticosterone [no description available]	1.99	1	0	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	2	1	0	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
aldosterone [no description available]	1.99	1	0	11beta-hydroxy steroid; 18-oxo steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid hormone; mineralocorticoid; primary alpha-hydroxy ketone; steroid aldehyde	human metabolite; mouse metabolite
triiodothyronine Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	2	1	0	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine	human metabolite; mouse metabolite; thyroid hormone
aminopyrine Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.. aminophenazone : A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.	1.98	1	0	pyrazolone; tertiary amino compound	antipyretic; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	2.1	1	0	diazine; pyrazines	Daphnia magna metabolite
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.15	1	0	dialdehyde	biomarker
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	7.15	1	0	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
deoxycytidine [no description available]	3.39	1	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
acetylthiocholine Acetylthiocholine: An agent used as a substrate in assays for cholinesterases, especially to discriminate among enzyme types.	2	1	0
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.38	2	0	benzenes; phenyl acetates
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.25	1	0	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	7	1	0	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
ng-nitroarginine methyl ester NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.	1.99	1	0	alpha-amino acid ester; L-arginine derivative; methyl ester; N-nitro compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor
gemcitabine gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.	3.39	1	1	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic
methotrexate [no description available]	1.99	1	0	dicarboxylic acid; monocarboxylic acid amide; pteridines	abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent
omega-n-methylarginine omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.	1.99	1	0	amino acid zwitterion; arginine derivative; guanidines; L-arginine derivative; non-proteinogenic L-alpha-amino acid
thiophosphoric acid thiophosphoric acid: RN given refers to parent cpd	7.01	1	0	phosphorothioic acid
bortezomib [no description available]	7.1	1	0	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor
nadp [no description available]	1.99	1	0
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	7.39	2	0
bilirubin [no description available]	2.15	1	0	biladienes; dicarboxylic acid	antioxidant; human metabolite; mouse metabolite
morphine Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.	2.68	3	0	morphinane alkaloid; organic heteropentacyclic compound; tertiary amino compound	anaesthetic; drug allergen; environmental contaminant; geroprotector; mu-opioid receptor agonist; opioid analgesic; plant metabolite; vasodilator agent; xenobiotic
cesium Cesium: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.	2.01	1	0	alkali metal atom
naltrexone Naltrexone: Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.. naltrexone : An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.	6.99	1	0	cyclopropanes; morphinane-like compound; organic heteropentacyclic compound	antidote to opioid poisoning; central nervous system depressant; environmental contaminant; mu-opioid receptor antagonist; xenobiotic
selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	7.21	1	0	chalcogen; nonmetal atom	micronutrient
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	2.15	1	0	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent
losartan potassium Erythropoietin: Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.	2	1	0
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	3.79	2	1	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2.25	1	0
dacarbazine (E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.	1.99	1	0	dacarbazine

Condition	Relationship Strength	Studies	Trials
Carcinoma, Epidermoid [description not available]	2.7	3	0
Cancer of Head [description not available]	2.25	1	0
Angiogenesis, Pathologic [description not available]	2.25	1	0
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	2.7	3	0
Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)	2.25	1	0
Injuries, Radiation [description not available]	2.25	1	0
Anxiety Neuroses [description not available]	2.25	1	0
Anxiety Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.	2.25	1	0
Anxiety Disorders Persistent and disabling ANXIETY.	2.25	1	0
Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	2.25	1	0
Breast Cancer [description not available]	8.83	21	11
B16 Melanoma [description not available]	7.48	2	0
Breast Neoplasms Tumors or cancer of the human BREAST.	8.83	21	11
Injury, Ischemia-Reperfusion [description not available]	2.81	3	0
Intestinal Diseases Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.	2.11	1	0
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.81	3	0
Lung Injury, Acute [description not available]	2.13	1	0
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	7.13	1	0
Acute Kidney Failure [description not available]	2.13	1	0
Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.	2.13	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.15	1	0
Acute Edematous Pancreatitis [description not available]	2.15	1	0
Pancreatitis INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.	7.15	1	0
Marfan Syndrome, Type I [description not available]	2.13	1	0
Marfan Syndrome An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome (type 1) is associated with mutations in the gene encoding FIBRILLIN-1 (FBN1), a major element of extracellular microfibrils of connective tissue. Mutations in the gene encoding TYPE II TGF-BETA RECEPTOR (TGFBR2) are associated with Marfan syndrome type 2.	7.13	1	0
Malignant Melanoma [description not available]	3.24	6	0
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	3.24	6	0
Carcinoma, Ehrlich Tumor A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.	2.41	2	0
Adenocarcinoma, Basal Cell [description not available]	4.76	7	1
Cancer of Pancreas [description not available]	6.14	6	2
Invasiveness, Neoplasm [description not available]	2.74	3	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	4.76	7	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	6.14	6	2
B-Cell Chronic Lymphocytic Leukemia [description not available]	2.07	1	0
Leukemia, Lymphocytic, Chronic, B-Cell A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.	2.07	1	0
Cancer of Prostate [description not available]	4.09	3	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	4.09	3	1
Adenocarcinoma Of Kidney [description not available]	2.43	2	0
Cancer of Kidney [description not available]	2.43	2	0
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	2.43	2	0
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2.43	2	0
Carcinoma, Ductal, Pancreatic [description not available]	2.07	1	0
Carcinoma, Pancreatic Ductal Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.	2.07	1	0
Experimental Mammary Neoplasms [description not available]	2.69	3	0
Benign Neoplasms [description not available]	7.72	15	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	7.72	15	2
Cancer of Lung [description not available]	3.25	6	0
Lung Neoplasms Tumors or cancer of the LUNG.	3.25	6	0
Carcinoma, Lewis Lung A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.	2.02	1	0
Bladder Cancer [description not available]	10	3	1
Colorectal Cancer [description not available]	9.99	3	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	5	3	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	4.99	3	1
Benign Neoplasms, Brain [description not available]	2.71	3	0
Astrocytoma, Grade IV [description not available]	2.44	2	0
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.71	3	0
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	2.44	2	0
Ewing Sarcoma [description not available]	2.69	3	0
Sarcoma, Ewing A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.	2.69	3	0
Di Guglielmo Disease [description not available]	1.99	1	0
Leukemia, Erythroblastic, Acute A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.	1.99	1	0
Germinoblastoma [description not available]	1.99	1	0
Kahler Disease [description not available]	1.99	1	0
Experimental Neoplasms [description not available]	3.24	6	0
Reticulum Cell-Like Sarcoma, Yoshida [description not available]	1.99	1	0
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	1.99	1	0
Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	1.99	1	0
Experimental Leukemia [description not available]	1.99	1	0
Mast-Cell Sarcoma A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.	1.99	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	4.64	6	1
Age-Related Osteoporosis [description not available]	2.68	3	0
Osteoporosis Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.	2.68	3	0
Cancer of Colon [description not available]	2.39	2	0
EHS Tumor [description not available]	2.4	2	0
Colonic Neoplasms Tumors or cancer of the COLON.	2.39	2	0
Anaphylactic Reaction [description not available]	2.39	2	0
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	2.39	2	0
E coli Infections [description not available]	1.99	1	0
Infections, Staphylococcal [description not available]	1.99	1	0
Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI.	1.99	1	0
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	1.99	1	0
Infections, Orthomyxoviridae [description not available]	2.39	2	0
Orthomyxoviridae Infections Virus diseases caused by the ORTHOMYXOVIRIDAE.	2.39	2	0
Pneumonia, Viral Inflammation of the lung parenchyma that is caused by a viral infection.	1.99	1	0
Local Neoplasm Recurrence [description not available]	2.9	4	0
Lymph Node Metastasis [description not available]	1.99	1	0
Cancer of Muscle [description not available]	1.99	1	0
Rhabdomyosarcoma A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)	6.99	1	0
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	3.77	2	1
Cancer of Ovary [description not available]	2.39	2	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.39	2	0
Carcinoma, Intraepithelial [description not available]	1.99	1	0
Cervix Dysplasia [description not available]	1.99	1	0
Cancer of Cervix [description not available]	2.39	2	0
Carcinoma in Situ A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.	1.99	1	0
Uterine Cervical Dysplasia Abnormal development of immature squamous EPITHELIAL CELLS of the UTERINE CERVIX, a term used to describe premalignant cytological changes in the cervical EPITHELIUM. These atypical cells do not penetrate the epithelial BASEMENT MEMBRANE.	1.99	1	0
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	2.39	2	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.67	3	0
Germinoma A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)	1.99	1	0
Cancer of Testis [description not available]	1.99	1	0
Testicular Neoplasms Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.	1.99	1	0
Cancer of Esophagus [description not available]	1.99	1	0
Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS.	1.99	1	0
Cancer of the Urethra [description not available]	1.99	1	0
Urethral Neoplasms Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.	1.99	1	0
Anaplastic Astrocytoma [description not available]	2.39	2	0
Astrocytoma Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)	2.39	2	0
Cranial Nerve II Diseases [description not available]	1.99	1	0
Benign Cranial Nerve Neoplasms [description not available]	1.99	1	0
Optic Nerve Diseases Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.	1.99	1	0
Acquired Immune Deficiency Syndrome [description not available]	1.99	1	0
Kaposi Sarcoma [description not available]	1.99	1	0
Acquired Immunodeficiency Syndrome An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.	1.99	1	0
Sarcoma, Kaposi A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.	1.99	1	0
Cancer of Rectum [description not available]	3.38	1	1
Rectal Neoplasms Tumors or cancer of the RECTUM.	3.38	1	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	6.99	1	0
Experimental Hepatoma [description not available]	2.91	4	0
Francisella tularensis Infection [description not available]	1.99	1	0
Tularemia A plague-like disease of rodents, transmissible to man. It is caused by FRANCISELLA TULARENSIS and is characterized by fever, chills, headache, backache, and weakness.	1.99	1	0
Weight Gain Increase in BODY WEIGHT over existing weight.	2.39	2	0
Carcinosarcoma A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)	2	1	0
Complication, Postoperative [description not available]	3.39	1	1
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	3.39	1	1
Carcinoma, Anaplastic [description not available]	2.39	2	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	7.39	2	0
Synovioma [description not available]	2	1	0
Retroperitoneal Neoplasms New abnormal growth of tissue in the RETROPERITONEAL SPACE.	2	1	0
Sarcoma, Synovial A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)	2	1	0
Neoplasms, Vascular [description not available]	2	1	0
Chronic Hepatitis C [description not available]	8.39	1	1
Hepatitis C, Chronic INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.	3.39	1	1
Diffuse Mixed Small and Large Cell Lymphoma [description not available]	2.92	4	0
Lymphoma, Non-Hodgkin Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.	2.92	4	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2	1	0
Osteogenic Sarcoma [description not available]	1.98	1	0
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	1.98	1	0
Ache [description not available]	4.06	3	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	4.06	3	1
Absence Seizure [description not available]	1.98	1	0
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	6.98	1	0
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	1.98	1	0
Neoplasms, Bronchial [description not available]	1.98	1	0
Cancer of Skin [description not available]	1.98	1	0
Cancer of the Uterus [description not available]	1.98	1	0
Bronchial Neoplasms Tumors or cancer of the BRONCHI.	1.98	1	0
Skin Neoplasms Tumors or cancer of the SKIN.	1.98	1	0
Uterine Neoplasms Tumors or cancer of the UTERUS.	1.98	1	0
Bone Cancer [description not available]	1.98	1	0
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	1.98	1	0
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	1.98	1	0

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