Erythromycin is a macrolide antibiotic that is effective against a wide range of bacteria. It was first isolated from the bacterium Saccharopolyspora erythraea in 1952. Erythromycin is typically produced by fermentation, where S. erythraea is grown in large tanks containing nutrients. The fermentation process yields erythromycin in the form of a complex mixture of related compounds. Erythromycin is effective against many gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae, and some gram-negative bacteria, such as Haemophilus influenzae. Erythromycin works by inhibiting the synthesis of proteins in bacterial cells, thus preventing the bacteria from multiplying. It is used to treat a variety of bacterial infections, including pneumonia, bronchitis, skin infections, and ear infections. Erythromycin is also used to prevent bacterial infections in people who are at risk, such as those undergoing surgery or those with weakened immune systems. Erythromycin is generally well-tolerated, but some people experience side effects, such as nausea, vomiting, diarrhea, and abdominal pain. Erythromycin is a potent antibiotic, but it is not a cure-all for all bacterial infections. Erythromycin can be an effective treatment for many bacterial infections. It works by preventing bacteria from multiplying, which can help to stop the infection from spreading. Erythromycin is a valuable tool in the fight against bacterial infections, and research continues to explore its potential applications in medicine and other fields.'
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 12560 |
| CHEMBL ID | 532 |
| CHEBI ID | 42355 |
| CHEBI ID | 48923 |
| SCHEMBL ID | 2601 |
| MeSH ID | M0007715 |
| Synonym |
|---|
| AC-12744 |
| BIDD:GT0017 |
| em-a |
| gtpl1456 |
| (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione |
| DIVK1C_000294 |
| KBIO1_000397 |
| KBIO1_000702 |
| DIVK1C_000397 |
| DIVK1C_000702 |
| KBIO1_000294 |
| eryacne |
| (3r*,4s*,5s*,6r*,7r*,9r*,11r*,12r*,13s*,14r*)-4-((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyl)oxy)-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl)oxy)oxacyclotetradecane |
| nsc 55929 |
| erimycin-t |
| e-base |
| erygel |
| ery-maxin |
| erydermer |
| ai3-50138 |
| deripil |
| pantoderm |
| e-mycin (base) |
| eros |
| ery-b |
| a/t/s |
| erytab |
| erythroderm |
| aknederm ery gel |
| erecin |
| aknemycin |
| mercina |
| endoeritrin |
| hsdb 3074 |
| erythro-statin |
| eritrocina |
| pharyngocin |
| erythromycinum [inn-latin] |
| acneryne |
| oftamolets |
| t-stat |
| skid gel e |
| erymed |
| sansac |
| eritomicina |
| erythra-derm |
| proterytrin |
| akne-mycin |
| ak-mycin |
| sans-acne |
| emycin |
| mephamycin |
| austrias |
| ery-tab |
| tiprocin |
| ery-tab (base) |
| derimer |
| primacine |
| pantodrin |
| dumotrycin |
| erycette |
| inderm |
| e-glades |
| c-solve-2 |
| erysafe |
| wemid |
| emu-v |
| del-mycin |
| stiemycin |
| eryc 125 |
| stiemicyn |
| eritromicina [inn-spanish] |
| erythromycin base |
| eryc-125 |
| udima ery gel |
| latotryd |
| erythromycine [inn-french] |
| r-p mycin |
| eryhexal |
| akne cordes losung |
| oftalmolosa cusi eritromicina |
| iloticina |
| ccris 9078 |
| eryc sprinkles |
| erytrociclin |
| e-base (base) |
| erythromast 36 |
| lederpax |
| erycen |
| pce dispertab (base) |
| eryacnen |
| e-solve 2 |
| erisone |
| erytop |
| romycin |
| emu-ve |
| ermycin |
| emuvin |
| acnesol |
| erythro-teva |
| ery-diolan |
| einecs 204-040-1 |
| eryc (base) |
| theramycin z |
| ilosone (estolate) |
| inderm gel |
| aknin |
| eryc-250 |
| propiocine |
| ilocaps |
| erycinum |
| eryc |
| kesso-mycin |
| nsc-55929 |
| abboticin |
| pantomicina |
| eryderm |
| erycin |
| dotycin |
| erythromid |
| taimoxin-f |
| t-stat (tn) |
| D00140 |
| pce (tn) |
| erythromycin (jp17/usp/inn) |
| eryc (tn) |
| erygel (tn) |
| staticin (tn) |
| akne-mycin (tn) |
| SPECTRUM_000115 |
| SPECTRUM_000659 |
| benzamycin |
| torlamicina |
| robimycin |
| ilotycin |
| e-mycin |
| staticin |
| erythrocin |
| retcin |
| PRESTWICK_205 |
| cas-114-07-8 |
| BSPBIO_002480 |
| IDI1_000397 |
| NCGC00179619-01 |
| erythroguent |
| erythrogran |
| emgel |
| nsc55929 |
| (3r*,4s*,5s*,6r*,7r*,9r*,11r*,12r*,13s*,14r*)-4-[(2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3- |
| erymax |
| (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetr |
| SPECTRUM5_001596 |
| BPBIO1_000312 |
| IDI1_000294 |
| PRESTWICK3_000151 |
| erythro |
| ERY , |
| C01912 |
| erythromycin |
| abomacetin |
| erythromycin a |
| 114-07-8 |
| erythromycin, biotechnology performance certified |
| erythromycin, potency: >=850 mug per mg |
| erythromycin, bioreagent, suitable for cell culture |
| erythromycin, meets usp testing specifications |
| DB00199 |
| IDI1_000702 |
| SMP1_000119 |
| NCGC00094670-01 |
| KBIO2_005691 |
| KBIO2_003707 |
| KBIOSS_001139 |
| KBIOGR_001175 |
| KBIO2_000555 |
| KBIO2_006275 |
| KBIO2_003123 |
| KBIOSS_000555 |
| KBIO2_001139 |
| NINDS_000702 |
| SPECTRUM4_000538 |
| SPECTRUM2_000759 |
| SPECTRUM2_001263 |
| NINDS_000397 |
| SPBIO_001226 |
| NINDS_000294 |
| SPBIO_000778 |
| SPECTRUM1500280 |
| BSPBIO_000282 |
| eritromicina |
| CHEBI:42355 , |
| smr000544946 |
| MLS001066618 |
| erythromycinum |
| (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-4-(2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-6-[3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione |
| (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-{[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxa |
| erthromycin |
| erythromycine |
| LMPK04000006 |
| HMS2091D05 |
| e0751 , |
| erythromycin-a |
| (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
| CHEMBL532 , |
| erythromycin estolate impurity, free erythromycin- |
| j01fa01 |
| HMS500O16 |
| HMS1920M04 |
| NCGC00179619-03 |
| NCGC00179619-02 |
| HMS2095O04 |
| sentry aq mardel maracyn |
| ec 204-040-1 |
| erythromycin [usp:inn:ban:jan] |
| unii-63937kv33d |
| 63937kv33d , |
| ilotycin t.s. |
| NCGC00254234-01 |
| tox21_111869 |
| tox21_300515 |
| bdbm50344942 |
| nsc-756759 |
| nsc756759 |
| pharmakon1600-01500280 |
| dtxsid4022991 , |
| dtxcid102991 |
| tox21_111311 |
| CCG-38992 |
| erythromycin, n-demethyl-n-(methyl-11c)- |
| 82343-12-2 |
| n-methylerythromycin a |
| erythromycin [jan] |
| erythromycin [who-ip] |
| erythromycin [mi] |
| erythromycin [green book] |
| erythromycinum [who-ip latin] |
| erythromycin [who-dd] |
| erythromycin [vandf] |
| pce (erythromycin) |
| erythromycin component of benzamycin |
| erythromycin [usp-rs] |
| erythromycin [orange book] |
| benzamycin component erythromycin |
| erythromycin [usp monograph] |
| erythromycin estolate impurity, free erythromycin- [usp impurity] |
| erythromycin estolate impurity, free erythromycin [ep impurity] |
| erythromycin [hsdb] |
| erythromycin [ep monograph] |
| erythromycin [inn] |
| erythromycin [mart.] |
| AKOS015895249 |
| HY-B0220 |
| SCHEMBL2601 |
| erythromycin, antibiotic for culture media use only |
| E-3250 |
| AC-12901 |
| AB00051981_10 |
| AB00051981_09 |
| mfcd00084654 |
| SR-01000799155-2 |
| sr-01000799155 |
| erythromycin, united states pharmacopeia (usp) reference standard |
| erythromycin, tested according to ph.eur. |
| erythromycin, plant cell culture tested, ~98% |
| erythromycin a, european pharmacopoeia (ep) reference standard |
| erythromycin, for microbiological assay, european pharmacopoeia (ep) reference standard |
| SR-05000001618-2 |
| sr-05000001618 |
| SR-05000001618-1 |
| erythromycin, pharmaceutical secondary standard; certified reference material |
| SBI-0051368.P003 |
| HMS3712O04 |
| rkl10096 |
| erythromycin a, british pharmacopoeia (bp) reference standard |
| unii-8hph7nd0ln |
| Q213511 |
| BRD-K63550407-028-03-9 |
| BRD-K63550407-001-13-5 |
| [3r-(3r*,4s*,5s*,6r*,7r*,9r*,11r*,12r*,13s*,14r*)]-4-[(2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl]oxy]oxacyclotetrad |
| (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-(((2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyloxa |
| erythromycin 1000 microg/ml in acetonitrile |
| erythromycin (usp-rs) |
| api e.m. erythromycin |
| gallimycin injection, gallimycin-100 |
| gallimycin-36 |
| erythromycin base filmtab |
| erythromycinbase |
| erythromycin (usp monograph) |
| erythromycin (mart.) |
| erythromycinum (inn-latin) |
| spotex |
| erythromycin (usp:inn:ban:jan) |
| erythromycine (inn-french) |
| chebi:48923 |
| eritromicina (inn-spanish) |
| erythro-36, erythro-dry |
| api e.m erythromycin |
| erythromycinbase filmtab |
| erythromycin (ep monograph) |
| erythro-100 injection |
| Z2587996953 |
| enythromycin |
Erythromycin is a macrolide antibiotic that is also prescribed off-label in premature neonates as a prokinetic agent. It acts as a motilin receptor agonist in the upper gastrointestinal (GI) tract and increases gastric emptying.
Erythromycin (EM) has an anti-inflammatory effect that may account for its clinical benefit in the treatment of chronic inflammatory diseases such as diffuse panbronchiolitis. The drug has a motilin-like effect on the stomach and significantly increases the lower esophageal sphincter (LES) pressure in normal volunteers.
Erythromycin has an important place in treating acute upper and lower respiratory tract infections, acute otitis media, sinusitis, skin and soft tissue, osteomyelitis, prostatitis, infections due to Mycoplasma spp. It has been shown to interact with gastrointestinal smooth muscle in a similar manner to motilin, and has been postulated as a Motilin receptor agonist.
Erythromycin is known to produce long QTU intervals on the electrocardiogram (ECG) and to be associated with the development of torsade de pointes (TdP) It might inhibit the production of this mediator, restrict the neutrophil accumulation, modulate the excessive inflammation in the respiratory tract.
Erythromycin treatment significantly decreased cell proliferation and the expression of p-MEK1 and p-ERK1, and increased apoptosis in nasal polyp-derived cells compared with control cells. The treatment was well tolerated and mild adverse events caused no discontinuation during the study.
Erythromycin is associated with adverse reactions, including corrected QT interval prolongation and cytochrome P450 3A4 isoenzyme inhibition. Adverse events were reported in 12 of 45 and 6 of 40 of the patients treated with azithromycin and erythromyquin, respectively.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Human diploid fibroblasts cultured in Dulbecco's Modified Eagle's medium (DME) were exposed to different concentrations of 15 antibiotics to determine the limiting toxic concentration." | ( Toxicity of antibiotics on cultured human skin fibroblasts. Byarugaba, W; Koske-Westphal, T; Passarge, E; Rüdiger, HW; Wöhler, W, 1975) | 0.25 |
| " Clarithromycin also appears to be better tolerated than these agents, with a lower incidence of gastrointestinal adverse effects." | ( Clarithromycin: review of a new macrolide antibiotic with improved microbiologic spectrum and favorable pharmacokinetic and adverse effect profiles. Rapp, RP; Sturgill, MG, 1992) | 0.28 |
| " Eight patients (15%) in the clarithromycin group and 10 patients (20%) in the ampicillin group reported adverse events, the majority of which were mild or moderate in severity; six events in each treatment group were digestive-system disorders." | ( Comparative safety and efficacy of clarithromycin and ampicillin in the treatment of out-patients with acute bacterial exacerbation of chronic bronchitis. Craft, JC; Guay, DR, 1992) | 0.28 |
| " Twenty percent of these patients reported adverse events, and three-quarters of these were thought to be possibly or probably linked with the drug." | ( The tolerance and toxicity of clarithromycin. Wood, MJ, 1991) | 0.28 |
| " Adverse events were reported for 16% of patients in the clarithromycin group compared to 26% in the amoxycillin group." | ( The comparative efficacy and safety of clarithromycin and amoxycillin in the treatment of outpatients with acute maxillary sinusitis. Karma, P; Löth, S; Melén, I; Olén, L; Penttilä, M; Pukander, J; Savolainen, S; Ylikoski, J, 1991) | 0.28 |
| "7%) adverse events were reported." | ( Safety and efficacy of Clarithromycin in the treatment of acute mild to moderate respiratory tract infections. Bachand, RT; Coles, SJ; Millar, ED; O'Neill, SJ, 1991) | 0.28 |
| " Twelve patients prematurely discontinued the study (nine by the patient's request while feeling well; one because of cancer diagnosis; and two because of adverse events)." | ( The safety and efficacy of clarithromycin in patients with Legionella pneumonia. Ali, J; Bachand, R; Dawood, G; Hafeez, S; Hamedani, P; Quereshi, S; Raza, R; Yab, Z, 1991) | 0.28 |
| " Reversible hearing loss is an infrequently described adverse effect attributed to high-dose erythromycin therapy." | ( Erythromycin ototoxicity: a call to heighten recognition. Lapp, NL; Parker, JE; Whitener, CJ, 1991) | 1.94 |
| " The hypothesis that this toxic effect might have resulted from abnormal metabolism of cyclosporin by liver cytochrome P-450 IIIA was investigated with the [14C]erythromycin breath test, which is a measure of this enzyme's activity." | ( Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA. Aldrich, M; Campbell, DA; Kolars, JC; Lucey, MR; Merion, RM; Watkins, PB, 1990) | 0.48 |
| " Adverse events considered probably to relate to therapy were experienced by 2% of patients treated with clarithromycin and by 12." | ( Efficacy and safety of clarithromycin versus josamycin in the treatment of hospitalized patients with bacterial pneumonia. Scarpazza, G; Straneo, G, ) | 0.13 |
| " In this study, informing patients about side effects of therapy did not have any detectable adverse effects." | ( Does patient education cause side effects? A controlled trial. Baker, MG; Howland, JS; Poe, T, 1990) | 0.28 |
| " The introduction of oral erythromycin produces a two- to fourfold increase in the carbamazepine serum concentration and the resultant toxic manifestations." | ( Carbamazepine toxicity precipitated by intravenous erythromycin. Mitsch, RA, 1989) | 0.83 |
| " The enteric-coated tablet was associated with a higher incidence of individual adverse reactions; more patients discontinued it because of adverse GI effects." | ( Gastrointestinal side effects with erythromycin preparations. Carter, BL; Cole, KJ; Milavetz, G; Woodhead, JC, 1987) | 0.55 |
| " Therefore, blood level monitoring and careful regulation of CsA dose are necessary, in order to achieve the safe use of EES in transplant recipients." | ( Exacerbation of cyclosporine toxicity by concomitant administration of erythromycin. Cooley, DA; Flechner, SM; Frazier, OH; Jensen, CW; Kahan, BD; Lorber, MI; Van Buren, CT, 1987) | 0.51 |
| "Between 30 and 40 cases of reversible ototoxic side effects of erythromycin therapy have been reported previously but to our knowledge none with irreversible adverse reactions." | ( Irreversible ototoxic effect of erythromycin. Behrenth, E; Levin, G, 1986) | 0.79 |
| " EF was not cytotoxic after 18 h incubation at concentrations up to 8 X 10(-4) M and EE was much more toxic than EB at all concentrations studied." | ( Erythromycin toxicity in primary cultures of rat hepatocytes. Bégué, JM; Guillouzo, A; Villa, P, ) | 1.57 |
| " Chemical analysis of coir ash revealed the presence of toxic chemical constituents in appreciable amounts." | ( Coir fibre toxicity: in vivo and in vitro studies. Bhattacherjee, JW; Dogra, RK; Saxena, RP, 1982) | 0.26 |
| " Serum carbamazepine levels were measured before, during, and, in most cases, after the toxic episodes." | ( Carbamazepine--erythromycin interaction leading to carbamazepine toxicity in four epileptic children. Cate, JC; Hedrick, R; Lamb, WA; Morin, R; Williams, F, 1983) | 0.62 |
| " These include safe and effective concentrations of 30 or 60 mg/l Gentamicin, Sisomicin or Tobramycin and their application by ointment." | ( [Topically induced ototoxicity]. Federspil, P, 1984) | 0.27 |
| "Based on the main physiological and ultrastructural effects induced in Euglena gracilis by erythromycin, one of the least toxic of the commonly used antibiotics that specifically inhibit protein synthesis on 70S ribosomes of prokaryotic organisms, a symptomatologic picture is outlined which could be useful for the preliminary evaluation of the toxicity of antibacterial agents." | ( Effects of erythromycin on Euglena gracilis as a model for testing the toxicity of antibacterial drugs. Bassi, M; Dall'Olio, G; Fasulo, MP, 1981) | 0.87 |
| " This study indicates that use of half dose of DTaP in adults appears safe and should be considered as an adjunct to chemoprophylaxis during institutional outbreaks." | ( Use and safety of acellular pertussis vaccine among adult hospital staff during an outbreak of pertussis. Baron, R; Dales, L; Jackson, R; Nelson, M; Shefer, A; Werner, B, 1995) | 0.29 |
| "This epidemiologic study surveyed pet owners for observations of adverse reactions to oral antibacterials which were prescribed to outpatients at a university teaching hospital." | ( Adverse side effects of oral antibacterial therapy in dogs and cats: an epidemiologic study of pet owners' observations. Keisling, K; Kunkle, GA; Sundlof, S, ) | 0.13 |
| " There were no significant differences in the incidence or severity of drug-related adverse events, which, when reported, were mild and transient." | ( Comparative efficacy and safety of cefprozil versus penicillin, cefaclor and erythromycin in the treatment of streptococcal pharyngitis and tonsillitis. McCarty, JM, 1994) | 0.52 |
| " Of the 1222 patients included, no significant differences in the number of patients reporting adverse events were observed." | ( A multicentre study comparing the safety and efficacy of dirithromycin with erythromycin in the treatment of bronchitis. Gaillat, J, 1993) | 0.52 |
| " The incidence and nature of adverse events were similar in elderly and non-elderly subjects, and there was no electrocardiographic evidence that dirithromycin caused an increased incidence of cardiac disturbances." | ( Pharmacokinetics and safety of dirithromycin in the elderly. Varanese, L, 1993) | 0.29 |
| " The most frequently reported adverse events for both dirithromycin and comparator treatment groups were gastrointestinal in nature." | ( Safety profile of dirithromycin. Conforti, PM; Sides, GD, 1993) | 0.29 |
| "Ototoxicity is probably the least acknowledged adverse reaction of erythromycin." | ( Ototoxicity of erythromycin in man: electrophysiologic approach. Angeles De Cos, M; De Pablos, C; Pascual, J; Sacristán, JA; Soto, J; Tasis, A; Valle, R; Zurbano, F, 1993) | 0.88 |
| " These cells were exposed to antibiotics for 24 hr and subsequently toxic effects on cells were evaluated by three different assays." | ( Cytotoxic effects of four antibiotics on endothelial cells. Lanbeck, P; Paulsen, O, 1995) | 0.29 |
| " Erythromycin estolate was the most toxic macrolide in all tests differing clearly from all the other macrolides studied." | ( Cytotoxicity of macrolide antibiotics in a cultured human liver cell line. Tuominen, RK; Vainio, PJ; Viluksela, M, 1996) | 1.2 |
| " Adverse events were reported in 12 of 45 and 6 of 40 of the patients treated with azithromycin and erythromycin, respectively, a difference which was not statistically significant." | ( Prospective open randomized study comparing efficacies and safeties of a 3-day course of azithromycin and a 10-day course of erythromycin in children with community-acquired acute lower respiratory tract infections. Gossens, MM; Kimpen, JL; Roord, JJ; Wolf, BH, 1996) | 0.72 |
| " Patients from 23 geographically diverse sites were evaluated for clinical outcomes and/or adverse events at Days 3 to 5, Days 15 to 19 and 4 to 6 weeks posttherapy." | ( Safety and efficacy of azithromycin in the treatment of community-acquired pneumonia in children. Campbell, M; Cassell, GH; Hammerschlag, MR; Harris, JA; Kolokathis, A, 1998) | 0.3 |
| " Treatment-related adverse events occurred in 11." | ( Safety and efficacy of azithromycin in the treatment of community-acquired pneumonia in children. Campbell, M; Cassell, GH; Hammerschlag, MR; Harris, JA; Kolokathis, A, 1998) | 0.3 |
| " The system's impact on the use of dangerous drug combinations and related adverse events was evaluated by a retrospective analysis of patients receiving cisapride with contraindicated medications in the 2 years before and after implementation." | ( Impact of a Web-based clinical information system on cisapride drug interactions and patient safety. Bailey, TC; Frisse, ME; McMullin, ST; Reichley, RM; Steib, SA; Watson, LA, 1999) | 0.3 |
| "7%) during the control period experienced serious adverse events that may have been related to the targeted drug interactions." | ( Impact of a Web-based clinical information system on cisapride drug interactions and patient safety. Bailey, TC; Frisse, ME; McMullin, ST; Reichley, RM; Steib, SA; Watson, LA, 1999) | 0.3 |
| "An automated system running as a safety net can be an efficient method of detecting contraindicated drug combinations and serves an important role in the avoidance of potentially serious adverse drug events." | ( Impact of a Web-based clinical information system on cisapride drug interactions and patient safety. Bailey, TC; Frisse, ME; McMullin, ST; Reichley, RM; Steib, SA; Watson, LA, 1999) | 0.3 |
| " Safety parameters were local tolerance and adverse events." | ( Clinical efficacy and safety of a topical combination of retinaldehyde 0.1% with erythromycin 4% in acne vulgaris. Beylot, C; Bonérandi, JJ; Dréno, B; Dupuy, P; Lehucher-Ceyrac, D; Morel, P; Slimani, S; Vienne, MP, 1999) | 0.53 |
| "To determine whether foals with pneumonia that were treated with erythromycin, alone or in combination with rifampin or gentamicin, had a higher risk of developing adverse effects, compared with foals treated with trimethoprim-sulfamethoxazole (TMS), penicillin G procaine (PGP), or a combination of TMS and PGP (control foals)." | ( Risk of adverse effects in pneumonic foals treated with erythromycin versus other antibiotics: 143 cases (1986-1996). Gardner, IA; Stratton-Phelps, M; Wilson, WD, 2000) | 0.79 |
| " Relative risk (RR) and attributable risk (AR) were calculated to compare risk of adverse reactions between foals treated with erythromycin and control foals." | ( Risk of adverse effects in pneumonic foals treated with erythromycin versus other antibiotics: 143 cases (1986-1996). Gardner, IA; Stratton-Phelps, M; Wilson, WD, 2000) | 0.76 |
| "3%) adverse event with all three therapies." | ( The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product. Hickman, JG; Jarratt, MT; Levy, SF; Leyden, JJ; Stewart, DM, ) | 0.33 |
| "Although potentially significant adverse reactions and drug interactions have been reported in association with erythromycin, oral tetracyclines, and trimethoprim-sulfamethoxazole, overall these agents are associated with excellent safety profiles, especially considering their widespread use over many years." | ( Systemic therapy for rosacea: focus on oral antibiotic therapy and safety. Del Rosso, JQ, 2000) | 0.52 |
| " Clarithromycin, a newer macrolide, has good in vitro activity against Bordetella pertussis and a better side effect profile." | ( Efficacy and safety of clarithromycin versus erythromycin for the treatment of pertussis: a prospective, randomized, single blind trial. Lebel, MH; Mehra, S, 2001) | 0.57 |
| " Adverse event data were collected throughout the study." | ( Efficacy and safety of clarithromycin versus erythromycin for the treatment of pertussis: a prospective, randomized, single blind trial. Lebel, MH; Mehra, S, 2001) | 0.57 |
| " The clarithromycin group had significantly fewer adverse events [45% (34 of 76) for clarithromycin vs." | ( Efficacy and safety of clarithromycin versus erythromycin for the treatment of pertussis: a prospective, randomized, single blind trial. Lebel, MH; Mehra, S, 2001) | 0.57 |
| " The 14C-ERMBT is safe and complies with the European regulations regarding the administration of 14C-labelled compounds in humans." | ( The [14C-N-methyl]-erythromycin breath test dosimetry complies with the French regulations for radiation safety. Bailliart, O; Bergmann, JF; Duet, M; Knellwolf, AL; Mouly, S; Nataf, V; Rizzo-Padoin, N; Salvat, C; Simoneau, G, 2003) | 0.65 |
| "Although it is well known that a variety of antibacterials may incidentally cause malignant arrhythmia, the list of drugs causing arrhythmia and the impact of these adverse effects are still uncertain." | ( Generating signals of drug-adverse effects from prescription databases and application to the risk of arrhythmia associated with antibacterials. Bagnardi, V; Botteri, E; Carobbio, A; Corrao, G; Falcone, C; Leoni, O; Zambon, A, 2005) | 0.33 |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | ( Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) | 0.32 |
| " Oral daily administration of toxic dose of erythromycin stearate (EE, 100 mg/kg body weight) was given to male rats for fourteen days to induce hepatotoxicity." | ( Protective role of dimethyl diphenyl bicarboxylate (DDB) against erythromycin induced hepatotoxicity in male rats. Abdel-Hameid, NA, 2007) | 0.84 |
| "This study suggests that erythromycin is effective and safe as a sclerosing agent for pleurodesis in patients with recurrent malignant pleural effusions." | ( Efficacy and safety of erythromycin as sclerosing agent in patients with recurrent malignant pleural effusion. Bagalas, V; Balassoulis, G; Chloros, D; Kontakiotis, T; Manika, K; Patakas, D; Porpodis, K; Sichletidis, L; Spyratos, D; Zarogoulidis, K, 2008) | 0.96 |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | ( Developing structure-activity relationships for the prediction of hepatotoxicity. Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) | 0.36 |
| " The cyanobacterium was more sensitive than the green alga to the toxic effect of antibiotics." | ( Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment. Boltes, K; Fernández-Piñas, F; González-Pleiter, M; Gonzalo, S; Leganés, F; Marco, E; Rodea-Palomares, I; Rosal, R, 2013) | 0.39 |
| " No serious adverse events occurred and no persistent adverse events were reported at the end of study." | ( An open-label study to estimate the effect of steady-state erythromycin on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban in subjects with renal impairment and normal renal function. Ariyawansa, J; Haskell, L; Moore, KT; Natarajan, J; Turner, KC; Vaidyanathan, S, 2014) | 0.65 |
| " We collected laboratory and clinical information while infants were exposed to erythromycin or metoclopramide and described the frequency of laboratory abnormalities and clinical adverse events (AEs)." | ( Use and Safety of Erythromycin and Metoclopramide in Hospitalized Infants. Arnold, C; Benjamin, DK; Cheeseman, J; Cho, J; Chu, V; Clark, RH; Ericson, JE; Hornik, CP; Kaneko, S; Smith, PB; Wilson, E, 2015) | 0.98 |
| " Macrolides, mainly erythromycin and clarithromycin, rarely show QT prolongation, as their infamous adverse reaction which can lead to torsades de pointes." | ( Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. Eybagi, S; Kazerouni, NP; Naserzadeh, P; Pourahmad, J; Salimi, A; Seydi, E, 2016) | 0.76 |
| " The present study aimed to assess the toxic effects of ERY in Oncorhynchus mykiss after acute and chronic exposures." | ( Acute and chronic effects of erythromycin exposure on oxidative stress and genotoxicity parameters of Oncorhynchus mykiss. Antunes, SC; Correia, AT; Nunes, B; Rodrigues, S, 2016) | 0.73 |
| "The degradation of veterinary drugs approved for use in aquaculture is very important in the evaluation of the impact of these drugs on the environment and to ensure safe food production." | ( Environmental impact assessment of veterinary drug on fish aquaculture for food safety. Kwon, JW, 2016) | 0.43 |
| " The here-obtained data suggest that the observed alterations in terms of detoxification enzymes may have prevented the establishment of a set of toxic responses, namely, neurotoxic and metabolic disorders." | ( Toxicity of erythromycin to Oncorhynchus mykiss at different biochemical levels: detoxification metabolism, energetic balance, and neurological impairment. Antunes, SC; Correia, AT; Nunes, B; Rodrigues, S, 2019) | 0.89 |
| " Erythromycin is associated with adverse reactions, including corrected QT interval prolongation and cytochrome P450 3A4 isoenzyme inhibition." | ( Safe Use of Erythromycin For Refractory Gastroparesis After Small Bowel Transplantation. Cruz, RJ; Humar, A; Poloyac, K; Roberts, M; Stein, W, 2022) | 2.01 |
| " TPs may be more toxic than the parent compounds, but their structures, yields and ecotoxicity remain to be ascertained in most cases." | ( Transformation of macrolide antibiotics during chlorination process: Kinetics, degradation products, and comprehensive toxicity evaluation. Han, J; Korshin, GV; Li, J; Li, W; Liu, K; Min, Z; Zhang, M, 2023) | 0.91 |
The effect of erythromycin on the pharmacokinetic disposition of oral sertindole, a new antipsychotic compound, was investigated. The effects of the macrolide antibiotics, erythyromycin, clarithromycin and roxithr were also investigated.
| Excerpt | Reference | Relevance |
|---|---|---|
| " It is particularly difficult to evaluate possible alterations in pharmacokinetic parameters that may be due to pregnancy." | ( Pharmacokinetics of antibiotics in pregnancy and labour. Philipson, A, ) | 0.13 |
| " The biological half-life of erythromycin in serum was 2 hr in individuals with normal renal function." | ( Pharmacokinetics of intravenous erythromycin. Craig, WA; Welling, PG, 1978) | 0.83 |
| "Serum erythromycin concentration data from several repetitive dosing studies were analyzed with newly developed computer methods for fitting multiple-dose data and generating nonlinear least-squares estimates of pharmacokinetic parameters." | ( Pharmacokinetics of erythromycin on repetitive dosing. Colburn, WA; Di Santo, AR; Gibaldi, M, 1977) | 1.06 |
| " The half-life (mean+/-SD) of erythromycin was 3-16 h+/-0-44, while that of tylosin was 1-62 h+/-0-17." | ( Pharmacokinetic interpretation of erythromycin and tylosin activity in serum after intravenous administration of a single dose to cows. Baggot, JD; Gingerich, DA, 1976) | 0.82 |
| " Drug elimination is biphasic, with a terminal half-life of up to 5 days." | ( Azithromycin--spectrum of activity, pharmacokinetics, and clinical applications. Drew, RH; Gallis, HA, 1992) | 0.28 |
| " Clarithromycin has a superior pharmacokinetic profile to that of erythromycin, allowing the benefits of twice daily administration with the potential for increased compliance among outpatients where a more frequent regimen for erythromycin might otherwise be indicated." | ( Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Clissold, SP; Peters, DH, 1992) | 0.52 |
| " Differences in the pharmacokinetic parameters after administration of equivalent doses of the salts, indicate possible variation in efficacies of different salts." | ( Studies on the intravenous pharmacokinetics in rabbit and in vitro protein binding of two new salts of erythromycin: erythromycin maltobionate and erythromycin fumarate. Basu, SK; Goswami, BB; Manna, PK, 1992) | 0.5 |
| " Roxithromycin showed a prolonged elimination half-life compared with clarithromycin and its 14-OH metabolite." | ( Macrolide pharmacokinetics and dose scheduling of roxithromycin. Aamo, T; Nilsen, OG; Svarva, P; Zahlsen, K, ) | 0.13 |
| " Based on the pharmacokinetic profiles, it is suggested that 1,200,000 IU benzathine penicillin G given every 4 weeks is an appropriate regimen for preventing the recurrence of rheumatic fever in Thai adults." | ( Pharmacokinetics of rheumatic fever prophylaxis regimens. Kobwanthanakun, S; Lertluknithi, R; Pruksachatvuthi, S; Thamlikitkul, V, 1992) | 0.28 |
| " Azithromycin's serum levels decline in a polyphasic manner with a terminal half-life of approximately 60 hours." | ( Tissue-directed pharmacokinetics. Ballow, CH; Schentag, JJ, 1991) | 0.28 |
| "Azithromycin, a macrolide antibiotic with an enhanced antimicrobial spectrum, was found to have a longer half-life than erythromycin, with marked tissue penetration." | ( Pharmacokinetics of azithromycin after single oral dosing of experimental animals. Davila, D; Kolacny-Babić, L; Plavsić, F, 1991) | 0.49 |
| "The usefulness of erythromycin is limited by its poor pharmacokinetic profile which is characterised by low blood levels and poor gastric acid stability." | ( The pharmacokinetics of azithromycin and their clinical significance. Lode, H, 1991) | 0.62 |
| " Pharmacokinetic results indicated that Cmax, Cmin and urinary excretion were similar in the two age groups." | ( An open study to compare the pharmacokinetics, safety and tolerability of a multiple-dose regimen of azithromycin in young and elderly volunteers. Antrobus, JH; Coates, P; Daniel, R; Houston, AC; Taylor, T, 1991) | 0.28 |
| " Pharmacokinetic studies on the preparation were conducted." | ( [Pharmacokinetics of protegentin, a combined preparation]. Firsov, AA; Gagaeva, EV, 1991) | 0.28 |
| "A method is described to predict the efficacy of antibiotics at changing concentrations in vitro or in an experimental thigh infection in granulocytopenic mice from the activity at constant concentrations in vitro, using pharmacokinetic parameters." | ( A predictive parameter of antibacterial efficacy in vivo, based on efficacy in vitro and pharmacokinetics. Mattie, H, 1990) | 0.28 |
| "The steady-state plasma concentrations and pharmacokinetic characteristics of theophylline were studied during intermittent treatment with dirithromycin." | ( Changes in the steady-state pharmacokinetics of theophylline during treatment with dirithromycin. Bachmann, K; DeSante, K; Jauregui, L; Martin, M; Nunlee, M; Sides, GD; Sullivan, T, 1990) | 0.28 |
| " The mean elimination half-life was significantly longer in the elderly group only after multiple dosing (4." | ( Effect of age on single- and multiple-dose pharmacokinetics of erythromycin. Miglioli, PA; Okolicsanyi, L; Orlando, R; Palatini, P; Pivetta, P; Strazzabosco, M, 1990) | 0.52 |
| " There were no significant alterations of bromocriptine pharmacokinetic parameters after caffeine, although statistical power was very low." | ( Pharmacokinetic evaluation of erythromycin and caffeine administered with bromocriptine. Berchou, RC; Kareti, D; LeWitt, PA; Nelson, MV, 1990) | 0.57 |
| " Pharmacokinetic investigation We studied serum concentrations and urinary excretions after single oral administration of TE-031 granules and tablets." | ( [Pharmacokinetic and clinical studies of clarithromycin in the pediatric field]. Imamura, H; Nakayama, N; Tsuji, Y; Yanagi, T; Yanagishima, M; Yanai, M, 1989) | 0.28 |
| " These results indicate that clarithromycin has pharmacokinetic properties superior to those of erythromycin." | ( Comparative pharmacokinetics of clarithromycin (TE-031), a new macrolide antibiotic, and erythromycin in rats. Kohno, Y; Suga, T; Suwa, T; Yoshida, H, 1989) | 0.72 |
| " Numerous pharmacokinetic drug interactions of potential clinical significance exist because other drugs may induce or inhibit the metabolism of CyA." | ( Cyclosporine pharmacokinetic drug interactions. Baciewicz, AM; Baciewicz, FA, 1989) | 0.28 |
| " From the results it is concluded that perioperative antibiotic therapy with erythromycin has pharmacodynamic advantages." | ( [Pharmacodynamics of erythromycin lactobionate during tonsillectomy in children]. Leuthardt, R; Morger, R; Trümpi, B, 1989) | 0.82 |
| " This compound exhibited a uniformly long elimination half-life and was distributed exceptionally well into all tissues." | ( Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Cimochowski, CR; English, AR; Faiella, JA; Girard, AE; Girard, D; Gootz, TD; Haskell, SL; Retsema, JA, 1987) | 0.27 |
| " With use of numerous multiple-dosing regimens in an animal model, this study is the first to successfully minimize the interdependence between pharmacokinetic parameters and thereby determine, by stepwise multivariate regression analysis, that the time that serum levels exceeded the minimum inhibitory concentration (MIC) was the most significant parameter determining efficacy for beta-lactams and erythromycin against various pathogens, whereas the log area under the curve was the major parameter for aminoglycosides." | ( Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. Craig, WA; Ebert, S; Gudmundsson, S; Leggett, J; Turnidge, J; Vogelman, B, 1988) | 0.44 |
| "05) with respect to the area under the plasma phenytoin concentration-time curve, the fraction of phenytoin unbound in plasma, the area under the unbound phenytoin concentration-time curve, the elimination half-life of phenytoin or the fraction of the dose excreted in urine as free and conjugated hydroxyphenylphenylhydantoin." | ( Lack of effect of erythromycin on the pharmacokinetics of single oral doses of phenytoin. Coulthard, K; Milne, RW; Nation, RL; Penna, AC; Roberts, G; Sansom, LN, 1988) | 0.61 |
| " The results of the pharmacokinetic study suggest that accumulation of the drug during repetitive multiple doses is predictable." | ( Pharmacokinetics and human tissue penetration of flurithromycin. Benoni, G; Bertrand, C; Consolo, U; Cuzzolin, L; Ferronato, G; Fracasso, ME; Leone, R; Puchetti, V, 1988) | 0.27 |
| " The lower percentage of hydrolysis of erythromycin estolate (41 versus 69%) combined with its longer half-life (5." | ( Pharmacokinetic advantages of erythromycin estolate over ethylsuccinate as determined by high-pressure liquid chromatography. Bergeron, MG; Croteau, D; LeBel, M, 1988) | 0.83 |
| "The search for erythromycin derivatives with improved antibacterial and/or pharmacokinetic properties, has led to the synthesis of several new agents." | ( Comparative pharmacokinetics of macrolides. Nilsen, OG, 1987) | 0.63 |
| " Total clearance, terminal half-life and volume of distribution of erythromycin were not altered by concomitant theophylline treatment." | ( Influence of theophylline on the renal clearance of erythromycin. Gundert-Remy, U; Hildebrandt, R; Möller, H, 1987) | 0.76 |
| " These pharmacokinetic changes are suggestive of an enhanced bioavailability of erythromycin in chronic renal failure which might predispose uremics to the ototoxicity of the drug." | ( Changes in erythromycin pharmacokinetics induced by renal failure. Fredj, G; Kanfer, A; Kenouch, S; Méry, JP; Stamatakis, G; Torlotin, JC, 1987) | 0.89 |
| " It is concluded that in cirrhotic patients, low serum AAG levels and reduced liver metabolic capacity may lead to marked changes in pharmacokinetics of erythromycin, and that similar results might be expected for drugs which exhibit the same serum binding and pharmacokinetic behaviour as erythromycin." | ( Pharmacokinetics of erythromycin in patients with severe cirrhosis. Respective influence of decreased serum binding and impaired liver metabolic capacity. Barre, J; Deforges, L; Dhumeaux, D; Houin, G; Mallat, A; Rosenbaum, J; Tillement, JP, 1987) | 0.79 |
| "The pharmacokinetic properties of cyclosporine and mainly its absorption and hepatic elimination can vary in each patient in relation to the subject's individual characteristics (inter-subject variability), as well as in an individual patient during his treatment because of clinical episodes or drug interactions (intra-subject variabilities)." | ( [Pharmacokinetics and metabolism of cyclosporin; drug interactions]. Kiechel, JR; Lavene, D; Le Bigot, JF, 1987) | 0.27 |
| " Warfarin is a drug with pharmacokinetic characteristics enabling it to be used in a single dose single sample procedure in screening for host factor influences on its clearance." | ( Screening for the influence of host factors on warfarin clearance using a single dose single sample procedure. Bachmann, K, 1986) | 0.27 |
| " At 1 week before (1 dose) and at 48, 60, and 72 hours (3 doses) after Pasteurella administration, the calves were given erythromycin at a dosage of 15 mg/kg, and the pharmacokinetic values were determined." | ( Effects of experimentally induced Pasteurella haemolytica pneumonia on the pharmacokinetics of erythromycin in the calf. Burrows, GE, 1985) | 0.7 |
| " When the pharmacokinetic data was fitted to an allometric model, the logarithms of volume of distribution, clearance, and half-life were linearly related to the logarithms of body weight." | ( Interspecies correlation of the pharmacokinetics of erythromycin, oleandomycin, and tylosin. Duthu, GS, 1985) | 0.52 |
| " We found no evidence of a pharmacokinetic interaction between theophylline and erythromycin at steady state." | ( The effect of erythromycin on theophylline pharmacokinetics at steady state. Bauman, JL; Hasegawa, GR; Leeds, NH; Maddux, MS; Organek, HW, 1982) | 0.85 |
| " The pharmacokinetic results indicate that both dosage alternatives are suitable and result in similar steady-state peak levels, but the initial dose should be 500 mg." | ( Pharmacokinetics of a new, microencapsulated erythromycin base after repeated oral doses. Bergan, T; Josefsson, K; Magni, L; Midtvedt, T; Steinbakk, M, 1982) | 0.52 |
| "The objective of this study was to compare the pharmacokinetic behavior of erythromycin in normal volunteers with that in subjects with alcoholic liver disease." | ( Pharmacokinetics of erythromycin in normal and alcoholic liver disease subjects. Bates, TR; DiSanto, AR; Gibaldi, M; Hall, KW; Nelson, E; Nightingale, CH, 1982) | 0.82 |
| " Compared with erythromycin, dirithromycin has a long elimination half-life enabling once-daily administration, and it also achieves a greater cellular:extracellular concentration ratio and higher concentration in some tissues." | ( Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Brogden, RN; Peters, DH, 1994) | 0.64 |
| " The primary pharmacodynamic end point of the study was the difference between baseline and day 10 mean QTc intervals obtained from surface electrocardiograms." | ( Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations. Affrime, MB; Brannan, MD; Cayen, MN; Lin, CC; Radwanski, E; Reidenberg, P; Shneyer, L, 1995) | 0.55 |
| "Erythromycin (EM) pharmacokinetic variables were studied after IV administration of the drug (10 mg/kg of body weight) to 1-, 6-, and 15-day-old pigs." | ( Impact of age-related alteration of plasma alpha 1-acid glycoprotein concentration on erythromycin pharmacokinetics in pigs. Kinoshita, T; Kokue, E; Shimoda, M; Son, DS, 1995) | 1.96 |
| " Drugs characterized by low accumulation indices (AI) showed virtually no change in the 90% confidence interval (CI) of AUC and CMAX upon multiple dosing." | ( Comparison of single and multiple dose pharmacokinetics using clinical bioequivalence data and Monte Carlo simulations. el-Tahtawy, AA; Jackson, AJ; Ludden, TM, 1994) | 0.29 |
| " Cmax and AUC were consistently lower in subjects with parenchymal disease than those with biliary disease or normal volunteers but the reason for this is unclear." | ( Pharmacokinetics of dirithromycin in patients with impaired hepatic function. Cerimele, B; DeSante, K; Gereats, D; Janda, R; Johlin, F; LaBreque, D; Lanier, T; Shreves, T; Sides, G, 1993) | 0.29 |
| "The pharmacokinetic properties of four erythromycin formulations were compared in six adult horses after administration of single and multiple oral doses." | ( Comparison of oral erythromycin formulations in the horse using pharmacokinetic profiles. Burrows, G; Clarke, C; Ewing, PJ; MacAllister, C, 1994) | 0.89 |
| "Steady-state theophylline pharmacokinetic parameters were studied in a panel of 14 patients with chronic obstructive pulmonary disease (COPD)." | ( Steady-state pharmacokinetics of theophylline in COPD patients treated with dirithromycin. Bachmann, K; Jauregui, L; Sides, G; Sullivan, TJ, 1993) | 0.29 |
| " The elimination half-life was 53." | ( Pharmacokinetics of azithromycin in patients with impaired hepatic function. Carlà, V; Crispo, A; Fallani, S; Mazzei, T; Novelli, A; Periti, P; Surrenti, C; Surrenti, E, 1993) | 0.29 |
| " There was also a trend for values for the area under the plasma concentration versus time curve to increase with age, but neither of these pharmacokinetic parameters was significantly altered with age." | ( Pharmacokinetics and safety of dirithromycin in the elderly. Varanese, L, 1993) | 0.29 |
| " Dirithromycin is characterized by a plasma elimination half-life of 44 h (range 16-65 h) that permits once-daily administration." | ( Pharmacokinetics of dirithromycin. Black, HR; Busch, U; Cerimele, BJ; DeSante, KA; Sides, GD, 1993) | 0.29 |
| "The pharmacokinetic and pharmacodynamic interaction between azithromycin (CAS 83905-01-5), an azalide antibiotic, and midazolam (CAS 59467-70-8), a short-acting hypnotic agent, was investigated in an open, three-way cross-over study, including erythromycin (CAS 114-07-8) as a positive control." | ( Influence of the antibiotics erythromycin and azithromycin on the pharmacokinetics and pharmacodynamics of midazolam. Laufen, H; Leitold, M; Scharpf, F; Wildfeuer, A; Yeates, RA; Zimmermann, T, 1996) | 0.77 |
| "The effects of the macrolide antibiotics, erythromycin, clarithromycin and roxithromycin, on the pharmacokinetic profile of phenytoin were studied in rats." | ( Pharmacokinetic interactions between erythromycin, clarithromycin, roxithromycin and phenytoin in the rat. al-Humayyd, MS, ) | 0.67 |
| "In the escalating-dose group, delavirdine displayed nonlinear kinetics as indicated by the decreasing oral clearance, maximum steady-state plasma concentration/minimum steady-state plasma concentration ratio, and log-linear terminal rate constant, as well as by increasing half-life at higher doses; the ratio of desisopropyl-delavirdine formation clearance to elimination clearance was also reduced." | ( Steady-state pharmacokinetics of delavirdine in HIV-positive patients: effect on erythromycin breath test. Amidon, GL; Blake, DS; Carver, PL; Cheng, CL; Cox, SR; Kauffman, CA; Meyer, KM; Smith, DE; Stetson, PL; Watkins, PB, 1997) | 0.52 |
| " aureus 1199), in an in vitro pharmacodynamic infection model." | ( Pharmacodynamics of RP 59500 (quinupristin-dalfopristin) administered by intermittent versus continuous infusion against Staphylococcus aureus-infected fibrin-platelet clots in an in vitro infection model. Houlihan, HH; Kaatz, GW; Mercier, RC; Rybak, MJ, 1997) | 0.3 |
| " Pharmacokinetic interactions with other drugs have been described but, in some cases, their mechanism is unknown." | ( Pharmacokinetic interactions involving clozapine. Taylor, D, 1997) | 0.3 |
| "Published trials and case reports relevant to the human metabolism of clozapine and to suspected pharmacokinetic interactions were reviewed." | ( Pharmacokinetic interactions involving clozapine. Taylor, D, 1997) | 0.3 |
| " (2) In phase I-II human studies, classic pharmacokinetic measurements can be coupled with imaging measurements (a) to define optimal dosing schedule; (b) to define the potential utility of interventions in particular clinical situations; and (c) to formulate the design of phase III studies that are crucial for drug licensure." | ( The role of positron emission tomography in pharmacokinetic analysis. Alpert, NM; Babich, JW; Fischman, AJ; Rubin, RH, 1997) | 0.3 |
| "This report includes a recalculation of the pooled data of 2 pharmacokinetic and pharmacodynamic studies of the interaction between the hypnotic midazolam and the antibiotics erythromycin, clarithromycin (macrolides), and azithromycin (an azalide)." | ( Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics, erythromycin, clarithromycin, and the azalide azithromycin. Laufen, H; Schumacher, T; Yeates, RA; Zimmermann, T, 1997) | 0.71 |
| "The effect of erythromycin on the pharmacokinetic disposition of oral sertindole, a new antipsychotic compound, was investigated." | ( The effect of erythromycin on the CYP3A component of sertindole clearance in healthy volunteers. Cao, G; Granneman, GR; Mack, RJ; Wong, SL, 1997) | 1.02 |
| "In this study, we determined the efficacy of various dosing regimens for erythromycin and azithromycin against four pneumococci with different susceptibilities to penicillin in an in vitro pharmacokinetic model and in a mouse peritonitis model." | ( Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo. den Hollander, JG; Espersen, F; Frimodt-Møller, N; Fuursted, K; Knudsen, JD; Mouton, JW; Verbrugh, HA, 1998) | 0.78 |
| " had a modest influence on cerivastatin clearance, leading to a mean increase in the maximum plasma concentration (Cmax) of 13% and a slightly increased terminal half-life (approximately 10%), resulting in a mean elevation of the area under the curve (AUC) of 21%; time to peak (tmax) remained unchanged." | ( Influence of erythromycin pre- and co-treatment on single-dose pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin. Kuhlmann, J; Mück, W; Ochmann, K; Rohde, G; Unger, S, 1998) | 0.67 |
| " In addition, the small increase in cerivastatin half-life does not predict an accumulation beyond steady state." | ( Influence of erythromycin pre- and co-treatment on single-dose pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin. Kuhlmann, J; Mück, W; Ochmann, K; Rohde, G; Unger, S, 1998) | 0.67 |
| "The absorption kinetics of the erythromycin suspension was notable for short lag times and early tmax, while lag times and tmax were delayed with the tablet form." | ( Which form of erythromycin should be used to treat gastroparesis? A pharmacokinetic analysis. Ehrenpreis, ED; Nellans, H; Zaitman, D, 1998) | 0.95 |
| " The actual interactions, and their pharmacodynamic consequences, were verified in a controlled clinical study." | ( Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences. Counihan, M; Duan, SX; Durol, AL; Graf, JA; Greenblatt, DJ; Harmatz, JS; Mertzanis, P; Shader, RI; von Moltke, LL; Wright, CE, 1998) | 0.3 |
| "32 ng/mL) and elimination half-life (2." | ( Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences. Counihan, M; Duan, SX; Durol, AL; Graf, JA; Greenblatt, DJ; Harmatz, JS; Mertzanis, P; Shader, RI; von Moltke, LL; Wright, CE, 1998) | 0.3 |
| " Anticipated interactions, and their pharmacodynamic consequences in volunteer subjects, were verified in vivo." | ( Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences. Counihan, M; Duan, SX; Durol, AL; Graf, JA; Greenblatt, DJ; Harmatz, JS; Mertzanis, P; Shader, RI; von Moltke, LL; Wright, CE, 1998) | 0.3 |
| " No statistically significant differences in maximum plasma concentration (Cmax), area under the concentration-time curve (AUC tau), or half-life (t1/2) of tiagabine were observed when tiagabine was administered alone or in combination with erythromycin." | ( Lack of pharmacokinetic interaction between tiagabine and erythromycin. Agersø, H; Groes, L; Kruse, T; Thomsen, MS, 1998) | 0.73 |
| " In conclusion, it was shown that a pharmacodynamic interaction contributes to the electrocardiographic adverse reaction (i." | ( Pharmacodynamic analysis of the electrocardiographic interaction between disopyramide and erythromycin in rats. Hanada, E; Iga, T; Kotaki, H; Ohtani, H; Sato, H; Sawada, Y, 1999) | 0.52 |
| " The mean terminal half-life was approximately 45 and 44 hours, respectively." | ( Lack of effect of erythromycin and ketoconazole on the pharmacokinetics and pharmacodynamics of steady-state intranasal levocabastine. Grover, M; Hall, N; Hassell, A; Hunt, T; Lee, P; Mechlinski, W; Pesco-Koplowitz, L; Smith, R; Travers, S; Wiesinger, B; Zhou, H, 1999) | 0.64 |
| "In the last decade three important pharmacodynamic parameters: T>MIC, Cmax/MIC and AUC/MIC, have been shown to correlate well with in-vitro antimicrobial efficacy and that found in animal models, differentiating among groups of antibiotics with diverse mechanisms of action such as exposure time or concentration-dependent effect." | ( Clarithromycin: pharmacokinetic and pharmacodynamic interrelationships and dosage regimen. Mazzei, T; Periti, P, 1999) | 0.3 |
| " Venous blood samples were obtained at specific times after drug administration, and plasma was harvested for determination of erythromycin concentrations by microbiologic assay and a HPLC method Pharmacokinetic analysis of plasma concentration-time data was performed, and results derived from each method were compared." | ( Comparison of microbiologic and high-performance liquid chromatography assays to determine plasma concentrations, pharmacokinetics, and bioavailability of erythromycin base in plasma of foals after intravenous or intragastric administration. Lakritz, J; Mihalyi, JE; Wilson, WD, 1999) | 0.71 |
| " Comparing pharmacokinetic data obtained by the 2 methods revealed substantial differences in results." | ( Comparison of microbiologic and high-performance liquid chromatography assays to determine plasma concentrations, pharmacokinetics, and bioavailability of erythromycin base in plasma of foals after intravenous or intragastric administration. Lakritz, J; Mihalyi, JE; Wilson, WD, 1999) | 0.5 |
| " Mean values for argatroban area under the concentration-time curves (AUC0-inf), maximum concentration (Cmax), and half-life (t1/2) were similar between regimens." | ( Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban. Benincosa, LJ; Di Cicco, RA; Hursting, MJ; Jorkasky, DK; Peng, L; Sheth, SB; Tran, JQ; Tucci, M, 1999) | 0.53 |
| " No significant changes in other theophylline pharmacokinetic parameters were evident." | ( Lack of effect of dirithromycin on theophylline pharmacokinetics in healthy volunteers. Amsden, GW; McConnell, SA; Nafziger, AN, 1999) | 0.3 |
| " The elimination half-life (t1/2beta) was 23." | ( Pharmacokinetics of dirithromycin in patients with mild or moderate cirrhosis. Biagini, MR; Cassetta, MI; Conti, S; Fallani, S; Mazzei, T; Novelli, A; Surrenti, C; Surrenti, E, 1999) | 0.3 |
| "Concomitant administration of diclofenac reduced the partial clearance of quinidine by N-oxidation by 27%, while no effect was found for other pharmacokinetic parameters of quinidine." | ( Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. Brosen, K; Damkier, P; Hansen, LL, 1999) | 0.54 |
| " Amprenavir increased the AUCinfinity of ketoconazole by 44% and increased the drug's half-life and Cmax by 23% and 19%, respectively." | ( Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men. Chittick, GE; Crouch, MA; Gouldin, W; Israel, DS; Lou, Y; Pastor, A; Polk, RE; Sadler, BM; Symonds, WT, 1999) | 0.3 |
| " The findings suggest that sex-specific differences in drug metabolism may occur in both the gut and the liver and involve multiple metabolic pathways and that pharmacokinetic differences will alter pharmacodynamic responses." | ( Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans. Barnas, CR; Jones, MP; Krecic-Shepard, ME; Schwartz, JB; Slimko, J, 2000) | 0.31 |
| " A pharmacokinetic interaction occurs when amprenavir and clarithromycin are coadministered, but the effects are not likely to be clinically important, and coadministration does not require a dosage adjustment for either drug." | ( Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers. Brophy, DF; Chittick, GE; Gillotin, C; Israel, DS; Lou, Y; Pastor, A; Polk, RE; Sadler, BM; Symonds, WT, 2000) | 0.31 |
| " Blood samples were taken at selected times over the next 24 h for pharmacokinetic analysis." | ( The effect of an individual's cytochrome CYP3A4 activity on docetaxel clearance. Baker, LH; Bruno, R; Hirth, J; Schott, A; Strawderman, M; Watkins, PB, 2000) | 0.31 |
| " Maximum plasma peak concentrations, time to maximum concentrations, area under plasma concentration versus time curves, half-life of elimination, and mean residence times were determined from concentration versus time curves." | ( Pharmacokinetics of erythromycin estolate and erythromycin phosphate after intragastric administration to healthy foals. Lakritz, J; Marsh, AE; Mihalyi, JE; Wilson, WD, 2000) | 0.63 |
| "Maximum peak concentration of erythromycin A after administration of erythromycin phosphate was significantly greater than after administration of erythromycin estolate (2." | ( Pharmacokinetics of erythromycin estolate and erythromycin phosphate after intragastric administration to healthy foals. Lakritz, J; Marsh, AE; Mihalyi, JE; Wilson, WD, 2000) | 0.92 |
| " Results pharmacokinetic analysis of plasma concentration-time data for food-withheld and fed conditions were compared." | ( Effects of prior feeding on pharmacokinetics and estimated bioavailability after oral administration of a single dose of microencapsulated erythromycin base in healthy foals. Lakritz, J; Marsh, AE; Mihalyi, JE; Wilson, WD, 2000) | 0.51 |
| " The values for percent 14C exhaled during the first hour (for EBT) and the pharmacokinetic parameters of midazolam (AUC, Cmax, t1/2) were not affected following multiple once-daily oral doses of simvastatin 80 mg." | ( Simvastatin does not affect CYP3A activity, quantified by the erythromycin breath test and oral midazolam pharmacokinetics, in healthy male subjects. Brucker, MJ; Gagliano, K; Gillen, L; Greenberg, HE; McLoughlin, D; Prueksaritanont, T; Rogers, JD; Vega, JM; Waldman, SA; Wong, PH, 2000) | 0.55 |
| "The aim of the present investigation was to study and compare the killing activity of two new fluoroquinolone compounds, moxifloxacin and grepafloxacin, and a new generation macrolide, clarithromycin, against three clinical isolates of Streptococcus pneumoniae (penicillin-susceptible, -intermediate and -resistant) and two Streptococcus pyogenes (erythromycin-susceptible and -resistant) strains by simulating their human pharmacokinetics in a pharmacodynamic model." | ( Bactericidal activity of moxifloxacin compared to grepafloxacin and clarithromycin against Streptococcus pneumoniae and Streptococcus pyogenes investigated using an in vitro pharmacodynamic model. Esposito, S; Ianniello, F; Noviello, S, 2000) | 0.48 |
| "The objective of this study was to determine if there is a pharmacokinetic interaction when amprenavir is given with rifabutin or rifampin and to determine the effects of these drugs on the erythromycin breath test (ERMBT)." | ( Pharmacokinetic Interaction between amprenavir and rifabutin or rifampin in healthy males. Brophy, DF; Chittick, GE; Israel, DS; Kristoff, D; Lou, Y; Patron, R; Polk, RE; Sadler, BM; Stein, DS; Symonds, WT, 2001) | 0.5 |
| " In conclusion, it was demonstrated that DEX pretreatment affects not only P-gp-mediated disposition of Rho123 but also pharmacokinetic interactions of P-gp/CYP3A-related compounds with Rho123, probably because concentrations of substrates/inhibitors at target sites such as the intestine and liver are varied." | ( Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone. Murakami, T; Nagai, J; Nasu, R; Sanemasa, M; Takano, M; Yumoto, R, 2001) | 0.31 |
| "05) increased the mean Cmax value (1." | ( The effects of grapefruit juice on the pharmacokinetics of erythromycin. Kanazawa, S; Ohkubo, T; Sugawara, K, ) | 0.37 |
| "Our objective was to investigate ethnic differences in the oral pharmacokinetics of nifedipine and erythromycin, both typical cytochrome P4503A (CYP3A) substrates, in Koreans and Caucasians and to identify the nature of any correlations between the pharmacokinetic parameters of the two drugs." | ( Ethnic differences and relationships in the oral pharmacokinetics of nifedipine and erythromycin. Bae, KS; Cho, JY; Jang, IJ; Lim, HS; Shin, SG; Shon, JH; Yi, SY; Yu, KS, 2001) | 0.75 |
| " Pharmacokinetic evaluations were performed, and parameters were compared for the two ethnic groups." | ( Ethnic differences and relationships in the oral pharmacokinetics of nifedipine and erythromycin. Bae, KS; Cho, JY; Jang, IJ; Lim, HS; Shin, SG; Shon, JH; Yi, SY; Yu, KS, 2001) | 0.54 |
| " Hemodynamic changes after nifedipine administration paralleled those of the pharmacokinetic differences, with significantly greater decreases in blood pressure and total peripheral resistance noted in Koreans." | ( Ethnic differences and relationships in the oral pharmacokinetics of nifedipine and erythromycin. Bae, KS; Cho, JY; Jang, IJ; Lim, HS; Shin, SG; Shon, JH; Yi, SY; Yu, KS, 2001) | 0.54 |
| " Population pharmacokinetic analysis was performed using the NONMEM computer program." | ( Pharmacokinetics of ABT-773, a new semi-synthetic ketolide in neutropenic lung-infected mice: a population approach. Kim, M; Nicolau, DP; Nightingale, CH; Xuan, D; Ye, M, 2002) | 0.31 |
| "Repeated dosing with erythromycin caused statistically significant increases in the AUC and Cmax of sildenafil (2." | ( The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers. Faulkner, S; Harness, JA; Muirhead, GJ; Taubel, J, 2002) | 0.93 |
| "Effects of altered plasma alpha-1-acid glycoprotein (AGP) levels on pharmacokinetic parameters of basic antimicrobials, erythromycin (EM), lincomycin (LM) and clindamycin (CM) were evaluated in pigs by simulation analysis." | ( Effects of altered plasma alpha-1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis. Kuroha, M; Shimoda, M; Son, DS, 2001) | 0.52 |
| " pneumoniae in a murine pneumonia model and to describe the pharmacodynamic (PD) profile of cethromycin." | ( Bactericidal effect and pharmacodynamics of cethromycin (ABT-773) in a murine pneumococcal pneumonia model. Kim, MK; Nicolau, DP; Nightingale, CH; Tessier, PR; Xuan, D; Ye, M; Zhou, W, 2002) | 0.31 |
| " The outflow patterns of clarithromycin or erythromycin at various inflow concentrations were simultaneously analysed based on a pharmacokinetic model, which consists of the non-specific binding site, the specific binding site and the subsequent uptake process." | ( Pharmacokinetic evaluation of high pulmonary disposition of clarithromycin after systemic administration. Hamabe, M; Higaki, K; Kimura, T; Kubo, JI; Ogawara, KI; Ohigashi, Y; Saito, H, 2002) | 0.58 |
| "Erythromycin caused statistically significant, although limited, modifications of lignocaine and MEGX pharmacokinetic parameters." | ( Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function. De Martin, S; Orlando, R; Padrini, R; Palatini, P; Piccoli, P, 2003) | 2.05 |
| " A pharmacodynamic study following lignocaine infusion to steady state appears necessary to assess the actual clinical relevance of these combined effects." | ( Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function. De Martin, S; Orlando, R; Padrini, R; Palatini, P; Piccoli, P, 2003) | 0.6 |
| " Plasma concentrations of voriconazole were measured up to 12 h postdose on days 7 and 14, and plasma pharmacokinetic parameters were calculated." | ( No clinically significant effect of erythromycin or azithromycin on the pharmacokinetics of voriconazole in healthy male volunteers. Ghahramani, P; Kleinermans, D; Layton, G; Nichols, D; Purkins, L; Wood, N, 2003) | 0.59 |
| "Comparison of the voriconazole Cmax day 14/day 7 ratio for the voriconazole + erythromycin group with that of the voriconazole + placebo group yielded a ratio of 107." | ( No clinically significant effect of erythromycin or azithromycin on the pharmacokinetics of voriconazole in healthy male volunteers. Ghahramani, P; Kleinermans, D; Layton, G; Nichols, D; Purkins, L; Wood, N, 2003) | 0.82 |
| " Ocular pharmacokinetic studies were conducted using a topical single-dose infusion method." | ( Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption. Dey, S; Gunda, S; Mitra, AK, 2004) | 0.65 |
| "The objective of this study was to determine the steady-state plasma and intrapulmonary pharmacokinetic parameters of orally administered cethromycin in healthy volunteers." | ( Steady-state plasma and intrapulmonary pharmacokinetics and pharmacodynamics of cethromycin. Conte, JE; Golden, JA; Kipps, J; Zurlinden, E, 2004) | 0.32 |
| " Using 3P87 we analyzed the model and calculated the pharmacokinetic parameters." | ( [Pharmacokinetics of erythromycin stinoprate capsule]. Cheng, ZN; Guo, X; Hu, ZY; Huang, ZZ; Wang, LQ; Xiong, J; Yu, Q, 2005) | 0.65 |
| "Human pharmacokinetic parameters are often predicted prior to clinical study from in vivo preclinical pharmacokinetic data." | ( Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Jolivette, LJ; Ward, KW, 2005) | 0.33 |
| " Here we present a unique, generic, physiologically based pharmacokinetic (PBPK) model and demonstrate its application to the estimation of rat plasma pharmacokinetics, following intravenous dosing, from in vitro data alone." | ( Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in rat plasma. Brightman, FA; Leahy, DE; Searle, GE; Thomas, S, 2006) | 0.33 |
| "A pharmacokinetic interaction between erythromycin and ximelagatran, an oral direct thrombin inhibitor, was demonstrated in this study in healthy volunteers." | ( Influence of erythromycin on the pharmacokinetics of ximelagatran may involve inhibition of P-glycoprotein-mediated excretion. Dorani, H; Eriksson, UG; Fritsch, H; Hoffmann, KJ; Karlsson, J; Olsson, L; Sarich, TC; Schützer, KM; Wall, U, 2006) | 0.97 |
| " We studied the interaction between verapamil and erythromycin in the rat to see whether it occurs at the pharmacokinetics or pharmacodynamic level." | ( Erythromycin potentiates PR interval prolonging effect of verapamil in the rat: a pharmacodynamic drug interaction. Dakhel, Y; Jamali, F, 2006) | 2.03 |
| " During the fluvoxamine phase the area under the plasma concentration-time curve (AUC) and peak concentration (Cmax) of oral lidocaine were 305% (P<0." | ( Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine. Isohanni, MH; Neuvonen, PJ; Olkkola, KT, 2006) | 0.63 |
| " The aim of the present study was to develop a semimechanistic pharmacokinetic (PK)/pharmacodynamic (PD) model characterizing the events seen in a bacterial system when it is exposed to antibacterial agents with different mechanisms of action." | ( Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments. Cars, O; Karlsson, MO; Löwdin, E; Nielsen, EI; Sandström, M; Viberg, A, 2007) | 0.34 |
| " A simple, widely used E(max) model was not sufficient to describe the pharmacodynamic effects for the four bacterial strains." | ( Pharmacokinetic/pharmacodynamic modeling of in vitro activity of azithromycin against four different bacterial strains. Derendorf, H; Rand, KH; Schmidt, S; Suvanakoot, U; Treyaprasert, W, 2007) | 0.34 |
| " Bayesian designed limited pharmacokinetic data were collected from an additional 41 patients." | ( Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma. Baker, LH; Chugh, R; Griffith, KA; Leu, KM; Taylor, JM; Thomas, DG; Wagner, T; Worden, FP; Zalupski, MM, 2007) | 0.55 |
| " ERMBT was not found to correlate with pharmacokinetic parameters of ifosfamide and metabolites or toxicity." | ( Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma. Baker, LH; Chugh, R; Griffith, KA; Leu, KM; Taylor, JM; Thomas, DG; Wagner, T; Worden, FP; Zalupski, MM, 2007) | 0.55 |
| " HPLC of the erythromycin pharmacokinetic pattern in 20 patients showed that after the antibiotic target transport the pharmacokinetic model changed from one-compartment to two-compartment one and the antibiotic maximum concentration and elimination rate were lower vs." | ( [Comparative pharmacokinetics of erythromycin target cell-associated transport and intravenous administration in patients with pneumonia]. Beliaev, AN; Gurevich, KG; Piataev, NA; Romanov, MD, 2006) | 0.98 |
| "6-times and 9-times published Cmax tear and conjunctival concentration, respectively)." | ( The pharmacodynamic properties of azithromycin in a kinetics-of-kill model and implications for bacterial conjunctivitis treatment. Bell, B; Dorfman, MS; Jamison, T; Stroman, DW; Wagner, RS, 2008) | 0.35 |
| " pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data." | ( Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Lombardo, F; Obach, RS; Waters, NJ, 2008) | 0.35 |
| " The purpose of this study was to further evaluate the safety and pharmacokinetic profile of a range of diflomotecan doses administered intravenously." | ( A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. Cendros, JM; Evans, TR; Falk, S; Graham, JS; Samuel, LM, 2009) | 0.35 |
| " Pharmacokinetic analyses were performed on serial blood samples taken over the first 24 h after diflomotecan administration (cycles 1 and 2)." | ( A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. Cendros, JM; Evans, TR; Falk, S; Graham, JS; Samuel, LM, 2009) | 0.35 |
| " Pharmacokinetic analyses revealed a less than dose-proportional increase in diflomotecan and for the two metabolites BN80942 and P-20, with a magnitude of P-20 exposure similar to the parent drug." | ( A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. Cendros, JM; Evans, TR; Falk, S; Graham, JS; Samuel, LM, 2009) | 0.35 |
| "Diflomotecan administered as a 20-min intravenous infusion 3-weekly is characterised by a variable pharmacokinetic profile." | ( A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. Cendros, JM; Evans, TR; Falk, S; Graham, JS; Samuel, LM, 2009) | 0.35 |
| " It has good preclinical pharmacokinetic properties across multiple species and potent in vitro and in vivo activity against respiratory tract infection pathogens, including Haemophilus influenzae, atypical organisms (e." | ( Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. Jiang, LJ; Or, YS; Wang, M, 2009) | 0.35 |
| "African green monkeys (vervets) have been proposed as an alternate species that might allow improved access and provide high-quality pharmacokinetic results comparable with other primates." | ( Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug-drug interactions. Bhadresa, S; Coon, DJ; Lawrence, MS; Magiera, D; Struharik, M; Ward, KW, 2009) | 0.35 |
| "After co-administration of erythromycin and roflumilast, the mean AUC and Cmax of roflumilast increased by 70% and 40%, respectively." | ( Effect of repeated dose of erythromycin on the pharmacokinetics of roflumilast and roflumilast N-oxide. Elmlinger, M; Hermann, R; Herzog, R; Huennemeyer, A; Lahu, G; McCracken, N; Zech, K, 2009) | 0.95 |
| " TGC displayed linear PK and had a mean half-life of 10." | ( Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. Banevicius, MA; Crandon, JL; Koomanachai, P; Nicolau, DP; Peng, L, 2009) | 0.35 |
| " Pharmacokinetic interactions may result in the increase or the decrease of plasma drug concentrations." | ( [Mechanisms of pharmacokinetic drug-drug interactions]. Beretz, L; Coliat, P; Lemachatti, J; Levêque, D; Nivoix, Y; Santucci, R; Ubeaud-Séquier, G; Vinzio, S, 2010) | 0.36 |
| "The aim of this study was to characterise the pharmacokinetic properties of different formulations of erythromycin in cats." | ( Pharmacokinetics of erythromycin after intravenous, intramuscular and oral administration to cats. Albarellos, GA; Landoni, MF; Montoya, L, 2011) | 0.91 |
| " Route-randomized, two-way crossover pharmacokinetic studies of ER were conducted in 12 ESRD patients and 12 healthy controls after oral (250 mg) and intravenous (125 mg) dosing with ER." | ( Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Benet, LZ; Frassetto, LA; Huang, Y; Sun, H, 2010) | 0.62 |
| "To develop a semi-mechanistic population pharmacokinetic model based on gastric emptying function for acetaminophen plasma concentration in critically ill patients tolerant and intolerant to enteral nutrition before and after prokinetic therapy." | ( A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients. Aarons, L; Dukes, G; Maclaren, R; Ogungbenro, K; Vasist, L; Young, M, 2011) | 0.37 |
| " Population pharmacokinetic modelling was carried out in a nonlinear mixed effects analysis software, NONMEM." | ( A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients. Aarons, L; Dukes, G; Maclaren, R; Ogungbenro, K; Vasist, L; Young, M, 2011) | 0.37 |
| "The four-compartment semi-mechanistic population pharmacokinetic model adequately described the data." | ( A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients. Aarons, L; Dukes, G; Maclaren, R; Ogungbenro, K; Vasist, L; Young, M, 2011) | 0.37 |
| "The pharmacokinetic effects of substrates or inhibitors of CYP3A4, P-gp and Bcrp (ABCG2) on rivaroxaban were studied in healthy volunteers." | ( Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects. Becka, M; Kubitza, D; Mueck, W, 2013) | 0.39 |
| " Serial blood samples were collected over the course of the two studies and pharmacokinetic parameters were determined for all analytes." | ( Effect of netupitant, a highly selective NK₁ receptor antagonist, on the pharmacokinetics of midazolam, erythromycin, and dexamethasone. Lanzarotti, C; Rossi, G, 2013) | 0.6 |
| "This is an open-label, prospective pharmacokinetic study evaluating CYP3A activity using The Erythromycin Breath Test." | ( Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis. Alffenaar, JW; Buchard, A; Dalbøge, CS; Dalhoff, K; Duno, M; Høiby, N; Jensen, AG; Johansen, HK; Jürgens, G; Nielsen, XC; Pressler, T; Uges, DR, 2014) | 0.62 |
| "Geometric mean Cmax and AUCs of UPA were increased by 24% [geometric mean ratio point estimate (90% CI): 1·24 (1·01-1·52)] and +224% and +227% [geometric mean ratio point estimates (90% CI): AUC0-t 3·24 (2·75-3·83) and AUC0-∞ (3·27 (2·79-3·83)], respectively, with no effect on median tmax or t1/2." | ( Effects of erythromycin at steady-state concentrations on the pharmacokinetics of ulipristal acetate. Gotteland, JP; Osterloh, I; Pohl, O, 2013) | 0.78 |
| "Concomitant use of ulipristal acetate with erythromycin at therapeutic concentrations led to a limited increase in Cmax and a 3-fold increase in AUCs for UPA and to a decrease in Cmax and an increase in AUCs and prolonged elimination for PGL4002." | ( Effects of erythromycin at steady-state concentrations on the pharmacokinetics of ulipristal acetate. Gotteland, JP; Osterloh, I; Pohl, O, 2013) | 1.04 |
| " When combined, the co-administration of rivaroxaban 10 mg with SS erythromycin in subjects with mild or moderate RI produced mean increases in rivaroxaban AUC∞ and Cmax of approximately 76% and 56%, and 99% and 64%, respectively, relative to NRF subjects, with PD changes displaying a similar trend." | ( An open-label study to estimate the effect of steady-state erythromycin on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban in subjects with renal impairment and normal renal function. Ariyawansa, J; Haskell, L; Moore, KT; Natarajan, J; Turner, KC; Vaidyanathan, S, 2014) | 0.88 |
| "Physiologically based pharmacokinetic modeling was applied to characterize the potential drug-drug interactions for ruxolitinib." | ( Predicting drug-drug interactions involving multiple mechanisms using physiologically based pharmacokinetic modeling: a case study with ruxolitinib. Fraczkiewicz, G; Shi, JG; Williams, WV; Yeleswaram, S, 2015) | 0.42 |
| "Volume of distribution is one of the most important pharmacokinetic properties of a drug candidate." | ( Volume of Distribution in Drug Design. Beaumont, K; Di, L; Maurer, TS; Smith, DA, 2015) | 0.42 |
| " Pharmacokinetic parameters were estimated from concentration-time data using standard noncompartmental methods." | ( Effect of the gastrointestinal prokinetic agent erythromycin on the pharmacokinetics of pregabalin controlled-release in healthy individuals: a phase I, randomized crossover trial. Alebic-Kolbah, T; Alvey, CW; Bockbrader, HN; Chew, ML; Pitman, VW; Plotka, A; Scavone, JM, 2015) | 0.67 |
| "To assess the effect of strong and moderate cytochrome P450 (CYP) 3A4 inhibition on exposure of bitopertin, a glycine reuptake inhibitor primarily metabolized by CYP3A4, and to compare the results with predictions based on physiologically based pharmacokinetic (PBPK) modelling." | ( Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions. Banken, L; Boetsch, C; Fowler, S; Hainzl, D; Hofmann, C; Martin-Facklam, M; Parrott, N; Poirier, A, 2016) | 0.68 |
| " Pharmacokinetic parameters were derived by non-compartmental methods." | ( Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions. Banken, L; Boetsch, C; Fowler, S; Hainzl, D; Hofmann, C; Martin-Facklam, M; Parrott, N; Poirier, A, 2016) | 0.68 |
| " The peak concentration (C max) increased by <25 % in both studies." | ( Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions. Banken, L; Boetsch, C; Fowler, S; Hainzl, D; Hofmann, C; Martin-Facklam, M; Parrott, N; Poirier, A, 2016) | 0.68 |
| " A physiologically based pharmacokinetic model was developed to describe DDIs between domperidone and three different inhibitors of CYP3A4." | ( A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4. Ravenstijn, P; Sensenhauser, C; Snoeys, J; Templeton, I, 2016) | 0.43 |
| "A physiologically based pharmacokinetic (PBPK) model was developed for cobimetinib using in vitro data." | ( Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. Budha, NR; Chen, Y; Dresser, M; Eppler, S; Ji, T; Jin, JY; Musib, L, 2016) | 0.43 |
| "The PBPK model described cobimetinib pharmacokinetic profiles after both intravenous and oral administration of cobimetinib well and accurately simulated the itraconazole-cobimetinib DDI." | ( Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. Budha, NR; Chen, Y; Dresser, M; Eppler, S; Ji, T; Jin, JY; Musib, L, 2016) | 0.43 |
| " The results of clinical pharmacokinetic (PK) studies indicate that guanfacine is sensitive to drug-drug interactions (DDIs) perpetrated by strong inhibitors and inducers of CYP3A4." | ( Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug-Drug Interactions with Moderate CYP3A4 Inhibitors or Inducers. Li, A; Rong, H; Welty, D; Yeo, K, 2018) | 0.48 |
| " A physiologically based pharmacokinetic (PBPK) model was established to evaluate the changes in the ruxolitinib systemic exposures with co-administration of CYP3A4 and CYP2C9 perpetrators." | ( Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions. Aslanis, V; He, H; Heimbach, T; Huth, F; Jin, Y; Schiller, H; Umehara, K, 2019) | 0.51 |
| " The aims of this study were to develop and evaluate population pharmacokinetic (PPK) models of caffeine in preterm infants through comprehensive screening of covariates and then to propose model-informed precision dosing of caffeine for this population." | ( Population pharmacokinetic modeling of caffeine in preterm infants with apnea of prematurity: New findings from concomitant erythromycin and AHR genetic polymorphisms. Chen, F; Cheng, R; Dai, HR; Ding, XS; Guo, HL; He, X; Hu, YH; Jiao, Z; Liu, Y; Lu, KY; Xu, J, 2022) | 0.93 |
In vitro effects of spectinomycin and ceftriaxone, alone or in combination with erythromycin, ofloxacin, and doxycycline, against Chlamydia trachomatis were investigated by the checkerboard method. Blood induced Plasmodium berghei infection in Swiss mice was exposed during successive passages to melfloquine alone or melfoquine in combinations with dapsone or primaquine.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The activity of TLC G-65 (a liposomal gentamicin preparation), alone and in combination with rifapentine, clarithromycin, clofazimine and ethambutol, was evaluated in the beige mouse (C57BL/6J--bgj/bgj) model of disseminated Mycobacterium avium infection." | ( TLC G-65 in combination with other agents in the therapy of Mycobacterium avium infection in beige mice. Cynamon, MH; Klemens, SP; Swenson, CE, 1992) | 0.28 |
| "The activity of clarithromycin in combination with ethambutol and rifampicin was tested at concentrations achievable in serum against 20 strains of Mycobacterium avium complex." | ( In vitro testing of clarithromycin in combination with ethambutol and rifampicin against Mycobacterium avium complex. Dörtbudak, O; Lahonik, E; Stauffer, F, ) | 0.13 |
| " When clarithromycin was tested against three MAC strains in combination with another drug, it showed a synergistic effect only when combined with rifampicin." | ( In vitro activity of clarithromycin alone or in combination with other antimicrobial agents against Mycobacterium avium-intracellulare. Complex strains isolated from AIDS patients. De Gregoris, P; Fattorini, L; Hu, CQ; Iona, E; Mascellino, MT; Orefici, G; Santoro, C, 1991) | 0.28 |
| " We have characterized PCN or macrolides induced cytochromes P-450 by their specific ability to interact with macrolide derivatives and, using the cytochrome P-450 spectral binding assays, we have shown that some compounds, implicated in drug interaction with macrolides, interact preferentially with the same cytochromes." | ( Specific drug binding to rat liver cytochrome P-450 isozymes induced by pregnenolone-16 alpha-carbonitrile and macrolide antibiotics. Implications for drug interactions. Delaforge, M; Sartori, E, 1990) | 0.28 |
| "A study was performed to determine if the pharmacokinetics of bromocriptine is altered by factors that have been shown to interact with other ergot compounds." | ( Pharmacokinetic evaluation of erythromycin and caffeine administered with bromocriptine. Berchou, RC; Kareti, D; LeWitt, PA; Nelson, MV, 1990) | 0.57 |
| "Blood induced Plasmodium berghei infection in Swiss mice was exposed during successive passages to melfloquine alone or melfoquine in combination with dapsone or primaquine or erythromycin, and the level of resistance to melfoquine in four sub-lines was compared at ED90 level." | ( Delay in emergence of mefloquine resistance in Plasmodium berghei by use of drug combinations. Dutta, GP; Puri, SK, 1989) | 0.47 |
| "The effect of amikacin and two new macrolides (roxithromycin and azithromycin) used either alone or in combination with recombinant tumor necrosis factor (TNF) to inhibit or kill Mycobacterium avium complex in human macrophages was examined in vitro." | ( Activities of amikacin, roxithromycin, and azithromycin alone or in combination with tumor necrosis factor against Mycobacterium avium complex. Bermudez, LE; Young, LS, 1988) | 0.27 |
| " In the present study, ten patients with falciparum malaria were given large doses of erythromycin, combined with standard doses of chloroquine; the cure rate was 0 out of 10 (4 RIII failures, 6 RII failures)." | ( Failure of large-dose erythromycin in combination with a standard dose of chloroquine or quinine in the treatment of human falciparum malaria. Boudreau, EF; Childs, GE; Pang, LW; Somutsakorn, P; Supanantalerk, C; Webster, HK, 1985) | 0.81 |
| "Since the optimal antimicrobial therapy for infections caused by Listeria monocytogenes, particularly in patients allergic to penicillin, is uncertain, we investigated the in vitro effects of erythromycin, alone and in combination with other antibiotics, on listeriae." | ( Effects of erythromycin in combination with penicillin, ampicillin, or gentamicin on the growth of Listeria monocytogenes. Penn, RL; Steigbigel, RT; Ward, TT, 1982) | 0.84 |
| " Brief information on the following reports of drug-drug interactions is given in this article with the intention of giving these reports wider publicity and, possibly, encouraging further observation and research to establish or disprove their validity in a larger and wider range of patients or volunteer subjects." | ( Early reports on drug interactions. D'Arcy, PF, 1983) | 0.27 |
| "Glycoside antibiotics including the macrolide antibiotics azithromycin, clarithromycin, and erythromycin and the aminoglycoside paromomycin were administered alone or combined with doxycycline, minocycline, or tetracycline to neonatal BALB/c mice experimentally infected with Cryptosporidium parvum." | ( Glycoside antibiotics alone and combined with tetracyclines for prophylaxis of experimental cryptosporidiosis in neonatal BALB/c mice. Ellis, W; Fayer, R, 1993) | 0.51 |
| " By decreasing their metabolism, erythromycin can interact with other drugs metabolized by the cytochrome P450 enzymes." | ( Drug interactions of macrolides: emphasis on dirithromycin. Polk, RE; Stotka, JL; Watkins, VS, 1997) | 0.58 |
| " Five days a week, the three materials (benzoyl peroxide, clindamycin phosphate, and erythromycin) were applied in a nonocclusive manner either alone or in combination with adapalene gel on seven cutaneous sites on the upper back." | ( Skin tolerance of adapalene 0.1% gel in combination with other topical antiacne treatments. Caron, D; Clucas, A; Sorba, V; Verschoore, M, 1997) | 0.52 |
| " Erythromycin has the potential to interact with many medications by inhibiting drug metabolism in the liver." | ( Erythromycin: drug interactions. Gurevitz, SL, 1997) | 2.65 |
| "001) and proportion of patients being discharged under treatment with a dangerous drug combination (36." | ( Impact of a Web-based clinical information system on cisapride drug interactions and patient safety. Bailey, TC; Frisse, ME; McMullin, ST; Reichley, RM; Steib, SA; Watson, LA, 1999) | 0.3 |
| "The efficacy of levofloxacin and dirithromycin, alone and in combination with rifampicin in the treatment of experimental brucellosis was investigated." | ( Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus infection. Arda, B; Gökengin, D; Gürel, O; Tunçel, M; Yaimazhan, T, 2004) | 0.32 |
| " The drug-drug interaction responsible for CYP3A enzyme(s) inhibition was observed when midazolam and inhibitors were co-administrated orally." | ( Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans. Baba, T; Kanazu, T; Koike, M; Okamura, N; Yamaguchi, Y, 2004) | 0.32 |
| " He was diagnosed as having acute respiratory distress syndrome due to severe pneumonia, and was treated with pulse methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin." | ( [A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin]. Arinobu, Y; Himeji, D; Kikuchi, I; Kojima, T; Oguma, A; Ueda, A, 2004) | 0.71 |
| "The in vitro effects of spectinomycin and ceftriaxone, alone or in combination with erythromycin, ofloxacin, and doxycycline, against Chlamydia trachomatis were investigated by the checkerboard method and compared by Ridit (reference identical unit) analysis." | ( In vitro effects of spectinomycin and ceftriaxone alone or in combination with other antibiotics against Chlamydia trachomatis. Gong, X; Mabey, D; Shang, S; Wang, Q; Xia, L; Zhang, J; Zhao, J; Zhong, M, 2005) | 0.55 |
| "Time-dependent inhibition of CYP3A4 often results in clinically significant drug-drug interactions." | ( Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition. Burt, H; Galetin, A; Gibbons, L; Houston, JB, 2006) | 0.33 |
| " A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin." | ( In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. Cirioni, O; Della Vittoria, A; Giacometti, A; Kamysz, W; Licci, A; Okroj, M; Scalise, G; Silvestri, C, 2007) | 0.34 |
| "The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated." | ( In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes. Kim, IH; Lim, YH; Seo, JJ, 2007) | 0.75 |
| " Meanwhile, the effects described above were enhanced when garlicin was combined with erythromycin." | ( [Mechanism reversing MDR of K562/A02 by garlicin combined with erythromycin]. Chen, W; Liu, X; Wang, H; Xu, B; Yu, M, 2008) | 0.81 |
| " To assess drug-drug interactions, co-administration experiments were conducted with ketoconazole and either propranolol or erythromycin." | ( Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug-drug interactions. Bhadresa, S; Coon, DJ; Lawrence, MS; Magiera, D; Struharik, M; Ward, KW, 2009) | 0.56 |
| "Pharmacokinetic drug-drug interactions occur when a drug alters the disposition (absorption, distribution, elimination) of a coadministered agent." | ( [Mechanisms of pharmacokinetic drug-drug interactions]. Beretz, L; Coliat, P; Lemachatti, J; Levêque, D; Nivoix, Y; Santucci, R; Ubeaud-Séquier, G; Vinzio, S, 2010) | 0.36 |
| "The in vitro antimicrobial activities of usnic acid were evaluated in combination with five therapeutically available antibiotics, using checkerboard microdilution assay against methicillin-resistant clinical isolates strains of Staphylococcus aureus." | ( In vitro interaction of usnic acid in combination with antimicrobial agents against methicillin-resistant Staphylococcus aureus clinical isolates determined by FICI and ΔE model methods. Amicosante, G; Bellio, P; Brisdelli, F; Celenza, G; Garbarino, JA; Nicoletti, M; Perilli, M; Piovano, M; Segatore, B; Setacci, D, 2012) | 0.38 |
| "Inhibition of cytochrome P450-mediated drug metabolism by a concomitantly administered second drug is one of the major causes of drug-drug interactions in humans." | ( Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4. Di Nardo, G; Ferrero, S; Gilardi, G; Sadeghi, SJ, 2012) | 0.38 |
| "The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions." | ( Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR, 2012) | 0.38 |
| "A total of 30 chalcone analogues was synthesized via a base catalyzed Claisen Schmidt condensation and screened for their in vitro antibacterial activity against Methicillin-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA) alone or in combination with non beta-lactam antibiotics namely ciprofloxacin, chloramphenicol, erythromycin, vancomycin, doxycycline and gentamicin." | ( Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. Do, TH; Huynh, TN; Ngo, TD; Thai, KM; Tran, CD; Tran, NC; Tran, TD, 2012) | 0.55 |
| "Physiologically based pharmacokinetic modeling was applied to characterize the potential drug-drug interactions for ruxolitinib." | ( Predicting drug-drug interactions involving multiple mechanisms using physiologically based pharmacokinetic modeling: a case study with ruxolitinib. Fraczkiewicz, G; Shi, JG; Williams, WV; Yeleswaram, S, 2015) | 0.42 |
| "While co-administered gemfibrozil can increase the area under the concentration/time curve (AUC) of pioglitazone more than 3-fold, the underlying mechanism of the drug-drug interaction between gemfibrozil and pioglitazone has not been fully understood." | ( Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil: Gemfibrozil acyl-glucuronide is a mechanism-based inhibitor of CYP2C8. Fujiwara, R; Itoh, T; Sakamoto, M; Takagi, M, 2015) | 0.42 |
| "Domperidone is a dopamine receptor antagonist and a substrate of CYP3A4, hence there is a potential for CYP3A inhibition-based drug-drug interactions (DDI)." | ( A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4. Ravenstijn, P; Sensenhauser, C; Snoeys, J; Templeton, I, 2016) | 0.43 |
| " In this work, the proteome responses in MRSA under the stress of a sub-inhibitory dose of a synergistic drug combination of a novel erythromycin derivative, SIPI-8294, and oxacillin, were studied by label-free quantitative proteomics." | ( Proteomic response of methicillin-resistant S. aureus to a synergistic antibacterial drug combination: a novel erythromycin derivative and oxacillin. Chen, D; Dong, X; Hu, Y; Lam, H; Liu, X; Pai, PJ; Qian, PY; Zhang, W, 2016) | 0.85 |
| " However, 5-formylisochromen-1-one (4), (-)-mellein (8), and swermacrolactone C (9) exhibited potent antimycobacterial activities against Mycobacterium smegmatis when used in combination with the antibiotic drug erythromycin." | ( Constituents of Fagraea fragrans with Antimycobacterial Activity in Combination with Erythromycin. Chakthong, S; Cheyeng, N; Chusri, S; Heembenmad, S; Madmanang, S; Mahabusarakam, W; Saising, J; Seeger, M, 2016) | 0.84 |
| " A clinical drug-drug interaction (DDI) study with the potent CYP3A4 inhibitor itraconazole resulted in an approximately sevenfold increase in cobimetinib exposure." | ( Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. Budha, NR; Chen, Y; Dresser, M; Eppler, S; Ji, T; Jin, JY; Musib, L, 2016) | 0.43 |
| " Three edoxaban drug-drug interaction studies examined the effects of P-gp inhibitors with varying degrees of CYP3A4 inhibition." | ( Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. Matsushima, N; Mendell, J; Parasrampuria, DA; Shi, M; Truitt, K; Zahir, H, 2016) | 0.69 |
| " The results of clinical pharmacokinetic (PK) studies indicate that guanfacine is sensitive to drug-drug interactions (DDIs) perpetrated by strong inhibitors and inducers of CYP3A4." | ( Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug-Drug Interactions with Moderate CYP3A4 Inhibitors or Inducers. Li, A; Rong, H; Welty, D; Yeo, K, 2018) | 0.48 |
| "Erythromycin combined with budesonide may reduce inflammation and modify fibrosis progression in TS after tracheal injury." | ( Erythromycin combined with corticosteroid reduced inflammation and modified trauma-induced tracheal stenosis in a rabbit model. Changchun, H; Enyuan, Q; Guangnan, L; Jinghua, G; Lei, Z; Lihua, L; Luoman, G; Mingpeng, X; Wentao, L; Xiaoyan, M; Yu, L, ) | 3.02 |
| "Potential drug-drug interactions of the antitumor drug abiraterone and the macrolide antibiotic erythromycin were studied at the stage of cytochrome P450 3A4 (CYP3A4) biotransformation." | ( In vitro interactions of abiraterone, erythromycin, and CYP3A4: implications for drug-drug interactions. Archakov, AI; Dmitriev, AV; Filimonov, DA; Gilep, AA; Haurychenka, YI; Kuzikov, AV; Masamrekh, RA; Shcherbakov, KA; Shkel, TV; Shumyantseva, VV; Strushkevich, NV; Usanov, SA; Veselovsky, AV; Zavialova, MG, 2020) | 1.05 |
| " An integrated in silico, in vitro, and clinical approach including a clinical drug interaction study as well as a bespoke physiologically based pharmacokinetic (PBPK) model was used to assess the drug-drug interaction (DDI) risk." | ( Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations. Cahn, AP; Georgiou, A; Harrell, AW; Hessel, EM; Marotti, M; Patel, A; Riddell, K; Taskar, KS; Taylor, M; Tracey, H; Wilson, R, 2020) | 0.56 |
| "In the present study the electrochemical system based on recombinant cytochrome P450 3A4 (CYP3A4) was used for the investigation of potential drug-drug interaction between medicinal preparations employed for Helicobacter pylori eradication therapy." | ( [Modeling of drug-drug interactions between omeprazole and erythromycin with cytochrome P450 3A4 in vitro assay]. Bulko, TV; Dmitriev, AV; Filimonov, DA; Gilep, AA; Koroleva, PI; Kuzikov, AV; Makhova, AA; Masamrekh, RA; Rikova, SM; Shich, EV; Shumyantseva, VV; Zaviyalova, MG, 2020) | 0.8 |
| " In this study, a new method for the microplastics quantitatively and qualitatively analysis by two-phase (ethyl acetate-water) system combined with confocal Raman spectroscopy was developed." | ( Separation of false-positive microplastics and analysis of microplastics via a two-phase system combined with confocal Raman spectroscopy. Chang, M; Dai, Z; Hong, P; Hu, J; Jiang, WY; Li, C; Liang, YQ; Liao, Y; Liu, Y; Lu, Z; Qian, ZJ; Ren, L; Sun, R; Sun, S; Yang, J; Zhang, Y; Zhou, C, 2022) | 0.72 |
Theophylline plasma levels and bioavailability are higher after simultaneous erythromycin dosing. ABT-229 was > 300,000 times more potent than erythyromycin in vitro and had 39% oral bioavailability in dog.
| Excerpt | Reference | Relevance |
|---|---|---|
| " The effect of food on the bioavailability of two new formulations of erythromycin, 1) erythromycin stearate, 500 mg (Erythrocin, 250 mg capsule-shaped tablets) and 2) erythromycin base, 500 mg (Eryc, 250 mg capsules containing enteric-coated pellets) was studied in 16 healthy subjects." | ( The influence of food on the bioavailability of new formulations of erythromycin stearate and base. Berend, N; Marlin, GE; Rutland, J, 1979) | 0.73 |
| " Statistical analysis of variance was performed on the observed bioavailability parameters: maximum serum concentration (Cmax), time to maximum serum concentration (Tmax), and area under the serum concentration-time curve (AUC)." | ( Single-dose fasting bioequivalence assessment of erythromycin stearate tablets in man. Briggs, AH; Doluisio, JT; Harris, RG; Leonard, RG; Martin, A; Poynor, WJ; Yakatan, GJ, 1979) | 0.51 |
| "A parallel treatment group bioavailability study was undertaken in children 6 to 65 months of age, comparing fasting and nonfasting erythromycin serum levels after a single oral dose of erythromycin ethylsuccinate granules." | ( Bioavailability of erythromycin ethylsuccinate in pediatric patients. Chun, AH; Coyne, TC; Jeansonne, L; Shirkey, HC; Shum, S, 1978) | 0.79 |
| "The influence of various test meals and coadministered water volumes on erythromycin stearate bioavailability from orally dosed film-coated tablets was studied in healthy human subjects." | ( Bioavailability of erythromycin stearate: influence of food and fluid volume. Hewitt, PF; Huang, H; Lyons, LL; Welling, PG, 1978) | 0.82 |
| " The bioavailability of the third dose of erythromycin on a given day is considerably lower than that of the second dose or of the fourth and last dose of the day." | ( Pharmacokinetics of erythromycin on repetitive dosing. Colburn, WA; Di Santo, AR; Gibaldi, M, 1977) | 0.84 |
| " As the conclusion, OE-7 revealed good bioavailability and seemed to be useful antibiotic for acute respiratory infections." | ( [Studies on erythromycin stearate capsules (OE-7) (author's transl)]. Nishiyama, M; Tsubura, E; Yamashita, T, 1976) | 0.63 |
| " Studies with rats indicated that the compounds were well absorbed and rapidly excreted in the urine." | ( The metabolism of labelled hexadecyl sulphate salts in the rat, dog and human. Merits, I, 1975) | 0.25 |
| " They offer improved bioavailability and an extended half-life." | ( The new macrolide antibiotics. Azithromycin and clarithromycin. Havlichek, DH; Stein, GE, 1992) | 0.28 |
| " They are well absorbed and widely distributed, with excellent cellular and tissue penetration." | ( New macrolide antibiotics: clarithromycin and azithromycin. Stott, GA, 1992) | 0.28 |
| " Azithromycin is stable at gastric pH and has an absolute bioavailability of approximately 37 percent following oral administration." | ( Azithromycin: the first azalide antibiotic. Amsden, GW; Ballow, CH, 1992) | 0.28 |
| "The absolute bioavailability of clarithromycin, a new macrolide antimicrobial agent, was assessed in a three-way, randomized, single-dose, crossover study conducted with 22 healthy volunteers, 19 of whom provided analyzable study data." | ( Absolute bioavailability of clarithromycin after oral administration in humans. Cavanaugh, J; Chu, SY; Deaton, R, 1992) | 0.28 |
| " It is concluded, that food does not affect the mean bioavailability of erythromycin acistrate neither the mean rate of absorption but in some subjects the absorption from enteric coated tablets might be significantly delayed." | ( Effect of food on absorption and hydrolysis of erythromycin acistrate. Haataja, H; Järvinen, A; Mattila, J; Nykänen, S, 1992) | 0.77 |
| " Its bioavailability from hard gelatin capsules containing the drug with or without sodium bicarbonate was studied in healthy volunteers." | ( Bioavailability of erythromycin acistrate from hard gelatin capsules containing sodium bicarbonate. Marvola, M; Nokelainen, M; Nykänen, S, 1991) | 0.61 |
| " More importantly, azithromycin has high tissue bioavailability and a tissue half-life of between 2 and 4 days." | ( Azithromycin in the treatment of uncomplicated genital chlamydial infections. Stamm, WE, 1991) | 0.28 |
| " The bioavailability of azithromycin is approximately 37% in humans (25% for erythromycin)." | ( The pharmacokinetics of azithromycin and their clinical significance. Lode, H, 1991) | 0.51 |
| " The purpose of this study is to investigate the possibility of a bioavailability parameter which relates the time that the drug concentration in the systemic circulation is maintained above a certain level (te) and the first time that the blood concentration exceeds this level (to)." | ( New bioavailability parameters to compare the efficacy of antimicrobial drugs in dosage forms. Ellis, SM; Koeleman, HA; Steyn, HS; Wessels, JC, 1991) | 0.28 |
| " The extent of absolute bioavailability of rectally administered erythromycin was increased from 28 per cent in neonates to 36 per cent in infants and to 54 per cent in children greater than 1 year." | ( Age dependence of erythromycin rectal bioavailability in children. Firsov, AA; Nazarov, AD; Petrachenkova, NA; Stratchunsky, LS, 1991) | 0.85 |
| " A series of in vitro equilibrium studies, taste screening, and bioavailability studies in dogs established the characteristics for the various drug-polymer ratios." | ( A polymer carrier system for taste masking of macrolide antibiotics. Borodkin, S; Diesner, C; Hernandez, L; Li, P; Lu, MY; Vadnere, M; Woodward, L, 1991) | 0.28 |
| "Analogs of 9-deoxo-12-deoxy-9,12-epoxyerythromycin A with an epimeric hydroxy, amino, or ketone substitution at the 11 position of the macrolide ring and an amino or epimeric hydroxy substitution at the 4" position of the cladinose sugar were synthesized in an attempt to produce acid-stable derivatives of erythromycin with improved bioavailability and activity against gram-negative bacteria." | ( In vitro activity and in vivo efficacy of a new series of 9-deoxo-12-deoxy-9,12-epoxyerythromycin A derivatives. Clement, JJ; Freiberg, LA; Hardy, DJ; Lartey, PA; Shipkowitz, NL; Swanson, RN, 1991) | 0.78 |
| " Hence EA has a good bioavailability essential for treatment and prophylaxis of bacterial infections in dentistry." | ( Penetration of erythromycin into periapical lesions after repeated doses of erythromycin acistrate and erythromycin stearate: a pilot study. Gordin, A; Kokkonen, P; Lehtinen, R; Peltola, J; Pohto, P; Tuominen, RK; Wikberg, R, 1991) | 0.63 |
| " Azithromycin had good oral bioavailability in rats and dogs (46% and 97%, respectively)." | ( Pharmacokinetics of azithromycin in rats and dogs. Falkner, FC; Shepard, RM, 1990) | 0.28 |
| "Tissue and plasma concentrations were determined after intravenous and oral administration of erythromycin to pigeons to establish the pharmacokinetics and bioavailability of the drug." | ( Pharmacokinetics and bioavailability of erythromycin in pigeons (Columba livia). De Backer, P; Devriese, LA; Remon, JP; Vanhaecke, E, 1990) | 0.77 |
| " We conclude that erythromycin can markedly increase the systemic bioavailability of bromocriptine, which can lead to increased therapeutic or adverse effects, whereas the effects of caffeine require further study." | ( Pharmacokinetic evaluation of erythromycin and caffeine administered with bromocriptine. Berchou, RC; Kareti, D; LeWitt, PA; Nelson, MV, 1990) | 0.9 |
| "64 micrograms/mL) are achieved by administration of the dose on an empty stomach 1 to 2 hours before or after meals; 3) corroborates other comparative studies reporting greater fasting bioavailability with this multiparticulate dosage form of erythromycin base than with reference single tablet or particle-in-tablet formulations; and 4) indicates that neutron activation of stable isotopes incorporated as a normal excipient in industrially-produced formulations provides an effective means for in vivo evaluation of dosage forms through gamma scintigraphy." | ( Gastrointestinal behavior of orally administered radiolabeled erythromycin pellets in man as determined by gamma scintigraphy. Beihn, R; Digenis, GA; Ghebre-Sellassie, I; Iyer, U; McClain, C; Nesbitt, RU; Parr, AF; Randinitis, E; Sandefer, EP; Scheinthal, BM, 1990) | 0.7 |
| " In addition, the data show that the bioavailability of TE-031 is slightly superior when the drug is administered on an empty stomach compared with after a meal." | ( [Basic and clinical studies on clarithromycin in pediatrics]. Iwai, N; Kasai, K; Miyazu, M; Nakamura, H; Taneda, Y, 1989) | 0.28 |
| " Bioavailability profiles obtained with MBA are consistent with reported data for erythromycin." | ( Microbioluminometry assay: determination of erythromycin activity in plasma or serum. Andreotti, PE; Hartmann, DM; Morse, IS, 1989) | 0.76 |
| " Several formulations are available, each with a different absorption rate and dosing profile." | ( Using erythromycin. Some helpful observations. Latare, PA; Setness, PA, 1989) | 0.76 |
| " The resultant decreased bioavailability of cyclosporine may precipitate graft rejection." | ( Interactions of cyclosporine with antimicrobial agents. Brown, RB; Sands, M, ) | 0.13 |
| "The effect of food on the relative bioavailability of an erythromycin particles-in-tablet formulation was studied in 27 healthy volunteers, using a four-way, crossover study design with the following treatments: one or two erythromycin capsules USP (Eryc, Parke-Davis), or one polymer-coated erythromycin particles-in-tablet (PCE, Abbott) administered fasting or with a high-fat meal." | ( Effect of a high-fat meal on the bioavailability of a polymer-coated erythromycin particle tablet formulation. Kinkel, AW; Randinitis, EJ; Sedman, AJ; Welling, PG, 1989) | 0.76 |
| " From these data it is apparent that intrapersonal variations in the absorption and disposition of erythromycin estolate are of a similar magnitude to interpersonal variations and should be borne in mind in the design and interpretation of comparative bioavailability studies involving similar formulations of this compound." | ( Variability in the absorption and disposition of erythromycin estolate in humans. Kanfer, I; Stubbs, C, 1989) | 0.75 |
| " The bioavailability of EA was slightly inferior to that of ES." | ( Efficacy of erythromycin acistrate (2'-acetyl erythromycin stearate) and erythromycin stearate in experimental infections in mice. Hanhijärvi, H; Havas, A; Komulainen, H; Männistö, PT; Rauramaa, V; Vuorela, A, 1989) | 0.66 |
| "Azithromycin (CP-62,993), a new acid-stable 15-membered-ring macrolide, was well absorbed following oral administration in mice, rats, dogs, and cynomolgus monkeys." | ( Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Cimochowski, CR; English, AR; Faiella, JA; Girard, AE; Girard, D; Gootz, TD; Haskell, SL; Retsema, JA, 1987) | 0.27 |
| " EPAC showed a better bioavailability than ES with longer-lasting serum levels of active antibiotic." | ( Human pharmacokinetics of erythromycin propionate-N-acetylcysteinate: comparative evaluation with erythromycin stearate and N-acetylcysteine. De Bernardi, M; Feletti, F; Fregnan, GB; Gazzani, G, 1988) | 0.58 |
| " We assessed the effect of simultaneous oral administration of NAC on the bioavailability of two antibiotics in ten healthy volunteers." | ( No effect of oral N-acetylcysteine on the bioavailability of erythromycin and bacampicillin. Borgström, L; Kågedal, B; Paulsen, O; Walder, M, 1988) | 0.52 |
| " Its absorption was slightly delayed but the bioavailability was good." | ( Fate of single oral doses of erythromycin acistrate, erythromycin stearate and pelleted erythromycin base analysed by mass-spectrometry in plasma of healthy human volunteers. Männistö, PT; Nykänen, S; Ottoila, P; Solkinen, A; Taskinen, J; Vuorela, A, 1988) | 0.57 |
| " In Study II, the effect of food on the bioavailability of the two EB preparations was studied after a single dose of 500 mg (2 x 250 mg enterocoated tablets) and after multiple dosing (2 x 250 mg tid)." | ( Absorption of erythromycin acistrate and erythromycin base in the fasting and non-fasting state. Männistö, PT; Pohto, P; Solkinen, A; Tuominen, RK; Vuorela, A, 1988) | 0.64 |
| " Evaluation of in vitro and in vivo antimicrobial activity indicated that derivatives of demycarosyltylosin (desmycosin) combined the broadest spectrum of antimicrobial activity with the best efficacy and bioavailability after oral administration." | ( Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. Counter, FT; Debono, M; Felty-Duckworth, AM; Kirst, HA; Ott, JL; Pekarek, RS; Toth, JE; Truedell, BA; Willard, KE, 1988) | 0.27 |
| " These pharmacokinetic changes are suggestive of an enhanced bioavailability of erythromycin in chronic renal failure which might predispose uremics to the ototoxicity of the drug." | ( Changes in erythromycin pharmacokinetics induced by renal failure. Fredj, G; Kanfer, A; Kenouch, S; Méry, JP; Stamatakis, G; Torlotin, JC, 1987) | 0.89 |
| "As a part of the quality control of drugs The National Medicine Control Laboratory in Finland has started comparative bioavailability studies of synonym preparations in human volunteers by taking all the products containing the same active ingredients for absorption studies at the same time." | ( The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. Konno, K; Palva, ES; Stenfors, E; Venho, VM, 1987) | 0.49 |
| " 3, there are no reasons to expect any difference in bioavailability after administration of two enteric-coated products, tablets and pellets in hard capsules." | ( Intra- and intersubject variation of erythromycin absorption from single-unit and multiple-unit enteric-coated products. Graffner, C; Josefsson, K; Stockman, O, ) | 0.4 |
| " Roxithromycin showed high blood levels and long half-lives of elimination in rodents after oral administration, and its bioavailability amounted to 72% in mice and 85% in rats, compared to less than 10% for erythromycin." | ( Antibacterial activity of roxithromycin: a laboratory evaluation. Bryskier, A; Chantot, JF; Gasc, JC, 1986) | 0.46 |
| " The increased dosage requirement could partly be explained by reduced bioavailability due to intestinal conversion of digoxin." | ( The significance of the enterohepatic circulation on the metabolism of digoxin in patients with the ability of intestinal conversion of the drug. Klitgaard, NA; Nørregaard-Hansen, K; Pedersen, KE, 1986) | 0.27 |
| " The lower bioavailability of the ethylsuccinate may be due to instability in the acidic medium of the stomach." | ( Bioinequivalence of erythromycin ethylsuccinate and enteric-coated erythromycin pellets following multiple oral doses. Feis, PJ; Rasmussen, CE; Wallen, S; Yakatan, GJ, ) | 0.45 |
| " Like tetracycline, erythromycin also appears to have the potential for increasing the bioavailability of digoxin in patients who excrete high amounts of reduced digoxin metabolites, apparently through destruction of the gut flora that form these compounds." | ( Pharmacokinetic interactions of the macrolide antibiotics. Ludden, TM, ) | 0.45 |
| "2 h), the extent of gastrointestinal absorption and bioavailability of erythromycin is apparently greater for the base pellets than for the stearate and ethylsuccinate formulations." | ( Relative bioavailability of enteric coated pellets, stearate and ethylsuccinate formulations of erythromycin. De Schepper, PJ; Josefsson, K; Mullie, A; Tjandramaga, TB; Van Hecken, A; Verbesselt, R; Verbist, L, 1984) | 0.72 |
| " The bioavailability of erythromycin stearate in tablet form and of erythromycin base in the form of enteric-coated pellets thus appears comparable when taken on an empty stomach." | ( Absorption of erythromycin stearate and enteric-coated erythromycin base after a single oral dose immediately before breakfast. Digranes, A; Schreiner, A, ) | 0.8 |
| "The clinical problem of testing for equivalence in comparative bioavailability trials is restated in terms of the proper statistical hypotheses." | ( A new statistical procedure for testing equivalence in two-group comparative bioavailability trials. Anderson, S; Hauck, WW, 1984) | 0.27 |
| "079 day-1), or absorption rate constant (14." | ( Effect of erythromycin on carbamazepine kinetics. Bell, RD; Ludden, TM; Wong, YY, 1983) | 0.67 |
| " Adequate absorption occurred with all treatments, although bioavailability was best when the drug was taken before food." | ( Influence of food on absorption of erythromycin ethyl succinate. Burgess, KR; Marlin, GE; Thompson, PJ, 1980) | 0.54 |
| " Criteria for the evaluation of erythromycin bioavailability studies include study design, patient population, meal composition and timing, and assay methodology." | ( Selection of an oral erythromycin product. Fraser, DG, 1980) | 0.86 |
| " In adult patients with BA (but not with CAO) theophylline plasma levels and bioavailability are higher after simultaneous erythromycin dosing." | ( Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: influence of erythromycin. Bah, H; Duroux, P; Giudicelli, JF; Mathieu, M; Richer, C; Thuillez, C, 1982) | 0.68 |
| " In four normal volunteers taking digoxin daily for four weeks, urinary excretion of DRPs was greatest after a poorly absorbed tablet was ingested, and least after intravenous administration, Stool cultures from subjects known to make DRPs in vivo ("excretors") converted digoxin to DRPs; cultures from nonexcretors did not." | ( Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. Butler, VP; Lindenbaum, J; Rund, DG; Saha, JR; Tse-Eng, D, 1981) | 0.26 |
| " In contrast, when a commercially available film-coated preparation of erythromycin base was evaluated in multidose fashion between meals (fasting), the drug was about 25% less well absorbed than commercially available enteric-coated base tablets." | ( Influence of study design in assessing food effects on absorption of erythromycin base and erythromycin stearate. Chodos, DJ; DiSanto, AR, 1981) | 0.73 |
| " Erythromycin ethylsuccinate and erythromycin stearate were equally well absorbed in the fasting state in subjects 6 months-6 years of age." | ( Absorption of erythromycin from pediatric suspension in infants and children. Blennow, M; Bolme, P; Eriksson, M, 1981) | 1.53 |
| " In this study, no difference was demonstrated in the apparent clearance rate (Clapp), apparent first-order absorption rate constant (ka), maximum serum drug concentration (Cmax), time of maximum drug concentration (Tmax) or absorption lag time (tlag) for theophylline before and after treatment with erythromycin." | ( The effects of erythromycin on the absorption and disposition of kinetics of theophylline. Branigan, TA; Cady, WJ; Nickols, JG; Robbins, RA; Ueda, CT, 1981) | 0.79 |
| "Correlations between the bioavailability parameters for erythromycin stearate tablets from five manufacturers and in vitro tests of these tablets were examined using forward (stepwise), multiple linear regression analysis." | ( Correlation of in vivo bioavailability of erythromycin stearate tablets with in vitro tests. Cabana, B; Dighe, S; Doluisio, JT; Loper, A; Martin, A; Martin, C; Stavchansky, S, 1980) | 0.77 |
| "The low and variable bioavailability of cyclosporine has been attributed to poor absorption." | ( Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Benet, LZ; Gomez, DY; Gupta, SK; Hebert, MF; Rowland, M; Wacher, VJ; Wu, CY, 1995) | 0.29 |
| " The absolute bioavailability of erythromycin from the capsule was 32 +/- 7% and for the duodenal solution 43 +/- 14%." | ( Evaluation of the intestinal absorption of erythromycin in man: absolute bioavailability and comparison with enteric coated erythromycin. Bochner, F; Hetzel, D; Somogyi, AA; Williams, DB, 1995) | 0.84 |
| " ABT-229 was > 300,000 times more potent than erythromycin in vitro and had 39% oral bioavailability in dog compared to its 4",12-dihydroxy congener (EM-523), which was only 400 times more potent than erythromycin and had relatively low (1." | ( Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate. Edwards, CM; Faghih, R; Freiberg, L; Klein, LL; Lartey, PA; Marsh, K; Nellans, HN; Petersen, A; Plattner, JJ; Quigley, S, 1995) | 0.55 |
| " The metabolic fate of temazepam and its almost complete bioavailability explain the lack of interaction." | ( Lack of interaction of erythromycin with temazepam. Luurila, H; Neuvonen, PJ; Olkkola, KT, 1994) | 0.6 |
| " First generation derivatives such as 2'-esters and acid-addition salts significantly improved the chemical stability and oral bioavailability of erythromycin." | ( Semi-synthetic derivatives of erythromycin. Kirst, HA, 1993) | 0.77 |
| " Dirithromycin may be taken without regard to meals, although food and H2-receptor antagonists may increase the systemic bioavailability in some patients." | ( Pharmacokinetics of dirithromycin. Black, HR; Busch, U; Cerimele, BJ; DeSante, KA; Sides, GD, 1993) | 0.29 |
| " The bioavailability and volume of distribution of prednisolone were unaffected by menopausal status." | ( The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics. Benet, LZ; Harris, RZ; Mroczkowski, P; Tsunoda, SM; Wong, H, 1996) | 0.52 |
| "This study was conducted to determine the effect of clarithromycin (CAM) on the bioavailability of cyclosporin (CYA) in rats, and to compare its effect with that of erythromycin (EM)." | ( Effect of clarithromycin on the bioavailability of cyclosporin in rats. Iwakawa, S; Komada, F; Ohba, M; Ohnishi, N; Okumura, K, 1996) | 0.49 |
| " Levofloxacin is a fluoroquinolone with excellent bioavailability properties that affords potential use in the treatment of a wide variety of infections caused by Gram-positive organisms such as streptococci." | ( The comparative antimicrobial activity of levofloxacin tested against 350 clinical isolates of streptococci. Biedenbach, DJ; Jones, RN, 1996) | 0.29 |
| " Clindamycin is an antimicrobial agent with excellent bioavailability after oral administration which has been considered for the therapy of community-acquired pneumococcal otitis media." | ( Clindamycin resistance among erythromycin-resistant Streptococcus pneumoniae. Cormican, MG; Jones, RN; Wanger, A, 1996) | 0.59 |
| "The oral bioavailability of buspirone is very low as a result of extensive first-pass metabolism." | ( Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole. Kantola, T; Kivistö, KT; Lamberg, TS; Neuvonen, PJ, 1997) | 0.54 |
| " After pre-administration of erythromycin the relative bioavailability of nifedipine after oral administration was increased compared with injection into the peritoneal cavity." | ( Inhibition of nifedipine metabolism in dogs by erythromycin: difference between the gut wall and the liver. Arimori, K; Nakamura, K; Nakano, M; Tsuruta, S, 1997) | 0.85 |
| " The rate of absorption of sertindole and the rate of appearance of dehydrosertindole in the systemic circulation after a 4-mg sertindole single dose were slightly enhanced by concomitant dosing of erythromycin." | ( The effect of erythromycin on the CYP3A component of sertindole clearance in healthy volunteers. Cao, G; Granneman, GR; Mack, RJ; Wong, SL, 1997) | 0.85 |
| " The influence of concomitant administration of erythromycin, a potent CYP3A4 inhibitor, on cerivastatin bioavailability and pharmacokinetics was investigated." | ( Influence of erythromycin pre- and co-treatment on single-dose pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin. Kuhlmann, J; Mück, W; Ochmann, K; Rohde, G; Unger, S, 1998) | 0.92 |
| " time and analysed for lag time, time to maximum concentration (tmax), maximum concentration (Cmax) and bioavailability (F)." | ( Which form of erythromycin should be used to treat gastroparesis? A pharmacokinetic analysis. Ehrenpreis, ED; Nellans, H; Zaitman, D, 1998) | 0.66 |
| "Lignocaine is metabolized by cytochrome P450 3A4 enzyme (CYP3A4), and has a moderate to high extraction ratio resulting in oral bioavailability of 30%." | ( Effect of erythromycin and itraconazole on the pharmacokinetics of oral lignocaine. Isohanni, MH; Neuvonen, PJ; Olkkola, KT, 1999) | 0.71 |
| " Systemic bioavailability of erythromycin base was low in all foals." | ( Comparison of microbiologic and high-performance liquid chromatography assays to determine plasma concentrations, pharmacokinetics, and bioavailability of erythromycin base in plasma of foals after intravenous or intragastric administration. Lakritz, J; Mihalyi, JE; Wilson, WD, 1999) | 0.79 |
| " Despite low systemic bioavailability of erythromycin base administered intragastrically, plasma concentrations of erythromycin exceeded, for at least 4 hours, the minimum inhibitory concentration of most Rhodococcus equi isolates." | ( Comparison of microbiologic and high-performance liquid chromatography assays to determine plasma concentrations, pharmacokinetics, and bioavailability of erythromycin base in plasma of foals after intravenous or intragastric administration. Lakritz, J; Mihalyi, JE; Wilson, WD, 1999) | 0.77 |
| " Bioavailability was higher in women (0." | ( Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans. Barnas, CR; Jones, MP; Krecic-Shepard, ME; Schwartz, JB; Slimko, J, 2000) | 0.31 |
| "Increased bioavailability of the P-glycoprotein (Pgp) substrates digoxin and cyclosporin due to erythromycin has been observed in vivo." | ( P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans. Gramatté, T; Kirch, W; Krappweis, J; Oertel, R; Schwarz, UI, 2000) | 0.83 |
| "We suggest that the increase in oral bioavailability of talinolol after concomitant erythromycin is caused by increased intestinal net absorption due to Pgp inhibition by erythromycin." | ( P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans. Gramatté, T; Kirch, W; Krappweis, J; Oertel, R; Schwarz, UI, 2000) | 0.83 |
| "To determine effects of prior feeding on pharmacokinetics and estimated bioavailability of orally administered microencapsulated erythromycin base (MEB) in healthy foals." | ( Effects of prior feeding on pharmacokinetics and estimated bioavailability after oral administration of a single dose of microencapsulated erythromycin base in healthy foals. Lakritz, J; Marsh, AE; Mihalyi, JE; Wilson, WD, 2000) | 0.71 |
| " Area under the plasma concentration-time curve, maximum plasma concentration, and estimated bioavailability were greater in foals when food was withheld than when foals were fed." | ( Effects of prior feeding on pharmacokinetics and estimated bioavailability after oral administration of a single dose of microencapsulated erythromycin base in healthy foals. Lakritz, J; Marsh, AE; Mihalyi, JE; Wilson, WD, 2000) | 0.51 |
| "These results indicate that the bioavailability of erythromycin was increased by the inhibitory effect of grapefruit juice on cytochrome P450 (CYP) 3A4-mediated metabolism in the small intestine." | ( The effects of grapefruit juice on the pharmacokinetics of erythromycin. Kanazawa, S; Ohkubo, T; Sugawara, K, ) | 0.63 |
| " The bioavailability of ABT-773 in humans is unaffected by food [383228] and in a phase I, randomized, double-blind trial in healthy males only mild adverse effects, usually affecting the gastrointestinal system, were observed [383208]." | ( ABT-773 (Abbott Laboratories). Lawrence, LE, 2001) | 0.31 |
| "P-glycoprotein (P-gp) is an efflux transporter involved in limiting the oral bioavailability and tissue penetration of a variety of structurally divergent molecules." | ( Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K, 2002) | 0.31 |
| " Sucralfate had no impact on the bioavailability of ABT-773." | ( ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate. Allewelt, M; Bulitta, J; Burkhardt, O; Lode, H; Pletz, MW; Preechachatchaval, V, 2003) | 0.32 |
| " High performance liquid chromatography and IBM/XT microcomputer was used to determine the bioavailability and pharmacokinetic parameters in vivo." | ( Bioavailability and stability of erythromycin delayed release tablets. Ogwal, S; Xide, TU, 2001) | 0.59 |
| " The relative bioavailability of erythromycin delayed release tablet to erythromycin capsules was 105." | ( Bioavailability and stability of erythromycin delayed release tablets. Ogwal, S; Xide, TU, 2001) | 0.87 |
| "The content, appearance, and dissolution bioavailability of delayed release erythromycin tablets conforms to the United States pharmacopoeia standards." | ( Bioavailability and stability of erythromycin delayed release tablets. Ogwal, S; Xide, TU, 2001) | 0.82 |
| "Consumption of typical quantities of grapefruit juice (GFJ) increases the oral bioavailability of several CYP3A4 substrates without affecting their elimination, consistent with selective inhibition of intestinal but not hepatic CYP3A4." | ( Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice. Burke, JP; Dorval, EP; Gillen, LP; Greenberg, HE; Hauck, WW; Pequignot, E; Veronese, ML; Waldman, SA, 2003) | 0.32 |
| " These experiments have allowed a more complete characterization of ketoconazole as a prototypic dual Pgp/CYP3A inhibitor and its use as a tool in a preclinical setting and further demonstrate the use of the monkey to investigate the role of Pgp/CYP3A in limiting the oral bioavailability of new drug candidates." | ( Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey. Azzarano, LM; Kehler, JR; McSurdy-Freed, JE; Morgan, JA; Proksch, JW; Smith, BR; Stelman, GJ; Ward, KW; Zeigler, KS, 2004) | 0.32 |
| " Therefore, ocular bioavailability of P-gp substrates can be significantly enhanced by proper selection of P-gp inhibitors." | ( Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption. Dey, S; Gunda, S; Mitra, AK, 2004) | 0.65 |
| " The ratio of the in vivo dissolution rate, the in vivo decomposition rate and the absorption rate between CAM and EMS were well correlated to the ratio of the in vitro intrinsic dissolution rate, the decomposition rate in the acidic solution, and partition coefficient, respectively." | ( Comparative study of pharmacokinetic parameters between clarithromycin and erythromycin stearate in relation to their physicochemical properties. Ishii, K; Itai, S; Nagai, T; Nemoto, M; Saito, Y; Takayama, K, 1998) | 0.53 |
| "Biotransformation in the intestine may influence the bioavailability and toxicity of ingested xenobiotics." | ( Properties and regional expression of a CYP3A-like protein in channel catfish intestine. Celander, MC; James, MO; Lou, Z; Rowland-Faux, L, 2005) | 0.33 |
| " These results indicate that the mechanism of the pharmacokinetic interaction between oral ximelagatran and erythromycin may involve inhibition of transport proteins, possibly P-gp, resulting in decreased melagatran biliary excretion and increased bioavailability of melagatran." | ( Influence of erythromycin on the pharmacokinetics of ximelagatran may involve inhibition of P-glycoprotein-mediated excretion. Dorani, H; Eriksson, UG; Fritsch, H; Hoffmann, KJ; Karlsson, J; Olsson, L; Sarich, TC; Schützer, KM; Wall, U, 2006) | 0.92 |
| " Low ocular bioavailability of drugs has been attributed primarily to low permeability across corneal epithelium, thus leading to sub-therapeutic concentrations of drug in the eye and treatment failure." | ( Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux. Karla, PK; Mitra, AK; Pal, D; Quinn, T, 2007) | 0.34 |
| " Human oral bioavailability is an important pharmacokinetic property, which is directly related to the amount of drug available in the systemic circulation to exert pharmacological and therapeutic effects." | ( Hologram QSAR model for the prediction of human oral bioavailability. Andricopulo, AD; Moda, TL; Montanari, CA, 2007) | 0.34 |
| " These compounds show moderate to high clearance and low oral bioavailability in preliminary in vivo pharmacokinetic studies in rat." | ( Synthesis and biological properties of 4''-O-acyl derivatives of 8a-Aza-8a-homoerythromycin. Alihodzic, S; Erakovic Haber, V; Fajdetic, A; Istuk, ZM; Lazarevski, G; Marsic, N; Mutak, S; Padovan, J; Palej, I; Paljetak, HC; Stimac, V; Tavcar, B, 2009) | 0.58 |
| "The macrolide antibiotics azithromycin and clarithromycin are large molecular weight compounds that exhibit moderate to excellent oral bioavailability in preclinical species and humans." | ( Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides. Davis, CB; Dawson, PA; Garver, E; Han, C; Haywood, J; Lan, T; Rao, A, 2009) | 0.35 |
| "Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh)." | ( Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV, 2010) | 0.36 |
| " With oral dosing, the bioavailability of ER increased 36% in patients with ESRD, and this increase was not related to changes in gut availability." | ( Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Benet, LZ; Frassetto, LA; Huang, Y; Sun, H, 2010) | 0.62 |
| " Such clarification may lead to the development of strategies to overcome efflux and enhance its bioavailability at target site." | ( Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance. Kwatra, D; Mitra, AK; Pal, D; Vadlapatla, RK; Vadlapudi, AD, 2010) | 0.36 |
| "The aim of this work was to enhance the bioavailability of erythromycin base when administered orally in rainbow trout (Oncorhynchus mykiss)." | ( Development and pharmacokinetic evaluation of erythromycin lipidic formulations for oral administration in rainbow trout (Oncorhynchus mykiss). Ballestrazzi, R; Coni, E; Grabnar, I; Hasa, D; Pellegrini, E; Perissutti, B; Serdoz, F; Voinovich, D, 2011) | 0.87 |
| " This substrate specificity of gemifloxacin towards these efflux transporters may be one of the major factors accounting for low oral bioavailability (71%)." | ( Differential effect of P-gp and MRP2 on cellular translocation of gemifloxacin. Kwatra, D; Mitra, AK; Pal, D; Vadlapatla, RK; Vadlapudi, AD, 2011) | 0.37 |
| "The aim of this study was to compare the roles of gastrointestinal absorption and hepatic extraction as barriers to oral bioavailability for macrolide antibiotics erythromycin, clarithromycin, roxithromycin and telithromycin." | ( Investigating the barriers to bioavailability of macrolide antibiotics in the rat. Bencetić Mihaljević, V; Letfus, V; Milić, A; Padovan, J; Ralić, J, 2012) | 0.57 |
| " These compounds exhibited marked advances over azithromycin in vitro in terms of potency against Plasmodium falciparum (over 100-fold) and high selectivity for the parasite and were characterized by moderate oral bioavailability in vivo." | ( Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin. Ager, A; Alihodžić, S; Bukvić Krajačić, M; Ellis, WY; Fajdetić, A; Hutinec, A; Ivezić-Schönfeld, Z; Jelić, D; Landek, G; Mesić, M; Milhous, WK; Ohrt, C; Padovan, J; Perić, M; Rupčić, R; Smith, KS; Spaventi, R; Ziher, D, 2012) | 0.38 |
| " The novel topical application has many advantages like averting the GI-irritation, preventing the metabolism of drugs in the liver and increasing the bioavailability of the drug over the conventional dosage forms." | ( Topical Delivery of Erythromycin Through Cubosomes for Acne. Bhargava, S; Jain, A; Jain, P; Jain, R; Jain, S; Khan, S, 2018) | 0.8 |
| " The purpose of the present study was to assess the bioavailability of sulfamethazine, erythromycin, or ciprofloxacin through aqueous extractions with borax or EDTA solutions and their biodegradation following different soil exposure scenarios." | ( Explaining the accelerated degradation of ciprofloxacin, sulfamethazine, and erythromycin in different soil exposure scenarios by their aqueous extractability. Asghar, F; Benoit, P; Goulas, A; Haudin, CS; Sabourin, L; Topp, E, 2018) | 0.93 |
| " In vivo and in vitro studies were performed to assess absolute bioavailability of finerenone, the effect of metabolic enzyme inhibitors on the pharmacokinetics of finerenone and its metabolites, the quantitative contribution of the involved enzymes cytochrome P450 (CYP) 3A4 and CYP2C8 and the relevance of gut wall versus liver metabolism." | ( Pharmacokinetics of the Novel, Selective, Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in Healthy Volunteers: Results from an Absolute Bioavailability Study and Drug-Drug Interaction Studies In Vitro and In Vivo. Engelen, A; Gerisch, M; Heinig, R; Loewen, S; Nagelschmitz, J, 2018) | 0.48 |
| " Absolute bioavailability was assessed in volunteers receiving finerenone orally and by intravenous infusion (n = 15) and the effects of erythromycin (n = 15), verapamil (n = 13) and gemfibrozil (n = 16) on finerenone pharmacokinetics were investigated." | ( Pharmacokinetics of the Novel, Selective, Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in Healthy Volunteers: Results from an Absolute Bioavailability Study and Drug-Drug Interaction Studies In Vitro and In Vivo. Engelen, A; Gerisch, M; Heinig, R; Loewen, S; Nagelschmitz, J, 2018) | 0.68 |
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
The newer macrolide antibiotics offer the advantage of fewer adverse gastrointestinal effects than erythromycin and dosing regimens of only once or twice a day. For those patients with theophylline levels at the higher end of the therapeutic range (15 to 20 micrograms/ml), we recommend an initial 25% reduction in theophyLLine dosage when erythyromycin is added.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2 ON ERYTHROMYCIN STEARATE AND COMMERCIAL DOSAGE FORMS OF ERYTHROMYCIN STEARATE WAS STUDIED." | ( Gastric acid inactivation of erythromycin stearate in solid dosage forms. Boggiano, BG; Gleeson, M, 1976) | 1.06 |
| "The penetration of oral erythromycin stearate (Abboticin), administered in a dosage of 500 mg three times a day, into the maxillary sinus mucosa and secretion was studied in 15 patients (22 sinuses) operated on for chronic maxillary sinusitis." | ( Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis. Kohonen, A; Paavolainen, M; Palva, T; Renkonen, OV, ) | 0.79 |
| " Erythromycin in a dosage of 40--50 mg/kg/day was significantly more effective than amoxycillin in a dosage of 25--30 mg/kg/day." | ( Effect of erythromycin and amoxycillin on Bordetella pertussis in the nasopharynx. Trollfors, B, 1978) | 1.57 |
| "5 hr after dosing there is twice as much desmethyl-PE in plasma as PE." | ( Metabolism of propionyl erythromycin lauryl sulfate. I. Fate of the propionyl erythromycin moiety in the rat. Marshall, FJ; McMahon, RE; Murphy, PJ; Williams, TL, ) | 0.44 |
| " A new general equation relating the response of the test organism to concentrations of active materials was used to account for factors in addition to the antibiotic upon the dose-response line." | ( Automated system for analytical microbiology V: calibration lines for antibiotics. Kavanagh, F, 1975) | 0.25 |
| " Up to this time, amoxicillin has not been commercially available as an injectable dosage form." | ( Pneumococcal meningitis-therapeutic studies in mice. Hirth, RS; Price, KE; Tsai, YH; Williams, EB, 1975) | 0.25 |
| " Strains of Clostridium tetani inoculated into these sera failed to multiply when the donor had taken 500 mg of erythromycin estolate before a meal; other erythromycin preparations and the estolate at a dosage of 250 mg were ineffective or inconsistent in their inhibition of the growth of Cl." | ( Prophylaxis against tetanus in non-immune patients with wounds: the role of antibiotics and of human antitetanus globulin. Jackson, DM; Kidson, A; Lilly, HA; Lowbury, EJ; Wilkins, MD, 1978) | 0.47 |
| " Lower serum levels of antibiotics in pregnant women than in other individuals following the same dosage will be unsatisfactory as micr-organisms are less likely to be affected." | ( Pharmacokinetics of antibiotics in pregnancy and labour. Philipson, A, ) | 0.13 |
| "The recommended dosage of erythromycin, without regard to the formulation prescribed, for children with streptococcal pharyngitis is 30 to 40 mg/kg/day." | ( Streptococcal pharyngitis therapy. A comparison of two erythromycin formulations. Derrick, CW; Dillon, HC, 1979) | 0.81 |
| " Absorption of all dosage forms, except the suspension, was delayed, and pharmacokinetic interpretation of both single- and multiple-dose data required incorporation of an absorption lag time." | ( Plasma levels following single and repeated doses of erythromycin estolate and erythromycin stearate. Corrick-West, HP; Elliott, RL; Lyons, LL; Pitterle, ME; Welling, PG, 1979) | 0.51 |
| "A novel computerized automated system is described which conforms to the basic requirements set forth in the compendia for testing the dissolution characteristics of solid dosage forms." | ( ADS-12: an automated programmable 12-tablet dissolution testing system. Bendrot, H; Cioffi, FJ; Martynovych, S, 1979) | 0.26 |
| "The influence of various test meals and coadministered water volumes on erythromycin stearate bioavailability from orally dosed film-coated tablets was studied in healthy human subjects." | ( Bioavailability of erythromycin stearate: influence of food and fluid volume. Hewitt, PF; Huang, H; Lyons, LL; Welling, PG, 1978) | 0.82 |
| "Streptococcal eradication rates of 86% were demonstrated in 97 patients seen on day 14 and in 73 patients seen on both days 14 and 28 after a ten-day course of erythromycin estolate therapy given at a dosage of 20 mg/kg/day, administered in two equal doses." | ( Erythromycin therapy for streptococcal pharyngitis. Derrick, CW; Dillon, HC, 1976) | 1.89 |
| " Marine Corps recruit volunteers received one of the two antibiotics in a dosage of 2 g daily for 7 days." | ( Comparison of josamycin and erythromycin in the therapy of Mycoplasma pneumoniae pneumonia. Dodd, WK; Gwaltney, JM; Hendley, JO; Wenzel, RP, 1976) | 0.55 |
| "Serum erythromycin concentration data from several repetitive dosing studies were analyzed with newly developed computer methods for fitting multiple-dose data and generating nonlinear least-squares estimates of pharmacokinetic parameters." | ( Pharmacokinetics of erythromycin on repetitive dosing. Colburn, WA; Di Santo, AR; Gibaldi, M, 1977) | 1.06 |
| " Except for benzathine penicillin, the efficacy of the currently recommended dosage schedules are documented only by Schroeter et al." | ( Treatment of primary syphilis. Elliott, WC, 1976) | 0.26 |
| " Bacillus subtilis is used as test germ for dosage of ampicillin and Sarcina lutea for the dosage of erythromycin." | ( [Passage into normal salivary, lacrimal and nasal secretions of ampicillin and erythromycin administered intramuscularly]. Melon, J; Reginster, M, 1976) | 0.7 |
| " This single dose study provides information which is essential for the design of a satisfactory dosage regimen." | ( Pharmacokinetic interpretation of erythromycin and tylosin activity in serum after intravenous administration of a single dose to cows. Baggot, JD; Gingerich, DA, 1976) | 0.53 |
| " The model is offered as a useful approach to predict dosage adjustment in uremic patients with drugs for which data are not available." | ( Prediction of drug dosage in patients with renal failure using data derived from normal subjects. Craig, WA; Kunin, CM; Welling, PG, 1975) | 0.25 |
| "The chemistry, mechanism of action, antimicrobial spectrum, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, and dosage and administration of clarithromycin and azithromycin are described." | ( Clarithromycin and azithromycin: new macrolide antibiotics. Danziger, LH; Piscitelli, SC; Rodvold, KA, 1992) | 0.28 |
| " Trials were assessed by sample size, macrolide dosage regimen, and therapeutic response." | ( The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin. Bahal, N; Nahata, MC, 1992) | 0.28 |
| " The high tissue-to-serum level and extended elimination half-life of azithromycin allow for once-daily dosing and short-course therapy." | ( The new macrolide antibiotics. Azithromycin and clarithromycin. Havlichek, DH; Stein, GE, 1992) | 0.28 |
| " These properties allow novel dosing schemes for azithromycin, because a five-day course will provide therapeutic tissue concentrations for at least ten days." | ( Azithromycin and clarithromycin: overview and comparison with erythromycin. Tunkel, AR; Whitman, MS, 1992) | 0.52 |
| " Blood samples were drawn for AZM measurement over 72 and 360 h on the first and fifth AZM administrations, respectively, as well as before and 3 h after dosing on the second, third, and fourth AZM dosings." | ( Once-a-week azithromycin in AIDS patients: tolerability, kinetics, and effects on zidovudine disposition. Biollaz, J; Chatton, JY; Chave, JP; Dayer, P; Glauser, MP; Munafo, A, 1992) | 0.28 |
| " Oral drug administration was initiated 4 h after infection by various dosage regimens." | ( Activity and local delivery of azithromycin in a mouse model of Haemophilus influenzae lung infection. Azoulay-Dupuis, E; Bergogne-Bérézin, E; Pocidalo, JJ; Vallée, E, 1992) | 0.28 |
| " However, the prolonged half-life and enhanced tissue penetration of azithromycin should allow for less frequent dosing and shorter duration of therapy than with erythromycin or clarithromycin." | ( In vitro activities of azithromycin, clarithromycin, L-ofloxacin, and other antibiotics against Chlamydia pneumoniae. Hammerschlag, MR; Qumei, KK; Roblin, PM, 1992) | 0.48 |
| "To discuss the chemistry, mechanism of action, spectrum of activity, pharmacokinetics, clinical trials, adverse-effect profile, drug interactions, and dosage guidelines of azithromycin, the first azalide antibiotic." | ( Azithromycin: the first azalide antibiotic. Amsden, GW; Ballow, CH, 1992) | 0.28 |
| " Azithromycin possesses key pharmacokinetic properties that are prerequisites for a convenient once-daily dosage schedule which may improve patient compliance." | ( Azithromycin pharmacokinetics and penetration to lymph. Bergan, T; Jørgensen, NP; Olszewski, W; Zhang, Y, 1992) | 0.28 |
| " In comparison to other new macrolides, azithromycin achieves higher tissue and intracellular concentrations and these concentrations are sustained for several days after dosing due to a long elimination half-life." | ( Azithromycin in lower respiratory tract infections. Lode, H; Schaberg, T, 1992) | 0.28 |
| " Although azithromycin has been shown to be effective in the treatment of erythema migrans, further studies will be needed to determine the optimal dosage and duration of therapy." | ( Erythema migrans: comparison of treatment with azithromycin, doxycycline and phenoxymethylpenicillin. Cimperman, J; Ruzic, E; Strle, F, 1992) | 0.28 |
| " or once daily dosage regimens, good intracellular and tissue penetration, better activity against gram-negative microorganisms (some) and a low rate of adverse reactions." | ( Clinical use of the new macrolides, azalides, and streptogramins in pediatrics. Adam, D, 1992) | 0.28 |
| " Metabolite peak concentration and area under the plasma concentration-time curve data after oral dosing were generally greater than those after intravenous infusion, suggesting that marked first-pass metabolism of clarithromycin occurs after oral administration." | ( Absolute bioavailability of clarithromycin after oral administration in humans. Cavanaugh, J; Chu, SY; Deaton, R, 1992) | 0.28 |
| " The dosage of EM was 200-1200 mg/day." | ( [Long-term chemotherapy using erythromycin (EM) for chronic lower airway infection: effectiveness of clarithromycin in EM ineffective cases--the fourth report]. Hamada, K; Kita, E; Konishi, M; Kunimatsu, M; Maeda, K; Masutani, T; Mikasa, K; Sano, R; Sawaki, M; Takeuchi, S, 1992) | 0.57 |
| " To determine whether heterogeneity in P450IIIA activity contributes to interpatient differences in cyclosporine dosing requirements, the oral pharmacokinetics of the drug were determined in 20 stable kidney transplant recipients." | ( Erythromycin breath test predicts oral clearance of cyclosporine in kidney transplant recipients. Annesley, TM; Leichtman, AB; Normolle, DP; Smith, DE; Turgeon, DK; Watkins, PB, 1992) | 1.73 |
| " PCE Dispertab, a more expensive brand of erythromycin, has been promoted as a well-tolerated new dosage form; however, no studies compare its GI side effects with those of other forms of erythromycin." | ( A comparison of the gastrointestinal side effects of two forms of erythromycin. Anastasio, GD; Leitch, BB; Little, JM; Norton, HJ; Pettice, YL; Robinson, MD, 1992) | 0.78 |
| " Both these antimicrobials seem appropriate for the treatment of meningitis caused by penicillin G-resistant pneumococci provided their dosage is adjusted to achieve adequate drug levels in the cerebrospinal fluid." | ( [Bacteriostatic activity and killing curves of eight antibiotics against seven strains of penicillin G-resistant pneumococci]. Barakett, V; Burghoffer, B; Delisle, F; Guidet, B; Lesage, D; Offenstadt, G; Petit, JC; Richard, G; Vergez, P, 1992) | 0.28 |
| " Food intake immediately before dosing increased the extent of absorption from the 500-mg tablet formulation by approximately 25%." | ( Drug-food interaction potential of clarithromycin, a new macrolide antimicrobial. Cavanaugh, JC; Chu, S; Locke, C; Park, Y; Wilson, DS, 1992) | 0.28 |
| "6 micrograms/ml after oral dosing with 250 and 500 mg in the same subjects." | ( Macrolide pharmacokinetics and dose scheduling of roxithromycin. Aamo, T; Nilsen, OG; Svarva, P; Zahlsen, K, ) | 0.13 |
| " Successful antibiotic treatment with tetracycline or erythromycin requires high dosage and a prolonged course." | ( Chlamydia pneumoniae, strain TWAR pneumonia. Grayston, JT, 1992) | 0.53 |
| ", increased resistance to penicillin and erythromycin and inconvenient dosing schedules) have led to an adjustment in the kinds of antimicrobial agents prescribed for these diseases." | ( Clinical trials of cefprozil for treatment of skin and skin-structure infections: review. Nolen, TM, 1992) | 0.55 |
| " Administration of erythromycin to asthmatic patients in a dosage of 600 mg/d for 10 weeks reduced the bronchial hyperresponsiveness measured by histamine inhalation test." | ( Effect of erythromycin on bronchial hyperresponsiveness in patients with bronchial asthma. Miyatake, H; Satake, T; Suzuki, K; Takagi, K; Taki, F, 1991) | 1.01 |
| " These pharmacokinetic properties imply that the dosing period for azithromycin can be greatly reduced while still achieving high antimicrobial activity at sites of infection." | ( Azithromycin in the treatment of uncomplicated genital chlamydial infections. Stamm, WE, 1991) | 0.28 |
| " Erythromycin's short half-life means that a four-times daily dosage schedule is required for effective treatment." | ( The pharmacokinetics of azithromycin and their clinical significance. Lode, H, 1991) | 1.19 |
| " Clarithromycin is better tolerated than erythromycin and its twice daily dosage is likely to lead to better patient compliance." | ( Clarithromycin in the treatment of community-acquired lower respiratory tract infections. Anderson, G, 1991) | 0.55 |
| " There was no significant relationship between the dosage of clarithromycin and the incidence of adverse events." | ( The tolerance and toxicity of clarithromycin. Wood, MJ, 1991) | 0.28 |
| "Pharmacokinetic parameters such as AUC, Cmax and tmax have been used to represent the rate and extent of absorption of drugs from dosage forms in comparative bioequivalence testing." | ( New bioavailability parameters to compare the efficacy of antimicrobial drugs in dosage forms. Ellis, SM; Koeleman, HA; Steyn, HS; Wessels, JC, 1991) | 0.28 |
| " At a dosage of 25 mg/kg, minocycline was more active than clarithromycin at a dosage of 50 mg/kg." | ( Effectiveness of clarithromycin and minocycline alone and in combination against experimental Mycobacterium leprae infection in mice. Grosset, JH; Ji, B; Perani, EG, 1991) | 0.28 |
| " The macrolide was administered at the oral dosage of 250 mg twice daily for a period ranging from 7 to 11 days, only after microbiological evaluation of sputum." | ( Clarithromycin in the treatment of bacterial relapses of chronic bronchitis. Bianco, A; Cuccurullo, S; Dericoloso, A; Moro, RA; Sanduzzi, A; Sarno, M, ) | 0.13 |
| " Since anhydroerythromycin appears to be a more potent inhibitor of androstenedione 6 beta-hydroxylation than erythromycin, we speculate that the variable blood levels of anhydroerythromycin found after dosing with erythromycin may explain these discrepancies." | ( The inhibition of drug oxidation by anhydroerythromycin, an acid degradation product of erythromycin. Sansom, LN; Stupans, I, 1991) | 0.9 |
| " In this study, mean daily dosage was 40-50 mg/kg for cefaclor and 50 mg/kg ES + 150 mg/kg sulfamide for Pediazole." | ( [An open randomized trial, Pediazole versus cefaclor in the treatment of acute otitis media in children]. Bedbeder, P; Boucherat, M; Bouhanna, CA; Cohen, R; de La Rocque, F; Geslin, P; Peynegre, R; Reinert, P, 1991) | 0.28 |
| " Treatment with clarithromycin at half the dosage of josamycin was found to have comparable efficacy and to be associated with a lower incidence of adverse events." | ( Efficacy and safety of clarithromycin versus josamycin in the treatment of hospitalized patients with bacterial pneumonia. Scarpazza, G; Straneo, G, ) | 0.13 |
| " Dosage of clarithromycin and erythromycin was 250 mg twice daily and 500 mg twice daily, respectively; each patient was given a 10-day supply of medication." | ( Comparison of the clinical and bacteriological efficacy of clarithromycin and erythromycin in the treatment of streptococcal pharyngitis. Scaglione, F, 1990) | 0.8 |
| " Tissue concentrations were higher after multiple dosing and became greater as the dose was increased from 10 to 40 mg/kg." | ( Pharmacokinetics of azithromycin in rats and dogs. Falkner, FC; Shepard, RM, 1990) | 0.28 |
| " The high tissue concentrations suggest that proposed standard dosage regimens of 500 mg qds on day 1 followed by 250 mg qds for four days, or three daily dosages of 500 mg, will produce tissue concentrations above 3 mg/kg in a variety of tissues." | ( The pharmacokinetics of azithromycin in human serum and tissues. Foulds, G; Johnson, RB; Shepard, RM, 1990) | 0.28 |
| " Dosing with azithromycin eradicated Haemophilus influenzae from the bulla (middle ear) of gerbils, as was not the case with erythromycin and roxithromycin." | ( Relationship of high tissue concentrations of azithromycin to bactericidal activity and efficacy in vivo. Girard, AE; Girard, D; Milisen, WB; Retsema, JA, 1990) | 0.49 |
| " Doxycycline, comparable in cost to tetracycline and with a less frequent dosage schedule, is the drug of first choice." | ( Treatment of Chlamydia trachomatis genital infection. Barnes, RC; Toomey, KE, ) | 0.13 |
| " The overall incidence of gastrointestinal side effects (abdominal pain and cramps, nausea, vomiting, diarrhea, and gas) of two common erythromycin base formulations, Erythromycin Base Filmtab (Abbott), a nonenteric-coated base tablet, and Eryc (Parke-Davis), a pelletized, encapsulated, enteric-coated base capsule, were compared in 368 adults at two dosage levels (1 g/d and 2 g/d)." | ( Prospective comparison of patient tolerance to enteric-coated vs nonenteric-coated erythromycin. Christensen, DB; Ellsworth, AJ; Volpone-McMahon, MT, 1990) | 0.71 |
| " The addition of dirithromycin (500 mg orally once daily at 7:00 AM) to a sustained-release theophylline dosing regimen (200 mg every 12 hours) elicited small changes in the steady-state pharmacokinetics of theophylline." | ( Changes in the steady-state pharmacokinetics of theophylline during treatment with dirithromycin. Bachmann, K; DeSante, K; Jauregui, L; Martin, M; Nunlee, M; Sides, GD; Sullivan, T, 1990) | 0.28 |
| " Seventy-three children with impetigo were randomly assigned to receive penicillin V potassium or cephalexin monohydrate, both administered in dosages of 40 to 50 mg/kg per day, or erythromycin estolate administered in a dosage of 30 to 40 mg/kg per day." | ( Impetigo. Current etiology and comparison of penicillin, erythromycin, and cephalexin therapies. Bass, JW; Browning, WC; Demidovich, CW; Ruff, ME; Wittler, RR, 1990) | 0.72 |
| " The mean elimination half-life was significantly longer in the elderly group only after multiple dosing (4." | ( Effect of age on single- and multiple-dose pharmacokinetics of erythromycin. Miglioli, PA; Okolicsanyi, L; Orlando, R; Palatini, P; Pivetta, P; Strazzabosco, M, 1990) | 0.52 |
| " The relative bioavailability after direct crop administration of erythromycin thiocyanate or erythromycin ethylsuccinate at a dosage rate of 100 mg/kg was less than 10%." | ( Pharmacokinetics and bioavailability of erythromycin in pigeons (Columba livia). De Backer, P; Devriese, LA; Remon, JP; Vanhaecke, E, 1990) | 0.78 |
| " Neutron activation thus appears to simplify the radiolabeling of complex pharmaceutical dosage forms for in vivo study by external gamma scintigraphy." | ( Manufacture and properties of erythromycin beads containing neutron-activated erbium-171. Digenis, GA; Ghebre-Sellassie, I; Iyer, U; Nesbitt, RU; Parr, AF; Sandefer, EP; Scheinthal, BM, 1990) | 0.57 |
| " Therefore, the patients were given prednisone at an initial dosage of 50-100 mg which was subsequently reduced." | ( [Persisting alveolitis after Legionella pneumonia]. Hürter, T; Lorenz, J; Rumpelt, HJ; Schlegel, J, 1990) | 0.28 |
| "64 micrograms/mL) are achieved by administration of the dose on an empty stomach 1 to 2 hours before or after meals; 3) corroborates other comparative studies reporting greater fasting bioavailability with this multiparticulate dosage form of erythromycin base than with reference single tablet or particle-in-tablet formulations; and 4) indicates that neutron activation of stable isotopes incorporated as a normal excipient in industrially-produced formulations provides an effective means for in vivo evaluation of dosage forms through gamma scintigraphy." | ( Gastrointestinal behavior of orally administered radiolabeled erythromycin pellets in man as determined by gamma scintigraphy. Beihn, R; Digenis, GA; Ghebre-Sellassie, I; Iyer, U; McClain, C; Nesbitt, RU; Parr, AF; Randinitis, E; Sandefer, EP; Scheinthal, BM, 1990) | 0.7 |
| " TE-031 granules were orally administered to 5 children in a dosage of 5 mg/kg before meal." | ( [Basic and clinical studies on use of clarithromycin granules in pediatrics]. Hayashi, M; Kida, K; Matsuda, H; Murase, M, 1989) | 0.28 |
| " TE-031 was administered at a daily dosage of 400 mg in 2 divided doses, and JM was given at a daily dosage of 1,200 mg in 3 divided doses." | ( [Clinical evaluation of clarithromycin in treatment of acute dental infections. Comparative double-blind study using josamycin as the control]. Ikeshima, K; Morihana, T; Morishima, T; Noma, H; Sakamoto, H; Sasaki, J; Shiiki, K; Takai, H; Tomita, F; Uematsu, M, 1989) | 0.28 |
| " influenzae with the drug dosage used in this study." | ( Azithromycin (CP-62,993) in acute exacerbations of chronic bronchitis: an open clinical, microbiological and pharmacokinetic study. Davies, BI; Gubbelmans, R; Maesen, FP, 1989) | 0.28 |
| " Azithromycin was more potent than the other macrolides in experimental animal infection, eradicating the organism in all animals tested at a dosage of 8 mg/kg." | ( Comparative antimicrobial activity of the new macrolides against Borrelia burgdorferi. Gross, B; Preac-Mursic, V; Schierz, G; Süss, E; Wilske, B, 1989) | 0.28 |
| " Several formulations are available, each with a different absorption rate and dosing profile." | ( Using erythromycin. Some helpful observations. Latare, PA; Setness, PA, 1989) | 0.76 |
| " Thus the previous recommendation of decreasing the theophylline dosage by 25% to prevent toxicity during erythromycin therapy is irrational and should be avoided." | ( Theophylline toxicity due to drug interaction. Tenenbein, M, ) | 0.34 |
| " The dose-response curve of the EMA was parallel to that of motilin and the effects of motilin and EMA were additive." | ( Erythromycin is a motilin receptor agonist. Cachet, T; Depoortere, I; Hoogmartens, J; Matthijs, G; Peeters, T; Vantrappen, G, 1989) | 1.72 |
| "5 +/- 13 min for the 15 mg/kg dosage to 239 +/- 10." | ( A comparison of the various routes of administration of erythromycin in cattle. Burrows, GE; Griffin, DD; Harris, K; Pippin, A, 1989) | 0.52 |
| "Two hundred sixty-five adult and adolescent patients with possible streptococcal pharyngitis were treated with either erythromycin ethylsuccinate or an enteric-coated erythromycin in a twice-daily dosage schedule." | ( Erythromycin in acute pharyngitis: a comparison of efficacy and patient tolerance of two twice-daily preparations. Guthrie, R, 1988) | 1.93 |
| " Adequate dosage and length of treatment might be crucial for these results." | ( Erythromycin in the treatment of pertussis: a study of bacteriologic and clinical effects. Bergquist, SO; Bernander, S; Dahnsjö, H; Sundelöf, B, 1987) | 1.72 |
| " Practical means of avoiding this risk consists in limiting such drug combinations, reducing benzodiazepine dosage and, if a combined treatment is necessary, using by preference either benzodiazepines degraded by conjugation instead of oxidation, or macrolides, or anti-H2 compounds with reduced inhibitory effect on microsomes." | ( [Psychotic disorders linked to the inhibition of benzodiazepine catabolism]. Begaud, B; Hugues, FC; Jouglard, J; Le Jeunne, C; Moulin, M, ) | 0.13 |
| " The relapse rate on stopping antibiotics is also significantly less in patients given I g daily and this dosage did not produce any increase in side effects." | ( Evaluation of a therapeutic strategy for the treatment of acne vulgaris with conventional therapy. Burke, B; Cunliffe, WJ; Greenwood, R, 1986) | 0.27 |
| " Doubling of erythromycine dosage could not prevent premenstrual exacerbation of acne." | ( On therapeutic approaches to some special types of acne. Rajka, G, 1985) | 0.64 |
| " In order to select the appropriate dosing intervals, the in vitro post-antibiotic effect (PAE) of clarithromycin and erythromycin were compared and the efficacies of clarithromycin and erythromycin when administered once (q." | ( Effect of dosing intervals on efficacy of clarithromycin and erythromycin in mouse infection models. Fernandes, PB; Hardy, DJ; McDonald, EJ; Ramer, N; Swanson, RN, 1988) | 0.73 |
| "The effects of a new fluorinated macrolide (P-0501A) on drug metabolizing enzymes of rat liver were compared with three erythromycins--the base, the stearate and the estolate--after 7 days of dosing (1." | ( Effects of a new fluorinated macrolide (P-0501A) and other erythromycins on drug metabolizing enzymes in rat liver. Bartosek, I; Casacci, F; Corti, F; De Marchi, F; Guaitani, A; Pacei, E; Villa, P, 1986) | 0.72 |
| " The synthesis of methyltransferase was shown to be gene dosage compensated by Western blot analysis." | ( Translational autoregulation of ermC 23S rRNA methyltransferase expression in Bacillus subtilis. Bechhofer, DH; Denoya, CD; Dubnau, D, 1986) | 0.27 |
| " Patients were assigned at random to receive 4 to 10 days' treatment with either mupirocin applied 3-times daily or one of the oral antibiotics in the dosage normally used by the general practitioner for skin infections." | ( A comparison of the new topical antibiotic mupirocin ('Bactroban') with oral antibiotics in the treatment of skin infections in general practice. Ah Chan, M; Fetherston, J; Hague, IK; Haycock, D; Hunter, P; Kanji, K; Robertson, WD; Villiger, JW, 1986) | 0.27 |
| " The induction of cytochrome P-450p and UDP-GT-dt1 by PCN followed similar dose-response curves." | ( Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase. Arlotto, MP; Klaassen, CD; Parkinson, A; Sonderfan, AJ, 1987) | 0.27 |
| "Current antimicrobial dosing regimens are designed to maintain active drug levels for most of the dosing interval and are based on 40-y-old observations." | ( Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. Craig, WA; Ebert, S; Gudmundsson, S; Leggett, J; Turnidge, J; Vogelman, B, 1988) | 0.27 |
| " The pivampicillin dosage was 700 mg twice a day and the erythromycin dosage 500 mg twice a day for seven days." | ( Pivampicillin compared with erythromycin for treating women with genital Chlamydia trachomatis infection. Cramers, M; From, E; Kaspersen, P; Møller, BR, 1988) | 0.81 |
| "A comparison was made of cefatrizine in dosages of 75 mg/kg/day administered once daily or twice daily and erythromycin in a mean daily dosage of 50 mg/kg given in three divided doses for the treatment of acute infections of the ear, nose, and throat in children." | ( Comparison of cefatrizine and erythromycin for pediatric ear, nose, and throat infections. Ciampini, M; Cremonesi, G; Stura, M; Tarantino, V, 1987) | 0.77 |
| "Roxithromycin in two dosage regimens was compared with erythromycin in the therapy of 227 patients with throat infectious due to Streptococcus pyogenes." | ( Roxithromycin in the therapy of Streptococcus pyogenes throat infections. Herron, JM, 1987) | 0.52 |
| " These results suggest that flurithromycin can inhibit the conversion of CBZ to CBZ-E, although, at the dosage tested, the magnitude of this effect was significantly smaller than that observed after administration of erythromycin in the same subjects." | ( Effect of flurithromycin, a new macrolide antibiotic, on carbamazepine disposition in normal subjects. Amione, C; Barzaghi, N; Crema, F; Faja, A; Gatti, G; Leone, L; Monteleone, M; Perucca, E, 1988) | 0.46 |
| " The dosage of EA was 400 mg tid and that of ES 500 mg tid." | ( Efficacy and tolerability of erythromycin acistrate and erythromycin stearate in acute skin infections of patients with atopic eczema. Antikainen, R; Brandt, H; Gordin, A; Salo, OP, 1988) | 0.57 |
| " The dosage of EA was 400 mg tid and that of the two erythromycin base preparations 500 mg tid." | ( Treatment of respiratory tract infections with erythromycin acistrate and two formulations of erythromycin base. Flygare, U; Hildén, M; Hurme, J; Järvinen, H; Leskinen, J; Pynnönen, S; Riikonen, A; Salomaa, V; Seuri, M; Wuolijoki, E, 1988) | 0.78 |
| " The dosage of EA was 400 mg tid and that of ES 500 mg tid." | ( Erythromycin acistrate and erythromycin stearate in the treatment of non-gonococcal urethritis. Antikainen, R; Gordin, A; Rostila, T; Visa, K, 1988) | 1.72 |
| " In Study II, the effect of food on the bioavailability of the two EB preparations was studied after a single dose of 500 mg (2 x 250 mg enterocoated tablets) and after multiple dosing (2 x 250 mg tid)." | ( Absorption of erythromycin acistrate and erythromycin base in the fasting and non-fasting state. Männistö, PT; Pohto, P; Solkinen, A; Tuominen, RK; Vuorela, A, 1988) | 0.64 |
| "The drug concentration in plasma, suction skin blister fluid (SBF), urine and saliva after repeated dosage of either erythromycin acistrate (EA) or enterocoated pellets of erythromycin base (EB) was studied in young healthy volunteers with a cross-over design in two separate studies." | ( Antibiotic concentration in suction skin blister fluid and saliva after repeated dosage of erythromycin acistrate and erythromycin base. Haataja, H; Männistö, PT; Pohto, P; Solkinen, A; Tuominen, RK; Vuorela, A, 1988) | 0.7 |
| "Concentrations of erythromycin and 2'-acetyl erythromycin were analysed in serum or plasma and tonsil tissue after repeated dosage of erythromycin acistrate (EA), a new erythromycin prodrug, in two separate studies in 61 young patients." | ( Tonsillar penetration of erythromycin and its 2'-acetyl ester in patients with chronic tonsillitis. Antikainen, R; Gordin, A; Haataja, H; Männistö, PT; Savolainen, S; Tuominen, RK; Ylikoski, J, 1988) | 0.91 |
| " The dosage of EA was 400 mg tid and that of EB 500 mg tid, and the treatment period ranged from seven to 14 days." | ( Comparison of erythromycin acistrate and enterocoated erythromycin base in acute respiratory infections. Antikainen, R; Gordin, A; Hulmi, S; Kalima, S; Mäkelä, P, 1988) | 0.64 |
| " The dosage of EA was 400 mg tid and that of EB 500 mg tid." | ( Erythromycin acistrate and enterocoated pellets of erythromycin base in acute respiratory infections of hospitalized conscripts. Antikainen, R; Gordin, A; Salmi, HA, 1988) | 1.72 |
| " Oral penicillin V in a dosage of 250 mg, twice daily for ten days, affords optimal treatment for children." | ( Treatment of streptococcal pharyngitis revisited. Bass, JW, 1986) | 0.27 |
| " The increased dosage and duration and the early initiation of treatment resulted in survival rates of 75%." | ( [Treatment with erythromycin of experimental legionellosis in guinea pigs infected by aerosol]. Binder, P; Bornstein, N; Fleurette, J; Forey, F; Nowicki, M; Paucod, JC, 1986) | 0.62 |
| " infusion over 15 min in the presence and absence of chronic dosing with slow-release theophylline." | ( The interaction between chronic oral slow-release theophylline and single-dose intravenous erythromycin. Chaput de Saintonge, DM; Downey, K; Jackson, SH; Johnston, A; Pasic, J; Peverel-Cooper, CA; Turner, P, 1987) | 0.49 |
| "A cardiac patient had to be given a very high dosage of digoxin to attain therapeutic plasma level." | ( The significance of the enterohepatic circulation on the metabolism of digoxin in patients with the ability of intestinal conversion of the drug. Klitgaard, NA; Nørregaard-Hansen, K; Pedersen, KE, 1986) | 0.27 |
| " Of course, overall expense for the hospitalized patient includes costs of tests for monitoring for toxicity as well as administration costs, which are affected by the dosing frequency." | ( Choosing antimicrobials. Factors to consider, available agents. Pankey, GA; Valainis, GT, 1985) | 0.27 |
| " Twenty-four volunteers participated in a ten-dose protocol (one dosage unit every six hours) using a complete crossover design." | ( Bioinequivalence of erythromycin ethylsuccinate and enteric-coated erythromycin pellets following multiple oral doses. Feis, PJ; Rasmussen, CE; Wallen, S; Yakatan, GJ, ) | 0.45 |
| " A significant dose-response effect was found with both amoxicillin and trimethoprim/sulfamethoxazole." | ( Antibiotic-associated gastrointestinal symptoms in general pediatric outpatients. Contardi, R; Flegel, KM; Hutchinson, TA; Kramer, MS; Leduc, DG; Naimark, L, 1985) | 0.27 |
| " Concurrent administration of triacetyloleandomycin with drugs whose metabolism is known to be affected or that could potentially be affected should be avoided unless appropriate adjustments in dosage are made." | ( Pharmacokinetic interactions of the macrolide antibiotics. Ludden, TM, ) | 0.13 |
| " An adequate dosage should be used (50 to 100 mg/kg/24 h) divided into four oral doses given at six hour intervals." | ( [Haemophilus influenzae infections in infants and macrolides. Importance of the choice of an effective antibiotic and compliance with its administration schedule]. Geslin, P; Lemerle-Gruson, S; Pesnel, G; Reinert, P; Squinazi, F, 1985) | 0.27 |
| " For these reasons and based on results of the published clinical studies, the appropriate daily dosage for erythromycin estolate is 20 to 30 mg/kg/day and that for erythromycin ethylsuccinate is 40 mg/kg/day." | ( Erythromycin in the treatment of streptococcal infections. Derrick, CW; Reilly, KM; Stallworth, JR, ) | 1.79 |
| " At 1 week before (1 dose) and at 48, 60, and 72 hours (3 doses) after Pasteurella administration, the calves were given erythromycin at a dosage of 15 mg/kg, and the pharmacokinetic values were determined." | ( Effects of experimentally induced Pasteurella haemolytica pneumonia on the pharmacokinetics of erythromycin in the calf. Burrows, GE, 1985) | 0.7 |
| " The new sulfa-trimethoprim combination showed activity similar to the reference drug, but it may have the advantage of a simpler dosage schedule." | ( Double-blind comparative trial of trimethoprim/sulfamethopyrazine once daily vs erythromycin 4 X daily in patients with ENT infections. Federspil, P; Koch, J, 1983) | 0.49 |
| " In the present investigation a group of children with OME of more than three months' duration were given erythromycin (Abboticin) in standard dosage for the last 10 days prior to scheduled operation (paracentesis or tympanostomy)." | ( Erythromycin in the treatment of otitis media with effusion (OME). Ernstson, S; Sundberg, L, 1984) | 1.92 |
| " One group remained untreated, whereas the other received erythromycin ethylsuccinate (Abboticin) in standard dosage for the last 10 days before surgery." | ( The effect of erythromycin on the nasopharyngeal pathogens in children with secretory otitis media. Cederberg, A; Edén, T; Ernstson, S; Sundberg, L, ) | 0.74 |
| " Sodium fusidate and erythromycin at the recommended dosage of 30 mg/kg/d for 3 weeks was found to be an effective first-line antibiotic regimen." | ( Acute osteomyelitis and septic arthritis in children. A simple approach to treatment. Dall, G; Learmonth, ID; Pollock, DJ, 1984) | 0.59 |
| "In a clinical and bacteriological study of 42 patients with acute tonsillo-pharyngitis or chronic tonsillo-pharyngitis with acute exacerbation, patients were allocated at random to receive either a 3-day course of spiramycin or a 5-day course of erythromycin, both antibiotics being given in a dosage of 500 mg 3-times daily." | ( A comparative study of spiramycin and erythromycin in acute tonsillo-pharyngitis. Efiaty, S; Fachri, H; Iskandar, N; Yunisaf, MH, 1984) | 0.72 |
| " This study indicates that ion-trapping in forestomach fluid as a result of normal dietary changes does not require therapeutic dosage adjustment." | ( Serum erythromycin concentration in sheep fed two diets. Goetsch, DD; Huber, TL; Wilson, RC, 1984) | 0.75 |
| " Oral erythromycin ethyl succinate in a paediatric dosage form was administered to one group and topical 1% tetracycline ointment to the other group, twice daily, six days a week for three weeks." | ( Trachoma therapy with topical tetracycline and oral erythromycin: a comparative trial. Daghfous, T; Dawson, CR; Hoshiwara, I; Kamoun, M; Ramdhane, K; Schachter, J; Yoneda, C, 1982) | 1 |
| " For those patients with theophylline levels at the higher end of the therapeutic range (15 to 20 micrograms/ml), we recommend an initial 25% reduction in theophylline dosage when erythromycin is added." | ( The effect of erythromycin on theophylline pharmacokinetics in chronic bronchitis. Melethil, S; Pingleton, SK; Reisz, G; Ryan, PB, 1983) | 0.82 |
| " Recommendations were made for drug dosage to be used in the treatment of Corynebacterium equi pneumonia of foals." | ( Pharmacokinetics of erythromycin in foals and in adult horses. Dohoo, IR; Hoover, DJ; Prescott, JF, 1983) | 0.59 |
| " In order to appropriately administer prophylactic antibiotics in the various clinical settings on the surgical service, in which this practice has been of proved value, one must be aware of the following nuances including (1) choice of the antibiotic agent based on the type of organisms usually causing infection, (2) route of its administration, (3) the dosage necessary to attain efficacious tissue or serum levels, and (4) the timing of administration which offers the maximum benefits without risking the adverse effects." | ( Use of prophylactic antibiotics in surgical practice. Nichols, RL, 1981) | 0.26 |
| " Also, it is important to determine the proper dosage of the antimicrobial drug to be used." | ( Oral antibiotics in pedal infections. Green, RA, 1980) | 0.26 |
| " The PAE phenomenon may be of clinical importance with regard to dosage regimens in antimicrobial chemotherapy." | ( [Experimental study of optimal dose interval in antibiotic therapy]. Craig, WA; Gerber, AU, 1982) | 0.26 |
| " Twelve serum samples were collected at 0, 1, 2, 3, 4, 6, 8, 10, 12, 14, 16, and 24 h after dosing and assayed microbiologically for erythromycin concentration." | ( Pharmacokinetics of single-dose erythromycin in normal and alcoholic liver disease subjects. Brown, A; Juhl, RP; Kroboth, FJ; Kroboth, PD; Lyon, JA, 1982) | 0.75 |
| " The serum peaks usually occurred after 2 h irrespective of dosage form given." | ( Dose-related pharmacokinetics after oral administration of a new formulation of erythromycin base. Bergan, T; Josefsson, K; Magni, L, 1982) | 0.49 |
| " The pharmacokinetic results indicate that both dosage alternatives are suitable and result in similar steady-state peak levels, but the initial dose should be 500 mg." | ( Pharmacokinetics of a new, microencapsulated erythromycin base after repeated oral doses. Bergan, T; Josefsson, K; Magni, L; Midtvedt, T; Steinbakk, M, 1982) | 0.52 |
| " Erythromycin ethylsuccinate was given orally in a dosage of 30-60 mg/kg/day and samples of middle ear effusion were obtained at different intervals." | ( The penetration of erythromycin into the middle ear. Edén, T; Ernstson, S; Sundberg, L, 1982) | 1.5 |
| " The difference in half-life does not require dosage adjustment in this patient population." | ( Pharmacokinetics of erythromycin in normal and alcoholic liver disease subjects. Bates, TR; DiSanto, AR; Gibaldi, M; Hall, KW; Nelson, E; Nightingale, CH, 1982) | 0.59 |
| " The linearity and precision of the HPLC assay method for erythromycin in the solid dosage form were examined by spiking erythromycin into a tablet placebo a 60-120% of the label." | ( Improved high-pressure liquid chromatographic method for the analysis of erythromycin in solid dosage forms. Kane, MP; Tsuji, K, 1982) | 0.74 |
| " Each drug was dosed at 50 mg/kg/day and was given every 12 hours in two equally divided doses." | ( Cefadroxil monohydrate versus erythromycin in paediatric patients. Trujillo, H, 1981) | 0.55 |
| " Adjustments of the theophylline dosage may be necessary for patients who take theophylline and erythromycin concurrently to minimize the risk of theophylline toxicity." | ( Depression of theophylline elimination by erythromycin. Gray, JD; Hung, OR; Renton, KW, 1981) | 0.75 |
| " 2 Two clinically attractive oral dosage regimens were administered: erythromycin stearate tablets 1 h before meals (Regimen A), and erythromycin base capsules 30 min after start of meals (Regimen B), each equivalent to erythromycin 250 mg, 6 h apart for 9 doses." | ( Absorption and bioavailability of oral erythromycin. Austin, KL; Mather, LE; McDonald, PJ; Philpot, CR, 1981) | 0.77 |
| "We have investigated the importance of cytochrome P-450IIIA enzyme activity in influencing dosage of the immunosuppressive drugs FK 506 and cyclosporine after liver transplantation." | ( Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients. Cakaloglu, Y; Devlin, J; Tredger, JM; Williams, R, 1994) | 0.29 |
| " Analysis of data from previous studies in our laboratories shows that in the absence of intestinal metabolism, cyclosporine absorption from its presently available dosage form averages at least 65% +/- 12% in healthy volunteers and 77% +/- 19% in kidney transplant patients." | ( Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Benet, LZ; Gomez, DY; Gupta, SK; Hebert, MF; Rowland, M; Wacher, VJ; Wu, CY, 1995) | 0.29 |
| " Urine from mice dosed with up to 200 mg/kg of azithromycin also had no effect on the number of revertants in these same strains suggesting the absence of mutagenic excretory products following oral exposure." | ( Preclinical toxicology studies with azithromycin: genetic toxicology evaluation. Amacher, DE; Ellis, JH; Holden, HE; Joyce, AJ; Muehlbauer, PA; Ray, VA; Turner, GN; Wahrenburg, MG, 1993) | 0.29 |
| " An intravenous dosage of 1g every 6 hours as initial therapy will be effective in most cases." | ( Treatment of Legionnaires' disease. Current recommendations. Carreres, A; Domingo, C; Roig, J, 1993) | 0.29 |
| " However amoxicillin to a sufficient dosage is still enough ("Clinical" Resistance < 1 percent in our sample) for the treatment of respiratory infections except when the MIC is at a high level." | ( [Resistance of Streptococcus pneumoniae to penicillin. "Bacteriological" resistance/"clinical" resistance]. Bignon, J; Defouilloy, C; Fremaux, A; Geslin, P; Mehdaoui, A, 1994) | 0.29 |
| "025), so the dosage was lowered to 250 mg four times a day to complete the course." | ( Azithromycin and erythromycin in the treatment of cervical chlamydial infection during pregnancy. Bush, MR; Rosa, C, 1994) | 0.63 |
| " When stable dosing was achieved, there was a measured 6-fold variation in the ratio of 12-hr whole-blood parent compound trough concentration (ng/ml, HPLC) to daily OG 37-325 dose (mg/kg) ([OG 37-325]/dose)." | ( Prediction of interpatient and intrapatient variation in OG 37-325 dosing requirements by the erythromycin breath test. A prospective study in renal transplant recipients. Annesley, TM; Blake, DS; Leichtman, AB; Lown, KS; Schmouder, RL; Turgeon, DK; Watkins, PB, 1994) | 0.51 |
| "9 micrograms/ml for the 40- and 25-mg/kg/day dosage groups, respectively." | ( Serum concentrations of erythromycin after intravenous infusion in preterm neonates treated for Ureaplasma urealyticum infection. Cassell, GH; Crouse, DT; Duffy, LB; Geerts, MH; Hamrick, WB; Shoup, RE; Sims, PJ; Waites, KB, 1994) | 0.6 |
| " With dirithromycin administered for 14 days or less, no dosage adjustment should be necessary in patients with mild hepatic insufficiency." | ( Pharmacokinetics of dirithromycin in patients with impaired hepatic function. Cerimele, B; DeSante, K; Gereats, D; Janda, R; Johlin, F; LaBreque, D; Lanier, T; Shreves, T; Sides, G, 1993) | 0.29 |
| " This dosage was repeated as needed when symptoms reappeared." | ( Treatment of cyclic vomiting in childhood with erythromycin. Ernst, L; Kaufman, SS; Vanderhoof, JA; Young, R, 1993) | 0.54 |
| " The mean lung azithromycin concentration in infected animals was significantly higher than that in controls 48 h after dosing (12." | ( Azithromycin pharmacokinetics and intracellular concentrations in Legionella pneumophila-infected and uninfected guinea pigs and their alveolar macrophages. Edelstein, MA; Edelstein, PH; Stamler, DA, 1994) | 0.29 |
| " a 12 h dosage interval for multiple doses of erythromycin phosphate or estolate, there were no significant differences observed in AUC(24-28 h), peak-trough plasma concentrations or duration that plasma concentrations exceeded the minimal inhibitory concentration (MIC) for Rhodococcus equi." | ( Comparison of oral erythromycin formulations in the horse using pharmacokinetic profiles. Burrows, G; Clarke, C; Ewing, PJ; MacAllister, C, 1994) | 0.88 |
| " The addition of dirithromycin (500 mg orally once daily at 7:00 AM) to a sustained-release theophylline dosing regimen (every 12 hours) elicited small changes in the steady-state pharmacokinetics of theophylline, which were not statistically significant." | ( Steady-state pharmacokinetics of theophylline in COPD patients treated with dirithromycin. Bachmann, K; Jauregui, L; Sides, G; Sullivan, TJ, 1993) | 0.29 |
| " Due to prolonged half-life it is more suitable for twice daily dosing than the conventional erythromycin preparations." | ( Twice daily dosing of erythromycin acistrate in the treatment of acute bronchitis and pneumonia. Lehtonen, L; Wiesner, B; Wilen-Rosenqvist, G, 1993) | 0.82 |
| " Prior to perfusion experiments, oral dosing was carried out for three days on three groups of male Sprague-Dawley rats (300-350 g), involving pretreatment with water (control and H2O/Ery groups) or erythromycin (Ery oral group)." | ( Cyclosporin A and erythromycin: a study of a drug interaction in the in situ perfused rat liver model. Collier, PS; Hughes, CM; Swanton, JG, 1993) | 0.81 |
| " The hearing loss was reversible in all cases, and subsided a few days (median = 3) after dosage reduction or drug discontinuation." | ( Erythromycin-induced hypoacusis: 11 new cases and literature review. de Cos, MA; Sacristán, JA; Soto, JA, ) | 1.57 |
| "Erythromycin administered for appropriate indications and dosage adjustments in patients with impaired renal and/or liver function may prevent or reduce the incidence of erythromycin-induced hypoacusis." | ( Erythromycin-induced hypoacusis: 11 new cases and literature review. de Cos, MA; Sacristán, JA; Soto, JA, ) | 3.02 |
| "In 10 anesthetized prairie dogs we determined the motility responses of the duodenum, sphincter of Oddi, and gallbladder to erythromycin infusion during a three-log dosing regimen and correlated activity with serum concentrations of the drug." | ( The effect of erythromycin on motility of the duodenum, sphincter of Oddi, and gallbladder in the prairie dog. Ahrendt, SA; Kaufman, HS; Lillemoe, KD; Pitt, HA, 1993) | 0.85 |
| " Clinical and bacteriological efficacy, excellent tolerability, simplified dosage (single daily dose) and short-course (3 days) therapeutic regimen make azithromycin, in our experience, efficacious for the treatment of acute exacerbation of chronic bronchitis and community-acquired pneumonia." | ( Clinical efficacy of azithromycin in lower respiratory tract infections. Carnimeo, NS; Foschino, MP; Miragliotta, G; Morandini, G; Perduca, M; Zannini, G, 1993) | 0.29 |
| " The treatment-related differences seen in the plasma concentrations were as expected from the different dosage schedules." | ( Comparison of the pharmacokinetics of three-day and five-day regimens of azithromycin in plasma and urine. Laufen, H; Leitold, M; Wildfeuer, A; Zimmermann, T, 1993) | 0.29 |
| " Therefore, no dosage modifications of azithromycin seem to be required for patients with class A or B liver cirrhosis." | ( Pharmacokinetics of azithromycin in patients with impaired hepatic function. Carlà, V; Crispo, A; Fallani, S; Mazzei, T; Novelli, A; Periti, P; Surrenti, C; Surrenti, E, 1993) | 0.29 |
| " Azithromycin (10 mg/kg/day) was administered as a single dose for three days and co-amoxiclav was given tid for ten days at a dosage according to the manufacturer's instructions for the country." | ( Comparison of azithromycin and co-amoxiclav in the treatment of otitis media in children. Daniel, RR, 1993) | 0.29 |
| " The dosage schedule for azithromycin was 10 mg/kg/day, in a single daily dose, administered for three days." | ( Multicentre evaluation of azithromycin in comparison with co-amoxiclav for the treatment of acute otitis media in children. Schaad, UB, 1993) | 0.29 |
| "The objective of this study was to investigate the effects of intravenous erythromycin and chronic oral dosing of erythromycin on gastric emptying in patients with idiopathic or diabetic gastroparesis." | ( The treatment of idiopathic and diabetic gastroparesis with acute intravenous and chronic oral erythromycin. Davenport, K; McCallum, RW; Richards, RD, 1993) | 0.74 |
| " Erythromycin, in the dosage tested in this study, does not seem to alter clinical parameters of gastrointestinal motility after an abdominal operation." | ( Effect of intravenous erythromycin on postoperative ileus. Bonacini, M; Gaddis, M; Pemberton, B; Quiason, S; Reynolds, M; Smith, O, 1993) | 1.51 |
| " endometrium, myometrium, ovary and Fallopian tube, as well as in plasma, were determined after oral dosing of erythromycin acistrate (EA, CAS 96128-89-1), a erythromycin prodrug." | ( Erythromycin and 2'-acetyl erythromycin concentrations in plasma and pelvic tissues after repeated doses of erythromycin acistrate. Karhunen, M; Kokkonen, P; Lehtonen, L; Tuominen, R; Wikberg, R, 1993) | 1.94 |
| " Dirithromycin was administered orally at a dosage of 500 mg once daily and miocamycin was administered orally at a dosage of 600 mg twice daily; the duration of therapy was five to seven days for both drugs." | ( Clinical efficacy of dirithromycin versus miocamycin in the treatment of acute bronchitis or acute exacerbations of chronic bronchitis. Pozzi, E, 1993) | 0.29 |
| " This study was designed to evaluate the additive effect of continuous low dosage or intermittent usual dosage of ofloxacin (OFLX) on EM therapy in patients with sinobronchial syndrome." | ( Additive effect of continuous low-dose ofloxacin on erythromycin therapy for sinobronchial syndrome. Fujimura, M; Ishiura, Y; Matsuda, T; Nakatsumi, Y; Nomura, M; Saito, M; Shibata, K, 1995) | 0.54 |
| " The dosage of the antibiotic used can be markedly reduced by optimizing a vehicle for the ion pair." | ( Optimization of topical erythromycin formulations by ion pairing. Matschiner, S; Neubert, R; Wohlrab, W, 1995) | 0.6 |
| " In this study, we have been able to demonstrate the usefulness of a reproducible long-time antimicrobial dosage regime from the internal phase of the implant as compared to surface coated polymers." | ( Drug delivery concepts for the efficacious prevention of foreign-body infections. Pulverer, G; Rump, A; Schierholz, JM, 1996) | 0.29 |
| " The pharmacokinetic profile of dirithromycin offers the advantages of once-daily dosing and high and prolonged tissue concentrations; dosing adjustments are not needed in the elderly or in patients with renal or mild hepatic impairment." | ( Dirithromycin: a new macrolide. Abdel-Rahman, SM; Nahata, MC; Wintermeyer, SM, 1996) | 0.29 |
| " The long elimination half-life of dirithromycin allows once-daily dosing and higher and more prolonged tissue concentrations than are achievable with erythromycin." | ( Dirithromycin: a new macrolide. Abdel-Rahman, SM; Nahata, MC; Wintermeyer, SM, 1996) | 0.49 |
| " Being as efficacious as penicillin and having the advantages over erythromycin of once-daily dosing and the lack of drug interactions, dirithromycin is an alternative to penicillin in the treatment of streptococcal pharyngitis for patients 12 years of age and older." | ( Comparison of dirithromycin and penicillin for treatment of streptococcal pharyngitis. Conforti, PM; Huck, W; Sides, GD; Smietana, M; Watkins, VS, 1997) | 0.53 |
| "Dirithromycin is a new macrolide antimicrobial drug with a long half-life (44 hours) that reaches high tissue concentrations, thus permitting once-daily oral dosing and shorter courses of therapy." | ( Clinical efficacy of dirithromycin in patients with bacteremic pneumonia. Conforti, PM; Hernández, JM; Sides, GD; Smietana, MG, ) | 0.13 |
| "A case of repetitive hallucinations during treatment with a therapeutic dosage of triazolam (0." | ( Hallucinations after a therapeutic dose of benzodiazepine hypnotics with co-administration of erythromycin. Kaneko, S; Kondo, T; Mihara, K; Morita, S; Otani, K; Tokinaga, N, 1996) | 0.51 |
| " The shorter duration of therapy and the once daily dosing with good efficacy against common respiratory pathogens would be advantageous for patients and would be likely to promote better patient compliance and acceptability." | ( Pulmonary concentrations of dirithromycin and erythromycin during acute exacerbation of mild chronic obstructive pulmonary disease. Cazzola, M; Matera, MG; Polverino, M; Rossi, F; Tufano, MA, 1997) | 0.56 |
| " This novel information may be useful for the rational development of dosage schedules and may improve predictions regarding therapeutic outcome." | ( Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans. Agneter, E; Burgdorff, T; Eichler, HG; Georgopoulos, A; Haag, O; Jansen, B; Müller, M; Pehamberger, H; Stanek, G; Weninger, W, 1996) | 0.29 |
| " There were no significant differences found between the dosing frequencies and levels of killing when examining each isolate separately." | ( Pharmacodynamics of RP 59500 (quinupristin-dalfopristin) administered by intermittent versus continuous infusion against Staphylococcus aureus-infected fibrin-platelet clots in an in vitro infection model. Houlihan, HH; Kaatz, GW; Mercier, RC; Rybak, MJ, 1997) | 0.3 |
| " This study shows that a 5-day dirithromycin therapy provides a convenient and efficient dosage regimen in acute exacerbation of chronic bronchitis." | ( A five-day course of dirithromycin in the treatment of acute exacerbation of severe chronic obstructive pulmonary disease. Caputi, M; Cazzola, M; Diu Vinciguerra, A; Perna, FD; Polverino, M; Santangelo, G, 1997) | 0.3 |
| " In addition, a constant dosage of SPFX and SYN 1193, in combination with varying dosages of erythromycin, was tested under similar experimental conditions." | ( The effects of macrolide and quinolone antibiotics in methicillin-resistant Staphylococcus aureus biofilm growth. Dasgupta, MK; Larabie, M; Micetich, RG; Salama, S; Shishido, H; Singh, R, 1997) | 0.52 |
| " (2) In phase I-II human studies, classic pharmacokinetic measurements can be coupled with imaging measurements (a) to define optimal dosing schedule; (b) to define the potential utility of interventions in particular clinical situations; and (c) to formulate the design of phase III studies that are crucial for drug licensure." | ( The role of positron emission tomography in pharmacokinetic analysis. Alpert, NM; Babich, JW; Fischman, AJ; Rubin, RH, 1997) | 0.3 |
| " The experiments were of randomized cross-over design with a two-week wash-out period between dosing regimens." | ( Inhibition of nifedipine metabolism in dogs by erythromycin: difference between the gut wall and the liver. Arimori, K; Nakamura, K; Nakano, M; Tsuruta, S, 1997) | 0.55 |
| " The rate of absorption of sertindole and the rate of appearance of dehydrosertindole in the systemic circulation after a 4-mg sertindole single dose were slightly enhanced by concomitant dosing of erythromycin." | ( The effect of erythromycin on the CYP3A component of sertindole clearance in healthy volunteers. Cao, G; Granneman, GR; Mack, RJ; Wong, SL, 1997) | 0.85 |
| "0 mg/kg dosage of ERY (76." | ( Effect of erythromycin lactobionate on myoelectric activity of ileum, cecum, and right ventral colon, and cecal emptying of radiolabeled markers in clinically normal ponies. Lester, GD; Merritt, AM; Neuwirth, L; Rice, B; Steible, C; Vetro-Widenhouse, T, 1998) | 0.7 |
| "In this study, we determined the efficacy of various dosing regimens for erythromycin and azithromycin against four pneumococci with different susceptibilities to penicillin in an in vitro pharmacokinetic model and in a mouse peritonitis model." | ( Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo. den Hollander, JG; Espersen, F; Frimodt-Møller, N; Fuursted, K; Knudsen, JD; Mouton, JW; Verbrugh, HA, 1998) | 0.78 |
| " Thirty healthy volunteers received one of five oral doses of EM574 (5, 10, 20, 30 mg and placebo) in a randomized, double-blind, five-period, cross-over design; each dosing period was separated by 1-wk washout." | ( Dose-related effects of N-demethyl-N-isopropyl-8, 9-anhydroerythromycin A 6,9-hemiacetal on gastric emptying of solids in healthy human volunteers. Burton, DD; Camilleri, M; Choi, MG; Edmonds, A; Johnson, S, 1998) | 0.54 |
| " While the mean AUC of the metabolite M1 following the combined dosing was decreased by 60% compared with mono-dosing, the mean AUC of M23 exhibited an increase of approximately 60%." | ( Influence of erythromycin pre- and co-treatment on single-dose pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin. Kuhlmann, J; Mück, W; Ochmann, K; Rohde, G; Unger, S, 1998) | 0.67 |
| "The relative in-vivo intracellular concentration of various macrolides in phagocytes cannot be directly extrapolated from in-vitro experiments that use a fixed and constant extracellular concentration for all compounds, since this fails to consider different rates of intracellular penetration, dosage regimens and pharmacokinetic data." | ( Computer-aided prediction of macrolide antibiotic concentrations in human circulating polymorphonuclear leucocytes. Bouvier d'Yvoire, MJ; Dresco, IA; Tulkens, PM, 1998) | 0.3 |
| " Ciprofloxacin is better in terms of dosage schedule, duration of treatment, and low cost." | ( A comparative study of therapeutic response of patients with clinical chancroid to ciprofloxacin, erythromycin, and cotrimoxazole. D'Souza, P; Khanna, N; Misra, RS; Pandhi, RK; Rattan, A, 1998) | 0.52 |
| "To determine the optimal dosage form of erythromycin for use as a prokinetic agent." | ( Which form of erythromycin should be used to treat gastroparesis? A pharmacokinetic analysis. Ehrenpreis, ED; Nellans, H; Zaitman, D, 1998) | 0.93 |
| "Based on the kinetic data from this study, erythromycin suspension is the ideal dosage form for administration of this drug as a prokinetic agent." | ( Which form of erythromycin should be used to treat gastroparesis? A pharmacokinetic analysis. Ehrenpreis, ED; Nellans, H; Zaitman, D, 1998) | 0.92 |
| " These techniques have been applied to the separation and quantitative analysis of the macrolides in fermentation media, purity assessment of raw materials, assay of pharmaceutical dosage forms and the measurement of clinically useful macrolide antibiotics in biological samples such as blood, plasma, serum, urine and tissues." | ( Analysis of macrolide antibiotics. Kanfer, I; Skinner, MF; Walker, RB, 1998) | 0.3 |
| " As an alternative, the dosage of simvastatin should be reduced considerably, that is, by about 50% to 80%, at least when a simvastatin dosage higher than 20 mg/day is used." | ( Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations. Kantola, T; Kivistö, KT; Neuvonen, PJ, 1998) | 1.74 |
| "Although it is important to maintain an appropriate blood concentration of FK506 after liver transplantation, significant interindividual variability in the actual FK506 dosage has been observed, presumably due to the wide variability of cytochrome P450 3A4 activity in liver microsomes." | ( Relationship between in vivo FK506 clearance and in vitro 13-demethylation activity in living-related liver transplantation. Chisuwa, H; Hashikura, Y; Ikegami, T; Iwasaki, K; Katsuyama, Y; Kawasaki, S; Nakazawa, Y; Terada, M, 1998) | 0.3 |
| " Although coadministration of EM with DP gave enhanced QT prolongation compared to dosing with DP alone, EM did not affect the pharmacokinetics of DP." | ( Pharmacodynamic analysis of the electrocardiographic interaction between disopyramide and erythromycin in rats. Hanada, E; Iga, T; Kotaki, H; Ohtani, H; Sato, H; Sawada, Y, 1999) | 0.52 |
| "The therapeutic dosage of erythromycin significantly suppressed acute neutrophil influx into the lung, intradermal Arthus reaction and the expression of ICAM-1 in the lesions of experimental EAA." | ( Effects of erythromycin on experimental extrinsic allergic alveolitis. Ando, M; Ito, K; Miyajima, M; Nakagawa, K; Suga, M, 1999) | 0.99 |
| "5 months (range, 1 to 19 months) at a median dosage of 300 mg/day (range, 150 to 1,000 mg/day)." | ( Efficacy of prolonged administration of intravenous erythromycin in an ambulatory setting as treatment of severe gastroparesis: one center's experience. DiBaise, JK; Quigley, EM, 1999) | 0.55 |
| " Clarithromycin is dosed twice/day; dirithromycin's pharmacokinetics allow once/day dosing." | ( Review and comparison of advanced-generation macrolides clarithromycin and dirithromycin. Amsden, GW; McConnell, SA, 1999) | 0.3 |
| " Therefore, coadministration of CYP3A4/5 inhibitors should not require a modification in the dosage of argatroban." | ( Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban. Benincosa, LJ; Di Cicco, RA; Hursting, MJ; Jorkasky, DK; Peng, L; Sheth, SB; Tran, JQ; Tucci, M, 1999) | 0.53 |
| " Azithromycin and clarithromycin have pharmacokinetics that allow shorter dosing schedules because of prolonged tissue levels." | ( The macrolides: erythromycin, clarithromycin, and azithromycin. Alvarez-Elcoro, S; Enzler, MJ, 1999) | 0.65 |
| "These results demonstrate that erythromycin at a clinically relevant dosage does not inhibit the metabolism of clozapine." | ( Absence of interaction between erythromycin and a single dose of clozapine. Dahlqvist, R; Granberg, K; Hägg, S; Mjörndal, T; Persbo-Lundqvist, G; Spigset, O, 1999) | 0.88 |
| " Therefore, on the limited basis of single-dose administration, no modifications of dirithromycin dosage seem to be required even for patients with class B liver cirrhosis." | ( Pharmacokinetics of dirithromycin in patients with mild or moderate cirrhosis. Biagini, MR; Cassetta, MI; Conti, S; Fallani, S; Mazzei, T; Novelli, A; Surrenti, C; Surrenti, E, 1999) | 0.3 |
| " On each study day, blood was sampled up to 8 h after dosing for assessment of desmopressin concentration." | ( Changes in gastrointestinal motility influence the absorption of desmopressin. Bengtsson, P; Callréus, T; Höglund, P; Lundahl, J, 1999) | 0.3 |
| "Intravenous and oral verapamil clearance values were significantly correlated, and cumulative dextromethorphan/3-methoxymorphinan urinary ratios correlated with both plasma AUC(norverapamil)/AUC(verapamil) after oral verapamil dosing and with oral and intravenous verapamil clearance." | ( In vivo comparison of putative probes of CYP3A4/5 activity: erythromycin, dextromethorphan, and verapamil. Barnas, CR; Gorski, JC; Krecic-Shepard, ME; Schwartz, JB; Slimko, J; Wainer, IW, 1999) | 0.55 |
| "The newer macrolide antibiotics offer the advantage of fewer adverse gastrointestinal effects than erythromycin and dosing regimens of only once or twice a day." | ( Dental therapeutic indications for the newer long-acting macrolide antibiotics. Moore, PA, 1999) | 0.52 |
| " The febrile condition resulted in an alteration in the disposition kinetics of erythromycin suggesting an adjustment of the dosage under febrile conditions." | ( Disposition kinetics of erythromycin in normal and experimentally-induced febrile rabbits. Ahmad, M; Ahmad, T; Bukhari, NI, ) | 0.67 |
| " The interindividual response to omeprazole in intragastric pH elevation under the study dosage had insignificant variations to alter the success of eradication." | ( A three-day course of intravenous omeprazole plus antibiotics for H. pylori-positive bleeding duodenal ulcer. Chi, CH; Jen, CM; Lin, XZ; Sheu, BS; Yang, HB, ) | 0.13 |
| "The direct effect of both erythromycin and motilin was a slight increase (less than 10% of the maximal ACh-induced contraction) in the basal tension, with no dose-response relationship." | ( Effects of erythromycin on human colonic circular muscle in idiopathic chronic constipation. Altomare, DF; Chieppa, DM; De Salvia, MA; Mansi, G; Mitolo, CI; Montagnani, M; Nacci, C; Potenza, MA; Rinaldi, M; Rinaldi, R; Serio, M, 2000) | 1 |
| " A pharmacokinetic interaction occurs when amprenavir and clarithromycin are coadministered, but the effects are not likely to be clinically important, and coadministration does not require a dosage adjustment for either drug." | ( Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers. Brophy, DF; Chittick, GE; Gillotin, C; Israel, DS; Lou, Y; Pastor, A; Polk, RE; Sadler, BM; Symonds, WT, 2000) | 0.31 |
| " A randomized, double-blind, placebo-controlled, three-period incomplete crossover design was used with three dosing periods of 7 days." | ( The effect of motilin agonist ABT-229 on gastro-oesophageal reflux, oesophageal motility and lower oesophageal sphincter characteristics in GERD patients. Samsom, M; Smout, AJ; Van Herwaarden, MA; Van Nispen, CH; Verlinden, M, 2000) | 0.31 |
| " The significant PAE described here, combined with favourable pharmacokinetics, supports once-daily dosing for gemifloxacin in the treatment of legionella infections." | ( Comparative in vitro activity and post-antibiotic effect of gemifloxacin against Legionella spp. Dubois, J; St-Pierre, C, 2000) | 0.31 |
| "To evaluate dose-response effects of motilin and erythromycin on gastric emptying, small bowel and colonic transit in the dog using a validated scintigraphic technique." | ( Motilides accelerate regional gastrointestinal transit in the dog. Allen, RG; Chiba, T; Kost, LJ; Phillips, SF; Thomforde, GM, 2000) | 0.56 |
| "25 microg/ml (reported minimum inhibitory concentration for Rhodococcus equi) for at least 4 hours after intragastric administration of erythromycin phosphate or erythromycin estolate, suggesting that the recommended dosage for either formulation (25 mg/kg, q 6 h) should be adequate for treatment of R equi infections in foals." | ( Pharmacokinetics of erythromycin estolate and erythromycin phosphate after intragastric administration to healthy foals. Lakritz, J; Marsh, AE; Mihalyi, JE; Wilson, WD, 2000) | 0.83 |
| " The dosage of 25 mg/kg every 8 hours, PO, appears appropriate." | ( Effects of prior feeding on pharmacokinetics and estimated bioavailability after oral administration of a single dose of microencapsulated erythromycin base in healthy foals. Lakritz, J; Marsh, AE; Mihalyi, JE; Wilson, WD, 2000) | 0.51 |
| " Antibiotic consumption was expressed in defined daily dosage (DDD)/1000 inhabitants/day." | ( Streptococcus pneumoniae resistance to erythromycin and penicillin in relation to macrolide and beta-lactam consumption in Spain (1979-1997). Aguilar, L; Baquero, F; Casal, J; Dal-Ré, R; García-Rey, C; Granizo, JJ, 2000) | 0.58 |
| " These data demonstrate that multiple dosing of simvastatin, at the highest recommended clinical dose, does not significantly alter the in vivo hepatic or intestinal CYP3A4/5 activity as measured by the commonly used EBT and oral midazolam probes." | ( Simvastatin does not affect CYP3A activity, quantified by the erythromycin breath test and oral midazolam pharmacokinetics, in healthy male subjects. Brucker, MJ; Gagliano, K; Gillen, L; Greenberg, HE; McLoughlin, D; Prueksaritanont, T; Rogers, JD; Vega, JM; Waldman, SA; Wong, PH, 2000) | 0.55 |
| "When intermittent dosing is used during treatment, the concentrations of antibiotics fluctuate and subinhibitory concentrations may occur between doses." | ( Postantibiotic effects and postantibiotic sub-MIC effects of erythromycin, roxithromycin, tilmicosin, and tylosin on Pasteurella multocida. Lim, J; Yun, H, 2001) | 0.55 |
| "5) times the maximum observed plasma drug concentration and the area under the time course of the plasma concentrations up to the last quantifiable concentration after dosing of unchanged DHEC (determined by radioimmunoassay)." | ( Erythromycin increases plasma concentrations of alpha-dihydroergocryptine in humans. Althaus, M; de Mey, C; Ezan, E; Retzow, A, 2001) | 1.75 |
| " After intragastric erythromycin, the authors determined 1) the occurrence and characteristics of phase III of migrating motor complexes, 2) the antral and duodenal motor responses, and 3) the dose-response relation among preterm and full-term infants." | ( Effect of erythromycin on gastroduodenal contractile activity in developing neonates. Berseth, CL; Jadcherla, SR, 2002) | 1.04 |
| " The cumulative amount (A(app)) of drug appearing in the systemic circulation was calculated by deconvolution, where the input response was the plasma concentration-time profile during intestinal perfusion and the unit impulse response was the mean profile following intravenous bolus dosing to sham-operated rabbits in a separate experiment." | ( Intestinal absorption and presystemic elimination of the prokinetic agent, EM574, in the rabbit. Cartier, LL; Gan, G; Huang, Y; Sawchuk, RJ; Yang, Z, 2002) | 0.31 |
| " Simulations of these effects were performed for therapeutic intravenous and oral erythromycin dosage regimens." | ( Pharmacokinetic-pharmacodynamic modeling of the inhibitory effect of erythromycin on tumour necrosis factor-alpha and interleukin-6 production. Guchelaar, HJ; Koopmans, RP; Schultz, MJ; van der Poll, T, 2001) | 0.77 |
| " Ketolides have pharmacokinetics which allow once-daily dosing and extensive tissue distribution with very high uptake into respiratory tissues and fluids relative to serum." | ( Ketolides in the treatment of respiratory infections. Hoban, DJ; Zhanel, GG, 2002) | 0.31 |
| "Repeated dosing with erythromycin caused statistically significant increases in the AUC and Cmax of sildenafil (2." | ( The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers. Faulkner, S; Harness, JA; Muirhead, GJ; Taubel, J, 2002) | 0.93 |
| " Azithromycin did not affect the pharmacokinetics of sildenafil; therefore, no adjustment in dosage is necessary for patients receiving these drugs concomitantly." | ( The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers. Faulkner, S; Harness, JA; Muirhead, GJ; Taubel, J, 2002) | 0.61 |
| " These results suggested that adjustment of dosage regimen of EM and CM is required in pathophysiological conditions, but that of LM is not required." | ( Effects of altered plasma alpha-1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis. Kuroha, M; Shimoda, M; Son, DS, 2001) | 0.31 |
| " Subjects took erythromycin (800 mg per day) or clarithromycin (400 mg per day) on the day before digoxin dosing and during the kinetic study, Neither of the macrolides affected serum digoxin concentration-time curves." | ( The effect of erythromycin and clarithromycin on the pharmacokinetics of intravenous digoxin in healthy volunteers. Kotegawa, T; Kuranari, M; Matsuki, S; Morimoto, T; Nakano, S; Otani, Y; Tsutsumi, K, 2002) | 1.03 |
| " Time-course experiments (incubation time from 12 to 48 h) and dose-response curves (concentration of serum ranging from 1 to 30%) have been conducted." | ( Down-regulation of hepatic cytochrome p450 in chronic renal failure: role of uremic mediators. Guévin, C; Leblond, FA; Michaud, J; Naud, J; Pichette, V, 2002) | 0.31 |
| "To evaluate whether a dose-response curve exists for erythromycin, determine the lowest effective dose of erythromycin needed to improve gastric motility, and compare erythromycin's effectiveness with that of metoclopramide in improving gastric emptying." | ( Erythromycin accelerates gastric emptying in a dose-response manner in healthy subjects. Boivin, MA; Carey, MC; Levy, H, 2003) | 2.01 |
| "Erythromycin increased gastric emptying in a dose-response manner." | ( Erythromycin accelerates gastric emptying in a dose-response manner in healthy subjects. Boivin, MA; Carey, MC; Levy, H, 2003) | 3.2 |
| "The efficacy of various dosing regimens of clarithromycin and erythromycin against recently isolated Streptococcus pneumoniae strains was determined in vivo using two animal infection models (mouse peritonitis and thigh infection)." | ( In vivo pharmacodynamic evaluation of clarithromycin in comparison to erythromycin. Arrigucci, S; Cassetta, MI; Fallani, S; Mazzei, T; Novelli, A, 2002) | 0.79 |
| "Eleven volunteers had data available from both dosing periods." | ( The effect of erythromycin on the pharmacokinetics of rosuvastatin. Cooper, KJ; Dane, AL; Martin, PD; Raza, A; Schneck, DW; Warwick, MJ, 2003) | 0.68 |
| "Interindividual variability in dosage requirements of the calcineurin inhibitor immunosuppressive agents cyclosporine and tacrolimus after liver transplantation may result from differences in the CYP3A activity of the liver graft." | ( Relationship between postoperative erythromycin breath test and early morbidity in liver transplant recipients. Dalhoff, K; Kirkegaard, P; Rasmussen, A; Schmidt, LE, 2003) | 0.6 |
| " Whether ERMBT results may be used to individualize dosage of calcineurin inhibitors needs to be explored." | ( Relationship between postoperative erythromycin breath test and early morbidity in liver transplant recipients. Dalhoff, K; Kirkegaard, P; Rasmussen, A; Schmidt, LE, 2003) | 0.6 |
| " In several instances antibiotics were used in very high dosage (three to four times the suggested maximal dose)." | ( [Pleuropulmonary staphylococcal infections in the infant]. JUTRAS, R, 1962) | 0.24 |
| " The low MICs for many strains as well as the PAE and PA-SME demonstrated in this study for telithromycin show promise for increasing the dosing interval of this ketolide, but will need verification by pharmacokinetic/pharmacodynamic and clinical studies." | ( Telithromycin post-antibiotic and post-antibiotic sub-MIC effects for 10 Gram-positive cocci. Appelbaum, PC; Bajaksouzian, S; Jacobs, MR, 2003) | 0.32 |
| " To generate a ketoconazole dosing regimen, the pharmacokinetics of ketoconazole were first determined in the monkey and were found to be consistent with that previously described in the rat, dog, and human." | ( Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey. Azzarano, LM; Kehler, JR; McSurdy-Freed, JE; Morgan, JA; Proksch, JW; Smith, BR; Stelman, GJ; Ward, KW; Zeigler, KS, 2004) | 0.32 |
| " At dosage of 1 mg l(-1), erythromycin affected the growth of both Synechocystis and Lemna with a maximum inhibition of 70 and 20%, respectively." | ( Effects of erythromycin, tetracycline and ibuprofen on the growth of Synechocystis sp. and Lemna minor. Calamari, D; Neilan, BA; Netting, AG; Pomati, F, 2004) | 1.01 |
| "Although prokinetics are commonly used for management of POI in horses there is clearly a need for more controlled studies to define efficacious dosing and a need to develop new prokinetic drugs." | ( Survey of prokinetic use in horses with gastrointestinal injury. Harmon, FA; Nieto, JE; Snyder, JR; Van Hoogmoed, LM, ) | 0.13 |
| "03) and on the fifth day of twice-daily dosing (12." | ( CYP3A5 genotype has a dose-dependent effect on ABT-773 plasma levels. Bukofzer, S; Cassar, SC; Driscoll, RM; Gentile, MC; Gordon, EF; Grimm, DR; Gustavson, LE; Katz, DA; O'dea, RF; Polzin, JE; Rieser, MJ; Williams, LA; Ye, X, 2004) | 0.32 |
| " They also indicated that, as the PAEs of rokitamycin on the M phenotype and inducible resistant strains were comparable with those on susceptible strains, no re-evaluation of therapeutic dosing regimens was required." | ( The post-antibiotic effects of rokitamycin (a 16-membered ring macrolide) on susceptible and erythromycin-resistant strains of Streptococcus pyogenes. Braga, PC; Culici, M; Dal Sasso, M, 2004) | 0.54 |
| " C(max)/90% minimum inhibitory concentration (MIC(90)) ratios, area under the concentration-time curve (AUC)/MIC(90) ratios, intrapulmonary drug exposure ratios, and percent time above MIC(90) during the dosing interval (%T > MIC(90)) were calculated for recently reported respiratory pathogens." | ( Steady-state plasma and intrapulmonary pharmacokinetics and pharmacodynamics of cethromycin. Conte, JE; Golden, JA; Kipps, J; Zurlinden, E, 2004) | 0.32 |
| "Our results indicate that appropriately dosed beta-lactams for empirical therapy are still the treatment of choice, and that macrolides should be used with prudence." | ( Trends of penicillin and erythromycin resistance among invasive Streptococcus pneumoniae in Europe. Bronzwaer, S; Bruinsma, N; Degener, J; Grundmann, H; Hryniewicz, W; Kristinsson, KG; Monen, J; Schrijnemakers, P; Tiemersma, E, 2004) | 0.63 |
| " When quetiapine is co-administered with CYP3A inhibitors such as erythromycin, the dosing regimen should be modified according to quetiapine TDM." | ( Effect of erythromycin on metabolism of quetiapine in Chinese suffering from schizophrenia. Cheng, ZN; Li, HD; Li, KY; Li, X; Peng, WX; Zhang, BK, 2005) | 0.97 |
| " CYP3A4 is the primary enzyme responsible for CYP-mediated metabolism of QTP in clinical therapy dosage in vivo." | ( Metabolic mechanism of quetiapine in vivo with clinical therapeutic dose. Cheng, ZN; Li, HD; Li, KY; Li, X, 2005) | 0.33 |
| " Over 97% of GPs ranked development of paediatric formulations and clearer dosage information more highly than clinical trials as a means to reducing off-label prescribing." | ( Off-label prescribing to children: attitudes and experience of general practitioners. Ekins-Daukes, S; Helms, PJ; McLay, JS; Taylor, MW, 2005) | 0.33 |
| " A flat dosing scheme of both drugs was used to facilitate development of the oral regimen, and because neither drug's clearance is associated with body surface area (BSA), pharmacokinetic and pharmacogenetic endpoints were explored." | ( Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme. Baker, LH; Griffith, KA; Hayes, DF; Rae, JM; Schott, AF; Sterns, V, 2006) | 0.33 |
| "A non-BSA based dosing scheme of capecitabine and vinorelbine is safe and efficacious." | ( Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme. Baker, LH; Griffith, KA; Hayes, DF; Rae, JM; Schott, AF; Sterns, V, 2006) | 0.33 |
| " They include updated information on macrolide agents other than erythromycin (azithromycin and clarithromycin) and their dosing schedule by age group." | ( Recommended antimicrobial agents for the treatment and postexposure prophylaxis of pertussis: 2005 CDC Guidelines. Moran, J; Murphy, TV; Tiwari, T, 2005) | 0.57 |
| "A single dose of fexofenadine hydrochloride (60 mg as solution) was applied under fasting conditions, either alone or directly after a solution of erythromycin lactobionate (corresponding to a dose of 250 mg erythromycin), to the jejunum, ileum and colon in 6 healthy volunteers (3 male and 3 female) using a regional intubation dosing technology (Bioperm AB, Lund, Sweden)." | ( Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers. Bondesson, U; Borga, O; Hedeland, M; Lennernas, H; Nyberg, L; Petri, N, 2006) | 0.94 |
| " Treatment options for uncomplicated urogenital infections include a single 1-g dose of azithromycin orally, or doxycycline at a dosage of 100 mg orally twice per day for seven days." | ( Diagnosis and treatment of Chlamydia trachomatis infection. Miller, KE, 2006) | 0.33 |
| " The semimechanistic model that was developed might, after further refinement, serve as a tool for the development of optimal dosing strategies for antibacterial agents." | ( Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments. Cars, O; Karlsson, MO; Löwdin, E; Nielsen, EI; Sandström, M; Viberg, A, 2007) | 0.34 |
| " Applications of these pharmacokinetic/pharmacodynamic models will eventually provide a tool for rational antibiotic dosing regimen decisions." | ( Pharmacokinetic/pharmacodynamic modeling of in vitro activity of azithromycin against four different bacterial strains. Derendorf, H; Rand, KH; Schmidt, S; Suvanakoot, U; Treyaprasert, W, 2007) | 0.34 |
| "0 mg kg(-1) established according to the reported lowest dosage of additive needed to lead a growth promoting effect." | ( Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chromatography with electrochemical detection (HPLC-ECD). González de la Huebra, MJ; Vincent, U; von Holst, C, 2007) | 0.34 |
| "0% were obtained with a considerable degree of accuracy when the suggested methods were applied to analysis of synthetic binary mixtures, some commercial dosage forms such as tablets and oral suspension without interference from the commonly encountered excipients and additives." | ( Determination of two antibacterial binary mixtures by chemometrics-assisted spectrophotometry. Abdelmageed, OH; Mohamed, Ael-M; Refaat, IH, ) | 0.13 |
| " Depending on the intended indication and dosing regimen, PPL can delay or stop development of a compound in the drug discovery process." | ( Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Gehlhaar, D; Greene, N; Johnson, TO; Pelletier, DJ; Tilloy-Ellul, A, ) | 0.13 |
| " The symmetric or balanced assays (2 x 2) as well as those with interpolation in standard curve (5 x 1) are the main designs used in the dosage of antibiotics." | ( Validation of erythromycin microbiological assay using an alternative experimental design. Kaneko, TM; Lourenço, FR; Pinto, Tde J, ) | 0.49 |
| "In a randomized, double-blind design, 106 patients were randomized into four dosing regimens (22 to placebo and 21 each to mitemcinal 10 mg, 20 mg, 30 mg bid or 20 mg tid) for 28 days." | ( Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesis - a randomized, multicentre, placebo-controlled study. Cynshi, O; McCallum, RW, 2007) | 0.34 |
| ") routes at a dosage of 10 mg/kg." | ( Pharmacokinetics and mammary residual depletion of erythromycin in healthy lactating ewes. Abd El-Aty, AM; Goudah, A; Sher Shah, S; Shim, JH; Shin, HC, 2007) | 0.59 |
| " Cisapride (1, 3 and 10 mg/kg) caused non-significant increases in the indices of gastric emptying, with roughly bell-shaped dose-response curves." | ( Oral mitemcinal (GM-611), an erythromycin-derived prokinetic, accelerates normal and experimentally delayed gastric emptying in conscious dogs. Akima, M; Itoh, Z; Kamei, K; Koga, H; Omura, S; Onoma, M; Ozaki, K; Takanashi, H; Yogo, K, 2008) | 0.64 |
| "Administration of erythromycin, tilmicosin, and tylosin at the label dosage increased abomasal emptying rate in calves." | ( Effect of parenteral administration of erythromycin, tilmicosin, and tylosin on abomasal emptying rate in suckling calves. Constable, PD; Nouri, M, 2007) | 0.94 |
| "Commonly used dosage protocols for antimicrobial agents may alter the rate of gastric emptying." | ( Effect of erythromycin and gentamicin on abomasal emptying rate in suckling calves. Constable, PD; Hajikolaee, MR; Nouri, M; Omidi, A, ) | 0.53 |
| " They also indicate that the increased incidence of lymphomas was based on a non-genotoxic effect with a threshold dose-response and that the tumorigenesis was based on the strain or species specificity of background factors." | ( Assessment of the carcinogenic potential of mitemcinal (GM-611): increased incidence of malignant lymphoma in a rat carcinogenicity study. Fujii, E; Itoh, Z; Kato, A; Kimura, K; Mizoguchi, K; Omura, S; Suzuki, M; Takanashi, H, 2008) | 0.35 |
| " These findings suggest that differential affinities for solute carriers should be considered when selecting an appropriate phenotypic probe to allow tailored dosing of pharmaceuticals that are CYP3A4 substrates." | ( Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. Baker, SD; Franke, RM; Mathijssen, RH; Schuetz, EG; Sparreboom, A, 2008) | 0.35 |
| " Cohorts of six patients were recruited sequentially to one of three fixed starting dose groups-2, 4, or 7 mg, with drug administered by fixed-dose rather than dosing by body surface area." | ( A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. Cendros, JM; Evans, TR; Falk, S; Graham, JS; Samuel, LM, 2009) | 0.35 |
| " Alternative oral dosing schedules of diflomotecan have been shown to display a more predictable PK/PD and safety profile and should be selected for further evaluation in Phase II clinical trials." | ( A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. Cendros, JM; Evans, TR; Falk, S; Graham, JS; Samuel, LM, 2009) | 0.35 |
| ", 100-, 200-, 400-, 800-, or 1,200-mg dosing groups) consisting of eight subjects (six active and two placebo) each." | ( Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. Jiang, LJ; Or, YS; Wang, M, 2009) | 0.35 |
| " Based on thin layer chromatography findings, non-conformities in product identity and dosage involved mainly erythromycin (45%) followed by amoxicillin and ciprofloxacin (22% each)." | ( [Quality control of antibiotics used in Senegal]. Diop, A; Diop, YM; Fall, M; Mbaye, G; Ndiaye, B; Sarr, SO, 2009) | 0.56 |
| " Previous concomitant dosing studies in rats using rifamycin SV, a general organic anion-transporting polypeptide (OATP) inhibitor, suggested that the high oral absorption of azithromycin and clarithromycin may be caused by facilitative uptake by intestinal Oatps." | ( Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides. Davis, CB; Dawson, PA; Garver, E; Han, C; Haywood, J; Lan, T; Rao, A, 2009) | 0.35 |
| " She was receiving a weekly maintenance dosage of 14 mg." | ( Elevated International Normalized Ratio associated with concurrent use of ophthalmic erythromycin and warfarin. Gerschutz, GP; Hoffmann, TK; Malone, PM; Parker, DL; Tucker, MA, 2010) | 0.58 |
| " Route-randomized, two-way crossover pharmacokinetic studies of ER were conducted in 12 ESRD patients and 12 healthy controls after oral (250 mg) and intravenous (125 mg) dosing with ER." | ( Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Benet, LZ; Frassetto, LA; Huang, Y; Sun, H, 2010) | 0.62 |
| " Our patients were divided in two groups, erythromycin in doses of 200 mg four times per day was given to the first group (51 patients) over the first 3 months of the study and in the second group we used placebo with the same dosage and schedule (53 patients)." | ( A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritis. Ardalan, MR; Ghojazadeh, M; Molaeefard, M; Moloudi, R; Noshad, H; Sadreddini, S, 2009) | 0.84 |
| " More specifically, the heterologous proteins responsible for 6dEB production were varied by adjusting their respective gene dosage levels." | ( Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. Boghigian, B; Pfeifer, BA; Wang, Y; Zhang, H, 2009) | 0.35 |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | ( FDA-approved drug labeling for the study of drug-induced liver injury. Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) | 0.37 |
| " A range of antibiotic effectiveness was displayed in this cell association assay, providing data that may be considered in addition to traditional testing when determining therapeutic dosing regimens." | ( A novel cell-associated protection assay demonstrates the ability of certain antibiotics to protect ocular surface cell lines from subsequent clinical Staphylococcus aureus challenge. Bilonick, RA; Kowalski, RP; Ling, Y; Mah, FS; Romanowski, EG; Shanks, RM; Wingard, JB, 2011) | 0.37 |
| " The selection and magnitude of the PK/PD index were, however, shown to be sensitive to differences in PK in subpopulations, uncertainty in MICs, and investigated dosing intervals." | ( Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization. Cars, O; Friberg, LE; Nielsen, EI, 2011) | 0.37 |
| " Oral erythromycin was started at a dosage of 30 to 50 mg/kg per day in three to four divided dosages for 1 to 4 months." | ( Childhood pityriasis lichenoides and oral erythromycin. Ersoy-Evans, S; Hapa, A; Karaduman, A, ) | 0.88 |
| " We speculate that appropriate antibiotic selection and dosing are required for effective treatment of Ureaplasma sepsis in neonates, and this model could be used to further evaluate these relationships." | ( Appropriate antibiotic therapy improves Ureaplasma sepsis outcome in the neonatal mouse. Kong, L; Leeming, AH; Weisman, LE, 2012) | 0.38 |
| " Recognition of the importance of transporter-enzyme interplay, in which genetic variants of drug uptake transporters can change drug metabolism when the enzymes are unchanged, is an important advance in predicting appropriate drug dosage regimens for the individual patient." | ( A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates. Benet, LZ, 2012) | 0.38 |
| " Only clarithromycin and the combination clarithromycin-rifampin were predicted to achieve concentrations in bronchoalveolar cells and pulmonary epithelial lining fluid above the MPC for the entire dosing interval." | ( Mutant prevention concentration and mutant selection window for 10 antimicrobial agents against Rhodococcus equi. Berghaus, LJ; Giguère, S; Guldbech, K, 2013) | 0.39 |
| "The aim of this study is to evaluate the frequency of dosing topical antibiotics as monotherapy in the treatment of acne vulgaris, and physician specialty prescribing these medications." | ( Topical antibiotic monotherapy prescribing practices in acne vulgaris. Davis, SA; Feldman, SR; Fleischer, AB; Hoover, WD, 2014) | 0.4 |
| " pneumoniae strains tested were penicillin resistant, standard penicillin dosing for pneumonia may be insufficient given the observed range of pneumococcal penicillin MICs." | ( Antimicrobial susceptibility of Streptococcus pneumoniae in adult patients with pneumococcal pneumonia in an urban hospital in Mozambique. Beishuizen, SJ; Bos, JC; Cossa, EO; Gomonda, Edos S; Macome, AC; Madeira, GC; Prins, JM; Schultsz, C; van Steenwijk, RP, 2014) | 0.4 |
| " Parallel batch reactors were operated for six days, with increasing erythromycin dosing in the range of 1-1000 mg L(-1)." | ( Acute effect of erythromycin on metabolic transformations of volatile fatty acid mixture under anaerobic conditions. Cetecioglu, Z; Ince, B; Ince, O; Orhon, D, 2015) | 1 |
| " These novel compounds can significantly reduce the dosage of β-lactam antibiotics against MRSA, while this synergistic effect is different from the combination of β-lactams and β-lactamase inhibitors." | ( New erythromycin derivatives enhance β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Chen, D; Dong, X; Ge, H; He, M; Li, J; Li, Z; Lin, H; Shen, S; Ye, RD, 2015) | 0.98 |
| " It is a major determinant of half-life and dosing frequency of a drug." | ( Volume of Distribution in Drug Design. Beaumont, K; Di, L; Maurer, TS; Smith, DA, 2015) | 0.42 |
| "For the analysis of erythromycin (ER) in topical pharmaceutical forms we developed a high performance liquid chromatography dosage method (HPLC) greatly improved over the method formalized by the European Pharmacopoeia 5th ed." | ( DEVELOPMENT AND VALIDATION OF THE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE QUANTITATIVE DETERMINATION OF ERYTHROMYCIN IN DERMO-PREPARATIONS. Ghiciuc, CM; Hortolomei, M; Ochiuz, L; Petrescu, DC; Popovici, I; Timofte, D, ) | 0.66 |
| " The DDI risk for cobimetinib with other CYP3A4 inhibitors and inducers needs to be assessed in order to provide dosing instructions." | ( Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. Budha, NR; Chen, Y; Dresser, M; Eppler, S; Ji, T; Jin, JY; Musib, L, 2016) | 0.43 |
| "This study demonstrates the value of using PBPK simulation to assess the clinical DDI risk inorder to provide dosing instructions with other CYP3A4 perpetrators." | ( Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation. Budha, NR; Chen, Y; Dresser, M; Eppler, S; Ji, T; Jin, JY; Musib, L, 2016) | 0.43 |
| " The novel topical application has many advantages like averting the GI-irritation, preventing the metabolism of drugs in the liver and increasing the bioavailability of the drug over the conventional dosage forms." | ( Topical Delivery of Erythromycin Through Cubosomes for Acne. Bhargava, S; Jain, A; Jain, P; Jain, R; Jain, S; Khan, S, 2018) | 0.8 |
| "This was an open-label, multicenter, phase-1 study to evaluate the drug interaction between steady-state ibrutinib and moderate (erythromycin) and strong (voriconazole) CYP3A inhibitors in patients with B-cell malignancies and to confirm dosing recommendations." | ( A drug-drug interaction study of ibrutinib with moderate/strong CYP3A inhibitors in patients with B-cell malignancies. Chauhan, V; Córdoba, R; de Jong, J; De Wilde, S; de Zwart, L; Hellemans, P; Jiao, J; Manikhas, G; Masterson, T; Myasnikov, A; Osmanov, D; Ouellet, D; Panizo, C; Patricia, D; Snoeys, J; Sukbuntherng, J, 2018) | 0.69 |
| " Propagation velocity started returning toward baseline values after approximately 21-30 min for the 3 mg/kg dosage and after 31-40 min for a dosage of 6 mg/kg." | ( Noninvasive Magnetogastrography Detects Erythromycin-Induced Effects on the Gastric Slow Wave. Bradshaw, LA; Cheng, LK; Hawrami, D; Muszynski, ND; Olson, JD; Somarajan, S, 2019) | 0.78 |
| "The objective of the study was to evaluate whether there are differences in the latency from preterm premature rupture of membranes to delivery in patients treated with different dosing regimens of azithromycin vs erythromycin." | ( Azithromycin vs erythromycin for the management of preterm premature rupture of membranes. Bachilova, S; Berghella, V; Heidari, P; Hoffman, MK; Navathe, R; Roman, A; Schoen, CN; Smith, S; Tepper, J; Visintainer, P; Ward, A, 2019) | 1.05 |
| "There was no difference in latency to delivery, incidence of chorioamnionitis, or neonatal outcomes when comparing different dosing regimens of the azithromycin with erythromycin, with the exception of respiratory distress syndrome being more common in the 5 day azithromycin group." | ( Azithromycin vs erythromycin for the management of preterm premature rupture of membranes. Bachilova, S; Berghella, V; Heidari, P; Hoffman, MK; Navathe, R; Roman, A; Schoen, CN; Smith, S; Tepper, J; Visintainer, P; Ward, A, 2019) | 1.06 |
| " The experimental results showed that the ERY content and ARGs abundance decreased with increase of the absorbed dose and PMS dosage and gamma irradiation was more effective to abate ARGs from the EryF wastes." | ( Degradation of antibiotics and antibiotic resistance genes in erythromycin fermentation residues using radiation coupled with peroxymonosulfate oxidation. Chen, D; Chu, L; Shen, Y; Wang, J; Yang, Z, 2019) | 0.75 |
| "03) mL, analgesic dosage was (145." | ( The value of erythromycin pleurodesis in treatment of spontaneous pneumothorax. Du, G; Gao, X; Han, K; Ma, N; Meng, Q; Sun, Z, 2019) | 0.88 |
| " Most recommendations for drug usage and dosage are based on collective clinical experience." | ( Ultrasonographic assessment of the effect of metoclopramide, erythromycin, and exenatide on solid-phase gastric emptying in healthy cats. Fletcher, JM; Gaschen, FP; Gaschen, L; Husnik, R, 2020) | 0.8 |
| " The aims of this study were to develop and evaluate population pharmacokinetic (PPK) models of caffeine in preterm infants through comprehensive screening of covariates and then to propose model-informed precision dosing of caffeine for this population." | ( Population pharmacokinetic modeling of caffeine in preterm infants with apnea of prematurity: New findings from concomitant erythromycin and AHR genetic polymorphisms. Chen, F; Cheng, R; Dai, HR; Ding, XS; Guo, HL; He, X; Hu, YH; Jiao, Z; Liu, Y; Lu, KY; Xu, J, 2022) | 0.93 |
| "Erythromycin preconditioning reduced the volume of cerebral infarction after induction of cerebral ischemia, showing a U-shaped, dose-response relationship, and the cerebral infarction volume significantly decreased in the 20-, 35-, and 50-mg/kg erythromycin preconditioning groups (P < ." | ( Protective Effect of Erythromycin Pre-adaptation on Focal Cerebral Ischemia in Rats and its Changes in TNF-α and nNOS. Gou, D; Han, S; Li, G; Lu, W; Si, M; Yang, R, 2023) | 2.67 |
| " There is no oral formulation with dosage and/or excipients adapted for these high-risk patients." | ( Low-dose erythromycin in pediatrics: Formulation and stability of 20 mg hard gelatin capsules. Benech, A; Bertault-Peres, P; Castera Ducros, C; Curti, C; Jean, C; Lamy, E; Primas, N; Thevin, P; Vanelle, P, 2023) | 1.33 |
| " The presence of hormesis may challenge the current concept of dose-response adopted in chemical risk assessment." | ( Mechanistic insights into hormesis induced by erythromycin in the marine alga Thalassiosira weissflogii. Chen, H; Guo, J; Kong, RYC; Liu, W; Lv, R; Mo, J; Qin, X; Shi, J; Wu, X; Wu, Y; Yan, N, 2023) | 1.17 |
| Class | Description |
|---|---|
| erythromycin | Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus). |
| cyclic ketone | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| Erythromycin Action Pathway | 1 | 4 |
| Drug induction of bile acid pathway | 0 | 25 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 20.9030 | 0.0447 | 17.8581 | 100.0000 | AID485294; AID485341 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 70.7946 | 14.1254 | 24.0613 | 39.8107 | AID504937 |
| TDP1 protein | Homo sapiens (human) | Potency | 3.6626 | 0.0008 | 11.3822 | 44.6684 | AID686979 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 15.7839 | 0.0007 | 14.5928 | 83.7951 | AID1259392 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 41.9965 | 0.0015 | 30.6073 | 15,848.9004 | AID1224849 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 16.9440 | 0.0002 | 29.3054 | 16,493.5996 | AID743075; AID743079 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 8.3794 | 0.0003 | 23.4451 | 159.6830 | AID743065 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 21.1923 | 0.1683 | 16.4040 | 67.0158 | AID720504 |
| geminin | Homo sapiens (human) | Potency | 1.6360 | 0.0046 | 11.3741 | 33.4983 | AID624297 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 100.0000 | 6.3096 | 60.2008 | 112.2020 | AID720707 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID150753 | Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID285849 | Antimicrobial activity against tetracyclin-resistant Streptococcus pyogenes C-105 transconjugated with erm(B) and tet(M) genes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene. |
| AID323003 | Antibacterial activity against drug-resistant Propionibacterium acnes P425:1 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID573131 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID694205 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 8325-4 by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22 | Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives. |
| AID584996 | Antibacterial activity against methicillin-resistant Staphylococcus aureus M05/0060 harboring cfr-encoding conjugative pSCFS7 and fexA by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. |
| AID767512 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus MSSA-1 by standard dilution assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18 | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. |
| AID135344 | Plasma concentration in mice was determined by subcutaneous administration, 20 mg/kg at 20 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1241211 | Binding affinity to 5'-FAM-pre-miR-373 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID573124 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID168683 | Fluid concentration in lung tissue was determined in rats at 0.5 h | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID571264 | Antimicrobial activity against Campylobacter jejuni DC23 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID369227 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID548525 | Antimicrobial activity against Oxacillin-susceptible Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID323026 | Antibacterial activity against Corynebacterium jeikeium after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID574938 | Antimicrobial activity against compound pretreated Staphylococcus epidermidis biofilms | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID681119 | TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID279889 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 7.8 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID581472 | Inhibition of poly(U)-dependent synthesis of poly(Phe) using Escherichia coli K-12 70S ribosome at 20 uM after 1 hr by liquid scintillation counting | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID278524 | Antimicrobial activity against Bifidobacterium bifidum BB12 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID520085 | Antimicrobial activity against acrAB-deficient Escherichia coli TG1 harboring plasmid pEX19Gm by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID112490 | In Vivo evaluation for its effective dose against Streptococcus pneumoniae (030MV2 EryRc) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID768662 | Antibacterial activity against Propionibacterium acnes PCM 2400 assessed as growth inhibition after 48 hrs by microplate Alamar blue assay | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Synthesis of novel isothiazolopyridines and their in vitro evaluation against Mycobacterium and Propionibacterium acnes. |
| AID531566 | Antibacterial activity against Enterococcus faecium obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID278543 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID765061 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 | Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. |
| AID86119 | In vitro antibacterial activity against Haemophilus influenzae GYR1435 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID508378 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID534341 | Antimicrobial activity against Burkholderia pseudomallei Bp227 harboring deleted (bpeAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID524550 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bactericidal at 8 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID545044 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ078 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID1211886 | Unbound biliary clearance in iv dosed dog | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID561752 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID428139 | Antimicrobial activity against wild-type Streptococcus pneumoniae PC13 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID584115 | Antibacterial activity against Escherichia coli KAM32 harboring pSP72 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID584122 | Antimicrobial activity against Staphylococcus aureus RN4220 by CLSI M31-A3 method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. |
| AID404949 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate assessed as percent resistant isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID187378 | Plasma concentration in rats was determined by oral administration, 20 mg/kg at 4 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1594137 | Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analysis | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID562603 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID535344 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID562408 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1159105 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 15 mg for 24 hrs at 37 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID564808 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus simulans after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID565735 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group C clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID325006 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 237 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID564810 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID528724 | Antibacterial activity against Streptococcus oralis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID531562 | Antibacterial activity against coagulase-negative Staphylococcus warneri obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1227265 | Inhibition of Serratia marcescens chitinase ChiB assessed as reduction in chitinolytic activity using 4MU-(GlcNAc)2 substrate by fluorescence based assay | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12 | Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase. |
| AID533852 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium abscessus after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID574929 | Enhancement of biofilm formation Staphylococcus epidermidis SW120 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID279887 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 31.3 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID404937 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID278571 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID318677 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 6303 in mouse pulmonary infection model assessed as survival at 25 mg/kg, ip twice daily for 3 days | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID562377 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus agalactiae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID571478 | Antimicrobial activity against Campylobacter jejuni JL292 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID562224 | Antimicrobial activity against Desulfovibrio piger by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID325008 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 426 isolate with erm(B) resistance gene from patient sinuitis by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID1546172 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as zone of inhibition at 100 ug/ml after 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID528716 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID444053 | Renal clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID278568 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID278573 | Antimicrobial activity against Rhodococcus equi ATCC 6939 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID532980 | Antibacterial activity against Escherichia coli DH5alpha in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID548795 | Antimicrobial activity against Oxacillin-susceptible coagulase-negative Staphylococcus assessed as percent resistant isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID519671 | Toxicity in normal human epidermal keratinocytes assessed as effect on cell viability at 100 uM after 72 hrs by colorimetric assay | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. |
| AID554544 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC720 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID554548 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC720 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID767513 | Antibacterial activity against Streptococcus pneumoniae 943 by standard dilution assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18 | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. |
| AID245693 | Minimum inhibitory concentration of the compound against 3 erythromycin-susceptible Streptococcus pneumoniae OC4051 with an erm(B)-ribosomal methylase-mediated resistance was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID326016 | Antimicrobial activity against Campylobacter jejuni S3BE2-2 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID245131 | Minimum inhibitory concentration against Streptococcus pyogenes EES61 (erythromycin-susceptible strain) | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10 | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. |
| AID1177386 | Antibacterial activity against Bacillus subtilis | 2014 | Journal of natural products, Aug-22, Volume: 77, Issue:8 | Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete. |
| AID584337 | Antibacterial activity against tolC deficient Escherichia coli GD100 absence of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID530050 | Antimicrobial activity against Staphylococcus aureus 286607-R1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID576334 | Antimicrobial activity against Chlamydia trachomatis serovar D infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID244956 | Minimum inhibitory concentration against Staphylococcus pneumoniae OC9132 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID562399 | Antimicrobial activity against Streptococcus Group F clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID197886 | In vivo efficacy against Staphylococcus aureus WCUH29 in a Groin Abscess infection in rats at a dose of 50 mg/kg; log10 cfu | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID559859 | Antimicrobial activity against Streptococcus agalactiae clinical isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients, ranging from newborns to the elderly, with invasive infections. |
| AID135343 | Plasma concentration in mice was determined by subcutaneous administration, 20 mg/kg at 1 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID263387 | Antibacterial activity against Staphylococcus aureus Smith OC4172 in presence of 50% mouse serum | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID411672 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes 19615 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID369443 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID113990 | Effective dose against mice infected with streptococcus pyogenes after peroral administration (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID565040 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID365666 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 13709 Smith after 24 hrs by twofold serial dilution method | 2008 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16 | Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment. |
| AID565730 | Antimicrobial activity against Streptococcus Group F clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID113494 | ED50 value was measured by po administration against streptococcus pneumoniae infection in mice (in vivo, in experiment 1) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID567568 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring pBS-01multiple resistance gene cfr and phenolic resistance gene fexA obtained from swine feces | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. |
| AID58287 | Evaluated for gastrointestinal motor stimulating (GMS) activity in dog estimated in vivo by 2 x 2 points parallel line assay. Activity of EM-A was assumed to be 1 | 1987 | Journal of medicinal chemistry, Nov, Volume: 30, Issue:11 | Macrolides with gastrointestinal motor stimulating activity. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID326069 | Reduction of pneumolysin production in Streptococcus pneumoniae NMU112 lysates at 5 ug/mL after 12 hrs by Western blot relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID531567 | Antibacterial activity against Streptococcus agalactiae obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1687314 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID574913 | Enhancement of biofilm formation Staphylococcus epidermidis SW058 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID681003 | TP_TRANSPORTER: inhibition of Glutarate uptake (Glutarate: 5 uM, Erythromycin: 1000 uM) in Xenopus laevis oocytes | 2002 | Molecular pharmacology, Jul, Volume: 62, Issue:1 | Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. |
| AID424330 | Antimicrobial activity against Dialister invisus assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID404953 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. assessed as percent resistant isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID534082 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID516800 | Inhibition of human ERG expressed in HEK cells at 30 uM | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19 | 9-Dihydroerythromycins as non-antibiotic motilin receptor agonists. |
| AID168832 | Fluid concentration in urine was determined in rats at 0.5 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID528727 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID554868 | Antimicrobial activity against Streptococcus pneumoniae serotype 23F ST 81 harboring ERY-resistant mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID1555433 | Antibacterial activity against Klebsiella pneumoniae assessed as diameter of zone of inhibition at 15 ug/disc by disc diffusion method | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper. |
| AID1555432 | Antibacterial activity against Staphylococcus aureus assessed as diameter of zone of inhibition at 15 ug/disc by disc diffusion method | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper. |
| AID323013 | Antibacterial activity against drug-resistant Propionibacterium acnes P:413 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID508369 | Antibacterial activity against Streptococcus pneumoniae harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID554978 | Antimicrobial activity against Staphylococcus aureus UCN18 with A2059G mutation in rrl allele | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID326015 | Antimicrobial activity against Campylobacter jejuni S3BE2-2 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID569033 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae AB11 expressing the erm and mef gene by broth microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. |
| AID565019 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID573125 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1217729 | Intrinsic clearance for reactive metabolites formation assessed as summation of [3H]GSH adduct formation rate-based reactive metabolites formation and cytochrome P450 (unknown origin) inactivation rate-based reactive metabolites formation | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID396033 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pBGS18 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID573128 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID529874 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring pAT392 containing rdmC-like gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID680907 | TP_TRANSPORTER: cell accumulation of doxorubicin in the presence of Erythromycin at a concentration of 1mM in K562/ADR cells | 2004 | European journal of pharmacology, Jan-26, Volume: 484, Issue:2-3 | Azithromycin reverses anticancer drug resistance and modifies hepatobiliary excretion of doxorubicin in rats. |
| AID533855 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium fortuitum after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID279894 | Attenuation of THP1 cell invasion by Burkholderia pseudomallei KHW at 8 ug/ml in presence of 500 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID571257 | Antimicrobial activity against Campylobacter jejuni DC16 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID263389 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4051 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID424422 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus HIP15178 isolated from patients surgical wound by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID554673 | Antimicrobial activity against Streptococcus pneumoniae serotype 9V ST 156 harboring ERY-resistant erm(B) or mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID261790 | Antibacterial activity against macrolide resistant Staphylococcus aureus ATCC 141541 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID278535 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID718275 | Antimicrobial activity against Micrococcus luteus | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID206331 | Minimum inhibitory activity against Staphylococcus aureus ATCC 6538P | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6 | Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A. |
| AID586051 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type 1 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID598143 | Antimicrobial activity against Micrococcus luteus ATCC 21212 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID511432 | Antimicrobial activity against Clostridium perfringens LFM1 assessed as resistance breakpoint by DIN-standardized microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID575944 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID586067 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB gene expressing Enterococcus faecium isolate CS106 containing streptogramin A resistance genes vatG and vgaD isolated from poultry stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID1870143 | Antibacterial activity against wild type Staphylococcus aureus 4862/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID357637 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9 | A new naphthopyrone derivative from Cassia quinquangulata and structural revision of quinquangulin and its glycosides. |
| AID428292 | Antimicrobial activity against Acinetobacter baumannii BM4579 expressing deltaadeIJK genes isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID396002 | Antimicrobial activity against Mycoplasma putrefaciens KS1 after 24 hrs by twofold serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibilities of Mycoplasma putrefaciens field isolates. |
| AID1261120 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 29213 by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID571501 | Antimicrobial activity against Campylobacter jejuni DC2 infected in 15 days old chicken by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID574716 | Upregulation of pyrR gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID523015 | Activity at macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay in presence of GTP | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID187397 | Plasma concentration in rats was determined by subcutaneous administration, 20 mg/kg at 8 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID531569 | Antibacterial activity against Streptococcus sp. 'group C' obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID530237 | Antimicrobial activity against wild-type Mycobacterium smegmatis SMR5 by microplate Alamar blue assay | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis. |
| AID41412 | In vitro antimicrobial activity against anaerobic bacteria bacteroides melaninogenicus 2736 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID564820 | Bactericidal activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID574949 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID278856 | Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID323032 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID574951 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID721790 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 assessed as growth inhibition after 24 hrs by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes. |
| AID573157 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID588215 | FDA HLAED, alkaline phosphatase increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID559771 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 4sy39 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID681132 | TP_TRANSPORTER: ATP hydrolysis in MDR1-expressing Sf9 cells | 2001 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 299, Issue:2 | Rational use of in vitro P-glycoprotein assays in drug discovery. |
| AID718413 | Antibacterial activity against log-phase vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as growth inhibition after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents. |
| AID534316 | Antimicrobial activity against wild-type Streptococcus pneumoniae GA17457 expressing PmefE-lacZ gene induced by pretreatment with 200 ug/ml of LL-37 peptide for 1 hr by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID516161 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates assessed as resistant isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID278557 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID573388 | Antibacterial activity against Pasteurella multocida by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID210387 | In vitro antibacterial activity against Streptococcus pneumoniae strain 5649. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID571506 | Antimicrobial activity against tylosin pre-exposed compound-resistant Campylobacter jejuni | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1241206 | Inhibition of pre-miR-17 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID368421 | Antimicrobial activity against Escherichia coli KAM32 pSTV28 containing chloramphenicol-resistant vector by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID508386 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID534338 | Antimicrobial activity against Burkholderia pseudomallei Bp250 harboring mini-Tn7T-bpeA+B+ -oprB+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID565753 | Antimicrobial activity against oxacillin-resistant Staphylococcus haemolyticus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID210208 | In vitro antibacterial activity against 5979 strain of Streptococcus pneumoniae | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID168696 | Fluid concentration in serum was determined in rats at 4 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID326012 | Antimicrobial activity against Campylobacter coli AW-II-35 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID571475 | Antimicrobial activity against Campylobacter jejuni JL289 harboring 23S rRNA A2074C mutant selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1502711 | Antimycobacterial activity against Mycobacterium avium isolate MAV2 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID532676 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID573390 | Antibacterial activity against Pasteurella multocida assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID573143 | Antibacterial activity against penicillin-susceptible Streptococcus viridans by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID706058 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 49951 incubated for 24 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. |
| AID528723 | Antibacterial activity against Streptococcus constellatus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID318671 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae KT2524 in mouse dosed iv 1 hr after infection | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID1221981 | Efflux ratio of permeability from apical to basolateral over basolateral to apical side of MDCK cells expressing BCRP | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID556349 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae ATCC 15531 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China. |
| AID562583 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1331161 | Antimicrobial activity against Escherichia coli ATCC 25922 after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID1573586 | Apparent permeability from apical to basolateral side in human Caco2 cells measured at 90 mins time interval by LC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors. |
| AID519329 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT04 carrying duplication in the carboxy-terminal region of L22 ribosomal protein | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID544282 | Antimicrobial activity against Enterococcus faecalis NKH12 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID206101 | In vitro antimicrobial activity against aerobic bacteria Streptococcus B 8 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID547196 | Antibacterial activity against Campylobacter coli assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea. |
| AID560511 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b5k3578 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID565007 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID574916 | Enhancement of biofilm formation Staphylococcus epidermidis SW085 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID279881 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 3.9 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID1240315 | Antibacterial activity against wild type Escherichia coli BW5328/pAH69 by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID565729 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group F clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID533664 | Antimicrobial activity against Staphylococcus aureus RN1024-tms | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID571492 | Antimicrobial activity against Campylobacter jejuni JL306 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID528728 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID534339 | Antimicrobial activity against Burkholderia pseudomallei 1026b after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID519140 | Antimicrobial activity against community-acquired methicillin resistant Staphylococcus aureus expressing PVL and mec type IV gene assessed as resistant strains by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. |
| AID245166 | Minimum inhibitory concentration against Haemophilus influenzae GYR1435 (erythromycin susceptible strain) | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10 | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. |
| AID424424 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus AIS2006032 isolated from patients foot wound by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID724769 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae A22072 expressing mef gene by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID66413 | In vitro inhibitory activity against enterococci EryRc (13) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID565761 | Antimicrobial activity against Staphylococcus aureus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1594364 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis NRS101 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID113502 | ED50 value was measured by sc administration against staphylococcus aureus infection in mice (in vivo, in experiment 3) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID571768 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-I626M mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID428295 | Antimicrobial activity against Acinetobacter baumannii BM4579 expressing adeIJK genes with pAT807 isolated from patient with urinary tract infection by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID531625 | Antimicrobial activity against Mycoplasma pneumoniae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. |
| AID244850 | Minimum inhibitory concentration against Streptococcus pneumoniae 5649 strain | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10 | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. |
| AID519139 | Antimicrobial activity against community-acquired methicillin resistant Staphylococcus aureus expressing PVL gene and mec type IV gene assessed as susceptible strains by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. |
| AID1447484 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-resistant Pseudomonas aeruginosa isolate 91433 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID573387 | Antibacterial activity against beta lactamase-positive Moraxella catarrhalis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID245079 | Minimum inhibitory concentration against Streptococcus pyogenes 930 (erythromycin-resistant strain) | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10 | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID573134 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID573389 | Antibacterial activity against Pasteurella multocida assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID534086 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID16043 | Serum protein binding ability was measured | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | A comparative NMR study between the macrolide antibiotic roxithromycin and erythromycin A with different biological properties. |
| AID1762630 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 by CLSI based microplate assay | |||
| AID396031 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pACYC184 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID528734 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus haemolyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID575080 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1474191 | Antibacterial activity against Enterobacter cloacae BAA-1154 after 18 to 22 hrs in absence of colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID554656 | Antimicrobial activity against Ureaplasma parvum isolate UHWJM after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID1221965 | Transporter substrate index of efflux ratio in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID562366 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group F clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID548254 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID564812 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID510749 | Antibacterial activity against Escherichia coli AG102MB harboring pP10-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID322996 | Antibacterial activity against drug-resistant Propionibacterium acnes EG13NS after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID409957 | Inhibition of bovine liver MAOA | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21 | Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
| AID586048 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type U1 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID531556 | Antibacterial activity against coagulase-negative Staphylococcus lugdunensis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID530581 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae isolate 6 with A2604G mutation by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID554967 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as accumulation of partially processed 23S rRNA in 30S, 40S and 50S fractions at 7 ug/ml after 1 hr by primer extension analysis at 37 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID531574 | Antibacterial activity against Aerococcus viridans obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID586070 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB gene expressing Enterococcus faecium isolate AS115 containing streptogramin A resistance genes vatG and vgaD isolated from poultry stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID557090 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method in presence of 0.1% alpha-1-acid glycoprotein | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID1240316 | Antibacterial activity against tolC-deficient Escherichia coli JW5503-1 by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID565732 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group G clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID548522 | Antimicrobial activity against Oxacillin-susceptible Staphylococcus aureus assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID565754 | Antimicrobial activity against oxacillin-susceptible Staphylococcus haemolyticus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1687310 | Antibacterial activity against Klebsiella pneumoniae ATCC 1706 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID531558 | Antibacterial activity against coagulase-negative Staphylococcus capitis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID543825 | Antimicrobial activity against Borrelia spielmanii isolate PAnz after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1901491 | Stability of the compound in simulated gastric fluid assessed as compound remaining measured after 120 mins by LC-MS/MS | 2022 | Journal of medicinal chemistry, 03-10, Volume: 65, Issue:5 | Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. |
| AID561738 | Antibacterial activity against Beta-hemolytic Streptococcus group A assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID575084 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID210247 | In vitro antibacterial activity against 930 strain of Streptococcus pyogenes | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID245427 | Minimum inhibitory concentration of the compound against erythromycin-susceptible Staphylococcus aureus Smith OC4172 was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID533858 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium alvei after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID369448 | Antimicrobial activity against Streptococcus viridans after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1532165 | Apparent permeability in human Caco2 cells | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility. |
| AID1221962 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID279883 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 500 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID678904 | TP_TRANSPORTER: increase in brain concentration in mdr1a(-/-) mouse | 1998 | Archives of biochemistry and biophysics, Feb-15, Volume: 350, Issue:2 | Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. |
| AID531571 | Antibacterial activity against Streptococcus constellatus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1739430 | Apparent permeability across apical to basolateral side in human Caco-2 cells at 10 uM incubated for 2 hrs LC-MS/MS analysis | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. |
| AID540239 | Phospholipidosis-positive literature compound observed in dog | |||
| AID724498 | Antibacterial activity against Salmonella typhimurium TA98 by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID530052 | Antimicrobial activity against Staphylococcus aureus RN4220 expressing gyrB D437N mutant gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID369444 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID638884 | Antibacterial activity against Streptococcus pneumoniae 3579 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1594373 | Antibacterial activity against Klebsiella pneumoniae ATCC BAA-1705 after 18 to 24 hrs in presence of colistin by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID1870159 | Antibacterial activity against wild type Staphylococcus aureus 78/CF assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID717680 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID548526 | Antimicrobial activity against Oxacillin-resistant Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID496819 | Antimicrobial activity against Plasmodium falciparum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID276735 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents. |
| AID373750 | Antimicrobial activity against mupirocin-resistant methicillin-resistant Staphylococcus aureus assessed as resistant rate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. |
| AID279872 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 3.9 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID143745 | Inhibition of N-acetylphenylalanine-tRNA peptide bond formation by puromycin reaction at 10E-5 M | 1989 | Journal of medicinal chemistry, Sep, Volume: 32, Issue:9 | Synthesis and biological activity of photoactive derivatives of erythromycin. |
| AID524555 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 assessed as bactericidal at 8 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID564822 | Bactericidal activity against methicillin-resistant Staphylococcus aureus after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID679459 | TP_TRANSPORTER: transepithelial transport (basal to apical) in Caco-2 cells | 1998 | European journal of pharmacology, Oct-09, Volume: 358, Issue:3 | Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. |
| AID1215350 | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by refined CYP450 IC50 s | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jun, Volume: 39, Issue:6 | A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors. |
| AID260150 | Inhibition of ribosome function in a coupled transcription and translational assay using Escherichia coli S30 extracts | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Design, synthesis, and biological evaluation of BODIPY-erythromycin probes for bacterial ribosomes. |
| AID510747 | Antibacterial activity against Escherichia coli AG102MB harboring pSport1-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID396001 | Antimicrobial activity against Mycoplasma putrefaciens Jordanian isolates after 24 hrs by twofold serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibilities of Mycoplasma putrefaciens field isolates. |
| AID540232 | Dose normalised AUC in monkey after po administration | 2005 | Xenobiotica; the fate of foreign compounds in biological systems, Feb, Volume: 35, Issue:2 | Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. |
| AID681128 | TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID521968 | Antibacterial activity against Campylobacter sp. assessed as resistance breakpoint by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID279880 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 7.8 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID1221964 | Transporter substrate index ratio of permeability from basolateral to apical side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID534419 | Antibacterial activity against Mycobacterium bovis BCG-Connaught | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics. |
| AID528701 | Antibacterial activity against Streptococcus viridans clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID54923 | Inhibition of human cytochrome P450 3A4 | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID278669 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 2514 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID508367 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID528729 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID261797 | Antibacterial activity against Haemophilus influenzae ATCC 49766 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID348710 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 33591 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID554543 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC719 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID571927 | Ratio of MIC for Escherichia coli K-12 3-AG300 harboring acrB::rpsLneo mutant gene to MIC for Escherichia coli K-12 3-AG300 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID283555 | Antimicrobial activity against Streptococcus pneumoniae R6 transformants | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID1331172 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID1525336 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS384 expressing MsrA by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID113503 | ED50 value was measured by sc administration against streptococcus pneumoniae infection in mice (in vivo, in experiment 1) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID523013 | Activity at macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay in presence of ATP | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID560519 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate zj07028 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID187393 | Plasma concentration in rats was determined by subcutaneous administration, 20 mg/kg at 4 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID283550 | Antimicrobial activity against Streptococcus pneumoniae BSF-11524 isolate with erm(B) and L4 mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID576325 | Antibacterial activity against 10'4 to 10'5 CFU methicillin-resistant Staphylococcus aureus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID565015 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus simulans after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID532220 | Antibacterial activity against macrolide-lincosamide-streptogramin B-negative, beta-lactamase-positive, methicillin-susceptible Staphylococcus aureus isolate 5 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID562220 | Antimicrobial activity against Desulfovibrio sp. by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID1870140 | Antibacterial activity against wild type Staphylococcus aureus 4557/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID278572 | Antimicrobial activity against Streptococcus pyogenes ATCC 19615 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID1241208 | Inhibition of pre-miR-21 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID559769 | Antimycobacterial activity against PknGMtb-deficient Mycobacterium tuberculosis H37Rv at 100 mg/l after 7 days by microscopy | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID638881 | Antibacterial activity against Streptococcus pneumoniae by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1870138 | Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 4968/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID598806 | Agonist activity at motilin receptor | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series. |
| AID542389 | Antimicrobial activity against Staphylococcus aureus RN4220 transformed with Staphylococcus aureus ST9 plasmid pSCFS3 carrying cfr and fexA genes | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID573141 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID554979 | Antimicrobial activity against Staphylococcus aureus UCN14 with A2058T mutation in rrl allele | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID278504 | Antibacterial activity against Pneumococcus CDC018 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID283569 | Effect on modulation in uptake of [3H]progesterone in Escherichia coli AG102MB | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID1474189 | Antibacterial activity against Acinetobacter baumanii ATCC 19606 after 18 to 22 hrs in absence of colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID278502 | Antibacterial activity against Pneumococcus CDC001 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID528737 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1210300 | Drug metabolism in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by conventional assay | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Aug, Volume: 40, Issue:8 | Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: identifying rate-limiting steps and role of passive processes. |
| AID561726 | Antibacterial activity against Enterococcus faecalis assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID532677 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as intermediate resistant isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID113500 | ED50 value was measured by sc administration against staphylococcus aureus infection in mice (in vivo, in experiment 1) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID263391 | Antibacterial activity against Haemophilus influenzae OC4882 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID573149 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID205874 | In vitro antimicrobial activity against aerobic bacteria Streptococcus epi 270 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID278508 | Antibacterial activity against Pneumococcus CDC063 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID576137 | Antibacterial activity against 10'4 to 10'5 CFU Streptococcus pyogenes after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID531555 | Antibacterial activity against coagulase-negative Staphylococcus haemolyticus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID524825 | Antibacterial activity against erythromycin susceptible Campylobacter sp. by agar plate dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID326051 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 7 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID544277 | Antimicrobial activity against Enterococcus faecalis NKH7 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID562579 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group C clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID565755 | Antimicrobial activity against Staphylococcus haemolyticus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID404935 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus isolate by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID424843 | Inhibition of ribosomal activity in erythromycin-resistant Propionibacterium acnes P95 with G2057A mutation in domain V of 23S rRNA assessed as luciferase production by transcriptional and translational assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID1687317 | Synergistic antibacterial activity against Pseudomonas aeruginosa ATCC 15442 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID1055342 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID519327 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT01 carrying duplication in the carboxy-terminal region of L22 ribosomal protein | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID530587 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae isolate 1006 with A2603G mutation by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID168678 | Fluid concentration in liver tissue was determined in rats at 2 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID528726 | Antibacterial activity against Streptococcus mitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID512005 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: a novel class of acylides. |
| AID588119 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID586076 | Antibacterial activity against quinupristin-dalfopristin resistant and vanA gene expressing Enterococcus faecium isolate GAV04 containing streptogramin A resistance genes vatG and vgaD isolated from chicken meat samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID574919 | Enhancement of biofilm formation Staphylococcus epidermidis SW126 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID362546 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 16 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID41266 | In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 1877 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID519138 | Antimicrobial activity against community-acquired methicillin resistant Staphylococcus aureus expressing PVL and mec type IV gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. |
| AID533881 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID576140 | Antibacterial activity against 10'4 to 10'5 CFU methicillin-susceptible coagulase-negative Staphylococcus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID396028 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID577442 | Antimicrobial activity against Staphylococcus aureus USA300 isolate harboring pSK41 plasmid assessed resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States. |
| AID562580 | Antimicrobial activity against Streptococcus Group C clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID571270 | Antimicrobial activity against Campylobacter jejuni DC29 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID127940 | Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 2 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID201245 | In Vitro antibacterial activity against Staphylococcus aureus 1775 (ermA-c strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID542599 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus C623 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID574551 | Decrease in delta toxin levels in Staphylococcus aureus Sanger 252 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID1221977 | Transporter substrate index of efflux ratio in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID545055 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate CC023 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID86127 | In vitro inhibitory activity against Haemophilus influenzae (351CB12) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID565008 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID318668 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith in mouse dosed iv 1 hr after infection | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID528735 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus capitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1055330 | Antibacterial activity against vancomycin-sensitive Enterococcus faecium 09-10 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID278501 | Antibacterial activity against Pneumococcus DAW86 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID396000 | Antimicrobial activity against Mycoplasma putrefaciens French isolates after 24 hrs by twofold serial dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro susceptibilities of Mycoplasma putrefaciens field isolates. |
| AID1542757 | Potentiation of erythromycin-induced antibacterial activity against Klebsiella pneumoniae ATCC 700603 assessed as concentration required to restore 2 ug/ml erythromycin activity measured after 18 hrs | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID573119 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID371533 | Increase in electric field stimulated contractile response in New Zealand White rabbit gastric antrum at 3 uM pre-incubated for 15 mins | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Identification of small molecule agonists of the motilin receptor. |
| AID529875 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring pAT392 containing mph(B) gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID573137 | Antibacterial activity against erythromycin-susceptible Streptococcus agalactiae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID424425 | Antibacterial activity against Enterococcus faecalis AIS2007003 isolated from patients rectum by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID531557 | Antibacterial activity against coagulase-negative Staphylococcus hominis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID724504 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 29213 by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID604043 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae AB11 expressing erm and mef gene by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Synthesis and antibacterial activity of novel 4″-O-benzimidazolyl clarithromycin derivatives. |
| AID1516028 | Antibacterial activity against Pseudomonas aeruginosa 25349 clinical isolate incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1591542 | Antibacterial activity against penicillin-resistant Staphylococcus aureus clinical isolate incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID388083 | Antifungal activity at Benjaminiella poitrasii | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID564821 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1237458 | Inhibition of bio-film formation of Klebsiella planticola MTCC 530 incubated for 24 hrs at 37 degC under static conditions by crystal violet staining method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID1055334 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID444052 | Hepatic clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID571249 | Antimicrobial activity against Campylobacter jejuni DC8 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID318655 | Antibacterial activity against Moraxella catarrhalis K1209 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID576136 | Antibacterial activity against 10'4 to 10'5 CFU Enterococcus faecalis after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID554970 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as retardation of 16S rRNA processing at 100 ug/ml after 1 hr by primer extension analysis at 37 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID285851 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes E-115 transconjugated with erm(B) and tet(M) genes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene. |
| AID520610 | Antimicrobial activity against Group D Enterococcus faecalis clinical isolate expressing erm(B) gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Prevalence of the erm(T) gene in clinical isolates of erythromycin-resistant group D Streptococcus and Enterococcus. |
| AID369446 | Antimicrobial activity against Streptococcus group A after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1594365 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae ATCC 700677 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID532984 | Antibacterial activity against Escherichia coli MG1655 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID554880 | Antimicrobial activity against Streptococcus pneumoniae serotype 6B ST 3249 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID520392 | Antibacterial activity against mef and erm(B) positive Streptococcus pneumoniae isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID326005 | Antimicrobial activity against Campylobacter jejuni S3B by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID533876 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID588209 | Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset | 2010 | Chemical research in toxicology, Jul-19, Volume: 23, Issue:7 | Developing structure-activity relationships for the prediction of hepatotoxicity. |
| AID531565 | Antibacterial activity against Enterococcus faecalis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID574954 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID260948 | Antibacterial activity against Mef(A) efflux pump containing Streptococcus pneumoniae OC4438 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID531559 | Antibacterial activity against coagulase-negative Staphylococcus saprophyticus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID565037 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID348712 | Antibacterial activity against MLSB-resistant Streptococcus pneumoniae 700906 expressing erm by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID208779 | In vitro antibacterial activity against macrolide-lincosamide-streptogramin resistant Streptococcus pneumoniae 700904 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. |
| AID562401 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group F clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID520087 | Antimicrobial activity against acrAB-deficient Escherichia coli TG1 harboring AheABC efflux pump by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID473928 | Antibacterial activity against penicillin intermediate-resistant Streptococcus pneumoniae isolate I1 by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8 | Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides. |
| AID680016 | TP_TRANSPORTER: inhibition of Fexofenadine uptake (Fexofenadine: 2 uM, Erythromycin: 100 uM) in Xenopus laevis oocytes | 1999 | Drug metabolism and disposition: the biological fate of chemicals, Aug, Volume: 27, Issue:8 | OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. |
| AID520868 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU28 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID1055340 | Antibacterial activity against methicillin-resistant Staphylococcus aureus R6101 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID645048 | Antibacterial activity against compound-resistant Streptococcus pyogenes 24 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID562361 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278673 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 5734 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID535342 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID347517 | Potentiation of electric field stimulated-rabbit gastric antrum contraction at 1 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID535638 | Antimicrobial activity against Group B streptococcus serotype VI R2 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID565036 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID588217 | FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID1870137 | Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 4561/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID157383 | In vitro antimicrobial activity against anaerobic bacteria peptostreptococcus intermedius 1264 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID1061909 | Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM after 90 mins by LC-MS/MS analysis | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1 | The synthesis of novel taxoids for oral administration. |
| AID66557 | In vitro inhibitory activity against enterococci EryRc (13) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID535340 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID112496 | In Vivo evaluation for its effective dose against Streptococcus pyogenes (02A1UC1) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID202100 | In Vitro antibacterial activity against Streptococcus pneumoniae 5979 (ermB strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID1516025 | Antibacterial activity against Escherichia coli 20411 clinical isolate incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID477411 | Antibacterial activity against MBX-1090-resistant Staphylococcus aureus isolate d20A1 after 16 to 20 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. |
| AID276839 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae OC9132 | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID576335 | Antimicrobial activity against Chlamydia trachomatis serovar E infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID533854 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium peregrinum after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID440236 | Inhibition of human ERG expressed in HEK cells at 300 uM | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety. |
| AID1778125 | Antimicrobial activity against Bacillus anthracis assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID547525 | Antimicrobial activity against Streptococcus constellatus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID1159112 | Antimicrobial activity against Proteus vulgaris ATCC 33420 assessed as zone of inhibition at 15 mg for 24 hrs at 37 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID543820 | Antimicrobial activity against Borrelia spielmanii isolate PMew after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID718415 | Antibacterial activity against log-phase methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents. |
| AID1525305 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID508373 | Antibacterial activity against Streptococcus pneumoniae harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID309828 | Antimicrobial activity against Staphylococcus aureus ISP217 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID1891816 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth measured after 18 hrs by resazurin dye based analysis | 2022 | Bioorganic & medicinal chemistry, 06-15, Volume: 64 | Valorisation of the diterpene podocarpic acid - Antibiotic and antibiotic enhancing activities of polyamine conjugates. |
| AID444057 | Fraction escaping hepatic elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID51134 | In vitro antimicrobial activity against anaerobic bacteria clostridium septicum 1128 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID521802 | Antimicrobial activity against Francisella tularensis subsp. tularensis after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | In vitro susceptibility of isolates of Francisella tularensis types A and B from North America. |
| AID1447479 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 100036 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID576139 | Antibacterial activity against 10'4 to 10'5 CFU Streptococcus pneumoniae after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID544828 | Antimicrobial activity against Staphylococcus epidermidis Xen 43 biofilm assessed as log10 CFU/cm'2 in bacterial count | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID569037 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes R2 by broth microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. |
| AID512007 | Antibacterial activity against erythromycin, methicillin-resistant Staphylococcus aureus A333 by broth microdilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: a novel class of acylides. |
| AID112358 | In Vivo evaluation for its effective dose against Staphylococcus aureus (011GO25 EryRi. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID1667634 | Antibacterial activity against Streptococcus pneumoniae ATCC BAA1663 | 2020 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9 | Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains. |
| AID1591545 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID543826 | Antimicrobial activity against Borrelia spielmanii isolate PMai after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID571447 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 by Etest method in presence of NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID531560 | Antibacterial activity against coagulase-negative Staphylococcus cohnii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID534107 | Antibacterial activity against TolC deficient Pasteurella multocida pm0527 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID564817 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus hominis after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID422467 | Antimicrobial activity against nontypeable Haemophilus influenzae isolate 2019 expressing GFP isolated from patient with COPD assessed as inhibition biofilm formation at 0.25 ug/mL after 2 days | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilms. |
| AID424768 | Antibacterial activity against penicillin-sensitive Streptococcus pneumoniae CL8002 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID1159115 | Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as zone of inhibition at 15 mgby disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID571437 | Antibacterial activity against Escherichia coli IH3080 by Etest method in presence of 1 ug/ml NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID150752 | Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID388086 | Antibacterial activity at Escherichia coli | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID365668 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by twofold serial dilution method | 2008 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16 | Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment. |
| AID285157 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent susceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID694206 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22 | Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives. |
| AID278546 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID508384 | Antibacterial activity against Streptococcus pyogenes harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID530547 | Induction of PtcaA::lacZ gene expression in Staphylococcus aureus SH1000 at 2.5 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials. |
| AID571482 | Antimicrobial activity against Campylobacter jejuni JL296 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID548527 | Antimicrobial activity against Oxacillin-susceptible coagulase-negative Staphylococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1211869 | Total biliary clearance in Wistar rat at 10 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID528738 | Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID168694 | Fluid concentration in serum was determined in rats at 1 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID528710 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1517581 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition incubated for 18 hrs by broth dilution method | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines. |
| AID368420 | Antimicrobial activity against Escherichia coli KAM32 pHPA containing mutated GyrA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID574908 | Enhancement of biofilm formation Staphylococcus epidermidis ATCC 35984 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID729398 | Antimicrobial activity against wild type Escherichia coli K1 after overnight incubation by checkerboard assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5 | Vectorization efforts to increase Gram-negative intracellular drug concentration: a case study on HldE-K inhibitors. |
| AID1237455 | Inhibition of bio-film formation of Staphylococcus aureus MLS16 MTCC 2940 incubated for 24 hrs at 37 degC under static conditions by crystal violet staining method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID554547 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC719 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID1240318 | Antibacterial activity against wild type Escherichia coli MC4100 by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID574931 | Antimicrobial activity against Staphylococcus epidermidis SW029 expressing icaA gene assessed as increased biofilm formation at 6 to 12 hrs by CLSM | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID604044 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Synthesis and antibacterial activity of novel 4″-O-benzimidazolyl clarithromycin derivatives. |
| AID658535 | Antibacterial activity against Staphylococcus aureus RN4220 overexpressing MsrA macrolide efflux protein after 24 hrs | 2012 | Journal of natural products, Mar-23, Volume: 75, Issue:3 | Antibacterial acylphloroglucinols from Hypericum olympicum. |
| AID326021 | Antimicrobial activity against Campylobacter jejuni S3BE4-3 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID562359 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID326070 | Reduction of pneumolysin production in Streptococcus pneumoniae NMU112 lysates at 10 ug/mL after 12 hrs by Western blot relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID424757 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus MB2865 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID547530 | Antimicrobial activity against Streptococcus intermedius obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% defr | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID584121 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ST398 isolate 11 containing apmA, erm(B), tet(L), tet(M), tet(K), dfrK, aadD, mecA, blaZ resistance genes by CLSI M31-A3 method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. |
| AID576344 | Bactericidal activity against Chlamydia trachomatis serovar F infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID532678 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates assessed as resistant isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID1326852 | Antibacterial activity against Escherichia coli MB2884 by broth microdilution technique | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | A Gestalt approach to Gram-negative entry. |
| AID428234 | Increase in erm(B) mRNA expression in Streptococcus pneumoniae P13 transformant harboring 136-bp deletion in erm(B) gene at 0.25 ug/ml by qRT-PCR relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID440232 | Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety. |
| AID279896 | Attenuation of THP1 cell invasion by Burkholderia pseudomallei KHW at 128 ug/ml | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID535568 | Antibacterial activity against Salmonella enterica subsp. enterica serovar Saintpaul harboring G235A mutation in rlpD gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro activity of azithromycin against nontyphoidal Salmonella enterica. |
| AID545053 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ372 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID369436 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID571767 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-M626I mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID278551 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID533860 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium porcinum after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID276848 | Antibacterial activity against Propionibacterium acnes | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID278477 | Antibacterial activity against Pneumococcus DAW2 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID574920 | Enhancement of biofilm formation Staphylococcus epidermidis SW015 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID245360 | Minimum inhibitory concentration of the compound against erythromycin-susceptible Streptococcus pneumoniae was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID206100 | In vitro antimicrobial activity against aerobic bacteria Streptococcus B 5 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID573155 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1596581 | Bactericidal activity against Klebsiella pneumoniae BAA-1706 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID261786 | Antibacterial activity against macrolide resistant Streptococcus pneumoniae ATCC 700906 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID571931 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-S623N mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID206934 | In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus X400 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID424840 | Displacement of [14C]ERY from ribosome in erythromycin-resistant Propionibacterium acnes P95 with G2057A mutation in domain V of 23S rRNA | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID323017 | Antibacterial activity against drug-resistant Propionibacterium acnes SW3CD after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID598140 | Antimicrobial activity against Staphylococcus aureus 8325 (pEP2104) by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID678717 | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID1870146 | Antibacterial activity against wild type Staphylococcus aureus 4460/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID1361122 | Bacteriostatic activity against Pseudomonas aeruginosa ATCC 15442 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID347519 | Potentiation of electric field stimulated-rabbit gastric antrum contraction at 0.1 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID127931 | Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 0.25 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID533662 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring vgaAv positive plasmid CU1 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID1159110 | Antimicrobial activity against Klebsiella pneumoniae ATCC 13882 assessed as zone of inhibition at 15 mg for 24 hrs at 37 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID1474197 | Antibacterial activity against Acinetobacter baumanii ATCC 19606 after 18 to 22 hrs in presence of 1/4 times MIC colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID322998 | Antibacterial activity against drug-resistant Propionibacterium acnes SW11 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID326065 | Effect on Campylobacter jejuni S3B mutant colonization at 8 ug/ml | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID83807 | In vitro antimicrobial activity against aerobic bacteria Haemophilus parainfluenzae 9796 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID717688 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 09O077 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID168668 | Fluid concentration in kidney tissue was determined in rats at 1 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID519326 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus RN4220 carrying rplD and rplV genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID276840 | Antibacterial activity against erythromycin resistant Staphylococcus haemolyticus OC3882 containing erm(C) | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID404947 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate assessed as percent resistant isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID340858 | Antimicrobial activity against wild type vancomycin-intermediate resistant Staphylococcus aureus Mu50 by microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. |
| AID285158 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID516162 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID260947 | Antibacterial activity against erm(B) ribosomal methylase gene containing Streptococcus pneumoniae OC4051 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID348711 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae 49619 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID576132 | Antibacterial activity against 10'4 to 10'5 CFU Haemophilus influenzae after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID534327 | Antimicrobial activity against Streptococcus pneumoniae XZ7042 expressing PmefE-lacZ gene induced by pretreatment with 200 ug/ml of LL-37 peptide for 1 hr by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID388082 | Antifungal activity at Cryptococcus neoformans | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID1055336 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID323035 | Antibacterial activity against Streptococcus equi subsp. zooepidemicus after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID325007 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 415 isolate with erm(B) resistance gene from patient blood by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID544523 | Antimicrobial activity against Borrelia afzelii isolate G600 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID574901 | Upregulation of sarA gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 24 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID575079 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID534328 | Antimicrobial activity against Streptococcus pneumoniae XZ7042 expressing PmefE-lacZ gene induced by pretreatment with 1 ug/ml of compound for 1 hr by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID279876 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 125 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID1573587 | Apparent permeability from basolateral to apical side in human Caco2 cells measured at 90 mins time interval by LC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors. |
| AID581470 | Binding affinity to Escherichia coli K-12 70S ribosome 23S rRNA assessed as protection against DMS-induced modification of 23S rRNA domain V at nucleotides A789 by primer extension analysis | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID322991 | Antibacterial activity against drug-resistant Propionibacterium acnes SW17 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID548533 | Antimicrobial activity against Beta-hemolytic Streptococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID283556 | Antimicrobial activity against Streptococcus pneumoniae R6 with L4 mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID326013 | Antimicrobial activity against Campylobacter coli AW-II-37 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID547659 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae 2860 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID533205 | Antimicrobial activity against Haemophilus influenzae clinical isolates assessed as susceptible isolates by PK/PD technique | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID206071 | In vitro inhibitory activity against Streptococci EryRi (98) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID285846 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes A-3 transconjugated with erm(B) and tet(M) genes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene. |
| AID545045 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ082 from patient bile by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID202103 | In vitro antibacterial activity against ATCC 6303 strain of Streptococcus pneumoniae | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID547194 | Antibacterial activity against Campylobacter coli by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea. |
| AID565016 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID560515 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 13b16 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID278481 | Antibacterial activity against Pneumococcus DAW12 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID202104 | In vitro minimum inhibitory concentration for antibacterial activity against erythromycin susceptible strain Streptococcus pneumoniae IID553 | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13 | Synthesis and antibacterial activity of a novel series of acylides: 3-O-(3-pyridyl)acetylerythromycin A derivatives. |
| AID724503 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID576112 | Antimicrobial activity against mecA-positive Staphylococcus sciuri harboring staphylococcus aureus mecA gene assessed as resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. |
| AID1594370 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID288353 | Antibacterial activity against Streptococcus pneumoniae-M after 24 hrs by microdilution method | 2007 | Bioorganic & medicinal chemistry, Jul-01, Volume: 15, Issue:13 | Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides. |
| AID206394 | Compound was tested for photoinhibition of Staphylococcus aureus(CIP 53156); Sensitive | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 | Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria. |
| AID245268 | Minimum inhibitory concentration against Staphylococcus aureus OC4172 in presence of mouse serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID369435 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID679928 | TP_TRANSPORTER: inhibition of Rhodamine 123 transepithelial transport (basal to apical) (R123: 5 uM, Erythromycin: 100 uM) in Caco-2 cells | 1998 | European journal of pharmacology, Oct-09, Volume: 358, Issue:3 | Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. |
| AID1447482 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate P262-101856 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID554870 | Antimicrobial activity against Streptococcus pneumoniae serotype 23F ST 3250 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID1055329 | Antibacterial activity against apramycin-resistant Micrococcus luteus ATCC 10240 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID452744 | Antibacterial activity against Escherichia coli MG1655 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1 | Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. |
| AID326028 | Antimicrobial activity against Campylobacter coli RN14BE4-3 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID574169 | Antibacterial activity against Escherichia coli MG1655 harboring plasmid pBR322 carrying blaTEM-1 and tetA(C) genes grown as planktonic cells after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. |
| AID1058368 | Antibiofilm activity against Staphylococcus aureus MLS-16 MTCC 2940 after 24 hrs by crystal violet assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID1055344 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID573152 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID565004 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID569031 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae B1 expressing the erm gene by broth microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. |
| AID557210 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent intermediate isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID206079 | In vitro inhibitory activity against Streptococci EryR (27) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID1058367 | Antibiofilm activity against Klebsiella planticola MTCC 530 after 24 hrs by crystal violet assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID278558 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID565810 | Antimicrobial activity against Neisseria meningitidis by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. |
| AID534321 | Antimicrobial activity against mefE-mel::aph3-positive Streptococcus pneumoniae XZ8009 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID534313 | Antimicrobial activity against wild-type Streptococcus pneumoniae GA17457 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID322995 | Antibacterial activity against drug-resistant Propionibacterium acnes EG7NS after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID531568 | Antibacterial activity against Streptococcus pyogenes obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID498361 | Antimicrobial activity against rifampin resistant Klebsiella pneumoniae 52deltaacrB containing isogenic acrB knockout assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. |
| AID318653 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium ATCC 19434 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID727097 | Antibacterial activity against Enterobacter aerogenes Ea294 harboring Ea289deltaacrB after 18 hrs by broth dilution method | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5 | Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant gram-negative bacteria. |
| AID428241 | Increase in dimethylation at position A2058 of 23S rRNA of Streptococcus pneumoniae isolate P1501016 at 0.25 ug/ml by phosphorimager scanning relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID532675 | Antimicrobial activity against ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. |
| AID1516020 | Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID244915 | Minimum inhibitory concentration against Haemophilus influenzae OC4482 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID68572 | Minimum inhibitory activity against Enterococcus faecium ATCC 8043 | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6 | Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A. |
| AID369447 | Antimicrobial activity against Streptococcus group B after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID279903 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 15.6 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID531630 | Antimicrobial activity against Ureaplasma urealyticum by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. |
| AID325443 | Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID369437 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID278488 | Antibacterial activity against Pneumococcus DAW26 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID404936 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus sp. by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID1901477 | Stability of the compound in simulated gastric fluid assessed as half life measured upto 120 mins by LC-MS/MS analysis | 2022 | Journal of medicinal chemistry, 03-10, Volume: 65, Issue:5 | Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. |
| AID1594140 | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID576341 | Antimicrobial activity against Chlamydia trachomatis serovar K infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID1685707 | Antimicrobial activity against Pseudomonas aeruginosa assessed as inhibition of bacterial growth incubated for overnight by CLSI method | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12 | Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. |
| AID573385 | Antibacterial activity against beta lactamase-positive Moraxella catarrhalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1176914 | Antibacterial activity against Pseudomonas aeruginosa assessed as growth inhibition after 24 hrs by microplate reader analysis | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Synthesis and anti-biofilm activities of dihydro-pyrrol-2-one derivatives on Pseudomonas aeruginosa. |
| AID276847 | Antibacterial activity against Staphylococcus epidermidis | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID537107 | Antibacterial activity against Chlamydia pneumoniae CV6 infected in human Hep2 cells assessed as minimal chlamydiocidal activity after 72 hrs by fluorescence assay | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. |
| AID150757 | P-gp activity was measured by a direct transport assay, using polarized LLC-MDR1 epithelial cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID529869 | Antimicrobial activity against Escherichia coli AG100A harboring pAT392 containing mph(B) gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID1221960 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1221956 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1888847 | Antibacterial activity against Staphylococcus aureus 1199 measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID520608 | Antimicrobial activity against erythromycin-resistant Group D Streptococcus sp. clinical isolates expressing erm(T) gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Prevalence of the erm(T) gene in clinical isolates of erythromycin-resistant group D Streptococcus and Enterococcus. |
| AID534320 | Antimicrobial activity against mega::aad9-positive Streptococcus pneumoniae XZ8006 expressing PmefE-lacZ gene induced by pretreatment with 50 ug/ml of LL-37 peptide for 1 hr by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID187377 | Plasma concentration in rats was determined by oral administration, 20 mg/kg at 40 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1055326 | Antibacterial activity against extended spectrum beta-lactamase producing Klebsiella pneumoniae ATCC 700603 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID531564 | Antibacterial activity against methicillin-susceptible, coagulase-negative Staphylococcus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID261784 | Antibacterial activity against macrolide resistant Streptococcus pneumoniae ATCC 700677 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID202099 | In Vitro antibacterial activity against Streptococcus pneumoniae 5649 (mefE strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID699539 | Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10 | Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. |
| AID1594145 | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID548253 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID261791 | Antibacterial activity against macrolide resistant Staphylococcus aureus ATCC BAA-39 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID323004 | Antibacterial activity against drug-resistant Propionibacterium acnes P429:1 (SC) after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID1221970 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID560507 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b2k3421 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID210384 | In vitro antibacterial activity against Streptococcus pneumoniae 5649 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID528706 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID113499 | ED50 value was measured by po administration against streptococcus pyogenes infection in mice (in vivo, in experiment 3) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID206099 | In vitro antimicrobial activity against aerobic bacteria Streptococcus B 14 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID209606 | In vitro antibacterial activity against Streptococcus pyogenes PIU 2548 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID278432 | Antibacterial activity against Streptococcus pyogenes M12 by time-kill curve assay | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments. |
| AID571442 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID348716 | Antibacterial activity against efflux-resistant Streptococcus pyogenes 1323 expressing mefA by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID569034 | Antimicrobial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. |
| AID560523 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gs07022 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID508377 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID540220 | Clearance in human after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID562608 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID575160 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose upto 2 mM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID206103 | In vitro antimicrobial activity against aerobic bacteria Streptococcus D 2041 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID278860 | Antiproliferative effect against HeLa cells after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID584343 | Antibacterial activity against kanamycin-resistant acrAB, acrEF deficient Escherichia coli W4680AE presence of 10 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID113988 | Effective dose against mice infected with Staphylococcus aureus after peroral administration (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID309827 | Antimicrobial activity against Staphylococcus aureus ISP447 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID279910 | Attenuation of Burkholderia pseudomallei KHW cytotoxicity in A549 cells at 8 ug/ml in presence of 500 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID603956 | In-vivo serum to lung partition coefficients of the compound, logP(lung) in rat | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. |
| AID1447480 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 101885 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID508370 | Antibacterial activity against Streptococcus pneumoniae harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID586046 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type 2 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID348709 | Antibacterial activity against MLSB-resistant Staphylococcus aureus 27660 expressing ermA by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID520735 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring erm(B) and cfr gene by disk diffusion assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID326010 | Antimicrobial activity against Campylobacter coli MR32D with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID411674 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 2912 expressing erm gene by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID648732 | Antibacterial activity against vancomycin-resistant Enterococcus after 24 hrs by micro dilution method | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds. |
| AID571452 | Ratio of the MIC for Enterobacter cloacae ATCC 23355 in the absence of NAB7061 to MIC for Enterobacter cloacae ATCC 23355 ATCC 13883 in the presence of 4 ug/ml of NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID548534 | Antimicrobial activity against viridans group Streptococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID83801 | MIC value was measured against haemophilus influenzae CL | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID528730 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID562397 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID424771 | Antifungal activity against Candida albicans MY1055 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID498362 | Antimicrobial activity against rifampin resistant Klebsiella pneumoniae 52deltaacrR containing isogenic acrR knockout assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. |
| AID717685 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 09N120 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID562612 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID571268 | Antimicrobial activity against Campylobacter jejuni DC27 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID1137040 | Displacement of [14C]erythromycin from Escherichia coli ribosomes after 30 mins by scintillation spectrometer analysis | 1977 | Journal of medicinal chemistry, May, Volume: 20, Issue:5 | Structure-activity relationships among the O-acyl derivatives of leucomycin. Correlation of minimal inhibitory concentrations with binding to Escherichia coli ribosomes. |
| AID299386 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae OC9132 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID127951 | Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 0.5 hr; No detectable concentration of antibiotic | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID206102 | In vitro antimicrobial activity against aerobic bacteria Streptococcus C 24 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID574715 | Upregulation of fruA gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID168672 | Fluid concentration in kidney tissue was determined in rats at 4 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID508372 | Antibacterial activity against Streptococcus pneumoniae harboring erm(B) and mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID560506 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b3k2345 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID422944 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae harboring A2064G transition in domain V of 23S rRNA isolated from pediatric patients with community-acquired pneumonia after 10 to 14 days by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. |
| AID369438 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID534084 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID535644 | Antimicrobial activity against Group B streptococcus serotype Ib N2 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID326062 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 12 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID718273 | Antimicrobial activity against Bacillus subtilis ATCC 6633 | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID564830 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus sciuri assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1525335 | Antibacterial activity against Staphylococcus aureus BAA-977 expressing iermA by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID528733 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus hominis subsp. novobiosepticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID544525 | Antimicrobial activity against Borrelia garinii isolate PSth after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID458151 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 after 20 hrs by plate dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID561724 | Antibacterial activity against Enterococcus faecium assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID534111 | Antibacterial activity against Pasteurella multocida pm1980 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID209884 | Cell free inhibiting activity against erythromycin-susceptible strain Streptococcus pneumoniae 5635 (Wild type ribosomes for transcription/translation assay) | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID508368 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID565742 | Antimicrobial activity against Streptococcus agalactiae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1562254 | Antimycobacterial activity against Mycobacterium smegmatis atR2 assessed as decrease in drug resistance development at 15 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID278527 | Antimicrobial activity against Bifidobacterium longum ATCC 15707 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID112493 | In Vivo evaluation for its effective dose against Streptococcus pneumoniae (030SJ6 EryRc) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID278500 | Antibacterial activity against Pneumococcus DAW75 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID326055 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 9 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID547191 | Antibacterial activity against Campylobacter jejuni by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea. |
| AID379525 | Antibacterial activity against Escherichia coli ATCC 25922 | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11 | Acetylated flavanone glycosides from the rhizomes of Cyclosorus acuminatus. |
| AID619451 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae B1 expressing erm gene by the broth microdilution method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Novel C-4'' modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation. |
| AID1870151 | Antibacterial activity against wild type Staphylococcus aureus 4717/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID518970 | Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZdelta2-4 mutant leader peptide cistrons reporter plasmid at 25 mg/ml after 36 hrs at 37 degC by disc-based beta-galactosidase reporter gene ass | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID562376 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID573150 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID562404 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID283561 | Effect on modulation in uptake of [3H]progesterone in Escherichia coli AG102 with marR1 mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID516798 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae ATCC 6301 | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19 | 9-Dihydroerythromycins as non-antibiotic motilin receptor agonists. |
| AID512008 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: a novel class of acylides. |
| AID544522 | Antimicrobial activity against Borrelia afzelii isolate FEM1 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID572061 | Ratio of MIC for Acinetobacter baumannii AC0037 to MIC for abeS-deficient Acinetobacter baumannii AC0037 | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID85973 | In vitro antibacterial activity against DILL strain of Haemophilus influenzae. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID424844 | Inhibition of ribosomal activity in erythromycin-resistant Propionibacterium acnes SW54EA with A2058G mutation in domain V of 23S rRNA assessed as luciferase production by transcriptional and translational assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID348719 | Antibacterial activity against Moraxella catarrhalis by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID520737 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring erm(B) promoter-deficient plasmid MS2 by disk diffusion assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID1870156 | Antibacterial activity against wild type Staphylococcus aureus 4515/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID440233 | Agonist activity at motilin receptor in rabbit smooth muscle assessed as tachyphylaxis at EC90 concentration after 4th dose | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety. |
| AID678712 | Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID1326850 | Antibacterial activity against Staphylococcus aureus MB2865 by broth microdilution technique | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | A Gestalt approach to Gram-negative entry. |
| AID278870 | Increase in lactate production in primary human osteoblasts by ELISA relative to control | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID283570 | Effect on modulation in uptake of [3H]progesterone in Escherichia coli HNCE4 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID598801 | Antimicrobial activity against erythromycin-sensitive Streptococcus pneumoniae ATCC 6301 | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series. |
| AID1562252 | Antimycobacterial activity against Mycobacterium smegmatis atR14 assessed as decrease in drug resistance development at 15 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID531561 | Antibacterial activity against coagulase-negative Staphylococcus sciuri obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID588216 | FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID717683 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 09G291 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID557208 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID368423 | Antimicrobial activity against Escherichia coli KAM32 pSTVdeltaqepA containing disrupted qepA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID1685734 | Growth inhibition of Escherichia coli DH5alpha at 25 uM measured every 15 mins for 12 hrs | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12 | Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. |
| AID724505 | Antibacterial activity against penicillin-resistant Staphylococcus aureus clinical isolate by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID543824 | Antimicrobial activity against Borrelia spielmanii isolate PJes after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID586073 | Antibacterial activity against quinupristin-dalfopristin resistant Enterococcus faecium isolate ES022 containing streptogramin A resistance genes vatG and vgaD isolated from swine stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID625276 | FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of most concern for DILI | 2011 | Drug discovery today, Aug, Volume: 16, Issue:15-16 | FDA-approved drug labeling for the study of drug-induced liver injury. |
| AID1221968 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1061907 | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in human Caco2 cells at 10 uM after 90 mins by LC-MS/MS analysis | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1 | The synthesis of novel taxoids for oral administration. |
| AID473938 | Antibacterial activity against penicillin intermediate-resistant Streptococcus pneumoniae isolate I3 by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8 | Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides. |
| AID547657 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 673 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID86123 | In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae 465 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID509631 | Antimicrobial activity against Staphylococcus aureus RN4220 transformant carrying plasmid pKKS25 and expressing erm(T), dfrK and tet(L) genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID547536 | Antimicrobial activity against invasive Streptococcus anginosus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID428243 | Increase in lag phase of growth for Streptococcus pneumoniae PC13 transformant harboring 136-bp deletion in erm(B) gene assessed as doubling time at 1 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID562391 | Antimicrobial activity against oxacillin-susceptible Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID543822 | Antimicrobial activity against Borrelia spielmanii isolate PC-Eq17 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1870157 | Antibacterial activity against wild type Staphylococcus aureus 5079/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID69621 | Antibacterial activity against Escherichia coli NIHJ | 1987 | Journal of medicinal chemistry, Nov, Volume: 30, Issue:11 | Macrolides with gastrointestinal motor stimulating activity. |
| AID530428 | Antimicrobial activity against Mycobacterium smegmatis overexpressing rv0194 gene by microplate Alamar blue assay | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis. |
| AID245097 | Minimum inhibitory concentration against Staphylococcus aureus 6538P (erythromycin-susceptible strain) | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10 | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. |
| AID574911 | Enhancement of biofilm formation Staphylococcus epidermidis SW032 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID1355944 | Antimicrobial activity against Kocuria rhizophila KB212 ATCC 9341 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID532987 | Antibacterial activity against Pseudomonas aeruginosa NCIM 5029 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID571436 | Antibacterial activity against Escherichia coli IH3080 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID366427 | Antibacterial activity against Staphylococcus aureus ATCC 6538P assessed as inhibition zone diameter at 15 ug/disk after 24 hrs by agar diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive brominated metabolites from the red sea sponge Suberea mollis. |
| AID525144 | Antimicrobial activity against Staphylococcus epidermidis isolate 426-3147L expressing cfr gene by broth microdilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. |
| AID571485 | Antimicrobial activity against Campylobacter jejuni JL299 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID670956 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 at 15 ug/disc after 24 hrs by disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID1474193 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 18 to 22 hrs in absence of colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID404948 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus isolate assessed as susceptible resistant isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID520003 | Antimicrobial activity against Legionella pneumophila isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID209472 | In vitro antibacterial activity of PIU2584 strain of Gram positive bacteria Streptococcus pyogenes | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID571885 | Antibacterial activity against Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene by CLSI broth microdilution method in presence of 25 ug/ml efflux pump inhibitor CCCP | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID577691 | Antimicrobial activity against Neisseria gonorrhoeae isolate 254921 NG-MAST sequence type 649 selected after 2 to 8 mg/L of compound by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | High-level azithromycin resistance occurs in Neisseria gonorrhoeae as a result of a single point mutation in the 23S rRNA genes. |
| AID245559 | Minimum inhibitory concentration of the compound againstEnterococcus faecalis ATCC 51299 with an erm(B)-encoded ribosomal methylase was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID565756 | Antimicrobial activity against oxacillin-resistant Staphylococcus epidermidis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID521803 | Antimicrobial activity against Francisella tularensis subsp. holarctica after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | In vitro susceptibility of isolates of Francisella tularensis types A and B from North America. |
| AID326047 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 5 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID565014 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID576138 | Antibacterial activity against 10'4 to 10'5 CFU methicillin-resistant coagulase-negative Staphylococcus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID278861 | Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID516797 | Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19 | 9-Dihydroerythromycins as non-antibiotic motilin receptor agonists. |
| AID573113 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID278522 | Antimicrobial activity against Bifidobacterium bifidum R0071 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID369229 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent resistant isolates by CLSI breakpoint method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID571245 | Antimicrobial activity against Campylobacter jejuni DC4 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID521966 | Antibacterial activity against Campylobacter jejuni assessed as resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID554981 | Antimicrobial activity against Staphylococcus aureus UCN17 with A2058G mutation in rrl allele | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID530529 | Induction of Ppbp2::lacZ gene expression in Staphylococcus aureus SH1000 at 2.5 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials. |
| AID326064 | Effect on Campylobacter jejuni 700819 mutant colonization at 8 ug/ml | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID528722 | Antibacterial activity against Streptococcus viridans clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID531554 | Antibacterial activity against coagulase-negative Staphylococcus epidermidis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID508379 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring erm(B) and mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1355951 | Antimicrobial activity against Acholeplasma laidlawii KB174 PG8 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID1778128 | Antimicrobial activity against Escherichia coli assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID544532 | Antimicrobial activity against Borrelia clinical isolate after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID571487 | Antimicrobial activity against Campylobacter jejuni JL301 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID573116 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID205876 | In vitro inhibitory activity against Staphylococcus epidermidis (EryRi 012GO11i) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID1562255 | Antimycobacterial activity against Mycobacterium smegmatis atR11 assessed as decrease in drug resistance development at 15 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID571260 | Antimicrobial activity against Campylobacter jejuni DC19 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID278503 | Antibacterial activity against Pneumococcus CDC013 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID534323 | Antimicrobial activity against mefE-mel::aph3-positive Streptococcus pneumoniae XZ8009 expressing PmefE-lacZ gene induced by pretreatment with 50 ug/ml of LL-37 peptide for 1 hr by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID174480 | Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 2 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID424616 | Antibacterial activity against Enterococcus avium AIS2007004 isolated from patients rectum by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID1055331 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID208013 | In vitro antibacterial activity against EES61 strain of Streptococcus pyogenes | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID203442 | In vitro inhibitory activity against Staphylococci EryRi (65) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID532026 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 harboring pTY60H assessed as 4-fold increase in reserpine-mediated inhibition of bacterial growth after 14 days | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID571440 | Ratio of the MIC for Escherichia coli IH3080 in the absence of NAB7061 to MIC for Escherichia coli IH3080 in the presence of 4 ug/ml of NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID571252 | Antimicrobial activity against Campylobacter jejuni DC11 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID654380 | Antimicrobial activity against Micrococcus luteus at 10 ug after 24 hrs by paper disk method | 2012 | Journal of natural products, Feb-24, Volume: 75, Issue:2 | JBIR-78 and JBIR-95: phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56. |
| AID562584 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus agalactiae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID576350 | Antimicrobial activity against Chlamydia trachomatis Ic Cal-8 serovar D infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID528732 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus saprophyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID168676 | Fluid concentration in liver tissue was determined in rats at 1 h | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID565740 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus agalactiae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID71030 | In vitro antimicrobial activity against anaerobic bacteria eubacterium aerofaciens 1235 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID565031 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID571258 | Antimicrobial activity against Campylobacter jejuni DC17 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID520086 | Antimicrobial activity against acrAB-deficient Escherichia coli TG1 harboring AcrAB efflux pump by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID717674 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 09Q149 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID565758 | Antimicrobial activity against Staphylococcus epidermidis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID326054 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 8 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID565733 | Antimicrobial activity against Streptococcus Group G clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID8630 | Minimum inhibitory concentration against Staphylococcus aureus A 5278 MLSB-c | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID422943 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae harboring A2063G transition in domain V of 23S rRNA isolated from pediatric patients with community-acquired pneumonia after 10 to 14 days by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. |
| AID528714 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus capitis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID543828 | Antimicrobial activity against Borrelia spielmanii isolate TIsar2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1424068 | Antibiotic activity against methicillin-resistant Staphylococcus aureus isolate CAIRD148 by broth microdilution assay or Alamar blue dye based colorimetric assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. |
| AID533857 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium mageritense after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID678714 | Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID533880 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID531552 | Antibacterial activity against methicillin resistant Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1241210 | Binding affinity to 5'-FAM-pre-miR-17 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID564833 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID326032 | Antimicrobial activity against Campylobacter coli RN14BE8-2 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID565741 | Antimicrobial activity against erythromycin-susceptible Streptococcus agalactiae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID508375 | Antibacterial activity against quinolone-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID547543 | Antimicrobial activity against invasive Streptococcus constellatus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID643383 | Induction of phospholipidosis in bovine corneal fibroblasts assessed as lamellar inclusion bodies after 72 hrs by light microscopy | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. |
| AID278994 | Antibacterial activity against Escherichia coli DH5alpha containing macrolide-resistant pUC18-mph(E)-mrx(E) region | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. |
| AID531572 | Antibacterial activity against Streptococcus mitis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID279913 | Attenuation of Burkholderia pseudomallei KHW cytotoxicity in THP1 cells at 128 ug/ml | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID1240317 | Antibacterial activity against tolC-deficient Escherichia coli NB27005-CDY0039 expressing gyrA S83L D83G, parC S80I mutant by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID565032 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID207219 | In vitro minimum inhibitory concentration against Staphylococcus aureus 6538P using standard agar dilution method | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID167709 | The compound was tested in vitro for prokinetic activity as smooth muscle contractility in isolated rabbit duodenum | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10 | Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate. |
| AID561515 | Antibacterial activity against Enterococcus faecium by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID348708 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus 29213 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID422942 | Antimicrobial activity against macrolide-susceptible Mycoplasma pneumoniae isolated from pediatric patients with community-acquired pneumonia after 10 to 14 days by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. |
| AID279879 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 15.6 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID533853 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium chelonae after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID323006 | Antibacterial activity against drug-resistant Propionibacterium acnes SW54EA after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID326039 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 1 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID531577 | Antibacterial activity against Gemella spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID261799 | Antibacterial activity against Haemophilus influenzae EH002 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID326049 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 6 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1502712 | Antimycobacterial activity against Mycobacterium avium isolate MAV3 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID554659 | Antimicrobial activity against Ureaplasma parvum SV1 isolate UHWQ3 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID360381 | Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake | 2007 | The Journal of biological chemistry, Jan-26, Volume: 282, Issue:4 | In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. |
| AID576134 | Antibacterial activity against 10'4 to 10'5 CFU vancomycin-resistant Enterococcus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID161930 | In vitro inhibitory activity against Pneumococci EryRc (34) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID554873 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 13 harboring ERY-resistant mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID326048 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 5/A2074G and cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID404895 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB10 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID545057 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate SZ009 from patient pus by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID619454 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 by the broth microdilution method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Novel C-4'' modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation. |
| AID564809 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1687315 | Synergistic antibacterial activity against Acinetobacter baumannii ATCC 19606 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID279869 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 31.3 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID1327931 | Antibacterial activity against Bacillus pumilus at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID1355955 | Antimicrobial activity against Saccharomyces cerevisiae BY25929 harboring yrr2/yrs1/pdr1/pdr3 deletion mutant assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID508383 | Antibacterial activity against Streptococcus pyogenes harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID168684 | Fluid concentration in lung tissue was determined in rats at 1 h | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID278859 | Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID208288 | Minimum inhibitory concentration against Streptococcus pneumoniae 5649 efflux | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID323011 | Antibacterial activity against drug-resistant Propionibacterium acnes SP64E after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID554952 | Antimicrobial activity against Escherichia coli at 100 ug/ml after 8 hrs | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID574711 | Antimicrobial activity against Staphylococcus epidermidis SW029 expressing icaA gene assessed as enhancement of biofilm formation after 18 hrs by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID19425 | HPLC capacity factor (k) | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID544276 | Antimicrobial activity against Enterococcus faecalis NKH6 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID571503 | Antimicrobial activity against Campylobacter jejuni DC6 infected in 3 days old chicken by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID187374 | Plasma concentration in rats was determined by oral administration, 20 mg/kg at 20 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID508365 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1159108 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as zone of inhibition at 15 mg for 24 hrs at 37 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID498360 | Antimicrobial activity against rifampin resistant Klebsiella pneumoniae 52145R assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. |
| AID112489 | In Vivo evaluation for its effective dose against Streptococcus pneumoniae (030Cr29 EryRc) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID573136 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID556350 | Antimicrobial activity against Mycoplasma pneumoniae clinical isolate harboring point mutations in 23S rRNA at positions 2063 and 2064 isolated from human respiratory tract by microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China. |
| AID520870 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU47 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID565736 | Antimicrobial activity against Streptococcus Group C clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID384921 | Antibacterial activity against Bacillus subtilis PCI219 assessed as inhibition zone diameter at 10 mg/kg after 24 hrs by paper disk diffusion assay | 2008 | Journal of natural products, Apr, Volume: 71, Issue:4 | Chemical constituents and diversity of Ligularia lankongensis in Yunnan Province of China. |
| AID423272 | Antibacterial activity against 0.01 MOI wild type Chlamydia trachomatis L2/LGV/434/Bu infected in mouse L2 cells treated 2 hrs after infection measured on day 7 by plaque assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. |
| AID1261124 | Antibacterial activity against clinically isolated erythromycin-resistant Streptococcus pyogenes R2 by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID1687316 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID571203 | Antibacterial activity against Escherichia coli ATCC 25992 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID519332 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT09 carrying rplD and rplV mutant genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID530584 | Antimicrobial activity against Mycoplasma pneumoniae isolate 18 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID278559 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID557792 | Antimicrobial activity against Streptococcus pyogenes clinical isolate expressing mosaic variant of mef gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Characterization of macrolide efflux pump mef subclasses detected in clinical isolates of Streptococcus pyogenes isolated between 1999 and 2005. |
| AID79583 | In Vitro antibacterial activity against H. flu DILL (Amp-R strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID113635 | ED50 value was measured by sc administration against streptococcus pyogenes infection in mice (in vivo, in experiment 1) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1261116 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID619452 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae A22072 expressing mef gene by the broth microdilution method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Novel C-4'' modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation. |
| AID278676 | Antibacterial activity against Enterococcus faecalis isolate 5742 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID1261119 | Antibacterial activity against clinically isolated penicillin-resistant Staphylococcus aureus by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID520393 | Antibacterial activity against mef-positive Streptococcus pneumoniae isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID574953 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID379742 | Antibacterial activity against Staphylococcus aureus RN4220 expressing MsrA efflux transporter after 18 hrs by microtiter plate method | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis). |
| AID206743 | In vitro antibacterial activity against Staphylococcus aureus NCTC 10649M strain | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID561755 | Antibacterial activity against Methicillin-sensitive Staphylococcus aureus assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID521825 | Antimicrobial activity against beta-lactam resistant Streptococcus pneumoniae clinical isolate by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID739304 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 assessed as growth inhibition by CLSI broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. |
| AID240820 | Inhibitory concentration against IKr potassium channel | 2004 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18 | The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. |
| AID554860 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 143 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID369445 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1194853 | Antimicrobial activity against Staphylococcus aureus MLS-16 MTCC 2940 assessed as inhibition of biofilm formation after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, May-01, Volume: 25, Issue:9 | One-pot catalyst free synthesis of novel kojic acid tagged 2-aryl/alkyl substituted-4H-chromenes and evaluation of their antimicrobial and anti-biofilm activities. |
| AID571502 | Antimicrobial activity against Campylobacter jejuni DC2 infected in 3 days old chicken by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID278555 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID19468 | Partition coefficient (logP) | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID424835 | Antibacterial activity against erythromycin-resistant Propionibacterium acnes with A2058G mutation in domain V of 23S rRNA | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID571926 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-N623S-Q624S mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID586039 | Antimicrobial activity against Staphylococcus aureus clone 1-1 harboring staphylococcal cassette chromosome mec element type 4 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID1221961 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID767508 | Antibacterial activity against Streptococcus pyogenes 447 by standard dilution assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18 | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. |
| AID564813 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID278672 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5733 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID530538 | Induction of PvraSr::lacZ gene expression in Staphylococcus aureus SH1000 at 2.5 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials. |
| AID571255 | Antimicrobial activity against Campylobacter jejuni DC14 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID209605 | In vitro antibacterial activity against Streptococcus pyogenes EES61 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID565757 | Antimicrobial activity against oxacillin-susceptible Staphylococcus epidermidis clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID533874 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID565737 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus pyogenes clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID209609 | In vitro antibacterial activity against Streptococcus pyogenes strain PIU 2548. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID528736 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus auricularis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID581462 | Antimicrobial activity against chromosomal rrn allele deficient-Escherichia coli TA531 after 15 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID573117 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID554973 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as retardation of 16S rRNA processing at 100 ug/ml after 2 hrs by primer extension analysis at 25 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID279901 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 62.5 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID531629 | Antimicrobial activity against Ureaplasma parvum by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. |
| AID540237 | Phospholipidosis-positive literature compound observed in rat | |||
| AID603985 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Synthesis and antibacterial activity of novel 4″-O-benzimidazolyl clarithromycin derivatives. |
| AID318654 | Antibacterial activity against vancomycin-resistant Enterococcus faecium KU1778 clinical isolate by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID396027 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID571929 | Ratio of MIC for Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-M626I mutant gene to MIC for Escherichia coli K-12 3-AG300 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID508387 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID244905 | Minimum inhibitory concentration against Staphylococcus aureus OC4172 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID584994 | Antibacterial activity against Staphylococcus aureus XU21-T1 harboring cfr-encoding conjugative pSCFS7 and fexA by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. |
| AID1591544 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID542605 | Antimicrobial activity against Pseudomonas aeruginosa H187 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID545047 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ088 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID498880 | Antimicrobial activity against Escherichia cloi RAM1129 transfected with pNK1 containg Neisseria meningitidis tolC gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID565080 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 56 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID411666 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus 29213 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID1596579 | BActericidal activity against Escherichia coli BW25113 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID208925 | MIC value measured against streptococcus pneumoniae Park1 | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID717274 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by CLSI protocol based broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives. |
| AID309824 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 IR94-HR-1 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID325027 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 837 isolate with mutation in erm(B), mef(E), L4 Ser20Asn mutant gene from patient sputum by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID571883 | Antibacterial activity against Escherichia coli KAM32 harboring plasmid pUC18 by CLSI broth microdilution method in presence of 25 ug/ml efflux pump inhibitor CCCP | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID554956 | Inhibition of small ribosomal subunit assembly in Escherichia coli assessed as accumulation of 16S rRNA at 100 ug/ml after 2 hrs by sucrose gradient fractionation at 25 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID575076 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID678722 | Covalent binding affinity to human liver microsomes assessed per mg of protein at 10 uM after 60 mins presence of NADPH | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID203425 | In vitro inhibitory activity against Staphylococci EryRi (65) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID261789 | Antibacterial activity against macrolide resistant Staphylococcus aureus ATCC 33591 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID598141 | Antimicrobial activity against Staphylococcus epidermidis IFO12648 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID535643 | Antimicrobial activity against Group B streptococcus serotype III N3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID575081 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID554654 | Antimicrobial activity against Ureaplasma parvum SV6 isolate HPA23 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID66104 | In vitro antibacterial activity against erythromycin-susceptible Enterococcus faecium ATCC 29212 strain | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. |
| AID534324 | Antimicrobial activity against Streptococcus pneumoniae XZ7042 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID187395 | Plasma concentration in rats was determined by subcutaneous administration, 20 mg/kg at 5 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1551811 | Antibacterial activity against methicillin-resistant Staphylococcus aureus incubated for 18 hrs post 30 mins pre-diffusion by disk diffusion method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID547518 | Antimicrobial activity against Streptococcus anginosus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% defrib | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID278683 | Antibacterial activity against Enterococcus faecalis isolate 5745 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID562396 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID565734 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group C clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID571435 | Ratio of the MIC for Escherichia coli ATCC 25992 in the absence of NAB7061 to MIC for Escherichia coli ATCC 25992 in the presence of 4 ug/ml of NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID523014 | Ratio of Kcat to Km for macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay in presence of ATP | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID717681 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 09M124 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID279877 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 62.5 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID278562 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID424847 | Antibacterial activity against erythromycin-sensitive Propionibacterium acnes EG7NS | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID520002 | Antimicrobial activity against Mycoplasma pneumoniae isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1261121 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae B1 expressing ermB gene by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID565728 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group F clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID624629 | Inhibition of Pgp expressed in MDR1-MDCKII cells measured by calcein-AM assay | 2001 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 299, Issue:2 | Rational use of in vitro P-glycoprotein assays in drug discovery. |
| AID516163 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates assessed as resistant isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID767511 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA-1 by standard dilution assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18 | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. |
| AID1240322 | Antibacterial activity against wild type methicillin-susceptible Staphylococcus aureus ATCC 49951 by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID1261122 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae A22072 expressing mefA gene by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID1677809 | Antibacterial activity against Bacillus subtilis ATCC9372 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID323029 | Antibacterial activity against Corynebacterium minutissimum after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID278485 | Antibacterial activity against Pneumococcus DAW19 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID574714 | Upregulation of atlE gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID534329 | Antimicrobial activity against mega::aad9-positive Streptococcus pneumoniae XZ8004 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID362541 | Antibacterial activity against methicillin-resistant Staphylococcus aureus SA1199B after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID1687312 | Synergistic antibacterial activity against wild type Escherichia coli BW25113 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID548528 | Antimicrobial activity against Oxacillin-resistant coagulase-negative Staphylococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1562253 | Antimycobacterial activity against Mycobacterium smegmatis atR1 assessed as decrease in drug resistance development at 15 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID279867 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 125 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID1870149 | Antibacterial activity against wild type Staphylococcus aureus 4504/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID571925 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-G616N mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID508380 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID531570 | Antibacterial activity against Streptococcus sp. 'group G' obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID535774 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 harboring pTY60H containing pCK0601 carrying the luxAB gene under the hsp60 promoter after 14 days determined according to RLU count by real-time luminescence method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID624626 | Ratio of apparent permeability from basolateral to apical side over apical to basolateral side determined in MDR1-MDCKII cells | 2001 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 299, Issue:2 | Rational use of in vitro P-glycoprotein assays in drug discovery. |
| AID373748 | Antimicrobial activity against mupirocin-resistant methicillin-resistant Staphylococcus aureus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. |
| AID543821 | Antimicrobial activity against Borrelia spielmanii isolate PSig2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID571253 | Antimicrobial activity against Campylobacter jejuni DC12 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID706055 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 incubated for 24 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. |
| AID325015 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 811 isolate with erm(B) resistance gene from patient blood by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID543830 | Antimicrobial activity against Borrelia burgdorferi B31 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID598148 | Antimicrobial activity against Acinetobacter calcoaceticus IFO2552 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID1221974 | Fold activity change at MRP2 ATPase (unknown origin) relative to control | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID369230 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent sensitive isolates by CLSI breakpoint method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID543831 | Antimicrobial activity against Borrelia burgdorferi isolate LW2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1159109 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as zone of inhibition at 15 mg for 24 hrs at 37 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID1241212 | Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay in presence of 100-fold excess of Escherichia coli tRNA | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID588214 | FDA HLAED, liver enzyme composite activity | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID574956 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1687309 | Synergistic antibacterial activity against Escherichia coli ATCC 25922 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID326045 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 4 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1677808 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC43300 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID360366 | Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake | 2007 | The Journal of biological chemistry, Jan-26, Volume: 282, Issue:4 | In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. |
| AID113497 | ED50 value was measured by po administration against streptococcus pyogenes infection in mice (in vivo, in experiment 1) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1153414 | Antimicrobial activity against Staphylococcus aureus MTCC 96 assessed as inhibition of biofilm formation after 24 hrs by crystal violet staining-based assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID576326 | Antibacterial activity against 10'4 to 10'5 CFU methicillin-susceptible Staphylococcus aureus after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID648731 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 15187 after 24 hrs by micro dilution method | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds. |
| AID561342 | Antibacterial activity against Beta-hemolytic Streptococcus group A by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID424769 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae CL5771 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID244954 | Minimum inhibitory concentration against Staphylococcus pneumoniae OC4051 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID428564 | Inhibition of CYP3A4 | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. |
| AID1137038 | Antimicrobial activity against Bacillus subtilis ATCC 6633 by agar dilution method | 1977 | Journal of medicinal chemistry, May, Volume: 20, Issue:5 | Structure-activity relationships among the O-acyl derivatives of leucomycin. Correlation of minimal inhibitory concentrations with binding to Escherichia coli ribosomes. |
| AID530051 | Antimicrobial activity against Staphylococcus aureus 286607-R1 harboring wild type gyrB by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID571439 | Antibacterial activity against Escherichia coli IH3080 by Etest method in presence of 4 ug/ml NAB7064 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID1907653 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus ATCC2858 assessed as biofilm eradication at 200 uM incubated for 24 hrs by crystal violet staining based assay | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Novel benzothiazole‒urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA. |
| AID520088 | Antimicrobial activity against Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring plasmid pEX19Gm by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID207075 | In vitro inhibitory activity against Staphylococcus aureus (011UC4) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID206750 | In vitro antibacterial activity against Staphylococcus aureus strain ATCC 6538P. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID531576 | Antibacterial activity against Gemella morbillorum obtained from complicated skin and skin structure infections by RapID ANA system | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID278499 | Antibacterial activity against Pneumococcus DAW70 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID564832 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus sciuri after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID721789 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as growth inhibition after 24 hrs by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes. |
| AID276733 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents. |
| AID210250 | In vitro antibacterial activity against macrolide-lincosamide-streptogramin resistant Streptococcus pyogenes 2912 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. |
| AID564806 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID544280 | Antimicrobial activity against Enterococcus faecalis NKH10 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID706056 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus Mu3 incubated for 24 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. |
| AID560502 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz06051 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID206793 | Minimum inhibitory concentration against Staphylococcus aureus | 2004 | Journal of medicinal chemistry, Mar-11, Volume: 47, Issue:6 | New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine. |
| AID210249 | In vitro antibacterial activity against efflex resistant Streptococcus pyogenes 1323 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. |
| AID411676 | Antibacterial activity against ampicillin-susceptible Haemophilus influenzae by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID1211884 | Total biliary clearance in iv dosed dog | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID326057 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 10 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID531627 | Antimicrobial activity against Mycoplasma hominis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. |
| AID519664 | Inhibition of PAR2-mediated IL1-beta and SLIGKV-NH2-induced interleukin-8 production in normal human epidermal keratinocytes at 10 uM by ELISA | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. |
| AID533659 | Antimicrobial activity against Staphylococcus aureus RN4220 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID26090 | pKa was measured | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | A comparative NMR study between the macrolide antibiotic roxithromycin and erythromycin A with different biological properties. |
| AID1217708 | Time dependent inhibition of CYP2D6 (unknown origin) at 100 uM by LC/MS system | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID278482 | Antibacterial activity against Pneumococcus DAW13 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID245232 | Minimum inhibitory concentration against Streptococcus pneumoniae ATCC 6303 (erythromycin-susceptible strain) | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10 | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. |
| AID528702 | Antibacterial activity against Streptococcus constellatus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID207252 | In vitro antibacterial activity against erythromycin susceptible Staphylococcus aureus 25923 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. |
| AID585877 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 4 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID767507 | Antibacterial activity against Escherichia coli 236 by standard dilution assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18 | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. |
| AID279892 | Attenuation of THP1 cell invasion by Burkholderia pseudomallei KHW at 8 ug/ml in presence of 250 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID564814 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1778127 | Antimicrobial activity against Staphylococcus aureus assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID554862 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 671 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID371536 | Half life in New Zealand White rabbit gastric antrum at 3 uM | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Identification of small molecule agonists of the motilin receptor. |
| AID571882 | Antibacterial activity against Escherichia coli KAM32 harboring plasmid pUC18 by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID127949 | Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 0.25 hr; No detectable concentration of antibiotic | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID406623 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID571466 | Antimicrobial activity against Campylobacter jejuni JL277 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID323016 | Antibacterial activity against drug-resistant Propionibacterium acnes EG7NS after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID562394 | Antimicrobial activity against oxacillin-susceptible Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID565231 | Antimicrobial activity against Mycobacterium chelonae 9917 harboring pZS01 carrying mspA gene by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID1331164 | Antimicrobial activity against Proteus mirabilis ATCC 7002 after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID1852760 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as bacterial growth inhibition by broth microdilution assay | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9 | Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria. |
| AID1327932 | Antibacterial activity against Pseudomonas aeruginosa ATCC 25619 at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID444054 | Oral bioavailability in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID542386 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ST9 expressing cfr, fexA and erm(C) genes | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID285830 | Antibacterial activity against susceptible Campylobacter jejuni isolates by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Comparison of disk diffusion and agar dilution methods for erythromycin and ciprofloxacin susceptibility testing of Campylobacter jejuni subsp. jejuni. |
| AID520004 | Antimicrobial activity against Ureaplasma urealyticum isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID278509 | Antibacterial activity against Pneumococcus CDC068 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID543823 | Antimicrobial activity against Borrelia spielmanii isolate PHap after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID544830 | Antimicrobial activity against Staphylococcus epidermidis Xen 43 biofilm assessed as log10 CFU/cm'2 in bacterial count in presence of 200 microamperes of electric current by bioelectric effect assay | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID299385 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus OC4172 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID518973 | Antimicrobial activity against Escherichia coli ZK796 harboring empty plasmid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID534318 | Antimicrobial activity against mega::aad9-positive Streptococcus pneumoniae XZ8006 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID520005 | Antimicrobial activity against Mycoplasma hominis isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID717679 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 09H065 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID547664 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus 26001 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID532021 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 harboring pTY60H containing pCK0601 carrying the luxAB gene under the hsp60 promoter after 14 days determined according to CFU counts by bioluminescence method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID561513 | Antibacterial activity against Beta-hemolytic Streptococcus group B by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID564816 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID201265 | In Vitro antibacterial activity against Staphylococcus aureus ATCC 6538P (Ery-S resistant strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID276850 | Antibacterial activity against Haemophilus influenzae | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID379526 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11 | Acetylated flavanone glycosides from the rhizomes of Cyclosorus acuminatus. |
| AID564825 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID135351 | Plasma concentration in mice was determined by subcutaneous administration, 20 mg/kg at 5 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID524559 | Antibacterial activity against Streptococcus pyogenes 117-1612A assessed as bactericidal at 8 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID562523 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium C expressing hylEfm gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID574950 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID681137 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID557793 | Antimicrobial activity against Streptococcus pyogenes clinical isolate expressing mef(A) gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Characterization of macrolide efflux pump mef subclasses detected in clinical isolates of Streptococcus pyogenes isolated between 1999 and 2005. |
| AID530583 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae isolate 2p with A2604G mutation by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID554964 | Inhibition of large ribosomal subunit assembly in Escherichia coli assessed as accumulation of 23S rRNA in 40S fraction at 100 ug/ml after 1 hr by sucrose gradient fractionation at 37 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID1361123 | Bacteriostatic activity against Escherichia coli BW25113 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID326011 | Antimicrobial activity against Campylobacter coli AW-II-35 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1542740 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 measured after 18 hrs by resazurin dye based assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID278566 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID573115 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID533878 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID261792 | Antibacterial activity against macrolide resistant Staphylococcus aureus ATCC BAA-44 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID208127 | In vitro inhibitory activity against Streptococcus pneumoniae (EryRi 030SJ5i) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID571246 | Antimicrobial activity against Campylobacter jejuni DC5 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID483704 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae B1 expressing erm gene by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Synthesis and antibacterial activity of novel 4''-O-arylalkylcarbamoyl and 4''-O-((arylalkylamino)-4-oxo-butyl)carbamoyl clarithromycin derivatives. |
| AID309823 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 IR94 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID404950 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. assessed as percent susceptible isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID207723 | MIC value measured against staphylococcus aureus X1 | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID528731 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID531575 | Antibacterial activity against Bacillus spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID575170 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 200 uM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID565012 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID571486 | Antimicrobial activity against Campylobacter jejuni JL300 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID373749 | Antimicrobial activity against mupirocin-susceptible methicillin-resistant Staphylococcus aureus assessed as resistant rate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. |
| AID557093 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID576135 | Antibacterial activity against 10'4 to 10'5 CFU Enterococcus faecium after 18 hrs by CLSI 2-fold agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. |
| AID529159 | Antibacterial activity against Pseudomonas aeruginosa 100609 after 20 hrs by broth microdilution assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID581469 | Binding affinity to Escherichia coli K-12 70S ribosome 23S rRNA assessed as enhancement of DMS-induced modification of 23S rRNA domain II at nucleotides A752 by primer extension analysis | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID572059 | Antibacterial activity against Acinetobacter baumannii AC0037 by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID1211801 | Drug excretion in Wistar rat assessed as compound excreted into bile at 10 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID554546 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC958 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID554861 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 2916 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID543829 | Antimicrobial activity against Borrelia spielmanii isolate TIsar3 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1327930 | Antibacterial activity against Bacillus subtilis NCTC 10400 at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID326009 | Antimicrobial activity against Campylobacter coli MR32D by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1261214 | Bacteriostatic activity against Staphylococcus aureus Mu50 after 24 hrs | 2015 | Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21 | Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus. |
| AID210386 | In vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID322990 | Antibacterial activity against drug-resistant Propionibacterium acnes SW16 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID1240321 | Antibacterial activity against wild type Staphylococcus aureus ATCC 29213 by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID508376 | Antibacterial activity against quinolone-resistant Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID531573 | Antibacterial activity against Staphylococcus intermedius obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID565738 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID206988 | In vivo Minimum inhibitory conc against erythromycin susceptible Staphylococcus aureus strain Smith by mouse protection test | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. |
| AID1594371 | Antibacterial activity against Acinetobacter baumannii BAA1605 after 18 to 24 hrs in presence of colistin by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID53776 | Minimum inhibitory concentration againstH. influenzae DILL Amp-R | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID325020 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 1016 isolate with erm(B) resistance gene from patient blood by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID524824 | Antibacterial activity against erythromycin resistant Campylobacter sp. by agar plate dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID243422 | log (1/Km) value for human liver microsome cytochrome P450 3A4 | 2005 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 15, Issue:18 | Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. |
| AID210373 | In vitro antibacterial activity of 5649 strain of Gram positive bacteria Streptococcus pneumoniae | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID520007 | Antimicrobial activity against Chlamydophila pneumoniae isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID581606 | Binding affinity to Escherichia coli K-12 Pi complex of 70S ribosome Pi complex U2609C mutant assessed as blockade of tylosin-induced inhibition of AcPhe-puromycin synthesis at 10 uM after 2 mins by liquid scintillation counting | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID584331 | Antibacterial activity against tolC, speE deficient Escherichia coli GD106 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID530121 | Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus 152 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID561736 | Antibacterial activity against Beta-hemolytic Streptococcus group B assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID571470 | Antimicrobial activity against Campylobacter jejuni JL284 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID535346 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by PK/PD technique | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1447481 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate P259-96918 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID678762 | TP_TRANSPORTER: increase in plasma concentration in mdr1a(-/-) mouse | 1998 | Archives of biochemistry and biophysics, Feb-15, Volume: 350, Issue:2 | Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. |
| AID411673 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 1323 expressing mef gene by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID424617 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus AIS2006049 isolated from patients arm wound by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID565003 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus hominis after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID571457 | Antimicrobial activity against Campylobacter jejuni DC32 harboring 23S rRNA A2074G mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID721791 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition after 24 hrs by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes. |
| AID565077 | Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus 144 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID571463 | Antimicrobial activity against Campylobacter jejuni DC38 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID325004 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 115 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID135496 | Plasma concentration of compound in mice by oral administration,20mg/kg at 40 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID527724 | Induction of contraction in rabbit smooth muscle | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. |
| AID1596574 | Antibacterial activity against Escherichia coli BW25113 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID210385 | In vitro antibacterial activity against Streptococcus pneumoniae 5979 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID588218 | FDA HLAED, lactate dehydrogenase (LDH) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID279895 | Attenuation of A549 cell invasion by Burkholderia pseudomallei KHW at 128 ug/ml | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID575679 | Antibacterial activity against Listeria monocytogenes isolated from humans with putative chromosomal mutation | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France. |
| AID206282 | In vitro antibacterial activity against Staphylococcus aureus 1775 (methicillin-resistant strain(MRSA)) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID637553 | Antibacterial activity against Streptococcus pneumoniae 994 expressing mef gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID428138 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae isolate P1501016 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID326041 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 2 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1424059 | Induction of ribosome stalling assessed as induction of stalling of ribosome at ermBL ORF at 50 uM by extension inhibition assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. |
| AID278528 | Antimicrobial activity against Bifidobacterium longum ATCC 15708 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID574710 | Antimicrobial activity against Staphylococcus epidermidis SW036 at 1/1024 X MIC | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID1326854 | Antibacterial activity against Klebsiella pneumoniae MB4005 by broth microdilution technique | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | A Gestalt approach to Gram-negative entry. |
| AID278569 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID516169 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates assessed as resistant isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID1594374 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 18 to 24 hrs in presence of colistin by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID559764 | Antimycobacterial activity against PknGMsm-deficient Mycobacterium smegmatis by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID1055943 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 16 hrs | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID571259 | Antimicrobial activity against Campylobacter jejuni DC18 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID531553 | Antibacterial activity against methicillin susceptible Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID283552 | Antimicrobial activity against Streptococcus pneumoniae PC13 isolate with erm(B) mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1210301 | Apparent intrinsic clearance in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by media-loss method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Aug, Volume: 40, Issue:8 | Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: identifying rate-limiting steps and role of passive processes. |
| AID548745 | Antimicrobial activity against Beta-hemolytic Streptococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID573120 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID369232 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Streptococcus pneumoniae isolates by double-disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID564805 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID125430 | In vitro binding affinity towards human motilin receptor | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7 | Discovery of a potent and novel motilin agonist. |
| AID565011 | Bactericidal activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID206987 | In vivo effective dose against erythromycin susceptible Staphylococcus aureus Smith strain by mouse protection test(95% confidence limits) | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. |
| AID546209 | Antimicrobial activity against Staphylococcus aureus 2171 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain. |
| AID534331 | Antimicrobial activity against mega::aad9-positive Streptococcus pneumoniae XZ8004 expressing PmefE-lacZ gene induced by pretreatment with 100 ug/ml of LL-37 peptide for 1 hr by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID424423 | Antibacterial activity against Enterococcus faecalis HIP15179 coisolated with vancomycin-resistant Staphylococcus aureus by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID531551 | Antibacterial activity against Staphylococcus aureus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID510559 | Antibacterial activity against Escherichia coli AG102MB | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID547524 | Antimicrobial activity against Streptococcus constellatus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% def | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID1453029 | Inhibition of CYP1B1 (unknown origin) expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 7-Ethoxyresorufin as substrate up to 6 mins in presence of NADP+ by spectrofluorometric analysis | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Inhibitors of cytochrome P450 (CYP) 1B1. |
| AID571467 | Antimicrobial activity against Campylobacter jejuni JL278 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID637555 | Antibacterial activity against Haemophilus influenzae 38 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID529302 | Antimicrobial activity against Enterococcus faecalis expressing rRNA methylase gene erm(A) obtained from human by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Detection of the erythromycin rRNA methylase gene erm(A) in Enterococcus faecalis. |
| AID473937 | Antibacterial activity against penicillin intermediate-resistant Streptococcus pneumoniae isolate I2 by agar dilution method | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8 | Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides. |
| AID584332 | Antibacterial activity against tolC, gshB deficient Escherichia coli GD107 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID423273 | Antibacterial activity against azithromycin-tolerant 0.01 MOI Chlamydia trachomatis L2AZM#23 harboring mutation in bacterial ribosomal protein L4 infected in mouse L2 cells treated 2 hrs after infection measured on day 7 by plaque assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. |
| AID573122 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID571490 | Antimicrobial activity against Campylobacter jejuni JL304 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID521967 | Antibacterial activity against Campylobacter coli assessed as resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID573146 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID576352 | Antimicrobial activity against Chlamydia trachomatis 580 serovar H infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID674453 | Antibacterial activity against macrolide-resistant Staphylococcus aureus ATCC 33591 constitutively expressing ermA | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and antibacterial activity of desosamine-modified macrolide derivatives. |
| AID670949 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 at 15 ug/ml after 24 hrs by disc diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. |
| AID1153417 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 2453 assessed as inhibition of biofilm formation after 24 hrs by crystal violet staining-based assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID1591538 | Antibacterial activity against Bacillus subtilis ATCC 9372 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID85786 | In vitro inhibitory activity against Haemophilus AmpR (37) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID598800 | Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12 | The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series. |
| AID278665 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5737 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID508388 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID516159 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates by CLSi method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID261785 | Antibacterial activity against macrolide resistant Streptococcus pneumoniae ATCC 700905 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID424319 | Antimicrobial activity against Dialister pneumosintes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID588210 | Human drug-induced liver injury (DILI) modelling dataset from Ekins et al | 2010 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12 | A predictive ligand-based Bayesian model for human drug-induced liver injury. |
| AID718271 | Antimicrobial activity against Aeromonas hydrophila subsp. hydrophila ATCC 7966 | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID554541 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC879 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID562525 | Antimicrobial activity against pbp5 gene-deficient vancomycin-, fusidic acid-, rifampin-resistant Enterococcus faecium D344SRF-C6 expressing hylEfm gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID571477 | Antimicrobial activity against Campylobacter jejuni JL291 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID574948 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID554550 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC879-2 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID1562251 | Antimycobacterial activity against Mycobacterium smegmatis atR9 assessed as decrease in drug resistance development at 15 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID285831 | Antibacterial activity against erythromycin-resistant Campylobacter jejuni isolates by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Comparison of disk diffusion and agar dilution methods for erythromycin and ciprofloxacin susceptibility testing of Campylobacter jejuni subsp. jejuni. |
| AID530769 | Antimicrobial activity against beta-lactamase producing Staphylococcus aureus SH1000 | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials. |
| AID679106 | TP_TRANSPORTER: transepithelial transport in MDR1-expressing MDCK cells | 2004 | Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 32, Issue:11 | Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. |
| AID1055324 | Antibacterial activity against beta-lactamase producing Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID576110 | Antimicrobial activity against mecA-positive Staphylococcus sciuri assessed as resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. |
| AID544527 | Antimicrobial activity against Borrelia garinii isolate G1 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID571267 | Antimicrobial activity against Campylobacter jejuni DC26 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID209469 | In vitro antibacterial activity of 930 strain of Gram positive bacteria Streptococcus pyogenes | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID1326853 | Antibacterial activity against Haemophilus influenzae MB5363 by broth microdilution technique | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | A Gestalt approach to Gram-negative entry. |
| AID1562250 | Antimycobacterial activity against Mycobacterium smegmatis atR8 assessed as decrease in drug resistance development at 15 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID279868 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 62.5 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID554857 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 2918 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID571489 | Antimicrobial activity against Campylobacter jejuni JL303 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1591541 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID562524 | Antimicrobial activity against pbp5 gene-deficient fusidic acid-, rifampin-resistant Enterococcus faecium D344SRF expressing hylEfm gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID209608 | In vitro antibacterial activity against Streptococcus pyogenes strain EES 61. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID278532 | Antimicrobial activity against Bifidobacterium thermophilum ATCC 25866 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID706054 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 incubated for 24 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. |
| AID540221 | Volume of distribution at steady state in human after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID276736 | Antibacterial activity against Staphylococcus aureus ATCC 6538 | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents. |
| AID114194 | Effective dose in vivo, in mouse inoculated intraperitoneally with 5.09*10e7 CFU of erythromycin susceptible strain Staphylococcus aureus Smith | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13 | Synthesis and antibacterial activity of a novel series of acylides: 3-O-(3-pyridyl)acetylerythromycin A derivatives. |
| AID556348 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae clinical isolates obtained from bronchial aspirations expressing 23S rRNA A2063G mutant gene and P1 RFLP type I gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China. |
| AID571446 | Ratio of the MIC for Klebsiella pneumoniae ATCC 13883 in the absence of NAB7061 to MIC for Klebsiella pneumoniae ATCC 13883 in the presence of 4 ug/ml of NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID278923 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID574903 | Upregulation of atlE gene expression in Staphylococcus epidermidis SW036 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID207220 | In vitro minimum inhibitory concentration against Staphylococcus aureus A5177. | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID598145 | Antimicrobial activity against Klebsiella pneumoniae NCTN9632 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID545043 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ068 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID573147 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID318669 | Antibacterial activity against methicillin-resistant Staphylococcus aureus KT0116 in mouse dosed iv 1 hr after infection | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID285850 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes D-112 transconjugated with erm(B) and tet(M) genes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene. |
| AID348718 | Antibacterial activity against ampicillin-susceptible Haemophilus influenzae by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID574955 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID529885 | Antibacterial activity against Staphylococcus aureus RN4220 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID1594135 | Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID574928 | Enhancement of biofilm formation Staphylococcus epidermidis SW115 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID727095 | Antibacterial activity against Salmonella enterica Typhimurium BN10055 after 18 hrs by broth dilution method | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5 | Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant gram-negative bacteria. |
| AID727094 | Antibacterial activity against Salmonella enterica Typhimurium BN10055 harboring deltaacrB after 18 hrs by broth dilution method | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5 | Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant gram-negative bacteria. |
| AID521831 | Antimicrobial activity against Streptococcus pneumoniae isolated from meningitis patient assessed as percent resistant isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID411668 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 33591 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID575948 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID1055338 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 09-9 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID535569 | Antibacterial activity against Salmonella enterica serovar Typhimurium harboring G235A mutation in rlpD gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro activity of azithromycin against nontyphoidal Salmonella enterica. |
| AID213462 | In vitro antimicrobial activity against anaerobic bacteria usobacterium necrophorum 6054A | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID360363 | Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake | 2007 | The Journal of biological chemistry, Jan-26, Volume: 282, Issue:4 | In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. |
| AID577689 | Antimicrobial activity against Neisseria gonorrhoeae isolate 254921 NG-MAST sequence type 649 by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | High-level azithromycin resistance occurs in Neisseria gonorrhoeae as a result of a single point mutation in the 23S rRNA genes. |
| AID208777 | In vitro antibacterial activity against efflex resistant Streptococcus pneumoniae 7701 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. |
| AID113491 | ED50 value was measured by po administration against staphylococcus aureus infection in mice (in vivo, in experiment 1) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID534087 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID584338 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 5 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID525040 | Antimicrobial activity against fluoroquinolone-susceptible Escherichia coli PS5 harboring GyrA S83L mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. |
| AID573121 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1516022 | Antibacterial activity against Escherichia coli UB1005 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1159113 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as zone of inhibition at 15 mg for 24 hrs at 37 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID573123 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID638882 | Antibacterial activity against Streptococcus pneumoniae 6303 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1667635 | Antibacterial activity against Streptococcus pneumoniae ATCC 700904 | 2020 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9 | Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains. |
| AID564818 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1870139 | Antibacterial activity against wild type methicillin resistant Staphylococcus aureus 5017/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID574952 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1870145 | Antibacterial activity against wild type Staphylococcus aureus 4880/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID561340 | Antibacterial activity against Methicillin-sensitive Staphylococcus aureus by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID279192 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolates from skin or soft tissue infection outpatients | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Treatment and outcomes of infections by methicillin-resistant Staphylococcus aureus at an ambulatory clinic. |
| AID527728 | Inhibition of human ERG at 300 uM | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. |
| AID575148 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS2 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID542601 | Antimicrobial activity against Staphylococcus aureus Becker CP8 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID548472 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID424328 | Antimicrobial activity against Dialister invisus by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID206642 | Minimum inhibitory concentration against Staphylococcus aureus | 2004 | Journal of medicinal chemistry, Mar-11, Volume: 47, Issue:6 | New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine. |
| AID326060 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 11 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID575083 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID202266 | In Vitro antibacterial ativity against Streptococcus pyogenes PIU2548 (mefA strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID1502710 | Antimycobacterial activity against Mycobacterium avium isolate MAV1 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID576337 | Antimicrobial activity against Chlamydia trachomatis serovar G infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID206932 | In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V140, | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID544524 | Antimicrobial activity against Borrelia afzelii isolate G1039 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID262717 | Permeability in Caco-2 cell | 2006 | Journal of medicinal chemistry, Apr-06, Volume: 49, Issue:7 | Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. |
| AID326063 | Antimicrobial activity against Campylobacter coli AW-ll-35/AW-ll-37 mutant in chickens assessed as reduction in colonization | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID534344 | Antimicrobial activity against Burkholderia pseudomallei Bp174 harboring mini-Tn7T-bpeR+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1159111 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 35032 assessed as zone of inhibition at 15 mg for 24 hrs at 37 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID1517608 | Antibacterial activity against Klebsiella pneumoniae ATCC 13443 assessed as growth inhibition | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines. |
| AID598147 | Antimicrobial activity against Enterobacter aerogenes NCTC10006 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID573118 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID554545 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC879 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID554977 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as reduction in mature 23S rRNA at 7 ug/ml in presence of E-peptide | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID1221971 | Apparent permeability from apical to basolateral side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1739431 | Permeability across apical to basolateral side in human Caco-2 cells assessed as transepithelial electrical resistance at 10 uM incubated for 2 hrs LC-MS/MS analysis | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. |
| AID508371 | Antibacterial activity against Streptococcus pneumoniae harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID560500 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate sh06024 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID564828 | Bactericidal activity against methicillin-resistant coagulase-negative Staphylococcus simulans after 24 hrs by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID388084 | Antifungal activity at Yarrowia lipolytica | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID678445 | Antibacterial activity against Micrococcus luteus at 12 ug/well after 24 hrs by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction. |
| AID230775 | Range for minimum inhibitory concentration against Staphylococcus aureus; 0.5->16 | 2004 | Journal of medicinal chemistry, Mar-11, Volume: 47, Issue:6 | New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine. |
| AID530582 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae isolate 11 with A2604G mutation by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID309831 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis NCTC-12201 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID542388 | Antimicrobial activity against Staphylococcus aureus RN4220 transformed with Staphylococcus aureus ST398 plasmid pSCFS3 carrying cfr and fexA genes | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID562601 | Antimicrobial activity against oxacillin-susceptible Staphylococcus epidermidis clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1515035 | Induction of translation arrest in tolC-deficient Escherichia coli harboring pRFPCER-TrpL2A assessed as increase in pRFPCER-TrpL2A reporter activity at 10 mg/ml after overnight incubation by dual fluorescent-reporter gene assay | 2019 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2 | Synthesis and evaluation of biological activity for dual-acting antibiotics on the basis of azithromycin and glycopeptides. |
| AID508366 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID278526 | Antimicrobial activity against Bifidobacterium infantis ATCC 15697 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID309822 | Antimicrobial activity against Staphylococcus aureus Smith by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID278681 | Antibacterial activity against Enterococcus faecium isolate 5752 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID326075 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae NMU112 infected CBA/J mouse assessed as median survival time at 20 mg/kg, po relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID325018 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 918 isolate with erm(B) resistance gene from patient eye by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID1525338 | Antibacterial activity against Enterococcus faecalis UNT-047 expressing ermB by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID1217727 | Intrinsic clearance for reactive metabolites formation per mg of protein in human liver microsomes based on [3H]GSH adduct formation rate at 100 uM by [3H]GSH trapping assay | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID1602919 | Apparent permeability from apical to basolateral side in human Caco2 cells at 5 uM after 90 mins | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. |
| AID524826 | Antibacterial activity against erythromycin resistant Campylobacter sp. assessed as resistance breakpoint by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID1602920 | Apparent permeability from basolateral to apical side in human Caco2 cells at 5 uM after 90 mins | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. |
| AID322989 | Antibacterial activity against drug-resistant Propionibacterium acnes SW10 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID544820 | Antimicrobial activity against Staphylococcus epidermidis Xen 43 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID527727 | Inhibition of human ERG at 30 uM | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. |
| AID244955 | Minimum inhibitory concentration against Staphylococcus pneumoniae OC4421 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID276851 | Inhibition of LPS-induced TNFalpha release in human PBMC at 10 uM relative to Dexamethasone | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID584330 | Antibacterial activity against ygiBC, yjfMC, gspS deficient Escherichia coli GD108 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID681121 | TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing MDCKII cells | 2001 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 299, Issue:2 | Rational use of in vitro P-glycoprotein assays in drug discovery. |
| AID560513 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b6k7974 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID571484 | Antimicrobial activity against Campylobacter jejuni JL298 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID560510 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b5k3529 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID562355 | Antimicrobial activity against fusidic acid-, rifampin-resistant Enterococcus faecium TX1330RF by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID209625 | In vitro minimum inhibitory concentration against Streptococcus pyogenes EES61 using standard agar dilution method | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID554866 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 2917 harboring ERY-resistant erm(B) and mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID278853 | Cytotoxicity against primary human osteoblasts at 400 ug/ml assessed as LDH release after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID210375 | In vitro antibacterial activity of 5979 strain of Gram positive bacteria Streptococcus pneumoniae | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID532221 | Antibacterial activity against macrolide-lincosamide-streptogramin B-positive, beta-lactamase-positive, methicillin-resistant Staphylococcus aureus isolate 6 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID424327 | Antimicrobial activity against Dialister propionicifaciens by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID244987 | Minimum inhibitory concentration against Staphylococcus haemolyticus OC4545 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID326017 | Antimicrobial activity against Campylobacter jejuni S3BE4-1 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID554971 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as retardation of 16S rRNA processing at 7 ug/ml after 1 hr by primer extension analysis at 37 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID1870153 | Antibacterial activity against wild type Staphylococcus aureus 4461/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID1331165 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID1176918 | Reduction of extracellular DNA in Pseudomonas aeruginosa biofilm after 48 hrs by UV-spectrophotometry | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Synthesis and anti-biofilm activities of dihydro-pyrrol-2-one derivatives on Pseudomonas aeruginosa. |
| AID562363 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID406621 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID511429 | Antimicrobial activity against Clostridium perfringens LFM1 assessed as susceptibility breakpoint by DIN-standardized microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. |
| AID574910 | Enhancement of biofilm formation Staphylococcus epidermidis SW029 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID767510 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by standard dilution assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18 | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. |
| AID423265 | Antibacterial activity against 0.01 MOI wild type Chlamydia psittaci 6BC BCRB infected in mouse L2 cells treated 2 hrs after infection measured on day 7 by plaque assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. |
| AID404934 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID571272 | Antimicrobial activity against Campylobacter jejuni DC31 harboring 23S rRNA A2074G mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID424332 | Antimicrobial activity against Dialister invisus assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID1355945 | Antimicrobial activity against Mycobacterium smegmatis KB42 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID560501 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz06040 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID584334 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 5 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1870141 | Antibacterial activity against wild type Staphylococcus aureus 4463/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID278675 | Antibacterial activity against Enterococcus faecalis isolate 5743 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID524556 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 assessed as bactericidal at 2 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID299388 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4438 containing mef(A) by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID318648 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID724497 | Antibacterial activity against Salmonella typhimurium TA102 by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID554555 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC1028 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID1594375 | Antibacterial activity against Escherichia coli BW25113 after 18 to 24 hrs in absence of colistin by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID278506 | Antibacterial activity against Pneumococcus CDC023 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID318647 | Antibacterial activity against methicillin-resistant Staphylococcus aureus KMP9 clinical isolate by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID278858 | Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID531563 | Antibacterial activity against methicillin-resistant, oxacillin-susceptible, coagulase-negative, mecA-positive Staphylococcus lugdunensis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID135348 | Plasma concentration in mice was determined by subcutaneous administration, 20 mg/kg at 40 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID561514 | Antibacterial activity against Enterococcus faecalis by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID66558 | In vitro inhibitory activity against enterococci EryRi (19) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID573142 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID452742 | Antibacterial activity against Escherichia coli M15 containing pQE30 expression vector | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1 | Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. |
| AID559766 | Antimycobacterial activity against PknGMsm-deficient Mycobacterium smegmatis harboring PknG Mtb gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID278677 | Antibacterial activity against Enterococcus faecium isolate 2547 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID562371 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group C clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278920 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID549015 | Antimicrobial activity against viridans group Streptococcus assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1217728 | Intrinsic clearance for reactive metabolites formation per mg of protein based on cytochrome P450 (unknown origin) inactivation rate by TDI assay | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID588219 | FDA HLAED, gamma-glutamyl transferase (GGT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID670958 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 24 hrs by microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. |
| AID409940 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2008 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22 | Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs. |
| AID717273 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus 8325-4 by CLSI protocol based broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives. |
| AID1542749 | Potentiation of erythromycin-induced antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as concentration required to restore 2 ug/ml erythromycin activity measured after 18 hrs | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID560223 | Antibacterial activity against Salmonella enterica serovar Typhimurium R200 expressing Outer membrane protein STM3031 by CLSI M7-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID279873 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 1000 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID326091 | Antimicrobial activity against Streptococcus pneumoniae NMU112 infected in po dosed CBA/J mouse assessed as delaying in development of bacteremia relative to roxithromycin | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID520738 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring cfr gene with mutagenized first codon CAG | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID520612 | Antimicrobial activity against Group D Enterococcus faecium clinical isolate expressing erm(B) gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Prevalence of the erm(T) gene in clinical isolates of erythromycin-resistant group D Streptococcus and Enterococcus. |
| AID288350 | Antibacterial activity against Staphylococcus aureus-M after 24 hrs by microdilution method | 2007 | Bioorganic & medicinal chemistry, Jul-01, Volume: 15, Issue:13 | Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides. |
| AID1326851 | Antibacterial activity against Enterococcus faecalis MB5407 by broth microdilution technique | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | A Gestalt approach to Gram-negative entry. |
| AID521804 | Antimicrobial activity against Francisella tularensis subsp. holarctica LVS after 48 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | In vitro susceptibility of isolates of Francisella tularensis types A and B from North America. |
| AID532219 | Antibacterial activity against macrolide-lincosamide-streptogramin B-negative, beta-lactamase-positive, methicillin-susceptible Staphylococcus aureus isolate 4 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID244986 | Minimum inhibitory concentration against Staphylococcus haemolyticus OC3882 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID532019 | Antibacterial activity against macrolide-lincosamide-streptogramin B-positive, beta-lactamase-positive, methicillin-resistant Staphylococcus aureus ATCC 43300 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID717684 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 09A011 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID681122 | TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1221957 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID309826 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 92-1191 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID318645 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID326025 | Antimicrobial activity against Campylobacter coli RN14BE4-2 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID571441 | Antibacterial activity against Escherichia coli IH3080 by Etest method in presence of NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID245669 | Minimum inhibitory concentration of the compound against 3 erythromycin-susceptible Streptococcus pneumoniae OC4421 with an mef(A) efflux-mediated resistance was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID508381 | Antibacterial activity against macrolide-susceptible Streptococcus pyogenes after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID524894 | Antibacterial activity against macrolide resistant and mef(E)-positive Streptococcus pneumoniae by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. |
| AID411934 | Potentiation of electrical field stimulation-induced contraction in New Zealand white rabbit gastric antrum at 1 uM | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. |
| AID135346 | Plasma concentration in mice was determined by subcutaneous administration, 20 mg/kg at 2 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1137039 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 by agar dilution method | 1977 | Journal of medicinal chemistry, May, Volume: 20, Issue:5 | Structure-activity relationships among the O-acyl derivatives of leucomycin. Correlation of minimal inhibitory concentrations with binding to Escherichia coli ribosomes. |
| AID562357 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID540218 | Clearance in monkey after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID565193 | Antimicrobial activity against efflux pump CraA deficient Acinetobacter baumannii JVAB01 receiving pJV103 harboring open reading frame orf3 encoded efflux pump CraA by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. |
| AID521830 | Antimicrobial activity against Streptococcus pneumoniae isolated from meningitis patient assessed as percent susceptible isolates by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan. |
| AID586056 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 6 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID533861 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium septicum after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID411908 | Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. |
| AID561740 | Antibacterial activity against Beta-hemolytic Streptococcus group A assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID562520 | Antimicrobial activity against vancomycin-, gentamicin-resistant Enterococcus faecium B expressing hylEfm gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID174470 | Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 0.25 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID739303 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 assessed as growth inhibition by CLSI broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. |
| AID168666 | Fluid concentration in kidney tissue was determined in rats at 0.5 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID565030 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID717689 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID424762 | Antibacterial activity against ampicillin-sensitive Staphylococcus haemolyticus CL8544 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID573130 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1127991 | Antibacterial activity against fluoroquinolone-resistant Staphylococcus aureus 1199B expressing NorA after 24 hrs by microdilution method | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6 | First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. |
| AID571469 | Antimicrobial activity against Campylobacter jejuni JL283 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID278487 | Antibacterial activity against Pneumococcus DAW24 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID369651 | Antibacterial activity against Campylobacter jejuni UA709 cmeB::kanamycin-resistant mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. |
| AID610793 | Antibacterial activity against Staphylococcus aureus ATCC 6538P at 15 ug/disk after 24 hrs by agar diffusion method | 2011 | Journal of natural products, Jun-24, Volume: 74, Issue:6 | Brominated arginine-derived alkaloids from the red sea sponge Suberea mollis. |
| AID424759 | Antibacterial activity against macrolide-sensitive, Linezolid, methicillin-resistant Staphylococcus aureus CL5814 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID424838 | Displacement of [14C]ERY from erythromycin-sensitive Escherichia coli BL21 ribosome | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID565005 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID554655 | Antimicrobial activity against Ureaplasma parvum SV14 isolate HPA32 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID518975 | Induction of erm(C) expression in Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid assessed as increase in A2058 dimethylation in 23S rRNA at 25% MIC after 4 hrs by primer extension assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID208004 | In vitro antimicrobial activity against aerobic bacteria Streptococcus viridans 9943 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID278925 | Antibacterial activity against Haemophilus influenzae | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID1240319 | Antibacterial activity against Escherichia coli imp-4213 by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID678713 | Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID494440 | Antibacterial activity against Bacillus subtilis ATCC 6633 at 100 ug after 24 hrs by paper disc method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. |
| AID554871 | Antimicrobial activity against Streptococcus pneumoniae serotype 6B ST 90 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID571451 | Antibacterial activity against Enterobacter cloacae ATCC 23355 ATCC 13883 by Etest method in presence of 4 ug/ml NAB7064 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID278525 | Antimicrobial activity against Bifidobacterium breve ATCC 15700 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID278570 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID1594367 | Antibacterial activity against Acinetobacter baumannii BAA1605 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID584339 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 10 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID575078 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID279870 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 15.6 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID561341 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID588220 | Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset | 2008 | Toxicology mechanisms and methods, , Volume: 18, Issue:2-3 | Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. |
| AID325025 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 838 isolate with erm(B) and mef(E) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID523010 | Activity at macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID508689 | Induction of hla virulent gene expression in Staphylococcus aureus PC322 containing hla::lacZ assessed as color chage at 5 ug/ml at 37 degC in presence of chromogenic beta-galactosidase substrate | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Method for screening compounds that influence virulence gene expression in Staphylococcus aureus. |
| AID278479 | Antibacterial activity against Pneumococcus DAW8 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID571494 | Antimicrobial activity against Campylobacter jejuni JL308 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID263390 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4421 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID347504 | Half life in rabbit gastric antrum native tissue at 3 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID560520 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate sh07043 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID571479 | Antimicrobial activity against Campylobacter jejuni JL293 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID168833 | Fluid concentration in urine was determined in rats at 1 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID522946 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID548738 | Antimicrobial activity against Oxacillin-resistant Staphylococcus aureus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID584993 | Antibacterial activity against Staphylococcus aureus XU21 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. |
| AID565034 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus simulans assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID396029 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID576345 | Bactericidal activity against Chlamydia trachomatis serovar G infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID143746 | Inhibition of N-acetylphenylalanine-tRNA peptide bond formation by puromycin reaction at 10E-6 M | 1989 | Journal of medicinal chemistry, Sep, Volume: 32, Issue:9 | Synthesis and biological activity of photoactive derivatives of erythromycin. |
| AID547665 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 6538p by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID318646 | Antibacterial activity against methicillin-resistant Staphylococcus aureus KT0116 clinical isolate by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID574717 | Upregulation of sarA gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID535645 | Antimicrobial activity against Group B Streptococcus serotype Ia N1 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID554954 | Inhibition of large ribosomal subunit assembly in Escherichia coli assessed as accumulation of 23S rRNA in 70S and 50S fractions at 100 ug/ml after 2 hrs by sucrose gradient fractionation at 25 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID125429 | In vitro effective concentration towards human motilin receptor | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7 | Discovery of a potent and novel motilin agonist. |
| AID168835 | Fluid concentration in urine was determined in rats at 4 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID279906 | Attenuation of A549 cell invasion by Burkholderia pseudomallei KHW at 8 ug/ml | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID285848 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes C-105 transconjugated with erm(B) and tet(M) genes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene. |
| AID157260 | In vitro antimicrobial activity against anaerobic bacteria eubacterium peptostreptococcus anaerobius 1428, | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID276853 | Inhibition of PHA-induced IFN-gamma release in human PBMC at 10 uM relative to Dexamethasone | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID323033 | Antibacterial activity against borderline oxacillin-resistant Staphylococcus aureus after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID326018 | Antimicrobial activity against Campylobacter jejuni S3BE4-1 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID573151 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID574719 | Upregulation of icaA gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 24 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID554863 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 236 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID424839 | Displacement of [14C]ERY from erythromycin-sensitive Propionibacterium acnes EG7NS ribosome | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID326031 | Antimicrobial activity against Campylobacter coli RN14BE8-2 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID519066 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 by CLSI microdilution susceptibility testing method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. |
| AID261794 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID548740 | Antimicrobial activity against Oxacillin-resistant coagulase-negative Staphylococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID598139 | Antimicrobial activity against Staphylococcus aureus Smith by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID575145 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS71 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID325021 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 1017 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID520733 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring plasmid MS2 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID283560 | Antibacterial activity against Escherichia coli HNCE4 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID326030 | Antimicrobial activity against Campylobacter coli RN14BE8-1 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID554966 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as accumulation of partially processed 23S rRNA in 30S, 40S and 50S fractions at 100 ug/ml after 1 hr by primer extension analysis at 37 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID565002 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1544292 | Antibacterial activity against multi drug resistant Enterococcus faecium NCTC 7171 incubated for 24 hrs by broth dilution method | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11 | Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens. |
| AID208300 | Minimum inhibitory concentration against Streptococcus pneumoniae ATCC 6303 Ery-S | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID1241207 | Inhibition of pre-miR-373 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID572060 | Antibacterial activity against abeS-deficient Acinetobacter baumannii AC0037 by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID424324 | Antimicrobial activity against Dialister micraerophilus assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID574720 | Upregulation of atlE gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 24 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID278668 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 2530 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID1542741 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 measured after 18 hrs by resazurin dye based assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID388087 | Antibacterial activity at Staphylococcus aureus | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID534343 | Antimicrobial activity against Burkholderia pseudomallei Bp173 harboring mini-Tn7T after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID565739 | Antimicrobial activity against Streptococcus pyogenes clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1217712 | Time dependent inhibition of CYP2C8 (unknown origin) at 100 uM by LC/MS system | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID1355943 | Antimicrobial activity against Bacillus subtilis KB211 ATCC 6633 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID554648 | Antimicrobial activity against Ureaplasma urealyticum isolate HPA3 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID559768 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 100 mg/l after 7 days by microscopy | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID88731 | In vitro antibacterial activity against erythromycin-susceptible Hemophilus influenzae ATCC 43095 strain | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. |
| AID1393955 | Antibacterial activity against linezolid/methicillin resistant Staphylococcus aureus NR 45924 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID348717 | Antibacterial activity against MLSB-resistant Streptococcus pyogenes 2912 expressing ermA by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID535360 | Antimicrobial activity against Haemophilus influenzae clinical isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1237457 | Inhibition of bio-film formation of Escherichia coli MTCC 739 incubated for 24 hrs at 37 degC under static conditions by crystal violet staining method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID530585 | Antimicrobial activity against Mycoplasma pneumoniae isolate 19 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID531628 | Antimicrobial activity against Mycoplasma fermentans by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. |
| AID717677 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 09D016 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID560250 | Antibacterial activity against Staphylococcus aureus RN4220 harboring aadD and tet(L) gene by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID206752 | In vitro antibacterial activity against Staphylococcus aureus strain A 5278. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID554965 | Inhibition of small ribosomal subunit assembly in Escherichia coli assessed as accumulation of 16S rRNA at 100 ug/ml after 1 hr by sucrose gradient fractionation at 37 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID531626 | Antimicrobial activity against Mycoplasma genitalium by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. |
| AID534108 | Antibacterial activity against Pasteurella multocida pm0527 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID516165 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates by CLSi method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID573153 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1542761 | Potentiation of erythromycin-induced antibacterial activity against Acinetobacter baumannii ATCC 19606 assessed as concentration required to restore 2 ug/ml erythromycin activity measured after 18 hrs | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID1221958 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID444051 | Total clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID518968 | Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZalpha reporter plasmid at 4.5 mg/ml after 36 hrs at 37 degC by disc-based beta-galactosidase reporter gene assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID404952 | Antibacterial activity against methicillin-susceptible coagulase-negative Staphylococcus sp. assessed as percent susceptible isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID326046 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 4/A2074G and cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID648730 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by micro dilution method | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds. |
| AID86131 | In vitro minimum inhibitory concentration against Haemophilus influenzae DILL using standard agar dilution method | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID1772152 | Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth by CLSI based microdilution method | 2021 | Journal of natural products, 11-26, Volume: 84, Issue:11 | Antimicrobial and Cytotoxic Angucyclic Quinones from |
| AID565009 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID576351 | Antimicrobial activity against Chlamydia trachomatis Bour serovar E infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID498881 | Antimicrobial activity against Escherichia cloi RAM4100 transfected with pGCC4 containg IPTG-inducible lacZ promoter by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID554674 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 156 harboring ERY-resistant mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID309830 | Antimicrobial activity against Staphylococcus aureus 8325 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID278550 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID562370 | Antimicrobial activity against Streptococcus Group G clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1055345 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis ATCC 12228 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID325016 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 833 isolate with erm(B) resistance gene from patient sinuitis by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID562606 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID521964 | Antimicrobial activity against erythromycin susceptible Campylobacter sp. assessed as clear zone of inhibition by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID1516029 | Antibacterial activity against Staphylococcus aureus 11011 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID202129 | In Vitro antibacterial ativity against Streptococcus pyogenes 930 (ermB strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID564819 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID535356 | Antimicrobial activity against Streptococcus pyogenes clinical isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID576109 | Antimicrobial activity against mecA-deficient Staphylococcus sciuri assessed as resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. |
| AID574930 | Antimicrobial activity against Staphylococcus epidermidis SW029 expressing icaA gene assessed as formation of multilayer biofilms at 48 hrs by SEM | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID150759 | P-gp activity was measured by a direct transport assay, using polarized LLC-mdr1a epithelial cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID508382 | Antibacterial activity against Streptococcus pyogenes harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID565017 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID285156 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID576348 | Bactericidal activity against Chlamydia trachomatis serovar J infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID535358 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as susceptible isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID365669 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 after 24 hrs by twofold serial dilution method | 2008 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16 | Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment. |
| AID424770 | Antibacterial activity against Streptococcus pyogenes CL10440 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID519067 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 assessed as resistant strains by CLSI microdilution susceptibility testing method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. |
| AID560224 | Antibacterial activity against Salmonella enterica serovar Typhimurium R200 expressing stm3031 gene deletion mutant by CLSI M7-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID681166 | TP_TRANSPORTER: Western blot, LS180 cell | 1996 | Molecular pharmacology, Feb, Volume: 49, Issue:2 | Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. |
| AID576349 | Bactericidal activity against Chlamydia trachomatis serovar K infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID520742 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus RN4220 harboring erm(B) and cfr gene assessed as modification of A2058 site in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID404903 | Antibacterial activity against Streptococcus bovis ATCC 33317 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID209470 | In vitro antibacterial activity of EES61 strain of Gram positive bacteria Streptococcus pyogenes | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID535359 | Antimicrobial activity against Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID565228 | Antimicrobial activity against Mycobacterium chelonae ATCC 35752 by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID560249 | Antibacterial activity against Staphylococcus aureus RN4220 harboring tet(L), dfrK gene by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID717682 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 09R476 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID571266 | Antimicrobial activity against Campylobacter jejuni DC25 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID520874 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU90 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID562610 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID565039 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID544526 | Antimicrobial activity against Borrelia garinii isolate M2094 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID529866 | Antimicrobial activity against Streptococcus uberis UCN60 expressing mph(B) and rdmC-like genes by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID544272 | Antimicrobial activity against Enterococcus faecalis NKH2 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1221976 | Transporter substrate index ratio of permeability from basolateral to apical side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID278857 | Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID765062 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 | Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. |
| AID1870136 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 77/CF assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID574923 | Enhancement of biofilm formation Staphylococcus epidermidis SW070 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID565759 | Antimicrobial activity against oxacillin-resistant Staphylococcus aureus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1617372 | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM after 15 to 90 mins by LC-ESI-MS/MS analysis | 2019 | Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22 | Development of Robust 17( |
| AID560503 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 6zjsau7 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID404901 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB41 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID424329 | Antimicrobial activity against Dialister propionicifaciens assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID781326 | pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/047145026X | 2014 | Pharmaceutical research, Apr, Volume: 31, Issue:4 | Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. |
| AID1474190 | Antibacterial activity against Escherichia coli O157:H7 ATCC 35150 after 18 to 22 hrs in absence of colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID562375 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID574708 | Antimicrobial activity against Staphylococcus epidermidis SW029 expressing icaA gene | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID595938 | Antiparasitic activity against Toxoplasma gondii 2F-1 expressing yellow fluorescent protein infected in HFF after 4 days | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Chemistry and biology of macrolide antiparasitic agents. |
| AID571480 | Antimicrobial activity against Campylobacter jejuni JL294 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID565079 | Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus 147 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID576340 | Antimicrobial activity against Chlamydia trachomatis serovar J infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID574721 | Upregulation of fruA gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 24 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID283557 | Antimicrobial activity against Streptococcus pneumoniae R6 with L4 69GTG71 to TPS mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID66414 | In vitro inhibitory activity against enterococci EryRi (19) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID535771 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 harboring pTY60H carrying the luxAB gene under the hsp60 promoter agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID557091 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method in presence of 4% human serum albumin | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID573138 | Antibacterial activity against erythromycin-susceptible Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1240320 | Antibacterial activity against fluoroquinolone-resistant Escherichia coli CH10 harboring gyrA S83L D87N, parC S80I E84G, AcrA+ by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID1055327 | Antibacterial activity against beta-lactamase producing Escherichia coli 09-20 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID326050 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 6/A2074G and cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID373747 | Antimicrobial activity against mupirocin-susceptible methicillin-resistant Staphylococcus aureus by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. |
| AID127934 | Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 0.5 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID557794 | Antimicrobial activity against Streptococcus pyogenes clinical isolate expressing mef(E) gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Characterization of macrolide efflux pump mef subclasses detected in clinical isolates of Streptococcus pyogenes isolated between 1999 and 2005. |
| AID520869 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU33 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID533862 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium wolinskyi after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID564807 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus simulans assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID544271 | Antimicrobial activity against Enterococcus faecalis NKH1 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID424848 | Antibacterial activity against erythromycin-resistant Propionibacterium acnes P95 with 23S rRNA G2057A mutant | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID519334 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT11 carrying rplD and rplV mutant genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID411671 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 700906 expressing erf gene by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID531578 | Antibacterial activity against Lactococcus lactis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID589159 | Mechanism based inhibition of human cytochrome P450 3A4 measured by triazolam 4- hydroxylation using recombinant CYP3A4 | 2005 | Current drug metabolism, Oct, Volume: 6, Issue:5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
| AID524900 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B resistant erm(B) and mef(E)-positive Streptococcus pneumoniae by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. |
| AID562599 | Antimicrobial activity against Staphylococcus haemolyticus clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278564 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15708 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID532983 | Antibacterial activity against Escherichia coli W3110 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID584336 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 15 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID571765 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID318670 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 in mouse dosed iv 1 hr after infection | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID562410 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group G clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID554542 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC958 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID562597 | Antimicrobial activity against oxacillin-resistant Staphylococcus haemolyticus clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID547660 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 1210 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID574924 | Enhancement of biofilm formation Staphylococcus epidermidis SW071 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID544281 | Antimicrobial activity against Enterococcus faecalis NKH11 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID209723 | In vitro antimicrobial activity against aerobic bacteria Streptococcus pneumoniae B1-438 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID278667 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 2513 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID423266 | Antibacterial activity against azithromycin-resistant 0.01 MOI Chlamydia psittaci 6BC BCRBAZ2 harboring A2058C mutation in bacterial 23S rRNA gene infected in mouse L2 cells treated 2 hrs after infection measured on day 7 by plaque assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. |
| AID206931 | In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V135 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID278489 | Antibacterial activity against Pneumococcus DAW27 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID424765 | Antibacterial activity against vancomycin, macrolide-resistant, linezolid-sensitive Enterococcus faecalis CL5246 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID508691 | Induction of hla virulent gene expression in Staphylococcus aureus PC322 containing hla::lacZ assessed as color chage at 5 ug/ml at 37 degC in presence of chromogenic beta-galactosidase substrate and 1 to 50 % glucose solution | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Method for screening compounds that influence virulence gene expression in Staphylococcus aureus. |
| AID584342 | Antibacterial activity against kanamycin-resistant acrAB, acrEF deficient Escherichia coli W4680AE presence of 5 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID528725 | Antibacterial activity against Streptococcus intermedius clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID19403 | Calculated partition coefficient (logD) | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID279866 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 250 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID520875 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolates isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID325028 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 326 isolate with erm(B) resistance gene from patient blood by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID326036 | Antimicrobial activity against Campylobacter coli MR32DE4-1 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID533665 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID326007 | Antimicrobial activity against Campylobacter coli RN14B by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1762629 | Antibacterial activity against Escherichia coli ATCC 25922 by CLSI based microplate assay | |||
| AID564829 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus sciuri after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1594377 | Antibacterial activity against AcrAB-TolC deficient Escherichia coli JW25113 after 18 to 24 hrs in absence of colistin by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID681142 | TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cells | 2002 | Molecular pharmacology, May, Volume: 61, Issue:5 | Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. |
| AID531579 | Antibacterial activity against Micrococcus spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1230065 | Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2372 assessed as inhibition of bacterial growth | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates. |
| AID411935 | Potentiation of electrical field stimulation-induced contraction in New Zealand white rabbit gastric antrum at 0.3 uM | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. |
| AID565033 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID569035 | Antimicrobial activity against penicillin-susceptible Staphylococcus aureus P1 by broth microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. |
| AID571488 | Antimicrobial activity against Campylobacter jejuni JL302 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID340859 | Antimicrobial activity against vancomycin-intermediate resistant Staphylococcus aureus Mu50 graR mutant microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. |
| AID554874 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 2678 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID586052 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type 2 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID545056 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate DL010 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID494444 | Antibacterial activity against Escherichia coli ATCC 7839 at 100 ug after 24 hrs by paper disc method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. |
| AID1327929 | Antibacterial activity against Micrococcus luteus ATCC 10240 at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID356438 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by agar dilution method | 2003 | Journal of natural products, Sep, Volume: 66, Issue:9 | Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericumatomarium ssp. degenii. |
| AID1240326 | Antibacterial activity against mexX, mexB deficient Pseudomonas aeruginosa NB52023-CDK005 harboring gyrAT83I by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID429852 | Antibacterial activity against Staphylococcus aureus RN4220 overexpressing MsrA after 24 hrs | 2009 | Journal of natural products, Jun, Volume: 72, Issue:6 | Antibacterial diterpenes from Plectranthus ernstii. |
| AID574722 | Upregulation of pyrR gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 24 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID150754 | Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID542606 | Antimicrobial activity against Pseudomonas aeruginosa H188 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID135360 | Plasma concentration of compound in mice by oral administration,20mg/kg at 1 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1447483 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate P264-104354 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID26629 | Dissociation constant (pKa) | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID326023 | Antimicrobial activity against Campylobacter jejuni S3BE8-1 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID571251 | Antimicrobial activity against Campylobacter jejuni DC10 harboring protein L4 G57D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID535642 | Antimicrobial activity against Group B streptococcus serotype VI N4 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID135495 | Plasma concentration of compound in mice by oral administration,20mg/kg at 2 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID206580 | In vitro antibacterial activity of A-5278 strain of Gram positive bacteria Staphylococcus aureus | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID278529 | Antimicrobial activity against Bifidobacterium longum R0175 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID565081 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus 152 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID208125 | In vitro inhibitory activity against Streptococcus pneumoniae (032UC1) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID532018 | Antibacterial activity against macrolide-lincosamide-streptogramin B-negative, beta-lactamase-positive, methicillin-susceptible Staphylococcus aureus ATCC 29213 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID278507 | Antibacterial activity against Pneumococcus CDC050 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID379527 | Antibacterial activity against Haemophilus influenzae ATCC 49247 | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11 | Acetylated flavanone glycosides from the rhizomes of Cyclosorus acuminatus. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID575146 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS123 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID670959 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 24 hrs by microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. |
| AID113637 | ED50 value was measured by sc administration against streptococcus pyogenes infection in mice (in vivo, in experiment 3) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1502707 | Antimycobacterial activity against Mycobacterium avium 104 mc'2 3 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID1225387 | Antibacterial activity against Escherichia coli AG102 overexpressing AcrAB-TolC by p-iodonitrotetrazolium chloride colorimetric assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp. |
| AID278492 | Antibacterial activity against Pneumococcus DAW57 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID547663 | Antibacterial activity against erythromycin-resistant Staphylococcus aureus 5676 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID721753 | Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells at 20 uM after 1.5 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. |
| AID112494 | In Vivo evaluation for its effective dose against Streptococcus pneumoniae (032UC1) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID571464 | Antimicrobial activity against Campylobacter jejuni DC39 harboring protein L4 G74D and G57V mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1055323 | Antibacterial activity against beta-lactamase producing Morganella morganii ATCC 25830 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID624623 | Apparent permeability (Papp) from basolateral to apical side determined in MDR1-MDCKII cells | 2001 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 299, Issue:2 | Rational use of in vitro P-glycoprotein assays in drug discovery. |
| AID529873 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring pAT392 containing mph(B) and rdmC-like genes by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID533879 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID562604 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID424845 | Inhibition of ribosomal activity in erythromycin-resistant Propionibacterium acnes GE4E carrying Erm(X) gene assessed as luciferase production by transcriptional and translational assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID202134 | In Vitro antibacterial ativity against Streptococcus pyogenes EES61 (Ery-S strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID560248 | Antibacterial activity against Staphylococcus aureus RN4220 harboring aadD, tet(L), dfrK and vga(C) gene by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID565006 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus epidermidis assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID765060 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 | Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. |
| AID562374 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus pyogenes clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID208785 | In vitro antibacterial activity against constitutively MLS B resistant Staphylococcus pneumoniae SR138 strain encoded by an ermB gene | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. |
| AID569036 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes S2 by broth microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. |
| AID529518 | Antibacterial activity against normal-colony variant Staphylococcus aureus derived from non cystic fibrosis patient assessed as resistant isolates at 37 degC after 24 hrs by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. |
| AID565076 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID533856 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium mucogenicum after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID245078 | Minimum inhibitory concentration against Staphylococcus aureus A5177 (erythromycin-resistant strain | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10 | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. |
| AID571444 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 by Etest method in presence of 2 ug/ml NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID208015 | In vitro antibacterial activity against PIU 2548 strain of Streptococcus pyogenes | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID326003 | Antimicrobial activity against Campylobacter jejuni 700819 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID347506 | Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID520611 | Antimicrobial activity against Group D Enterococcus faecium clinical isolate expressing erm(B) and erm(T) genes by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Prevalence of the erm(T) gene in clinical isolates of erythromycin-resistant group D Streptococcus and Enterococcus. |
| AID564823 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID279884 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 250 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID279875 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 250 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID574925 | Enhancement of biofilm formation Staphylococcus epidermidis SW082 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID113989 | Effective dose against mice infected with streptococcus pneumoniae after peroral administration (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID520083 | Antimicrobial activity against aheB-deficient kanamycin-resistant Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring AheABC efflux pump by agar dilution method in presence of 64 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID534106 | Antibacterial activity against Pasteurella multocida AL435 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID440235 | Inhibition of human ERG expressed in HEK cells at 30 uM | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety. |
| AID545050 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ250 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID19006 | Calculated membrane partition coefficient (Kmemb) | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7 | Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. |
| AID309833 | Antimicrobial activity against Escherichia coli NIHJ JC-2 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID534109 | Ratio of MIC for Pasteurella multocida AL435 to MIC for TolC deficient Pasteurella multocida pm0527 | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID519330 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT05 carrying rplD and rplV mutant genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID572062 | Antibacterial activity against abeS sigma abeS-deficient Acinetobacter baumannii AC0037 by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID681307 | TP_TRANSPORTER: increase in Vincristine intracellular accumulation (Vincristine: 0.03 uM, Erythromycin: 14.7 mg/mL) in HL60R cells: flow cytometric analysis | 2000 | Antimicrobial agents and chemotherapy, Jun, Volume: 44, Issue:6 | Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells. |
| AID323018 | Antibacterial activity against drug-resistant Propionibacterium acnes P95 after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID325017 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 859 isolate with erm(B) resistance gene from patient bronchoalveolar lavage by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID586047 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type 6 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID261787 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID279912 | Attenuation of Burkholderia pseudomallei KHW cytotoxicity in A549 cells at 128 ug/ml | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID717687 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 09U035 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID560499 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 5zjsau3 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1241213 | Ratio of Kd for 5'-FAM-pre-miR-372 (unknown origin) in presence of 100-fold excess of Escherichia coli tRNA to Kd for 5'-FAM-pre-miR-372 (unknown origin) | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID533663 | Antimicrobial activity against Staphylococcus aureus RN1024 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID1221980 | Transporter substrate index of efflux ratio in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID299389 | Antibacterial activity against Haemophilus influenzae OC4882 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID323030 | Antibacterial activity against Staphylococcus epidermidis after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID532020 | Antibacterial activity against macrolide-lincosamide-streptogramin B-negative, beta-lactamase-positive, methicillin-susceptible Staphylococcus aureus isolate 3 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID524827 | Antibacterial activity against erythromycin susceptible Campylobacter sp. assessed as resistance breakpoint by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID548475 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm, graRm mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID444056 | Fraction escaping gut-wall elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID678447 | Antibacterial activity against Pseudomonas aeruginosa at 12 ug/well after 24 hrs by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction. |
| AID562412 | Antimicrobial activity against Streptococcus Group G clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1532162 | 1,9-decadiene/aqueous buffer solution partition coefficient, log D of the compound in PBS at pH 7.4 by shake flask method | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24 | Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility. |
| AID1684998 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth incubated for 16 to 20 hrs by microdilution method | 2021 | ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1 | Enhancing Antimicrobial Peptide Potency through Multivalent Presentation on Coiled-Coil Nanofibrils. |
| AID1546173 | Antimicrobial activity against Klebsiella pneumoniae ATCC 700603 assessed as zone of inhibition at 100 ug/ml after 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID573133 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID562369 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group G clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278493 | Antibacterial activity against Pneumococcus DAW61 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID278537 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1762631 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15692 by CLSI based microplate assay | |||
| AID424758 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus MB2865 after 20 hrs by twofold serial broth dilution method in presence of 50% human serum | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID187379 | Plasma concentration in rats was determined by oral administration, 20 mg/kg at 5 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID694208 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22 | Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives. |
| AID369652 | Antibacterial activity against Campylobacter jejuni 001B-22 cmeB::kanamycin-resistant mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. |
| AID724502 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes RE clinical isolate by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID527494 | Octanol-water partition coefficient, log P of the compound | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents. |
| AID206740 | In vitro antibacterial activity against Staphylococcus aureus 1775 strain | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID206199 | MIC value measured against staphylococcus epidermidis 222 | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID405139 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate assessed as percent susceptible isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID574545 | Antimicrobial activity against community-associated methicillin-resistant Staphylococcus aureus USA300 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID323010 | Antibacterial activity against drug-resistant Propionibacterium acnes GE4E after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID326038 | Antimicrobial activity against Campylobacter coli MR32DE8-1 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1677807 | Antibacterial activity against Staphylococcus aureus ATCC25923 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID1137037 | Antimicrobial activity against Staphylococcus aureus ATCC 6538P by agar dilution method | 1977 | Journal of medicinal chemistry, May, Volume: 20, Issue:5 | Structure-activity relationships among the O-acyl derivatives of leucomycin. Correlation of minimal inhibitory concentrations with binding to Escherichia coli ribosomes. |
| AID1899687 | Bacteriolytic activity against Bacillus cereus ATCC 10987 incubated for 2 hrs | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action. |
| AID545054 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ390 from patient secretion by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID560521 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate xa07029 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID532989 | Antibacterial activity against Klebsiella aerogenes NCIM 2281 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID520609 | Antimicrobial activity against Group D Streptococcus sp. clinical isolates assessed as resistant isolates | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Prevalence of the erm(T) gene in clinical isolates of erythromycin-resistant group D Streptococcus and Enterococcus. |
| AID581463 | Antimicrobial activity against Escherichia coli TA531 harboring 23S rRNA A2058G mutant after 15 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID545052 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ363 from patient secretion by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID512996 | Antimicrobial activity against compound treated Staphylococcus aureus harboring mgrA C12S mutant gene retro-orbitally infected into mouse assessed as reduction in bacterial CFU in kidney at 10 ug/ml relative to control | 2006 | Nature chemical biology, Nov, Volume: 2, Issue:11 | An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. |
| AID706043 | Potency index, ratio of MBC to MIC for methicillin-sensitive Staphylococcus aureus 8325-4 | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. |
| AID288356 | Antibacterial activity against Haemophilus influenzae after 24 hrs by microdilution method | 2007 | Bioorganic & medicinal chemistry, Jul-01, Volume: 15, Issue:13 | Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides. |
| AID477409 | Antibacterial activity against Staphylococcus aureus NCTC 8325 after 16 to 20 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. |
| AID1594369 | Antibacterial activity against Klebsiella pneumoniae ATCC BAA-1705 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID619453 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae AB11 expressing erm and mef gene by the broth microdilution method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Novel C-4'' modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation. |
| AID520396 | Antibacterial activity against mef(E) and mef(A)-positive Streptococcus pneumoniae isolate CC-6B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID326042 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 2 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID326008 | Antimicrobial activity against Campylobacter coli RN14B with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID598137 | Antimicrobial activity against Staphylococcus aureus FDA209P by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID325011 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 460 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID530128 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID1677805 | Antibacterial activity against penicillin-resistant Staphylococcus aureus incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID571763 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-F628F mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID424767 | Antibacterial activity against vancomycin, linezolid-resistant Enterococcus faecium CL5791 after 20 hrs by twofold serial broth dilution method in presence of 50% human serum | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID1899689 | Bacteriolytic activity against Staphylococcus aureus LMG 8224 incubated for 2 hrs | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action. |
| AID326037 | Antimicrobial activity against Campylobacter coli MR32DE8-1 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID571468 | Antimicrobial activity against Campylobacter jejuni JL279 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID362545 | Antibacterial activity against epidemic methicillin-resistant Staphylococcus aureus 15 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID1677802 | Antibacterial activity against Pseudomonas aeruginosa ATCC27853 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID559767 | Antimycobacterial activity against Mycobacterium smegmatis harboring PknG Msm gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID739298 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition by CLSI broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. |
| AID574712 | Antimicrobial activity against Staphylococcus epidermidis SW036 assessed as enhancement of biofilm formation after 18 hrs by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID571243 | Antimicrobial activity against Campylobacter jejuni DC2 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID424850 | Antibacterial activity against erythromycin-resistant Propionibacterium acnes GE4E carrying Erm(X) gene | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID575102 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID68045 | In vitro antibacterial activity against erythromycin-susceptible Enterococcus faecalis ATCC 19434 strain | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. |
| AID207076 | In vitro inhibitory activity against Staphylococcus aureus (EryRc 011CB20) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID326006 | Antimicrobial activity against Campylobacter jejuni S3B with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID278991 | Antibacterial activity against Escherichia coli DH5-alpha containing pUC18 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. |
| AID278992 | Antibacterial activity against Escherichia coli DH5-alpha containing macrolide-resistant pUC18-mph(E) region | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. |
| AID208134 | In vitro minimum inhibitory concentration against Streptococcus pneumoniae 5649. | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID1355949 | Antimicrobial activity against Xanthomonas campestris pv. oryzae KB88 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID767509 | Antibacterial activity against Streptococcus pneumoniae 746 by standard dilution assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18 | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. |
| AID167005 | In vitro smooth muscle contractility using isolated rabbit duodenum | 1998 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 8, Issue:7 | Preparation of 9-deoxo-4"-deoxy-6,9-epoxyerythromycin lactams "motilactides": potent and orally active prokinetic agents. |
| AID1687311 | Antibacterial activity against wild type Escherichia coli BW25113 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID362543 | Antibacterial activity against tetracycline-resistant Staphylococcus aureus XU212 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID1870158 | Antibacterial activity against wild type Staphylococcus aureus 4788/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID19662 | Calculated partition coefficient (clogP) | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID544285 | Antimicrobial activity against Enterococcus faecalis NKH15 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID562222 | Antimicrobial activity against Desulfovibrio desulfuricans Essex 6 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID278684 | Antibacterial activity against Enterococcus faecalis isolate 5746 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID322994 | Antibacterial activity against drug-resistant Propionibacterium acnes OK8/97 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID278563 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID547537 | Antimicrobial activity against invasive Streptococcus anginosus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID586072 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB and vanA gene expressing Enterococcus faecium isolate A15 containing streptogramin A resistance genes vatG and vgaD isolated from poultry stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID557096 | Binding affinity to human alpha-1-acid glycoprotein assessed as compound binding sites level by SPR | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID584327 | Antibacterial activity against speE deficient Escherichia coli JW0117-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1217707 | Time dependent inhibition of CYP2C19 in human liver microsomes at 100 uM by LC/MS system | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID516167 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates assessed as resistant isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID276842 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4421 containing mef(A) | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID1153415 | Antimicrobial activity against Staphylococcus aureus MLS-16 MTCC 2940 assessed as inhibition of biofilm formation after 24 hrs by crystal violet staining-based assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID309821 | Antimicrobial activity against Staphylococcus aureus FDA209P by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID574918 | Enhancement of biofilm formation Staphylococcus epidermidis SW104 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID41265 | In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 111 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID1055333 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis W4138 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID323022 | MBC/MIC ratio of Propionibacterium acnes SW3CD | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID554872 | Antimicrobial activity against Streptococcus pneumoniae serotype 6B ST 3246 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID560518 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 15b52 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID458150 | Antimicrobial activity against Streptococcus mutans KCTC 3065 after 20 hrs by plate dilution method | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1194854 | Antimicrobial activity against Bacillus subtilis MTCC 121 assessed as inhibition of biofilm formation after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, May-01, Volume: 25, Issue:9 | One-pot catalyst free synthesis of novel kojic acid tagged 2-aryl/alkyl substituted-4H-chromenes and evaluation of their antimicrobial and anti-biofilm activities. |
| AID554877 | Antimicrobial activity against Streptococcus pneumoniae serotype 6B ST 138 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID534083 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID326044 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 3 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1542739 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 measured after 18 hrs by broth dilution method | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID718272 | Antimicrobial activity against Bacillus thuringiensis | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID718274 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID283559 | Antibacterial activity against Escherichia coli AG102MB after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID592683 | Apparent permeability from basolateral side to apical side of human Caco2 cells by LC/MS/MS analysis | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | QSAR-based permeability model for drug-like compounds. |
| AID595939 | Antibacterial activity against Bacillus subtilis | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Chemistry and biology of macrolide antiparasitic agents. |
| AID210221 | In vitro antibacterial activity against Streptococcus pneumoniae 5979 (MLSB resistant stain bearing an erm (B) gene) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID411932 | Potentiation of electrical field stimulation-induced contraction in New Zealand white rabbit gastric antrum at 10 uM | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. |
| AID1240327 | Antibacterial activity against mexX, mexB deficient Pseudomonas aeruginosa NB52023-CDK006 harboring gyrAT83I and parC S87L by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID554974 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as reduction in mature 23S rRNA at 100 ug/ml | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID547192 | Antibacterial activity against Campylobacter jejuni assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID562392 | Antimicrobial activity against Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID326019 | Antimicrobial activity against Campylobacter jejuni S3BE4-2 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID562522 | Antimicrobial activity against vancomycin-, gentamicin-resistant Enterococcus faecium TX1330RF-B2 conjugant expressing hylEfm gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID276849 | Antibacterial activity against Bacillus subtilis | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID508385 | Antibacterial activity against Streptococcus pyogenes harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID544528 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID717675 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 09U070 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID326014 | Antimicrobial activity against Campylobacter coli AW-II-37 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID535636 | Antimicrobial activity against Group B streptococcus serotype VI R4 harboring Q557E mutation in PBP 2X and T567I, Y262N mutations in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID562367 | Antimicrobial activity against Streptococcus Group F clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID565010 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID23096 | The negative logarithm of the fraction of neutral molecules | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID404897 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB30 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID571505 | Antimicrobial activity against compound-resistant Campylobacter jejuni | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1221978 | Transporter substrate index ratio of permeability from apical to basolateral side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID573154 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID279865 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 500 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID279864 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 1000 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID279898 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 500 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID559762 | Antimycobacterial activity against Mycobacterium smegmatis MAR4 harboring disrupted PknGMsm gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID21658 | Calculated partition coefficient (clogP) | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID263386 | Antibacterial activity against Staphylococcus aureus Smith OC4172 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID532986 | Antibacterial activity against Pseudomonas aeruginosa NCIM 5029 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID586042 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type U3 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID201260 | In Vitro antibacterial activity against Staphylococcus aureus A5177 (ermA-i strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID598146 | Antimicrobial activity against Serratia marcescens IFO12648 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID519481 | Antibacterial activity against Staphylococcus aureus T991 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID1888848 | Antibacterial activity against Staphylococcus aureus K1758 measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID325444 | Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID571263 | Antimicrobial activity against Campylobacter jejuni DC22 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID423267 | Antibacterial activity against azithromycin-resistant 0.01 MOI Chlamydia psittaci 6BC BCRBAZ5 harboring A2059C mutation in bacterial 23S rRNA gene infected in mouse L2 cells treated 2 hrs after infection measured on day 7 by plaque assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. |
| AID565760 | Antimicrobial activity against oxacillin-susceptible Staphylococcus aureus clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID535570 | Antibacterial activity against Salmonella enterica serovar montevideo harboring rlpD GC379T and rlpV G25A mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro activity of azithromycin against nontyphoidal Salmonella enterica. |
| AID1474192 | Antibacterial activity against Klebsiella pneumoniae BAA-1706 after 18 to 22 hrs in absence of colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID717686 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 09L075 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID571265 | Antimicrobial activity against Campylobacter jejuni DC24 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID717678 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 09H071 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID530125 | Antimicrobial activity against community acquired methicillin-resistant Staphylococcus aureus 146 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID529519 | Antibacterial activity against normal-colony variant Staphylococcus aureus derived from cystic fibrosis patient assessed as resistant isolates at 37 degC after 24 hrs by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. |
| AID261783 | Antibacterial activity against macrolide resistant Streptococcus pneumoniae ATCC 700676 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID323008 | Antibacterial activity against drug-resistant Propionibacterium acnes GE46EB after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID564811 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus haemolyticus assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID548471 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID375938 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 hrs by broth microdilution method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4 | Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens. |
| AID565013 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus simulans assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1447478 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID326035 | Antimicrobial activity against Campylobacter coli MR32DE4-1 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID523012 | Ratio of Kcat to Km for macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID559770 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 4sy32 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID369649 | Antibacterial activity against Campylobacter jejuni 001B-22 carrying A2075G mutation in 23S rRNA by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. |
| AID547195 | Antibacterial activity against Campylobacter coli assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea. |
| AID41431 | In vitro antimicrobial activity against anaerobic bacteria bacteroides thetaiotaomicron 1438 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID557092 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method in presence of 50% human serum | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID206106 | In vitro antimicrobial activity against aerobic bacteria Streptococcus G Kruder | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID325009 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 427 isolate with erm(B) resistance gene from patient sinuitis by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID559763 | Antimycobacterial activity against Mycobacterium smegmatis MC2 155 harboring PknG K181M mutant gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID1393954 | Antibacterial activity against linezolid/methicillin resistant Staphylococcus aureus NR 45926 after 16 to 20 hrs by CLSI method | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16 | 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. |
| AID1240325 | Antibacterial activity against Pseudomonas aeruginosa K1542 deficient with mexX, mexB by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID571248 | Antimicrobial activity against Campylobacter jejuni DC7 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID411667 | Antibacterial activity against MLSB-resistant Staphylococcus aureus 27660 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID520607 | Antimicrobial activity against Group D Streptococcus sp. clinical isolates expressing erm(T) gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Prevalence of the erm(T) gene in clinical isolates of erythromycin-resistant group D Streptococcus and Enterococcus. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID187372 | Plasma concentration in rats was determined by oral administration, 20 mg/kg at 1 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID279871 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 7.8 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID727096 | Antibacterial activity against Enterobacter aerogenes Ea289 after 18 hrs by broth dilution method | 2013 | Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5 | Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant gram-negative bacteria. |
| AID396030 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP2 plasmid containing Enterobacter cloacae acrA gene by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID681138 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cells | 2002 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 303, Issue:1 | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. |
| AID1355958 | Antimicrobial activity against Mucor racemosus KF223 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID586038 | Antimicrobial activity against Staphylococcus aureus clone 1-1 harboring staphylococcal cassette chromosome mec element type U assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID530759 | Induction of PsgtB::lacZ gene expression in Staphylococcus aureus SH1000 at 2.5 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials. |
| AID369231 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pneumoniae isolates by double-disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID548473 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSn mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID540216 | Clearance in dog after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID279899 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 250 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID560512 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b6k1642 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID571460 | Antimicrobial activity against Campylobacter jejuni DC35 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID604042 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae A22072 expressing mef gene by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Synthesis and antibacterial activity of novel 4″-O-benzimidazolyl clarithromycin derivatives. |
| AID209607 | In vitro antibacterial activity against Streptococcus pyogenes strain 930. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID554660 | Antimicrobial activity against Ureaplasma parvum SV9 containing tetM gene | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID574937 | Antimicrobial activity against Staphylococcus epidermidis lacking compound-induced biofilms assessed as biofilm formation at 1/4 X MIC relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID157250 | In vitro antimicrobial activity against anaerobic bacteria peptococcus prevoti 1281 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID279882 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 1000 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID573148 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID323028 | Antibacterial activity against Corynebacterium amycolatum after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID278531 | Antimicrobial activity against Bifidobacterium pseudolongum ATCC 25562 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID717272 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 by CLSI protocol based broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives. |
| AID571458 | Antimicrobial activity against Campylobacter jejuni DC33 harboring 23S rRNA A2074G mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID424323 | Antimicrobial activity against Dialister pneumosintes assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID544278 | Antimicrobial activity against Enterococcus faecalis NKH8 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID554878 | Antimicrobial activity against Streptococcus pneumoniae serotype 10 ST 461 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID311524 | Oral bioavailability in human | 2007 | Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24 | Hologram QSAR model for the prediction of human oral bioavailability. |
| AID512011 | Antibacterial activity against ampicillin-resistant Haemophilus influenzae 3300 by broth microdilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: a novel class of acylides. |
| AID534085 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID1596576 | Antibacterial activity against Klebsiella pneumoniae BAA-1706 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID83797 | In vitro antibacterial activity against ampicillin resistant Haemophilus influenzae 33929 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. |
| AID208136 | In vitro minimum inhibitory concentration against Streptococcus pneumoniae ATCC 6303. | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID279891 | Attenuation of A549 cell invasion by Burkholderia pseudomallei KHW at 8 ug/ml in presence of 250 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID518962 | Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZ7 lacking codons 2 to 4 with additional mutations leader peptide cistrons reporter plasmid at 25 mg/ml after 36 hrs at 37 degC by disc-based be | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID545046 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ085 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID584123 | Antimicrobial activity against Staphylococcus aureus RN4220 carrying pAFS11-apmA, erm(B), tet(L), dfrK, aadD resistance genes by CLSI M31-A3 method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. |
| AID1211812 | Drug excretion in iv dosed human assessed as compound excreted into bile after 20 hrs | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID575077 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID279908 | Attenuation of Burkholderia pseudomallei KHW cytotoxicity in A549 cells at 8 ug/ml in presence of 250 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID45400 | Effect on cross resistance of CHO cells resistant to colchicine (CHRC5) | 1990 | Journal of medicinal chemistry, Jul, Volume: 33, Issue:7 | Structure-activity relationships of antineoplastic agents in multidrug resistance. |
| AID678740 | TP_TRANSPORTER: inhibition of Vinblastine efflux (Vinblastine: 0.002 uM, Erythromycin:100 uM) in P388/S and P388/ADR cells | 2000 | Clinical and experimental pharmacology & physiology, Aug, Volume: 27, Issue:8 | Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo. |
| AID739305 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 8325-4 assessed as growth inhibition by CLSI broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7 | Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. |
| AID524898 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B resistant and erm(B)-positive Streptococcus pneumoniae by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. |
| AID1240323 | Antibacterial activity against fluoroquinolone-resistant Staphylococcus aureus NB01006-AVR005 harboring gyrA S84L, parC S80F, parE E471K by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID261800 | Antibacterial activity against Haemophilus influenzae EH003 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID681130 | TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing MDCKII cells | 2001 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 299, Issue:2 | Rational use of in vitro P-glycoprotein assays in drug discovery. |
| AID278523 | Antimicrobial activity against Bifidobacterium bifidum ATCC 15696 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID161937 | In vitro inhibitory activity against Pneumococci EryRc (34) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID529876 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring pAT392 containing mph(B) and rdmC-like gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID571432 | Antibacterial activity against Escherichia coli ATCC 25992 by Etest method in presence of 1 ug/ml NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID574932 | Effect on polysaccharide secretion in Staphylococcus epidermidis SW029 expressing icaA gene at 12 hrs by SEM | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID1474198 | Antibacterial activity against Escherichia coli O157:H7 ATCC 35150 after 18 to 22 hrs in presence of 1/4 times MIC colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID562600 | Antimicrobial activity against oxacillin-resistant Staphylococcus epidermidis clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID261782 | Antibacterial activity against Streptococcus pneumoniae ATCC 700671 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID187375 | Plasma concentration in rats was determined by oral administration, 20 mg/kg at 2 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID560517 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate 07b63 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID588121 | Antimicrobial activity against Streptococcus suis UD isolated from cerebrospinal fluid of patient with meningitis by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis. |
| AID41267 | In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 1936B, | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID279911 | Attenuation of Burkholderia pseudomallei KHW cytotoxicity in THP1 cells at 8 ug/ml in presence of 500 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID544288 | Antimicrobial activity against Enterococcus faecalis NKH18 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID203440 | In vitro inhibitory activity against Staphylococci EryRc (23) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID571766 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB-N616 mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID278993 | Antibacterial activity against Escherichia coli DH5-alpha containing macrolide-resistant pUC18-mrx(E) region | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. |
| AID575099 | Antimicrobial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID512010 | Antibacterial activity against ampicillin-susceptible Haemophilus influenzae ATCC 49247 by broth microdilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: a novel class of acylides. |
| AID24865 | The negative logarithm of the fraction of singly charged molecules. | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID534424 | Antibacterial activity against Mycobacterium bovis BCG-Pasteur | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics. |
| AID1729225 | Antibacterial activity against multidrug-resistant Escherichia coli BW25113 harboring AcrB deletion mutant by two-fold broth dilution method | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and structural optimization of novel 2H-benzo[h]chromene derivatives that target AcrB and reverse bacterial multidrug resistance. |
| AID1355948 | Antimicrobial activity against Pseudomonas aeruginosa KB359 NBRC 12582 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID1525337 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID534345 | Antimicrobial activity against Burkholderia pseudomallei Bp175 harboring mini-Tn7T-P1-bpeR+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID498882 | Antimicrobial activity against Escherichia cloi RAM4100 transfected with pNK1 containg Neisseria meningitidis tolC gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID530429 | Resistance factor, ratio of MIC for Mycobacterium smegmatis overexpressing rv0194 gene to MIC for wild-type Mycobacterium smegmatis SMR5 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis. |
| AID571269 | Antimicrobial activity against Campylobacter jejuni DC28 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1888846 | Antibacterial activity against Staphylococcus aureus 1199B measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID509632 | Antimicrobial activity against Staphylococcus aureus 25 transformant carrying plasmid pKKS25 and expressing erm(T), dfrKtet(L), tet(K), tet(M), mecA and blaZ genes by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID278534 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID571928 | Ratio of MIC for Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB mutant gene to MIC for Escherichia coli K-12 3-AG300 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID519665 | Inhibition of PAR2-mediated SLIGKV-NH2-induced interleukin-8 production in normal human epidermal keratinocytes at 10 uM preincubated for 24 hrs by ELISA | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. |
| AID571448 | Antibacterial activity against Enterobacter cloacae ATCC 23355 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID187384 | Plasma concentration in rats was determined by subcutaneous administration, 20 mg/kg at 1 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID278554 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID283554 | Antimicrobial activity against Streptococcus pneumoniae PC13 isolate with L4 69GTG71 to TPS mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID360380 | Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake | 2007 | The Journal of biological chemistry, Jan-26, Volume: 282, Issue:4 | In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. |
| AID206930 | In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus 513E | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID1176913 | Antibacterial activity against Pseudomonas aeruginosa assessed as growth inhibition at 50 ug/ml after 24 hrs by microplate reader analysis | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Synthesis and anti-biofilm activities of dihydro-pyrrol-2-one derivatives on Pseudomonas aeruginosa. |
| AID1542738 | Antibacterial activity against Escherichia coli ATCC 25922 measured after 18 hrs by broth dilution method | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID278478 | Antibacterial activity against Pneumococcus DAW6 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID574914 | Enhancement of biofilm formation Staphylococcus epidermidis SW061 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID533661 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring plasmid CU1 | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID557094 | Antimicrobial activity against Staphylococcus aureus CIP 76.25 by microdilution method in presence of 1.6% gamma globulin | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID510750 | Antibacterial activity against Escherichia coli AG102MB harboring pS1328-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID574547 | Increase in PSMalpha levels in Staphylococcus aureus USA300 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID1326849 | Antibacterial activity against Streptococcus pneumoniae CL2883 by broth microdilution technique | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | A Gestalt approach to Gram-negative entry. |
| AID208135 | In vitro minimum inhibitory concentration against Streptococcus pneumoniae 5737. | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID527725 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae ATCC 6301 | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. |
| AID16672 | Percentage ionization was measured | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | A comparative NMR study between the macrolide antibiotic roxithromycin and erythromycin A with different biological properties. |
| AID297186 | Antibacterial activity against multidrug resistant Staphylococcus aureus 49589 | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms. |
| AID326066 | Antimicrobial activity against Streptococcus pneumoniae NMU112 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID678715 | Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID1055325 | Antibacterial activity against New Delhi metallo-beta-lactamase 1 producing Klebsiella pneumoniae ATCC BAA-2146 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID588114 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates assessed as percent susceptible isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID554879 | Antimicrobial activity against Streptococcus pneumoniae serotype 17 ST 3248 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID554652 | Antimicrobial activity against Ureaplasma parvum SV1 isolate HPA18 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID520423 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU18 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID1516024 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID428244 | Increase in lag phase of growth for telithromycin-resistant Streptococcus pneumoniae isolate P1501016 assessed as doubling time at 1 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID411933 | Potentiation of electrical field stimulation-induced contraction in New Zealand white rabbit gastric antrum at 3 uM | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. |
| AID278530 | Antimicrobial activity against Bifidobacterium longum P/N 601377 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID524899 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B resistant erm(B) and mef(E)-positive Streptococcus pneumoniae by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. |
| AID573127 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID585878 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 2 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID1542753 | Potentiation of erythromycin-induced antibacterial activity against Escherichia coli ATCC 25922 assessed as concentration required to restore 2 ug/ml erythromycin activity measured after 18 hrs | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | 6-Bromoindolglyoxylamido derivatives as antimicrobial agents and antibiotic enhancers. |
| AID210391 | MIC value measured against streptococcus pyogenes C203 | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1594141 | Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme acti | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID564815 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus epidermidis assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID323031 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID150755 | Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1594366 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID562585 | Antimicrobial activity against erythromycin-susceptible Streptococcus agalactiae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID368419 | Antimicrobial activity against Escherichia coli KAM32 expressing deltaacrB ydhE hsd gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID575143 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate NRS70 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID524895 | Antibacterial activity against macrolide resistant and mef(I)-positive Streptococcus pneumoniae by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. |
| AID574921 | Enhancement of biofilm formation Staphylococcus epidermidis SW021 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID520006 | Antimicrobial activity against Chlamydia trachomatis isolated from human respiratory tract by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID424849 | Antibacterial activity against erythromycin-resistant Propionibacterium acnes SW54EA with 23S rRNA A2058G mutant | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID554976 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as reduction in mature 23S rRNA at 100 ug/ml in presence of E-peptide | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID1762628 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 by CLSI based microplate assay | |||
| AID535646 | Antimicrobial activity against Group B Streptococcus serotype III NEM 316 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID547658 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 5158 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID262170 | Antibacterial activity against macrolide-sensitive Escherichia coli HN818 | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Synthesis and biological investigation of new 4''-malonyl tethered derivatives of erythromycin and clarithromycin. |
| AID206933 | In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V41 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID278876 | Antiproliferative effect against primary human osteoblasts in presence of 10% FCS | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID1331169 | Antimicrobial activity against Staphylococcus epidermidis PP62A after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID586043 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type U5 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID210412 | In vitro antimicrobial activity against aerobic bacteria Streptococcus sanguis MX132 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID206747 | In vitro antibacterial activity against Staphylococcus aureus strain A 5177. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID318649 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID525041 | Antimicrobial activity against fluoroquinolone-resistant Escherichia coli NorE5 harboring GyrA S83L mutant, ParC S80R mutant, truncated SoxR and constitutively active SoxS by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. |
| AID1687313 | Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 1706 in presence of 0.25 times MIC of colistin incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID409959 | Inhibition of bovine liver MAOB | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21 | Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
| AID571465 | Antimicrobial activity against Campylobacter jejuni JL276 selected at 4 ug/ml after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID548474 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID678716 | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID519328 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT02 carrying duplication in the carboxy-terminal region of L22 ribosomal protein | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID529301 | Antimicrobial activity against Enterococcus faecalis expressing rRNA methylase gene erm(A) obtained from pig manure by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Detection of the erythromycin rRNA methylase gene erm(A) in Enterococcus faecalis. |
| AID278544 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1447485 | Antibacterial activity against multidrug/extremely drug-resistant/colistin-resistant Pseudomonas aeruginosa isolate 101243 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID520082 | Antimicrobial activity against aheB deficient kanamycin-resistant Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring AheABC efflux pump by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID278679 | Antibacterial activity against Enterococcus faecium isolate 5750 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID424420 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus HIP14300 isolated from patients foot wound by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID1361120 | Bacteriostatic activity against Acinetobacter baumannii ATCC 19606 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID508693 | Induction of spa virulent gene expression in Staphylococcus aureus PC203 containing spa::lacZ assessed as color chage at 5 ug/ml at 37 degC in presence of chromogenic beta-galactosidase substrate and 1 to 50 % glucose solution | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Method for screening compounds that influence virulence gene expression in Staphylococcus aureus. |
| AID278560 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID557103 | Binding affinity to human serum albumin assessed as fraction of binding sites occupied by compound at 146 to 220 ug/ml by SPR | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID276837 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus Smith OC4172 | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID1055343 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 09-6 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID67272 | Minimum inhibitory concentration against Streptococcus pyogenes EES 61 Ery-S | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID554657 | Antimicrobial activity against Ureaplasma parvum SV1 isolate UHWO10 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID557097 | Protein binding in serum | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID498879 | Antimicrobial activity against Escherichia cloi RAM1129 transfected with pGCC4 containg IPTG-inducible lacZ promoter by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID560504 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate bd4768 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1176915 | Antibiofilm activity against Pseudomonas aeruginosa at 50 ug/ml after 24 hrs by microplate reader analysis | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Synthesis and anti-biofilm activities of dihydro-pyrrol-2-one derivatives on Pseudomonas aeruginosa. |
| AID1397458 | Half life in pH 6.5 fasted state simulated intestinal fluid | 2018 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 28, Issue:17 | Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors. |
| AID528709 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID428235 | Increase in erm(B) mRNA expression in wild type Streptococcus pneumoniae PC13 at 0.25 ug/ml by qRT-PCR relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID584114 | Antibacterial activity against Escherichia coli KAM32 harboring Staphylococcus aureus cloned pSP72 lmrS by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID452746 | Antibacterial activity against fabI-overexpressing Escherichia coli M15 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1 | Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. |
| AID187387 | Plasma concentration in rats was determined by subcutaneous administration, 20 mg/kg at 20 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID542602 | Antimicrobial activity against Staphylococcus aureus ATCC 49525 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID562398 | Antimicrobial activity against Staphylococcus aureus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID585879 | Antimicrobial activity against Staphylococcus aureus clone 1-1 harboring staphylococcal cassette chromosome mec element type 5 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID168682 | Fluid concentration in liver tissue was determined in rats at 6 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID584326 | Antibacterial activity against tolC deficient Escherichia coli GD100 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID285833 | Antibacterial activity against erythromycin-resistant Campylobacter jejuni isolates by agar dilution test | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Comparison of disk diffusion and agar dilution methods for erythromycin and ciprofloxacin susceptibility testing of Campylobacter jejuni subsp. jejuni. |
| AID619456 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 29213 by the broth microdilution method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Novel C-4'' modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation. |
| AID209624 | In vitro minimum inhibitory concentration against Streptococcus pyogenes 930 using standard agar dilution method | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID1240314 | Antibacterial activity against wild type Escherichia coli ATCC 25922 by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID276852 | Inhibition of LPS-induced IL1-beta release in human PBMC at 10 uM relative to cyclohexane | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID51000 | In vitro antimicrobial activity against anaerobic bacteria clostridium perfringens 81, | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID535639 | Antimicrobial activity against Group B streptococcus serotype VI R1 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID547661 | Antibacterial activity against erythromycin-resistant Staphylococcus aureus AD-08 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID326068 | Antimicrobial activity against Streptococcus pneumoniae NMU605 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID619455 | Antibacterial activity against penicillin-resistant Staphylococcus aureus by the broth microdilution method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Novel C-4'' modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation. |
| AID1602921 | Efflux ratio of apparent permeability in human Caco2 cells at 5 uM after 90 mins | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. |
| AID260946 | Antibacterial activity against Streptococcus pneumoniae OC9132 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID560505 | Antimicrobial activity against SCCmec type II vancomycin-intermediate Staphylococcus aureus isolate b2k4781 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID210389 | In vitro antibacterial activity against Streptococcus pneumoniae strain ATCC 6303. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID561727 | Antibacterial activity against Enterococcus faecium assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID206581 | In vitro antibacterial activity of A5177 strain of Gram positive bacteria Staphylococcus aureus | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID283558 | Antibacterial activity against Escherichia coli AG102 with marR1 mutation after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID574552 | Decrease in delta toxin levels in Staphylococcus aureus USA300 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID1211877 | Unbound biliary clearance in Wistar rat at 10 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID1474201 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 18 to 22 hrs in presence of 1/4 times MIC colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID168685 | Fluid concentration in lung tissue was determined in rats at 2 h | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID278494 | Antibacterial activity against Pneumococcus DAW62 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID208289 | Minimum inhibitory concentration against Streptococcus pneumoniae 5737 MLSB | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID113493 | ED50 value was measured by po administration against staphylococcus aureus infection in mice (in vivo, in experiment 3) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1261118 | Antibacterial activity against clinically isolated erythromycin-susceptible Streptococcus pyogenes S2 by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID575103 | Antimicrobial activity against Streptococcus pneumoniae serotype 23A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID565191 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 expressing open reading frame orf3 encoded efflux pump CraA by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. |
| AID1870148 | Antibacterial activity against wild type Staphylococcus aureus 4566/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID528711 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus saprophyticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID95914 | Antibacterial activity against Klebsiella pneumoniae ATCC 10031 | 1987 | Journal of medicinal chemistry, Nov, Volume: 30, Issue:11 | Macrolides with gastrointestinal motor stimulating activity. |
| AID571445 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 by Etest method in presence of 4 ug/ml NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID545049 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ249 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID576111 | Antimicrobial activity against mecA-deficient Staphylococcus sciuri harboring staphylococcus aureus mecA gene assessed as resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. |
| AID1870123 | Antibacterial activity against antibiotic resistant Staphylococcus aureus 4740/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID326056 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 9 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID588120 | Antimicrobial activity against Streptococcus suis CA isolated from cerebrospinal fluid of patient with meningitis by broth microdilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis. |
| AID323014 | Antibacterial activity against drug-resistant Propionibacterium acnes QK6/92 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID694207 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis ATCC 19433 by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22 | Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives. |
| AID326004 | Antimicrobial activity against Campylobacter jejuni 700819 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID562390 | Antimicrobial activity against oxacillin-resistant Staphylococcus haemolyticus clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID638883 | Antibacterial activity against Streptococcus pneumoniae 49619 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1516021 | Antibacterial activity against Salmonella enterica serovar typhimurium C77-31 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1739432 | Permeability across apical to basolateral side in human Caco-2 cells assessed as luciferase yellow leakage at 10 uM incubated for 2 hrs LC-MS/MS analysis | 2020 | European journal of medicinal chemistry, Aug-15, Volume: 200 | Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. |
| AID1687308 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 to 20 hrs by broth microdilution method | 2020 | European journal of medicinal chemistry, Jan-15, Volume: 186 | Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. |
| AID524897 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B resistant and erm(B)-positive Streptococcus pneumoniae by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. |
| AID68698 | In vitro inhibitory activity against Escherichia coli (250 UC5) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID117681 | Protective dose at which 50% of infected, treated mice survive | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID1555434 | Antibacterial activity against Proteus vulgaris assessed as diameter of zone of inhibition at 15 ug/disc by disc diffusion method | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper. |
| AID586055 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type U3 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID1221966 | Ratio of plasma AUC in po dosed mdr1 knock out mouse to plasma AUC in po dosed wild type mouse | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID326024 | Antimicrobial activity against Campylobacter jejuni S3BE8-1 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID41559 | In vitro antimicrobial activity against anaerobic bacteria bacteroides vulgatus 1211 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID574935 | Antimicrobial activity against compound pretreated Staphylococcus epidermidis assessed as biofilm formation at 1/4 X MIC relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID288352 | Antibacterial activity against Streptococcus pneumoniae after 24 hrs by microdilution method | 2007 | Bioorganic & medicinal chemistry, Jul-01, Volume: 15, Issue:13 | Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides. |
| AID575169 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 1000 uM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID1591540 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID576339 | Antimicrobial activity against Chlamydia trachomatis serovar I infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID1502708 | Antimycobacterial activity against Mycobacterium avium 104 mc'2 4 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID562605 | Antimicrobial activity against Staphylococcus aureus clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1685708 | Antimicrobial activity against Bacillus subtilis assessed as inhibition of bacterial growth incubated for overnight by CLSI method | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12 | Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. |
| AID285847 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes B-83 transconjugated with erm(B) and tet(M) genes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene. |
| AID543827 | Antimicrobial activity against Borrelia spielmanii A14S after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID206579 | In vitro antibacterial activity of 6538P strain of Gram positive bacteria Staphylococcus aureus | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID535635 | Antimicrobial activity against Group B streptococcus serotype VI R5 harboring F395L, V405A, R433H, H438Y, and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID1870152 | Antibacterial activity against wild type Staphylococcus aureus 4738/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID424761 | Antibacterial activity against vancomycin-intermediate, macrolide, methicillin-resistant Staphylococcus aureus CL5706 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID424760 | Antibacterial activity against macrolide, methicillin-resistant Staphylococcus aureus CL5705 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID576342 | Bactericidal activity against Chlamydia trachomatis serovar D infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID584344 | Antibacterial activity against kanamycin-resistant acrAB, acrEF deficient Escherichia coli W4680AE presence of 15 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID210388 | In vitro antibacterial activity against Streptococcus pneumoniae strain 5737. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID323023 | MBC/MIC ratio of Propionibacterium acnes P95 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID518974 | Antimicrobial activity against Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID534317 | Antimicrobial activity against wild-type Streptococcus pneumoniae GA17457 expressing PmefE-lacZ gene induced by pretreatment with 1 ug/ml of compound for 1 hr by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae. |
| AID278990 | Antibacterial activity against Pseudomonas sp. B13 GFP1 containing macrolide resistance plasmid pRSB111 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. |
| AID548257 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm, graRm mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID586075 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB gene expressing Enterococcus faecium isolate JS79 containing streptogramin A resistance genes vatG and vgaD isolated from healthy human stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID168670 | Fluid concentration in kidney tissue was determined in rats at 2 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID424321 | Antimicrobial activity against Dialister pneumosintes assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID565229 | Antimicrobial activity against Mycobacterium chelonae ATCC 35752 harboring pZS01 carrying mspA gene by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID724507 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae AB11 expressing erm and mef genes by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID404896 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB28 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID547666 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 29213 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID519670 | Toxicity in normal human epidermal keratinocytes assessed as effect on cell viability at 10 uM after 72 hrs by colorimetric assay | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. |
| AID426102 | Growth inhibition of Pseudomonas aeruginosa PAO1 assessed as survival rate at 3.75 ug/mL after 20 hrs | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and evaluation of antibacterial activities of andrographolide analogues. |
| AID1176917 | Inhibition of MDH in Pseudomonas aeruginosa biofilm after 48 hrs by UV-spectrophotometry | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | Synthesis and anti-biofilm activities of dihydro-pyrrol-2-one derivatives on Pseudomonas aeruginosa. |
| AID519333 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT10 carrying rplD and rplV mutant genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID562368 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group G clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278567 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID86126 | In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae MX366, | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID637556 | Antibacterial activity against Moraxella catarrhalis 8176 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID208778 | In vitro antibacterial activity against erythromycin susceptible Streptococcus pneumoniae 49619 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin. |
| AID717676 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 09E427 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID571498 | Antimicrobial activity against Campylobacter jejuni DC2 infected in 15 days old chicken by agar dilution method in presence of feed with tylosin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID86120 | In vitro antibacterial activity against Haemophilus influenzae strain DILL. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID278491 | Antibacterial activity against Pneumococcus DAW53 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID561745 | Antibacterial activity against Methicillin-sensitive Staphylococcus aureus assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID561734 | Antibacterial activity against Beta-hemolytic Streptococcus group B assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID135359 | Plasma concentration of compound in mice by oral administration, 20 mg/kg at 4 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID325024 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 1051 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID458153 | Antimicrobial activity against Streptococcus sanguinis NCTC 9811 assessed as total bacterial adherence inhibition | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID547667 | Antibacterial activity against erythromycin-resistant Haemophilus influenzae 2412 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID168674 | Fluid concentration in kidney tissue was determined in rats at 6 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID598144 | Antimicrobial activity against Escherichia coli NIHJ JC-2 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID1899686 | Bacteriolytic activity against Escherichia coli LMG 8223 incubated for 2 hrs | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action. |
| AID356439 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by agar dilution method | 2003 | Journal of natural products, Sep, Volume: 66, Issue:9 | Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericumatomarium ssp. degenii. |
| AID318644 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus FDA 209P by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID530580 | Antimicrobial activity against Mycoplasma pneumoniae isolate FH by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID554869 | Antimicrobial activity against Streptococcus pneumoniae serotype 23F ST 961 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID278542 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID571884 | Antibacterial activity against Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID1544293 | Selectivity index, ratio of CC50 for African green monkey Vero cells to MIC for multi drug resistant Enterococcus faecium NCTC 7171 | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11 | Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens. |
| AID528712 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus hominis subsp. novobiosepticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID404304 | Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control | 2008 | Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11 | Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). |
| AID135498 | Plasma concentration of compound in mice by oral administration,20mg/kg at 5 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID404902 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID1424070 | In-vitro inhibition of protein translation using pY71-sfGFP in PUREexpress in vitro protein synthesis system assessed as reduction in cell-free GFP protein translation at 50 uM measured every 20 mins for 2 hrs | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. |
| AID574170 | Antibacterial activity against Escherichia coli MG1655 grown as biofilms harboring plasmid pBR322 carrying blaTEM-1 and tetA(C) genes after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. |
| AID589158 | Mechanism based inhibition of human cytochrome P450 3A4 measured by triazolam 4- hydroxylation using human liver microsomes | 2005 | Current drug metabolism, Oct, Volume: 6, Issue:5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
| AID325987 | Antimicrobial activity against Streptococcus sp. 782/96 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci. |
| AID571930 | Ratio of MIC for Escherichia coli K-12 3-AG300 harboring AcrB-G616N mutant gene to MIC for Escherichia coli K-12 3-AG300 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID728673 | Antimicrobial activity against hldE-deficient Escherichia coli O18:K1:H7 after overnight incubation | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence. |
| AID86128 | In vitro inhibitory activity against Haemophilus influenzae (351HT3) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID128090 | Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 2 hr; No detectable concentration of antibiotic | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID560222 | Antibacterial activity against Salmonella enterica serovar Typhimurium 01-4 by CLSI M7-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID584333 | Antibacterial activity against wild type Escherichia coli BW25113 absence of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID544286 | Antimicrobial activity against Enterococcus faecalis NKH16 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID388081 | Antifungal activity at Candida albicans | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID369665 | Ratio of MIC for Campylobacter jejuni 001B-40 carrying A2075G mutation in 23S rRNA to MIC for Campylobacter jejuni 001B-40 cmeB::kanamycin-resistant mutant | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. |
| AID525143 | Antimicrobial activity against linezolid-resistant Staphylococcus aureus isolate 004-737X expressing cfr and ermA gene isolated from paraplegic patient by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. |
| AID576336 | Antimicrobial activity against Chlamydia trachomatis serovar F infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID112492 | In Vivo evaluation for its effective dose against Streptococcus pneumoniae (030SJ1 EryRc) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID573135 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID348715 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes 19615 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID531634 | Bactericidal activity against Mycoplasma pneumoniae at 8 X MIC after 120 hrs | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. |
| AID325014 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 683 isolate with erm(B) resistance gene from patient sputum by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID571261 | Antimicrobial activity against Campylobacter jejuni DC20 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID510748 | Antibacterial activity against Escherichia coli AG102MB harboring naive acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID85792 | In vitro inhibitory activity against Haemophilus AmpR (37) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID369648 | Antibacterial activity against Campylobacter jejuni UA709 carrying A2074C mutation in 23S rRNA by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. |
| AID279900 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 125 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID528713 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus haemolyticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1516026 | Antibacterial activity against Acinetobacter baumannii AB1901 clinical isolate incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID1596578 | Bactericidal activity against Acinetobacter baumannii ATCC 19606 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID562402 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID565038 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus haemolyticus assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1221982 | Fraction absorbed in human | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID85983 | In vitro antibacterial activity of DILL strain of Gram positive bacteria Haemophilus influenzae | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID520873 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU69 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID728674 | Antimicrobial activity against wild type Escherichia coli O18:K1:H7 after overnight incubation | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence. |
| AID584116 | Ratio of MIC for Escherichia coli KAM32 harboring cloned pSP72 lmrS to MIC for Escherichia coli KAM32 harboring pSP72 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID574554 | Decrease in PSMbeta1 levels in Staphylococcus aureus USA300 at subinhibitory concentration after 24 hrs by RP-HPLC/ESI-MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID322753 | Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay | 2007 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 35, Issue:3 | Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. |
| AID323007 | Antibacterial activity against drug-resistant Propionibacterium acnes SW101T after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID261796 | Antibacterial activity against Haemophilus influenzae ATCC 9006 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID187381 | Plasma concentration in rats was determined by oral administration, 20 mg/kg at 8 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID542603 | Antimicrobial activity against Staphylococcus epidermidis C960 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID521965 | Antimicrobial activity against erythromycin resistant Campylobacter sp. assessed as clear zone of inhibition by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID544283 | Antimicrobial activity against Enterococcus faecalis NKH13 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1368274 | Antibacterial activity against Staphylococcus aureus RN4220 over-expressing FabI by microbroth dilution method | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | A novel series of enoyl reductase inhibitors targeting the ESKAPE pathogens, Staphylococcus aureus and Acinetobacter baumannii. |
| AID529161 | FIC index, ratio of MIC for Pseudomonas aeruginosa 100609 in presence of 250 ug/ml polyethylenimine to MIC for Pseudomonas aeruginosa 100609 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID530123 | Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus 56 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID554658 | Antimicrobial activity against Ureaplasma parvum isolate UHWP2 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID386623 | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19 | Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. |
| AID554955 | Inhibition of large ribosomal subunit assembly in Escherichia coli assessed as accumulation of 23S rRNA in 40S fraction at 100 ug/ml after 2 hrs by sucrose gradient fractionation at 25 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID574906 | Upregulation of sarA gene expression in Staphylococcus epidermidis SW036 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID1061908 | Apparent permeability from basolateral to apical side in human Caco2 cells at 10 uM after 90 mins by LC-MS/MS analysis | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1 | The synthesis of novel taxoids for oral administration. |
| AID340860 | Antimicrobial activity against vancomycin-intermediate resistant Staphylococcus aureus Mu50 vraG mutant microdilution assay | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. |
| AID528705 | Antibacterial activity against Streptococcus mitis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID326029 | Antimicrobial activity against Campylobacter coli RN14BE8-1 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1217705 | Time dependent inhibition of CYP2B6 (unknown origin) at 100 uM by LC/MS system | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID586041 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 5 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID562378 | Antimicrobial activity against erythromycin-susceptible Streptococcus agalactiae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID529872 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring pAT392 containing mph(B) gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID1428626 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 by broth microdilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. |
| AID571256 | Antimicrobial activity against Campylobacter jejuni DC15 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID562406 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID458152 | Antimicrobial activity against Streptococcus mutans KCTC 3065 assessed as total bacterial adherence inhibition | 2010 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3 | The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens. |
| AID1215348 | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by LC-MS/MS analysis | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jun, Volume: 39, Issue:6 | A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors. |
| AID1211808 | Drug excretion in iv dosed dog assessed as compound excreted into bile | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID325019 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 981 isolate with erm(B) resistance gene from patient blood by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID528703 | Antibacterial activity against Streptococcus oralis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID529879 | Antimicrobial activity against Enterococcus faecalis JH2-2 harboring empty vector by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID548746 | Antimicrobial activity against viridans group Streptococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1055337 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 09-3 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID31896 | Minimum inhibitory concentration against Staphylococcus aureus ATCC 6538PEry-S | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID571473 | Antimicrobial activity against Campylobacter jejuni JL287 harboring 23S rRNA A2074C mutant selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID571453 | Antibacterial activity against Enterobacter cloacae ATCC 23355 ATCC 13883 by Etest method in presence of NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID404900 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB40 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID571254 | Antimicrobial activity against Campylobacter jejuni DC13 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID588208 | Literature-mined public compounds from Lowe et al phospholipidosis modelling dataset | 2010 | Molecular pharmaceutics, Oct-04, Volume: 7, Issue:5 | Predicting phospholipidosis using machine learning. |
| AID571483 | Antimicrobial activity against Campylobacter jejuni JL297 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1225388 | Antibacterial activity against Escherichia coli transformed with plasmid carrying MG1655 deltaBC/pABM by p-iodonitrotetrazolium chloride colorimetric assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp. |
| AID520081 | Antimicrobial activity against aheB deficient kanamycin-resistant Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring plasmid pEX19Gm by agar dilution method in presence of 64 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID554649 | Antimicrobial activity against Ureaplasma urealyticum isolate HPA6 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID278547 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum ATCC 15696 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID535640 | Antimicrobial activity against Group B streptococcus serotype Ib C2 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID161940 | In vitro inhibitory activity against Pneumococci PenR (65) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID554875 | Antimicrobial activity against Streptococcus pneumoniae serotype 18C ST 496 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID574927 | Enhancement of biofilm formation Staphylococcus epidermidis SW099 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID1502713 | Antimycobacterial activity against Mycobacterium avium isolate MAV4 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID278666 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5739 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID127945 | Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 4 hr; No detectable concentration of antibiotic | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID524896 | Antibacterial activity against macrolide resistant and mef-positive Streptococcus pneumoniae by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. |
| AID279885 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 125 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID278678 | Antibacterial activity against Enterococcus faecium isolate 5749 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID1055328 | Antibacterial activity against extended spectrum beta-lactamase producing Escherichia coli 09-1 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID565041 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus hominis assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID278533 | Antimicrobial activity against Bifidobacterium breve R0070 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID127954 | Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 1 hr; No detectable concentration of antibiotic | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID1594378 | Antibacterial activity against AcrAB-TolC deficient Escherichia coli JW25113 after 18 to 24 hrs in presence of colistin by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID574909 | Enhancement of biofilm formation Staphylococcus epidermidis SW027 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID396032 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP3 plasmid containing Enterobacter aerogenes acrR gene by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1424067 | Antibiotic activity against methicillin-resistant Staphylococcus aureus isolate CAIRD142 by broth microdilution assay or Alamar blue dye based colorimetric assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. |
| AID368422 | Antimicrobial activity against Escherichia coli KAM32 pSTVqepA containing qepA gene ligated to pSTV28 plasmid by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID679509 | TP_TRANSPORTER: uptake in OAT2-expressing oocytes | 2005 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 33, Issue:5 | Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. |
| AID325012 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 547 isolate with erm(B) resistance gene from patient sinuitis by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID440238 | Ratio of IC50 for human ERG to EC50 for rabbit motilin receptor agonism | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety. |
| AID168836 | Fluid concentration in urine was determined in rats at 6 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID571476 | Antimicrobial activity against Campylobacter jejuni JL290 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 8 ug/ml after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID547542 | Antimicrobial activity against invasive Streptococcus constellatus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence o | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID678749 | TP_TRANSPORTER: inhibition of Cyclosporin A efflux (CsA: 0.005 uM, Erythromycin: 100 uM) in P388/S and P388/ADR cells | 2000 | Clinical and experimental pharmacology & physiology, Aug, Volume: 27, Issue:8 | Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo. |
| AID554867 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 3245 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID278561 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1502706 | Antimycobacterial activity against Mycobacterium avium 104 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID586078 | Antibacterial activity against quinupristin-dalfopristin abd erythromycin sensitive aEnterococcus faecium U201 transconjugants receiving ermB genes and vatG gene from quinupristin-dalfopristin resistant Enterococcus faecium isolate | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID571443 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 by Etest method in presence of 1 ug/ml NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID1625276 | Antimalarial activity against Plasmodium falciparum FCR 3TC after 48 hrs | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12 | Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. |
| AID424766 | Antibacterial activity against vancomycin, linezolid-resistant Enterococcus faecium CL5791 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID530126 | Antimicrobial activity against community acquired methicillin-resistant Staphylococcus aureus 144 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID261788 | Antibacterial activity against Staphylococcus aureus ATCC 6538p | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID562586 | Antimicrobial activity against Streptococcus agalactiae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID424322 | Antimicrobial activity against Dialister micraerophilus assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID547757 | Antimicrobial activity against invasive Streptococcus intermedius obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID278497 | Antibacterial activity against Pneumococcus DAW67 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID379524 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | 2006 | Journal of natural products, Nov, Volume: 69, Issue:11 | Acetylated flavanone glycosides from the rhizomes of Cyclosorus acuminatus. |
| AID575101 | Antimicrobial activity against Streptococcus pneumoniae serotype 23B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1617371 | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 15 to 90 mins by LC-ESI-MS/MS analysis | 2019 | Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22 | Development of Robust 17( |
| AID40647 | Antibacterial activity against Bacillus subtilis ATCC 6633 | 1987 | Journal of medicinal chemistry, Nov, Volume: 30, Issue:11 | Macrolides with gastrointestinal motor stimulating activity. |
| AID564826 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID573140 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID444050 | Fraction unbound in human plasma | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID261798 | Antibacterial activity against Haemophilus influenzae EH001 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID325029 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 376 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID535637 | Antimicrobial activity against Group B streptococcus serotype Ib R3 harboring Q557E, A400V mutations in PBP 2X and T567I, G539E mutations in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID571472 | Antimicrobial activity against Campylobacter jejuni JL286 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID276732 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents. |
| AID519666 | Inhibition of PAR2-mediated SLIGKV-NH2-induced interleukin-8 production in normal human epidermal keratinocytes at 100 uM preincubated for 24 hrs by ELISA | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. |
| AID512006 | Antibacterial activity against erythromycin-resistant, methicillin-susceptible Staphylococcus aureus A265 by broth microdilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: a novel class of acylides. |
| AID309832 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis NCTC-12203 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID571262 | Antimicrobial activity against Campylobacter jejuni DC21 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID586049 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type U6 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID8442 | Minimum inhibitory concentration against Streptococcus pyogenes 930MLSB | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID1870142 | Antibacterial activity against wild type Staphylococcus aureus 4904/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID424841 | Inhibition of ribosomal activity in erythromycin-sensitive Escherichia coli BL21 assessed as luciferase production by transcriptional and translational assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID202102 | In Vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 (Ery-S strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID206081 | In vitro inhibitory activity against Streptococci EryRi (98) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID565731 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group G clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID155563 | Minimum inhibitory concentration against Streptococcus pyogenes PIU2548 efflux | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID648733 | Antibacterial activity against Staphylococcus aureus ATCC 29213 treated for 24 hrs followed by compound treated at 2 to 16 times MIC measured after 24 hrs by micro dilution method | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds. |
| AID1355942 | Antimicrobial activity against Staphylococcus aureus KB210 ATCC 6538p assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID559761 | Antimycobacterial activity against Mycobacterium smegmatis MC2 155 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID112491 | In Vivo evaluation for its effective dose against Streptococcus pneumoniae (030RO1 EryRi) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID557209 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent susceptible isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID532982 | Antibacterial activity against Escherichia coli W3110 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID571461 | Antimicrobial activity against Campylobacter jejuni DC36 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID519482 | Antibacterial activity against Staphylococcus aureus T2019 with G2576T mutation in 23S rRNA genes by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. |
| AID534337 | Antimicrobial activity against Burkholderia pseudomallei Bp216 harboring mini-Tn7T after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID542608 | Antimicrobial activity against Bacillus subtilis C971 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID547193 | Antibacterial activity against Campylobacter jejuni assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea. |
| AID575147 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID404898 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB33 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID1331168 | Antimicrobial activity against Enterococcus faecium DSMZ 20477 after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID613458 | Antibacterial activity against Staphylococcus aureus NCIM 2122 after 24 hrs by NCCLS method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. |
| AID586044 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type 4 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID674452 | Antibacterial activity against macrolide-susceptible Staphylococcus aureus ATCC 29213 | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and antibacterial activity of desosamine-modified macrolide derivatives. |
| AID210219 | In vitro antibacterial activity against Streptococcus pneumoniae 5649 (efflux-resistant strain bearing a mef (E) gene) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID278877 | Inhibition of metabolic activity in primary human osteoblasts in presence of 10% FCS | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID1327933 | Antibacterial activity against Escherichia coli ATCC 10536 at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID557394 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent resistant isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID1159114 | Antimicrobial activity against Bacillus cereus ATCC 11778 assessed as zone of inhibition at 15 mg for 24 hrs at 30 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID1525340 | Antibacterial activity against Streptococcus pneumoniae UNT-042 expressing ermB/mefA by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID529867 | Antimicrobial activity against Streptococcus uberis UCN61 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID113496 | ED50 value was measured by po administration against streptococcus pneumoniae infection in mice (in vivo, in experiment 3) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID404951 | Antibacterial activity against methicillin-resistant coagulase-negative Staphylococcus sp. assessed as percent resistant isolates by CLSI dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. |
| AID326027 | Antimicrobial activity against Campylobacter coli RN14BE4-3 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID533660 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring plasmid VGA | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. |
| AID544824 | Antimicrobial activity against Staphylococcus aureus Xen 30 biofilm assessed as log10 CFU/cm'2 in bacterial count | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID356436 | Antibacterial activity against Bacillus IP 5832 after 24 hrs by agar dilution method | 2003 | Journal of natural products, Sep, Volume: 66, Issue:9 | Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericumatomarium ssp. degenii. |
| AID562582 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278545 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID542607 | Antimicrobial activity against Enterococcus faecalis C625 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID576347 | Bactericidal activity against Chlamydia trachomatis serovar I infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID85793 | In vitro inhibitory activity against Haemophilus AmpS (43) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID544275 | Antimicrobial activity against Enterococcus faecalis NKH5 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1237454 | Inhibition of bio-film formation of Micrococcus luteus MTCC 2470 incubated for 24 hrs at 37 degC under static conditions by crystal violet staining method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID586068 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB gene expressing Enterococcus faecium isolate CS103 containing streptogramin A resistance genes vatG and vgaD isolated from poultry stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID326043 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 3 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID540219 | Volume of distribution at steady state in monkey after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID1331166 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID322999 | Antibacterial activity against drug-resistant Propionibacterium acnes EG3NS after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID527491 | Octanol-water partition coefficient, log P of the compound by deuterium-free NMR method | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22 | A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents. |
| AID571438 | Antibacterial activity against Escherichia coli IH3080 by Etest method in presence of 2 ug/ml NAB7062 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID581465 | Displacement of [14C]-erythromycin from Escherichia coli K-12 70S ribosome after 10 mins by competitive binding assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID560516 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate 11b091 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1159106 | Antimicrobial activity against Salmonella typhimurium ATCC 14028 assessed as zone of inhibition at 15 mg for 24 hrs at 37 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID396026 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID278926 | Antibacterial activity against Moraxella catarrhalis | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. |
| AID325013 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 552 isolate with erm(B) resistance gene from patient sinuitis by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID404899 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB34 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID278486 | Antibacterial activity against Pneumococcus DAW22 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID516166 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates assessed as susceptible isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID278664 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus isolate 595 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID561729 | Antibacterial activity against Enterococcus faecalis assessed as susceptible isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID554982 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as accumulation of assembly-deffective particles between 50S and 20S regions after 10 mins by sucrose gradient fractionation | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID519331 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT06 carrying duplication in the carboxy-terminal region of L22 ribosomal protein | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID555114 | AUC (0 to infinity) in healthy human at 500 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID1058369 | Antibiofilm activity against Staphylococcus aureus MTCC 96 after 24 hrs by crystal violet assay | 2013 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24 | Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles. |
| AID718414 | Antibacterial activity against log-phase vancomycin-sensitive Enterococcus faecalis ATCC 19433 assessed as growth inhibition after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents. |
| AID261795 | Antibacterial activity against Enterococcus faecalis ATCC 51575 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID278484 | Antibacterial activity against Pneumococcus DAW15 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID529868 | Antimicrobial activity against Escherichia coli AG100A harboring pAT392 containing rdmC-like gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID1055332 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis R6512 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID160384 | In vitro antimicrobial activity against anaerobic bacteria propionibacterium acnes 79 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID721792 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 8325-4 assessed as growth inhibition after 24 hrs by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes. |
| AID411913 | Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. |
| AID279907 | Attenuation of THP1 cell invasion by Burkholderia pseudomallei KHW at 8 ug/ml | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID278483 | Antibacterial activity against Pneumococcus DAW14 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID565078 | Antibacterial activity against community-acquired methicillin-resistant Staphylococcus aureus 156 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model. |
| AID1361121 | Bacteriostatic activity against Klebsiella pneumoniae BAA 1706 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID556351 | Antimicrobial activity against Mycoplasma pneumoniae FH by microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China. |
| AID529870 | Antimicrobial activity against Escherichia coli AG100A harboring pAT392 containing mph(B) and rdmC-like genes by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID562413 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group C clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID208126 | In vitro inhibitory activity against Streptococcus pneumoniae (EryRc 030SJ1) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID1327934 | Antibacterial activity against Sarcina lutea at 5 mg after 24 hrs by agar well diffusion assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities. |
| AID562411 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group G clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID278680 | Antibacterial activity against Enterococcus faecium isolate 5751 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID554864 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 271 harboring ERY-resistant erm(B) and mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID325005 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 897 isolate with erm(B) resistance gene from patient bronchoalveolar lavage by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID574718 | Upregulation of sigB gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID322993 | Antibacterial activity against drug-resistant Propionibacterium acnes D-04/97 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID279905 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 3.9 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID278495 | Antibacterial activity against Pneumococcus DAW65 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID278674 | Antibacterial activity against Enterococcus faecalis isolate 5744 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID535769 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID326072 | Inhibition of pneumococcal surface protein A production in Streptococcus pneumoniae NMU112 lysates at 10 ug/mL after 12 hrs by Western blot relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID535567 | Antibacterial activity against Salmonella enterica serovar blockley harboring G235A mutation in rlpD gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro activity of azithromycin against nontyphoidal Salmonella enterica. |
| AID1544294 | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTS/PMS assay | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11 | Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens. |
| AID537106 | Chlamydiostatic activity against Chlamydia pneumoniae CV6 infected in human Hep2 cells after 72 hrs by fluorescence assay | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. |
| AID1870144 | Antibacterial activity against wild type Staphylococcus aureus 4883/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID208783 | In vitro antibacterial activity against erythromycin efflux resistant Streptococcus pneumoniae 210 strain | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. |
| AID584995 | Antibacterial activity against pSCFS7-deficient methicillin-resistant Staphylococcus aureus M05/0060-C1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. |
| AID1355954 | Antimicrobial activity against Saccharomyces cerevisiae BY4741 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID424836 | Antibacterial activity against erythromycin-resistant Propionibacterium acnes with A2059 mutation in domain V of 23S rRNA | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID326067 | Antimicrobial activity against Streptococcus pneumoniae NMUP45 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID561501 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Characterization of ermA in macrolide-susceptible strains of methicillin-resistant Staphylococcus aureus. |
| AID554972 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as retardation of 16S rRNA processing at 7 ug/ml after 2 hrs by primer extension analysis at 25 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID548256 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID325010 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 443 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID532990 | Antibacterial activity against Klebsiella pneumoniae NCIM 2883 assessed as growth inhibition in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID574709 | Antimicrobial activity against Staphylococcus epidermidis SW036 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID718270 | Antimicrobial activity against Escherichia coli ATCC 25922 | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID562223 | Antimicrobial activity against Desulfovibrio desulfuricans MB by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID565192 | Antimicrobial activity against Acinetobacter baumannii JVAB01 expressing disrupted open reading frame orf3 mutant deficient in efflux pump CraA by Etest | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. |
| AID276854 | Inhibition of concanavalin A-induced IL4 release in human PBMC at 10 uM relative to Dexamethasone | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID544825 | Antimicrobial activity against Staphylococcus aureus Xen 30 biofilm assessed as log10 CFU/cm'2 in bacterial count in presence of 2000 microamperes of electric current by bioelectric effect assay | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID326052 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 7 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID544636 | Antimicrobial activity against Staphylococcus aureus Xen 30 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. |
| AID560508 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b3k5923 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID571481 | Antimicrobial activity against Campylobacter jejuni JL295 selected at 2 ug/ml after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID562221 | Antimicrobial activity against Desulfovibrio fairfieldensis by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Susceptibilities of 23 Desulfovibrio isolates from humans. |
| AID1899688 | Bacteriolytic activity against Enterococcus faecium LMG 16003 incubated for 2 hrs | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action. |
| AID1594144 | Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme acti | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID1355953 | Antimicrobial activity against Saccharomyces cerevisiae KF237 ATCC 9763 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID362542 | Antibacterial activity against macrolide-resistant Staphylococcus aureus RN4220 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID36452 | Alpha-1-glycoprotein binding ability was measured | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | A comparative NMR study between the macrolide antibiotic roxithromycin and erythromycin A with different biological properties. |
| AID1210069 | Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID278505 | Antibacterial activity against Pneumococcus CDC020 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID724506 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID112357 | In Vivo evaluation for its effective dose against Haemophilus influenzae (351TO19 AmpR beta (-)) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID278988 | Antibacterial activity against Pseudomonas sp. B13 GFP1 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. |
| AID573132 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID560514 | Antimicrobial activity against SCCmec type IV vancomycin-intermediate Staphylococcus aureus isolate 06b41 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID1573588 | Efflux ratio of apparent permeability in human Caco2 cells measured at 90 mins time interval by LC-MS/MS analysis | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20 | Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors. |
| AID584328 | Antibacterial activity against gshB deficient Escherichia coli JW2914-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID544279 | Antimicrobial activity against Enterococcus faecalis NKH9 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID571247 | Antimicrobial activity against Campylobacter jejuni DC6 harboring 23S rRNA A2074G mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID565230 | Antimicrobial activity against Mycobacterium chelonae 9917 by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID208752 | Minimum inhibitory activity against Streptococcus agalactiae CMX 508 | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6 | Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A. |
| AID562354 | Antimicrobial activity against erythromycin-, streptomycin-resistant Enterococcus faecium A expressing hylEfm gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID565035 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus sciuri assessed as intermediate resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID571462 | Antimicrobial activity against Campylobacter jejuni DC37 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID161933 | In vitro inhibitory activity against Pneumococci PenR (65) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID679511 | TP_TRANSPORTER: inhibition of theophylline uptake in OAT2-expressing oocytes | 2005 | Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 33, Issue:5 | Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. |
| AID41110 | In vitro antimicrobial activity against anaerobic bacteria bacteroides corrodens 1874 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID512009 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 3469 by broth microdilution method | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: a novel class of acylides. |
| AID523016 | Ratio of Kcat to Km for macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay in presence of GTP | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID573126 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID542604 | Antimicrobial activity against Staphylococcus epidermidis isolate C621 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID571450 | Antibacterial activity against Enterobacter cloacae ATCC 23355 ATCC 13883 by Etest method in presence of 2 ug/ml NAB7062 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID584329 | Antibacterial activity against gspS deficient Escherichia coli JW2956-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID326058 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 10 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID571244 | Antimicrobial activity against Campylobacter jejuni DC3 harboring 23S rRNA A2074G mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1055939 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 after 20 hrs | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID411675 | Antibacterial activity against ampicillin-resistant Haemophilus influenzae 33929 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID278682 | Antibacterial activity against Enterococcus faecium isolate 5753 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID603986 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae B1 expressing erm gene by broth microdilution method | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | Synthesis and antibacterial activity of novel 4″-O-benzimidazolyl clarithromycin derivatives. |
| AID1368273 | Antibacterial activity against Staphylococcus aureus RN4220 by microbroth dilution method | 2018 | Bioorganic & medicinal chemistry, 01-01, Volume: 26, Issue:1 | A novel series of enoyl reductase inhibitors targeting the ESKAPE pathogens, Staphylococcus aureus and Acinetobacter baumannii. |
| AID135350 | Plasma concentration in mice was determined by subcutaneous administration, 20 mg/kg at 4 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID678444 | Antibacterial activity against Salmonella enterica at 12 ug/well after 24 hrs by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction. |
| AID210376 | In vitro antibacterial activity of ATCC 6303 strain of Gram positive bacteria Streptococcus pneumoniae | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 2. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbazate erythromycin A analogues. |
| AID168680 | Fluid concentration in liver tissue was determined in rats at 4 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID519667 | Inhibition of PAR2-mediated SLIGKV-NH2-induced interleukin-8 production in normal human epidermal keratinocytes at 5 uM preincubated for 24 hrs by ELISA | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. |
| AID718269 | Antimicrobial activity against Escherichia coli DH5[alpha] | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID50849 | In vitro antimicrobial activity against anaerobic bacteria Clostridium difficile 2994 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID508374 | Antibacterial activity against Streptococcus pneumoniae harboring mutation in 23S rRNA after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID586050 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type U8 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID681120 | TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in Caco-2 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID548796 | Antimicrobial activity against Oxacillin-resistant coagulase-negative Staphylococcus assessed as percent resistant isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID571241 | Antimicrobial activity against Campylobacter jejuni NCTC 11168 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID562365 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus Group F clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID569030 | Antimicrobial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. |
| AID554553 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC1082 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID356437 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by agar dilution method | 2003 | Journal of natural products, Sep, Volume: 66, Issue:9 | Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericumatomarium ssp. degenii. |
| AID347516 | Potentiation of electric field stimulated-rabbit gastric antrum contraction at 3 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID554859 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 3247 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID1596575 | Antibacterial activity against Escherichia coli JW55031 harboring deltatolC mutant assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID1474200 | Antibacterial activity against Klebsiella pneumoniae BAA-1706 after 18 to 22 hrs in presence of 1/4 times MIC colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID532981 | Antibacterial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID554651 | Antimicrobial activity against Ureaplasma urealyticum isolate HPA17 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID574713 | Upregulation of icaA gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID206124 | In vitro antibacterial activity against A-5278 strain of Staphylococcus aureus | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID424846 | Inhibition of ribosomal activity in erythromycin-sensitive Escherichia coli BL21 S30 extracts assessed as inhibition of luciferase activity by transcriptional and translational assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID411677 | Antibacterial activity against Moraxella catarrhalis by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID1055339 | Antibacterial activity against thiostrepton-resistant Staphylococcus aureus ATCC 6538P assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID540231 | Dose normalised AUC in dog after po administration | 2005 | Xenobiotica; the fate of foreign compounds in biological systems, Feb, Volume: 35, Issue:2 | Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. |
| AID1221975 | Transporter substrate index ratio of permeability from apical to basolateral side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID519833 | Antimicrobial activity against Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring plasmid pEX19Gm by agar dilution method in presence of 64 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID444055 | Fraction absorbed in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID571504 | Antimicrobial activity against Campylobacter jejuni DC26 infected in 15 days old chicken by agar dilution method in presence of food with tylosin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID765066 | Bactericidal activity against methicillin-sensitive Staphylococcus aureus 8325-4 | 2013 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 | Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. |
| AID1194855 | Antimicrobial activity against Escherichia coli MTCC 739 assessed as inhibition of biofilm formation after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, May-01, Volume: 25, Issue:9 | One-pot catalyst free synthesis of novel kojic acid tagged 2-aryl/alkyl substituted-4H-chromenes and evaluation of their antimicrobial and anti-biofilm activities. |
| AID516168 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus clinical isolates assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID288354 | Antibacterial activity against Streptococcus pyogenes after 24 hrs by microdilution method | 2007 | Bioorganic & medicinal chemistry, Jul-01, Volume: 15, Issue:13 | Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides. |
| AID424834 | Antibacterial activity against erythromycin-resistant Propionibacterium acnes with G2057A mutation in domain V of 23S rRNA | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID279890 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 3.9 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID1677804 | Antibacterial activity against Staphylococcus aureus clinical isolate incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID528715 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus auricularis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID529520 | Antibacterial activity against thymidine-dependent small-colony variant Staphylococcus aureus derived from cystic fibrosis patient assessed as resistant isolates at 37 degC after 24 hrs by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. |
| AID325445 | Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID88249 | In vitro inhibitory activity evaluated against Helicobacter pylori (HP) | 1999 | Bioorganic & medicinal chemistry letters, Jan-18, Volume: 9, Issue:2 | In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones. |
| AID542600 | Antimicrobial activity against Staphylococcus aureus 305 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID323009 | Antibacterial activity against drug-resistant Propionibacterium acnes FG7E after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID209616 | In vitro inhibitory activity against Streptococcus pyogenes (02A1UC1) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID535633 | Antimicrobial activity against Group B streptococcus serotype Ia R7 harboring T77I, F395V and S353F in PBP 2X; V80A and G613R in PBP 2B; and L45P, N163K, N723S and Y470F in PBP 1A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID559765 | Antimycobacterial activity against PknGMsm-deficient Mycobacterium smegmatis harboring PknG K181M mutant gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. |
| AID41411 | In vitro antimicrobial activity against anaerobic bacteria bacteroides melaninogenicus 1856, | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID573145 | Antibacterial activity against penicillin-susceptible Streptococcus viridans assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID168693 | Fluid concentration in serum was determined in rats at 0.5 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID534110 | Antibacterial activity against TolC deficient Pasteurella multocida pm1980 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID554650 | Antimicrobial activity against Ureaplasma urealyticum isolate HPA12 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID323036 | Antibacterial activity against Streptococcus pyogenes after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID1241209 | Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID571200 | Antibacterial activity against Escherichia coli ATCC 25992 by Etest method in presence of NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID574926 | Enhancement of biofilm formation Staphylococcus epidermidis SW088 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID276838 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus Smith OC4172 in presence of 50% mouse serum | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID1570734 | Antimicrobial activity against Enterococcus faecium AUS0004 at 15 ug/disk incubated for 20 +/- 4 hrs by agar disk diffusion method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics. |
| AID548737 | Antimicrobial activity against Oxacillin-susceptible Staphylococcus aureus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID554675 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 156 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID520395 | Antibacterial activity against erm(B) and mef(E)-positive Streptococcus pneumoniae isolate Sweden 15A-25 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID567569 | Antimicrobial activity against Staphylococcus aureus RN4220 | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. |
| AID554968 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as accumulation of partially processed 23S rRNA in 30S, 40S and 50S fractions at 7 ug/ml after 2 hrs by primer extension analysis at 25 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID323000 | Antibacterial activity against drug-resistant Propionibacterium acnes SW3CD after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID624628 | Drug-stimulated Pgp ATPase activity ratio determined in MDR1-Sf9 cell membranes with test compound at a concentration of 20uM | 2001 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 299, Issue:2 | Rational use of in vitro P-glycoprotein assays in drug discovery. |
| AID576346 | Bactericidal activity against Chlamydia trachomatis serovar H infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID589160 | Mechanism based inhibition of human cytochrome P450 3A4 measured by triazolam alpha- hydroxylation using human liver microsomes | 2005 | Current drug metabolism, Oct, Volume: 6, Issue:5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
| AID584325 | Antibacterial activity against wild type Escherichia coli BW25113 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID574936 | Antimicrobial activity against Staphylococcus epidermidis lacking compound-induced biofilms | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID201405 | In vitro minimum inhibitory concentration for antibacterial activity against erythromycin susceptible strain Staphylococcus aureus Smith | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13 | Synthesis and antibacterial activity of a novel series of acylides: 3-O-(3-pyridyl)acetylerythromycin A derivatives. |
| AID279874 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 500 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1055341 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 09-13 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID262171 | Inhibition of protein synthesis in Escherichia coli cell-free translational system | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Synthesis and biological investigation of new 4''-malonyl tethered derivatives of erythromycin and clarithromycin. |
| AID1355950 | Antimicrobial activity against Proteus vulgaris KB127 NBRC 3167 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID577690 | Antimicrobial activity against Neisseria gonorrhoeae isolate 254921 NG-MAST sequence type 649 selected after 4 mg/L of erythromycin by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | High-level azithromycin resistance occurs in Neisseria gonorrhoeae as a result of a single point mutation in the 23S rRNA genes. |
| AID23271 | Partition coefficient (logD7.4) | 1990 | Journal of medicinal chemistry, Jul, Volume: 33, Issue:7 | Structure-activity relationships of antineoplastic agents in multidrug resistance. |
| AID155915 | Minimum inhibitory concentration against Pasteurella multocida. | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID562373 | Antimicrobial activity against Streptococcus Group C clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID520743 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus RN4220 harboring erm(B) and cfr gene assessed as modification of A2503 site in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID532988 | Antibacterial activity against Klebsiella aerogenes NCIM 2281 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID706059 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus 8325-4 incubated for 24 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. |
| AID598142 | Antimicrobial activity against Micrococcus luteus ATCC 9341 by CLSI method | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. |
| AID283551 | Antimicrobial activity against Streptococcus pneumoniae PC13 transformants | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID586066 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB gene expressing Enterococcus faecium isolate CS121 containing streptogramin A resistance genes vatG and vgaD isolated from poultry stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID368418 | Antimicrobial activity against multidrug-resistant Escherichia coli C316 pHPA containing mutated GyrA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID545051 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ274 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID571250 | Antimicrobial activity against Campylobacter jejuni DC9 harboring 23S rRNA A2074G mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID86124 | In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae 76 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID535647 | Antimicrobial activity against Group B Streptococcus serotype V 2603 V/R harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID699541 | Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10 | Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. |
| AID362544 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after 18 hrs | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. |
| AID581471 | Binding affinity to Escherichia coli K-12 70S ribosome 23S rRNA assessed as protection against CMCT-induced modification of 23S rRNA domain V at nucleotides U790 by primer extension analysis | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID645238 | Antibacterial activity against compound-resistant Streptococcus pyogenes 47 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID206125 | In vitro antibacterial activity against A5177 strain of Staphylococcus aureus | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID588113 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates assessed as percent resistant isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID348713 | Antibacterial activity against efflux-resistant Streptococcus pneumoniae 7701 expressing mefA by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID547758 | Antimicrobial activity against invasive Streptococcus intermedius obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID325446 | Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID1525321 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID187388 | Plasma concentration in rats was determined by subcutaneous administration, 20 mg/kg at 2 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID465593 | Antibacterial activity against Escherichia coli K-12 W3110 after 20 hrs by liquid microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5 | Structure-activity relationships of bacterial outer-membrane permeabilizers based on polymyxin B heptapeptides. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID571764 | Antimicrobial activity against Escherichia coli K-12 3-AG300 harboring acrB::rpsLneo mutant gene | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. |
| AID534346 | Antimicrobial activity against Burkholderia pseudomallei Bp207 harboring deleted (bpeAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID520397 | Antibacterial activity against erm(B) and mef(E)-positive Streptococcus pneumoniae isolate Spain 6B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID276731 | Antiinflammatory activity in topically dosed CD1 mouse assessed as inhibition of PMA-induced ear edema at 0.5 mg/ear | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents. |
| AID520744 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CM05 assessed as modification of A2058 site in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID540230 | Dose normalised AUC in rat after po administration | 2005 | Xenobiotica; the fate of foreign compounds in biological systems, Feb, Volume: 35, Issue:2 | Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. |
| AID428294 | Antimicrobial activity against Acinetobacter baumannii BM4652 expressing adeIJK genes with pAT807 isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID168695 | Fluid concentration in serum was determined in rats at 2 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID586069 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB gene expressing Enterococcus faecium isolate CS098 containing streptogramin A resistance genes vatG and vgaD isolated from poultry stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID534112 | Ratio of MIC for Pasteurella multocida AL435 to MIC for TolC deficient Pasteurella multocida pm1980 | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID347511 | Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 25 to 30 mins by time dependent inhibition assay | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID1546174 | Antimicrobial activity against Streptococcus agalactiae 55118 assessed as zone of inhibition at 100 ug/ml after 24 hrs by disc diffusion method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID527729 | Agonist activity at motilin receptor | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. |
| AID318656 | Antibacterial activity against Haemophilus influenzae TH13 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID112355 | In Vivo evaluation for its effective dose against Haemophilus influenzae (351RD7 AmpR beta (+)) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID512997 | Antimicrobial activity against compound treated Staphylococcus aureus harboring mgrA C12S mutant gene retro-orbitally infected into mouse assessed as reduction in bacterial CFU in liver at 10 ug/ml relative to control | 2006 | Nature chemical biology, Nov, Volume: 2, Issue:11 | An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. |
| AID150756 | Inhibition of P-gp was determined using rhodamine-assay in human CaCo-2 cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID278671 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5736 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID1596580 | Bactericidal activity against Escherichia coli JW55031 harboring deltatolC mutant assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assa | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID325022 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 1022 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID530750 | Induction of PlytR::lacZ gene expression in Staphylococcus aureus SH1000 at 2.5 ug/ml after 2 hrs by beta-galactosidase reporter gene assay relative to untreated control | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials. |
| AID206037 | Minimum inhibitory activity against Staphylococcus epidermidis 3519 | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6 | Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A. |
| AID573144 | Antibacterial activity against penicillin-susceptible Streptococcus viridans assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID279193 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus isolates from skin or soft tissue infection outpatients | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Treatment and outcomes of infections by methicillin-resistant Staphylococcus aureus at an ambulatory clinic. |
| AID547531 | Antimicrobial activity against Streptococcus intermedius obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID595940 | Cytotoxicity against HFF after 48 hrs by MTS assay | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Chemistry and biology of macrolide antiparasitic agents. |
| AID1221979 | Transporter substrate index ratio of permeability from basolateral to apical side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID554983 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as accumulation of assembly-deffective particles between 50S and 20S regions after 60 mins by sucrose gradient fractionation | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID1232318 | Half life in human | 2015 | Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15 | Volume of Distribution in Drug Design. |
| AID574905 | Upregulation of pyrR gene expression in Staphylococcus epidermidis SW036 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID576338 | Antimicrobial activity against Chlamydia trachomatis serovar H infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID123072 | Minimum inhibitory activity against Micrococcus luteus ATCC 9341 | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6 | Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A. |
| AID547662 | Antibacterial activity against erythromycin-resistant Staphylococcus aureus 5677 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID1217706 | Time dependent inhibition of CYP2C9 (unknown origin) at 100 uM by LC/MS system | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID535634 | Antimicrobial activity against Group B streptococcus serotype VI R6 harboring F395L, V405A, R433H, H438Y, A374V and G648A mutations in PBP 2X and T567I mutation in PBP 2B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID1591543 | Antibacterial activity against Staphylococcus aureus clinical isolate incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID560509 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate b4k6307 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID535632 | Antimicrobial activity against Group B streptococcus R8 harboring T77I, S353F and A514V in PBP 2X; V80A and G613R in PBP 2B; and L45P, N163K, N723S and G527V in PBP 1A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID85978 | In vitro antibacterial activity against Haemophilus influenzae GYR1435 (fully susceptible strain) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID1596582 | Bactericidal activity against Pseudomonas aeruginosa ATCC 15442 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs followed by re-plating on tryptic soy agar plates at 37 degC for 18 hrs by broth microdilution assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID557095 | Binding affinity to first site on human serum albumin by SPR | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. |
| AID1525339 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID424763 | Antibacterial activity against Staphylococcus epidermidis CL8040 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID428291 | Antimicrobial activity against Acinetobacter baumannii BM4652 expressing adeABC adeIJK double mutant isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID589161 | Mechanism based inhibition of human cytochrome P450 3A4 measured by triazolam alpha- hydroxylation using recombinant CYP3A4 | 2005 | Current drug metabolism, Oct, Volume: 6, Issue:5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
| AID207077 | In vitro inhibitory activity against Staphylococcus aureus (EryRi 011GO25i) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID545048 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ210 from patient sputum by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID571459 | Antimicrobial activity against Campylobacter jejuni DC34 harboring protein L4 G74D mutant by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID285832 | Antibacterial activity against susceptible Campylobacter jejuni isolates by agar dilution test | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Comparison of disk diffusion and agar dilution methods for erythromycin and ciprofloxacin susceptibility testing of Campylobacter jejuni subsp. jejuni. |
| AID534340 | Antimicrobial activity against Burkholderia pseudomallei Bp50 harboring deleted (amrRAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1596577 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID532024 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 harboring pTY60H carrying the luxAB gene under the hsp60 promoter determined after 14 days in presence of 2.5 ug/ml ATP-cassette transporter inhibitor reserpine | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID278538 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID554858 | Antimicrobial activity against Streptococcus pneumoniae serotype 14 ST 2306 harboring ERY-resistant erm(B) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID533875 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID369650 | Antibacterial activity against Campylobacter jejuni 001B-40 carrying A2075G mutation in 23S rRNA by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. |
| AID584340 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 15 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID571471 | Antimicrobial activity against Campylobacter jejuni JL285 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID206070 | In vitro inhibitory activity against Streptococci EryR (27) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID542387 | Antimicrobial activity against Staphylococcus aureus RN4220 | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID571495 | Antimicrobial activity against Campylobacter jejuni harboring mutation in cmeB by agar dilution method relative to wild type Campylobacter jejuni | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID576353 | Antimicrobial activity against Chlamydia trachomatis UW-36 serovar J infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID518017 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as percent resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro activity of fidaxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp. |
| AID530124 | Antimicrobial activity against community acquired methicillin-resistant Staphylococcus aureus 147 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID530586 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae isolate 685 with A2603G mutation by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID524557 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 assessed as bactericidal at 4 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID278548 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID279897 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 1000 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID369233 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae isolates by double-disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID586045 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type 1 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID1667633 | Antibacterial activity against Streptococcus pneumoniae ATCC 49617 | 2020 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9 | Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains. |
| AID562393 | Antimicrobial activity against oxacillin-resistant Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID168687 | Fluid concentration in lung tissue was determined in rats at 6 h | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID573386 | Antibacterial activity against beta lactamase-positive Moraxella catarrhalis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID564834 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus hominis assessed as susceptible isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID1594376 | Antibacterial activity against Escherichia coli BW25113 after 18 to 24 hrs in presence of colistin by broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID562521 | Antimicrobial activity against erythromycin-, streptomycin-, vancomycin-, gentamicin-resistant Enterococcus faecium TX1330RF-B1 conjugant expressing hylEfm gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID518972 | Induction of erm(C) expression in Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid assessed as increase in A2058 dimethylation in 23S rRNA at 0.8 ug/ml after 30 mins by primer extension assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID574902 | Downregulation of sigB gene expression in Staphylococcus epidermidis SW029 at 8 ug/ml after 24 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID1241205 | Inhibition of pre-miR-372 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID530127 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID540233 | Dose normalised AUC in human after po administration | 2005 | Xenobiotica; the fate of foreign compounds in biological systems, Feb, Volume: 35, Issue:2 | Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. |
| AID574907 | Upregulation of sigB gene expression in Staphylococcus epidermidis SW036 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID278480 | Antibacterial activity against Pneumococcus DAW9 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID573114 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID440234 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae ATCC 6301 | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety. |
| AID533859 | Antibacterial activity against nonpigmented rapidly growing Mycobacterium smegmatis after 3 days by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. |
| AID519834 | Antimicrobial activity against aheB deficient kanamycin-resistant Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring plasmid pEX19Gm by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID1241215 | Ratio of Kd for 5'-FAM-pre-miR-372 (unknown origin) in presence of 100-fold excess of 15-mer DNA to Kd for 5'-FAM-pre-miR-372 (unknown origin) | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID554551 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MAB30 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID1361124 | Bacteriostatic activity against AcrAB-tolC deficient Escherichia coli JW5503-1 after 20 hrs by broth microdilution method | 2018 | European journal of medicinal chemistry, Jul-15, Volume: 155 | N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. |
| AID1685705 | Antimicrobial activity against Escherichia coli DH5alpha assessed as inhibition of bacterial growth incubated for overnight by CLSI method | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12 | Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. |
| AID208918 | Minimum inhibitory activity against Streptococcus bovis A-5169 | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6 | Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A. |
| AID1055335 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis 09-8 assessed as growth inhibition after 18 hrs by agar dilution method | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. |
| AID544274 | Antimicrobial activity against Enterococcus faecalis NKH4 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID288351 | Antibacterial activity against Staphylococcus aureus-cMLS after 24 hrs by microdilution method | 2007 | Bioorganic & medicinal chemistry, Jul-01, Volume: 15, Issue:13 | Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides. |
| AID168686 | Fluid concentration in lung tissue was determined in rats at 4 h | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID562395 | Antimicrobial activity against Staphylococcus epidermidis clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID323001 | Antibacterial activity against drug-resistant Propionibacterium acnes P95 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID1241214 | Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay in presence of 100-fold excess of 15-mer DNA | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID428140 | Antimicrobial activity against Streptococcus pneumoniae PC13 transformant harboring 136-bp deletion in erm(B) gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID519673 | Effect on PAR2 gene expression in normal human epidermal keratinocytes assessed as effect on cell viability at 100 uM after 72 hrs | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. |
| AID325988 | Antimicrobial activity against Streptococcus sp.11923/96 | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci. |
| AID1551812 | Antibacterial activity against Bacillus anthracis incubated for 18 hrs post 30 mins pre-diffusion by disk diffusion method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID765058 | Ratio of MBC to MIC for methicillin-sensitive Staphylococcus aureus 8325-4 | 2013 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 | Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. |
| AID428290 | Antimicrobial activity against Acinetobacter baumannii BM4454 isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID520745 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CM05 assessed as modification of A2503 site in 23S rRNA | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID1210302 | Drug metabolism in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by media-loss method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Aug, Volume: 40, Issue:8 | Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: identifying rate-limiting steps and role of passive processes. |
| AID288355 | Antibacterial activity against Streptococcus pyogenes-M after 24 hrs by microdilution method | 2007 | Bioorganic & medicinal chemistry, Jul-01, Volume: 15, Issue:13 | Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides. |
| AID347512 | Intrinsic activity at human recombinant motilin receptor expressed in CHO cells relative to motilin | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID707516 | Bactericidal activity against methicillin-sensitive Staphylococcus aureus 8325-4 incubated for 24 hrs in broth followed by colony transfer to tryptic soy agar for further 24 hrs incubation | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. |
| AID508687 | Induction of spa virulent gene expression in Staphylococcus aureus PC203 containing spa::lacZ assessed as color chage at 5 ug/ml at 37 degC in presence of chromogenic beta-galactosidase substrate | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Method for screening compounds that influence virulence gene expression in Staphylococcus aureus. |
| AID424756 | Antibacterial activity against macrolide, imipenem, methicillin-resistant Staphylococcus aureus MB5393 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID682024 | TP_TRANSPORTER: increase in kidney concentration in mdr1a(-/-) mouse | 1998 | Archives of biochemistry and biophysics, Feb-15, Volume: 350, Issue:2 | Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. |
| AID409941 | Antibacterial activity against Enterococcus faecalis ATCC 29212 | 2008 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22 | Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs. |
| AID586054 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type 5 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID424421 | Antibacterial activity against Enterococcus faecalis HIP14333 isolated from patients rectum by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. |
| AID562400 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group F clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID326053 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 8 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID278498 | Antibacterial activity against Pneumococcus DAW68 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID206104 | In vitro antimicrobial activity against aerobic bacteria Streptococcus D 8043 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID323005 | Antibacterial activity against drug-resistant Propionibacterium acnes P429:1 (BC) after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID1356822 | Inhibition of bacterial protein synthesis in cell-free Escherichia coli incubated for 1 hr and measured for every 20 mins by bacterial cell-free transcription-translation assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17 | Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID326020 | Antimicrobial activity against Campylobacter jejuni S3BE4-2 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID530122 | Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus 149 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. |
| AID322997 | Antibacterial activity against drug-resistant Propionibacterium granulosum NCTC-11865 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID428293 | Antimicrobial activity against Acinetobacter baumannii BM4651 expressing deltaadeIJK genes isolated from patient with urinary tract infection by E test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. |
| AID113505 | ED50 value was measured by sc administration against streptococcus pneumoniae infection in mice (in vivo, in experiment 3) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID1230066 | Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2691 assessed as inhibition of bacterial growth | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates. |
| AID1221973 | Efflux ratio of permeability from apical to basolateral side over basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID1261123 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae AB11 expressing ermB and mefA genes by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID571474 | Antimicrobial activity against Campylobacter jejuni JL288 harboring 23S rRNA A2074C mutant selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID1217711 | Metabolic activation in human liver microsomes assessed as [3H]GSH adduct formation rate measured per mg of protein at 100 uM by [3H]GSH trapping assay | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID325447 | Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID278490 | Antibacterial activity against Pneumococcus DAW51 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID375939 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 78-13607A after 24 hrs by broth microdilution method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4 | Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens. |
| AID1230064 | Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2272 assessed as inhibition of bacterial growth | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates. |
| AID1594139 | Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme acti | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID765063 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus 8325-4 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 | Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. |
| AID1778129 | Antimicrobial activity against Pseudomonas aeruginosa assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID168675 | Fluid concentration in liver tissue was determined in rats at 0.5 h | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID509630 | Antimicrobial activity against Staphylococcus aureus RN4220 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID483703 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Synthesis and antibacterial activity of novel 4''-O-arylalkylcarbamoyl and 4''-O-((arylalkylamino)-4-oxo-butyl)carbamoyl clarithromycin derivatives. |
| AID369228 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent resistant isolates by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID528717 | Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID571493 | Antimicrobial activity against Campylobacter jejuni JL307 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID554549 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC879-2 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID586077 | Antibacterial activity against quinupristin-dalfopristin resistant and vanA gene expressing Enterococcus faecium isolate GAV12 containing streptogramin A resistance genes vatG and vgaD isolated from chicken meat samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID648734 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 15187 treated for 24 hrs followed by compound treated at 2 to 16 times MIC measured after 24 hrs by micro dilution method | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds. |
| AID323002 | Antibacterial activity against drug-resistant Propionibacterium acnes P401:5 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID114196 | Effective dose in vivo, in mouse inoculated intraperitoneally with 7.05*10e2 CFU of erythromycin susceptible strain Streptococcus pneumoniae IID553 | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13 | Synthesis and antibacterial activity of a novel series of acylides: 3-O-(3-pyridyl)acetylerythromycin A derivatives. |
| AID564824 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID574915 | Enhancement of biofilm formation Staphylococcus epidermidis SW067 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID1870147 | Antibacterial activity against wild type Staphylococcus aureus 4482/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID540214 | Clearance in rat after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID1215349 | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by refined CYP450 IC50 s | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jun, Volume: 39, Issue:6 | A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors. |
| AID368424 | Ratio of MIC for Escherichia coli KAM32 pSTVqepA mutant to MIC for Escherichia coli KAM32 pSTV28 mutant | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID527726 | Induction of contraction in rabbit smooth muscle at EC90 concentration after three cycles of administration and washout measured after 4th dose | 2010 | Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21 | 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. |
| AID529878 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring empty vector by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID554552 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC1028 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID554963 | Inhibition of large ribosomal subunit assembly in Escherichia coli assessed as accumulation of 23S rRNA in 70S and 50S fractions at 100 ug/ml after 1 hr by sucrose gradient fractionation at 37 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID1555435 | Antibacterial activity against Pseudomonas aeruginosa assessed as diameter of zone of inhibition at 15 ug/disc by disc diffusion method | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper. |
| AID1646207 | Antibacterial activity against Haemophilus influenzae | 2020 | Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12 | Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics. |
| AID571449 | Antibacterial activity against Enterobacter cloacae ATCC 23355 ATCC 13883 by Etest method in presence of 1 ug/ml NAB7061 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID309825 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 70 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID318650 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae KT2524 clinical isolate by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID573156 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID326061 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 12 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID209604 | In vitro antibacterial activity against Streptococcus pyogenes 930 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID318651 | Antibacterial activity against Streptococcus pyogenes ATCC 12344 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID323021 | MBC/MIC ratio of Propionibacterium acnes EG7NS | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID724770 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae B1 expressing erm gene by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID1870154 | Antibacterial activity against wild type Staphylococcus aureus 4679/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID276843 | Antibacterial activity against telithromycin-susceptible Haemophilus influenzae ATCC 49766 | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID724771 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial evaluation of novel 11,4″-disubstituted azithromycin analogs with greatly improved activity against erythromycin-resistant bacteria. |
| AID369664 | Ratio of MIC for Campylobacter jejuni 001B-22 carrying A2075G mutation in 23S rRNA to MIC for Campylobacter jejuni 001B-22 cmeB::kanamycin-resistant mutant | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. |
| AID562379 | Antimicrobial activity against Streptococcus agalactiae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1355946 | Antimicrobial activity against Escherichia coli KB213 NIHJ assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID541176 | Antimicrobial activity against multidrug resistant Streptococcus pneumoniae serotype 19F S43 carring erm(B),mef(E) and tet(M) gene | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | New composite genetic element of the Tn916 family with dual macrolide resistance genes in a Streptococcus pneumoniae isolate belonging to clonal complex 271. |
| AID574917 | Enhancement of biofilm formation Staphylococcus epidermidis SW098 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID1355947 | Antimicrobial activity against Klebsiella pneumoniae KB214 ATCC 10031 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID533877 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID520739 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring cfr gene with mutagenized second codon CAG | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID323635 | Antimicrobial activity against group A streptococci assessed as percent resistant isolates by Etest | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Tetracycline resistance in group a streptococci: emergence on a global scale and influence on multiple-drug resistance. |
| AID483706 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae AB1-1 expressing erm and mef gene by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Synthesis and antibacterial activity of novel 4''-O-arylalkylcarbamoyl and 4''-O-((arylalkylamino)-4-oxo-butyl)carbamoyl clarithromycin derivatives. |
| AID1474199 | Antibacterial activity against Enterobacter cloacae BAA-1154 after 18 to 22 hrs in presence of 1/4 times MIC colistin by broth microdilution method | 2017 | Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6 | Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. |
| AID767505 | Antibacterial activity against Escherichia coli ATCC 25922 by standard dilution assay | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18 | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. |
| AID52544 | In vitro antimicrobial activity against chlamydia trachomatis. | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID548524 | Antimicrobial activity against Oxacillin-resistant Staphylococcus aureus assessed as percent resistant isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID112359 | In Vivo evaluation for its effective dose against Staphylococcus aureus (011UC4). | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID424842 | Inhibition of ribosomal activity in erythromycin-sensitive Propionibacterium acnes EG7NS assessed as luciferase production by transcriptional and translational assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID721754 | Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. |
| AID261793 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID1870155 | Antibacterial activity against wild type Staphylococcus aureus 4502/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14 | LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials. |
| AID569032 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae A22072 expressing the mef gene by broth microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains. |
| AID1516023 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID278496 | Antibacterial activity against Pneumococcus DAW66 isolated from sickle cell disease patient | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. |
| AID326026 | Antimicrobial activity against Campylobacter coli RN14BE4-2/A2074G and cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID571242 | Antimicrobial activity against Campylobacter jejuni DC1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID278552 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID520732 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring plasmid LI50 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID1624987 | Antimicrobial activity against AcrB deficient Escherichia coli | 2019 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 29, Issue:7 | Design, synthesis and evaluation of a series of 5-methoxy-2,3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance. |
| AID581473 | Inhibition of poly(A)-dependent synthesis of poly(Lys) using Escherichia coli K-12 70S ribosome at 20 uM after 1 hr by liquid scintillation counting | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID554556 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC1082 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID494446 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 at 100 ug after 24 hrs by paper disc method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. |
| AID326040 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 1 with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID534164 | Antimicrobial activity against Campylobacter coli by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Comparison of disk diffusion and agar dilution methods for erythromycin, ciprofloxacin, and tetracycline susceptibility testing of Campylobacter coli and for tetracycline susceptibility testing of Campylobacter jejuni subsp. jejuni. |
| AID279902 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 31.3 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID699540 | Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10 | Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. |
| AID1517580 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition incubated for 18 hrs by broth dilution method | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines. |
| AID168834 | Fluid concentration in urine was determined in rats at 2 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID326034 | Antimicrobial activity against Campylobacter coli RN14BE8-3 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1232317 | Volume of distribution in human | 2015 | Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15 | Volume of Distribution in Drug Design. |
| AID279878 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 31.3 uM promazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID483705 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae A22072 expressing mef gene by broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Synthesis and antibacterial activity of novel 4''-O-arylalkylcarbamoyl and 4''-O-((arylalkylamino)-4-oxo-butyl)carbamoyl clarithromycin derivatives. |
| AID575082 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1331167 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID592682 | Apparent permeability from apical to basolateral side of human Caco2 cells after 2 hrs by LC/MS/MS analysis | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | QSAR-based permeability model for drug-like compounds. |
| AID276734 | Antibacterial activity against Enterococcus faecalis ATCC 29212 | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22 | Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents. |
| AID586040 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 1 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID1516019 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID534423 | Antibacterial activity against Mycobacterium bovis BCG-Moreau | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics. |
| AID581466 | Binding affinity to Escherichia coli K-12 70S ribosome 23S rRNA A2062 mutant assessed as protection against DMS-induced modification of 23S rRNA domain V at nucleotides A2058 and A2059 by primer extension analysis | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID347518 | Potentiation of electric field stimulated-rabbit gastric antrum contraction at 0.3 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID8628 | Minimum inhibitory concentration against Staphylococcus aureus A 5177 MLSB-i | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID1237456 | Inhibition of bio-film formation of Bacillus subtilis MTCC 121 incubated for 24 hrs at 37 degC under static conditions by crystal violet staining method | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID1852754 | Antibacterial activity against wild type Escherichia coli ATCC 25922 assessed as bacterial growth inhibition by broth microdilution assay | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9 | Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria. |
| AID325023 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 1041 isolate with erm(B) resistance gene from patient blood by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID528708 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID637554 | Antibacterial activity against Streptococcus pyogenes 19615 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID326073 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae NMU112 infected CBA/J mouse assessed as median survival time at 10 mg/kg, po relative to control | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Roxithromycin favorably modifies the initial phase of resistance against infection with macrolide-resistant Streptococcus pneumoniae in a murine pneumonia model. |
| AID366428 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as inhibition zone diameter at 15 ug/disk after 24 hrs by agar diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive brominated metabolites from the red sea sponge Suberea mollis. |
| AID573129 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID679603 | TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM, Erythromycin: 100 uM) in Caco-2 cells | 1999 | Pharmaceutical research, Mar, Volume: 16, Issue:3 | Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. |
| AID278549 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1217709 | Time dependent inhibition of CYP3A4 (unknown origin) at 100 uM by LC/MS system | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID1555431 | Antibacterial activity against Escherichia coli assessed as diameter of zone of inhibition at 15 ug/disc by disc diffusion method | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper. |
| AID326033 | Antimicrobial activity against Campylobacter coli RN14BE8-3 mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID554969 | Inhibition of ribosomal subunit assembly in Escherichia coli assessed as accumulation of partially processed 23S rRNA in 30S, 40S and 50S fractions at 100 ug/ml after 2 hrs by primer extension analysis at 25 degC | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition. |
| AID560522 | Antimicrobial activity against SCCmec type III vancomycin-intermediate Staphylococcus aureus isolate gz07030 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. |
| AID534342 | Antimicrobial activity against Burkholderia pseudomallei Bp58 harboring deleted bpeR::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID567567 | Antimicrobial activity against Bacillus sp. BS-01 expressing multiple resistance gene cfr and phenolic resistance gene fexA obtained from swine feces | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. |
| AID518015 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as percent resistant isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | In vitro activity of fidaxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp. |
| AID1525341 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID544284 | Antimicrobial activity against Enterococcus faecalis NKH14 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1517574 | Antibacterial activity against Acinetobacter baumannii AYE assessed as growth inhibition | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines. |
| AID706057 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 incubated for 24 hrs by broth microdilution method | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22 | A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. |
| AID1261117 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2015 | European journal of medicinal chemistry, Oct-20, Volume: 103 | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. |
| AID245088 | Minimum inhibitory concentration of the compound against Haemophilus influenzae OC4882 was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID1591539 | Antibacterial activity against Bacillus pumilus CMCC63202 incubated for 24 hrs by CLSI protocol based broth microdilution method | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains. |
| AID424837 | Antibacterial activity against Escherichia coli BL21 | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. |
| AID365667 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 032 after 24 hrs by twofold serial dilution method | 2008 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16 | Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment. |
| AID574553 | Decrease in PSMbeta1 levels in Staphylococcus aureus Sanger 252 at subinhibitory concentrations after 24 hrs by RP-HPLC/ESI- MS | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID174476 | Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 1 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID544273 | Antimicrobial activity against Enterococcus faecalis NKH3 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1594368 | Antibacterial activity against Enterobacter cloacae BAA1134 after 18 to 24 hrs by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID565018 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus sciuri assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID648735 | Antibacterial activity against vancomycin-resistant Enterococcus treated for 24 hrs followed by compound treated at 2 to 16 times MIC measured after 24 hrs by micro dilution method | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds. |
| AID157245 | In vitro antimicrobial activity against anaerobic bacteria peptococcus asaccharolyticus 1302 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID544287 | Antimicrobial activity against Enterococcus faecalis NKH17 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID168697 | Fluid concentration in serum was determined in rats at 6 hr | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID547668 | Antibacterial activity against erythromycin-susceptible Haemophilus influenzae 5096 by broth microdilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. |
| AID323027 | Antibacterial activity against Corynebacterium diphtheriae after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID135361 | Plasma concentration of compound in mice by oral administration,20mg/kg at 20 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID112356 | In Vivo evaluation for its effective dose against Haemophilus influenzae (351GR1) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID205753 | In vitro antimicrobial activity against aerobic bacteria Streptococcus epi 222 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID624622 | Apparent permeability (Papp) from apical to basolateral side determined in MDR1-MDCKII cells | 2001 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 299, Issue:2 | Rational use of in vitro P-glycoprotein assays in drug discovery. |
| AID210222 | In vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 (an erythromycin-susceptible strain) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID576343 | Bactericidal activity against Chlamydia trachomatis serovar E infected in pig LLC-MK2 cells monolayers assessed as reduction in number of microbial inclusions after 48 hrs | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. |
| AID279886 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 62.5 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID1596573 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 assessed as reduction in bacterial cell growth incubated for 18 to 20 hrs by broth microdilution method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity. |
| AID279909 | Attenuation of Burkholderia pseudomallei KHW cytotoxicity in THP1 cells at 8 ug/ml in presence of 250 uM prochlorperazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID452745 | Antibacterial activity against Escherichia coli M15 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1 | Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. |
| AID206298 | In vitro antibacterial activity against Staphylococcus aureus NCTC 10649 (erythromycin-susceptible strain) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID309829 | Antimicrobial activity against Staphylococcus aureus 8325 by serial dilution method | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. |
| AID1355956 | Antimicrobial activity against Saccharomyces cerevisiae harboring 12genedelta0HSR-iERG6 mutant assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID206105 | In vitro antimicrobial activity against aerobic bacteria Streptococcus D 9960 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID206875 | Antibacterial activity against Staphylococcus aureus ATCC 6538P | 1987 | Journal of medicinal chemistry, Nov, Volume: 30, Issue:11 | Macrolides with gastrointestinal motor stimulating activity. |
| AID678446 | Antibacterial activity against Bacillus subtilis at 12 ug/well after 24 hrs by agar well diffusion method | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18 | An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction. |
| AID1237441 | Induction of intracellular ROS accumulation in Staphylococcus aureus MLS16 MTCC 2940 sessile biofilm cells at 0.5 to 2 um incubated for 24 hrs at 35 degC by DCFH-DA dye based fluorescence assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15 | Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities. |
| AID283553 | Antimicrobial activity against Streptococcus pneumoniae PC13 isolate with L4 mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID1516027 | Antibacterial activity against Acinetobacter baumannii AB1902 clinical isolate incubated for 18 to 24 hrs by broth microdilution method | 2019 | Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15 | Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID586053 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type 4 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID424320 | Antimicrobial activity against Dialister micraerophilus by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID440237 | Inhibition of human ERG expressed in HEK cells | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety. |
| AID529160 | Antibacterial activity against Pseudomonas aeruginosa 100609 after 20 hrs by broth microdilution assay in presence of 250 ug/ml polyethylenimine | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. |
| AID1159107 | Antimicrobial activity against Micrococcus luteus ATCC 9341 assessed as zone of inhibition at 15 mg for 24 hrs at 30 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID1153413 | Antimicrobial activity against Micrococcus luteus MTCC 2470 assessed as inhibition of biofilm formation after 24 hrs by crystal violet staining-based assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID520872 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU67 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID555112 | Cmax in healthy human at 500 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID528704 | Antibacterial activity against Streptococcus intermedius clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID127937 | Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 1 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID542598 | Antimicrobial activity against Staphylococcus aureus C622 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Antimicrobial activities of jadomycin B and structurally related analogues. |
| AID681143 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cells | 2002 | Molecular pharmacology, May, Volume: 61, Issue:5 | Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. |
| AID1685706 | Antimicrobial activity against Escherichia coli K-12 assessed as inhibition of bacterial growth incubated for overnight by CLSI method | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12 | Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. |
| AID584335 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 10 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID276841 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4051 containing erm(B) | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID529877 | Antimicrobial activity against Escherichia coli AG100A harboring empty vector by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID209415 | MIC value was measured against streptococcus faecalis X66 | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID562581 | Antimicrobial activity against erythromycin-nonsusceptible Streptococcus pyogenes clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1217704 | Time dependent inhibition of CYP1A2 (unknown origin) at 100 uM by LC/MS system | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID278553 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15708 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1594134 | Inhibition of native soluble pig heart MDH assessed as reduction in MDH enzyme activity using sodium mesoxalate as substrate and NADH by malachite green dye based spectrometric analysis | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID581464 | Antimicrobial activity against Escherichia coli TA531 harboring 23S rRNA U2609C mutant after 15 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID535641 | Antimicrobial activity against Group B streptococcus serotype V C1 harboring E63K mutation in PBP 2A and L41S mutation in PBP 1B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12 | Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. |
| AID423274 | Antibacterial activity against azithromycin-tolerant 0.01 MOI Chlamydia trachomatis L2AZM#31 harboring mutation in bacterial ribosomal protein L4 infected in mouse L2 cells treated 2 hrs after infection measured on day 7 by plaque assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. |
| AID1502709 | Antimycobacterial activity against Mycobacterium avium ATCC 25291 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID260949 | Antibacterial activity against Haemophilus influenzae OC4882 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID278871 | Increase in lactate production in MG63 cells at 400 ug/ml by ELISA relative to control | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID143744 | Inhibition of N-acetylphenylalanine-tRNA peptide bond formation by fragment reaction at 10e-5 M | 1989 | Journal of medicinal chemistry, Sep, Volume: 32, Issue:9 | Synthesis and biological activity of photoactive derivatives of erythromycin. |
| AID411670 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 7701 expressing mef gene by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID1210299 | Apparent intrinsic clearance in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by conventional assay | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Aug, Volume: 40, Issue:8 | Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: identifying rate-limiting steps and role of passive processes. |
| AID128094 | Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 4 hr; No detectable concentration of antibiotic | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID586071 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB and vanA gene expressing Enterococcus faecium isolate C19 containing streptogramin A resistance genes vatG and vgaD isolated from poultry stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID279904 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 7.8 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID575946 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID1221972 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 10 uM of MRP2 inhibitor MK571 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID540215 | Volume of distribution at steady state in rat after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID1472748 | Antibacterial activity against Staphylococcus aureus Newman after 24 hrs by broth dilution method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. |
| AID520736 | Antimicrobial activity against erm(B) and cfr-deficient Staphylococcus aureus RN4220 harboring plasmid LI50 by disk diffusion assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1778126 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as microbial growth inhibition by CLSI-protocol based broth microdilution assay | 2021 | Journal of natural products, 04-23, Volume: 84, Issue:4 | Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations. |
| AID369653 | Antibacterial activity against Campylobacter jejuni 001B-40 cmeB::kanamycin-resistant mutant by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. |
| AID318652 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7 | Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID548739 | Antimicrobial activity against Oxacillin-susceptible coagulase-negative Staphylococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID209626 | In vitro minimum inhibitory concentration against Streptococcus pyogenes PIU 2548 using standard agar dilution method | 2000 | Bioorganic & medicinal chemistry letters, Apr-17, Volume: 10, Issue:8 | Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. |
| AID322992 | Antibacterial activity against drug-resistant Propionibacterium acnes SW26 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID325448 | Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID562372 | Antimicrobial activity against erythromycin-susceptible Streptococcus Group C clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID571434 | Antibacterial activity against Escherichia coli ATCC 25992 by Etest method in presence of 4 ug/ml NAB7064 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID718416 | Antibacterial activity against log-phase methicillin-sensitive Staphylococcus aureus 8325-4 assessed as growth inhibition after 24 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24 | 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents. |
| AID571491 | Antimicrobial activity against Campylobacter jejuni JL305 harboring protein L22 with insertion of amino acid TSH at position 98 selected at 4 to 16 times MIC after 3 to 4 days by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID545042 | Antibacterial activity against hospital-acquired methicillin-resistant Staphylococcus aureus clinical isolate BJ043 from patient abdominal drainage by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. |
| AID564827 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus simulans assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID678721 | Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID619450 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by the broth microdilution method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Novel C-4'' modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation. |
| AID278540 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID278536 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID542385 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ST398 expressing cfr, fexA, erm(A), tet(M) and mecA genes | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. |
| AID208795 | In vitro antibacterial activity against erythromycin- susceptible Streptococcus pneumoniae IID553 strain | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. |
| AID1355952 | Antimicrobial activity against Candida albicans KF1 ATCC 64548 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID564831 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus sciuri assessed as resistant isolates after 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | In vitro activities of panduratin A against clinical Staphylococcus strains. |
| AID406622 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID548255 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSn mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID554876 | Antimicrobial activity against Streptococcus pneumoniae serotype 4 ST 205 by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID574922 | Enhancement of biofilm formation Staphylococcus epidermidis SW036 at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID455986 | Permeability across human Caco-2 cells | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19 | Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. |
| AID150758 | P-gp activity was measured by a direct transport assay, using polarized LLC-PK1 epithelial cells | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID444058 | Volume of distribution at steady state in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID571271 | Antimicrobial activity against Campylobacter jejuni DC30 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. |
| AID554653 | Antimicrobial activity against Ureaplasma urealyticum isolate HPA20 after 48 hrs by modified broth microdilution technique | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. |
| AID562598 | Antimicrobial activity against oxacillin-susceptible Staphylococcus haemolyticus clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1355957 | Antimicrobial activity against Aspergillus niger KF103 ATCC 6275 assessed as zone of inhibition at 1 ug/disc measured after 24 to 48 hrs by paper disc method | 2018 | Journal of natural products, 07-27, Volume: 81, Issue:7 | Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. |
| AID516799 | Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction at EC90 concentration treated three cycles of administration measured after 4th dose | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19 | 9-Dihydroerythromycins as non-antibiotic motilin receptor agonists. |
| AID530579 | Antimicrobial activity against Mycoplasma pneumoniae isolate M129 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. |
| AID299387 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4051 containing erm(B) by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID347510 | Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 0 to 5 mins by time dependent inhibition assay | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. |
| AID562356 | Antimicrobial activity against erythromycin-, streptomycin-resistant Enterococcus faecium TX1330RF-A1 conjugant expressing hylEfm gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium. |
| AID554865 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F ST 2694 harboring ERY-resistant mef(E) gene by agar plate dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. |
| AID1225389 | Antibacterial activity against Escherichia coli transformed with plasmid carrying MG1655 deltaBC/pXYM by p-iodonitrotetrazolium chloride colorimetric assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp. |
| AID278556 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID562602 | Antimicrobial activity against Staphylococcus epidermidis clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID323034 | Antibacterial activity against Streptococcus dysgalactiae subsp. dysgalactiae after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID23733 | Calculated partition coefficient (clogP) | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9 | Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida. |
| AID1153416 | Antimicrobial activity against Klebsiella planticola MTCC 530 assessed as inhibition of biofilm formation after 24 hrs by crystal violet staining-based assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13 | Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives. |
| AID613457 | Antibacterial activity against Escherichia coli NCIM 2574 after 24 hrs by NCCLS method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID678768 | TP_TRANSPORTER: increase in liver concentration in mdr1a(-/-) mouse | 1998 | Archives of biochemistry and biophysics, Feb-15, Volume: 350, Issue:2 | Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. |
| AID528707 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID423268 | Antibacterial activity against azithromycin-resistant 0.01 MOI Chlamydia psittaci 6BC BCRBAZ1 harboring A2059G mutation in bacterial 23S rRNA gene infected in mouse L2 cells treated 2 hrs after infection measured on day 7 by plaque assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. |
| AID520084 | Antimicrobial activity against Escherichia coli TG1 harboring plasmid pEX19Gm by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID581476 | Binding affinity to Escherichia coli K-12 70S ribosome Pi complex assessed as inhibition of AcPhe-puromycin synthesis at 10 uM after 2 mins by liquid scintillation counting | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID1482267 | Antibacterial activity against Escherichia coli MG1655 measured every 15 mins for 12 hrs | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Prediction of Antibiotic Interactions Using Descriptors Derived from Molecular Structure. |
| AID1240324 | Antibacterial activity against wild type Pseudomonas aeruginosa PAO1 by broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17 | Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space. |
| AID1221963 | Transporter substrate index ratio of permeability from apical to basolateral side in human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of P-gp inhibitor LY335979 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID365670 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by twofold serial dilution method | 2008 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16 | Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment. |
| AID278565 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID529871 | Antimicrobial activity against Staphylococcus aureus RN4220 harboring pAT392 containing rdmC-like gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. |
| AID589147 | Mechanism based inhibition of human cytochrome P450 3A4 measured by testosterone 6-beta hydroxylation | 2005 | Current drug metabolism, Oct, Volume: 6, Issue:5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
| AID325026 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae 759 isolate with erm(B) resistance gene from patient ear by disk diffusion test | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Molecular epidemiology of telithromycin-resistant pneumococci in Finland. |
| AID276846 | Antibacterial activity against Staphylococcus aureus | 2006 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23 | Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. |
| AID1594372 | Antibacterial activity against Enterobacter cloacae BAA1134 after 18 to 24 hrs in presence of colistin by broth microdilution assay | 2019 | Bioorganic & medicinal chemistry, 05-01, Volume: 27, Issue:9 | Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus. |
| AID278989 | Antibacterial activity against Pseudomonas sp. B13 GFP1 containing multiresistance plasmid pRSB101 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant. |
| AID326059 | Antimicrobial activity against Campylobacter jejuni 700819 mutant 11 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID348714 | Antibacterial activity against ampicillin-resistant Haemophilus influenzae 33929 expressing beta-lactamase by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. |
| AID424764 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis CL8516 after 20 hrs by twofold serial broth dilution method | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa. |
| AID1555492 | Antimycobacterial activity against Staphylococcus aureus FDA 209P by agar diffusion method | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Salinomycin and its derivatives - A new class of multiple-targeted "magic bullets". |
| AID520704 | Antibacterial activity against tetracycline resistant Streptococcus pneumoniae clinical isolate expressing erm(B) and tet(M) gene by agar dilution CLSI method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003. |
| AID574912 | Enhancement of biofilm formation Staphylococcus epidermidis SW045 expressing icaA gene at 1/4 X MIC by microtiter plate assay | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID40211 | Antibacterial activity against Bacillus cereus IFO 3001 | 1987 | Journal of medicinal chemistry, Nov, Volume: 30, Issue:11 | Macrolides with gastrointestinal motor stimulating activity. |
| AID279893 | Attenuation of A549 cell invasion by Burkholderia pseudomallei KHW at 8 ug/ml in presence of 500 uM chlorpromazine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID428239 | Increase in dimethylation at position A2058 of 23S rRNA of Streptococcus pneumoniae PC13 transformant harboring 136-bp deletion in erm(B) gene at 0.25 ug/ml by phosphorimager scanning relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID209904 | Minimum inhibitory activity against Streptococcus pyogenes EES61 | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6 | Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A. |
| AID323015 | Antibacterial activity against drug-resistant Propionibacterium acnes P322:2 after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID278670 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5735 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID366429 | Antibacterial activity against Klebsiella pneumoniae ATCC 10032 assessed as inhibition zone diameter at 15 ug/disk after 24 hrs by agar diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive brominated metabolites from the red sea sponge Suberea mollis. |
| AID575100 | Antimicrobial activity against Streptococcus pneumoniae serotype 22F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID494443 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by twofold serial dilution method | 2010 | European journal of medicinal chemistry, Aug, Volume: 45, Issue:8 | Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. |
| AID150751 | Inhibition of P-glycoprotein using ATPase in MDR1 membranes | 2003 | Journal of medicinal chemistry, Apr-24, Volume: 46, Issue:9 | Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. |
| AID1211851 | Unbound biliary clearance in iv dosed human after 20 hrs | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID174473 | Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 0.5 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID520734 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CM05 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. |
| AID245598 | Minimum inhibitory concentration of the compound against erythromycin-susceptible Staphylococcus aureus Smith OC4172 in 50% mouse serum was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID1331163 | Antimicrobial activity against Klebsiella pneumoniae ATCC 13883 after 16 to 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1 | Bioactivity of topologically confined gramicidin A dimers. |
| AID206123 | In vitro antibacterial activity against 6538P strain of Staphylococcus aureus | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID278541 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID575149 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus VRS3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. |
| AID520394 | Antibacterial activity against mef(E)-positive Streptococcus pneumoniae isolate Spain 9V-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID584341 | Antibacterial activity against kanamycin-resistant acrAB, acrEF deficient Escherichia coli W4680AE absence of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1215347 | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by LC-MS/MS analysis in | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jun, Volume: 39, Issue:6 | A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors. |
| AID71053 | Compound was tested for photoinhibition of Escherichia coli (CIP 548T); Partially resistant | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 | Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria. |
| AID1424066 | Antibiotic activity against methicillin-resistant Staphylococcus aureus isolate CAIRD116 by broth microdilution assay or Alamar blue dye based colorimetric assay | 2017 | Journal of natural products, 04-28, Volume: 80, Issue:4 | The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. |
| AID516160 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolates assessed as susceptible isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. |
| AID574904 | Upregulation of fruA gene expression in Staphylococcus epidermidis SW036 at 8 ug/ml after 6 hrs by RT-PCR relative to untreated control | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. |
| AID244851 | Minimum inhibitory concentration against Streptococcus pneumoniae 5979 strain | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10 | Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. |
| AID1221969 | Apparent permeability from basolateral to apical side of human Caco2 cells at 10 uM up to 120 mins by HPLC-MC analysis in presence of 1 uM of BCRP inhibitor Ko143 | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 39, Issue:2 | Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. |
| AID209883 | Cell free inhibiting activity against erythromycin-susceptible strain Streptococcus pneumoniae 1813 (methylated ribosomes for transcription/translation assay) | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID1677803 | Antibacterial activity against Escherichia coli ATCC25922 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID561747 | Antibacterial activity against Methicillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. |
| AID1211831 | Total biliary clearance in iv dosed human after 20 hrs by duodenal aspiration method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2 | Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID572058 | Ratio of MIC for Escherichia coli KAM32 harboring plasmid pUC18 to MIC for Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. |
| AID574546 | Antimicrobial activity against community-associated methicillin-resistant Staphylococcus aureus Sanger 252 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. |
| AID19635 | Partition coefficient (logP) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3 | A comparative NMR study between the macrolide antibiotic roxithromycin and erythromycin A with different biological properties. |
| AID411669 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae 49619 by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID1217710 | Covalent binding in human liver microsomes measured per mg of protein using radiolabelled compound at 10 uM after 1 hr incubation by liquid scintillation counting | 2011 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 39, Issue:7 | Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. |
| AID323012 | Antibacterial activity against drug-resistant Propionibacterium acnes SW101CDA after 48 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. |
| AID210206 | In vitro antibacterial activity against 5649 strain of Streptococcus pneumoniae | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Anhydrolide macrolides. 1. Synthesis and antibacterial activity of 2,3-anhydro-6-O-methyl 11,12-carbamate erythromycin A analogues. |
| AID187392 | Plasma concentration in rats was determined by subcutaneous administration, 20 mg/kg at 40 min | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11 | Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine. |
| AID586074 | Antibacterial activity against quinupristin-dalfopristin resistant and ermB gene expressing Enterococcus faecium isolate KS46 containing streptogramin A resistance genes vatG and vgaD isolated from healthy human stool samples | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID424331 | Antimicrobial activity against Dialister propionicifaciens assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID1677806 | Antibacterial activity against Bacillus pumilus CMCC63202 incubated for 24 hrs by CLSI-based broth microdilution method | 2020 | Bioorganic & medicinal chemistry, 11-01, Volume: 28, Issue:21 | Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus. |
| AID560247 | Antibacterial activity against Staphylococcus aureus RN4220 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID1570728 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 at 15 ug/disk incubated for 20 +/- 4 hrs by agar disk diffusion method | 2019 | Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21 | Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics. |
| AID85787 | In vitro inhibitory activity against Haemophilus AmpS (43) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID206742 | In vitro antibacterial activity against Staphylococcus aureus A5177 strain | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID279888 | Antimicrobial activity against Burkholderia pseudomallei KHW in presence of 15.6 uM omeprazole | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID428242 | Increase in lag phase of growth for wild type Streptococcus pneumoniae PC13 assessed as doubling time at 1 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID519672 | Effect on PAR2 gene expression in normal human epidermal keratinocytes assessed as effect on cell viability at 10 uM after 72 hrs | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes. |
| AID547519 | Antimicrobial activity against Streptococcus anginosus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID555116 | Half life in healthy human at 500 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID260945 | Antibacterial activity against Staphylococcus aureus OC4172 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID203423 | In vitro inhibitory activity against Staphylococci EryRc (23) | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21 | Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. |
| AID388085 | Antifungal activity at Fusarium oxysporum | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. |
| AID1159116 | Antimicrobial activity against Bacillus thuringiensis assessed as zone of inhibition at 15 mg for 24 hrs at 30 degC by disk diffusion test | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells. |
| AID261781 | Antibacterial activity against Streptococcus pneumoniae ATCC 6301 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID540217 | Volume of distribution at steady state in dog after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7 | Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID174484 | Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 4 hr | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID263388 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 6301 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID1685735 | Growth inhibition of Escherichia coli DH5alpha at 50 uM measured every 15 mins for 12 hrs | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12 | Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. |
| AID520871 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU57 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID278539 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID717271 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by CLSI protocol based broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23 | Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives. |
| AID278521 | Antimicrobial activity against Bifidobacterium animalis ATCC 27536 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID279863 | Antimicrobial activity against Burkholderia pseudomallei KHW | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. |
| AID325449 | Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID532985 | Antibacterial activity against Escherichia coli MG1655 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID571433 | Antibacterial activity against Escherichia coli ATCC 25992 by Etest method in presence of 2 ug/ml NAB7062 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. |
| AID72263 | In vitro antimicrobial activity against anaerobic bacteria fusobacterium symbiosum 1470 | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics. |
| AID554554 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MAB30 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID1127990 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microdilution method | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6 | First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. |
| AID326022 | Antimicrobial activity against Campylobacter jejuni S3BE4-3 mutant with cmeB mutation by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1802450 | Oatp1d1 Transport Assay from Article 10.1074/jbc.M113.518506: \\Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide.\\ | 2013 | The Journal of biological chemistry, Nov-22, Volume: 288, Issue:47 | Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide. |
| AID1346284 | Human motilin receptor (Motilin receptor) | 2005 | The Journal of pharmacology and experimental therapeutics, Jun, Volume: 313, Issue:3 | Desensitization of the human motilin receptor by motilides. |
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| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5996 (44.01) | 18.7374 |
| 1990's | 2883 (21.16) | 18.2507 |
| 2000's | 2590 (19.01) | 29.6817 |
| 2010's | 1683 (12.35) | 24.3611 |
| 2020's | 471 (3.46) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (116.17) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,138 (7.84%) | 5.53% |
| Reviews | 884 (6.09%) | 6.00% |
| Case Studies | 1,300 (8.95%) | 4.05% |
| Observational | 12 (0.08%) | 0.25% |
| Other | 11,190 (77.04%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methylnaltrexone vs Erythromycin for Facilitating Gastric Emptying Time in Critically Ill Patients Intolerant to Enteral Feeding [NCT01117376] | Phase 2 | 42 participants (Anticipated) | Interventional | 2010-05-31 | Terminated(stopped due to The study was prematurely terminated because of unavailibility of Methylnaltrexone in the region) | ||
| A Phase 1, Open-Label, Randomized, Cross-Over Study to Evaluate the Effects of Multiple Doses of Erythromycin on the Pharmacokinetics of a Single Dose of Pregabalin Controlled Release in Healthy Subjects [NCT01342198] | Phase 1 | 18 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Investigating Anti-inflammatory Effects of Topical Antibiotics in an LPS Skin Challenge Model [NCT03779360] | 32 participants (Actual) | Interventional | 2018-10-12 | Completed | |||
| To Determine the Role of Prokinetics in Feed Intolerance in Critically Ill Cirrhosis- A Randomized Placebo Controlled Study [NCT02528760] | 83 participants (Actual) | Interventional | 2015-09-24 | Completed | |||
| Erythromycin Versus Neomycin Treatment for Overt Hepatic Encephalopathy: a Double-blind, Randomised, Controlled Trial. [NCT01097811] | 20 participants (Actual) | Interventional | 2008-06-30 | Active, not recruiting | |||
| A Randomized, Placebo-controlled, Evaluator-blinded, Study to Assess the Anti-inflammatory Effects of Topical Erythromycin and Clindamycin in Patients With Inflammatory Facial Acne [NCT03883269] | Phase 4 | 30 participants (Anticipated) | Interventional | 2018-03-20 | Recruiting | ||
| Selections of Subjects With Dramatic Changes in Their Cardiac Repolarization Parameters After a Pharmacologic Stimulus Aiming to Collect Their Skin Biopsy and Blood Cells [NCT01338441] | Phase 1 | 130 participants (Anticipated) | Interventional | 2011-03-31 | Completed | ||
| Treatment of Dowling Maera Type of Epidermolysis Bullosa Simplex by Oral Erythromycin [NCT01340235] | Phase 3 | 8 participants (Anticipated) | Interventional | 2011-06-30 | Recruiting | ||
| A Drug-drug Interaction Study of Ibrutinib With Moderate and Strong CYP3A Inhibitors in Patients With B-cell Malignancy [NCT02381080] | Phase 1 | 26 participants (Actual) | Interventional | 2015-05-19 | Completed | ||
| Population Pharmacokinetics of Anti-infective Drugs in Children in Anti-infectious Therapies [NCT03113344] | 800 participants (Anticipated) | Observational [Patient Registry] | 2017-06-21 | Recruiting | |||
| Assessing the Effectiveness of Integrative Treatment That Combines Interior and Exterior Treatment Plans in Pediatric Pneumonia: a Program by the Special Scientific Research Fund of Public Welfare Profession of China [NCT02362906] | 1,500 participants (Anticipated) | Interventional | 2014-04-30 | Recruiting | |||
| Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-protocol is Identical to Study No. 0519-10-TLV- Minors' Adjusted Version [NCT02354560] | Phase 4 | 15 participants (Anticipated) | Interventional | 2015-06-30 | Not yet recruiting | ||
| Pilot Study for Use of Prokinetics in Early Enteral Feeding of Preterm Infants ; Double Blind; Cross Over Study Comparing Eryththromycin, Metoclopramide and Placebo [NCT01569633] | 0 participants (Actual) | Interventional | 2011-10-31 | Withdrawn(stopped due to very poor enrollment) | |||
| An Open-label, Parallel Group, Multiple-dose Investigation of the Pharmacokinetics of Tipranavir Soft Elastic Capsules SEDDS and Ritonavir Soft Gel Capsules and Their Effects on Cytochrome P-450 (3A4) Activity in Normal Healthy Volunteers [NCT02251132] | Phase 1 | 113 participants (Actual) | Interventional | 2000-10-31 | Completed | ||
| Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240] | Early Phase 1 | 11 participants (Actual) | Interventional | 2014-03-06 | Terminated(stopped due to Not enough patient enrollment and lack of staffing) | ||
| Erythromycin as a Novel Therapy Against Familial Adenomatous Polyposis and Sporadic Colorectal Cancer by APC Nonsense Mutation Readthrough. [NCT02175914] | Phase 4 | 20 participants (Anticipated) | Interventional | 2014-06-30 | Recruiting | ||
| A Prospective, Multicenter Study on the Long-term Prognosis of Children With Bronchiectasis Treated With Low-dose Erythromycin [NCT03966066] | 70 participants (Anticipated) | Interventional | 2019-08-31 | Not yet recruiting | |||
| An Open-Label Study to Estimate the Effect of Multiple Doses of Erythromycin on the Pharmacokinetics, Pharmacodynamics and Safety of a Single Dose of Rivaroxaban in Subjects With Renal Impairment and Normal Renal Function [NCT01309438] | Phase 1 | 29 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| A Phase 1, Single-center, Open-label, 2-part, 2-treatment Period, 1-sequence, Cross-over, Drug-drug Interaction Study to Investigate the Effect of Erythromycin on SAR443820 (Part A) and the Effect of Itraconazole on SAR443820 (Part B) in Healthy Adult Par [NCT05797753] | Phase 1 | 16 participants (Actual) | Interventional | 2022-02-18 | Completed | ||
| Randomized Controlled Trial of Antibiotic Prophylaxis in Rectal Cancer Surgery: Oral With Intravenous Versus Intravenous Antibiotics. [NCT03436719] | 280 participants (Anticipated) | Interventional | 2017-11-06 | Recruiting | |||
| Risk of QT-prolongation and Torsade de Pointes in Patients Treated With Acute Medication in a University Hospital [NCT02068170] | 178 participants (Actual) | Observational | 2014-02-28 | Completed | |||
| The Value of Amniopatch in Pregnancies Associated With Spontaneous Preterm Premature Rupture of Fetal Membranes:A Randomized Controlled Trial [NCT03473210] | 100 participants (Actual) | Interventional | 2016-10-01 | Completed | |||
| A Phase 1, 3-Part, Open-label, Drug-Drug Interaction Study to Evaluate the Effect of a Moderate CYP3A4 Inhibitor, and of Strong and Moderate CYP3A4 Inducers on the Pharmacokinetics of TAK-279 in Healthy Subjects [NCT05995249] | Phase 1 | 48 participants (Anticipated) | Interventional | 2023-08-11 | Recruiting | ||
| An Open-label, Fixed-sequence Study in Healthy Study Participants to Evaluate the Effect of Coadministered Erythromycin on the Pharmacokinetics and Safety of Padsevonil [NCT03480243] | Phase 1 | 28 participants (Actual) | Interventional | 2018-03-27 | Completed | ||
| The Role of Topical Antibiotic Prophylaxis in Eyelid Surgery [NCT03199911] | Phase 4 | 401 participants (Actual) | Interventional | 2017-10-02 | Completed | ||
| TREAT: Treatment of ppROM With Erythromycin vs. Azithromycin Trial [NCT03060473] | Phase 3 | 324 participants (Anticipated) | Interventional | 2017-02-23 | Recruiting | ||
| ANTERO-4: A Clinical Investigation of the Effects of Erythromycin on Gastric Motility, Assessed With the VIPUN Gastric Monitoring System in Healthy Adults [NCT04066231] | 5 participants (Actual) | Interventional | 2019-09-07 | Terminated(stopped due to Investigational medical device no longer available) | |||
| Immunomodulatory Role and Clinical Impact of Erythromycin in Critically Septic Patients: a Randomized Clinical Trial [NCT04665089] | 110 participants (Actual) | Interventional | 2022-01-01 | Completed | |||
| The Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined With Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion: a Multicenter, Prospective, Randomized, Controlled Clinical Trial [NCT05291403] | 141 participants (Anticipated) | Interventional | 2022-04-06 | Recruiting | |||
| A Phase I, 2-panel, Open-label, Randomized, Crossover Trial in Healthy Subjects to Investigate the Pharmacokinetic Interaction Between TMC435 and CYP3A Inhibitors, Erythromycin and Darunavir/Ritonavir (DRV/r) [NCT01323257] | Phase 1 | 49 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| Population Pharmacokinetics of Cephalosporins and Macrolides in Children With Community Acquired Pneumonia [NCT02775968] | 750 participants (Anticipated) | Observational | 2017-06-21 | Recruiting | |||
| Relationship Between Gastric Emptying and Glycemic Variability in Type 1 Diabetes Mellitus [NCT02755064] | Phase 1 | 30 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| An Open, Prospective, Randomized, Multi-Center Study of the Efficacy and Safety of Intravenous Followed by Oral Azithromycin vs. Cefuroxime Monotherapy or Plus Oral Erythromycin for the Treatment of Chinese Hospitalized Patients With Community- Acquired P [NCT00648726] | Phase 3 | 139 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Impact of Prokinetic Use After Emergency Intestinal Anastomosis on Short and long_term Clinical Outcome [NCT05290753] | 15 participants (Anticipated) | Interventional | 2022-01-01 | Active, not recruiting | |||
| The Role of Induced Phase 3 Contractions in the Control of Hunger and Food Intake [NCT02633579] | 28 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Randomized Phase III Trial of Cefazolin or Combination of Cefazolin and Erythromycin or Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of the Membranes [NCT01401179] | Phase 3 | 101 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| Effect of Intravenous Bolus Infusion of Erythromycin Prior to Endoscopy in Patients Presenting With Variceal Bleeding: A Prospective, Randomized, Double- Blind ,Placebo Controlled, Trial [NCT01060267] | 102 participants (Actual) | Interventional | 2007-01-31 | Completed | |||
| Transplacental Transfer of Drugs Used in Pregnant Women [NCT02622802] | 250 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| [NCT00999232] | Phase 4 | 0 participants | Interventional | 2004-10-31 | Completed | ||
| A Randomized, Open Label Study to Compare the Use of the Dermatological Creams Verutex, Eritex and Fisiogel in the Management of Skin Rash Associated With Tarceva Treatment in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer. [NCT00718315] | Phase 3 | 201 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| [NCT00000120] | Phase 3 | 0 participants | Interventional | 1985-01-31 | Completed | ||
| Phase II Study of Tailored-Dose Docetaxel in Metastatic Breast Cancer [NCT00148070] | Phase 2 | 45 participants (Actual) | Interventional | 1999-03-31 | Completed | ||
| The Effect of Intravenous Erythromycin on Gastric Emptying in Patients Undergoing Rapid Sequence Intubation for Full Stomach - A Randomised, Placebo-controlled, Double-blind Study [NCT00827216] | Phase 2 | 132 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome [NCT00467831] | Phase 1/Phase 2 | 3 participants (Actual) | Interventional | 2007-04-30 | Terminated(stopped due to insufficient enrollment) | ||
| Erythromycin Versus Amoxicillin for Treatment of Antenatal Chlamydia Trachomatis Infection: A Randomized Controlled Trial [NCT01946256] | Phase 2 | 220 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| [NCT02212821] | Phase 4 | 14 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Comparison of Two Macrolides, Azithromycin and Erythromycin, for Symptomatic Treatment of Gastroparesis [NCT01323582] | Phase 2 | 26 participants (Actual) | Interventional | 2009-02-28 | Terminated(stopped due to Original investigator left this institution, replacement investigator retired.) | ||
| Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair [NCT00671203] | Phase 3 | 500 participants (Anticipated) | Interventional | 2007-06-30 | Completed | ||
| Comparison of the Effect of Metoclopramide Versus Erythromycin on Gastric Residual Volume [NCT04682691] | Early Phase 1 | 45 participants (Actual) | Interventional | 2021-01-01 | Enrolling by invitation | ||
| A Comparative Study in the Clinical and Microbial Efficacy of Topical Besifloxocin Ophthalmic Suspension 0.6% With Erythromycin Ophthalmic Ointment 0.5% BID for the Management of Acute Blepharitis [NCT01478256] | Phase 4 | 30 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Phase II Study of Tailored-Dose Docetaxel + Trastuzumab in Her-2 Positive Metastatic Breast Cancer [NCT00146042] | Phase 2 | 22 participants (Actual) | Interventional | 1999-03-31 | Completed | ||
| Red Low Level LASER Versus Narrow Band Ultraviolet B in the Treatment of Facial Acne Vulgaris [NCT04254601] | 45 participants (Actual) | Interventional | 2018-04-01 | Completed | |||
| Preterm Premature Rupture of Membranes: Erythromycin Versus Azithromycin a Randomized Trial Comparing Their Efficacy to Prolong Latency (PEACE Trial) [NCT01556334] | Phase 3 | 0 participants (Actual) | Interventional | 2010-04-30 | Withdrawn(stopped due to Terminated before starting due to need for IND determined by FDA.) | ||
| Phase III Trial of Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission [NCT00021671] | Phase 3 | 3,720 participants | Interventional | Completed | |||
| Randomised Double Blind Placebo Controlled Trial of Effects of Long Term Low Dose Oral Erythromycin Therapy in Patients With Chronic Obstructive Pulmonary Disease [NCT00147667] | Phase 2/Phase 3 | 120 participants | Interventional | 2004-04-30 | Active, not recruiting | ||
| Effects of Erythromycin on Binge Eating and GI Function in Bulimia Nervosa [NCT00304187] | Phase 2 | 29 participants (Actual) | Interventional | 2004-09-30 | Completed | ||
| In Urgency Hight Digestive Haemorrhage : Gastric Preparation for Endoscopy [NCT00259220] | Phase 3 | 270 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| The Effect of Concomitant Administration of Erythromycin and Diltiazem on CYP3A Activity in Healthy Volunteers [NCT00318201] | Phase 4 | 7 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| Effect of Erythromycin Before Endoscopy of Patients With Subtotal Gastrectomy (STG), High Risk of Gastric Stasis : Randomized and Prospective Study [NCT01659619] | Phase 2 | 114 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Comparison of Two Preemptive Treatment Strategies of Panitumumab Mediated Skin Toxicity and Assessment of Quality of Life in Patients With Ras-wildtype Colorectal Cancer [NCT01668498] | Phase 2 | 88 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Magnetic Resonance (MR) Evaluation of the Effect of Erythromycin Upon Gastric and Small Bowel Motility [NCT01379183] | Phase 2/Phase 3 | 40 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Erythromycin Versus Gastric Lavage to Improve Quality of Endoscopic Examination in Patients With Upper Gastrointestinal Bleeding. A Prospective Randomized Trial. [NCT01716572] | Phase 3 | 122 participants (Anticipated) | Interventional | 2012-02-29 | Active, not recruiting | ||
| Study of Erythromycin in GER-Associated Apnea of the Newborn [NCT01825473] | 40 participants (Anticipated) | Interventional | 2012-09-30 | Recruiting | |||
| COVGIC20482: A Multicenter, Consecutive, Randomized Study to Optimize the Bowel Preparation Regimen for the PillCam COLON 2 Capsule Endoscopy Procedure [NCT02481219] | 122 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans [NCT00367419] | Phase 4 | 0 participants | Interventional | Completed | |||
| Comparative Effectiveness and Safety of Inhaled Corticosteroids and Antimicrobial Compounds for Non-CF Bronchiectasis [NCT02714283] | 90,089 participants (Actual) | Observational | 2016-10-28 | Completed | |||
| An Open-Label Study in HIV+ Patients to Determine the Effects of Nevirapine (Viramune) on the Pharmacokinetics of Clarithromycin and Activity of Cytochrome 3A4. [NCT00002194] | Phase 1 | 36 participants | Interventional | Completed | |||
| A Phase 2/3, Randomized, Open-Label, Multi-center Study to Determine the Safety and Efficacy of Solithromycin in Adolescents and Children With Suspected or Confirmed Community-Acquired Bacterial Pneumonia [NCT02605122] | Phase 2/Phase 3 | 97 participants (Actual) | Interventional | 2016-04-30 | Terminated(stopped due to Development not proceeding) | ||
| A Phase 1, Randomised, Open Label, Two Sequence, Two Treatment, Two Way Crossover Study to Estimate the Steady-state Effect of Erythromycin on the Single Dose Pharmacokinetics of Ph-797804 in Healthy Subjects [NCT01589614] | Phase 1 | 12 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| A Two-Part, Open-Label, Fixed-Sequence, Two-Period Crossover Study to Assess the Effects of Erythromycin on the Pharmacokinetics of Relugolix, Estradiol, and Norethindrone After Administration of the Relugolix/Estradiol/Norethindrone Acetate Fixed-Dose Co [NCT04714554] | Phase 1 | 43 participants (Actual) | Interventional | 2021-01-06 | Completed | ||
| Randomized Control Trial Comparing Prokinetics and Their Influence on Endoscopy Outcomes for Upper GI Bleed. [NCT02017379] | 4 participants (Actual) | Interventional | 2014-06-30 | Terminated(stopped due to Could not recruit any subjects) | |||
| [NCT00373919] | 0 participants | Interventional | Not yet recruiting | ||||
| [NCT00368342] | Phase 4 | 0 participants | Interventional | Completed | |||
| Antibiotic Profile of Pathogenic Bacteria Isolated From Postsurgical Site Infections in Public Hospitals in Northern Jordan [NCT05106803] | 24 participants (Actual) | Observational | 2019-08-01 | Completed | |||
| Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam [NCT00589329] | 20 participants (Actual) | Interventional | 2007-12-31 | Terminated(stopped due to published data suggest potential harm in other investigations.) | |||
| Comparative Study Between Different Methods of Enteral Feeding in Acute Severe Pancreatitis [NCT04406506] | 60 participants (Actual) | Observational [Patient Registry] | 2018-06-10 | Completed | |||
| Influence of Erythromycin on ad Libitum Food Intake and the Evaluation of Motilin in Food Timing in Healthy Volunteers and Patients [NCT03024879] | Phase 4 | 15 participants (Anticipated) | Interventional | 2014-03-31 | Enrolling by invitation | ||
| A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population [NCT01592708] | 233 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| Establishment a Nucleic Acid Rapid Detection Technology Platform for Detecting Pathogenic Bordetella and Its Drug Resistance Genes [NCT04535505] | 0 participants (Actual) | Observational | 2022-07-31 | Withdrawn(stopped due to Not as a lead unit) | |||
| Effects of a Physiotherapy Program in Patients Hospitalized Due to Pneumonia [NCT02515565] | 60 participants (Anticipated) | Interventional | 2015-09-30 | Recruiting | |||
| Erythromycin in Parkinson's Disease: A Pilot Study of Its Effects on Levodopa Pharmacokinetics and Pharmacodynamics [NCT02005029] | 18 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||