Proteins > Ephrin type-A receptor 8
Page last updated: 2024-08-07 23:25:09

Ephrin type-A receptor 8

An ephrin type-A receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29322]

Synonyms

EC 2.7.10.1;
EPH- and ELK-related kinase;
EPH-like kinase 3;
EK3;
hEK3;
Tyrosine-protein kinase receptor EEK

Research

Bioassay Publications (8)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Compounds (76)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC500.106122
birb 796Homo sapiens (human)IC501.000011
nvp-bhg712Homo sapiens (human)IC500.001210

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd1.633333
staurosporineHomo sapiens (human)Kd0.226733
gefitinibHomo sapiens (human)Kd1.800022
lestaurtinibHomo sapiens (human)Kd10.000022
vatalanibHomo sapiens (human)Kd10.000022
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd1.596733
birb 796Homo sapiens (human)Kd0.226733
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd0.940022
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd1.824055
pd 173955Homo sapiens (human)Kd0.005911
s 1033Homo sapiens (human)Kd0.037011
bms 387032Homo sapiens (human)Kd10.000022
tandutinibHomo sapiens (human)Kd10.000033
vx-745Homo sapiens (human)Kd7.700033
dasatinibHomo sapiens (human)Kd0.000222
zd 6474Homo sapiens (human)Kd0.114033
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd10.000022
bosutinibHomo sapiens (human)Kd0.009011
su 11248Homo sapiens (human)Kd10.000033
jnj-7706621Homo sapiens (human)Kd10.000011
vx680Homo sapiens (human)Kd0.500022
ekb 569Homo sapiens (human)Kd1.850022
axitinibHomo sapiens (human)Kd10.000011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd10.000033
ki 20227Homo sapiens (human)Kd3.900011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd5.300011
masitinibHomo sapiens (human)Kd1.800011
pazopanibHomo sapiens (human)Kd10.000022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd10.000022
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd3.900011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd1.300011
brivanibHomo sapiens (human)Kd10.000011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd0.018022
kw 2449Homo sapiens (human)Kd10.000011
abt 869Homo sapiens (human)Kd10.000022
gw 2580Homo sapiens (human)Kd10.000022
crizotinibHomo sapiens (human)Kd0.280011
chir-265Homo sapiens (human)Kd1.100022
motesanibHomo sapiens (human)Kd10.000022
mln8054Homo sapiens (human)Kd10.000022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd10.000022
nvp-tae684Homo sapiens (human)Kd10.000011
fedratinibHomo sapiens (human)Kd7.700011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd10.000011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd10.000022
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd0.001811
chir 258Homo sapiens (human)Kd10.000022
nintedanibHomo sapiens (human)Kd10.000011
pp242Homo sapiens (human)Kd0.250011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
ephrin receptor activitymolecular functionCombining with an ephrin receptor ligand to initiate a change in cell activity. [GOC:mah, PMID:9530499]
GPI-linked ephrin receptor activitymolecular functionCombining with a GPI-anchored ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
growth factor bindingmolecular functionBinding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. [GOC:curators]
transmembrane-ephrin receptor activitymolecular functionCombining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
early endosome membranecellular componentThe lipid bilayer surrounding an early endosome. [GOC:pz]
neuron projectioncellular componentA prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
dendritecellular componentA neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 12 target(s):

TargetCategoryDefinition
substrate-dependent cell migrationbiological processThe orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. [ISBN:0815316194, PMID:11944043, PMID:14657486]
cell adhesionbiological processThe attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
axon guidancebiological processThe chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
neuron remodelingbiological processThe developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. [GOC:hb]
regulation of cell adhesionbiological processAny process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. [GOC:mah]
neuron projection developmentbiological processThe process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:mah]
regulation of cell adhesion mediated by integrinbiological processAny process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]
positive regulation of MAPK cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
ephrin receptor signaling pathwaybiological processThe series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionbiological processAny process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
cellular response to follicle-stimulating hormone stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]