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Novel 9-Alkyl- and 9-Alkylidene-Substituted 1α,25-Dihydroxyvitamin D3 Analogues: Synthesis and Biological Examinations.Journal of medicinal chemistry, , Aug-13, Volume: 58, Issue:15, 2015
A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1α,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D3.Journal of medicinal chemistry, , May-10, Volume: 55, Issue:9, 2012
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Synthesis and biological activity of 2-(3'-hydroxypropylidene)-1α-hydroxy-19-norvitamin D analogues with shortened alkyl side chains.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D₃ markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription.Journal of medicinal chemistry, , Dec-23, Volume: 53, Issue:24, 2010
Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.Bioorganic & medicinal chemistry, , Nov-15, Volume: 17, Issue:22, 2009
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New 1alpha,25-dihydroxy-19-norvitamin D(3) compounds constrained in a single A-ring conformation: synthesis of the analogues by ring-closing metathesis route and their biological evaluation.Journal of medicinal chemistry, , Jun-11, Volume: 52, Issue:11, 2009
Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
2-Methylene 19-nor-25-dehydro-1alpha-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Design, synthesis, and biological evaluation of a 1alpha,25-dihydroxy-19-norvitamin D3 analogue with a frozen A-ring conformation.Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing.Journal of medicinal chemistry, , Apr-11, Volume: 45, Issue:8, 2002
Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998