Fibroblast growth factor receptor 2

A fibroblast growth factor receptor 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P21802]

Synonyms

FGFR-2;
EC 2.7.10.1;
K-sam;
KGFR;
Keratinocyte growth factor receptor

Research

Bioassay Publications (68)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (4.41)	18.2507
2000's	23 (33.82)	29.6817
2010's	28 (41.18)	24.3611
2020's	14 (20.59)	2.80

Compounds (105)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pd 173074	Homo sapiens (human)	IC50	2.6104	5	4
staurosporine	Homo sapiens (human)	IC50	0.0504	10	10
canertinib dihydrochloride	Homo sapiens (human)	IC50	50.0000	1	1
birb 796	Homo sapiens (human)	IC50	24.0000	1	1
tandutinib	Homo sapiens (human)	IC50	15.0850	2	2
pd 407824	Homo sapiens (human)	IC50	50.0000	1	1
pd 166285	Homo sapiens (human)	IC50	21.5220	2	2
pd 089828	Homo sapiens (human)	IC50	0.1300	3	3
pd 166866	Homo sapiens (human)	IC50	0.0600	3	3
pd 161570	Homo sapiens (human)	IC50	0.0480	2	2
semaxinib	Homo sapiens (human)	IC50	5.0000	1	1
pd 0183812	Homo sapiens (human)	IC50	8.6200	1	1
jnj-7706621	Homo sapiens (human)	IC50	31.6521	2	14
2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one	Homo sapiens (human)	IC50	1.2100	2	2
gdp 366	Homo sapiens (human)	IC50	4.2000	1	1
ki23057	Homo sapiens (human)	IC50	0.0785	2	2
ct52923	Homo sapiens (human)	IC50	160.0000	1	1
pazopanib	Homo sapiens (human)	IC50	0.1400	1	1
PDGF receptor tyrosine kinase inhibitor III	Homo sapiens (human)	IC50	29.7000	1	1
ki 8751	Homo sapiens (human)	IC50	0.1700	1	1
nvp-aew541	Homo sapiens (human)	IC50	2.7000	1	1
abt 869	Homo sapiens (human)	IC50	12.5000	1	1
azd 1152-hqpa	Homo sapiens (human)	Ki	10.0000	1	1
cudc 101	Homo sapiens (human)	IC50	3.4300	1	1
ponatinib	Homo sapiens (human)	IC50	0.0018	3	3
lucitanib	Homo sapiens (human)	IC50	0.0825	3	3
mk 2461	Homo sapiens (human)	IC50	0.0390	1	1
ly2874455	Homo sapiens (human)	IC50	0.0032	4	4
azd4547	Homo sapiens (human)	IC50	0.0052	16	16
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	Homo sapiens (human)	IC50	0.0010	5	5
bix 02565	Homo sapiens (human)	IC50	0.3200	2	1
ceritinib	Homo sapiens (human)	IC50	0.2600	1	1
debio 1347	Homo sapiens (human)	IC50	0.0076	3	3
pf-543	Homo sapiens (human)	IC50	10.0000	1	1
erdafitinib	Homo sapiens (human)	IC50	0.0037	8	7
at 9283	Homo sapiens (human)	IC50	0.0055	2	2
nintedanib	Homo sapiens (human)	IC50	0.0370	3	3

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sb 202190	Homo sapiens (human)	Kd	10.0000	1	1
imatinib	Homo sapiens (human)	Kd	10.0000	2	2
staurosporine	Homo sapiens (human)	Kd	0.1200	3	3
gefitinib	Homo sapiens (human)	Kd	10.0000	2	2
lestaurtinib	Homo sapiens (human)	Kd	0.6600	2	2
vatalanib	Homo sapiens (human)	Kd	10.0000	2	2
ruboxistaurin	Homo sapiens (human)	Kd	10.0000	2	2
canertinib	Homo sapiens (human)	Kd	10.0000	2	2
birb 796	Homo sapiens (human)	Kd	10.0000	2	2
cyc 202	Homo sapiens (human)	Kd	10.0000	1	1
sb 203580	Homo sapiens (human)	Kd	10.0000	2	2
enzastaurin	Homo sapiens (human)	Kd	10.0000	1	1
erlotinib	Homo sapiens (human)	Kd	7.3000	3	3
lapatinib	Homo sapiens (human)	Kd	10.0000	2	2
sorafenib	Homo sapiens (human)	Kd	2.7000	3	3
pd 173955	Homo sapiens (human)	Kd	0.0310	1	1
s 1033	Homo sapiens (human)	Kd	10.0000	1	1
bms 387032	Homo sapiens (human)	Kd	10.0000	2	2
tandutinib	Homo sapiens (human)	Kd	10.0000	3	3
vx-745	Homo sapiens (human)	Kd	10.0000	2	2
dasatinib	Homo sapiens (human)	Kd	1.4000	2	2
zd 6474	Homo sapiens (human)	Kd	2.5667	3	3
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
alvocidib	Homo sapiens (human)	Kd	10.0000	2	2
bosutinib	Homo sapiens (human)	Kd	10.0000	1	1
su 11248	Homo sapiens (human)	Kd	0.5540	5	5
jnj-7706621	Homo sapiens (human)	Kd	0.6800	1	1
vx680	Homo sapiens (human)	Kd	0.5700	2	2
ekb 569	Homo sapiens (human)	Kd	10.0000	1	1
axitinib	Homo sapiens (human)	Kd	0.1100	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
midostaurin	Homo sapiens (human)	Kd	2.4000	3	3
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
cp 724714	Homo sapiens (human)	Kd	10.0000	1	1
pi103	Homo sapiens (human)	Kd	10.0000	2	2
hki 272	Homo sapiens (human)	Kd	10.0000	1	1
tofacitinib	Homo sapiens (human)	Kd	10.0000	2	2
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	0.0350	1	1
masitinib	Homo sapiens (human)	Kd	10.0000	1	1
pazopanib	Homo sapiens (human)	Kd	0.2100	2	2
azd 6244	Homo sapiens (human)	Kd	10.0000	1	1
su 14813	Homo sapiens (human)	Kd	0.7900	2	2
bibw 2992	Homo sapiens (human)	Kd	10.0000	1	1
tg100-115	Homo sapiens (human)	Kd	10.0000	1	1
pha 665752	Homo sapiens (human)	Kd	5.2000	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	0.0730	1	1
brivanib	Homo sapiens (human)	Kd	0.1100	1	1
at 7519	Homo sapiens (human)	Kd	10.0000	1	1
bi 2536	Homo sapiens (human)	Kd	10.0000	1	1
nvp-ast487	Homo sapiens (human)	Kd	1.9000	2	2
kw 2449	Homo sapiens (human)	Kd	0.8500	1	1
abt 869	Homo sapiens (human)	Kd	10.0000	2	2
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
crizotinib	Homo sapiens (human)	Kd	10.0000	1	1
chir-265	Homo sapiens (human)	Kd	10.0000	2	2
motesanib	Homo sapiens (human)	Kd	10.0000	2	2
mln8054	Homo sapiens (human)	Kd	1.7000	2	2
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	10.0000	1	1
azd 1152-hqpa	Homo sapiens (human)	Kd	10.0000	2	2
nvp-tae684	Homo sapiens (human)	Kd	0.2500	1	1
fedratinib	Homo sapiens (human)	Kd	0.4700	1	1
gsk690693	Homo sapiens (human)	Kd	10.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	10.0000	1	1
plx 4720	Homo sapiens (human)	Kd	3.1000	1	1
sgx 523	Homo sapiens (human)	Kd	10.0000	1	1
quizartinib	Homo sapiens (human)	Kd	10.0000	2	2
incb-018424	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1363089	Homo sapiens (human)	Kd	0.8000	1	1
chir 258	Homo sapiens (human)	Kd	0.4100	2	2
nintedanib	Homo sapiens (human)	Kd	0.3500	1	1
pp242	Homo sapiens (human)	Kd	0.2100	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
adenosine	Homo sapiens (human)	Concentration	50.0000	1	1
brivanib	Homo sapiens (human)	Activity	0.2760	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
protein tyrosine kinase activity	molecular function	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]
fibroblast growth factor receptor activity	molecular function	Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
heparin binding	molecular function	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]
fibroblast growth factor binding	molecular function	Binding to a fibroblast growth factor. [PMID:9806903]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]

Located In

This protein is located in 10 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell cortex	cellular component	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. [GOC:mah, ISBN:0815316194]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
cytoplasmic vesicle	cellular component	A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]
excitatory synapse	cellular component	A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. [GOC:dph, GOC:ef]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 99 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
ureteric bud development	biological process	The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. [GOC:go_curators]
in utero embryonic development	biological process	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
epithelial to mesenchymal transition	biological process	A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:dph, PMID:14701881]
positive regulation of mesenchymal cell proliferation	biological process	The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. [GOC:dph]
outflow tract septum morphogenesis	biological process	The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. [GOC:mtg_heart]
membranous septum morphogenesis	biological process	The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. [GOC:mtg_heart]
endochondral bone growth	biological process	The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. [GOC:ascb_2009, GOC:dph, GOC:tb]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
cell-cell signaling	biological process	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
axonogenesis	biological process	De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
fibroblast growth factor receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GOC:ceb]
regulation of smoothened signaling pathway	biological process	Any process that modulates the frequency, rate or extent of smoothened signaling. [GOC:go_curators]
post-embryonic development	biological process	The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. [GOC:go_curators]
embryonic pattern specification	biological process	The process that results in the patterns of cell differentiation that will arise in an embryo. [GOC:go_curators, ISBN:0521436125]
animal organ morphogenesis	biological process	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
positive regulation of phospholipase activity	biological process	Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of keratinocyte proliferation	biological process	Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. [GOC:dph, GOC:tb]
morphogenesis of embryonic epithelium	biological process	The process in which the anatomical structures of embryonic epithelia are generated and organized. [GOC:jl]
peptidyl-tyrosine phosphorylation	biological process	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039]
orbitofrontal cortex development	biological process	The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
ventricular zone neuroblast division	biological process	The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
pyramidal neuron development	biological process	The progression of a pyramidal neuron from its initial formation to its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
gland morphogenesis	biological process	The process in which the anatomical structures of a gland are generated and organized. [GOC:isa_complete]
positive regulation of Wnt signaling pathway	biological process	Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. [GOC:dph, GOC:go_curators, GOC:tb]
bone mineralization	biological process	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354]
lung development	biological process	The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. [GOC:jid, UBERON:0002048]
epithelial cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751]
midbrain development	biological process	The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain]
otic vesicle formation	biological process	The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear. [GOC:dgh]
hair follicle morphogenesis	biological process	The process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln]
response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
lacrimal gland development	biological process	The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. [GOC:ln]
regulation of osteoblast proliferation	biological process	Any process that modulates the frequency, rate or extent of osteoblast proliferation. [GOC:mah]
organ growth	biological process	The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. [GOC:bf, ISBN:0471245208, ISBN:0721662544]
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	biological process	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow. [GOC:mtg_apoptosis, GOC:yaf]
fibroblast growth factor receptor signaling pathway involved in hemopoiesis	biological process	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis. [GOC:yaf]
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	biological process	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow. [GOC:yaf]
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	biological process	The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state. [GOC:yaf]
inner ear morphogenesis	biological process	The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. [GOC:jl, ISBN:0192801023]
odontogenesis	biological process	The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. [GOC:jl, GOC:mah]
positive regulation of MAPK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
cell fate commitment	biological process	The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. [ISBN:0716731185]
response to ethanol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]
regulation of osteoblast differentiation	biological process	Any process that modulates the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]
positive regulation of cell cycle	biological process	Any process that activates or increases the rate or extent of progression through the cell cycle. [GOC:go_curators]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
protein autophosphorylation	biological process	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]
lung alveolus development	biological process	The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. [GOC:mtg_lung, PMID:9751757]
mesodermal cell differentiation	biological process	The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. [GOC:dgh]
embryonic digestive tract morphogenesis	biological process	The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:go_curators]
embryonic organ morphogenesis	biological process	Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:jid]
digestive tract development	biological process	The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:go_curators]
embryonic organ development	biological process	Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:jid]
reproductive structure development	biological process	The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. [GOC:dph, GOC:isa_complete, GOC:jid]
embryonic cranial skeleton morphogenesis	biological process	The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. [GOC:dsf, GOC:jid, PMID:16049113]
skeletal system morphogenesis	biological process	The process in which the anatomical structures of the skeleton are generated and organized. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb]
epidermis morphogenesis	biological process	The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:jid, UBERON:0001003]
branching morphogenesis of a nerve	biological process	The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). [GOC:dgh, GOC:dph, GOC:jid]
mesenchymal cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. [GOC:dph, GOC:jid]
positive regulation of epithelial cell proliferation	biological process	Any process that activates or increases the rate or extent of epithelial cell proliferation. [GOC:ai]
regulation of smooth muscle cell differentiation	biological process	Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. [CL:0000192, GOC:ai]
positive regulation of cell division	biological process	Any process that activates or increases the frequency, rate or extent of cell division. [GOC:ai]
ventricular cardiac muscle tissue morphogenesis	biological process	The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. [GOC:devbiol]
positive regulation of cardiac muscle cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]
limb bud formation	biological process	The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable. [GOC:dgh, GOC:dph]
bone development	biological process	The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. [GOC:dph]
bone morphogenesis	biological process	The process in which bones are generated and organized. [GOC:dph]
branching involved in prostate gland morphogenesis	biological process	The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. [GOC:dph]
branching involved in salivary gland morphogenesis	biological process	The process in which the branching structure of the salivary gland is generated and organized. [GOC:dph]
bud elongation involved in lung branching	biological process	The process in which a bud in the lung grows out from the point where it is formed. [GOC:dph, GOC:mtg_lung]
lung lobe morphogenesis	biological process	The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. [GOC:dph]
lung-associated mesenchyme development	biological process	The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung. [GOC:dph, GOC:mtg_lung]
positive regulation of epithelial cell proliferation involved in lung morphogenesis	biological process	Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. [GOC:dph]
prostate gland morphogenesis	biological process	The process in which the anatomical structures of a prostate gland are generated and organized. [GOC:dph, PMID:18977204]
prostate epithelial cord elongation	biological process	The developmental growth process in which solid chords of prostate epithelium increase in length. [GOC:dph, PMID:18977204]
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	biological process	The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini. [GOC:dph, PMID:18977204]
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	biological process	The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate. [GOC:dph, PMID:18977204]
fibroblast growth factor receptor signaling pathway involved in mammary gland specification	biological process	The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes. [GOC:dph, PMID:16168142]
lateral sprouting from an epithelium	biological process	The process in which a branch forms along the side of an epithelium. [GOC:dph]
mammary gland bud formation	biological process	The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis. [GOC:dph, PMID:12558599]
epithelial cell proliferation involved in salivary gland morphogenesis	biological process	The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland. [GOC:dph, PMID:17336109]
branch elongation involved in salivary gland morphogenesis	biological process	The differential growth of the salivary branches along their axis, resulting in the growth of a branch. [GOC:dph]
branching involved in labyrinthine layer morphogenesis	biological process	The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. [GOC:dph, PMID:16916377]
regulation of morphogenesis of a branching structure	biological process	Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. [GOC:dph]
mesenchymal cell differentiation involved in lung development	biological process	The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. [GOC:dph]
mesenchymal cell proliferation involved in lung development	biological process	The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:dph]
regulation of ERK1 and ERK2 cascade	biological process	Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
cellular response to retinoic acid	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:mah]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
cellular response to transforming growth factor beta stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. [GOC:ecd, PMID:15451575]
positive regulation of canonical Wnt signaling pathway	biological process	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]
positive regulation of vascular associated smooth muscle cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
multicellular organism development	biological process	The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
cell surface receptor protein tyrosine kinase signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
positive regulation of kinase activity	biological process	Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]