Mono-benzyl phthalate (MBP) is a phthalate ester that is a colorless to light yellow liquid with a faint odor. It is used as a plasticizer in a variety of applications, including polyvinyl chloride (PVC) resins, adhesives, and sealants. MBP can be synthesized by the reaction of benzyl alcohol with phthalic anhydride. It is a known endocrine disruptor and has been shown to have adverse effects on the reproductive system of animals. MBP is of particular concern due to its potential to leach from plastic products and contaminate food and water. Studies have shown that MBP can be absorbed through the skin and can accumulate in the body. It is studied because of its potential health risks and environmental impacts. Research focuses on understanding its fate and transport in the environment, its potential to disrupt endocrine function, and its effects on human health.'
monobenzyl phthalate : A phthalic acid monoester resulting from the formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of benzyl alcohol. It is a major metabolite of the plasticiser butyl benzyl phthalate (BBP).
ID Source | ID |
---|---|
PubMed CID | 31736 |
CHEMBL ID | 1466083 |
CHEBI ID | 132612 |
SCHEMBL ID | 116566 |
MeSH ID | M0270210 |
Synonym |
---|
HMS1474K22 |
BIDD:PXR0040 |
benzene-1,2-dicarboxylic acid, mono(phenylmethyl) ester |
1,2-benzenedicarboxylic acid, mono(phenylmethyl) ester |
nsc 402008 |
mono-n-benzyl phthalate |
mono(phenylmethyl) 1,2-benzenedicarboxylate |
benzyl hydrogen phthalate |
phthalic acid, benzyl ester |
monobenzyl phthalate |
mono-benzyl phthalate |
einecs 219-771-1 |
CBDIVE_003018 |
bzbp |
1, mono(phenylmethyl) ester |
nsc402008 |
nsc-402008 |
2528-16-7 |
CHEMDIV3_000594 |
smr000054384 |
MLS000104449 |
benzene-1,2-dicarboxylic acid, monobenzyl ester |
2-[(benzyloxy)carbonyl]benzoic acid |
o-(benzyloxycarbonyl)benzoic acid |
CHEBI:132612 |
mbep |
AKOS001570006 |
BRD-K83275418-001-01-7 |
1,2-benzenedicarboxylic acid 1-(phenylmethyl) ester |
P1191 |
phthalic acid monobenzyl ester |
2-phenylmethoxycarbonylbenzoic acid |
A18530 |
2-(benzyloxycarbonyl)benzoic acid |
NCGC00080394-02 |
NCGC00254352-01 |
dtxcid7023938 |
dtxsid9043938 , |
tox21_300626 |
cas-2528-16-7 |
STK524189 |
HMS2300N14 |
27nm8bnv1k , |
unii-27nm8bnv1k |
1,2-benzenedicarboxylic acid, 1-(phenylmethyl) ester |
FT-0672455 |
FT-0634345 |
benzylhydrogenphthalat |
benzylhydrogenphthalat [who-dd] |
2-((benzyloxy)carbonyl)benzoic acid |
CHEMBL1466083 |
SCHEMBL116566 |
2-[(benzyloxy)carbonyl]benzoic acid # |
XIKIUQUXDNHBFR-UHFFFAOYSA-N |
mono-benzyl phthalate, analytical standard |
SR-01000399402-1 |
sr-01000399402 |
mfcd00020279 |
J-015907 |
CS-W012564 |
2-benzyloxycarbonylbenzoic acid |
mono benzyl phthalate |
F17052 |
AS-47938 |
Q26840961 |
1,2-benzenedicarboxylic acid, mono(phenylmethyl) ester (9ci); phthalic acid, benzyl ester (6ci,7ci,8ci); 2-[(benzyloxy)carbonyl]benzoic acid; benzyl hydrogen phthalate; monobenzyl phthalate; nsc 402008 |
phthalic acid, mono-benzyl ester |
HY-W011848 |
2-((benzyloxy)carbonyl)benzoicacid |
phthalic acid, mono-benzyl ester 100 microg/ml in methyl-tert-butyl ether |
monobenzyl phthalate (mbzp) |
Role | Description |
---|---|
xenoestrogen | A synthetic or semi-synthetic compound that has oestrogenic activity. |
xenobiotic metabolite | Any metabolite produced by metabolism of a xenobiotic compound. |
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Class | Description |
---|---|
phthalic acid monoester | A dicarboxylic acid monoester resulting from the formal condensation of an alcoholic or aromatic hydroxy group with just one of the two carboxy groups of phthalic acid. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Luciferase | Photinus pyralis (common eastern firefly) | Potency | 39.9149 | 0.0072 | 15.7588 | 89.3584 | AID1224835 |
RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 52.2038 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521; AID1159523 |
GLI family zinc finger 3 | Homo sapiens (human) | Potency | 25.7785 | 0.0007 | 14.5928 | 83.7951 | AID1259392 |
AR protein | Homo sapiens (human) | Potency | 42.3723 | 0.0002 | 21.2231 | 8,912.5098 | AID1259247; AID743042; AID743054 |
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 45.8055 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839; AID1224893 |
nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 3.1623 | 0.2818 | 9.7212 | 35.4813 | AID2326 |
retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 49.4197 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159553; AID1159555 |
estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 41.6466 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1224848; AID1224849; AID1259401; AID1259403 |
pregnane X nuclear receptor | Homo sapiens (human) | Potency | 61.1306 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982 |
estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 23.7954 | 0.0002 | 29.3054 | 16,493.5996 | AID1259244; AID1259248; AID1259383; AID743075; AID743080; AID743091 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 27.3060 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.4328 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 17.2289 | 0.0015 | 57.7890 | 15,848.9004 | AID1259244 |
Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 17.2289 | 0.0015 | 51.7393 | 15,848.9004 | AID1259244 |
ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 76.9588 | 0.0119 | 17.9420 | 71.5630 | AID651632 |
Ataxin-2 | Homo sapiens (human) | Potency | 76.9588 | 0.0119 | 12.2221 | 68.7989 | AID651632 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
protein binding | ATPase family AAA domain-containing protein 5 | Homo sapiens (human) |
ATP binding | ATPase family AAA domain-containing protein 5 | Homo sapiens (human) |
ATP hydrolysis activity | ATPase family AAA domain-containing protein 5 | Homo sapiens (human) |
DNA clamp unloader activity | ATPase family AAA domain-containing protein 5 | Homo sapiens (human) |
DNA binding | ATPase family AAA domain-containing protein 5 | Homo sapiens (human) |
RNA binding | Ataxin-2 | Homo sapiens (human) |
epidermal growth factor receptor binding | Ataxin-2 | Homo sapiens (human) |
protein binding | Ataxin-2 | Homo sapiens (human) |
mRNA binding | Ataxin-2 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
plasma membrane | Glutamate receptor 2 | Rattus norvegicus (Norway rat) |
Elg1 RFC-like complex | ATPase family AAA domain-containing protein 5 | Homo sapiens (human) |
nucleus | ATPase family AAA domain-containing protein 5 | Homo sapiens (human) |
cytoplasm | Ataxin-2 | Homo sapiens (human) |
Golgi apparatus | Ataxin-2 | Homo sapiens (human) |
trans-Golgi network | Ataxin-2 | Homo sapiens (human) |
cytosol | Ataxin-2 | Homo sapiens (human) |
cytoplasmic stress granule | Ataxin-2 | Homo sapiens (human) |
membrane | Ataxin-2 | Homo sapiens (human) |
perinuclear region of cytoplasm | Ataxin-2 | Homo sapiens (human) |
ribonucleoprotein complex | Ataxin-2 | Homo sapiens (human) |
cytoplasmic stress granule | Ataxin-2 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (2.44) | 18.2507 |
2000's | 6 (14.63) | 29.6817 |
2010's | 22 (53.66) | 24.3611 |
2020's | 12 (29.27) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.42) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 1 (2.33%) | 5.53% |
Reviews | 1 (2.33%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 41 (95.35%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |