Steroid 21-hydroxylase

A steroid 21-hydroxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08686]

EC 1.14.14.16;
21-OHase;
Cytochrome P-450c21;
Cytochrome P450 21;
Cytochrome P450 XXI;
Cytochrome P450-C21;
Cytochrome P450-C21B

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ketoconazole	Homo sapiens (human)	IC50	8.1700	2	3
abiraterone	Homo sapiens (human)	IC50	0.1642	2	1
17-(3-pyridyl)androsta-5,16-dien-3-one	Homo sapiens (human)	IC50	0.0007	1	1
orteronel	Homo sapiens (human)	IC50	4.8700	1	0
3beta-hydroxy-17-(1h-benzimidazole-1-yl)androsta-5,16-diene	Homo sapiens (human)	IC50	0.1626	2	1

This protein enables 7 target(s):

Target	Category	Definition
steroid 21-monooxygenase activity	molecular function	Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O. [RHEA:65612]
steroid binding	molecular function	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]
steroid hydroxylase activity	molecular function	Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. [ISBN:0721662544]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
17-hydroxyprogesterone 21-hydroxylase activity	molecular function	Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:pz, RHEA:50308]
progesterone 21-hydroxylase activity	molecular function	Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [PMID:25855791, RHEA:50304]

This protein is located in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is involved in 5 target(s):

Target	Category	Definition
steroid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators]
glucocorticoid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]
mineralocorticoid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]
steroid metabolic process	biological process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
sterol metabolic process	biological process	The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [ISBN:0198547684]