Cholesterol 24-hydroxylase

A cytochrome P450 46A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6A2]

Synonyms

CH24H;
EC 1.14.14.25;
Cholesterol 24-monooxygenase;
Cholesterol 24S-hydroxylase;
Cytochrome P450 46A1

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (100.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
voriconazole	Homo sapiens (human)	IC50	0.0345	2	0
voriconazole	Homo sapiens (human)	Ki	0.0110	1	0
pregnenolone sulfate	Homo sapiens (human)	Ki	2.5000	1	0
thioperamide	Homo sapiens (human)	IC50	0.4300	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
efavirenz	Homo sapiens (human)	Kd	5.3333	3	3
cholesteryl sulfate	Homo sapiens (human)	Kd	0.0500	1	0
voriconazole	Homo sapiens (human)	Kd	0.0500	1	0
8-hydroxyefavirenz	Homo sapiens (human)	Kd	7.3000	2	2

Enables

This protein enables 5 target(s):

Target	Category	Definition
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]
steroid hydroxylase activity	molecular function	Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. [ISBN:0721662544]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
cholesterol 24-hydroxylase activity	molecular function	Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+. [EC:1.14.14.25, RHEA:22716]
testosterone 16-beta-hydroxylase activity	molecular function	Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [PMID:21289075, RHEA:46304]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]
postsynapse	cellular component	The part of a synapse that is part of the post-synaptic cell. [GOC:dos]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
bile acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC:go_curators]
cholesterol catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
nervous system development	biological process	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
sterol metabolic process	biological process	The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [ISBN:0198547684]
progesterone metabolic process	biological process	The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/]
regulation of long-term synaptic potentiation	biological process	Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]