Proteins > 5-hydroxytryptamine receptor 1A
Page last updated: 2024-08-07 16:07:05
5-hydroxytryptamine receptor 1A
A 5-hydroxytryptamine receptor 1A that is encoded in the genome of rat. [OMA:P19327, PRO:DNx]
Synonyms
5-HT-1A;
5-HT1A;
Serotonin receptor 1A
Research
Bioassay Publications (188)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 27 (14.36) | 18.7374 |
| 1990's | 90 (47.87) | 18.2507 |
| 2000's | 46 (24.47) | 29.6817 |
| 2010's | 21 (11.17) | 24.3611 |
| 2020's | 4 (2.13) | 2.80 |
Compounds (333)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tryptamine | Rattus norvegicus (Norway rat) | Ki | 0.1698 | 1 | 1 |
| 7-hydroxy-2-n,n-dipropylaminotetralin | Rattus norvegicus (Norway rat) | Ki | 2.8100 | 1 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | IC50 | 0.0032 | 5 | 6 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 0.1796 | 32 | 35 |
| 1-(1-naphthyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0080 | 2 | 2 |
| 1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.1397 | 6 | 7 |
| 1-(3-chlorophenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.1117 | 5 | 5 |
| 2-methyl-5-ht | Rattus norvegicus (Norway rat) | Ki | 1.8559 | 2 | 2 |
| 3-nitrobenzeneboronic acid | Rattus norvegicus (Norway rat) | IC50 | 200.0000 | 1 | 1 |
| phenytoin | Rattus norvegicus (Norway rat) | Ki | 155.0000 | 1 | 1 |
| 5-carboxamidotryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| methylbufotenin | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| methylbufotenin | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 6 | 6 |
| 5-methoxytryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0048 | 5 | 5 |
| acebutolol | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| alpha-methylserotonin | Rattus norvegicus (Norway rat) | Ki | 0.0656 | 2 | 2 |
| alprenolol | Rattus norvegicus (Norway rat) | IC50 | 0.0049 | 1 | 1 |
| alprenolol | Rattus norvegicus (Norway rat) | Ki | 0.1175 | 1 | 1 |
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 1.0200 | 2 | 1 |
| amitriptyline | Rattus norvegicus (Norway rat) | Ki | 1.1410 | 1 | 0 |
| astemizole | Rattus norvegicus (Norway rat) | IC50 | 0.7670 | 1 | 0 |
| astemizole | Rattus norvegicus (Norway rat) | Ki | 0.4380 | 1 | 0 |
| atenolol | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| benzo(b)thiophene-2-boronic acid | Rattus norvegicus (Norway rat) | IC50 | 2.6000 | 2 | 2 |
| bithionol | Rattus norvegicus (Norway rat) | IC50 | 5.5150 | 1 | 0 |
| bithionol | Rattus norvegicus (Norway rat) | Ki | 3.1520 | 1 | 0 |
| bmy 7378 | Rattus norvegicus (Norway rat) | Ki | 0.0279 | 2 | 3 |
| brimonidine | Rattus norvegicus (Norway rat) | IC50 | 2.5510 | 1 | 0 |
| brimonidine | Rattus norvegicus (Norway rat) | Ki | 1.4580 | 1 | 0 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 0.1888 | 6 | 5 |
| buspirone | Rattus norvegicus (Norway rat) | Ki | 0.0162 | 9 | 9 |
| verapamil | Rattus norvegicus (Norway rat) | IC50 | 3.0200 | 1 | 0 |
| verapamil | Rattus norvegicus (Norway rat) | Ki | 1.7260 | 1 | 0 |
| candesartan | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| carvedilol | Rattus norvegicus (Norway rat) | IC50 | 0.0058 | 1 | 0 |
| carvedilol | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 2 | 1 |
| celecoxib | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 1 | 1 |
| celiprolol | Rattus norvegicus (Norway rat) | Ki | 8.9125 | 1 | 1 |
| cgp 20712a | Rattus norvegicus (Norway rat) | Ki | 0.6026 | 1 | 1 |
| cgs 12066 | Rattus norvegicus (Norway rat) | IC50 | 0.0190 | 1 | 2 |
| cgs 12066 | Rattus norvegicus (Norway rat) | Ki | 0.0096 | 1 | 1 |
| chlordiazepoxide | Rattus norvegicus (Norway rat) | IC50 | 1.1000 | 1 | 1 |
| chlorpromazine | Rattus norvegicus (Norway rat) | IC50 | 4.6850 | 1 | 0 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 2.6770 | 1 | 0 |
| cisapride | Rattus norvegicus (Norway rat) | IC50 | 3.6495 | 2 | 1 |
| cisapride | Rattus norvegicus (Norway rat) | Ki | 5.8085 | 2 | 1 |
| citalopram | Rattus norvegicus (Norway rat) | Ki | 50.1187 | 1 | 1 |
| clenbuterol | Rattus norvegicus (Norway rat) | IC50 | 2.6520 | 1 | 0 |
| clenbuterol | Rattus norvegicus (Norway rat) | Ki | 1.5150 | 1 | 0 |
| clomipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| clonidine | Rattus norvegicus (Norway rat) | IC50 | 5.3650 | 1 | 0 |
| clonidine | Rattus norvegicus (Norway rat) | Ki | 3.0660 | 1 | 0 |
| clotrimazole | Rattus norvegicus (Norway rat) | IC50 | 17.6880 | 1 | 0 |
| clotrimazole | Rattus norvegicus (Norway rat) | Ki | 10.1080 | 1 | 0 |
| cyproheptadine | Rattus norvegicus (Norway rat) | IC50 | 0.1220 | 1 | 0 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 1 | 0 |
| desipramine | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| nordazepam | Rattus norvegicus (Norway rat) | Ki | 73.0000 | 1 | 1 |
| amphetamine | Rattus norvegicus (Norway rat) | Ki | 7.6600 | 1 | 1 |
| diazepam | Rattus norvegicus (Norway rat) | IC50 | 0.0227 | 2 | 2 |
| diazepam | Rattus norvegicus (Norway rat) | Ki | 42.5030 | 2 | 2 |
| donepezil | Rattus norvegicus (Norway rat) | IC50 | 7.4200 | 1 | 1 |
| doxepin | Rattus norvegicus (Norway rat) | IC50 | 0.8595 | 2 | 1 |
| doxepin | Rattus norvegicus (Norway rat) | Ki | 0.8680 | 1 | 0 |
| droperidol | Rattus norvegicus (Norway rat) | IC50 | 0.2420 | 1 | 0 |
| droperidol | Rattus norvegicus (Norway rat) | Ki | 0.1380 | 1 | 0 |
| econazole | Rattus norvegicus (Norway rat) | IC50 | 16.1770 | 1 | 0 |
| econazole | Rattus norvegicus (Norway rat) | Ki | 9.2440 | 1 | 0 |
| fluphenazine | Rattus norvegicus (Norway rat) | IC50 | 1.6440 | 1 | 0 |
| fluphenazine | Rattus norvegicus (Norway rat) | Ki | 0.9390 | 1 | 0 |
| flumazenil | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| glyburide | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| granisetron | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 2 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 3.2030 | 5 | 6 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 1.7748 | 7 | 7 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| staurosporine aglycone | Rattus norvegicus (Norway rat) | IC50 | 8.0000 | 1 | 1 |
| ketanserin | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 2 | 2 |
| ketotifen | Rattus norvegicus (Norway rat) | IC50 | 2.5370 | 1 | 0 |
| ketotifen | Rattus norvegicus (Norway rat) | Ki | 1.4500 | 1 | 0 |
| labetalol | Rattus norvegicus (Norway rat) | IC50 | 0.3930 | 1 | 0 |
| labetalol | Rattus norvegicus (Norway rat) | Ki | 0.2250 | 1 | 0 |
| losartan | Rattus norvegicus (Norway rat) | IC50 | 0.0190 | 1 | 1 |
| metoclopramide | Rattus norvegicus (Norway rat) | IC50 | 7.8000 | 1 | 1 |
| metoprolol | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 2.9360 | 2 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 0.7260 | 3 | 2 |
| miconazole | Rattus norvegicus (Norway rat) | IC50 | 11.4720 | 1 | 0 |
| miconazole | Rattus norvegicus (Norway rat) | Ki | 6.5550 | 1 | 0 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | IC50 | 0.2900 | 1 | 2 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.1344 | 6 | 6 |
| nan 190 | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 8 | 9 |
| nefazodone | Rattus norvegicus (Norway rat) | Ki | 0.0520 | 1 | 1 |
| nicardipine | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| nitrazepam | Rattus norvegicus (Norway rat) | IC50 | 0.0380 | 1 | 1 |
| nortriptyline | Rattus norvegicus (Norway rat) | IC50 | 1.0190 | 2 | 1 |
| nortriptyline | Rattus norvegicus (Norway rat) | Ki | 1.0680 | 1 | 0 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| oxprenolol | Rattus norvegicus (Norway rat) | Ki | 0.0933 | 1 | 1 |
| oxymetazoline | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 0 |
| oxymetazoline | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 0 |
| moxonidine | Rattus norvegicus (Norway rat) | IC50 | 0.7021 | 1 | 0 |
| moxonidine | Rattus norvegicus (Norway rat) | Ki | 0.4012 | 1 | 0 |
| pindolol | Rattus norvegicus (Norway rat) | IC50 | 0.0480 | 1 | 0 |
| pindolol | Rattus norvegicus (Norway rat) | Ki | 0.0496 | 3 | 2 |
| pirenzepine | Rattus norvegicus (Norway rat) | Ki | 0.0479 | 1 | 1 |
| prazosin | Rattus norvegicus (Norway rat) | Ki | 0.6347 | 3 | 3 |
| prochlorperazine | Rattus norvegicus (Norway rat) | IC50 | 0.9500 | 1 | 0 |
| prochlorperazine | Rattus norvegicus (Norway rat) | Ki | 0.5430 | 1 | 0 |
| promazine | Rattus norvegicus (Norway rat) | IC50 | 5.1720 | 1 | 0 |
| promazine | Rattus norvegicus (Norway rat) | Ki | 2.9550 | 1 | 0 |
| promethazine | Rattus norvegicus (Norway rat) | IC50 | 2.5960 | 1 | 0 |
| promethazine | Rattus norvegicus (Norway rat) | Ki | 1.4840 | 1 | 0 |
| propafenone | Rattus norvegicus (Norway rat) | IC50 | 1.6370 | 1 | 0 |
| propafenone | Rattus norvegicus (Norway rat) | Ki | 0.9350 | 1 | 0 |
| propranolol | Rattus norvegicus (Norway rat) | IC50 | 0.0827 | 3 | 3 |
| propranolol | Rattus norvegicus (Norway rat) | Ki | 0.1390 | 1 | 0 |
| quetiapine | Rattus norvegicus (Norway rat) | IC50 | 1.4264 | 1 | 0 |
| quetiapine | Rattus norvegicus (Norway rat) | Ki | 0.8151 | 1 | 0 |
| quipazine | Rattus norvegicus (Norway rat) | IC50 | 2.7000 | 1 | 1 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.4752 | 3 | 4 |
| risperidone | Rattus norvegicus (Norway rat) | IC50 | 0.7990 | 1 | 0 |
| risperidone | Rattus norvegicus (Norway rat) | Ki | 0.3690 | 6 | 5 |
| ritanserin | Rattus norvegicus (Norway rat) | Ki | 0.5145 | 2 | 2 |
| ro 15-4513 | Rattus norvegicus (Norway rat) | Ki | 0.0053 | 1 | 1 |
| sb 206553 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 0.0742 | 4 | 4 |
| spiroxatrine | Rattus norvegicus (Norway rat) | Ki | 0.0114 | 1 | 2 |
| vorinostat | Rattus norvegicus (Norway rat) | IC50 | 0.0530 | 1 | 1 |
| sulconazole | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| sumatriptan | Rattus norvegicus (Norway rat) | IC50 | 0.7220 | 2 | 1 |
| sumatriptan | Rattus norvegicus (Norway rat) | Ki | 0.4590 | 1 | 0 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.0600 | 1 | 0 |
| thioridazine | Rattus norvegicus (Norway rat) | Ki | 0.0340 | 1 | 0 |
| trazodone | Rattus norvegicus (Norway rat) | IC50 | 0.3110 | 1 | 0 |
| trazodone | Rattus norvegicus (Norway rat) | Ki | 0.2009 | 2 | 1 |
| triazolam | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| n-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-n-(2-pyridinyl)cyclohexanecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 0.0042 | 1 | 1 |
| wb 4101 | Rattus norvegicus (Norway rat) | Ki | 0.0073 | 1 | 1 |
| lysergic acid diethylamide | Rattus norvegicus (Norway rat) | Ki | 0.0051 | 2 | 2 |
| dichloroisoproterenol | Rattus norvegicus (Norway rat) | IC50 | 0.9772 | 1 | 3 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Ki | 0.2590 | 1 | 1 |
| phenylpiperazine | Rattus norvegicus (Norway rat) | Ki | 0.5001 | 6 | 7 |
| ergotamine | Rattus norvegicus (Norway rat) | IC50 | 0.0008 | 1 | 0 |
| ergotamine | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 0 |
| methylergonovine | Rattus norvegicus (Norway rat) | IC50 | 0.0041 | 1 | 0 |
| methylergonovine | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 0 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 64.6000 | 1 | 1 |
| dibenzothiazyl disulfide | Rattus norvegicus (Norway rat) | IC50 | 0.7470 | 1 | 0 |
| dibenzothiazyl disulfide | Rattus norvegicus (Norway rat) | Ki | 0.4270 | 1 | 0 |
| sterogenol | Rattus norvegicus (Norway rat) | IC50 | 2.8310 | 1 | 0 |
| sterogenol | Rattus norvegicus (Norway rat) | Ki | 1.6180 | 1 | 0 |
| yohimbine | Rattus norvegicus (Norway rat) | IC50 | 0.1260 | 1 | 0 |
| yohimbine | Rattus norvegicus (Norway rat) | Ki | 0.0403 | 2 | 1 |
| indopan | Rattus norvegicus (Norway rat) | Ki | 0.5300 | 1 | 1 |
| methysergide | Rattus norvegicus (Norway rat) | IC50 | 0.0540 | 1 | 0 |
| methysergide | Rattus norvegicus (Norway rat) | Ki | 0.0310 | 1 | 0 |
| bufotenin | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| dihydroergotamine | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 0 |
| dihydroergotamine | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 0 |
| congo red | Rattus norvegicus (Norway rat) | IC50 | 4.0000 | 1 | 1 |
| lysergol | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 1 |
| fluanisone | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| dexpropranolol | Rattus norvegicus (Norway rat) | IC50 | 4.8800 | 1 | 0 |
| dexpropranolol | Rattus norvegicus (Norway rat) | Ki | 2.7890 | 1 | 0 |
| n,n-dimethylphenylethylamine | Rattus norvegicus (Norway rat) | Ki | 0.8500 | 1 | 1 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Ki | 4.5700 | 1 | 1 |
| metergoline | Rattus norvegicus (Norway rat) | IC50 | 0.0062 | 1 | 0 |
| metergoline | Rattus norvegicus (Norway rat) | Ki | 0.0118 | 2 | 1 |
| lisuride | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 0 |
| lisuride | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 0 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Ki | 46.4000 | 1 | 1 |
| bromocriptine | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 0 |
| bromocriptine | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 0 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 79.4000 | 1 | 1 |
| lenperone | Rattus norvegicus (Norway rat) | Ki | 0.3050 | 1 | 1 |
| timolol | Rattus norvegicus (Norway rat) | IC50 | 2.7120 | 1 | 0 |
| timolol | Rattus norvegicus (Norway rat) | Ki | 1.0833 | 2 | 1 |
| 5,7-dihydroxytryptamine | Rattus norvegicus (Norway rat) | Ki | 6.7721 | 1 | 2 |
| buspirone hydrochloride | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| 5-methoxy-alpha-methyltryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 1 | 1 |
| tertatolol | Rattus norvegicus (Norway rat) | Ki | 0.0186 | 1 | 1 |
| penbutolol | Rattus norvegicus (Norway rat) | Ki | 0.0024 | 1 | 1 |
| levobunolol | Rattus norvegicus (Norway rat) | IC50 | 2.9010 | 1 | 0 |
| levobunolol | Rattus norvegicus (Norway rat) | Ki | 1.6580 | 1 | 0 |
| n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| bopindolol | Rattus norvegicus (Norway rat) | IC50 | 0.2670 | 1 | 0 |
| bopindolol | Rattus norvegicus (Norway rat) | Ki | 0.1530 | 1 | 0 |
| indalpine | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 2 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 2 | 1 |
| pergolide | Rattus norvegicus (Norway rat) | Ki | 0.0085 | 1 | 0 |
| quinpirole | Rattus norvegicus (Norway rat) | Ki | 1.5000 | 1 | 1 |
| mifepristone | Rattus norvegicus (Norway rat) | IC50 | 0.0014 | 1 | 1 |
| ipsapirone | Rattus norvegicus (Norway rat) | IC50 | 0.0082 | 1 | 1 |
| ipsapirone | Rattus norvegicus (Norway rat) | Ki | 0.0034 | 2 | 2 |
| niguldipine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| mibefradil | Rattus norvegicus (Norway rat) | IC50 | 1.3400 | 1 | 1 |
| fananserin | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 2 | 2 |
| aripiprazole | Rattus norvegicus (Norway rat) | Ki | 0.0198 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Ki | 3.3400 | 1 | 1 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 1.0200 | 1 | 1 |
| divaplon | Rattus norvegicus (Norway rat) | IC50 | 0.0560 | 1 | 1 |
| eltoprazine | Rattus norvegicus (Norway rat) | Ki | 0.0246 | 2 | 2 |
| lerisetron | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 2 |
| dexfenfluramine | Rattus norvegicus (Norway rat) | IC50 | 3.4030 | 1 | 0 |
| dexfenfluramine | Rattus norvegicus (Norway rat) | Ki | 1.9440 | 1 | 0 |
| spiramide | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 1 |
| etisulergine | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 2 | 2 |
| spirodecanone | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| sarmazenil | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| ubenimex | Rattus norvegicus (Norway rat) | IC50 | 120.4000 | 1 | 1 |
| ergocornine | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 1 | 0 |
| ergocornine | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 0 |
| agroclavine | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| iodophthalein | Rattus norvegicus (Norway rat) | IC50 | 3.0000 | 1 | 1 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Ki | 2.8900 | 1 | 1 |
| kampirone | Rattus norvegicus (Norway rat) | Ki | 1.4125 | 1 | 1 |
| n,n-dipropyl-2-aminotetralin | Rattus norvegicus (Norway rat) | Ki | 0.0466 | 2 | 2 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Ki | 14.1000 | 1 | 1 |
| 6-chloro-2-(1-piperazinyl)pyrazine | Rattus norvegicus (Norway rat) | Ki | 0.6530 | 3 | 3 |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | Rattus norvegicus (Norway rat) | IC50 | 0.0107 | 2 | 3 |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | Rattus norvegicus (Norway rat) | Ki | 0.0087 | 3 | 4 |
| alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol | Rattus norvegicus (Norway rat) | IC50 | 0.9100 | 2 | 2 |
| exp3174 | Rattus norvegicus (Norway rat) | IC50 | 0.0013 | 1 | 1 |
| ro 15-3505 | Rattus norvegicus (Norway rat) | Ki | 0.0054 | 1 | 1 |
| way 100135 | Rattus norvegicus (Norway rat) | IC50 | 0.0339 | 1 | 1 |
| mosapride | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| bms 180448 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| uh 301 | Rattus norvegicus (Norway rat) | Ki | 0.0520 | 1 | 2 |
| a 68930 | Rattus norvegicus (Norway rat) | Ki | 2.5500 | 1 | 1 |
| tazobactam | Rattus norvegicus (Norway rat) | IC50 | 0.8300 | 1 | 1 |
| sk&f 86466 | Rattus norvegicus (Norway rat) | Ki | 0.1000 | 1 | 1 |
| cp 93129 | Rattus norvegicus (Norway rat) | IC50 | 3.0000 | 1 | 2 |
| l 687384 | Rattus norvegicus (Norway rat) | IC50 | 50.5000 | 2 | 2 |
| mcn 5707 | Rattus norvegicus (Norway rat) | Ki | 4.5267 | 1 | 3 |
| ro 19-4603 | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| ro 14-7437 | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| ro 14-7437 | Rattus norvegicus (Norway rat) | Ki | 0.0013 | 1 | 1 |
| vb 20b7 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| sulbactam | Rattus norvegicus (Norway rat) | IC50 | 65.9000 | 1 | 1 |
| exp7711 | Rattus norvegicus (Norway rat) | IC50 | 5.5495 | 1 | 2 |
| 3-propylamino-5-hydroxychroman | Rattus norvegicus (Norway rat) | Ki | 0.0425 | 2 | 2 |
| s 14671 | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| cyclazosin | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| sc 53116 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| 4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 1 |
| u 93385 | Rattus norvegicus (Norway rat) | Ki | 0.0019 | 1 | 1 |
| tripitramine | Rattus norvegicus (Norway rat) | Ki | 0.1479 | 1 | 1 |
| 4-(3-(benzotriazol-1-yl)propyl)-1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 2 | 2 |
| sonepiprazole | Rattus norvegicus (Norway rat) | Ki | 3.7000 | 1 | 1 |
| dilevalol | Rattus norvegicus (Norway rat) | Ki | 0.2951 | 1 | 1 |
| alpha-ergocryptine | Rattus norvegicus (Norway rat) | IC50 | 0.0026 | 1 | 0 |
| alpha-ergocryptine | Rattus norvegicus (Norway rat) | Ki | 0.0015 | 1 | 0 |
| 4-hydroxy-2-(di-n-propylamino)indan | Rattus norvegicus (Norway rat) | Ki | 0.0195 | 1 | 1 |
| n-dansyl-3-aminobenzeneboronic acid | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| n-methylserotonin | Rattus norvegicus (Norway rat) | Ki | 0.0049 | 1 | 1 |
| 3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole | Rattus norvegicus (Norway rat) | Ki | 0.1454 | 2 | 3 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 2.6600 | 1 | 1 |
| homonojirimycin | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 1 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| 6-hydroxytryptamine | Rattus norvegicus (Norway rat) | Ki | 1.5849 | 1 | 1 |
| n,n-di-n-propylserotonin | Rattus norvegicus (Norway rat) | Ki | 0.0071 | 1 | 1 |
| 8-(di-n-propylamino)-6,7,8,9-tetrahydro-3h-benz(e)indole-1-carbaldehyde | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 5 | 5 |
| tak 779 | Rattus norvegicus (Norway rat) | Ki | 0.0245 | 2 | 2 |
| zg 63 | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| 8-methoxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 0.0017 | 3 | 3 |
| maduramicin | Rattus norvegicus (Norway rat) | IC50 | 0.0078 | 1 | 0 |
| maduramicin | Rattus norvegicus (Norway rat) | Ki | 0.0045 | 1 | 0 |
| bifeprunox | Rattus norvegicus (Norway rat) | Ki | 0.0646 | 1 | 1 |
| roxindole | Rattus norvegicus (Norway rat) | IC50 | 0.0008 | 1 | 1 |
| saquinavir | Rattus norvegicus (Norway rat) | IC50 | 4.2730 | 1 | 0 |
| saquinavir | Rattus norvegicus (Norway rat) | Ki | 2.4420 | 1 | 0 |
| cromakalim | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| ergonovine | Rattus norvegicus (Norway rat) | IC50 | 0.0081 | 1 | 0 |
| ergonovine | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 1 | 0 |
| dironyl | Rattus norvegicus (Norway rat) | IC50 | 0.0250 | 1 | 1 |
| dihydroergocristine monomesylate | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 0 |
| dihydroergocristine monomesylate | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 0 |
| tretinoin | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| t0901317 | Rattus norvegicus (Norway rat) | Ki | 0.0260 | 1 | 1 |
| 1,4-dideoxy-1,4-imino-d-arabinitol | Rattus norvegicus (Norway rat) | IC50 | 8.4000 | 1 | 1 |
| 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | Rattus norvegicus (Norway rat) | IC50 | 0.5435 | 1 | 0 |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | Rattus norvegicus (Norway rat) | Ki | 0.3106 | 1 | 0 |
| ipratropium bromide anhydrous | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| (S)-(-)-pindolol | Rattus norvegicus (Norway rat) | IC50 | 0.0280 | 1 | 0 |
| (S)-(-)-pindolol | Rattus norvegicus (Norway rat) | Ki | 0.0160 | 1 | 0 |
| n-phenyl-n'-2-pyridylthiourea | Rattus norvegicus (Norway rat) | IC50 | 23.3600 | 1 | 1 |
| 1-(2,5-dimethoxyphenyl)-3-phenylthiourea | Rattus norvegicus (Norway rat) | IC50 | 29.9300 | 1 | 1 |
| flunarizine | Rattus norvegicus (Norway rat) | IC50 | 4.2810 | 1 | 0 |
| flunarizine | Rattus norvegicus (Norway rat) | Ki | 2.4460 | 1 | 0 |
| cinnarizine | Rattus norvegicus (Norway rat) | IC50 | 1.0830 | 1 | 0 |
| cinnarizine | Rattus norvegicus (Norway rat) | Ki | 0.6190 | 1 | 0 |
| thiourea | Rattus norvegicus (Norway rat) | IC50 | 21.0000 | 1 | 1 |
| tamoxifen | Rattus norvegicus (Norway rat) | IC50 | 12.1600 | 1 | 0 |
| tamoxifen | Rattus norvegicus (Norway rat) | Ki | 6.9490 | 1 | 0 |
| cid 2858522 | Rattus norvegicus (Norway rat) | IC50 | 3.0000 | 1 | 1 |
| bms 387032 | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 1 |
| dapiprazole | Rattus norvegicus (Norway rat) | IC50 | 2.0600 | 1 | 0 |
| dapiprazole | Rattus norvegicus (Norway rat) | Ki | 1.1770 | 1 | 0 |
| panadiplon | Rattus norvegicus (Norway rat) | Ki | 0.0016 | 1 | 1 |
| mcn 5652 | Rattus norvegicus (Norway rat) | Ki | 0.9025 | 1 | 2 |
| 5-methoxy-3-(di-n-propylamino)chroman | Rattus norvegicus (Norway rat) | Ki | 0.0100 | 1 | 1 |
| pm 1000 | Rattus norvegicus (Norway rat) | Ki | 0.1082 | 2 | 2 |
| quinagolide | Rattus norvegicus (Norway rat) | IC50 | 5.6000 | 2 | 4 |
| n-(2-(4-(4-chlorophenyl)piperazin-1-yl)ethyl)-3-methoxybenzamide | Rattus norvegicus (Norway rat) | Ki | 0.1470 | 1 | 1 |
| mm 77 | Rattus norvegicus (Norway rat) | Ki | 0.0064 | 1 | 1 |
| 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione | Rattus norvegicus (Norway rat) | Ki | 1,857,675,000,000,000.0000 | 2 | 2 |
| 2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-6,7,8,8a-tetrahydro-5H-imidazo[1,5-a]pyridine-1,3-dione | Rattus norvegicus (Norway rat) | Ki | 0.0455 | 1 | 1 |
| bw 723c86 | Rattus norvegicus (Norway rat) | IC50 | 1.1278 | 1 | 0 |
| bw 723c86 | Rattus norvegicus (Norway rat) | Ki | 0.6445 | 1 | 0 |
| quercetin | Rattus norvegicus (Norway rat) | IC50 | 4.0000 | 1 | 1 |
| rottlerin | Rattus norvegicus (Norway rat) | IC50 | 1.2000 | 1 | 1 |
| fenretinide | Rattus norvegicus (Norway rat) | Ki | 2.8000 | 1 | 1 |
| 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin | Rattus norvegicus (Norway rat) | IC50 | 0.0036 | 1 | 1 |
| fr 173657 | Rattus norvegicus (Norway rat) | IC50 | 0.0014 | 1 | 1 |
| fr 190997 | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 1 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 2.1000 | 1 | 1 |
| bradyzide | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| romidepsin | Rattus norvegicus (Norway rat) | IC50 | 0.0390 | 1 | 1 |
| oxiconazole | Rattus norvegicus (Norway rat) | IC50 | 5.5774 | 1 | 0 |
| oxiconazole | Rattus norvegicus (Norway rat) | Ki | 3.1871 | 1 | 0 |
| bakuchiol | Rattus norvegicus (Norway rat) | IC50 | 6.1000 | 1 | 1 |
| cinanserin | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| cp 135807 | Rattus norvegicus (Norway rat) | IC50 | 0.0330 | 1 | 1 |
| guanabenz | Rattus norvegicus (Norway rat) | IC50 | 2.0680 | 1 | 0 |
| guanabenz | Rattus norvegicus (Norway rat) | Ki | 1.1810 | 1 | 0 |
| dihydrexidine | Rattus norvegicus (Norway rat) | Ki | 1.5000 | 1 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 3 | 3 |
| 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| icatibant | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| vilazodone | Rattus norvegicus (Norway rat) | IC50 | 0.0003 | 1 | 1 |
| sarizotan | Rattus norvegicus (Norway rat) | Ki | 0.0022 | 1 | 1 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| bms 191095 | Rattus norvegicus (Norway rat) | IC50 | 0.4800 | 1 | 1 |
| lu 28-179 | Rattus norvegicus (Norway rat) | IC50 | 21.0000 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 2.2950 | 1 | 2 |
| ap 2238 | Rattus norvegicus (Norway rat) | IC50 | 48.9000 | 1 | 1 |
| f 13640 | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 1 | 1 |
| vn2222 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| slv 313 | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| u 92016a | Rattus norvegicus (Norway rat) | Ki | 0.0017 | 1 | 1 |
| pnu 96415e | Rattus norvegicus (Norway rat) | Ki | 0.1200 | 1 | 1 |
| tofacitinib | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| n,n-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride | Rattus norvegicus (Norway rat) | IC50 | 6.4600 | 1 | 1 |
| rs 504393 | Rattus norvegicus (Norway rat) | Ki | 0.2918 | 2 | 2 |
| sb-656104-a | Rattus norvegicus (Norway rat) | Ki | 0.2188 | 1 | 1 |
| 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole | Rattus norvegicus (Norway rat) | IC50 | 0.6600 | 1 | 1 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 5.0200 | 2 | 2 |
| kaspar | Rattus norvegicus (Norway rat) | Ki | 0.0386 | 1 | 1 |
| naluzotan | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 1 |
| tiotropium bromide | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| 2,5-dimethoxy-4-methylamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 3.5500 | 1 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, (r)-isomer, | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| brexpiprazole | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 4.2000 | 1 | 2 |
| kys 05090 | Rattus norvegicus (Norway rat) | IC50 | 0.0410 | 1 | 1 |
| tazobactam sodium | Rattus norvegicus (Norway rat) | IC50 | 25.1350 | 2 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| bms-790052 | Rattus norvegicus (Norway rat) | IC50 | 29.2000 | 1 | 1 |
| N-[(5-bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 1.2695 | 3 | 3 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.1631 | 8 | 7 |
| olanzapine | Rattus norvegicus (Norway rat) | Ki | 0.5000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Kd | 5.4954 | 2 | 4 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Kd | 0.0025 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.0324 | 1 | 1 |
| pk 11195 | Rattus norvegicus (Norway rat) | Kd | 0.0020 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.3548 | 1 | 2 |
| ro 5-4864 | Rattus norvegicus (Norway rat) | Kd | 0.0580 | 1 | 1 |
| atenolol | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 1 | 2 |
| betaxolol | Rattus norvegicus (Norway rat) | Kd | 0.1047 | 1 | 2 |
| cirazoline | Rattus norvegicus (Norway rat) | EC50 | 0.0378 | 2 | 2 |
| clofazimine | Rattus norvegicus (Norway rat) | EC50 | 30.0000 | 1 | 0 |
| amphetamine | Rattus norvegicus (Norway rat) | Kd | 5.3703 | 3 | 5 |
| diazepam | Rattus norvegicus (Norway rat) | Kd | 0.2130 | 1 | 1 |
| medazepam | Rattus norvegicus (Norway rat) | Kd | 0.0100 | 1 | 1 |
| mescaline | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| metoprolol | Rattus norvegicus (Norway rat) | Kd | 0.1622 | 1 | 2 |
| naphazoline | Rattus norvegicus (Norway rat) | EC50 | 0.0631 | 1 | 1 |
| oxymetazoline | Rattus norvegicus (Norway rat) | EC50 | 12.5694 | 2 | 2 |
| o-methyltyramine | Rattus norvegicus (Norway rat) | Kd | 7.9433 | 1 | 2 |
| practolol | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| propranolol | Rattus norvegicus (Norway rat) | Kd | 0.0031 | 2 | 3 |
| sumatriptan | Rattus norvegicus (Norway rat) | EC50 | 1.3000 | 1 | 1 |
| tyramine | Rattus norvegicus (Norway rat) | Kd | 8.5114 | 1 | 2 |
| dextroamphetamine | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Kd | 1.0000 | 1 | 1 |
| dimethoxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 4.3652 | 1 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 3.5481 | 1 | 2 |
| 3-phenylpropylamine | Rattus norvegicus (Norway rat) | Kd | 11.7490 | 1 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0661 | 2 | 3 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.1549 | 2 | 3 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 7.0795 | 2 | 3 |
| l-amphetamine | Rattus norvegicus (Norway rat) | Kd | 6.9183 | 1 | 2 |
| timolol | Rattus norvegicus (Norway rat) | Kd | 0.0002 | 1 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Kd | 2.4547 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0447 | 2 | 3 |
| cathinone | Rattus norvegicus (Norway rat) | Kd | 3.0200 | 1 | 2 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.1479 | 2 | 3 |
| 9-methoxyellipticine | Rattus norvegicus (Norway rat) | EC50 | 30.0000 | 1 | 0 |
| methyl fluorone black | Rattus norvegicus (Norway rat) | EC50 | 4.0200 | 1 | 0 |
| 3,4-methylenedioxyphenethylamine | Rattus norvegicus (Norway rat) | Kd | 0.7943 | 1 | 2 |
| 3-methoxy-4-hydroxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 1.2882 | 1 | 2 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Kd | 0.1412 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0753 | 2 | 3 |
| (6ar-trans)-isomer of tetrahydrocannabivarin 9 | Rattus norvegicus (Norway rat) | EC50 | 0.0054 | 1 | 1 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Kd | 0.0851 | 1 | 1 |
| a 81988 | Rattus norvegicus (Norway rat) | Kd | 0.0001 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 3 | 4 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Kd | 2.8840 | 2 | 3 |
| Glyceryl lactopalmitate | Rattus norvegicus (Norway rat) | EC50 | 5.3200 | 1 | 0 |
| 5-(4-chlorophenyl)-N-[4-(4-methyl-1-piperazinyl)phenyl]-2-furancarboxamide | Rattus norvegicus (Norway rat) | EC50 | 2.2600 | 1 | 0 |
| 1H-benzimidazole-5,6-diamine | Rattus norvegicus (Norway rat) | EC50 | 10.7400 | 1 | 0 |
| pm 1000 | Rattus norvegicus (Norway rat) | EC50 | 0.0550 | 1 | 1 |
| N-[2-(2-methyl-1-indolyl)ethyl]benzamide | Rattus norvegicus (Norway rat) | EC50 | 3.0200 | 1 | 0 |
| 5-bromo-N-[2-(2-methyl-1-indolyl)ethyl]-2-furancarboxamide | Rattus norvegicus (Norway rat) | EC50 | 3.4800 | 1 | 0 |
| cp 135807 | Rattus norvegicus (Norway rat) | EC50 | 0.0470 | 1 | 1 |
| 3,3'-diethylthiatricarbocyanine iodide, 3h-labeled | Rattus norvegicus (Norway rat) | EC50 | 30.0000 | 1 | 0 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.0234 | 1 | 1 |
| methylhistaprodifen | Rattus norvegicus (Norway rat) | Kd | 14.4544 | 1 | 1 |
| histaprodifen | Rattus norvegicus (Norway rat) | Kd | 45.7088 | 1 | 1 |
| chlorhexidine hydrochloride | Rattus norvegicus (Norway rat) | EC50 | 0.6700 | 1 | 0 |
| 8-[1-(1,3-benzodioxol-5-yl)-3-(1-piperidinyl)propyl]-5,7-dimethoxy-4-pentyl-1-benzopyran-2-one | Rattus norvegicus (Norway rat) | EC50 | 30.0000 | 1 | 0 |
| 8-{1-[4-(dimethylamino)phenyl]-3-(pyrrolidin-1-yl)propyl}-5,7-dimethoxy-4-pentyl-2H-chromen-2-one | Rattus norvegicus (Norway rat) | EC50 | 20.9400 | 1 | 0 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.1175 | 1 | 1 |
| vu0357017 | Rattus norvegicus (Norway rat) | EC50 | 95.7200 | 1 | 0 |
Drugs with Other Measurements
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Synthesis and biological investigation of new equatorial (β) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation.European journal of medicinal chemistry, , Volume: 47, Issue:1, 2012
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.Bioorganic & medicinal chemistry, , Dec-15, Volume: 15, Issue:24, 2007
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.Journal of medicinal chemistry, , Jul-31, Volume: 46, Issue:16, 2003
Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.Journal of medicinal chemistry, , Dec-19, Volume: 45, Issue:26, 2002
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.Bioorganic & medicinal chemistry letters, , Mar-06, Volume: 10, Issue:5, 2000
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
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Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
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Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.Journal of medicinal chemistry, , Jun-25, Volume: 58, Issue:12, 2015
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1-aryl-4-[(5-methoxy-1,2,3, 4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5.Journal of medicinal chemistry, , Feb-11, Volume: 42, Issue:3, 1999
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Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
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Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues.Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995
New (2-methoxyphenyl)piperazine derivatives as 5-HT1A receptor ligands with reduced alpha 1-adrenergic activity. Synthesis and structure-affinity relationships.Journal of medicinal chemistry, , Apr-14, Volume: 38, Issue:8, 1995
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[no title available],
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
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Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
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[no title available],
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Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.Journal of medicinal chemistry, , Volume: 32, Issue:5, 1989
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
[no title available]European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.Journal of medicinal chemistry, , Dec-02, Volume: 42, Issue:24, 1999
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
New (2-methoxyphenyl)piperazine derivatives as 5-HT1A receptor ligands with reduced alpha 1-adrenergic activity. Synthesis and structure-affinity relationships.Journal of medicinal chemistry, , Apr-14, Volume: 38, Issue:8, 1995
N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites?Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.Bioorganic & medicinal chemistry letters, , Feb-25, Volume: 12, Issue:4, 2002
[no title available],
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
[no title available],
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
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New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties.Journal of medicinal chemistry, , Volume: 28, Issue:7, 1985
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
beta 1-selective adrenoceptor antagonists. 1. Synthesis and beta-adrenergic blocking activity of a series of binary (aryloxy)propanolamines.Journal of medicinal chemistry, , Volume: 26, Issue:11, 1983
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[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).Journal of medicinal chemistry, , Dec-31, Volume: 41, Issue:27, 1998
[no title available],
5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding.Journal of medicinal chemistry, , Dec-03, Volume: 41, Issue:25, 1998
Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.Journal of medicinal chemistry, , May-24, Volume: 39, Issue:11, 1996
Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.Journal of medicinal chemistry, , Jul-19, Volume: 39, Issue:15, 1996
Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonist N,N-dimethyltryptamine.Journal of medicinal chemistry, , Mar-25, Volume: 42, Issue:6, 1999
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.Journal of medicinal chemistry, , Oct-25, Volume: 39, Issue:22, 1996
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.Journal of medicinal chemistry, , Volume: 32, Issue:5, 1989
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
[no title available],
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 29, Issue:21, 2019
Indolebutylamines as selective 5-HT(1A) agonists.Journal of medicinal chemistry, , Sep-09, Volume: 47, Issue:19, 2004
Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues.Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.Journal of medicinal chemistry, , May-24, Volume: 39, Issue:11, 1996
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993
Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.European journal of medicinal chemistry, , Volume: 63, 2013
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods.Journal of medicinal chemistry, , Dec-10, Volume: 36, Issue:25, 1993
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors.Journal of medicinal chemistry, , Jun-25, Volume: 36, Issue:13, 1993
Synthesis and structure-activity relationships of 3,5-disubstituted 4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ones at diazepam-sensitive and diazepam-insensitive benzodiazepine receptors.Journal of medicinal chemistry, , Feb-19, Volume: 36, Issue:4, 1993
Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors.Bioorganic & medicinal chemistry letters, , Jun-07, Volume: 9, Issue:11, 1999
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.Journal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.Journal of medicinal chemistry, , Dec-02, Volume: 42, Issue:24, 1999
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods.Journal of medicinal chemistry, , Dec-10, Volume: 36, Issue:25, 1993
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
(R)-11-hydroxy- and (R)-11-hydroxy-10-methylaporphine: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.Journal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands.Journal of medicinal chemistry, , Volume: 34, Issue:6, 1991
(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacJournal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993
N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Advances in development of dopaminergic aporphinoids.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-19, Volume: 9, Issue:14, 1999
6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).Journal of medicinal chemistry, , Dec-31, Volume: 41, Issue:27, 1998
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.Journal of medicinal chemistry, , Jun-21, Volume: 39, Issue:13, 1996
Piperazinylalkyl heterocycles as potential antipsychotic agents.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
N-aryl-N'-benzylpiperazines as potential antipsychotic agents.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents.Journal of medicinal chemistry, , Aug-05, Volume: 37, Issue:16, 1994
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.Journal of medicinal chemistry, , Apr-15, Volume: 37, Issue:8, 1994
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
[no title available],