Page last updated: 2024-08-08 00:08:20

Solute carrier organic anion transporter family member 2A1

A solute carrier organic anion transporter family member 2A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92959]

Synonyms

Prostaglandin transporter;
PGT;
Solute carrier family 21 member 2

Research

Bioassay Publications (4)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (12)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
phosphoenolpyruvateHomo sapiens (human)Ki13,000.000011
pyruvic acidHomo sapiens (human)Ki26,000.000011
d-lactic acidHomo sapiens (human)Ki48,000.000011
glyceraldehyde 3-phosphateHomo sapiens (human)Ki15,000.000011
alpha-D-fructofuranose 1,6-bisphosphateHomo sapiens (human)Ki51,000.000011
prostaglandin d2Homo sapiens (human)Ki0.038011
dinoprostHomo sapiens (human)Ki0.023011
latanoprostHomo sapiens (human)Ki10.000011
phxa 85Homo sapiens (human)Ki0.149011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
prostaglandin d2Homo sapiens (human)K1/20.083011
dinoprostoneHomo sapiens (human)K1/20.100011
dinoprostHomo sapiens (human)K1/20.092011
alprostadilHomo sapiens (human)K1/20.082011
thromboxane b2Homo sapiens (human)K1/20.182011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
lipid transporter activitymolecular functionEnables the directed movement of lipids into, out of or within a cell, or between cells. [GOC:ai]
prostaglandin transmembrane transporter activitymolecular functionEnables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai]
sodium-independent organic anion transmembrane transporter activitymolecular functionEnables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
lysosomecellular componentA small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basal plasma membranecellular componentThe region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
basolateral plasma membranecellular componentThe region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
lipid transportbiological processThe directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [ISBN:0198506732]
sodium-independent organic anion transportbiological processThe directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]
transmembrane transportbiological processThe process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
prostaglandin transportbiological processThe directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]