Compounds > osw 1
Page last updated: 2024-11-07

osw 1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

OSW 1: RN given for the (3beta,16beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID132694
MeSH IDM0277282
PubMed CID9854230
CHEMBL ID375269
SCHEMBL ID17383554
MeSH IDM0277282

Synonyms (15)

Synonym
3,16,17-trihydroxycholest-5-en-22-one 16-o-(2-o-4-methoxybenzoylxylopyranosyl)-1-3-(2-o-acetylarabinopyranoside)
cholest-5-en-22-one, 16-((2-o-acetyl-3-o-(2-o-(4-methoxybenzoyl)-beta-d-xylopyranosyl)-alpha-l-arabinopyranosyl)oxy)-3,17-dihydroxy-, (3beta,16beta)-
osw 1
[(2s,3r,4s,5r)-2-[(2s,3r,4s,5s)-3-acetyloxy-2-[[(3r,8s,9r,10r,13s,14r,16r,17s)-3,17-dihydroxy-10,13-dimethyl-17-[(2s)-6-methyl-3-oxoheptan-2-yl]-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-16-yl]oxy]-5-hydroxyoxan-4-yl]oxy-4,5-dihydro
osw-1
CHEMBL375269
AC-30874
SCHEMBL17383554
CS-0020992
HY-101213
(3beta,16beta)-16-[[2-o-acetyl-3-o-[2-o-(4-methoxybenzoyl)-beta-d-xylopyranosyl]-alpha-l-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one
EX-A3363
MS-31621
[(2s,3r,4s,5r)-2-[(2s,3r,4s,5s)-3-acetyloxy-2-[[(3s,8r,9s,10r,13s,14s,16s,17s)-3,17-dihydroxy-10,13-dimethyl-17-[(2s)-6-methyl-3-oxoheptan-2-yl]-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-16-yl]oxy]-5-hydroxyoxan-4-yl]oxy-4,5-dihydro
AKOS040744793
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (121)

Assay IDTitleYearJournalArticle
AID358573Cytotoxicity against human HT-29 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358812Cytotoxicity against human SN12C cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590323Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring TFE3 nuclear translocation at 2 uM incubated for 4 hrs by immunofluorescence imaging analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID358824Cytotoxicity against human T47D cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358802Cytotoxicity against human OVCAR-3 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590324Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring increase in TFE3-mediated GM130 mRNA expression at 2 uM incubated for 12 hrs2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID292457Cytotoxicity against mouse NIH 3T3 cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID358574Cytotoxicity against human KM12 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358821Cytotoxicity against human MDA-MB-435 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358576Cytotoxicity against human SF268 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590336Induction of ER stress in human HeLa cells assessed as effect on P-eIF2alpha level at 1 uM incubated for 1 to 24 hrs by immunoblotting analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID358563Cytotoxicity against human HOP62 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358815Cytotoxicity against human PC3 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590326Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring upregulation of ARF4 mRNA expression at 2 uM incubated for 12 hrs2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID358559Cytotoxicity against human RPMI8266 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358578Cytotoxicity against human SF539 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358803Cytotoxicity against human OVCAR4 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358580Cytotoxicity against human SNB75 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358817Cytotoxicity against human MCF7 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID101570Inhibition of the necrosis induced by compound in breast cancer MCF-7 cell line2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358794Cytotoxicity against human MALME-3M cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358567Cytotoxicity against human NCI-H460 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590341Induction of ER stress in human HeLa cells assessed as effect on BiP mRNA level at 2 uM incubated for 1 1 hrs by qRT-PCR analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID358579Cytotoxicity against human SNB19 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358555Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358808Cytotoxicity against human A498 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358582Cytotoxicity against human LOXIMVI cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358822Cytotoxicity against human MDA-N cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID597080Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
AID358561Cytotoxicity against human A549 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358809Cytotoxicity against human ACHN cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358807Cytotoxicity against human 786-0 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590330Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring increase in TFE3-mediated GCP60 mRNA expression at 2 uM incubated for 12 hrs2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID358569Cytotoxicity against human COLO205 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590321Induction of OSBP localization in golgi apparatus of human HeLa cells assessed as induction of cytosolic OSBP aggregation into vesicular structures at Golgi at 0.5 uM by eYFP detection based time-lapse imaging2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID91603Cytotoxicity (growth inhibition) against endometrial cancer ishikawa cell line at 10E-7 mol/L after 24 hr2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358571Cytotoxicity against human HCT116 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358564Cytotoxicity against human HOP92 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358557Cytotoxicity against human K562 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID105447Cytotoxicity (growth inhibition) against breast cancer MDAMB-231 cell line at 10E-8 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358562Cytotoxicity against human EKVX cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID597085Cytotoxicity against human T98 cells assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
AID358811Cytotoxicity against human RXF393 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID597082Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
AID358819Cytotoxicity against human MDA-MB-231 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID101751Cytotoxicity (growth inhibition) against breast cancer MCF-7 cell line at 10E-6 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358556Cytotoxicity against human CCRF-CEM cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID101750Cytotoxicity (growth inhibition) against breast cancer MCF-7 cell line at 10E-5 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358795Cytotoxicity against human M14 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358575Cytotoxicity against human SW620 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358820Cytotoxicity against human Hs 578T cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358581Cytotoxicity against human U251 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358823Cytotoxicity against human BT549 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID292451Cytotoxicity against K562 cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID358796Cytotoxicity against human SK-MEL-2 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358577Cytotoxicity against human SF295 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358797Cytotoxicity against human SK-MEL-28 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358804Cytotoxicity against human OVCAR5 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID292455Cytotoxicity against HOS cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID1590334Induction of ER stress in human HeLa cells assessed as effect on pATF6(N) level at 1 uM incubated for 1 to 24 hrs by immunoblotting analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID292449Cytotoxicity against CEM cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID358814Cytotoxicity against human UO31 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID597083Cytotoxicity against human HOS cells assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
AID1590322Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring TFE3(S)/TFE3(L) dephosphorylation at 1 uM incubated for 2 hrs by Western blot analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID358810Cytotoxicity against human Caki1 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590335Induction of ER stress in human HeLa cells assessed as effect on pXBP1(S) level at 1 uM incubated for 1 to 24 hrs by immunoblotting analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID1590333Induction of ER stress in human HeLa cells assessed as effect on pATF6(P) level at 1 uM incubated for 1 to 24 hrs by immunoblotting analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID1590319Induction of OSBP localization in golgi apparatus of human HeLa cells assessed as increase in colocalization of 58K golgi protein at 0.5 uM incubated for 30 mins by immunofluorescence imaging method2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID1590339Induction of ER stress in human HeLa cells assessed as effect on CHOP level at 1 uM incubated for 1 to 24 hrs by immunoblotting analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID358560Cytotoxicity against human SR cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590328Growth inhibition of human NCI60 cells2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID1590320Induction of OSBP localization in golgi apparatus of human HeLa cells assessed as dispersion of GM130 in to cytosol at 2 uM incubated for 6 hrs by immunofluorescence microscopic method2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID91604Cytotoxicity (growth inhibition) against endometrial cancer ishikawa cell line at 10E-8 mol/L after 24 hr2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID597086Cytotoxicity against human HCT116 assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
AID358799Cytotoxicity against human UACC257 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358570Cytotoxicity against human HCC2998 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID91601Cytotoxicity (growth inhibition) against endometrial cancer ishikawa cell line at 10E-5 mol/L after 24 hr2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358813Cytotoxicity against human TK10 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358805Cytotoxicity against human OVCAR8 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358558Cytotoxicity against human MOLT4 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID101752Cytotoxicity (growth inhibition) against breast cancer MCF-7 cell line at 10E-7 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358568Cytotoxicity against human NCI-H522 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358816Cytotoxicity against human DU145 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID91605Cytotoxicity (growth inhibition) against endometrial cancer ishikawa cell line at 10E-9 mol/L after 24 hr2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358801Cytotoxicity against human IGROV1 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590325Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring downregulation of HSP47 mRNA expression at 2 uM incubated for 12 hrs2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID358806Cytotoxicity against human SKOV3 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358800Cytotoxicity against human UACC62 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590317Induction of OSBP localization in golgi apparatus of human HeLa cells assessed as increase in colocalization of 58K golgi protein at 5 nM incubated for 30 mins by immunofluorescence imaging method2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID91600Inhibition of the necrosis induced by compound in endometrial cancer ishikawa cell line after 24 hr2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358565Cytotoxicity against human NCI-H23 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID358572Cytotoxicity against human HCT15 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590331Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring increase in TFE3-mediated UAP1L1 mRNA expression at 2 uM incubated for 12 hrs2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID1590338Induction of ER stress in human HeLa cells assessed as effect on ATF4 level at 1 uM incubated for 1 to 24 hrs by immunoblotting analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID91602Cytotoxicity (growth inhibition) against endometrial cancer ishikawa cell line at 10E-6 mol/L after 24 hr2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID1129731Cytotoxicity against human NCI60 cells2014Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7
Fluorescent analog of OSW-1 and its cellular localization.
AID597081Cytotoxicity against human G361 cells assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
AID292452Cytotoxicity against ARN8 cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID292456Cytotoxicity against A549 cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID292454Cytotoxicity against HeLa cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID105448Cytotoxicity (growth inhibition) against breast cancer MDAMB-231 cell line at 10E-9 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID101754Cytotoxicity (growth inhibition) against breast cancer MCF-7 cell line at 10E-9 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID358566Cytotoxicity against human NCI-H322M cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID597084Cytotoxicity against human A549 cells assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
AID1590332Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring increase in TFE3-mediated SIAT4A mRNA expression at 2 uM incubated for 12 hrs2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID597079Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
AID358798Cytotoxicity against human SK-MEL-5 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.
AID1590327Inhibition of OSBP in human HeLa cells assessed as induction of golgi stress by measuring GASE transactivation at 1 uM incubated for 24 hrs by GASE-luciferase reporter gene assay2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID1590342Induction of ER stress in human HeLa cells assessed as effect on ERdj4 mRNA level at 2 uM incubated for 1 1 hrs by qRT-PCR analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID1590329Induction of OSBP localization in golgi apparatus of human HeLa cells assessed as dispersion of giantin in to cytosol at 2 uM incubated for 6 hrs by immunofluorescence microscopic method2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID1129732Cytotoxicity against human HeLa cells after 24 hrs by XTT assay2014Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7
Fluorescent analog of OSW-1 and its cellular localization.
AID105446Cytotoxicity (growth inhibition) against breast cancer MDAMB-231 cell line at 10E-7 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID105445Cytotoxicity (growth inhibition) against breast cancer MDAMB-231 cell line at 10E-6 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID101753Cytotoxicity (growth inhibition) against breast cancer MCF-7 cell line at 10E-8 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID292450Cytotoxicity against MCF7 cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID105443Inhibition of the necrosis induced by compound in breast cancer MDAMB-231 cell line2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID1590337Induction of ER stress in human HeLa cells assessed as effect on eIF2alpha level at 1 uM incubated for 1 to 24 hrs by immunoblotting analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID292453Cytotoxicity against human G361 cells after 72 hrs2007Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
New analogues of the potent cytotoxic saponin OSW-1.
AID105444Cytotoxicity (growth inhibition) against breast cancer MDAMB-231 cell line at 10E-5 mol/L2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Synthesis of analogues of a potent antitumor saponin OSW-1.
AID1590340Induction of ER stress in human HeLa cells assessed as effect on CHOP mRNA level at 2 uM incubated for 1 1 hrs by qRT-PCR analysis2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
AID597087Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (58)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (5.17)18.2507
2000's21 (36.21)29.6817
2010's26 (44.83)24.3611
2020's8 (13.79)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.72 (24.57)
Research Supply Index4.06 (2.92)
Research Growth Index5.14 (4.65)
Search Engine Demand Index37.86 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews2 (3.51%)6.00%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other55 (96.49%)84.16%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		2.1510
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.3110dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
thymidine
[no description available]		2.0310pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
dehydroepiandrosterone
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.		2.422017-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid		androgen;
human metabolite;
mouse metabolite
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.		2.110adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.		2.110adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
oleanolic acid
[no description available]		2.1510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
dicarbethoxydihydrocollidine
Dicarbethoxydihydrocollidine: 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester.. 3,5-diethoxycarbonyl-1,4-dihydrocollidine : A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.		2.1510dihydropyridine;
ethyl ester		hepatic steatosis inducing agent
glycyrrhizic acid
glycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.		2.1510enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin		EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		2.0210beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
itraconazole
Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.. itraconazole : An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.		2.6120aromatic ether;
conazole antifungal drug;
cyclic ketal;
dichlorobenzene;
dioxolane;
N-arylpiperazine;
triazole antifungal drug;
triazoles		EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
Hedgehog signaling pathway inhibitor;
P450 inhibitor
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		210D-glucopyranoseepitope;
mouse metabolite
fluorexon
fluorexon: structure		2.1510xanthene dyefluorochrome
25-hydroxycholesterol
[no description available]		2.061025-hydroxy steroid;
oxysterol		human metabolite
u 73343
U 73343: an inactive analog of U 73122		2.3110
soyasaponin bb
soyasaponin Bb: has activity against polycystic kidney disease; isolated from soybean; structure in first source. soyasaponin I : A triterpenoid saponin that is composed of soyasapogenol B having an alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucopyranosiduronic acid moiety attached at the 3-position via a glycosidic linkage.		2.1510carbohydrate acid derivative;
pentacyclic triterpenoid;
trisaccharide derivative;
triterpenoid saponin		sialyltransferase inhibitor
docetaxel anhydrous
Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.		2.4110secondary alpha-hydroxy ketone;
tetracyclic diterpenoid		antimalarial;
antineoplastic agent;
photosensitizing agent
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		2.4720biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.1510cyclodextrin
e-z cinnamic acid
trans-cinnamic acid : The E (trans) isomer of cinnamic acid. cinnamic acid : A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.		2.110cinnamic acidplant metabolite
thapsigargin
Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.		2.0810butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
glycosides
[no description available]		3.8930
stilbenes
trans-stilbene : The trans-isomer of stilbene.. Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.		2.0610stilbene
schweinfurthin a
schweinfurthin A: a geranyl stilbene from plant Macaranga schweinfurthii; structure in first source		2.0610
fludarabine
[no description available]		2.0210purine nucleoside
brefeldin a
[no description available]		2.610macrolide antibioticPenicillium metabolite
1,2-oleoylphosphatidylcholine
1,2-oleoylphosphatidylcholine: RN given refers to (Z,Z)-isomer. dioleoyl phosphatidylcholine : A phosphatidylcholine in which the phosphatidyl acyl groups are both oleoyl.		2.1510phosphatidylcholine(1+)
dimyristoylphosphatidylcholine
1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).		2.15101,2-diacyl-sn-glycero-3-phosphocholine;
phosphatidylcholine 28:0;
tetradecanoate ester		antigen;
mouse metabolite
1-palmitoyl-2-oleoylphosphatidylcholine
1-palmitoyl-2-oleoylphosphatidylcholine: RN given refers to (Z)-isomer		2.1510
beta-escin
[no description available]		7.02560
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.5220
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		2.52201,2-diacyl-sn-glycero-3-phosphocholine
calpain
Calpain: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.		2.0810
phosphatidylinositol 4-phosphate
phosphatidylinositol 4-phosphate : A phosphatidylinositol monophosphate carrying the phosphate group at the 4-position.		2.1510
glycolipids
[no description available]		2.0610
cyclosporine
Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).		2.0810
digitonin
digitonin : A spirostanyl glycoside that is digitogenin in which the 3-hydroxy group is substituted by a beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->3)]-beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranosyl group. It is a steroidal saponin isolated from the foxglove plant, Digitalis purpurea. It is used extensively as a mild non-ionic detergent for extracting proteins from membranes for structure and function studies.. Digitonin: A glycoside obtained from Digitalis purpurea; the aglycone is digitogenin which is bound to five sugars. Digitonin solubilizes lipids, especially in membranes and is used as a tool in cellular biochemistry, and reagent for precipitating cholesterol. It has no cardiac effects.		2.5920
ritterazine b
ritterazine B: ritterazine analog extracted from Ritterella tokioka, has been shown to be chemically similar to cephalostatin 1; structure in first source		2.0610
cephalostatin i
cephalostatin I: two steroid units are annulated to a 1,4-pyrazine ring; RN given for (3'R-(3'alpha(R*),4'alpha,4'abeta,6'balpha,8'abeta,11'aalpha,11'bbeta,13'alpha,13'aalpha,13'bbeta,14'beta,15'alpha(3*R*,5''S*),16'abeta,17'balpha,19'abeta,22'aalpha,22'bbeta,24'aR'*))-isomer; structure in first source		2.0610
daunorubicin
daunorubicin : A natural product found in Actinomadura roseola.. Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.		2.0310aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones		antineoplastic agent;
bacterial metabolite
etoposide
[no description available]		210beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
25-hydroxycholesterol
[no description available]		2.211025-hydroxy steroid;
oxysterol		human metabolite
methotrexate
[no description available]		210dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
ConditionIndicatedRelationship StrengthStudiesTrials
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available]		02.7220
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.		02.7220
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Metastase
[description not available]		02.2510
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.2510
Cancer of Prostate
[description not available]		02.4110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.4110
Cancer of Colon
[description not available]		02.1510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.1510
Extravascular Hemolysis
[description not available]		02.1510
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.1510
Hepatocellular Carcinoma
[description not available]		02.4920
Cancer of Liver
[description not available]		02.4920
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.4920
Liver Neoplasms
Tumors or cancer of the LIVER.		02.4920
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.0810
Benign Neoplasms
[description not available]		03.9140
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.9140
Leucocythaemia
[description not available]		02.0810
Germinoblastoma
[description not available]		02.0810
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		02.0810
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		02.0810
B-Cell Chronic Lymphocytic Leukemia
[description not available]		02.0210
Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.		02.0210
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9910
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		01.9910
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		0210