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Adenosine receptor A1
An adenosine receptor A1 that is encoded in the genome of guinea pig. [OMA:P47745, PRO:DNx]
Synonyms
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (78.57) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
Compounds (27)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 1,3-dipropyl-8-cyclopentylxanthine | Cavia porcellus (domestic guinea pig) | Ki | 0.0060 | 8 | 8 |
| 8-cyclopentyl-1,3-dimethylxanthine | Cavia porcellus (domestic guinea pig) | Ki | 0.0950 | 1 | 1 |
| 8-phenyltheophylline | Cavia porcellus (domestic guinea pig) | Ki | 1.6000 | 1 | 1 |
| theophylline | Cavia porcellus (domestic guinea pig) | Ki | 21.3333 | 6 | 6 |
| caffeine | Cavia porcellus (domestic guinea pig) | Ki | 100.0000 | 5 | 5 |
| cgs 15943 | Cavia porcellus (domestic guinea pig) | Ki | 0.0100 | 1 | 1 |
| furosemide | Cavia porcellus (domestic guinea pig) | Ki | 100.0000 | 1 | 1 |
| 8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine | Cavia porcellus (domestic guinea pig) | Ki | 0.0110 | 2 | 2 |
| rolofylline | Cavia porcellus (domestic guinea pig) | Ki | 0.0012 | 5 | 5 |
| n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide | Cavia porcellus (domestic guinea pig) | Ki | 0.1400 | 2 | 2 |
| cp 66713 | Cavia porcellus (domestic guinea pig) | Ki | 6.9000 | 1 | 1 |
| 8-(dicyclopropylmethyl)-1,3-dipropylxanthine | Cavia porcellus (domestic guinea pig) | Ki | 0.0030 | 6 | 6 |
| kfm 19 | Cavia porcellus (domestic guinea pig) | Ki | 0.0150 | 2 | 2 |
| 1,3-dipropylxanthine | Cavia porcellus (domestic guinea pig) | Ki | 1.2000 | 4 | 4 |
| n(6)-cyclopentyladenosine | Cavia porcellus (domestic guinea pig) | Ki | 0.0003 | 1 | 1 |
| fk 838 | Cavia porcellus (domestic guinea pig) | Ki | 0.0100 | 1 | 1 |
| fk 453 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0006 | 1 | 1 |
| kf 17837 | Cavia porcellus (domestic guinea pig) | Ki | 1.5000 | 2 | 2 |
Drugs with Activation Measurements
Drugs with Other Measurements
Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon.Journal of medicinal chemistry, , 11-25, Volume: 63, Issue:22, 2020
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.Journal of medicinal chemistry, , Sep-18, Volume: 35, Issue:19, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.Journal of medicinal chemistry, , Sep-18, Volume: 35, Issue:19, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.Journal of medicinal chemistry, , Sep-18, Volume: 35, Issue:19, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.Journal of medicinal chemistry, , Sep-18, Volume: 35, Issue:19, 1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.Journal of medicinal chemistry, , Volume: 34, Issue:4, 1991
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992