Potassium voltage-gated channel subfamily KQT member 4

A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P56696]

KQT-like 4;
Potassium channel subunit alpha KvLQT4;
Voltage-gated potassium channel subunit Kv7.4

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide	Homo sapiens (human)	IC50	54,954,100,000.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ezogabine	Homo sapiens (human)	EC50	3.9400	2	2
bms204352	Homo sapiens (human)	EC50	2.4000	1	1
N-(2,4,6-trimethylphenyl)-3-bicyclo[2.2.1]heptanecarboxamide	Homo sapiens (human)	EC50	1.6000	1	1
ica 27243	Homo sapiens (human)	EC50	10.0000	1	1
(r)-n-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide	Homo sapiens (human)	EC50	30.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
flupirtine	Homo sapiens (human)	EC2	4.5600	2	2

This protein enables 3 target(s):

Target	Category	Definition
potassium channel activity	molecular function	Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
voltage-gated potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basal plasma membrane	cellular component	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated potassium channel complex	cellular component	A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]

This protein is involved in 4 target(s):

Target	Category	Definition
potassium ion transport	biological process	The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
sensory perception of sound	biological process	The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. [GOC:ai]
inner ear morphogenesis	biological process	The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. [GOC:jl, ISBN:0192801023]
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]