Proteins > NADH-ubiquinone oxidoreductase chain 4
Page last updated: 2024-08-07 15:35:50

NADH-ubiquinone oxidoreductase chain 4

An NADH-ubiquinone oxidoreductase chain 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P03905]

Synonyms

EC 7.1.1.2;
NADH dehydrogenase subunit 4

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Compounds (3)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
auraptenHomo sapiens (human)IC5014.500022
marminHomo sapiens (human)IC5030.000022

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
daunorubicinHomo sapiens (human)IC102.000011

Enables

This protein enables 2 target(s):

TargetCategoryDefinition
NADH dehydrogenase (ubiquinone) activitymolecular functionCatalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). [RHEA:29091]
ubiquinone bindingmolecular functionBinding to ubiquinone, a quinone derivative with a tail of isoprene units. [GOC:jid, ISBN:0582227089]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
mitochondrial inner membranecellular componentThe inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
mitochondrial respiratory chain complex Icellular componentA protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. [GOC:mtg_sensu, ISBN:0198547684]

Involved In

This protein is involved in 10 target(s):

TargetCategoryDefinition
response to hypoxiabiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
in utero embryonic developmentbiological processThe process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
mitochondrial electron transport, NADH to ubiquinonebiological processThe transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. [ISBN:0716731363]
aerobic respirationbiological processThe enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590]
cerebellum developmentbiological processThe process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
mitochondrial respiratory chain complex I assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. [GOC:rph]
response to nicotinebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
proton motive force-driven mitochondrial ATP synthesisbiological processThe transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. [GOC:mtg_sensu, ISBN:0716731363]
response to ethanolbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]
electron transport coupled proton transportbiological processThe transport of protons against an electrochemical gradient, using energy from electron transport. [GOC:mah]