Page last updated: 2024-08-07 13:38:22
Dihydrofolate reductase
[no definition available]
Synonyms
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| quetiapine | Bacillus anthracis | IC50 | 102.0000 | 1 | 1 |
| trimethoprim | Bacillus anthracis | IC50 | 45.7880 | 5 | 5 |
| trimethoprim | Bacillus anthracis | Ki | 12.7600 | 3 | 3 |
| methotrexate | Bacillus anthracis | IC50 | 0.0136 | 1 | 2 |
Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationships.Journal of medicinal chemistry, , Oct-28, Volume: 53, Issue:20, 2010
Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:7, 2009
Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase.Journal of medicinal chemistry, , Dec-11, Volume: 51, Issue:23, 2008