A phosphatidylcholine:ceramide cholinephosphotransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86VZ5]
EC 2.7.8.27;
Medulla oblongata-derived protein;
Protein Mob;
Sphingomyelin synthase 1;
Transmembrane protein 23
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| malabaricone c | Homo sapiens (human) | IC50 | 2.5000 | 2 | 2 |
| malabaricone b | Homo sapiens (human) | IC50 | 2.7500 | 2 | 2 |
| malabaricone a | Homo sapiens (human) | IC50 | 3.0000 | 2 | 2 |
| ginkgolic acid | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| ceramide phosphoethanolamine synthase activity | molecular function | Catalysis of the reaction: an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H+. [EC:2.7.8.48, PMID:25667419] |
| kinase activity | molecular function | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732] |
| sphingomyelin synthase activity | molecular function | Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. [EC:2.7.8.27, RHEA:18765] |
| ceramide cholinephosphotransferase activity | molecular function | Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin. [EC:2.7.8.3, RHEA:16273] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi trans cisterna | cellular component | The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. [ISBN:0815316194] |
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| sphingomyelin biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732] |
| apoptotic process | biological process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] |
| sphingolipid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732] |
| regulation of intrinsic apoptotic signaling pathway | biological process | Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis] |
| ceramide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. [GOC:ai] |