E3 ubiquitin-protein ligase XIAP

A baculoviral IAP repeat-containing protein 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P98170]

Synonyms

EC 2.3.2.27;
Baculoviral IAP repeat-containing protein 4;
IAP-like protein;
ILP;
hILP;
Inhibitor of apoptosis protein 3;
IAP-3;
hIAP-3;
hIAP3;
RING-type E3 ubiquitin transferase XIAP;
X-linked inhibitor of apoptosi

Research

Bioassay Publications (25)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (8.00)	29.6817
2010's	22 (88.00)	24.3611
2020's	1 (4.00)	2.80

Compounds (12)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
embelin	Homo sapiens (human)	IC50	4.1000	3	3
embelin	Homo sapiens (human)	Ki	0.4000	1	1
phenylalanine	Homo sapiens (human)	IC50	80.2000	1	1
kaempferol	Homo sapiens (human)	IC50	100.0000	1	1
kaempferol 3-o-rhamnoside	Homo sapiens (human)	IC50	100.0000	1	1
lbw242	Homo sapiens (human)	IC50	0.6400	2	2
sm 164	Homo sapiens (human)	IC50	0.0605	6	6
sm 164	Homo sapiens (human)	Ki	0.0235	4	4
lcl161	Homo sapiens (human)	IC50	0.2238	11	11
at 406	Homo sapiens (human)	IC50	0.1049	3	3
at 406	Homo sapiens (human)	Ki	0.0664	1	1
gdc-0152	Homo sapiens (human)	IC50	0.0316	3	3
gdc-0152	Homo sapiens (human)	Ki	7.5500	4	4
nvp-cgm097	Homo sapiens (human)	IC50	50.0000	1	1
2-carboxyarabinitol 1-phosphate	Homo sapiens (human)	IC50	10.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lbw242	Homo sapiens (human)	Kd	0.9000	1	1
sm 164	Homo sapiens (human)	EC50	0.2575	2	2
lcl161	Homo sapiens (human)	EC50	0.1590	2	2
lcl161	Homo sapiens (human)	Kd	0.0527	1	1
at 406	Homo sapiens (human)	EC50	0.0340	1	1
gdc-0152	Homo sapiens (human)	Kd	0.0760	3	3
birinapant	Homo sapiens (human)	Kd	0.0500	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
ubiquitin-protein transferase activity	molecular function	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. [GOC:BioGRID, GOC:jh2, PMID:9635407]
cysteine-type endopeptidase inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. [GOC:dph, GOC:tb]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	molecular function	Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
endopeptidase regulator activity	molecular function	Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. [GOC:dph, GOC:tb]
ubiquitin protein ligase activity	molecular function	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]
protein serine/threonine kinase binding	molecular function	Binding to a protein serine/threonine kinase. [GOC:krc, GOC:sl, PMID:28608965]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 25 target(s):

Target	Category	Definition
DNA damage response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
negative regulation of tumor necrosis factor-mediated signaling pathway	biological process	Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb]
Wnt signaling pathway	biological process	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397]
regulation of BMP signaling pathway	biological process	Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. [GOC:mah]
positive regulation of protein ubiquitination	biological process	Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]
positive regulation of type I interferon production	biological process	Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:mah]
regulation of cell population proliferation	biological process	Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
defense response to bacterium	biological process	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of canonical NF-kappaB signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
regulation of innate immune response	biological process	Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc]
positive regulation of JNK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
regulation of inflammatory response	biological process	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai]
neuron apoptotic process	biological process	Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis]
copper ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]
regulation of apoptosis involved in tissue homeostasis	biological process	Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. [GOC:dph]
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological process	Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway. [GOC:add]
nucleotide-binding oligomerization domain containing 1 signaling pathway	biological process	The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process. [GOC:add, PMID:17944960, PMID:18585455]
nucleotide-binding oligomerization domain containing 2 signaling pathway	biological process	The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process. [GOC:add, PMID:17944960, PMID:18585455]
protein K63-linked ubiquitination	biological process	A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. [GOC:mah, PMID:15556404]
positive regulation of canonical Wnt signaling pathway	biological process	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]
inhibition of cysteine-type endopeptidase activity	biological process	Any process that prevents the activation of an inactive cysteine-type endopeptidase. [GOC:mtg_apoptosis, PMID:20383739]
positive regulation of protein linear polyubiquitination	biological process	Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination. [GOC:TermGenie, PMID:21931591]
regulation of cell cycle	biological process	Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]