Interleukin-2

An interleukin-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P60568]

Synonyms

IL-2;
T-cell growth factor;
TCGF

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	1 (33.33)	24.3611
2020's	1 (33.33)	2.80

Compounds (7)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide	Homo sapiens (human)	Ki	0.0600	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
daidzin	Homo sapiens (human)	Kd	3.3800	1	1
ononin	Homo sapiens (human)	Kd	0.1200	1	1
formononetin	Homo sapiens (human)	Kd	5.4700	1	1
luteolin-7-glucoside	Homo sapiens (human)	Kd	0.0200	1	1
N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide	Homo sapiens (human)	Kd	0.1000	1	1
calycosin-7-o-beta-d-glucopyranoside	Homo sapiens (human)	Kd	0.0356	1	1
diosgenin glucoside	Homo sapiens (human)	Kd	0.0000	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
cytokine activity	molecular function	The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]
interleukin-2 receptor binding	molecular function	Binding to an interleukin-2 receptor. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
growth factor activity	molecular function	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]
kinase activator activity	molecular function	Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]
carbohydrate binding	molecular function	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]
kappa-type opioid receptor binding	molecular function	Binding to a kappa-type opioid receptor. [GOC:mah, GOC:nln]
glycosphingolipid binding	molecular function	Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:jl]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 33 target(s):

Target	Category	Definition
negative regulation of protein phosphorylation	biological process	Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
adaptive immune response	biological process	An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
leukocyte activation involved in immune response	biological process	A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]
transcription by RNA polymerase II	biological process	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
protein kinase C-activating G protein-coupled receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). [GOC:mah, GOC:signaling]
cell-cell signaling	biological process	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
natural killer cell activation	biological process	The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]
T cell differentiation	biological process	The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. [GO_REF:0000022, GOC:jid, GOC:mah]
positive regulation of cell growth	biological process	Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
positive regulation of type II interferon production	biological process	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
positive regulation of interleukin-17 production	biological process	Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511]
positive regulation of tissue remodeling	biological process	Any process that activates or increases the frequency, rate, or extent of tissue remodeling. [GOC:add]
interleukin-2-mediated signaling pathway	biological process	The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]
positive regulation of tyrosine phosphorylation of STAT protein	biological process	Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
response to ethanol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]
positive regulation of regulatory T cell differentiation	biological process	Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. [ISBN:0781735149]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
regulation of T cell homeostatic proliferation	biological process	Any process that modulates the frequency, rate or extent of resting T cell proliferation. [GOC:go_curators]
positive regulation of isotype switching to IgG isotypes	biological process	Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes. [GOC:jid]
negative regulation of lymphocyte proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. [GOC:ai]
negative regulation of inflammatory response	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]
positive regulation of inflammatory response	biological process	Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]
activated T cell proliferation	biological process	The expansion of a T cell population following activation by an antigenic stimulus. [GOC:add, GOC:dph]
positive regulation of dendritic spine development	biological process	Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. [GOC:dph]
extrinsic apoptotic signaling pathway in absence of ligand	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]
response to tacrolimus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus. [GOC:TermGenie]
negative regulation of T-helper 17 cell differentiation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation. [GOC:BHF, GOC:mah]
regulation of CD4-positive, alpha-beta T cell proliferation	biological process	Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol]