Proteins > Sodium/potassium-transporting ATPase subunit beta-3
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Sodium/potassium-transporting ATPase subunit beta-3
A sodium/potassium-transporting ATPase subunit beta-3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P54709]
Synonyms
Sodium/potassium-dependent ATPase subunit beta-3;
ATPB-3
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ouabain | Homo sapiens (human) | LC50 | 9.4000 | 1 | 1 |
Gombamide A, a cyclic thiopeptide from the sponge Clathria gombawuiensis.Journal of natural products, , Jul-26, Volume: 76, Issue:7, 2013
Sesterterpenes from the tropical sponge Coscinoderma sp.Journal of natural products, , Aug-26, Volume: 74, Issue:8, 2011
Synthesis and evaluation of panaxatriol derivatives as NaBioorganic & medicinal chemistry letters, , 09-15, Volume: 28, Issue:17, 2018
Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.Journal of medicinal chemistry, , Aug-14, Volume: 46, Issue:17, 2003
Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.Journal of medicinal chemistry, , Aug-14, Volume: 46, Issue:17, 2003
Synthesis and inotropic activity of 1-(O-aminoalkyloximes) of perhydroindene derivatives as simplified digitalis-like compounds acting on the Na(+),K(+)-ATPase.Journal of medicinal chemistry, , Jan-03, Volume: 45, Issue:1, 2002
17 alpha-O-(aminoalkyl)oxime derivatives of 3 beta,14 beta-dihydroxy-5 beta-androstane and 3 beta-hydroxy-14-oxoseco-D-5 beta-androstane as inhibitors of Na(+),K(+)-ATPase at the digitalis receptor.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor-5 beta,14 beta-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor.Journal of medicinal chemistry, , Jan-08, Volume: 36, Issue:1, 1993
Cardiac glycosides. 7. Sugar stereochemistry and cardiac glycoside activity.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| ATPase activator activity | molecular function | Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein-macromolecule adaptor activity | molecular function | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw] |
| ATPase binding | molecular function | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai] |
Located In
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| sperm flagellum | cellular component | A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. [GOC:cilia, GOC:sart, PMID:8441407] |
| melanosome | cellular component | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| sodium:potassium-exchanging ATPase complex | cellular component | Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732] |
Involved In
This protein is involved in 13 target(s):
| Target | Category | Definition |
|---|
| intracellular sodium ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah] |
| intracellular potassium ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah] |
| positive regulation of ATP-dependent activity | biological process | Any process that activates or increases the rate of an ATP-dependent activity. [GOC:mah] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |
| sodium ion export across plasma membrane | biological process | The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689] |
| protein stabilization | biological process | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai] |
| potassium ion transmembrane transport | biological process | A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah] |
| protein localization to plasma membrane | biological process | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah] |
| membrane repolarization | biological process | The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| positive regulation of potassium ion transmembrane transporter activity | biological process | Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie] |
| positive regulation of sodium ion export across plasma membrane | biological process | Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] |
| positive regulation of potassium ion import across plasma membrane | biological process | Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] |
| potassium ion import across plasma membrane | biological process | The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127] |