C-C chemokine receptor type 1

A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246]

Synonyms

C-C CKR-1;
CC-CKR-1;
CCR-1;
CCR1;
HM145;
LD78 receptor;
Macrophage inflammatory protein 1-alpha receptor;
MIP-1alpha-R;
RANTES-R

Research

Bioassay Publications (13)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (7.69)	18.2507
2000's	8 (61.54)	29.6817
2010's	4 (30.77)	24.3611
2020's	0 (0.00)	2.80

Compounds (16)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1,10-phenanthroline	Homo sapiens (human)	IC50	76.7164	1	2
2,2'-dipyridyl	Homo sapiens (human)	IC50	125.9465	1	2
4,4'-dimethyl-2,2'-bipyridine	Homo sapiens (human)	IC50	100.5000	1	2
5,5'-dimethyl-2,2'-bipyridyl	Homo sapiens (human)	IC50	201.7630	1	2
neocuproine	Homo sapiens (human)	IC50	1,000.0000	1	2
5-methyl-1,10-phenanthroline	Homo sapiens (human)	IC50	122.4465	1	2
3,4,7,8-tetramethyl-1,10-phenanthroline	Homo sapiens (human)	IC50	164.7445	1	2
tak 779	Homo sapiens (human)	IC50	10.0000	1	1
bx 471	Homo sapiens (human)	IC50	0.0109	7	7
bx 471	Homo sapiens (human)	Ki	0.0010	1	1
cp 481715	Homo sapiens (human)	IC50	0.0490	2	2
cp 481715	Homo sapiens (human)	Ki	0.0740	1	1
ucb 35625	Homo sapiens (human)	IC50	0.0101	3	5
vuf 2274	Homo sapiens (human)	IC50	1.0593	3	3
vuf 2274	Homo sapiens (human)	Ki	0.0520	1	1
amd 070	Homo sapiens (human)	IC50	10.0000	1	1
a 803467	Homo sapiens (human)	IC50	10.0000	1	1
raltegravir	Homo sapiens (human)	Ki	0.0050	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1,10-phenanthroline	Homo sapiens (human)	EC50	6.1048	1	2
2,2'-dipyridyl	Homo sapiens (human)	EC50	32.8114	1	2
4,4'-dimethyl-2,2'-bipyridine	Homo sapiens (human)	EC50	3.7905	1	2
5,5'-dimethyl-2,2'-bipyridyl	Homo sapiens (human)	EC50	16.4244	1	2
neocuproine	Homo sapiens (human)	EC50	1.5924	1	2
2,2',2''-terpyridine	Homo sapiens (human)	EC50	63.5478	1	2
5-methyl-1,10-phenanthroline	Homo sapiens (human)	EC50	1.8976	1	2
3,4,7,8-tetramethyl-1,10-phenanthroline	Homo sapiens (human)	EC50	1.5424	1	2
bx 471	Homo sapiens (human)	Kd	0.0010	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
phosphatidylinositol phospholipase C activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+. [EC:3.1.4.11, RHEA:33179]
chemokine receptor activity	molecular function	Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, GOC:signaling, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823, Wikipedia:Chemokine]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
C-C chemokine receptor activity	molecular function	Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:signaling, PMID:8662823]
C-C chemokine binding	molecular function	Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]
chemokine (C-C motif) ligand 7 binding	molecular function	Binding to chemokine (C-C motif) ligand 7. [GOC:BHF]
chemokine (C-C motif) ligand 5 binding	molecular function	Binding to chemokine (C-C motif) ligand 5. [GOC:add, GOC:amm]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 25 target(s):

Target	Category	Definition
dendritic cell chemotaxis	biological process	The movement of a dendritic cell in response to an external stimulus. [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
monocyte chemotaxis	biological process	The movement of a monocyte in response to an external stimulus. [GOC:add, PMID:11696603, PMID:15173832]
calcium ion transport	biological process	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
intracellular calcium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]
exocytosis	biological process	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. [GOC:mah, ISBN:0716731363, PMID:22323285]
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
cell-cell signaling	biological process	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
response to wounding	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. [GOC:go_curators]
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
cytokine-mediated signaling pathway	biological process	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
negative regulation of bone mineralization	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. [GOC:go_curators]
positive regulation of osteoclast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]
positive regulation of calcium ion transport	biological process	Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
chemokine-mediated signaling pathway	biological process	The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
positive regulation of monocyte chemotaxis	biological process	Any process that increases the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]
calcium-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
cell chemotaxis	biological process	The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]