Page last updated: 2024-08-07 15:59:04
Substance-P receptor
A substance-P receptor that is encoded in the genome of rat. [OMA:P14600, PRO:DNx]
Synonyms
SPR;
NK-1 receptor;
NK-1R;
Tachykinin receptor 1
Research
Bioassay Publications (16)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cp 96345 | Rattus norvegicus (Norway rat) | Kd | 0.0003 | 1 | 1 |
Conformational comparisons of a series of tachykinin peptide analogs.Journal of medicinal chemistry, , Dec-27, Volume: 50, Issue:26, 2007
Design, synthesis, and evaluation of Phe-Gly mimetics: heterocyclic building blocks for pseudopeptides.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists.Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.Journal of medicinal chemistry, , Aug-27, Volume: 52, Issue:16, 2009
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.Journal of medicinal chemistry, , Oct-23, Volume: 51, Issue:20, 2008
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.Journal of medicinal chemistry, , Mar-13, Volume: 51, Issue:5, 2008
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.Journal of medicinal chemistry, , Jun-14, Volume: 50, Issue:12, 2007
Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.Journal of medicinal chemistry, , Apr-29, Volume: 37, Issue:9, 1994
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.Journal of medicinal chemistry, , Mar-13, Volume: 51, Issue:5, 2008
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.Journal of medicinal chemistry, , Jun-14, Volume: 50, Issue:12, 2007