Page last updated: 2024-08-07 13:25:20

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

A serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform that is encoded in the genome of human. [PRO:CNA, UniProtKB:P63151]

Synonyms

PP2A subunit B isoform B55-alpha;
PP2A subunit B isoform PR55-alpha;
PP2A subunit B isoform R2-alpha;
PP2A subunit B isoform alpha

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
cyanoginosin lrHomo sapiens (human)IC500.000111

Enables

This protein enables 2 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
protein phosphatase regulator activitymolecular functionBinds to and modulates the activity of a protein phosphatase. [GOC:ai]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
glutamatergic synapsecellular componentA synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
protein phosphatase type 2A complexcellular componentA protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. [GOC:mah, ISBN:0198547684, PMID:17245430]

Involved In

This protein is involved in 2 target(s):

TargetCategoryDefinition
protein dephosphorylationbiological processThe process of removing one or more phosphoric residues from a protein. [GOC:hb]
response to morphinebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. [GOC:ef, GOC:jl]