A 10 kDa heat shock protein, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61604]
Hsp10;
10 kDa chaperonin;
Chaperonin 10;
CPN10;
Early-pregnancy factor;
EPF
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-nonylphenol | Homo sapiens (human) | IC50 | 9.5000 | 1 | 1 |
| albuterol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| aurintricarboxylic acid | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| benzbromarone | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| bithionol | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| candesartan | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| eflornithine | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| dichlorophen | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| ethacrynic acid | Homo sapiens (human) | IC50 | 8.5000 | 1 | 1 |
| harmalol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| hexachlorophene | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| beta-lapachone | Homo sapiens (human) | IC50 | 2.1000 | 1 | 1 |
| vitamin k 3 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| mesalamine | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| pentamidine | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| primaquine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| protoporphyrin ix | Homo sapiens (human) | IC50 | 4.9000 | 1 | 1 |
| cetrimonium bromide | Homo sapiens (human) | IC50 | 7.4000 | 1 | 1 |
| ampicillin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| purpurin | Homo sapiens (human) | IC50 | 23.0000 | 1 | 1 |
| salicylanilide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| benzanilide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| benzethonium chloride | Homo sapiens (human) | IC50 | 23.0000 | 1 | 1 |
| evans blue | Homo sapiens (human) | IC50 | 0.1700 | 1 | 1 |
| lithocholic acid | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| plumbagin | Homo sapiens (human) | IC50 | 6.3000 | 1 | 1 |
| gentian violet | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| erythromycin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| agaric acid | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| ethidium bromide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| vancomycin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cetylpyridinium chloride | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| rafoxanide | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| paclitaxel | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| closantel | Homo sapiens (human) | IC50 | 2.6500 | 2 | 2 |
| adapalene | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| sb 204070a | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| gossypol acetic acid | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| tretinoin | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| arachidonic acid | Homo sapiens (human) | IC50 | 4.5000 | 1 | 1 |
| riboflavin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4'-methoxychalcone | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| 4-chloro-3-nitro-1-(phenylmethyl)-2-quinolinone | Homo sapiens (human) | IC50 | 126.4000 | 2 | 2 |
| curcumin | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| gossypetin | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
| vitamin d 2 | Homo sapiens (human) | IC50 | 45.0000 | 1 | 1 |
| cholecalciferol | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| morin | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| 4-hydroxychalcone | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| 4'-hydroxychalcone | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| phenoxybenzamine hydrochloride | Homo sapiens (human) | IC50 | 78.0000 | 1 | 1 |
| nalbuphine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 22,23-dihydroavermectin b(1)a | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| avermectin b(1)a | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| nifurtimox | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| erythrosine | Homo sapiens (human) | IC50 | 2.9000 | 1 | 1 |
| tannins | Homo sapiens (human) | IC50 | 3.8000 | 1 | 1 |
| ly-146032 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 6-o-palmitoylascorbic acid | Homo sapiens (human) | IC50 | 3.1000 | 1 | 1 |
| rifampin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| hematein | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| protein folding chaperone | molecular function | Binding to a protein or a protein-containing complex to assist the protein folding process. [GOC:mtg_cambridge_2009] |
| unfolded protein binding | molecular function | Binding to an unfolded protein. [GOC:ai] |
| protein-folding chaperone binding | molecular function | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| osteoblast differentiation | biological process | The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid] |
| protein folding | biological process | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb] |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | biological process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] |
| response to unfolded protein | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. [GOC:jl] |
| chaperone cofactor-dependent protein refolding | biological process | The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. [GOC:rb] |