Amiloride-sensitive amine oxidase [copper-containing]

An amiloride-sensitive amine oxidase [copper-containing] that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19801]

Synonyms

DAO;
Diamine oxidase;
EC 1.4.3.22;
Amiloride-binding protein 1;
Amine oxidase copper domain-containing protein 1;
Histaminase;
Kidney amine oxidase;
KAO

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
diminazene	Homo sapiens (human)	Ki	0.0130	1	1
pentamidine	Homo sapiens (human)	Ki	0.2900	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzylamine	Homo sapiens (human)	Km	557.0000	1	1

Enables

This protein enables 12 target(s):

Target	Category	Definition
copper ion binding	molecular function	Binding to a copper (Cu) ion. [GOC:ai]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
primary amine oxidase activity	molecular function	Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. [EC:1.4.3.21]
heparin binding	molecular function	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
quinone binding	molecular function	Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. [ISBN:0198506732]
putrescine oxidase activity	molecular function	Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2. [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN]
diamine oxidase activity	molecular function	Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide. [MetaCyc:RXN-9599]
histamine oxidase activity	molecular function	Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+. [MetaCyc:RXN-9600]
methylputrescine oxidase activity	molecular function	Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+. [MetaCyc:RXN-8244, PMID:17283012, PMID:24287136]
propane-1,3-diamine oxidase activity	molecular function	Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+. [MetaCyc:RXN-6381]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
peroxisome	cellular component	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
bicellular tight junction	cellular component	An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. [GOC:mah, ISBN:0815332181]
specific granule lumen	cellular component	The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 3 target(s):

Target	Category	Definition
putrescine metabolic process	biological process	The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine. [GOC:ai]
response to antibiotic	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. [GOC:ai, GOC:ef]
amine metabolic process	biological process	The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]