A CDGSH iron-sulfur domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZ45]
MitoNEET
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-amino-1,8-naphthalimide | Homo sapiens (human) | IC50 | 264.0000 | 1 | 1 |
| 4-amino-1,8-naphthalimide | Homo sapiens (human) | Ki | 11.2820 | 1 | 1 |
| tyrphostin ag 1024 | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| tyrphostin ag 1024 | Homo sapiens (human) | Ki | 0.0770 | 1 | 1 |
| carbonyl cyanide m-chlorophenyl hydrazone | Homo sapiens (human) | IC50 | 35.0400 | 1 | 1 |
| carbonyl cyanide m-chlorophenyl hydrazone | Homo sapiens (human) | Ki | 1.4970 | 1 | 1 |
| furosemide | Homo sapiens (human) | IC50 | 53.4600 | 1 | 1 |
| furosemide | Homo sapiens (human) | Ki | 2.2850 | 1 | 1 |
| gemfibrozil | Homo sapiens (human) | IC50 | 170.6000 | 1 | 1 |
| gemfibrozil | Homo sapiens (human) | Ki | 7.2910 | 1 | 1 |
| glyburide | Homo sapiens (human) | IC50 | 39.1000 | 1 | 1 |
| glyburide | Homo sapiens (human) | Ki | 1.6710 | 1 | 1 |
| pioglitazone | Homo sapiens (human) | IC50 | 8.6500 | 1 | 1 |
| pioglitazone | Homo sapiens (human) | Ki | 0.3700 | 1 | 1 |
| ursodeoxycholic acid | Homo sapiens (human) | IC50 | 26.5400 | 1 | 1 |
| ursodeoxycholic acid | Homo sapiens (human) | Ki | 1.1340 | 1 | 1 |
| rosiglitazone | Homo sapiens (human) | IC50 | 0.7310 | 1 | 1 |
| rosiglitazone | Homo sapiens (human) | Ki | 0.0310 | 1 | 1 |
| tyrphostin 8 | Homo sapiens (human) | IC50 | 1.8290 | 1 | 1 |
| tyrphostin 8 | Homo sapiens (human) | Ki | 0.0780 | 1 | 1 |
| curcumin | Homo sapiens (human) | IC50 | 2.3600 | 1 | 1 |
| curcumin | Homo sapiens (human) | Ki | 0.1010 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 3.1000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | Ki | 0.1320 | 1 | 1 |
| as 605240 | Homo sapiens (human) | IC50 | 3.2600 | 1 | 1 |
| nitrofurantoin | Homo sapiens (human) | IC50 | 19.1000 | 1 | 1 |
| nitrofurantoin | Homo sapiens (human) | Ki | 0.8160 | 1 | 1 |
| dantrolene | Homo sapiens (human) | IC50 | 48.3300 | 1 | 1 |
| dantrolene | Homo sapiens (human) | Ki | 2.0650 | 1 | 1 |
| 3-aminopyridine-2-carboxaldehyde thiosemicarbazone | Homo sapiens (human) | IC50 | 9.0780 | 1 | 1 |
| 3-aminopyridine-2-carboxaldehyde thiosemicarbazone | Homo sapiens (human) | Ki | 0.3880 | 1 | 1 |
| tryprostatin a | Homo sapiens (human) | IC50 | 3.3870 | 1 | 1 |
| tryprostatin a | Homo sapiens (human) | Ki | 0.1450 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| pyridoxal phosphate binding | molecular function | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| L-cysteine transaminase activity | molecular function | Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate. [RHEA:17441] |
| 2 iron, 2 sulfur cluster binding | molecular function | Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| regulation of autophagy | biological process | Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb] |
| regulation of cellular respiration | biological process | Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. [GOC:jl] |
| protein maturation by [2Fe-2S] cluster transfer | biological process | The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. [PMID:23615440] |