isoflurane has been researched along with Necrosis in 35 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups." | 7.85 | Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats. ( Carvalho, LR; Castiglia, YM; Deffune, E; Golim, MA; Lemos, SV; Módolo, NS; Nascimento, PD; Souza, AV; Vianna, IG; Vianna, PT, 2017) |
| "The volatile anesthetic isoflurane protects against renal ischemia and reperfusion injury by releasing renal tubular TGF-β1." | 7.79 | The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury. ( Brown, KM; D'Agati, VD; Ham, A; Kim, JY; Kim, M; Lee, HT, 2013) |
| "To evaluate the effect of N-acetylcysteine, as a renoprotective agent, when administered early after anesthesia induction, against ischemia/reperfusion injury in rats anesthetized with isoflurane." | 7.78 | Prevention of renal ischemia/reperfusion injury in rats using acetylcysteine after anesthesia with isoflurane. ( Braz, LG; Castiglia, YM; Fabris, VE; Mansano, AM; Silva, LM; Vianna, PT, 2012) |
| " We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane." | 7.69 | Fatal hepatic necrosis after isoflurane anaesthesia. ( Böhrer, H; Hofmann, W; Kienle, P; Otto, G; Theilmann, L; Weitz, J, 1997) |
| "A previously healthy but obese 26-yr-old woman was diagnosed as having hepatic dysfunction 17 days after the third of three consecutive exposures to isoflurane anesthesia for paranasal sinus surgery." | 7.68 | Fulminant hepatic failure after repeated exposure to isoflurane anesthesia: a case report. ( Brunt, EM; Holtmann, B; Marsh, JW; Peters, MG; White, H, 1991) |
| "8% enflurane, or 1% halothane in 21% oxygen (air) for two hours resulted in hepatic centrilobular necrosis." | 7.66 | Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Holaday, DA; Kuhnert, L; Phythyon, JM, 1983) |
| "When isoflurane 1." | 5.28 | Effect of isoflurane on the extent of myocardial necrosis and on systemic hemodynamics, regional myocardial blood flow, and regional myocardial metabolism in dogs after coronary artery occlusion. ( Davis, RF; Sidi, A, 1989) |
| "We can conclude that the use of desflurane in these patients provides a pharmacological preconditioning so as to reduce myocardial necrosis and improve the cardiac performance in the postoperative period." | 5.12 | Desflurane preconditioning in coronary artery bypass graft surgery: a double-blinded, randomised and placebo-controlled study. ( Cirri, S; Cosseta, D; Gallazzi, C; Magnani, G; Meco, M, 2007) |
| "A 76-year-old Caucasian woman developed fulminant hepatic necrosis 6 days after an uneventful operation under isoflurane anaesthesia." | 4.80 | Fatal hepatotoxicity after re-exposure to isoflurane: a case report and review of the literature. ( Beringer, TR; O'Rourke, D; Scott, GO; Turner, GB, 2000) |
| "Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups." | 3.85 | Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats. ( Carvalho, LR; Castiglia, YM; Deffune, E; Golim, MA; Lemos, SV; Módolo, NS; Nascimento, PD; Souza, AV; Vianna, IG; Vianna, PT, 2017) |
| "The volatile anesthetic isoflurane protects against renal ischemia and reperfusion injury by releasing renal tubular TGF-β1." | 3.79 | The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury. ( Brown, KM; D'Agati, VD; Ham, A; Kim, JY; Kim, M; Lee, HT, 2013) |
| " We aimed to determine whether isoflurane, the most commonly used volatile anesthetic in the USA, protects against endothelial apoptosis and necrosis and the mechanisms involved in this protection." | 3.78 | Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK. ( Bakar, AM; Kim, M; Lee, HT; Park, SW, 2012) |
| "To evaluate the effect of N-acetylcysteine, as a renoprotective agent, when administered early after anesthesia induction, against ischemia/reperfusion injury in rats anesthetized with isoflurane." | 3.78 | Prevention of renal ischemia/reperfusion injury in rats using acetylcysteine after anesthesia with isoflurane. ( Braz, LG; Castiglia, YM; Fabris, VE; Mansano, AM; Silva, LM; Vianna, PT, 2012) |
| "The purpose of this investigation was to examine the effect of caffeic acid phenethyl ester (CAPE) in renal ischemia/reperfusion injury in rats anesthetized with isoflurane (iso)." | 3.78 | Caffeic acid phenethyl ester effects in the kidney during ischemia and reperfusion in rats anesthetized with isoflurane. ( Carvalho, LR; Castiglia, YM; Correa, RR; de Oliveira, CC; de Souza, AV; Roso, NC; Scatena, LM; Vianna, PT, 2012) |
| " We hypothesized that cells protected by isoflurane against N-methyl-d-aspartate (NMDA)-induced necrosis would instead become apoptotic." | 3.72 | Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. ( Aono, M; Pearlstein, RD; Warner, DS; Wise-Faberowski, L, 2004) |
| "This study determined the induction profiles of immediate-early genes in the ovine brain after cardiopulmonary bypass (CPB) and hypothermic circulatory arrest (HCA), and the effects of the noncompetitive N-methyl-D-aspartate antagonist, aptiganel, on immediate-early gene expression, neuronal necrosis, and functional outcome." | 3.70 | Differential immediate-early gene expression in ovine brain after cardiopulmonary bypass and hypothermic circulatory arrest. ( Bokesch, PM; Kream, RM; Marchand, JE; Seirafi, PA; Trapp, B; Warner, KG, 1998) |
| " We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane." | 3.69 | Fatal hepatic necrosis after isoflurane anaesthesia. ( Böhrer, H; Hofmann, W; Kienle, P; Otto, G; Theilmann, L; Weitz, J, 1997) |
| "A previously healthy but obese 26-yr-old woman was diagnosed as having hepatic dysfunction 17 days after the third of three consecutive exposures to isoflurane anesthesia for paranasal sinus surgery." | 3.68 | Fulminant hepatic failure after repeated exposure to isoflurane anesthesia: a case report. ( Brunt, EM; Holtmann, B; Marsh, JW; Peters, MG; White, H, 1991) |
| "8% enflurane, or 1% halothane in 21% oxygen (air) for two hours resulted in hepatic centrilobular necrosis." | 3.66 | Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Holaday, DA; Kuhnert, L; Phythyon, JM, 1983) |
| "Isoflurane is a volatile anaesthetic that has been commonly used since 1980." | 1.39 | Effects of isoflurane in an intoxication model: experimental study. ( Arici, A; Arici, S; Dogru, S; Karaman, S; Karaman, T; Kaya, Z; Suren, M; Tapar, H, 2013) |
| "A case of fulminant hepatic failure two days following an uneventful operation during isoflurane anesthesia is presented." | 1.38 | Isoflurane hepatitis-induced liver failure: a case report. ( Agrawal, A; Basnyat, PS; Morris, JE; Peiris, LJ, 2012) |
| "Rhabdomyolysis has been reported in dystrophinopathic humans but not in other animal models of dystrophin deficiency." | 1.30 | Lethal peracute rhabdomyolysis associated with stress and general anesthesia in three dystrophin-deficient cats. ( Adé-Damilano, M; Gaschen, F; Gaschen, L; Jaunin, VB; Jmaa, DG; Neiger-Aeschbacher, G; Seiler, G; Welle, M, 1998) |
| "When isoflurane 1." | 1.28 | Effect of isoflurane on the extent of myocardial necrosis and on systemic hemodynamics, regional myocardial blood flow, and regional myocardial metabolism in dogs after coronary artery occlusion. ( Davis, RF; Sidi, A, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.00) | 18.7374 |
| 1990's | 10 (28.57) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 12 (34.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
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| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
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| Meiselbach, H | 1 |
| Nadal, J | 1 |
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| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
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| Eckardt, KU | 1 |
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| Li, H | 4 |
| Yao, L | 2 |
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| Zhu, Z | 1 |
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| Gentile, GL | 1 |
| Rupert, AS | 1 |
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| Yoo, JS | 1 |
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| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
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| Macha, SJ | 1 |
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| Yazdani, V | 1 |
| Irwin, MS | 1 |
| Yang, S | 1 |
| Wheeler, DA | 1 |
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| Hartley, AM | 2 |
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| Xu, JY | 1 |
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| Gilson, E | 1 |
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| Zhang, Y | 6 |
| Hu, Z | 1 |
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| Gestwicki, JE | 1 |
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| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
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| Dong, C | 2 |
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| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
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3 reviews available for isoflurane and Necrosis
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Massive hepatic necrosis and death following repeated isoflurane exposure: case report and review of the literature.
Topics: Adult; Anesthetics, Inhalation; Fatal Outcome; Female; Humans; Isoflurane; Liver; Necrosis | 1996 |
Fatal hepatotoxicity after re-exposure to isoflurane: a case report and review of the literature.
Topics: Aged; Amputation, Surgical; Anesthesia, General; Anesthetics, Inhalation; Chemical and Drug Induced | 2000 |
2 trials available for isoflurane and Necrosis
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Desflurane preconditioning in coronary artery bypass graft surgery: a double-blinded, randomised and placebo-controlled study.
Topics: Anesthetics, Inhalation; Cardiotonic Agents; Coronary Artery Bypass; Coronary Artery Disease; Desflu | 2007 |
31 other studies available for isoflurane and Necrosis
| Article | Year |
|---|---|
Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apoptosis; Cell Survival; Cyclosporine; | 2017 |
The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury.
Topics: 5'-Nucleotidase; Acute Kidney Injury; Adenosine; Anesthetics, Inhalation; Animals; Antibodies, Neutr | 2013 |
Effects of isoflurane in an intoxication model: experimental study.
Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Isoflurane; Kidney; Liver; | 2013 |
Absence of Neuropathology With Prolonged Isoflurane Sedation in Healthy Adult Rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Blood Gas Analysis; Blood Glucose; Conscious Sedation; | 2017 |
Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation.
Topics: Anesthetics, Inhalation; Cells, Cultured; Humans; Isoflurane; Kidney Tubules, Proximal; Lysophosphol | 2010 |
Role of the autonomic nervous system in cardioprotection by remote preconditioning in isoflurane-anaesthetized dogs.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Autonomic Denervation; Autonomic Nervous Syst | 2011 |
Isoflurane activates intestinal sphingosine kinase to protect against bilateral nephrectomy-induced liver and intestine dysfunction.
Topics: Acute Kidney Injury; Alanine Transaminase; Anesthetics, Inhalation; Animals; Apoptosis; Chemical and | 2011 |
Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK.
Topics: Anesthetics, Inhalation; Apoptosis; Cell Line; DNA Fragmentation; Endothelial Cells; Extracellular S | 2012 |
Prevention of renal ischemia/reperfusion injury in rats using acetylcysteine after anesthesia with isoflurane.
Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Creatinine; Isoflurane; Kidney; Kidney Tubules; Ma | 2012 |
Isoflurane hepatitis-induced liver failure: a case report.
Topics: Aged; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Humans | 2012 |
Caffeic acid phenethyl ester effects in the kidney during ischemia and reperfusion in rats anesthetized with isoflurane.
Topics: Anesthetics, Inhalation; Animals; Biomarkers; Caffeic Acids; Creatinine; Disease Models, Animal; Iso | 2012 |
Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Caspase 3; Caspases; Cell Nucleus; Coculture Techniques | 2004 |
Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice.
Topics: Animals; Granulocyte Colony-Stimulating Factor; Inflammation; Interleukin-3; Isoflurane; Kidney; Kid | 2007 |
Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways.
Topics: Anesthetics, Inhalation; Animals; Cell Line; Creatinine; Enzyme Inhibitors; Humans; Isoflurane; Kidn | 2007 |
Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Eating; Enflurane; Halothane; Hyperthy | 1983 |
Hepatic centrilobular necrosis in rats after exposure to halothane, enflurane, or isoflurane.
Topics: Animals; Chemical and Drug Induced Liver Injury; Enflurane; Glutathione; Halothane; Isoflurane; Live | 1982 |
Mild hypothermia during isoflurane anesthesia decreases resistance to E. coli dermal infection in guinea pigs.
Topics: Anesthesia, Inhalation; Animals; Body Temperature; Disease Susceptibility; Escherichia coli Infectio | 1994 |
Hepatic necrosis associated with herpesvirus after anesthesia with desflurane and nitrous oxide.
Topics: Aged; Anesthesia, Inhalation; Anesthetics; Desflurane; Female; Hepatitis; Herpesviridae Infections; | 1994 |
Fatal hepatic necrosis after isoflurane anaesthesia.
Topics: Adult; Anesthetics, Inhalation; Fatal Outcome; Female; Hepatic Encephalopathy; Humans; Isoflurane; L | 1997 |
Lethal peracute rhabdomyolysis associated with stress and general anesthesia in three dystrophin-deficient cats.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Blood Chemical Analysis; Cat Diseases; Cats; | 1998 |
Differential immediate-early gene expression in ovine brain after cardiopulmonary bypass and hypothermic circulatory arrest.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Brain; Cardiopulmonary Bypass; Female; Gene E | 1998 |
Isoflurane reduces N-methyl-D-aspartate toxicity in vivo in the rat cerebral cortex.
Topics: Anesthetics, Inhalation; Animals; Binding, Competitive; Cerebral Cortex; Cerebral Infarction; Dizoci | 1999 |
Isoflurane and pentobarbital reduce AMPA toxicity in vivo in the rat cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Inhalation; Animals; Blood Pr | 2000 |
The influence of hypothermia on hypoglycemia-induced brain damage in the rat.
Topics: Animals; Blood Glucose; Body Temperature; Brain; Brain Diseases; Halothane; Hypoglycemia; Hypothermi | 1992 |
Malignant hyperpyrexia: a rare cause of postoperative death.
Topics: Humans; Isoflurane; Male; Malignant Hyperthermia; Middle Aged; Muscular Diseases; Necrosis; Postoper | 1992 |
Fulminant hepatic failure after repeated exposure to isoflurane anesthesia: a case report.
Topics: Adult; Anesthesia; Chemical and Drug Induced Liver Injury; Female; Humans; Isoflurane; Liver; Liver | 1991 |
Effect of isoflurane on the extent of myocardial necrosis and on systemic hemodynamics, regional myocardial blood flow, and regional myocardial metabolism in dogs after coronary artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Coronary Circulation; Coronary Disease; Dogs; Female; Hemodyna | 1989 |
Hepatic necrosis associated with herpes virus after isoflurane anesthesia.
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Herpesviridae Infections; Humans; I | 1985 |
[Malignant hyperthermia. An unusual course of a rare disease].
Topics: Adult; Ankle Joint; Anterior Compartment Syndrome; Biopsy; Compartment Syndromes; Humans; Isoflurane | 1988 |
A report of hepatic necrosis and death following isoflurane anesthesia.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Isoflurane; Liver; Necrosis | 1987 |
The effect of isoflurane on neuronal necrosis following near-complete forebrain ischemia in the rat.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Electroencephalography; Isoflurane; Male; Methyl Eth | 1986 |