Page last updated: 2024-12-07

1-hydroxyethyl radical

Description

The 1-hydroxyethyl radical, also known as the α-hydroxyethyl radical, is a highly reactive species that plays a significant role in various chemical processes. It is often formed during the oxidation of ethanol or other organic molecules containing hydroxyl groups. The radical is characterized by its unpaired electron located on the carbon atom adjacent to the hydroxyl group. Research studies have explored its generation through different pathways, including photolysis, radiolysis, and reactions with various radicals. Notably, the 1-hydroxyethyl radical is involved in the formation of DNA damage products, specifically 8-oxoguanine, a marker of oxidative stress. Moreover, it contributes to the degradation of polyunsaturated fatty acids, contributing to lipid peroxidation and oxidative damage. The study of this radical is crucial in understanding the mechanisms of oxidative stress and its implications in various diseases, including cancer and neurodegenerative disorders. Its reactivity and propensity to induce damage make it an important subject of research in fields such as biochemistry, toxicology, and environmental science.'

ethoxide : An organic anion that is the conjugate base of ethanol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID119440
CHEBI ID52092
MeSH IDM0179923

Synonyms (14)

Synonym
ethoxide
ethyl alcohol radical
ethoxy anion
CHEBI:52092 ,
hydroxyethyl free radical
ethanol, ion(1-)
1-hydroxyethyl radical
16331-64-9
ethanolate
ethanol, ion(1-) (van)
ethanol at
HHFAWKCIHAUFRX-UHFFFAOYSA-N
DTXSID60167567
Q27123176

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Alcoholic patients and experimental animals exposed to ethanol display biochemical signs of oxidative damage, suggesting a possible role of free radicals in causing some of the toxic effects of alcohol."( Hydroxyethyl radicals in ethanol hepatotoxicity.
Albano, E; French, SW; Ingelman-Sundberg, M, 1999
)
0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
Saccharomyces cerevisiae metaboliteAny fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
organic anionAny organic ion with a net negative charge.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Renz2020 - GEM of Human alveolar macrophage with SARS-CoV-20490

Research

Studies (52)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's18 (34.62)18.2507
2000's23 (44.23)29.6817
2010's9 (17.31)24.3611
2020's2 (3.85)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.36 (24.57)
Research Supply Index4.04 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews5 (8.93%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other51 (91.07%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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