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Neuraminidase
A neuraminidase (Influenza B virus) that is encoded in the genome of strain B/Lee/1940. [PRO:CNA, UniProtKB:P03474]
Synonyms
EC 3.2.1.18
Research
Bioassay Publications (17)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.Journal of medicinal chemistry, , 03-08, Volume: 61, Issue:5, 2018
Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.Bioorganic & medicinal chemistry letters, , Mar-12, Volume: 11, Issue:5, 2001
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.Journal of medicinal chemistry, , Sep-21, Volume: 43, Issue:19, 2000
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.Journal of medicinal chemistry, , Mar-12, Volume: 41, Issue:6, 1998
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.Journal of medicinal chemistry, , Mar-12, Volume: 41, Issue:6, 1998
Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.Journal of medicinal chemistry, , Sep-21, Volume: 43, Issue:19, 2000
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity.Bioorganic & medicinal chemistry, , Jul-15, Volume: 20, Issue:14, 2012
Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.Journal of medicinal chemistry, , Jul-01, Volume: 42, Issue:13, 1999
Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping.Bioorganic & medicinal chemistry letters, , Jul-19, Volume: 9, Issue:14, 1999
Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.Journal of medicinal chemistry, , Jul-01, Volume: 42, Issue:13, 1999
Hydrophobic benzoic acids as inhibitors of influenza neuraminidase.Bioorganic & medicinal chemistry, , Volume: 7, Issue:11, 1999
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.Journal of medicinal chemistry, , Jul-26, Volume: 61, Issue:14, 2018
Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: synthesis and inhibitory activity.Bioorganic & medicinal chemistry letters, , Jun-05, Volume: 10, Issue:11, 2000
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.Journal of medicinal chemistry, , Sep-21, Volume: 43, Issue:19, 2000
Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-05, Volume: 9, Issue:13, 1999
Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity.Bioorganic & medicinal chemistry letters, , Oct-04, Volume: 9, Issue:19, 1999
A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 8, Issue:23, 1998
Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998